What is prescribed xanthinol nicotinate: instructions for the use of tablets and injections. Xanthinol nicotine - vasodilator in the complex therapy of osteochondrosis for what makes xanthinol nicotin

What is prescribed xanthinol nicotinate: instructions for the use of tablets and injections. Xanthinol nicotine - vasodilator in the complex therapy of osteochondrosis for what makes xanthinol nicotin

23.07.2020 Insulin

Vasodinating medicines in medical practice are represented by a group of tablets, capsules, solutions. The instruction on the use of xanthinol nicotine will help properly take the drug and secure yourself from unwanted consequences.

Ksantinol Nikotinat: Therapeutic action

The drug xanthinol nicotine is a vasodilator

Ksantinol Nikotinat - medicine, provides first aid to vessels. Refers to an extensive group of vasodilatory drugs. It is used in medicine for treatment and diseases of vessels: heart, brain, lower and upper limbs, spine.

The preparation contains two components: nicotinic acid and theophylline.

Nicotine Acid - Vitamin B3. It helps with impaired metabolism, participates in protein exchange. Expands vessels, stimulates work gastrointestinal tract. a lack of nicotinic acid Worsen state nervous system, causes irritation of mucous membranes and skin cover. In the patient's body, the level is violated.

Theophylline - stimulates the nervous system, reduces myocardium, has a bronchoranty effect. Expands coronary vessels. Is a diuretic.

The main element of the drug - xanthinol nicotinate. Each ampoule or tablet contains 150 mg of this substance. In addition to it, the composition includes: milk sugar, calcium stearate, corn starch and poveidone, like enterosorbent.

The drug has a vasodilatory and anti-kleotic effect. Reduces the likelihood of blood clots.

Xanthinol nicotine repeats the composition of nicotinic acid. Acts as medicines applied in treatment respiratory diseases. Easily dissolved in distilled water, poorly - in alcohol.

Medical properties:

Improves the blood circulation of the brain
Expands vessels
Enrich the organism oxygen
Lipid lowers
Prevents development
Dissolves blood clots, blood clots
Accelerates blood circulation in the field of myocardium

Xanthing is nicotine instantly absorbed in the digestive tract. After some time, transformed into nicotine acid and theophylline. Excreted from the body with urine. For intramuscular injections Improvement is observed after 10 minutes.

Watch Vitamin B3 video:

Application

Xanthinol nicotine applied in atherosclerosis of vessels

Xanthinola Nicotinat is used in many industries. Apply with pathologies, diseases and conditions:

reino disease
menieral syndrome
burger Disease
atherosclerosis of vessels
migraine
proleside
dermatosis
arterial
acute
fetal asphyxia postpartum and intrauterine
trophic ulcers foot
pathology of blood vessels
purulent wounds

The duration of treatment depends on the disease. It is 5 - 10 days.

Method of reception

Since the medicine is produced in different forms, then the methods of receiving three: in Vienna, intramuscularly and orally.

Tablets are prescribed by adults. Take after eating, entirely. Assign on a tablet 3 times a day. On the recommendation of the doctor, the dose gradually increases to 3 tablets three times a day. Treatment lasts one and a half - two months.

Crosses in Vienna are made in the morning and in the evening of 2 ml. The patient is at this time lies.

Intramuscular injections put from 2 to 6 ml per day for two weeks.

If the patient suffers a strong circulatory disorder, then pills and injections are prescribed.

Ophthalmologists are treated with a solution of the drug. Use 300 mg for medicinal electrophoresis on the procedure. Ionophorez make 20 days.

Contraindications

Cannot be taking xanthinol nicotine at hypotension

Prank ulcer
Migraine
Glaucoma
The presence of bleeding
Disease of kidneys
Mitral
Pregnancy, first trimester
Childhood
Breast-feeding
Postoperative period
Allergy to the composition of the medicine
Individual intolerance

Side effects

The side effect of the use of xanthing nicotine can be chest pain on the left

Xanthing is nicotinatte affects human condition. Approach nausea, weakness. Feels feels, blushing the skin of the face, neck and head.

The appetite disappears, the work of the stomach is upset. All signs disappear 15-20 minutes after taking medication. Do not stop treated.

