At the dawn of the history of mankind, epidemics were considered infectious diseases. With the advent of vaccines and antibiotics of acuity and the social significance of this problem tremendously decreased. The metabolic diseases are now on the fore. The most common are sugar diabetes, obesity. Often they are encountered together. To all these diseases in some cases, a gout is added. Painful exacerbations, inflammation of the joints - a reason for prescribing drugs. Modern medicine offers a wide range of means for treating gout.

Causes and manifestations of gout

Gout - a specific metabolic disease, gradually leading to a significant damage to the kidneys and joints. Pathology is quite common. Among the sick are more common men. Women suffer from gout much less often. The cause of the disease is disturbed uric acid exchange in the body. In the norm of the kidney strictly regulate the content of this substance in the blood. An excess of uric acid precursors in food leads to its deposition in various parts of the body. For surals among patients with gout predominate men with overweight, consulating alcohol and meat products. Located in blood in suspension. The excess amount is deposited in the joints, skin, kidneys and urinary trait. In the first two cases, the accumulation of uric acid is called tofuces. Inside the pellets of kidneys and ureterals, urinary acid falls into a precipitate and forms concrections.

Gout strikes joint

The presence of uric acid in organs and tissues inevitably causes inflammation. Usually the gout flows according to the script chronic disease With a series of exacerbation and subsidiaries of symptoms. The first in the process are involved in the minor joints of the stop and brushes. Uric acid is deposited inside the skin, large joints, kidneys. Tufasi contain inside a white powder mass. Accumulating between the surfaces of the bones, it will soon deprive the joints of all kinds of mobility. Repeated inflammation waves deform the joint. Stones inside the kidneys often become the cause of chronic inflammatory disease - pyelonephritis, as well as problems with the removal of urine outside.

Tofus - the focus of urinary deposition

At one time, the gout suffered such famous peopleAsaac Newton, Ivan Sergeevich Turgenev, Benjamin Franklin, Peter Paul Rubens.

Acceptance of medicines is one of the main methods of treating gout. Medicines affect all process links: high level , the formation of tofuses, inflammation in the kidneys and other amazed tissues. Medicines are used to eliminate acute gout attacks and preventing the further spread of the disease.

Kings Disease - Video

Preparations for the treatment of acute gout attack

The first blow of the disease, as a rule, falls on the fine joint of the thumb. The attack is accompanied by acute pain, increasing temperature, general malaise. Externally, the joint looks changed: it is increased in the volume, the skin above it is a bright red shade, movements cause sharp pain. Such a scenario is characteristic of 50-80% of the debut of the gout. In some people, the disease begins with inflammation of other joints - knee, hip, interphalangeal, ray-beyond. In some cases, pain is uncertain. For the treatment of acute attack of gout used several groups of drugs.

Inflammation of the first finger of foot - the most common script of a sharp bunch of gout

Non-steroidal anti-inflammatory funds (NSAIDs)

NSAIDs is a whole group of drugs. It is named so because it contributes to the elevation of inflammation in the changed gout of the joint. The inflammatory process is impossible without a number of biologically active substances. Their overall predecessor is arachidone acid. Chemical transformations occur with a peculiar accelerator - the protein-enzyme cyclooxygenase. The latter is divided into two varieties. The first plays a positive role and does not participate in the inflammatory process. The second type (COF-2) leads arachidone acid along the path of transformations, as a result of which inflammation activators are formed.

All NSAIDs affect the exchange of arachidonic acid

The action of all NSAIDs is based on the cyclooxygenase enzyme blockade. These drugs simultaneously have three effects: antipyretic, anesthetic and anti-inflammatory. All three are extremely necessary with an acute attack. When goug is prescribed not all NSAIDs, but only certain drugs. Some differs from other NSAIDs The preparation of colchicine used in an acute bout of gout. It directly affects the activities of immune cells involved in the inflammation process. Colchicine prevents their penetration into the focus of uric acid deposits. The chemical component of inflammation is also blocked. In addition, colchicine has an anesthetic and antipyretic effect.

Colchicine affects the immune cells leukocytes

NSAIDs for the treatment of acute bunch of gout - Table

Drug name	Active substance	Form release	Contraindications	Price in Pharmacies	Analogs
Meloxicam	Meloxicam	pills; injection.	bronchial asthma; ulcerative disease; increased bleeding.	from 36 rubles for tablets; from 73 rubles for a solution.	Amelotex; Arthrusan; Librum; Genitron; Melbeck; Flexibon; Movix; Mova.
	Meloxicam	pills; injection; suspension for reception inside.	bronchial asthma; peptic disease; increased bleeding.	from 462 rubles for tablets; from 567 rubles for mortar; from 578 rubles for suspension.
Nimesulid	Nimesulid	Pills	bronchial asthma; peptic disease; increased bleeding; diseases of the kidneys.	From 28 rubles	Naz; Nimlex; Nimulide.
Kesetoxib	Kesetoxib	Pills	bronchial asthma; peptic disease; increased bleeding; kidney disease; liver disease.	From 180 rubles	Dilaks;
		pills; ointment; rectal candles.	bronchial asthma; peptic disease; increased bleeding; kidney disease; liver disease.	from 42 rubles for tablets; from 70 rubles for candles; from 64 rubles for ointment.	Indochin; Metindol.
		pills. gel; ointment; injection; rectal candles.	bronchial asthma; peptic disease; increased bleeding; kidney disease; liver disease.	from 59 rubles for tablets; from 28 rubles for candles; from 24 rubles for the solution.	Voltaren; Diclovit; Ortofen; Rapten; Reztan.
		Pills	severe liver diseases; heavy kidney disease.	From 1150 rubles	Kolkhikum dispert

Non-steroidal anti-inflammatory products - photo gallery

Movalus contains meloxicam Nimesil contains an active substance nimesulide Kebrex blocks cyclooxygenase Indomethacin removes heat and pain Colchicine is prescribed with an acute attack Diclofenac - Popular Anti-Inflammatory Preparation

Steroid hormones

Glucocorticoids, they are steroid hormones - another group of drugs for the treatment of acute bunch of gout. These drugs have an even more powerful anti-inflammatory effect than the NSAID. Steroids affect the work of immunity. Immune cells are dismisted in the sediment of uric acid in the joint and do not participate in inflammation. When admitting inside the medicine has many side Effects. It is more advantageous to introduce hormones directly into the focus of inflammation (intra-stool). Glucocorticoids are used with a pronounced process, intolerance to the NSAID.

Steroids have a powerful anti-inflammatory effect.

Steroid hormones for the treatment of acute gage attack - Table

Drug name	Active substance	Form release	Contraindications	Price in Pharmacies	Analogs
Betametan	Betametan	Ointment	fungal diseases; tuberculosis; immunodeficiency; HIV infection.	From 300 rubles	Beloderterm; Katerid.
Hydrotisut	Hydrotisut	ointment; pills.	fungal diseases; tuberculosis; immunodeficiency; HIV infection.	From 29 rubles	Salus Cortef.
Triamcinolone	Triamcinolone	Suspension for injection	fungal diseases; tuberculosis; immunodeficiency; HIV infection.	From 480 rubles	Berlikort; Kenocort.
		pills; injection.	fungal diseases; tuberculosis; immunodeficiency; HIV infection.	from 73 rubles for tablets; from 33 rubles for a solution.	Decortin; Medopred.

Steroids for the treatment of gout - Photo Gallery

Cortef contains hydrocortisone Kenalog is produced in the form of suspension for injections Prednisolone is prescribed for the treatment of arthritis Acrider - steroid ointment

Treatments of long-term action

After the first attack of gouts are prescribed, medications directly affect the exchange of uric acid in the body. There are two main ways to combat the high level of uric acid. The first type of drugs - uricodipressive (or uricostatic) drugs - reduce urinary acid production from its predecessor of Xanthin substance. Uricostatics blocked the action of the protein-enzyme xanthinoxidase. Under the influence of these drugs, urinary acid is formed in a much smaller quantity.

The second type of drugs affecting the level of uric acid is called uricosuric agents. They work inside the kidneys, forcing these organs more active with urinary acid with urine. Pharmaceutical companies also created mixed action preparations that simultaneously reduce the production and improving uric acid removal. In addition to these two types of drugs, uricolithic agents are prescribed. These drugs give the urine alkaline reaction. Under conditions of conventional acidic medium, urinary acid is inclined to fall into the precipitate, forming small crystals and larger concrections. One of the manifestations of the gout often becomes stones in the kidneys and ureters. Uricolithic preparations prevent the formation of the uric acid of the sediment and the further growth of the concrections.

