What is the difference between ofloxacin and ciprofloxacin? Levofloxacin: analogues, a review of the main drugs similar to Levofloxacin. Respiratory anti-anaerobic quinols: levofloxacin® or moxifloxacin®
Antibiotic substitutes are necessary to prevent allergic reactions to the components, and to exclude serious consequences for the body due to high toxicity.
Many analogs of Levofloxacin, domestic or foreign, have identical active substance, but differ in auxiliary components and pricing policy.
Today we will tell you which ones exist cheap substitutes, their price, country of origin. The cost of the medicine is approximately 140-710 rubles, depending on the form of release and who released it.
What to replace
Before finding a prototype antibiotic, you should consult your doctor. He will determine the required dosage, based on the complexity of the course of the disease, age and weight category.
Some analogs may not be suitable, as they have a weaker effect than Levofloxacin. There is a fairly wide selection of inexpensive drug substitutes on the pharmaceutical market.
Produced in different forms and volumes. On the basis of the active ingredient "levofloxacin", many medicines have been produced in the form of tablets, drops and liquid for injection. Each drug has a specific effect on the desired organ.
In severe cases, doctors often prescribe in the form of solutions for intravenous injection, they are quickly absorbed into the blood and may not cause side effects from the digestive side, as a tablet form.
Before using any drug, you must read the instructions, composition and side effects.
The most common analogues:
Tavanic. The antibacterial agent is available in the form of tablets and injections. The cost varies from 650 - 1650 rubles, depending on the form of the drug. 
"Ciprofloxacin" (Ciprofloxacinum). A cheap antibacterial agent with a wide range actions. Available - drops, solutions, tablets, capsules. The price of an inexpensive medicine ranges from 20 rubles. 
Eleflox. Imported Indian antibiotic. Tablet form for 250-500 mg and solution for infusion 100 ml. The price varies from 357-571 rubles. 
"Ofloxacin" (Ofloxacin). Domestic antibiotic. In some uncomplicated cases, it is an alternative to Levofloxacin. Available: tablets of 200 and 400 mg of active ingredient (price from 32-62 rubles), liquid for intravenous administration of 0.1 l (from 55 rubles). 
Ciprofloxacin
Which one is better to choose is determined by the doctor in each case individually. When choosing a medicine, you need to take into account the severity of the disease, safety, financial capabilities and therapeutic effect.
Many specialists more often give preference to Levofloxacin, it is quite effective, has a pronounced antibacterial effect on pneumococcal infections and gram-positive microbes.
Although some pathogens are resistant to the drug, ciprofloxacin is sometimes preferred. These drugs are rapidly absorbed in the gastrointestinal tract.
Food restrictions - dairy products, help to slow down the absorption of the drug. Easy to use, appoint 1 t. * 2 rubles / day.
Side effects are identical. Differences in cost, so the price of "Ciprofloxacin" varies from 45 rubles, and "Levofloxacin" from 140.
Tavanik
The first belongs to the group of quinolones / fluoroquinolones and is a third generation broad-spectrum antibiotic. It is prescribed for infectious ailments occurring in mild and moderate severity, caused by pathogenic microbes.
It is prescribed for the treatment of acute sinusitis, respiratory organs, pneumonia and infectious processes in the genitourinary sphere. Regenerates skin and soft tissues. The cost is quite high. It is produced not only in tablet form, but also in the form of a solution.
Ofloxacin
The second generation antibiotic belongs to the fluoroquinolone group, which fights against gram-positive and gram-negative bacteria.
Indication of the drug:
- Sinusitis in acute form.
- Pulmonary ailments, bronchitis, pneumonia.
- Diseases of the genitourinary system.
- Inflammation of the prostate gland.
- Skin infections.
- Pathological processes of the gastrointestinal tract.
Both are antibiotics fluoroquinolones, but Levofloxacin is a young third generation antibacterial drug. Therefore, its activity is much higher than Ofloxacin.
But if the pathology proceeds in easy form, for example, primary cystitis, the drug is able to quickly cope with the disease in 3-5 days. But he's got enough side effects, therefore, self-assignment is strictly prohibited.
Active substance
All drugs that are presented in the article today are based on the general - levofloxacin. It is active against a large number of pathogens:
- Enterococcus.
- Diphtheria stick.
- Staphylococcus aureus.
- Streptococcus (agalactia).
- Ureaplasma.
- Chlamydia.
- Pneumococcus.
- Klebsiella.
- Shigella.
- Neisseria.
- Salmonella.
- Proteus.
It is prescribed for pathological processes of the lungs (pneumonia), tuberculosis, anaerobic pathogens. It is successfully used in the treatment of ENT diseases (sinusitis, sinusitis, otitis media), men are prescribed for inflammatory processes in the prostate gland (prostatitis).
V ophthalmic practice in case of eye diseases, the drug based on the active substance is released in vials with a pipette dispenser. Recommended for use in urology and gynecology, for diseases of the urinary system (chronic pyelonephritis, cystitis, urethritis).
Contraindications:
- Individual intolerance.
- Breastfeeding, pregnancy.
- Epileptic seizures.
- Age restrictions: children under 18 and over 65.
Side effects:
- Migraine.
- Dizziness, nausea, vomiting.
- Unstable blood pressure, rhythm disturbance.
- Allergic reactions.
- Decreased vision.
- Insomnia.
Imported
| Name | Who produces | What is produced (tablet form mg) | Cost, rubles |
| "Glevo" | India | 250/500 5, 10, 25 pcs. | 200-900 |
| "Tigeron" | India | 500/750 5 pieces | 540-720 |
| "Haileflox" | India | 500/750 5 pieces | 460-820 |
| "Flexid" | Switzerland | 500 5, 25, 50 pcs. | From 390 |
| "Abiflox" | India | Solution for intravenous injection 100 ml | From 490 |
| Eleflox | India | 500 5, 10 pieces | 410-810 |
Respiratory quinolone generation
The group belongs to the III generation, one of such derivatives is the drug "Sparfloxacin".
The antibiotic is highly effective against gram-negative microbes, has no toxicity, but is not used to treat syphilis either.
Food does not have any effect on the absorption of the drug, therefore it is taken at any time of the day according to the scheme determined by the doctor.
Slightly inferior to its main analogue - Levofloxacin. The course of treatment depends on the severity of the disease and can vary from 1-10 days.
Indications:
- In gynecology: for inflammatory processes in the ovaries.
- Venereal: gonorrhea, chlamydia.
- Diseases of the upper respiratory tract: bronchitis, pneumonia.
- ENT and visual pathologies.
The medicine has a number of contraindications, which are identical to Levofloxacin, only cardiac and renal failure... The cost varies for the tablet form from 340 rubles, depending on the pricing policy of the pharmacy.
Eye drops
Each medicinal product intended for the treatment of ophthalmic problems is produced in vials, where a pipette-dispenser is provided. The cost depends on the country of the manufacturer and ranges from 55 rubles.
Contraindications - during pregnancy and lactation. Side effects - itching and discomfort of the mucous eyes, "veil", deterioration of sharpness, sometimes migraine, swelling. It is not recommended to use contact lenses at the time of therapy.