The body's system react to the side effect:

Nervous system - arises sharply headache, the head is spinning, sometimes nauseous. Symptoms disappear after 10 minutes.
Cardiovascular system - reduced pressure, appears. Violated heart rhythm.
Endocrine system - if the drug is accepted for long and large doses, the body reduces glucose tolerance.
The digestive tract is a stomach and diarrhea disorder, nausea and weakness. The amount of liver transamamine in the patient's blood increases.
The respiratory system - sometimes the patient feels a shortage of air, bothering shortness of breath.

Often, when taking xanthitinol, the nicotinate appears rashes on the skin, itching, burning. Increases blood flow to face and neck, why they blush. Sometimes there is a swelling of Qink. The content of uric acid in the blood increases.

When the appearance and strengthening of side symptoms, it is recommended to urgently consult a doctor. If unwanted effects do not pass, stop the treatment.

Overdose

Acute abdominal pains may indicate an overdose of xanthinol nicotinate

Xanthinol Nikotinat is considered to be neyold, he rarely cause poisoning. However, when taking large doses for a long time, the level of liver enzymes exceeds the norm. Urinary acid accumulates in the blood, and the body loses the ability to transfer glucose.

With an excess of the drug in the body, in the patient, acute abdominal pain appear, diarrhea, weakness. In the event of these symptoms, doctors prescribe a hypertime therapeutic treatment.

Compatible with alcohol

With attention should be treated with alcohol. The effectiveness of the treatment and effect of the drug is influenced by wine, beer, vodka, champagne and other sturdy drinks.

The adoption of the alcohol per day before taking medicines to men, and for a month and a half - women. After taking medication to drink alcohol, you can women in 20 hours, men - after 14.

If there are symptoms of alcohol alcohol incompatibility, stop treated, drink more water, consult a doctor for advice.

Medicinal interaction

It is undesirable to simultaneously use xanthinol nicotine and heparin

To avoid lowering pressure, it is impossible to take xanthinol nicotinate simultaneously with hypotensive drugs. It is also undesirable to receive simultaneously with stanchantin, antidepressants, heparin, fibrinolysin.

During injections, it is forbidden to mix in a syringe with other solutions.

Analogs

All drugs have analogues. They are identical medical properties. Synonyms call medications with the same main substance in the composition.

The most famous analogues:

Tever
TEODIBAVERIN
Theobromine
Teminal

Synonyms are:

Angioamine
Meghemin
Vedern
Xavin
Sadamin
Complim
Theronicic
Complamex
VINKANOR.

Appointments or synonyms for medicines should a doctor.

Important instructions

With the simultaneous reception of the drug xanthinol, nicotine and heart preparations are necessary to periodically make ECG

Prevent water or alcohol solution In the eyes and on the mucous membranes.
With simultaneous reception of cardiac drugs, a doctor's inspection is necessary. Be sure to do.
Carefully apply patients with reduced blood pressure. It is possible to reduce pressure, development.
During pregnancy, Xanthing is not desirable nicotane. Sometimes the doctor appoints it in the second, third trimester, in exceptional cases, and under control.
People with renal or liver failure, the drug is prescribed in small doses. Then increase.
Often receiving tablets, injections causes weakness, dizziness, decreased blood pressure. Therefore, when receiving, refuse to control the machine and other transport. It is impossible to work on the conveyors.
Under the control of doctors, take the drug with atherosclerosis, violation of the heart and elderly.
Diabetes need to check blood glucose testimony, more often to take analysis.
With prolonged treatment with high doses, it is changed, the drug should be discontinued.
It is forbidden to use xanthinol nicotine with strong coffee, alcohol.

Released only on the recipe. Store medicine in a dark place at a temperature of 25 ° C. Shelf life - three years. Do not give to children!

Xanthing is nicotine - the necessary medicine, the value of which is the properties of the main actors.

When there are not enough different trace elements in the body - this is necessarily affected by health and general condition. Fatigue, excessive fatigue, bad Son. And anxiety is talking about the need to consult a doctor.

Maybe the first symptoms are manifested serious diseases, such as hypertension and atherosclerosis of vessels, in the absence of the treatment of which the heart attack and stroke can be involved.

Normalize pressure and increase vitality, as well as cope with many diseases of the cardiovascular system, such a drug is capable of as xanthinol nicotine.