Preparations for main treatment of gout - Table

Drug name	Active substance	The form release	Contraindications	Price in Pharmacies	Analogs
Urikodepressants
		Pills	intolerance active substance; liver disease; renal failure; pregnancy.	From 75 rubles	Parinol; Allopurinol Egis.
Tiopurinol	Tiopurinol	Pills	intolerance of the active substance; liver disease; renal failure; pregnancy.	From 150 rubles	No analog
Ortic acid	Ortic acid	Pills	intolerance of the active substance; cirrhosis of the liver; renal failure; urolithiasis disease.	From 100 rubles	Magnesium orotat.
Urricauric means
Samples	Samples	Pills	urolithiasis disease; liver disease; diseases of the kidneys.	From 4500 rubles	Santuril; Biocanol probenecide.
Sulfinpyrazon	Sulfinpyrazon	Pills	peptic disease; renal failure; blood diseases.	From 500.	Apot-sulfintizon; Anthurore; Antornil.
Benzbromaron	Benzbromaron	Pills	kidney disease; urolithiasis disease; pregnancy.	From 1615 rubles	Dizurik; Normurat; Hipric.
Mixed action preparations
Almaron	allopurinol; benzbromaron.	Pills	hypersensitivity; kidney disease; lactation; pregnancy.	From 58 rubles	No analog
Uricolithic means
	piperazine; urotropin; sodium bicarbonate; winnocamean acid.	Granules for receiving inside	hypersensitivity; pregnancy; diabetes.	From 500 rubles	Urozin; Atofan.
	Potassium sodium hydrocente	Granules for receiving inside	renal failure; chronic pyelonephritis.	From 871 rubles	SOLURA.

Preparations for long-term gout therapy - Photo Gallery

Allopurinol - Popular Means for Gout Potassium orotat reduces uric acid production Blemarin prevents the fallout of uric acid into the sediment Urolon is prescribed when goug Urodanes produced in the form of granules

For several years, I observe the flow of gout from my relative. As far as is known, this is the first case of gout in the family. It himself is distinguished by overweight and adding to meat products. The first attack of the disease at the age of 50 years flowed on a typical scenario: suddenly blushed thumb On the leg, there was a strong pain and an increase in temperature. You could only step on the leg with great difficulty, overcoming painful feelings. The acute attack removed Indomethacin in combination with Moviess. Biochemical analysis Blood showed a high level of urea. Therapist in the clinic prescribed allopurinol and adherence to the diet. The rejection of meat products for my relative was a heavy choice, but he tries to not violate the diet. The use of beer and other alcohol also had to forget. Reception of drugs and diet led to the fact that the exacerbations of the disease over the past 5 years have happened more than once a year.

The use of a "Colchicine" medicine in the therapy of gouty arthritis will allow you to quickly and effectively eliminate pain syndrome and inflammation, restore the volume of movements in the joint. Regular periodic courses will avoid recurrences of gout in patients with chronic flow illness.

Composition, form of release and mechanism of work "Colchicine"

Therapeutic effect The drug is achieved due to its main valid element - colchicine. This substance has vegetable nature and is an alkaloid, mined from the bulb of a unlimited ordinary. The drug is implemented in the form of a tablet covered tablets. Each of these contains 1 mg of the active component. Total in packing 20 pieces. Quickly absorbing in the gastrointestinal tract, the medication reduces the intensity of the movement of white blood cells to the hearth of inflammation, and also stops the process of absorption by cells of uricular microcrystals. It has the ability to reduce urinary acid products and prevent its crystallization. The medicine is inhibited cell division and stops the formation of defective amyloid protein elements.

2 hours after receiving the "colchicine", the sick gout feels a sharp improvement in the state, which is stored for 12 hours.

Ailments in which the drug helps

The drug will bind pain during an attack of the disease.

Tablets "Colchicin" have a quick positive impact When stopping sharp gout attacks. Regular reception allows you to reduce the likelihood of recurrence in most patients. The list of readings for the use of the medication includes such pathologies:

• violation of the exchange of protein - amyloidosis;
• aphtose ulcers of mucous membranes - Behanet syndrome;
• inflammatory dental and LOR-Diseases;
• calcium deposits on articular cartilage;
• hardening connective tissue - sclerodermia;
• inflammation of venous walls;
• family Mediterranean Fever.

How to take "Colchicin" in the treatment of gout?

The drug intake scheme is prescribed individually and depends on the form of the disease and severity of the patient's condition. The drug is intended for oral administration, it is possible to take it independently of food, preferably in the evening. You can not drink more than 8 mg per day. Dosage for the treatment of gout and different, more about it in the table:

In which cases, the reception of the drug is prohibited?

The means is contraindicated in the presence of kidney disease.

To refrain from therapy "Colchicine" stands to persons with individual intolerance suffering from alcoholism, as well as elderly people. You can not drink medicine during pregnancy. The reception of "colchicine" is excluded in gout therapy at the following background pathologies:

• acute lack of liver and kidney function;
• severe digestion, heart and blood vessels, bone marrow;
• purulent infections;
• agranulocytosis.

Side Effects of "Colchicine"

Reception of the drug can provoke unwanted reactions from various organism systems. The unpleasant sensations are in most cases under the reduction of the dose of the medication. If the symptoms are intense - you need to refer to the doctor for replacement. List of possible side phenomena:

• dyspeptic manifestations: epigastric pain, no appetite, nausea, vomiting;
• violation of the liver and kidney work;
• deviations in the composition of blood;
• allergic rash on the skin;
• hair loss;
• neuropathy;
• depressive condition;
• muscle damage;
• lack of vitamin B12;
• lack of spermatozoa.

The treatment of "colchicine" must be carried out under the control of blood indicators through regular analyzes.

Colchicine for gout is an effective medicine to relieve the exacerbation of the disease. It has a number of contraindications and side effects. The drug is insecable and can cause the development of complications, so it is necessary to consult with the attending physician before starting receiving tablets.

In the acute development of the gout and the inflammatory process, it is shown to take 1 tablet 3 times / day on the first day of therapy, the preventive course provides for receiving 1 tablet in the evening for 12 weeks

Form of release of medicine from gout colchicine - tablets. In one tablet contains 0.5 or 1 mg of the active substance, colchicine (the alkalid alkalid alkalid). Colchicine is a small white tablet covered with film shell.

The following auxiliary components are present in the composition:

• lactose monohydrate;
• starch;
• aerosil;
• castor oil;
• the components of the shell and dyes.

The drug is produced in packages of 20, 40 and 60 tablets.

Pharmacological properties

The drug refers to the means affecting the exchange of uric acid in the body. pharmachologic effect It is due to a decrease in the rate of migration of leukocytes to the heart rate, which allows you to quickly and effectively stop the inflammatory process. Simultaneously with the decrease in inflammation, the drug reduces the rate of sedimentation of uric acid microcrystals in the joints, thereby reducing the risk of developing new exacerbations of gouty arthritis.

The peculiarity of the treatment of gout by Colchicin is fast action Medicines. After taking the tablet, the maximum concentration of the active substance in the blood plasma is reached after 120 minutes. Pills from gout colchicine quickly reduce symptoms. After receiving the first therapeutic dose, a noticeable improvement in well-being occurs with a maximum of 4-5 hours.

Indications for use

Indications for the use of colchicine at gout are an exacerbation of gout arthritis and prevention of disease progression.

When gouty arthritis, the reception of colchicine allows you to quickly reduce the severity of pain syndrome and stop the inflammatory process.

Receiving tablets with gouty arthritis improves overall health after a few hours.

Colchicine can be used not only during recurrence or exacerbation of the gout, but also for the prevention of gogress arthritis. In addition, the medicine can be used in the composition complex therapy Gouts, since it does not enter into negative interaction with allopurinol used to reduce uric acid concentration when goug.

Contraindications and restrictions

From the reception of the drug should be refused if there is individual intolerance

The drug has enough contraindications. These include:

• the intolerance of colchicine;
• lactose intolerance;
• hemodialysis;
• discrasion (change of composition).

With violation of the liver and kidney function, a decrease in the recommended dosages given in the instructions for the drug is shown. Elderly patients can also be recommended to reduce the dose of the drug in the first weeks of reception.

Pregnant women medicine is not appointed, data on the effect of colchicine on the body of pregnant women is not enough. This is primarily due to the fact that the gout is a male disease affecting people over 50 years old. In women, the gout occurs very rarely, and only after the onset of menopause. For the same reason, the drug is not used in pediatric practice.

How to take colchicine when goug?