Analogs:
- Floxal. Indications: conjunctivitis, blepharitis, chlamydia, postoperative period, keratitis. A capacity of 5 ml costs from 175 rubles.
- SIGNICEF. The price of a bottle of 5 ml is from 240.
- Oftaquix. The manufacturer is a French company, the cost varies for 5 ml from 200.
- "Ofloxacin" (Ofloxacin). The price of an antibacterial agent is about 260-270.
- Cipromed. Cost 5 ml from 135.
In tablets
Injection
Manufacturer
Levofloxacin is released worldwide. The first to release the drug in 1987 was a Japanese company. On the territory of the CIS countries, Belarusian and Russian pharmaceutical companies are engaged in the production of drugs.
Ukraine
| Name | Hryvnia price |
| "Abaktal" | 65-325 |
| "Abiflox" | 144-220 |
| "Avelox" | 440-8900 |
| Bigaflon | 294-650 |
| "Gatibakt" | 65-104 |
| Lebel | 173-280 |
| "Levoflox" | 64-195 |
| "Levoflocin" | 26-94 |
| "Lymflox" | 96-552 |
| "Norfloxacin" | 26-27 |
Other substitutes
| Name of the medicine | Description |
| "Sparflo" | Affordable antibiotic, prototype of the original. Available in tablets. Indications: bronchitis, cystitis of all types, urethritis, ophthalmology, venereology, abscess. Price up to 330 rubles. |
| "Tarivid" | An effective antibiotic agent with a bactericidal effect. Available in tablets and solution for intravenous infusion. Indications for therapy are bacterial infections of the lower and upper sections. The cost varies from 490 rubles and more. |
| "Tsiprobay" | Release in the form of liquid for injection and tablets, is considered one of the best analogs levofloxacin. Cost from 320 rubles. |
The cost of analogs
As you can see, the choice of substitutes for Levofloxacin is plentiful in the pharmaceutical market for every pocket and financial ability.
But only the doctor will determine the dosage so as not to harm health, and the result of the therapy will be positive.
Therefore, you do not need to change the antibiotic yourself, it is better to specify initially which inexpensive analogue available at the pharmacy. Subscribe to our site. There is a lot of new information ahead. Be healthy!
According to the instructions for use, the medication is an original wide-profile antibiotic that is active against a number of pathogens of infectious processes in the human body.
Medicinal product Levofloxacin, analogs of which can be presented in different forms ah release, it is effective to use in diseases of the ENT system. Thus, quite often this drug is prescribed to patients with otitis media, sinusitis, sinusitis, pharyngitis, etc. The active ingredient of this drug will be no less effective in relation to skin infectious lesions, as well as diseases of the urinary and reproductive systems (prostatitis, pyelonephritis, chlamydia, etc.).
According to statistics, today Levofloxacin has several medicinal analogues, which can be presented in the form of drops and tablets, as well as have more cheap price... Reviews of these drugs can be read on numerous patient forums. At the same time, more than 60% of adults are regularly exposed to infectious lesions of various body systems, therefore, the need to use Levofloxacin is more than in demand today.
Levofloxacin is produced, analogues of which also have a wide therapeutic spectrum of action, in the form of tablets, solution for injection, as well as eye drops... Concerning pharmacological effect, then this drug is a potent antibiotic that helps to destroy pathogenic infectious foci.
Levofloxacin is contraindicated, like its main substitutes, during pregnancy, childhood, severe kidney and liver diseases. Elderly people need to take such a drug strictly under the supervision of a doctor.
Analogs
All analogues of Levofloxacin (synonyms for therapeutic effect) are divided into two separate subgroups:
- Analogs for the active substance of the drug.
- Pharmacological group analogs.
By active substance
Levofloxacin analogs, which will be presented below, can be prescribed for the treatment of pneumonia, sinusitis, protracted bronchitis, all kinds of urological lesions, as well as pyelonephritis. It is forbidden to prescribe such drugs to children under eighteen years of age, pregnant women, as well as in case of individual intolerance to the active substance of the drug.
The most effective analogues of Levofloxacin (based on the active ingredient) are:
- Amoxiclav.
- Astrafarm.
- Levoten.
- Ciprofloxacin.
- Eleflox.
- Flexid.
- Ofloxacin.
- Tigeron.
Levofloxacin, as well as generics, should be taken in the morning before meals. For acute infectious lesions, the permissible dosage of the drug is 250 mg (1 tablet per day). The duration of therapy is determined by the attending physician. On average, it takes five to ten days to completely suppress the infection.
As for the side effects from analogs of Levofloxacin, compared to the drugs of the previous generation, these drugs are much better tolerated and provoke adverse reactions in no more than 1.5% of all cases. At the same time, patients may experience nausea, abdominal pain, improvement in the functioning of the heart, kidneys and digestive system.
According to the quinolone generation
Sparfloxacin is a striking analogue of Levofloxacin in the generation of quinolones. Also, like Levofloxacin, it belongs to the last, third generation of antibiotics. This drug is most effective against gram-negative foci of infection, in particular, staphylococci.
Sparfloxacin is prescribed for the same patient indications as Levofloxacin (analogs can be prescribed by a doctor). Thus, such an antibiotic can be used to treat chlamydia, leprosy, inflammatory diseases of the urethra and the respiratory system.
As for contraindications, in addition to the standard prohibitions that are attributed to Levofloxacin, Sparfloxacin also has a prohibition in the form of bradycardia and hepatitis.
The price for such an analogue of the drug is 340 rubles per pack (6 tablets).
Tavanic or Levofloxacin: which is better, characteristics and features of the best antibiotic analogues
One of the most popular foreign analogues of Levofloxacin is the drug Tavanik, which is produced by a French manufacturer. Many patients do not know whether Tavanic or Levofloxacin is better.
With a detailed study of both of these drugs, it should be said that, unlike Levofloxacin, Tavanic has only one dosage form release (solution for infusion). This is the disadvantage of this medication.
Tavanic or Levofloxacin (which is better for adults, the attending physician must decide in each case) have very similar indications for use, since both drugs are approved for use in prostatitis, sinusitis, respiratory and genitourinary infections... Moreover, both medicines are available over the counter.
When asked whether Tavanic or Levofloxacin is better, it is also important to note the cost of the first drug, which can reach up to 1200 rubles, which will be significantly higher than the average price for Levofloxacin.
Another analogue of Levofloxacin, which has a similar therapeutic effect, is the drug Moxifloxacin. It has a pronounced antibacterial effect against infectious pathogens of different classes.
Compared to Levofloxacin, Moxifloxacin has the following advantages:
- The drug has a wider spectrum of action.
- Does not provoke allergies when exposed to ultraviolet radiation.
- It can be used in conjunction with other antibiotics without causing negative reactions.
In turn, the following disadvantages of this analogue are distinguished in comparison with Levofloxacin:
- Less effective for urinary tract infections.
- Does not have complete reception security.
- It has a large list of contraindications.
- It has a bad effect on the exchange of vitamins when taken.