What is the medicine, in what cases is used and what kind of contraindications it has, learn later.

Instructions for use

Xanthing is nicotine is a complex drug, which includes nicotinic acid and theophylline. These two trace element are capable of performing such functions in the body as:

With long-term systematic drug intake, it is able to reduce cholesterol in the blood, by splitting atherogenic lipids in vessels.

Blood viscosity is reduced, therefore the risk of thrombocytosis ( elevated level blood platelets), thrombosis, thrombophlebitis and embolism are reduced several times.

Indications for use

Xanthinol Nikotinat is used in the treatment of the following diseases:

bleeding open wounds of limbs that do not heal for a long time (when sugar diabetes or tuberculosis of the skin);
thrombophlebitis, as well as the embolism of the limbs;
inflammatory processes in veins (thrombohangiite);
sealing of body tissues (sclerodermia);
breeding violations of the brain;
eliminate the effects of infarction and strokes;
atherosclerosis of coronary vessels;
hypercholesterolemia;
dermatosis of various etiology.

In some cases, the drug can be used to treat raino disease, for which the violation of the capillary blood flow of the limbs is characterized, as a result of which the phalange of the fingers acquire a whiten or a blue shade.

Method

Oral reception involves the use of the drug 300-600 mg, 3 times a day. Tablets do not chew, but quickly swallow, drinking with a small amount of water.

The best thing tablets drink after eatingAs they are able to destroy the mucous membrane of the stomach, if it is empty.

Injection solutions are injected:

intravenously - very slowly, the patient is in the position lying on the back, 300-400 mg, 2-3 times a day;
intramuscularly - 300-500 mg, 2-3 times a day;
drip - 150-500 mg per one reception, which is carried out once a day.

In the treatment of acute cardiovascular diseases, a combined reception of the drug is possible, which will enhance the therapeutic effect several times.

However, the maximum allowable daily dose should not exceed 900 mg in the amount.

Composition and form of release

Xanthinol nicotine produced in two forms:

Tablets are packed in packs of 30, 60 and 120 pieces. Dosage in one tablet of the main operating component - 300 and 600 mg.
The injection solution is produced by 2 and 5 ml in glass ampoules. Cardboard boxes contain 5 or 10 ampoules.

The auxiliary components in tablets that improve and retain the effectiveness of the main substance are: corn starch, poverant.

In injection solutions with such auxiliary component is an aqueous solution.

Medicinal interaction

By virtue of the ability of the drug to provide a powerful hypotensive effect on the body, it is not recommended simultaneous use with other drugs that reduce pressure.

Otherwise, bradycardia develops, and the person is in a fainted state.

Xanthinol nicotine is able to increase the effect of stanfantine, which leads to the formation of a toxic hard-soluble sediment. Therefore, their simultaneous use in therapy is unacceptable.

Side effects

a sharp decline arterial pressurefor which the loss of consciousness is characterized, the noise in the ears, weakness, cold in the limbs;
redness of the skin;
tightening diarrhea with blood impurities;
lack of appetite;
pain in the epigastric part of the abdomen;
an increase in uric acid;
violation of glucose tolerance.

In extremely rare cases, when a patient has increased sensitivity to nicotine acid, an allergic reaction can develop, the manifestations of which are expressed in such symptoms as:

angioedema edema;
strong itch skin cover, especially soles and palms;
euction of mucous membranes, including an increase in language volumes;
anaphylaxis, accompanied by the absence of pulse and breathing.

Contraindications

The drug has some contraindications, so it is not necessary to use it for therapeutic purposes. The following categories of patients fall into the risk group:

cirrhosis of the liver;
renal failure;
bloodfaction of the gastrointestinal tract: stomach ulcer and duodenal gut;
congenital hypotension.

Reception of medicines are made exclusively under the control of the doctor in a medical institution.

During pregnancy

Since xanthinol nicotine penetrates well into the blood and is able to almost completely bind to blood proteins, receiving it during pregnancy is contraindicated. This is determined by the high risk of developing pathologies that are associated with a violation of the functionality of the cardiovascular system.

Terms and Storage Terms

Tablets are stored in the original packaging, at a temperature of no more than 25 ° C. Shelf life - 3 years.

Shelf life is 1 year, after which the drug is not used in therapy.