The therapy gout with colchicine should be consistent with the doctor. The cure for gout and gouty exacerbations of colchicine is usually accepted according to the instructions, however, on the recommendation of the attending physician, the reception scheme can be changed.

When the gout exacerbates, one tablet of colchiscin should be taken at once in a 1 mg dosage, and then take half a tablet every three hours, or a drug in a 0.5 mg dosage.

Maximum daily dose when aggravating gout - 6 mg of the drug, for the prevention of relapses - 1.5 mg.

The treatment of exacerbations is carried out until the symptoms descend. Then a three-day break is made and the course can be repeated if the inflammatory process has not passed. In the case when inflammation was successfully stopped, the treatment continues in a few days, taking 0.5 mg of colchicine three times a day.

If the intake of gout is accompanied by sharp pains, how to take colchicine from the gout, the doctor defines. As a rule, a rather short course of treatment with large doses of the drug is practiced. Preventive medication is carried out within three months.

The tablet must be taken immediately after eating, drinking sufficient water. You should not chew the medicine, the tablet swallowed entirely.

Side Effects and Overdose

When adopting the drug may occur such unpleasant symptoms as pain in the stomach and diarrhea

The use of colchicine at gout may have the following side effects:

• nausea and vomiting;
• stomach ache;
• diarrhea;
• muscle weakness;
• gastric bleeding;
• general weakness;
• skin rash;
• convulsive seizures;
• alopecia (baldness);
• peripheral neuritis;
• blood breeding;
• inhibition of bone marrow.

With intolerance to the drug, symptoms of an allergic reaction appear. As a rule, it is manifested by a wretched skin, skin swelling, strong itch. Long use Large doses of the drug may adversely affect the functions of the liver and kidneys.

When any alarming symptoms appear to consult a doctor. Be sure to call " ambulance"When acute pain in the stomach or diarrhea with blood.

In case of overdose of the drug, convulsive seizures may appear, develops internal bleedingIt is possible to loss of consciousness and oppression of the kidney function. In this case, it is necessary to cause emergency medical care as soon as possible.

The drug should be cautious to appoint elderly patients. People whose organism is strongly weakened by recently transferred diseases, it is recommended to refrain from taking the drug. The following states require a reduction in dosage or a drug intake under the doctor's control:

• heart diseases;
• disorders of the kidney and liver;
• respiratory failure;
• bone marrow disorders.

Small doses of the drug do not affect the work nervous system. During the exacerbation, the reception of large doses of colchicine is prescribed, which can adversely affect the reaction rate, so it should refrain from managing vehicles.

Important! Colchicine is incompatible with alcohol, at the time of treatment it should be completely excluded alcohol.

Before starting the medication, you should carefully examine drug interactions.

1. Tiazide diuretics often increase the level of uric acid in the blood plasma. With a simultaneous reception, the action of the colchicine will appear weakly.
2. Colchicine breaks the process of absorption vitamin B12.
3. Simultaneous reception with cyclosporin is not recommended, as it increases the risk of muscle damage, which can cause hypotonus or convulsions.
4. Erythromycin increases the activity of colchicine. It is dangerous to the development of body intoxication due to high concentrations Colchicine in the blood.
5. Colchicine must be taken with caution simultaneously with non-steroidal anti-inflammatory means due to the risk of leukopenia.

The drug can be taken with other drugs intended to reduce uric acid levels in the body (ALALLURINOL). Accurate dosageThe diagram of reception of drugs and the duration of the course of treatment determines the doctor individually.

Cost and analogs

Tablets Kolkhikum-dispert are accepted inside, dosage form powered by water, dosing with acute attack - 2 tablets at the beginning of therapy, then every two hours another 1-3 tablets

Colchicine has recently been difficult to find in Russian pharmacies. The average price of the drug is 500 rubles per package of 20 tablets. The drug is released strictly according to the recipe, so the doctor must appoint it.

Full analogues of the drug - Tablets Kolkhikum-Dispert, Colchine, Calchician. These drugs have the same composition, the form of release, dosage and features of application. Medicines with another composition, but similar effect does not exist. If the patient did not come up with colchicine, it is necessary to consult with the doctor about the possibility of replacing the drug. With the intolerance of this substance, the patient can be shown special medical diet and taking allopurinol.

It should be noted that the drug contains an alkaloid, which can cause a strong allergic reaction. In addition, in the composition of the tablets there is a monohydrate lactose, so when lactose intolerance, the reception is prohibited.

With the appearance of allergy symptoms, it is necessary to stop taking tablets and consult with the doctor about the further diagram of the gout treatment.

With such a disease, as a gout, treatment of drugs is aimed at removing symptoms, extension of the period of remission, reducing the number of exacerbations. Funds are used both systemic and local action. How to treat gout on the legs?

Table of contents [show]

Power treatment

Continuous reception of minimal doses of colchicine helps to reduce the frequency of attacks, the greatest effectiveness of such therapy has the most imbinding and polyarticular forms of the disease. Continuous treatment does not contribute to addiction, and the drug retains its effect when the acute type of gout occurs. Colchicine can cause leukopenia and anemia, so general analysis Blood is recommended no less than 1 time in 6 months.

From the gout preparations of the hypovering group, it is rapidly eliminated, which is associated with the impact not on the symptoms, but for the cause of the disease. There are 2 types of similar funds:

• displaying increased amount of uric acid through the kidneys
• thoring production of this substance.

The first prevent the suction of urea into the blood, they turn out to be ineffective in the presence of renal failure. Uricauric pills are most often used to treat chronic gout.

The probebox blocks the processes of tubular absorption of the urate and increases the amount of uric acid isolated by kidneys. Tablets are accepted in minimal doses 2 times a day, a week later, the dosage is increased by 2 times. The drug has no serious side effects, It is easily transferred by the body. In rare cases, a strengthened sweating may be observed, allergic reactions and decline arterial pressure. Permanent monitoring of the state of the excretory system is necessary. When the first signs of renal failure, the probenecide is replaced with allopurine. ETebenecid has similar effects, many experts believe that it gives less side effects.

Allopurinol refers to the preparations that slow down the production of uric acid. The dose is selected by the attending physician. Starting recommended with minimal, gradually increasing it. Tablets take 2-3 times a day, the treatment of gout on the legs lasts 3-4 weeks. Allopurinol can be used in combination with a colchicine. The first preparation is well tolerated, in rare cases there are allergic reactions, skin rashes, neuritis.

The therapeutic effect of allopurinol is due to the impact on enzyme, converting hypoxanthin in urinary acid. The use of this tool does not lead to salts, so it can be cured with the gout without the risk of nephrolithiasis. Allopurinol has a pronounced anti-inflammatory effect. He relieves pain and swelling, eliminates the redness of the skin.

Indications for the use of the drug are:

• the presence of large salt sediments;
• acute gout attack, which cannot be stopped using standard uricosuric drugs;
• intolerance of a probelexide;
• developing increased quantity uric acid;
• merrate nephrolithiasis;
• chronic and acute renal failure.

Some experts believe that these pills can cause xanthine lithiasis. Comprehensive medicia treatment Gout can make rid of the patient from the attacks for a long time, but it does not eliminate disorders in metabolism processes, so the therapeutic course can last several years, and even for life. The abolition of drugs contributes to a rapid increase in uric acid level in the body, and the pain may appear again.

A smaller number of side effects have NSAIDs, which eliminate pain during acute gouty attacks. The most effective is the preparations of pyrazolone series. During the exacerbation of the tablet takes every 6 hours in maximum doses. However, even in this case, the NSAIDs cause less pronounced side effects than colchicine. When appearance unwanted consequences One tool can be replaced by others, which increases the effectiveness of treatment.

If the tablets described above are ineffective, the attending physician may decide on the appointment hormonal drugs, rapidly eliminate symptoms of the disease. You can cure the gout using a single injection or a brief therapeutic course. Hormones remove arthritic manifestations and pain.

The attack of gout significantly worsens general state The patient, glucocorticosteroids allow you to return to the usual lifestyle in 2-3 days.

Outdoor Means from Gout

Mazi and solutions allow to eliminate pain and inflammation, remove the swelling and restore the mobility of the joint. Butadion-based cream is applied to the affected area 3-4 times a day.

Begin treatment is necessary with minimal doses of the active substance. This will help avoid severe allergic reactions.

The tool is treated with skin without rubbing it. In the application of the warming bandage there is no need. However, it is necessary to protect the feet from the impact of direct sunlight. Diclofenac ointment is considered no less effective. 1 g of this drug contains 10 mg of active substance. A small amount of ointment is evenly distributed over the skin of the affected area. It is rubbed with light massage movements. With strong pressing or making sharp action, pain may increase.