As for eye drops, Levofloxacin in this form of release has analogues in the form of Floxal, Signicef and Ofloxacin. It is allowed to use these drugs only as directed by a doctor, with strict adherence to the dosage. If treatment is necessary for children, it is important that the therapy is supervised by a specialist.
In this article we will try to figure out which is better than levofloxacin or ciprofloxacin. To give a thorough answer, you should dwell in more detail on the features of the application of each of these drugs separately.
Ciprofloxacin
Ciprofloxacin belongs to the classical fluoroquinolones, which have broad indications for use in respiratory infections of the lower respiratory tract and ENT pathology. Clinical experience shows that this drug is active against gram-negative bacteria, staphylococci and atypical pathogens (chlamydia, mycoplasma, etc.). At the same time, Ciprofloxacin is not effective enough for diseases caused by pneumococci.
The selection of the optimal drug for the treatment of any disease should be dealt with exclusively by a highly qualified doctor.
Indications
As a broad-spectrum antibacterial drug, Ciprofloxacin is successfully used in the treatment of patients suffering from respiratory infections of the respiratory tract and ENT pathology. For what diseases of the respiratory system and diseases of the ear, throat, nose, this drug from the group of classic fluoroquinolones is used:
- Sharp and Chronical bronchitis(at the stage of exacerbation).
- Pneumonia caused by various pathogenic microorganisms.
- Inflammation of the middle ear paranasal sinuses, throat, etc.
Contraindications
Like most drugs, Ciprofloxacin has its own contraindications. In what situations this representative of classical fluoroquinolones cannot be used in the treatment of diseases of the respiratory tract and ENT pathology:
- Allergic reaction to Ciprofloxacin.
- Pseudomembranous colitis.
- Childhood and adolescence (until the end of the formation of the skeletal system). The exception is children with pulmonary cystic fibrosis who have developed infectious complications.
- Pulmonary anthrax.
In addition, patients with the following disorders and pathological conditions have restrictions on the use of Ciprofloxacin:
- Progressive atherosclerotic lesion blood vessels brain.
- Severe cerebral circulation disorders.
- Various heart diseases (arrhythmia, heart attack, etc.).
- Decreased levels of potassium and / or magnesium in the blood (electrolyte imbalance).
- Depressive state.
- Epileptic seizures.
- Severe violations of the central nervous system(for example, a stroke).
- Myasthenia gravis.
- Serious malfunction of the kidneys and / or liver.
- Advanced age.
Side effects
According to clinical practice, adverse reactions in the prevailing majority of patients taking fluoroquinolones are infrequent. Let's list the undesirable effects that occur in about 1 in 1000 patients taking Ciprofloxacin:
- Dyspeptic disorders (vomiting, painful sensations in the abdomen, diarrhea, etc.)
- Decreased appetite.
- Feeling of heartbeat.
- Headache.
- Dizziness.
- Recurrent sleep problems.
- Changes in the main indicators of blood.
- Weakness, fatigue.
- Allergic reaction.
- Various skin rashes.
- Painful sensations in muscles and joints.
- Functional disorders of the kidneys and liver.
Do not buy Levofloxacin or Ciprofloxacin without first talking to your healthcare professional.
special instructions
With extreme caution, Ciprofloxacin is prescribed to patients who are already taking medications that lead to a prolongation of the QT interval:
- Antiarrhythmic drugs.
- Antibiotics from the macrolide group.
- Tricyclic antidepressants.
- Antipsychotics.
Clinical observations show that Ciprofloxacin enhances the effect of hypoglycemic drugs. With their simultaneous use, careful monitoring of blood glucose should be carried out. It is recorded that drugs that reduce acidity in the gastrointestinal tract (antacids), and which contain aluminum and magnesium, reduce the absorption of fluoroquinolones from the digestive tract. The interval between the use of an antacid and an antibacterial drug should be at least 120 minutes. I would also like to note that milk and dairy products can affect the absorption of Ciprofloxacin.
In case of drug overdose, the development of headache, dizziness, weakness, seizures, dyspeptic disorders, functional disorders from the kidneys and liver. There is no specific antidote. The stomach is washed, activated charcoal is given. If necessary, symptomatic therapy is prescribed. Closely monitor the patient's condition until complete recovery.
Levofloxacin
Levofloxacin belongs to the third generation fluoroquinolones. Possesses high activity against gram-negative bacteria, pneumococci and atypical pathogens of respiratory infections. Most pathogens that show resistance (resistance) to the "classic" second-generation fluoroquinolones may be sensitive to more modern drugs such as Levofloxacin.
Food intake does not affect the absorption of Ciprofloxacin or Levofloxacin. Modern fluoroquinolones can be taken either before or after meals.
Indications
Levofloxacin is a broad-spectrum antibacterial drug. It is actively used for the following diseases of the respiratory system and ENT organs:
- Acute or chronic inflammation of the bronchi (at the stage of exacerbation).
- Inflammation of the paranasal sinuses (sinusitis, sinusitis, etc.).
- Infectious and inflammatory processes in the ear, throat.
- Pneumonia.
- Infectious complications of cystic fibrosis.
Contraindications
Despite the fact that Levofloxacin belongs to the new generation of fluoroquinolones, this drug can not be prescribed in all cases. What are the contraindications to the use of Levofloxacin:
- Allergic reaction to the drug or its analogues from the fluoroquinolone group.
- Serious kidney problems.
- Epileptic seizures.
- Tendon damage associated with previous fluoroquinolone therapy.
- Children and adolescents.
- Periods of childbearing and breastfeeding.
Levofloxacin should be prescribed with extreme caution in elderly patients.
Side effects
As a rule, all adverse reactions are classified according to their severity and frequency of occurrence. Let's list the main undesirable effects from taking Levofloxacin that may occur:
- Functional problems gastrointestinal tract(nausea, vomiting, diarrhea, etc.).
- Headache.
- Dizziness.
- Allergic reactions (skin rash, itching, etc.).
- The level of essential liver enzymes rises.
- Drowsiness.
- Weakness.
- Pain in muscles and joints.
- Tendon damage (inflammation, tears, etc.).
Self-administration of Levofloxacin or Ciprofloxacin without the permission of the attending physician can have serious consequences.
special instructions
Since the likelihood of joint damage is high, Levofloxacin is not prescribed in childhood and adolescence (up to 18 years), with the exception of extremely severe cases. When using antibacterial drugs for the treatment of elderly patients, it should be borne in mind that this category of patients may have impaired renal function, which is a contraindication for prescribing fluoroquinolones.
During therapy with Levofloxacin, patients who have previously suffered a stroke or severe traumatic brain injury may develop epileptic seizures (convulsions). If you suspect the presence of pseudomembranous colitis, you must immediately stop taking Levofloxacin and prescribe the optimal course of therapy. In such situations, it is strongly discouraged to use drugs that inhibit intestinal motility.
Although rare, there may be cases of tendon inflammation (tendonitis) when using Levofloxacin. Older patients are more prone to this kind of adverse reactions. Concomitant use of glucocorticosteroids significantly increases the risk of tendon ruptures. If there is a suspicion of a tendon lesion (inflammation, rupture, etc.), fluoroquinolone therapy is discontinued.