Price

The average price in Russia to the drug in tablets is - 200-250 rubles, ampoules - 180-320 rubles per pack.

In Ukrainian pharmacies, the tablets will cost 115-130 UAH, and ampoules at 85-100 UAH per pack of 5 pieces.

Analogs

Medications that have such a hypotensive effect on the body, consider:

Cardioeis;
Atherofiton;

Xanthing is nicotinat - a medicine that expands the vessels and improves blood circulation in the brain. The effect of the drug enhances the heart rate and improves the process of metabolism in brain tissues. A remedy for injection solution is available. Before applying the drug, it is necessary to explore the instructions, familiarize yourself with side effects and contraindications.

Doctors can prescribe xanthinol nicotine to treat such diseases:

Atherosclerosis in the patient vessels;
Reino disease;
Manifestation of diabetic angiopathy;
Treatment of retinopathy;
Signs of thrombophlebitis;
Therapy of thrombosis of any gravity;
Frequent migraines;
Brain circulation problems;
Period after the operation on the brain;
Treatment of Meniere's disease;
The appearance of ulcers on the legs;
Problems with vessels in the eyeball;
The process of retinal detachment in the eye.

Contraindications

In some cases, the injections of xanthinol nicotine will be dangerous to health. In the instructions for use, such contraindications are highlighted:

Patient allergies on active ingredients in the composition;
Problems with the work of the heart;
After infarction state;
Problems with the work of the kidneys and liver;
Stagnant heart failure;
Strong bleeding;
Ulcers in the stomach;
Signs of glaucoma;
At the time of mitral.

With such violations, the use of drug is strictly prohibited. Therefore, before treatment, it is necessary to undergo a survey and find out the exact diagnosis.

How to apply the drug

Doctors prescribe xanthinol injections by nicotine intravenous or intramuscular administration method. The drug helps perfectly with strong circulatory disorders.

The remedy must be introduced slowly intravenous by the doctor's supervision. Dosage for therapy - 2 ml twice a day. After that, you can move to the introduction of the drug intramuscularly. 2 ml of medication is prescribed 3 times a day. For a better result of treatment, the doctor may assign a parallel reception of the nicotine xanthinol in the form of tablets. Usually you need to take 2 tablets three times a day.

If a patient has a severe stage of the disease, then the doctor prescribes the drug intravenously drip method. In this case, the dosage is compiled 10 ml. The introduction of the drug lasts 3-4 hours depending on the patient's condition. In severe cases, it is necessary to carry out injections 4 times a day.

The course of therapy is exhibited by a doctor individually depending on the stage of the disease. Usually long-term treatment does not exceed 21 days.

If blood supply is broken in the patient tissues, then the doctor is prescribed to 2 ml dosage three times a day. Gradually, the amount of the drug increases to 6 ml. Important at the time of therapy follow the state of health and life indicators. The course of treatment lasts 3 weeks.

Often ophthalmologists use xanthinol nicotinate for comprehensive treatment. The drug is used by ionophoresis. Optimal dose - 300 mg drug per day. The first procedure should last no more than 15 minutes. Gradually, the duration of each procedure increases and at the end comes to half an hour. The course of therapy is 20 days.

Remember that individual dosage and drug administration method will be assigned to each case. It is necessary that at the time of injection the patient was under the supervision of the attending physician.

Overdose drug

In case of administration of too much dose, the patient may begin complications:

A strong attack of tachycardia;
Feeling heat on the body;
The skin begins to blush and lick slightly;
Compression appears in the head;
The patient becomes weak and sluggish;
A faint condition may begin;
Approach nausea with subsequent vomiting;
The emergence of diarrhea.

If the patient is injected into the patient too quickly, it can begin such complications:

Dizziness attack;
A feeling of suffocation;
Severe pain in the heart;
Manifestation of arterial hypotension.

At the first signs of an overdose you need to immediately consult a doctor. The specialist will prescribe symptomatic therapy and will carry out control over the patient until negative symptoms go through.

Side reactions to the drug

In the injections of xanthinol, the nicotine in the body can begin adverse reactions. Usually they occur with the intolerance to the composition of the drug or with an overestimated dosage for the patient.