During the day, ointment is applied 2-3 times, its total amount should not exceed 8 g. Nonteroidal anti-inflammatory substances can penetrate into the blood, which leads to the appearance of side effects. Safe and efficient gout drugs are made on the basis of natural vegetable extracts. These include Fulflex. It can be used in the presence of allergic reactions to chemicals. Ointment has a pronounced anti-inflammatory and anti-ethnic effect.

Preparations of systemic and outdoor action should be selected by the attending physician.

Gout, or gout arthritis, is a disease that affects human joints due to salt deposits. Despite the very familiar name on a hearing, sick of the gout of three people out of a thousand. In the age criterion, the disease occurs in people over 40 years of age, there are no men and women in the sexuality of separation - gout. The most common location of the disease on the human body - the fingers of the feet

The reasons

Preceded the development of gouts can many factors. Among people entering the risk group - persons suffering diabetes and hypertension. The disease has an inheritance property, so it is worth considering the hereditary factor. The gout of the feet may arise due to the excessive load that the feet are experiencing. More severe arthritis of the feet are sick of elderly. In addition, unbalanced nutrition and, as a result, the disturbed metabolism in the body may affect the development of gout and aggravate it. Not only these factors will affect the fact that the medicine from gout will be most effective in treatment, but and what symptoms accompany the disease and what extent it has reached.

Symptoms for gout

The disease may not yet file any signs and manifest itself completely suddenly, while with very tangible painful phenomena. The main symptom of the originless disease is swelling and increased temperature In the area of \u200b\u200bthe sore joint. In most cases, heat and severe pain notify about themselves at night. Moreover, the joint is so sensitive to any touch that even a light sheet can cause acute pain. Subsequently, a feeling of tingling is added to a strong pain and feeling of heat in the joint.

If you ignore this symptoms and do not take any attempts of treatment, the attacks will appear increasingly, and the disease will affect all new areas of the joints. The launched stage of gout arthritis often leads to such complications in the human body as kidney disease and urinary tract.

Despite the latest technology in pharmaceutical and the effectiveness of treatment, it is impossible to completely overcome the gout, it acquires chronic formBut it is possible to alleviate the condition and slow down the development of gout using true selected tablets.

Power treatment

The symptoms indicating the possibility of the disease must, first of all, provoke a person to the campaign to the doctor. Appointing an appropriate examination and confirming the diagnosis, doctors in accordance with the degree of disease are prescribed to the patient medicationswhich have a multidirectional action. Pill tablets should have a minimum, a three-component effect - the operational elimination of painful sensations, preventing possible attacks, suspension of long-term complications.

Each person neglecting the treatment regimen is responsible for his own health and life. The refusal to receive medicines leads to the destruction of the kidneys and further damage to the joints. Correct treatment, the fulfillment of all the instructions of the doctor leads not only to eliminate pain, but also to the possibility for a long time or, perhaps forget about it forever.

Drugs from gout

To date, despite the development of medicine and the latest technologies in the manufacture of medicines, there is not so many drugs used for the treatment of gout. In terms of its action, they are classified for temporary preparations and long action. Short-term drugs allow you to quickly remove pain. With the elimination of attacks, painkillers are struggling, anti-inflammatory drugs that have not only analgesic effects, but also eliminate the focus of inflammation.

In turn, long-term drugs helps to remove not so much painful sensations as reduced the level of uric acid in the blood plasma and, as a result, slow down the development of the disease and eliminate complications.

Colchicin

In modern medicine, Colchicine is one of best medicinesused to combat gout. The drug refers to the alkaloids of a tropan series and has an analgesic effect, and also neutralizes the formation of salt sediments in tissues and minimizes the migration of leukocytes in the damage zone. The drug was created on a vegetable basis, containing in its composition the main component is a non-laminate of autumn, so it can be applied not only with therapeutic, but also with a prophylactic goal.

It is well tolerated by patients, and in addition to the therapeutic effect has high rates Safety for health. Efficiency The drug largely depends on the correct reception. As soon as the disease is diagnosed, colchicine should be taken in the first day every hour. It should be borne in mind that the maximum daily dose should not exceed 10 tablets. The course of treatment with a colchicine ends when the desired result is achieved and by appointing a doctor.

As fairly effective medicine, affecting and excreted by the kidneys, it is contraindicated to people with renal and liver failure, as well as with individual intolerance to the components of the drug. It is worthwhile to take colchicine during pregnancy and only after the permission of the doctor. Overdose of the drug or the presence of contraindications may aggravate the condition and cause vomiting, diarrhea. The emergence of other side effects should force a person to refuse immediately from taking medication and consult a doctor. In addition, the drug should not be taken for a very long time. In this case, he may cause the threat to the development of anemia and leukopenia.

Allopurinol

Allopurinol does not help relieve pain, but, in turn, it reduces the uric acid indicator, and also serves as a protective barrier to possible complications gout. Treatment should be started with a minimum daily dose - 100-300 mg, which must be divided evenly during the day for 3 receptions. On the recommendation of the doctor and the absence of side effects, the dosage can be increased - up to 100 mg every two weeks. At the same time, the maximum daily dose should not exceed 800-900 mg. Therapeutic effect can be achieved with proper treatment Without passing the tablets during the first month of the drug, considering that the daily dose should not be less than 200-600 mg.

Patients accepting Allopurinol, each month it is necessary to test the blood test, which determines the level of uric acid. By the way, the decline in this indicator will already be noticeably in the first month of treatment.

Despite wide action The drug, its use should be appointed by a doctor with special care. A person should not have other concomitant diseases that may be aggravated by the reception of Allopurinol. In addition, it is contraindicated in hepatic insufficiency and during the period of a gout.

Alopurinol's analogues serve Tiopurinol, Anthourane and Hipurik.

Fulflex

The best of its kind is very popular and recently constructed the drug Fulflex. It is convenient because it is produced in two forms - in the form of cream and tablets - and allows you to fight the disease not only from the inside, but also outside. The drug refers to the means of short-term action and has a simultaneous, analgesic and anti-inflammatory effect. The composition of the medicine includes extracts of such plants as martinia fragrant, bark willow, bark bark, horse chestnut, and also essential oils Eucalyptus, sage and juniper, which is largely safe to affect the human body. In addition, among its components vitamins E and PP. By the way, Martinia is fragrant is used for a long time as a means that struggling with inflammation and edema on certain areas of the body. Especially widespread use is this plant in the east.

Reception The drug is designed for a month in the calculation one tablet per day, the cream is rubbed twice a day. Fulflex is contraindicated in pregnant and lactating women.

Voltaren

Temporary stopping of seizures of gouty arthritis is possible with the help of the actual type. The effect is achieved by simultaneously receiving tablets and ointment of this drug. To achieve an explicit result, it is recommended to take on the first day. maximum dose - 200 mg, subsequent - 150 mg in the knocks, as well as twice with a sick joint with cream.

Such an action has ibuprofen and diclofenac, which remove inflammation, allow you to remove the swelling and pain, and also reduce the temperature. The same scheme adheres to naproxen. All these means are strictly contraindicated during pregnancy.

The effectiveness of treatment, up to the elimination of all sorts of attacks subsequently, largely depends not only on compliance with dosage norms, but also on duration. It will be extremely inappropriate to stop drug therapy in the disappearance of symptoms and confidence that the disease has retreated. Even when the pain is stopped, the drug should continue to accept until the end of the course. Conference, lack independent treatment Without observation, the doctor will allow enough to deal with the gout, forgetting about the pain forever.

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Gout - Some of the types of arthritis. The gout arises due to the accumulation of uric acid in tissues, which, in normal functioning, the kidney should be derived from the body along with the urine. Symptoms gout are strong painfulness In the joints, their redness and sensitivity to touch. The disease may be accompanied by swelling of the joints.

For people suffering from gout, you need to combine drug treatment and a special diet, eliminating some types of products to prevent the attacks of the disease. For more information about the diet, see the article "Diet when goug."

The most efficient drugs for the treatment of gout are Fulflex, Allopurinol and Colchicine.

Fulflex

The drug has wide spectrum Actions, anesthetics, gives an anti-inflammatory and anti-empty effect. Well relieves pain during the attack of the disease, contributes to the removal of uric acid from the body. Fulflex also reduces blood cholesterol and has a diuretic effect.

Such an effect is achieved by components included in the drug: Martini extracts of fragrant, toles of the viscous, birch, yawa bark and horse chestnut, juniper essential oils, sage and eucalyptus.

All components of the drug have a plant basis, which ensures the safety of its use.