In case of an overdose of this drug, symptomatic therapy should be carried out. The use of dialysis in such cases is ineffective. There is no specific antidote.
During therapy with Levofloxacin, it is not recommended to engage in activities that require increased concentration of attention and quick reactions (for example, driving). In addition, due to the risk of developing photosensitization, refrain from excessive exposure of the skin to ultraviolet rays.
Which drug should you choose?
How to determine which is better than Levofloxacin or Ciprofloxacin? Of course, only an experienced specialist can make the best choice. Nevertheless, when choosing a drug, it is necessary to rely on 3 main aspects:
A good drug is one that is not only effective, but also less toxic and available. In terms of effectiveness, Levofloxacin has its advantages over Ciprofloxacin. Along with the preserved activity against gram-negative pathogenic microorganisms, Levofloxacin has a more pronounced antibacterial effect against pneumococci and atypical pathogens. Nevertheless, it is inferior to Ciprofloxacin in activity against the pathogen Pseudomonas (P.) aeruginosa. It has been noted that pathogens that are resistant to Ciprofloxacin may be sensitive to Levofloxacin.
The type of pathogen and its sensitivity to antibacterial agents are decisive when choosing the optimal fluoroquinolone (in particular, Ciprofloxacin or Lefovloxacin).
Both drugs are well absorbed in the intestine when taken orally. Food practically does not affect the absorption process, with the exception of milk and dairy products. They are convenient to use because they can be prescribed 1-2 times a day. Regardless of whether you take Ciprofloxacin or Levofloxacin, in rare cases, unwanted side reactions may develop. As a rule, dyspeptic disorders (nausea, vomiting, etc.) are noted. Some patients taking second or third generation fluoroquinolones complain of headache, dizziness, weakness, increased fatigue, and sleep disturbance.
In elderly patients, especially with glucorticosteroid therapy, tendon ruptures are possible. Due to the risk of developing joint lesions, fluoroquinolones are limited in use during periods of gestation and breastfeeding, as well as during childhood.
Currently, for most patients, the price aspect is of paramount importance. A package of Ciprofloxacin tablets costs about 40 rubles. Depending on the dosage of the drug (250 or 500 mg), the price may fluctuate, but not significantly. More modern Levofloxacin will cost you an average of 200-300 rubles. The price will depend on the manufacturer.
At the same time, the final decision as to which is best for the patient, Ciprofloxacin or Levofloxacin, is made exclusively by the attending physician.
A selection of the best strong analogues of ofloxacin
Ofloxacin is a second generation fluoroquinolone with a bactericidal effect. The antibiotic is a yellowish crystalline powder that is tasteless and odorless. Mainly gram-microorganisms are sensitive to this drug.
Ofloxacin is active against Escherichia coli, Salmonella, Enterobacter, Serrata Marcescens, Citrobacter, Yersinia, Hemolytic bacillus. Moderately effective against proteus mirabilis, proteus vulgaris, hydrophilic aeromonas, moraxella catarrhalis, propionibacterium acne, clostridia perfringens, Koch's bacillus, etc. The drug is capable of destroying pathogens resistant to sulfonamides.
Ofloxacin inhibits gyrase and affects the process of DNA supercoiling, which leads to destabilization of bacterial deoxyribonucleic acid and cell death. The antibiotic is used in the treatment of diseases of the bacterial etiology of the respiratory tract (pneumonia), ENT organs (otitis media, sinusitis), skin, genitourinary system (urethritis, pyelonephritis).
Ofloxacin is one of the most popular drugs in ophthalmic practice. The drug was patented in the early 80s of the last century. The Russian-made antibiotic has a democratic price: it costs no more than 60 rubles.
Ofloxacin analogues by active substance
Vero-Ofloxacin is available in the form of tablets (10 pieces per package), each of which contains 200 mg of the active active ingredient. The drug disrupts DNA replication in the pathogen cell. The drug is widely used in urology, nephrology, rheumatology and dermatology.
Vero-Ofloxacin is contraindicated in patients with tendon lesions, children under 18 years of age, as well as patients with diseases of the central nervous system, accompanied by epileptic seizures. The drug is not prescribed for pregnant women during the period of antibiotic therapy breast-feeding stop. Vero-Ofloxacin causes complications from the sensory organs and the nervous system, the musculoskeletal system, the digestive tract, urinary tract and hematopoietic organs.
Vero-Ciprofloxacin belongs to the group of fluoroquinolones, acts on the pathogenic flora bactericidal. The main active ingredient is ciprofloxacin. The antibiotic stops the synthesis of bacterial cellular proteins.
Resistant to drugs are corynebacteria, bacteroids fragilis, stenotrofomonas maltophilia, ureaplasma urealiticum, clostridium dificile. The drug is rapidly absorbed from the gastrointestinal tract. Vero-Ciprofloxacin is able to penetrate into the cerebrospinal fluid. The dosage depends on the severity of the infectious process, the patient's body weight, age (not prescribed until eighteen years old), the presence of liver and kidney dysfunctions.
Zanocin belongs to the second generation fluoroquinolones. Inhibits the enzyme DNA gyrase, which is involved in the biosynthesis of bacterial DNA. Zanocin is active against aerobes and anaerobes, it is not affected by beta-lactamases. The antibiotic causes the eradication of Mycobacterium, Chlamydia trachomatis and Mycoplasma. Viruses, fungi, protozoa and treponema are resistant to Zinocin.
Food intake does not affect digestibility. The maximum concentration is reached on average after a couple of hours. The drug is able to penetrate into cells. An antibiotic is prescribed for sinusitis, otitis media, pneumonia, legionellosis, typhoid fever, shigellosis, tuberculosis, gonorrhea.
Zanocin OD is a long-acting antimicrobial agent (release medicinal substance occurs gradually), which can be taken once a day. Zanocin OD is active against gram + and gram aerobes and anaerobes. Bioavailability exceeds 90%.
The pharmacological agent is able to penetrate the blood-encephalic and uteroplacental barriers. The half-life is about 7 hours. In patients with liver pathologies, the rate of antibiotic elimination is reduced. The dosage for such patients is selected according to the degree of decrease in creatinine clearance. The drug is used with caution to treat elderly patients. Most often, side effects occur from the gastrointestinal tract, hepatobiliary system, and the musculoskeletal system. Also possible allergic reactions, changes in indicators of peripheral blood, toxic effect on the kidneys.
Ofloxacin TEVA is manufactured in Hungary. The antibiotic affects the speed of psychomotor reactions and concentration. Drugs are prescribed for diseases of the lower respiratory tract, ENT organs, skin and pelvic organs.
The drug is not prescribed until the age of 18, during lactation, with craniocerebral injuries, pathologies of the central nervous system, hypolactasia, polyradiculoneuropathy. Ofloxacin TEVA has an extensive list of side effects: antibiotic therapy with this drug can provoke increased gassing, dry mouth, sleep disturbances, involuntary tremors of the limbs, convulsions, intracranial hypertension, color blindness, demotion blood pressure, bullous dermatitis, tendon rupture, photosensitivity, etc.