Where do you occur?	Side effects
IN immune system such adverse reactions appear	Allergic manifestation; Rash on the skin; Hives; Itching; The feeling of chill; Fever attacks; Strong heat; Tingling the whole body; Manifestation of angioedema edema.
Such complications arise in the nervous system	Bouts of headaches; The patient often gets tired and feels weakness; Begins to spin the head; Frequent insomnia.
Side effects appear in digestion	Nausea attack; Manifestation of diarrhea; Vomit urge; Attacks of anorexia; The belly begins to swell; Pain and discomfort in the stomach appears; An ulcer arises; Attack of gastralgia; Increase liver enzymes.
In the heart system you can allocate such complications	Attacks of arterial hypotension; Frequent tachycardia; The emergence of angina; Problems with heart rhythm; Obtaining syndrome in easy degree.
IN bone system There are such side effects.	Convulsions in muscles; Feeling of weakness; The emergence of arthritis; Manifestation of gout.
IN spectator Such complications may begin.	Falling the definition of vision; Eye apples swell; Arises exophthalm; Manifestation of spotted edema; The emergence of amblyopia.
Other adverse reactions	Sensation of itching at the injection site; The emergence of hyperuricemia; The patient feels a shortage in the air; The skin begins to peel; Hyperkeratosis occurs.

Each tool has its own instructions for use with which you must read. Use a new medicine without appointing a doctor is prohibited.

1 tablet contains 150 mg active component xanthinola nicotine.

1 ml injection solution contains 150 mg of active ingredients ksantinol Nikotinata as well as injection water.

Form release

The medication is produced as a solution, in tablet dosage form.

pharmachologic effect

Vasodilator.

Pharmacodynamics and pharmacokinetics

The drug has the properties and medicines of the group theophylline: Improves collateral blood circulation , expands the lumen of peripheral vessels, has pronounced antiagregant effect , enhances the process of synthesizing ATP and oxidative phosphorylation.

The principle of impact is based on the substrate stimulation of the synthesis of over-phosphate and over, on increasing the intracellular content of the CAMF, on blocking phosphodiesterase and adenosine receptors.

Xanthinol nicotine improves nutrition of tissues, their oxygenation, microcirculation . For long use There is an increase in the activity of lipoproteinlipase, the concentration is reduced. atherogenic lipids and, fibrinolysis processes are activated, marked anti-theterosclerotic effect The aggregation is reduced, the blood viscosity decreases.

The medication reduces the severity of the consequences of cerebral hypoxia, strengthens brain circulation , Promotes an increase in the IOC, enhances the reduction of myocardial, reduces the OPS.

For drug It is characteristic of Nicotine-like syndrome, which manifests the exacerbation of the sensitivity of taste and olfactory sensations due to the hyperesthesia of the mucous membranes of the oral and nasal cavities.

Indications for use

Xanthinol nicotine is prescribed during Rhino's disease, diseases of Burger (refriring Trombangiit), with obliterate limb vessels, during retinopathy, menieral syndrome , in migraine, breakdown, trophic shin ulcers, when post-terromboflectric syndrome , with acute (with the defeat of surface or deep veins), with diabetic angiopathy, cerebrovascular failure, with scleroded bread, sclerodermia, violation of cerebral blood circulation, during atherosclerosis of the brain vessels, hypertriglisseridemi , hypercholesterolemia, atherosclerosis coronary arteries, with postpartum and intrauterine asphyxia of the fetus, with dermatosis Against the background of disturbed trophy of vascular genesis.

Contraindications

Xanthinol nicotine is not prescribed with pronounced pathology of the renal system, during pregnancy, arterial hypotension , ulcerative disease of the digestive tract in the aggravation stage, in mitral stenosis, intolerance to the active substance, acute bleeding , decompensated form of HSN, with acute heart failure, with acute.

Side effects

Instructions for the use of nicotine xanthinol indicates the following possible side effects: heat, drop blood pressure drop, gastralgy , decline in appetite, diarrhea, nausea, weakness, skin hyperemia.

Instructions for the use of nicotine xanthinol (method and dosage)

Medicine is used intramuscularly, intravenously (drip, inkjino) either inward.

Instructions for tablets

Tablets are recommended to swallow entirely. Reception scheme: Three times a day of 150 mg. In some cases, the amount of medicine is increased to 300-600 mg (one-time reception). With a positive dynamics, the dosage is gradually reduced. The duration of therapy is at least two months.