Fulflex is prescribed both inward in the form of capsules, and externally in the form of a cream for rubbing into the affected joints.

Reception capsules is prescribed once a day while eating. The duration of treatment is one month.

Outwardly, the drug is used twice a day, rubbing with circular motions into a sore joint.

The drug is contraindicated in women in a state of pregnancy and during breastfeeding.

The side effects of the drug was not detected.

Allopurinol

Allopurinol is used in the treatment increased content uric acid and gout. The main active component of the drug - allopurinol accelerates the oxidation of xanthin, which contributes to its conversion into urinary acid.

The drug is prescribed for intake, depending on the severity of the disease. With a slight course of the disease, the daily dose of the drug is 100-200 mg, 400-600 mg are prescribed for patients with a middle form of gravity; severe course Diseases - 900 mg per day. The positive effect of the drug on the body is noticeable for a day or two after the first reception. The dynamics of the drug is monitored by comparing the uric acid level before and after the adoption of the drug.

The possibility of treatment with allopurinol is not always there, if a person has a disease. At the beginning of treatment, the doctor must closely monitor the condition of the kidneys and the liver of such a patient. If the kidney function is reduced, then the dose of the drug is recommended to reduce twice.

When treating the drug, the volume of urine allocated from the body should reach two liters per day.

The drug is contraindicated in pregnant and nursing women.

Possible side effects from the reception of alloparol: arterial hypertension, Bradycardia (low heart rhythm), stomatitis, nausea, vomiting, disorder of digestion, dizziness, headaches, weakness, sleep disorder, depression and urticaria. In rare cases, the reception can cause swelling and blood release along with urine (ureia and hematuria).

Allopurinol does not remove pain in gouty attacks, but contributes to their disappearance in the future.

Take the drug is necessary for the recipe and under the control of the doctor.

Colchicin

The drug has vegetable origin and is an effective means for removing pain during the gout seizures. Get colchicine from the unscrewed autumn.

The drug is taken during an attack of gout inside, in a dose that does not exceed 1 mg. Two hours later, the reception of colchicine repeat. The positive effect of the drug occurs three hours after the reception and lasts twelve hours. The prescription of the drug is more than this dose. It is possible only after a medical examination, but the reception of more than 10 tablets is not recommended during the day.

Colchicine is safe for the body, one part of the drug is absorbed from the intestine, the other part is processed in the liver and is derived from the body.

Contraindications for use: hepatic or renal failure, hypersensitivity to drug components.

Reception of the drug with pregnant women should be carried out under the control of the doctor.

The drug has side effects that occur usually in overdose: nausea, vomiting and disorder of digestive organs, itching, urticaria, burning skin, reduction of the number of leukocytes (leukopenia) or neutrophocytes (neurosition) in the blood, sperm deficiency (CSU men).

Allopurinol is a drug that effectively reduces the concentration of uric acid. As a result, its deposition is preventing bladder bubble, kidneys, joints. Urolithiasis refers to the most famous illness. Stones in the kidneys and bladder have different nature, therefore the treatment regimen is selected individually.

The medication prevents the increase and depositing of ultrasters. The instruction indicates that it is able to disrupt the uric acid formation mechanism. With the help of a medicine, Xantina oxidase is suppressed.

"Allopurinol". Dosage and composition

You can find a drug in two types: Allopurinol 100 and 300. As part of:

• 1-H-pyrazol- (3,4-D) -pyrimidin-4-ol or allopurinol - in a dosage of 100 or 300 mg.

• Auxiliary substances: magnesium stearate, lactose, starch, polyvidone, talc, sodium amylopectin glycale.

What diseases are appointed?

The drug "Allopurinol" is prescribed at:

• gout;
• renal disease;
• lymphosarcoma, acute leukemia,
• chronic myelolekosis;
• traumatic damage;
• cytostatic and radiation therapy;
• lesha Niena syndrome;
• massive glucocorticoid therapy;
• mushy Nephropathy.

At the beginning of the course, a minimum dose is prescribed - 100 mg to reveal side effects and possible complications to the means "Allopurinol". If no negative reactions are, the dosage of the drug is calculated by uric acid in the blood. After that, its stepwise 100 mg is raised.

Side effects

The drug "Allopurinol" the side effects appear:

• anemia, agranulocytosis, leukocytosis, thrombocytopenia;
• increase hell, bradycardia, pericarditis;
• acute renal failure, proteinuria, reduced potency, peripheral edema;
• reduced vision, loss or perversion of taste sensations, amblyopia;
• nausea, vomiting, diarrhea, cholestatic jaundice;
• neuropathy, headache, drowsiness, depression;
• allergic reactions.

Contraindications

It is not prescribed when unnecessary to allopurinol or additional components. It is prohibited by people with damage to the liver, renal dysfunction, an acute bout of gout, primary hemakhromatosis, pregnant and nursing women.

Price

Cost this drug from 80 to 100 rubles. Depends on the region and pharmacy network.

Reviews

About medicine mainly positive feedback. Effective with urolithiasis, removes urates from the body. Prevents their new deposits. Most often it is well tolerated, side effects, if they appear, then in the form of an increase in blood pressure. Available at a price.

"Allopurinol". Analogs

The drug "Allopurinol" has more than 14 analogues. And this means that patients who have identified the doctor have the right to choose. The main indications for the reception of all the drugs below include not only the treatment of gouts, but also excessive accumulation in the blood of uric acid (hyperuricemia) of the most varied genesis.

Also, the testimony includes a combination of gout with uranium nephropathy, renal failure, nephrolityiasis. Another indication is the increased formation of urates due to the presence of enzyme violations. In addition to therapy, this drug can also be applied to the prevention of nephropathy during the treatment of cancer, as well as complete medical starvation.

For each form there is its own side effects that are not too much and their manifestation is quite rare, but they need to know about them. For example, the most common: increased fatigue, diarrhea, weakness, baldness, violation of blood composition. This confirms the instruction on Allopurinol to preparation.

"Hello"

One of the most popular and well-known analogues is "Hello", which has the same active ingredient as "Allopurinol", and therefore can rightly be considered a complete substitute. Dosing depends on what state is the patient. For example, if the symptoms are weakly expressed, the inside should take 200-300 mg per day, and if the symptoms are pronounced, then 400-600mg per day. Tablets take 2 times a day after or during meals, for example, immediately after breakfast. Other data, including side effects, contraindications and indications, correspond to the original drug completely.

What else do Allopurinol analogues exist?

"Allupol"

"Allupol" is another analogue of Allopurinol, also produced in tablets and having the same international name and active substance. But before replacing one drug to others, you should consult with a specialist. The minimum daily dose is 100-200 mg of the drug, and the maximum - 900 mg. Exceeding the specified number is not recommended under any circumstances. The use of "Allupola" is contraindicated to patients with liver and kidney disease. During the course of treatment, it is necessary to carefully monitor the functioning of these organs.

"Zilirik"

Zilirik is a generic, a foreign analogue of Allopurinol. Its value exceeds the price of domestic drugs several times, although the composition and indications for use are completely coincided with the Russian drug. The initial dosage usually does not exceed 300 mg for a light degree of the disease, 600-800 mg are prescribed at a severe stage. Elderly patients and people with kidney diseases must take the drug strictly individually according to the dosage prescribed by the doctor or replace it with medicine, which is based on another active substance.

There are other analogues of the Allopurinol preparation.

"Milrit"

"Milurite" is a fairly popular foreign substitute for the original medication, but it is difficult enough to find in pharmacies.

Analogs for the treatment of gout: "Sanfipurol", "Allozy", "Remid", "Allopin", "Parinol", "Allopurinol Nikomed", "Apo-Allopurinol", "Allopurinol-Teva", "Allupol", "Allopurinol-Egis "

The cost of drugs depends on the number of tablets in the package and dosage, but on average it ranges from 65 to 150 rubles. One of the most purchased and frequently appointed dosages is 100 mg. But patients with a progressive disease or his heavy form, the purchase of the tool is unprofitable, since the dosage of it is too small, and to obtain the required number of active substance in 600-900 mg, it will be necessary to drink 6-9 tablets immediately, and it is extremely uncomfortable. Therefore, patients in need of greater dosage are recommended to preparations in the amount of 300 mg. However, if a package with a dose of 100 mg contains 50 tablets, in the package with 300 mg of only 30 tablets.

We call a few more analogues of Allopurinol.

In the list of substitutes there is a well-known drug "Allopurinol-Egis", produced in Hungary by the pharmaceutical company EGIS. This manufacturer is considered a leader in the production of gout treatments.