Ofloxacin-ICN is an antimicrobial agent related to fluoroquinolones. Affects the stability of bacterial DNA. Ofloxacin-ICN is active against pathogens that produce β-lactamases, as well as mycobacteria.
Doctors prescribe an antibiotic for pneumonia, pyelonephritis, urethritis, chlamydia, and systemic inflammatory reactions. Ofloxacin-ICN is widely used in gynecological practice (inflammation of the vaginal mucosa, inner lining of the uterus, fallopian tubes, ovaries, vaginal segment of the cervix). Not used in the treatment of tonsillitis.
Ofloxacin-AKOS is taken no more than ten days. The course of treatment depends on the sensitivity of the strains and on clinical picture diseases. Reception is carried out before meals or after.
Therapy with this antibiotic may be accompanied by dyspeptic disorders, an increase in the concentration of bilirubin in the blood serum, pseudomembranous enterocolitis, vertigo, insomnia, anxiety, tenosynovitis, maculopapular rash, a sharp decrease in the number of erythrocytes, platelets and leukocytes, neutrophils. In sick diabetes mellitus there is a decrease in the concentration of glucose in the blood.
Ofloxacin-Promed is a broad-spectrum antibiotic that is highly active against most gram-negative microorganisms. Food intake slows down the absorption rate slightly.
Plasma protein binding is 25 percent. In elderly patients, the half-life can be up to hours. The antibiotic is widely used in many branches of medicine: from otolaryngology and pulmonology to gynecology and urology. The dosage is selected individually. During antibiotic therapy, the patient should not be exposed to ultraviolet rays.
Ofloxacin-FPO is a domestic drug that destroys infectious agents by destabilizing DNA strands. Ofloxacin-FPO is characterized by a large volume of distribution, therefore, almost the entire amount of the administered drug is capable of penetrating into the cells. Preparations containing aluminum, calcium and magnesium significantly reduce the absorption of the active ingredient.
Not the drug of choice for pneumococcal pneumonia. In elderly patients, there is a risk of rupture of the heel tendon when taking drugs. In case of side effects, treatment is stopped immediately.
Tarivid is an antimicrobial drug belonging to the II generation of fluoroquinolones. The antibiotic is completely absorbed in the gastrointestinal tract. Peak serum concentrations are reached in about an hour. The bioavailability of the drug reaches one hundred percent. Tarivid is excreted from the body almost unchanged.
There is no significant difference between ingestion and injections. The antimicrobial drug is indicated for inflammation of the bronchi, infections of the skin and subcutaneous fat, pelvic organs. Tarivid is prescribed as a prophylaxis for patients with weakened immune systems.
Concentrations that help kill bacteria are maintained by taking the antibiotic at regular intervals. Medicines intended for the treatment of gastrointestinal diseases through neutralization of hydrochloric acid must be taken separately from Tarivid.
Analogs used in ophthalmological and otological practice
Dancil is an Indian drug that destabilizes DNA strands, which leads to the elimination of bacteria. Dancil is resistant to the effects of many enzymes: β-lactamases, phosphorylases and adenylases. Active against strains sensitive to ofloxacin.
Dancil is prescribed for the treatment of ulcerative keratitis, blepharitis, conjunctivitis, keratoconjunctivitis and meibomitis. The course of treatment should not exceed five days. Instillation into the auricle is recommended to be carried out with a warm solution (the bottle is warmed in the palms of the hands). The antibiotic is not prescribed for children under eighteen years of age.
The drug is used as a prophylaxis for infections during ophthalmic operations.
Uniflox has a pronounced bactericidal effect. The drug inhibits the activity of the second kind topoisomerase. Strains resistant to antibiotics of the penicillin and methicillin series are sensitive to Uniflox.
The drug is active against a number of bacteria that do not have a cell wall. Peptococci, bacteroids and clostridia are not affected by this antimicrobial drug. The active ingredient penetrates well into the corneal tissue. The concentration that provides a therapeutic effect is maintained for four hours.
Reception of Uniflox is part of preventive measures after surgical interventions on the organs of vision.
Floxal is an almost transparent light yellow solution. The bactericidal effect is achieved by blocking DNA gyrase. The drug is highly active against gram and gram + microbial flora. Floxal is capable of destroying pathogenic microorganisms that are resistant to β-lactam antibiotics.
The activity of aerobic microorganisms is not reduced in the presence of of this drug... Drops are indicated for chronic inflammation of the eyelids, hair follicles of the eyelashes, conjunctiva, cornea of the eye and for blockage of the nasolacrimal canal. During antibiotic therapy, contact lenses should be avoided.
After installations in the conjunctival sac, the development of increased sensitivity of the eye to light is possible.
Floxal ointment is manufactured in the United States of America. The antibiotic is intended for topical application in ophthalmology, refers to fluoroquinolones. The destruction of the facultative flora occurs due to the blockade of topoisomerase, which is involved in the synthesis of the daughter molecule of deoxyribonucleic acid on the template of the parent DNA molecule. Bacteroides urealyticus is the only anaerobe sensitive to the effects of Floxal.
The ointment is contraindicated for lactating and pregnant women. There are no data on the negative effect of the antibiotic drug on the fetus. The ointment reduces visual acuity, which should be taken into account when driving a vehicle.
Norfloxacin vs Ofloxacin: which is better?
Norfloxacin works for twelve hours. The antibiotic is available in the form of film-coated tablets of a bluish hue.
Norfloxacin is active against Staphylococcus aureus, gonococcus, meningococcus, Escherichia coli, Klebsiella, Salmonella, Vibrio cholerae, Pfeiffer's bacillus, Chlamydia and Legionella.
Norfloxacin is used in the treatment of infectious lesions of the genitourinary system, uncomplicated gonorrhea, salmonellosis, shigellosis and as a prophylaxis for diarrhea in people traveling to other, unfamiliar countries or climatic zones. The antibiotic is contraindicated in cases of impaired liver and kidney function, diseases of the nervous system, persons under eighteen years of age, pregnant and lactating women. An antibiotic should not be combined with medicines that lower blood pressure.
Drugs are taken orally one hour before or two hours after the last meal. The tablet is taken with a sufficient amount of liquid. The dosage depends on the localization of the infectious process. Patients connected to the artificial kidney machine take only half of the therapeutic dose. Use with caution in cerebrovascular atherosclerosis.
Side effects include stool disturbances, a bitter taste in the mouth, dysbiosis, abdominal pain, thrush, lethargy, changes in the blood picture, painful palpitations, hypotension, arteritis, erythema malignancy, nephritis, dysuric disorders, proteinuria and crystalluria.
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Levofloxacin: Analogs, Review of Essential Medicines Similar to Levofloxacin
According to the latest medical statistics, the spread of prostatitis and its forms has recently begun to increase. The reasons for this situation can be called a lot of factors, among which, the main place is occupied by a man's unsatisfactory attitude to his health, poor ecology, poor-quality food, etc.
Therefore, it is not surprising how seriously pharmacologists have to work in order to offer patients the newest and most effective drugs for the treatment of prostatitis. Among them, there is also Levofloxacin - an antibiotic last generation, with a wide range of actions.