The popular generic manufacturer is pharmaceutical company Germany "Sandoz", producing medicines that do not differ in composition from the original.

Another world-famous manufacturer of generics is Teva, which produces cheap analogues of the original drugs.

"Colchicin"

Preparations similar in action with "Allopurinol" and used as its substitute, but not at the same time its analogs are presented below.

For modern medicine "Colchicin" is one of the best preparationsthat are used to treat gout. Let's figure it out what is better - "Colchicine" or "Allopurinol"?

"Colchicine" acts as an anesthetic, neutralizes the formation of salt sediments in the tissues and minimizes the migration of leukocytes in the damage zone. The medicine has a plant basis, as the main component contains an autumn non-laminate, and therefore it can be used not only for treatment, but also for prophylaxis.

Patients suffer it quite well. The effectiveness of the drug depends on the correctness of the reception. The maximum dosage should not be more than 10 tablets per day. The course of treatment is completed by the appointment of the doctor and after reaching the desired result. "Colchicine" can not be taken to patients with hepatic and renal failure, with hypersensitivity to a component of the drug. It should also be taken with caution during pregnancy and only after consulting a specialist. Side effects and overdose of medication can cause diarrhea and vomiting. If the patient appears atypical side effects, it is necessary to immediately cancel the reception of the drug and consult with the attending physician. The drug cannot be taken for a long time, since it is fraught with the threat of leukopenia and anemia.

"Fulflex"

Recently, Fulflex is a fairly popular drug. They produce it in 2 forms - tablets and cream - which allows you to treat the disease both outside and from the inside. The medicine refers to means having a short-term action and an anti-inflammatory and analgesic effect. As part of drugs Extracts of juniper and sage, fragrant martinia, Eucalyptus essential oils, Cora Willow, Konsky Chestnut, Bark Bark, Vitamins RR and E.

Other substitutes

You can temporarily stop the attacks of gouty arthritis with the help of "Volynten". Simultaneous reception of tablets and ointments helps to achieve maximum effect. On the first day, the drug is accepted in the dosage of 200 mg, and then 150 mg per day, and the ointment is tricious with a sore joint 2 times a day.

A similar action is provided by diclofenac and ibuprofen, which reduce the temperature, relieve pain, swelling and inflammation. The same reception scheme is used for "naproxen". All these drugs are prohibited for use during pregnancy.

How effective will be the treatment, depends on the duration of the reception and compliance with the dosage standards. It would be not difficult to stop therapy after the disappearance of the symptoms. Even after painting pain, the drug must continue to take until the end of the course. Under the compliance with the scheme, it is possible to cope with the disease quite efficiently, forgetful about pain forever.

We reviewed analogues to Allopurinol preparation, price, reviews, instructions for use.

Introduction

Gout - This is a disease associated with excess

uric acid

in the body and the deposition of its salts in the tissues (mainly in

both joints).

Currently, it is impossible to fully heal the gout. This disease is forced to conduct a constant reception of medicines throughout life. Long-term reception of drugs normalizing the level of uric acid in the blood is the main principle of the treatment of gout, because the abolition of drugs leads to the resumption of attacks of the disease.

There are two directions for the treatment of gout:

• treatment of acute bunch of gout;
• continuous counterpart treatment.

Treatment of acute suppressions of the acute attack of gout is carried out by non-steroidal anti-inflammatory drugs, glucocorticoids, colchicine.

The choice of drugs for the treatment of acute attack of gout depends on the severity of the disease, from the presence of concomitant pathology, the availability of complications chronic diseases, allergies and individual tolerance of drugs.

During an acute bunch of gouts, it is necessary to provide a sick leg (hand) an exalted position and complete peace.

Nonteroidal anti-inflammatory drugs

Nonteroidal anti-inflammatory drugs in the treatment of gout are robe, butadion, Pirabuton, Villapin,

Indomethancindicloofenak

and others. Institute of Rheumatology Academy of Medical Sciences of Russia Recommended Appointment

Nimesil

(Nimesulda) for the treatment of acute gout

As a highly efficient and well-portable drug. The drug has a less pronounced compared to other drugs of this group, toxic effects on

Kidney. Nimesil (nimesulide) can be used inside and intramuscularly, and is a drug for the treatment of gout. A more pronounced anti-inflammatory and anesthetic effect is observed when the granulated nimesulide form is prescribed compared to tablet.

Colchicin

Colchicine - is widely used in Europe. The drug is a bulb extract

meadow. Previously, high doses of colchicine were prescribed, but such a method of treatment had a number of complications (

renal failure

Reactive

other). Now apply an alternative scheme for the treatment of colchicine (small dosages of it), they get a good effect and good tolerance of the drug even with the presence of renal pathology in the patient.

In the ineffectiveness of non-steroidal anti-inflammatory drugs and colchicine or conclusions, glucocorticoids are used to their intended purpose.

Glucocorticosteroid hormones

Hormonal preparations (glucocorticosteroids) are recommended to be used as 1 or 2-fold intravenous administration (depending on the severity of the process and the number of affected joints) of methylprednisolone (methipred). Also also can be used

Prednisolondexameton

Presenice, Reozolon ( combined drug Prednisone and butadion). In addition to a rapid, pronounced and persistent anti-inflammatory effect, the preparation also also has an uricosuric effect (contributes to the removal of uric acid salts).

Given the likelihood of re-exacerbation against the background of corticosteroid treatment and their side effects, the use of glucocorticoids is carried out under hospital.

Local cryotherapy

The use of Local Sex Attachment is also reasonable

cryotherapy

(cold treatment) simultaneously with non-steroidal anti-inflammatory drugs. Cryotherapy - short-term effects of low temperatures. It allows you to improve blood microcirculation in tissues, strengthen metabolic processes. Cryotherapy has an anti-inflammatory and painkillers. With local cryotherapy handle the struck joint ice (temperature minus 180

With gas. Staying for 2-3 minutes in

cryosauna

In the absence of conditions for cryotherapy at home, you can apply a plastic bag with ice to the sore joint.

Anesthetics

With severe pains are assigned

package preparations

The sick gout should have any anti-inflammatory and painkillers in a home first-aid kit, because the gog attack can start suddenly at any time.

Anti-dagic treatment

Prolonged anti-infraced treatment and supporting therapy in an individually selected dosage prevents the progression of the gout and contributes to the reverse development of tofus (deposits of uric acid crystals in tissues in the form of dense nodes). Nodes can soften and even disappear.

Starting taking anti-dagic drugs should only be in the intergreacy period. If the attack of gout developed against the background of the already conducted treatment, it is not necessary to cancel the drugs. When taking anti-dagrics, it is necessary to consume a daily at least 2-2.5 liters of liquid.

For proper treatments, it is necessary to determine its type (metabolic, renal or mixed).

In the metabolic type of gout develops due to excess formation of uric acid in the body. In the renal type, the disease is associated with the insufficient elimination of uricular connections by the kidneys. With a mixed type, both of these reasons take place; This type of gout proceeds the most difficult.

To determine the type of gout, the patient is assigned a special diet and a complete exception of alcohol for 7 days. On the 6th and 7th day it is necessary to collect separately urine, allocated per day. In each portion, the amount of selected uric acid is determined, as well as the average daily selection. If 600 mg and more (3.6 mmol) are derived per day - metabolic type, if 300 mg and less (1.8 mmol) is a renal type.

Antipodagratic agents are divided into 3 groups:

• uricodipressive (reduce the formation of uric acid);
• uricosuric (increase the separation of uric acid);
• mixed action (reduce education and increase the selection of uricular connections).

Under the metabolic type of gouts, urrotable agents are prescribed, and with the renal type - uricosuric means. If, according to the results of the examination, there is a normal separation of uric acid (300-600 mg or 1.8-3.6 mmol), the disease may be due to a combination of increased education and insufficient removal of ultrasonic (uric acid salts). In this case, when the urinary acid isolated, less than 450 mg (2.7 mmol) are prescribed, urronsuric agents are prescribed, and if 450 mg is allocated and more - urrodpressive means.
Urbelpressive means

The urrodpressive means include allopurinol, thiopurinol, hepatocatalase, orothic acid.

Indications for their purpose are:

• gout with the lesion of large joints and large nodes;
• gout (primary or secondary) for blood diseases;
• nephropathy (kidney disease) with increased weighing of uric acid;
• urolithiasis with ulatin stones;
• chemotherapy for blood diseases (leukemia), lymphomas, malignant neoplasms in order to prevent increased urinary acid excretion and gout manifestations.

Allopurinol - Tableted drug. Doses of Allopurinol depend on the severity of the flow of gout, the content of uric acid in the blood and the functions of the kidneys. Therefore, the dose of medication can only find a doctor. Normalization of the level of uric acid level in the blood is achieved after taking medication for 4-6 months, and a decrease in the frequency and severity of attacks, the absorption of nodes - after 6-12 months.

Alopurinol treatment is carried out for many years with minor breaks (for 2-3 weeks), because With each exacerbation of the gout, the severity of the disease is growing and the possibility of developing complications with a threat to life increases. The tolerability of the drug is good.

In the first 10 days of the beginning of treatment, allopurinol is possible manifestation of articular crises (this is due to the removal of ultrasters from tissues and their crystallization). For the prevention of their occurrence, colchicine or non-steroidal anti-inflammatory drugs are prescribed to the normalization of uric acid indicators in the blood.

Take simultaneously with allopryol, the drugs of uricosuric action should not, since they reduce the effectiveness of the first. Allopurinol is contraindicated in pregnancy and in disruption of the liver function.

Tiopurinol (also the tableted drug) has the same activity as Allopurinol, but the best to the drug patients is the best.

Hepatocatalase (The drug from the beef liver) compared with allopurinol less active, introduced intramuscularly 2-3 times a week.

Ortic acidAlso, as well as allopurinol, reduces the synthesis of uric acid and at the same time enhances its elimination, but less active means compared with Allopurinol. It is used before meals in the form of granules or in the form of tablets. The drug take 20 days, then take a break for 20 days and conduct a re-course. The tolerability of the drug is good, but the effectiveness is weak. Orothic acid lowers and cholesterol content in the blood. It is usually prescribed to the drug when alopurinol is contraindicated or with poor tolerability.

Urricauric means

Uricauric remedies reduce the inverse absorption of urates in the kidney channels and increase due to the development of urinary acid kidney.

Indications for appointment of uricosuric drugs:

• renal type of gout (in the absence of severe manifestations of gout nephropathy);
• the mixed type of gout (with daily duties of uric acid less than 450 mg or 2.7 mmol;
• almopurinol intolerance.

Doses of uricosuric means are selected by the doctor individually. When taking uricosuric drugs, it is necessary to use 2-2.5 liters of fluid per day. In addition, you need to squeeze urine by using 1 teaspoon of drinking soda every morning and alkaline mineral waters. These measures are needed to prevent assembly in kidney stones.

Urikozuric drugs include salicylates in large doses (aspirin, butadion), Anthurura, Ketazone, Bemeid (Samplecid), Flexin, Atofan, Urodan.

Application salicylate, especially in large dosages, limited due to the severity of side effects from gastrointestinal tract. In the small doses, they, on the contrary, increase the level of purine compounds in the urine and increase their blood content.

In the initial period of treatment, articular crises may develop, for preventing their occurrence, a colchicine or cololide was recommended (contains colchicine, and bemeid in 1 tablet).

It is advisable to combined the purpose of Butadion and Benemide. Bemeid is usually well tolerated, but may also have side effects on the part of the digestive organs and allergic reactions. The purpose of the Benemide is contraindicated with frequent joint crises, during pregnancy, chronic renal failure and at high levels of uric acid content in the blood (above 800 mg per day).

Allopurinol slows down the disintegration of the Behelend in the body and therefore the effect of their joint use is enhanced.

Anthouran (Sulfinpirazon) should be taken after meals, drink milk, but it also has side effects on the gastrointestinal tract. Therefore, ulcerative disease duodenal gut Or the stomach is a contraindication for its purpose. It is not prescribed for severe kidney and liver lesions.

The combined use of Anthurna and Benemide has a more pronounced effect than in their isolated assignment.

Etamide It also contributes to a decrease in the blood content of urinary acid and its removal with urine. It is assigned for 10-12 days, then a break for 5-7 days and re-receiving the drug. During the year, such treatment is carried out 3-4 times. It is transferred to the drug well.

Desurick (Benzobromaron) has a strong uricosuric effect by reducing the reverse absorption of uric acid in the renal tubules and, in addition, blocks enzymes involved in the synthesis of uric acid. The drug also contributes to the allocation of uricular compounds through the intestines. In the first days of treatment, an increase in pain in the joints may be occurred. In this case, non-steroidal anti-inflammatory drugs should be taken. The drug is well tolerated, but may be adverse reactions from the gastrointestinal tract or allergies. Benzobromaron is contraindicated in renal and liver failure.

Urodan (Pre-soluble granules) contributes to the removal of uric acid and urine peeling. The course of treatment is 30-40 days (repeated as necessary).

Ketason Enhances the selection with urine of purines and has an anti-inflammatory effect.

Improving well-being occurs after 3-4 weeks from the beginning of the reception of uricosuric drugs.

Antiprocal Mixed Action

Antipodagria mixed action is

Almaron (Combined preparation containing benzobromaron and allopurinol). The effect of the drug is twofold: reduces the synthesis of urencular compounds and increases the selection of them with urine. Such a combination of two drugs makes it possible to eliminate the formation of stones in kidney and reduce the risk of allopurinol side effects. Reception of this drug does not require compulsory abundant drinking and urine sick. Only in the presence of patients with urolithiasis, they need to consume 2.5 liters of liquids in the first 2 weeks and to cleaned urine. Alletarone reception is more effective than allopurinol monotherapy or benzobromarone. After 3-4 weeks achieved normal indicators Blood uric acid level. The duration of the course is determined by the doctor individually (3-6 months or more).

Almaron is used for any origin of gout. The drug is contraindicated in pregnancy, breastfeeding, in chronic renal failure, with individual intolerance and under 14 years of age. The drug is well tolerated, adverse reactions are rarely noted. At the beginning of treatment, pains in the joints may increase due to the consumption of uric acid salts from gage nodes (tofuses). In these cases, indomethacin or colchicine is used.

Non-traditional gout treatments

From non-traditional methods of treating gouts should be called needleflexotherapy,

fitotherapy

Spa treatment.

Igloreflexotherapy When gougries it helps to eliminate inflammatory process In the sore joint, and therefore reduces pain experienced by the patient. Under the influence of this type of treatment, the metabolism is normalized in the affected joint. But it is possible to use needleflexotherapy only outside the exacerbation of the gout.

Spa treatment It is also carried out only during the intergreacy period. In the sanatoriums uses treatment with mineral waters and mud. Radon, iodine-bromine and chloride sodium baths are prescribed (general, 4-chamber, 2-chamber). Under the action of these procedures, blood supply and nutrition of tissues in the joints improve, the work of the kidneys is improved, the separation of uric acid increases, movements in the joints improve. Souls (Charco, underwater, jet) are widely used. Physiotherapy methods are widely used, medical physical education, massage.

Patients with gout are shown by such resorts: Pyatigorsk, Tinaki (Astrakhan region), Yalta, Odessa, Evpatoria, Yangan-Tau (Bashkiria) and others. Sanctures are contraindicated in chronic renal failure and difficult to enhance blood pressure.

Phytotherapy: ethnoscience It is recommended to use for the treatment of gout rowan, lingonberries, a richness, a hunter, birch, Ivu, geranium, mint, wormwood, dandelion, yarrow, rosehip, celery. People's medicine recommends in words of grades from herbs.

Cannot be used herbal teas During the treatment of colchicine.

With an acute fit, the gouts use such a collection (1 cup of ragum every 2 hours): Calendula flowers, blue and peony cornflower - 5 g, the fruits of juniper and cortex are crazy - 5 g, black elderberry flowers and nettle leaves. , Willow bark, grass horsetail and birch leaves - for 20 g.

Favorable psycho-emotional climate In the family and at work, sufficient sleep and physical activity also contribute to normalization exchange processes in organism.

Diet therapy for gout

An exceptionally important role in the treatment of gout plays compliance

Often, a clear observance of a diet can even save a patient from gout attacks.

It is extremely important to be a complete refusal of alcohol consumption. This prerequisite must be observed in the treatment of allopurinol. If the effect of treatment is absent, it means that the patient uses alcoholic beverages.

Exclude from food Recommended Oily meat, beef, offal (lungs, liver, kidneys, brains), meat, fish and mushroom broths, white mushrooms, peas, asparagus, fatty fish, sardines and sparkling, smoked fish, herring, pork and culinary fat, cauliflower , spinach and sorrel.

Limit It is desirable: consumption of coffee, strong tea, cocoa, chocolate, products made of and puff pastry, sauces, ketchups, figs, fresh tomatoes, tomato paste and salt. The number of fats consumed should be reduced, because They reduce the separation of uric acid. Vegetable oil and creamy are allowed from fats. Non-fat varieties of meat and fish are allowed to eat in boiled and slightly fried form (1-2 times a week).