This type of drug, like Amoxiclav, belongs to antibiotics with a wide spectrum of action and is ideal for systemic treatment various diseases, including prostatitis (acute, chronic, bacterial).
The release form of the drug is tablets or injection solutions. Any form of the drug is quickly absorbed into the bloodstream, affects the body at the cellular level, and the targeted action of the drug allows you to effectively kill entire colonies of harmful microorganisms. For people suffering from infectious and bacterial diseases, it will be much cheaper to purchase such a medication than to buy other synonyms and antibiotic substitutes, which also have side effects and contraindications.
Levofloxacin analogs have the following properties:
- They have a wide and active range of effects on the body.
- They are able to quickly penetrate the tissues of the prostate.
- They show a high degree of activity and directed action.
Before taking the medicine, you should read all the information that the instructions for taking the medicine offer you. Like any other antibiotic, domestic or imported, Levofloxacin can cause side effects and individual intolerance.
Today you can choose not only Levofloxacin, analogues of this drug, similar in composition, action and form of release, are presented on the market in large quantities.
Tavanic is the same effective antibiotic that is prescribed for a variety of diseases. Characterized high degree drug activity and impact on groups of harmful microorganisms, its use allows you to obtain positive treatment results in the shortest possible time of therapy. The price of the product depends on the form of release: tablets can be bought from 600 rubles, solution for injections, it will cost you 1620 rubles.
Ciprofloxacin is an active antibiotic with a broad spectrum of action. It is used to treat infectious diseases internal organs and tissues, in particular - the genitourinary system. The drug is produced in different forms, for example, this and eye drops, suspensions and solutions for injection, tablets and capsules. The cost of the antibiotic is low, from 18 rubles, and any pharmacy can offer you this drug.
Along with the above Russian counterparts, there are also foreign analogues of Levofloxacin on the market that can defeat any infectious disease.
Eleflox, produced by Indian pharmaceutical company, is actively used to treat various forms of prostatitis, inhibits the activity of harmful microorganisms. It is used in systemic treatment, in which the disease quickly responds to therapy.
Glevo is a product of Indian pharmacology, with a wide spectrum of action, excellent for the treatment of all forms of prostatitis.
Levofloxacin belongs to the group of fluoroquinols. The same group with the active substance levofloxacin includes:
All antibiotics in this group are very effective in the treatment of prostatitis. Therefore, your choice of a drug can only be influenced by the presence of an individual intolerance to the components of one of them, the severity of the disease, at which it is necessary to apply complex treatment, in which not all antibiotics may be compatible with other drugs. All drugs have detailed instructions, after reading which, you will find out what side effect can be expected, what contraindication in your case may affect the choice of the remedy.
Tavanic or Levofloxacin which is better?
As we have already noted, both of these drugs belong to the group of fluoroquinols, with an active ingredient - levofloxacin, which quickly enters the bloodstream, then it is taken by the plasma and distributed to all tissues of the body.
The drug Levofloxacin has an active effect on various affected harmful microorganisms areas of tissue, and it acts directly at the cellular level, which speeds up treatment and gives positive results. With prostatitis, different groups of bacteria can be present in the body that affect the organ and disease causing: anaerobic gram-positive and gram-negative, simple microorganisms and chlamydia. With all these "pests" the drug fights very effectively.
Tavanic is a latest generation antibiotic with high rates effectiveness in the treatment of diseases of various internal organs, bone tissue.
The active substance in the drug is levofloxacin, auxiliary - crospovidone, cellulose, titanium dioxide, macrogol 8000, iron oxide red and yellow. When taking the drug, its concentration in the blood lasts for a rather long period.
An antibacterial drug gives the fastest and most positive results in the treatment of various forms of prostatitis, ranging from mild to chronic, as it affects tissue cells, their membranes and walls. Especially effective for complex treatment since its current and active ingredient- levofloxacin, interacts well with other drugs.
If we compare Tavanic or Levofloxacin, which is better, then the first drug has fewer side effects and has more quick action and the spectrum of its impact is much wider.
Comparing the cost of drugs, it can be noted that you can buy Levofloxacin at a price of 77 rubles, and Tavanik - from 590 rubles.
Most often, when the doctor prescribed a course of treatment with this drug, the patient is prescribed 2 doses.
The average daily dose of the drug at each dose ranges from 500 ml to 1 g., Depending on what form of the disease is prostate... If injections are prescribed, then the daily dose of liquid is from 250 to 500 ml, depending on the severity of the disease. The medicine is taken regardless of food intake. the mucous membrane quickly absorbs the substances of the drug.
In milder forms of prostatitis, as well as in diseases that affect the bronchi, the course of treatment can be from 14 to 28 days. In this case, the daily dose ranges from 500 ml to 1 g.
To decide whether Tavanic or Levofloxacin is better, your doctor will help you, who will select the optimal antimicrobial drug for effective therapy.
Levofloxacin or Ciprofloxacin: Comparative Evaluation of Drugs
The medicine has a wide spectrum of action, inhibits the vital activity of various microorganisms, quickly enters the bloodstream, is distributed throughout the tissues of the body, and any infection is amenable to such therapy.
The doctor prescribes the drug, who calculates daily dose medicines.
The course of treatment can be from 1 to 4 weeks, depending on the degree of the disease.
If we consider Levofloxacin and Ciprofloxacin, the difference is that the former is more effective, it can interact with other drugs, while Ciprofloxacin under the influence of other drugs can reduce its concentration and activity, which delays the course of treatment.
Both drugs, Levofloxacin and Ciprofloxacin, are antibiotics that should only be taken on the advice of a physician who considers each case individually.
The main difference between the two antibiotics is the active substance: in the first drug it is levofloxacin, and in the second it is ofloxacin. Under the action of Ofloxacin, not all groups of bacteria can be destroyed, since microorganisms have different degrees of sensitivity to ofloxacin, therefore, prostatitis therapy may be different due to the causes of the disease and the effectiveness of treatment may also differ.
Levofloxacin Astrafarm: description of the drug and its distinctive features
Distinctive features from Levofloxacin
Levofloxacin Astrapharm is able to inhibit the activity of gram-positive and gram-negative microbes, while Levofloxacin acts on all groups of bacteria.
Most often, Levofloxacin Astrapharm is used for effective treatment bacterial chronic prostatitis.
During therapy with Levofloxacin, positive dynamics is observed already in the middle of treatment, and this happens regardless of the form of the disease.
If we talk about Levofloxacin Astrafarm blister, then it is more effective in the treatment of mild and moderate forms of prostatitis.
Regardless of what choice you make in the treatment of prostatitis, you must remember that only systemic, well-chosen treatment can give positive dynamics and results.
Specialty: Urologist Work experience: 21 years
Specialty: Urologist-andrologist Work experience: 26 years
The group of fluoroquinolones, to which the antibiotic Ciprofloxacin belongs, appeared relatively recently. The first drug of this type began to be used only in the 1980s. Previously, antibacterial agents of this class were prescribed only for urinary tract infections. But now, due to their broad antimicrobial activity, fluoroquinolones, including the antibiotic Ciprofloxacin, are prescribed for bacterial pathologies that are difficult to treat, or with an undetected pathogen.
The mechanism of the bactericidal action of this drug is based on the penetration of the pathogenic microorganism through the cell membrane and the effect on the reproduction processes.
Fluoroquinolones inhibit the synthesis of bacterial enzymes that determine the twisting of the DNA strand around nuclear RNA; these are type I topoisomerase in gram-negative bacteria and class IV topoisomerase in gram-positive bacteria.
The antibiotic Ciprofloxacin is active against a wide range of bacteria resistant to the action of most antimicrobial drugs (Amoxicillin and its more effective analogue Amoxiclav, Doxycycline, Tetracycline, Cefpodoxime and others).
As indicated in the instructions for use, such bacterial strains are sensitive to the action of Ciprofloxacin:
- golden and saprophytic staphylococcus;
- the causative agent of anthrax;
- streptococcus;
- legionella;
- meningococcus;
- yersinia;
- gonococcus;
- haemophilus influenzae;
- moraxella.
Escherichia coli, enterococci, pneumococci and some strains of proteus are moderately sensitive. Resistant to the antibiotic Ciprofloxacin of mycoplasma and ureaplasma, listeria and other, infrequently found bacteria.
The drug belongs to the second generation fluoroquinolones, while its analogue of the same group, the no less common Levofloxacin, belongs to the third generation and is more used for the treatment of diseases of the respiratory tract.
The advantage of the antibiotic Ciprofloxacin is a wide range of dosage forms. So, for treatment bacterial infections eye to reduce the risk of systemic side effects, the medicine is prescribed in the form of eye drops. In severe diseases, injections of Ciprofloxacin are needed, or rather, infusions, the standard dosage is 100 mg - 200 mg / 100 ml. After the patient's condition is normalized, the patient is transferred to tablets (they are available with an active ingredient concentration of 250 and 500 mg). Accordingly, the price of the drug is also different.
The main ingredient of the drug is ciprofloxacin, the presence of excipients depends on the specific form of antibiotic release. In a solution for infusion, it is purified water and sodium chloride, in eye drops - various solvents and stabilizers, in tablets - talc, silicon dioxide, cellulose.
The antibiotic Ciprofloxacin is prescribed to children from 5 years of age and adults to treat the following diseases:
- lesions of the lower respiratory tract, including pneumonia caused by flora sensitive to fluoroquinolones;
- ENT infections - organs, including sore throat, otitis media, sinusitis;
- diseases of the genitourinary system, for example, cystitis, pyelonephritis, urethritis, gonorrhea, bacterial prostatitis, adnexitis;
- varied intestinal infections(shigellosis, salmonellosis, typhoid fever, cholera, enteritis, colitis);
- sepsis, peritonitis;
- infections affecting the skin, soft tissues, bones and cartilage, bacterial complications after burns;
- anthrax;
- brucellosis;
- yersiniosis;
- borreliosis;
- tuberculosis (as part of complex therapy);
- specific prophylaxis of bacterial infections in immunocompromised patients with HIV or AIDS, or the use of cytostatics.
In the form of eye drops, the antibiotic Ciprofloxacin is prescribed for infections of the mucous membrane of the organs of vision. According to experts, no cases of the development of resistance of the bacterial flora to the action of the drug have been identified to date. But fluoroquinolones are considered unsafe drugs, so they are not considered first line drugs for the treatment of uncomplicated bacterial infections.
Ciprofloxacin intramuscularly and in the form of eye drops and tablets
When taken orally, the antibiotic is absorbed quickly enough, mainly these processes occur in the lower parts of the digestive tract. The maximum concentration is reached in an hour and a half after using the Ciprofloxacin tablet. The general bioavailability of the drug is high and is about 80% (the exact indicators of the concentration of the active ingredient in the body depend on the dose taken).
Only dairy products affect the absorption of the antibiotic, therefore, they are advised to be excluded from the diet during treatment. Otherwise, food intake slows down the assimilation of Ciprofloxacin, but the bioavailability indicators do not change.
The active component of the drug binds to plasma proteins only by 15-20%. Basically, the antibiotic is concentrated in the pelvic organs and abdominal cavity, saliva, lymphoid tissue of the nasopharynx, lungs. Ciprofloxacin is also found in synovial fluid, bone and cartilage tissue.
The drug enters the spinal canal in small quantities, therefore, it is practically not prescribed for lesions of the central nervous system. Approximately one third of the total dosage of Ciprofloxacin is metabolized in the liver, the rest is excreted by the kidneys in an unchanged form. The half-life is 3-4 hours.
The exact amount of medication prescribed, as well as the duration of treatment, depends on many factors. First of all, this is the patient's condition. The standard recommendation for using any antibacterial agent is to continue taking it for at least three days after the temperature has returned to normal. This applies to both oral forms and the use of Ciprofloxacin intramuscularly.
For adults, the dosage of the drug is 500 mg twice a day, regardless of food intake.
The annotation to the drug indicates the average duration of therapy:
- for diseases of the respiratory tract - up to two weeks;
- with lesions of the digestive system from 2 to 7 days, depending on the severity of the clinical picture and the causative agent of the infection;
- in diseases of the genitourinary system, prostatitis therapy lasts the longest - up to 28 days, to eliminate gonorrhea, a sufficient single dose, with cystitis and pyelonephritis, treatment continues for up to 14 days;
- with infections of the skin and soft tissues - an average of two weeks;
- with bacterial lesions of bones and joints, the duration of therapy is determined by the doctor and can last up to 3 months.
Important
A severe course of infection is an indication for increasing the daily dosage for an adult to 1.5 g.
Important
The maximum daily dosage of the drug in childhood should not exceed 1.5 g per day.
Ciprofloxacin is not administered intramuscularly. The antibiotic solution is administered intravenously only. Moreover, its action develops much faster than that of tablets. The maximum concentration in blood plasma is reached after 30 minutes. The bioavailability of Ciprofloxacin solution is also higher. With intravenous injections, it is almost completely excreted unchanged by the kidneys within 3-5 hours.
Unlike tablets, for many uncomplicated bacterial diseases, a single infusion of Ciprofloxacin is sufficient. In this case, the daily dosage for adults is 200 mg or two injections during the day. For a child, the required amount of the drug is determined by the proportion of 7.5-10 mg / kg per day (but not more than 800 mg per day).
The ready-made solution for infusion is not produced in small ampoules, but in 100 ml vials, the concentration of the active substance is 100 or 200 mg. The drug can be used immediately, it does not require further dilution.
Eye drops with ciprofloxacin are intended for the treatment of various infectious eye lesions (conjunctivitis, blepharitis, keratosis and ulcers) caused by sensitive flora. Also, the drug is prescribed to prevent postoperative and post-traumatic complications.
The total volume of the bottle with drops is 5 ml, while 1 ml of the solution contains 3 mg of active ciprofloxacin. With moderately severe symptoms of the disease and in preventive purposes the drug is prescribed 1-2 drops in each eye every four hours. For complicated infections, the frequency of use is increased - the procedure is repeated every two hours.