Allowed in nutrition various porridges chicken eggs (1 / day), Swiss cheese, caviar, white and black bread, milk, sour cream, kefir, cottage cheese, walnuts and forest nuts, potatoes, onions, radish, eggplants, beans. It is very useful to use berries and fruits, such as: oranges, grapes, lemon, cherry, dogwood, blueberries, apples, strawberries, plums, pears, watermelon. Fruits can be consumed fresh and in the form of compotes, kissels, hots. Lemon juice, bay leaf, vinegar, cinnamon, vanillin are allowed from seasoning.

Food should be taken fractionally, in small portions, 5-6 times a day. Alkaline mineral water, rosy rose - drink in the intervals between meals.

Patients suffering from gout are recommended to control their weight. If there is an overweight, it is desirable to apply unloading days 1-2 times a week. You can carry out fruit and vegetable (1.5 kg), kefir (1-2 l) or cottage cheese-kefir (low-fat cottage cheese 400 g and kefir 500 ml) days. Full starvation is not recommended.

Conclusion

Summing up, it should be noted that the basic principle of the treatment of gout is a long reception of funds to normalize the level of uric acid in the blood. Honey with the appeal to the doctor under the manifestation does not follow. Properly selected treatment will relieve the patient from articular crises, subject to a clear compliance with the recommendations of the doctor and the corresponding diet.

ATTENTION! The information posted on our website is a reference or popular and provided with a wide range of readers for discussion. The purpose of medicines should be carried out only by a qualified specialist, on the basis of the history of the disease and the results of diagnosis.

Gout, or gout arthritis, is a disease that affects human joints due to salt deposits. Despite the very familiar name on a hearing, sick of the gout of three people out of a thousand. In the age criterion, the disease occurs in people over 40 years of age, there are no men and women in the sexuality of separation - gout. The most common location of the disease on the human body - the fingers of the feet

Preceded the development of gouts can many factors. Among people entering the risk group - sugar diabetes and hypertension persons. The disease has an inheritance property, so it is worth considering the hereditary factor. The gout of the feet may arise due to the excessive load that the feet are experiencing. More severe arthritis of the feet are sick of elderly. In addition, unbalanced nutrition and, as a result, the disturbed metabolism in the body may affect the development of gout and aggravate it. Not only these factors will affect the fact that the medicine from gout will be most effective in treatment, but and what symptoms accompany the disease and what extent it has reached.

Symptoms for gout

The disease may not yet file any signs and manifest itself completely suddenly, while with very tangible painful phenomena. The main symptom of the originable disease is swelling and elevated temperature in the patient area. In most cases, heat and severe pain notify about themselves at night. Moreover, the joint is so sensitive to any touch that even a light sheet can cause acute pain. Subsequently, a feeling of tingling is added to a strong pain and feeling of heat in the joint.

If you ignore this symptoms and do not take any attempts of treatment, the attacks will appear increasingly, and the disease will affect all new areas of the joints. The launched stage of gout arthritis often leads to such complications in the human body as kidney disease and urinary tract.

Despite the latest technology in pharmaceutical and the effectiveness of treatment, it is impossible to fully overcome the gout, it acquires a chronic form, but to facilitate the state and slow down the development of the gout using true selected tablets.

Power treatment

The symptoms indicating the possibility of the disease must, first of all, provoke a person to the campaign to the doctor. By appointing an appropriate examination and confirming the diagnosis, doctors in accordance with the degree of disease are prescribed by the patient drugs that have a multidirectional action. Pill tablets should have a minimum, a three-component effect - the operational elimination of painful sensations, preventing possible attacks, suspension of long-term complications.

Each person neglecting the treatment regimen is responsible for his own health and life. The refusal to receive medicines leads to the destruction of the kidneys and further damage to the joints. Correct treatment, the fulfillment of all the instructions of the doctor leads not only to eliminate pain, but also to the possibility for a long time or, perhaps forget about it forever.

Drugs from gout

To date, despite the development of medicine and the latest technologies in the manufacture of medicines, there is not so many drugs used for the treatment of gout. In terms of its action, they are classified for temporary and long-term preparations. Short-term drugs allow you to quickly remove pain. With the elimination of attacks, painkillers are struggling, anti-inflammatory drugs that have not only analgesic effects, but also eliminate the focus of inflammation.

In turn, long-term drugs helps to remove not so much painful sensations as reduced the level of uric acid in the blood plasma and, as a result, slow down the development of the disease and eliminate complications.

In modern medicine, Colchicine is one of the best medicines used to combat the gout. The drug refers to the alkaloids of a tropan series and has an analgesic effect, and also neutralizes the formation of salt sediments in tissues and minimizes the migration of leukocytes in the damage zone. The drug was created on a vegetable basis, containing in its composition the main component is a non-laminate of autumn, so it can be applied not only with therapeutic, but also with a prophylactic goal.

It is well tolerated by patients, and in addition to the therapeutic effect has high health safety. Efficiency The drug largely depends on the correct reception. As soon as the disease is diagnosed, colchicine should be taken in the first day every hour. It should be borne in mind that the maximum daily dose should not exceed 10 tablets. The course of treatment with a colchicine ends when the desired result is achieved and by appointing a doctor.

As a fairly effective drug, actuating and bydrawn by the kidneys, it is contraindicated to people with renal and liver failure, as well as with individual intolerance to the components of the drug. It is worthwhile to take colchicine during pregnancy and only after the permission of the doctor. Overdose of the drug or the presence of contraindications may aggravate the condition and cause vomiting, diarrhea. The emergence of other side effects should force a person to refuse immediately from taking medication and consult a doctor. In addition, the drug should not be taken for a very long time. In this case, he may cause the threat to the development of anemia and leukopenia.

Allopurinol does not help relieve pain, but, in turn, it reduces the uric acid indicator, and also serves as a protective barrier to possible complications of gout. Treatment should be started with a minimum daily dose - 100-300 mg, which must be divided evenly during the day for 3 receptions. On the recommendation of the doctor and the absence of side effects, the dosage can be increased - up to 100 mg every two weeks. At the same time, the maximum daily dose should not exceed 800-900 mg. The therapeutic effect can be achieved with proper treatment without a passing of tablets during the first month of reception of the drug, given that the daily dose should not be less than 200-600 mg.

Patients accepting Allopurinol, each month it is necessary to test the blood test, which determines the level of uric acid. By the way, the decline in this indicator will already be noticeably in the first month of treatment.

Despite the wide effect of the drug, its application must be appointed by a physician with special care. A person should not have other concomitant diseases that may be aggravated by the reception of Allopurinol. In addition, it is contraindicated in hepatic insufficiency and during the period of a gout.

Alopurinol's analogues serve Tiopurinol, Anthourane and Hipurik.

The best of its kind is very popular and recently constructed the drug Fulflex. It is convenient because it is produced in two forms - in the form of cream and tablets - and allows you to fight the disease not only from the inside, but also outside. The drug refers to the means of short-term action and has a simultaneous, analgesic and anti-inflammatory effect. The medication includes extracts of such plants as martinium fragrant, bark willow, bark bark, horse chestnut, as well as Eucalyptus essential oils, sage and juniper, which is in many ways safe affects the human body. In addition, among its components vitamins E and PP. By the way, Martinia is fragrant is used for a long time as a means that struggling with inflammation and edema on certain areas of the body. Especially widespread use is this plant in the east.

Reception The drug is designed for a month in the calculation one tablet per day, the cream is rubbed twice a day. Fulflex is contraindicated in pregnant and lactating women.

Voltaren

Temporary stopping of seizures of gouty arthritis is possible with the help of the actual type. The effect is achieved by simultaneously receiving tablets and ointment of this drug. To achieve an explicit result, it is recommended to take the maximum dose of 200 mg on the first day, subsequently - 150 mg in the knocks, as well as twice with a sick joint with cream.

Such an action has ibuprofen and diclofenac, which remove inflammation, allow you to remove the swelling and pain, and also reduce the temperature. The same scheme adheres to naproxen. All these means are strictly contraindicated during pregnancy.

The effectiveness of treatment, up to the elimination of all sorts of attacks subsequently, largely depends not only on compliance with dosage norms, but also on duration. It will be extremely inappropriate to stop drug therapy in the disappearance of symptoms and confidence that the disease has retreated. Even when the pain is stopped, the drug should continue to accept until the end of the course. Compliance with the deadlines, the lack of independent treatment without observation by the doctor will allow enough to fight the gout, forgetting about the pain forever.