Ofloxacin or Ciprofloxacin: which is better, other analogues of the drug, restrictions on use
The use of the drug is categorically contraindicated during pregnancy and lactation. In addition, Ciprofloxacin affects the formation of the structure of bone and cartilage tissue, therefore, it is prescribed for children under 18 only for strict medical reasons.
Also, a contraindication to taking the drug is an increased sensitivity not only to Ciprofloxacin, but also to other drugs from the group of fluoroquinolones.
Antibiotic use should be carried out under strict medical supervision in case of impaired renal excretory function, severe diseases of the central nervous system. If the use of Ciprofloxacin is started after surgery under general anesthesia, monitor the indicators of pulse and blood pressure.
Unlike other, safer antibacterial drugs from the class, for example, penicillins, the risk of adverse reactions during therapy with Ciprofloxacin is high.
The patient is warned of the following possible side effects:
- impaired clarity of vision and color perception;
- the occurrence of a secondary fungal infection;
- digestive disorders, accompanied by vomiting, nausea, heartburn, diarrhea, inflammatory lesions of the intestinal mucosa rarely develop;
- dizziness, headache, sleep disorders, anxiety and other disorders of the psychoemotional state, sometimes - convulsions;
- hearing impairment;
- acceleration of heart rate, arrhythmias against the background of low blood pressure;
- shortness of breath, impaired lung function;
- disorders of the hematopoietic system;
- deterioration in kidney and liver function;
- rashes, itching, swelling.
Ciprofloxacin is found in many drugs.
So, instead of this medicine, the doctor can prescribe the following medicines to the patient:
- Tsiprolet (solution for infusion, eye drops, tablets of 250 and 500 mg);
- Betacyprol (eye drops);
- Quintor (tablets and infusion solution);
- Tsiprinol (in addition to solution for injection and conventional tablets, there are also capsules with prolonged action);
- Cyprodox (tablets with a dosage of 250, 500 and 750 mg).
If we talk about analogues of this antibiotic, we should also mention other antibacterial agents from the group of fluoroquinolones. So, patients often ask a doctor, Ofloxacin or Ciprofloxacin, which is better? Or maybe replace with more modern Norfloxacin or Moxifloxacin?
The fact is that the indications for use for all of the listed funds are the same. Like Ciprofloxacin, they work well against the main pathogens of cystitis, pneumonia, prostatitis and other infections. But doctors emphasize that the "older" the generation of fluoroquinolone, the greater its activity against pathogenic flora. But at the same time, the risk of severe adverse reactions also increases.
Therefore, the question of Ofloxacin or Ciprofloxacin, which is better, is not entirely correct. An antibiotic should be prescribed solely on the basis of the identified pathogen and general condition the patient. In other words, if the doctor sees that Ciprofloxacin will completely cope with, for example, pyelonephritis, then there is no need to prescribe the stronger, but less safe Norfloxacin or Lomefloxacin.
As for the cost of an antibiotic, it largely depends on the manufacturer and the purity of the substance used for the production of the drug. So, domestic eye drops with Ciprofloxacin cost from 20 to 30 rubles. A pack of 10 tablets with a dosage of 500 mg will cost 120-150 rubles. The cost of one bottle of solution for infusion ranges from 25-35 rubles.
Natalia, 50 years old
“Ciprofloxacin has been prescribed to treat kidney inflammation. Before that, other, weaker antibiotics were prescribed, but only this drug helped. The first few days I had to endure droppers, then transferred to pills. Also pleased low price medicines. "
Given the high risk of dangerous adverse reactions, only a doctor should decide whether Levofloxacin or Ciprofloxacin is better. The drugs are quite toxic, therefore it is additionally recommended to take biochemical and clinical blood and urine tests to prevent possible complications therapy.
Modern antibiotics for the treatment of cystitis, such as Ofloxacin and Levofloxacin, are considered universal drugs that can suppress the activity of most bacteria.
Their appointment does not require a preliminary laboratory study of pathogens and determination of their sensitivity to these drugs, which makes it possible to start treatment in a timely manner.
Ofloxacin - description of the drug
Ofloxacin - synthetic antibacterial drug, obtained as a result of the improvement of nalidixic acid, belongs to the class of fluoroquinolones, named similarly to the main active ingredient. The use of Ofloxacin for cystitis is due to the fact that it:
- It is directed to the organs of the small pelvis - the target of treatment, while it does not settle in the liver;
- It has low level microbial resistance;
- Has a wide spectrum of action against gram-negative and gram-positive bacteria, some types of protozoa;
- Due to the possibility of simultaneous reception with others, it is widely used as part of complex therapy for diseases of the urinary tract;
- It is widely used in the period of pre-medical care as a catalyst for the development of protective blocks in the body.
Important! Ofloxacin practically does not affect lacto- and bifidobacteria, as a result of which it occupies one of the leading positions in the sparing treatment of bacterial infectious diseases of the urinary tract.
In case of an uncomplicated course of the disease, the drug is prescribed in a short course (from 3 to 5 days), in case chronic form cystitis treatment is extended up to 10 days.
The dosage is selected individually and on average ranges from 200 to 800 mg of the drug per day, calculated for several doses. A single dose, if necessary, can be 400 mg.
2 hours after administration, the drug is maximally concentrated in the blood, producing a therapeutic effect, and is excreted from the body within 24 hours. Young age (up to 18 years), pregnancy and lactation are contraindications for taking Ofloxacin.
Levofloxacin - description of the drug
Levofloxacin (Levofloxacin) - a drug designed to combat atypical bacteria, obtained as a result of serious pharmacological developments, the isomer of ofloxacin is an effective drug of the latest generation of fluoroquinolones, ideal for systemic treatment.
The main active ingredient is levofloxacin hemihydrate, which:
- Blocks the formation of DNA of pathogenic bacteria, inhibits their reproduction;
- Prevents the penetration of pathogens into the mucous membrane Bladder;
- Quickly relieves acute inflammation;
- Resistance develops slowly and does not interfere with other antibiotics.
The drug is bioavailable, quickly and completely absorbed by the body, due to which it penetrates well into organs, tissues and mucous membranes.
Take up to 2 times a day, swallowing the tablets completely and drinking plenty of water. The dosage is determined by the severity of the disease and ranges from 250mg to 500mg over 3-14 days.
Important! Clinical researches the effects of the drug on women during pregnancy and lactation, as well as children, are not sufficient, therefore, its use should be determined by the degree of risk for this group of patients.
Levofloxacin or Ofloxacin. What is more effective for cystitis?
Both drugs belong to an important group of fluoroquinolones and are actively used in the therapeutic practice of treating cystitis. In the presence of identical mechanisms of action on atypical pathogens, Levofloxacin belongs to the III (new) generation antibiotics, which are characterized by a higher clinical activity and a minimal set of side effects.
When the drug is absorbed internally, Levofloxacin with cystitis behaves in relation to pathogenic microbes 2 times more active than Ofloxacin, which is an important advantage in choosing a treatment.
In case of ineffectiveness of the therapeutic course with one of the drugs, the doctor diagnoses a complicated bladder infection and sends the patient for a urological examination to identify possible pathologies and prescribes a new treatment adequate to the patient's condition.