Solution xanthinol nicotine, instructions for use

Intramuscular The drug is administered as a 15% solution of 2-6 ml within 2-3 weeks.

Intravenously The drug is poured in a stream 1-2 times a day in 2 ml in the form of a 15% solution (the patient should lie on the couch at the time of the procedure). The duration of treatment is 5-10 days. Intravenous drip injections are carried out at a speed of 40-50 drops / minute. Pre-10 ml of 15% of the drug is bred in sodium chloride solution (0.9% 200 ml) or in a declaration solution (5% 200-500 ml).

When diagnosing acute violations of the blood supply to tissues, in addition to parenteral administration at the same time, a medication is prescribed in a tableted dosage form three times per day of 300 mg.

Overdose

The use of nicotine xanthinol in large dosages for a long time leads to hyperuricemia , increase the level of liver enzymes, change to glucose tolerance. In overdose marks vomiting, epigastric pain , drop blood pressure.

Interaction

Xanthinol nicotinate can not be applied with inhibitors of MAO . With extreme caution, the medication is prescribed with simultaneous therapy (there is a sharp increase in the effect), hypotensive drugs (sympatholites, alpha adrenoblocators , alkaloids of ardines, beta-adrenoblays, gangliblocators).

Terms of sale

Requires a recipe.

Storage conditions

In a dark, inaccessible place at a temperature of 15-25 degrees Celsius.

Shelf life

Not more than three years.

special instructions

It is unacceptable to the appointment of the drug xanthinol nicotine in the first trimester. In the second and third trimester, the drug is used under the condition of careful observation of the patient.

The purpose of the medication in large quantities causes dizziness and a drop drop.

It is necessary to avoid entering the drug on the mucous membranes, in the eye.

Analogs of Ksantinol Nikotina

Coincidences on the ATX 4 level code:

Does not have structural analogues.

Dosage form: & nbspr acasor for intravenous and intramuscular administration Structure:

1 ml of the drug contains:

active substance: xanthinola nicotine - 150.0 mg;

ancillary: Water for injection - up to 1.0 ml.

Description: P right, colorless solution. Pharmacotherapeutic Group:Vasodilator ATH: & NBSP

C.04.a.d.02 Ksantinol Nikotinat

Pharmacodynamics:

Xanthinol nicotine combines the properties of the drugs of the Teophylline and Nicotinic acid group: it has an antiagregative effect, the peripheral vessels expands, improves collateral blood circulation. By blocking adenosine receptors and phosphodiesterase, increases the content of cyclic adenosine monophosphate in the cell, the substrate stimulates the synthesis of nicotineidadenindinucleotide (above) and nicotineidadenindinucleotide phosphate (it is necessary). Improves microcirculation, oxygenation and nutrition of tissues. With prolonged use, anti-studosclerotic action has, activates the processes of fibrinolysis, reduces the concentration of cholesterol and atherogenic lipids, enhances the activity of lipoproteinlipase, reduces blood viscosity, reduces platelet aggregation.

Reducing the overall peripheral vascular resistance, contributes to an increase in the minute volume of blood and the increase in cerebral circulation, reduces the severity of the effects of cerebral hypoxia.

Pharmacokinetics:

Pharmacokinetics xanthinol nicotine poorly studied. After intramuscular administration is absorbed quickly and fully. With repeated use of the drug, its pharmacokinetics does not change. Medication cumulation is not marked.

After administration is subjected to intense metabolism in the liver. In patients with impaired liver and kidney function, a slowdown in the elimination of xanthinol nicotine and an increase in its bioavailability is noted. A similar situation occurs in older persons (over the age of 60), compared with young patients. Indications:

As part complex therapy: Supported atherosclerosis of limb vessels, Reino disease, obloring endarterite, diabetic angiopathy, acute thrombophlebitis (surface and deep veins), trophic ulcers of the heads, cerebrovascular insufficiency, atherosclerosis of the brain vessels, violation of cerebral circulation, atherosclerosis of coronary arteries, hypercholesterolemia, hyperitriglyceridemia.

Contraindications:

Increased sensitivity to xanthinol nicotine or any other component of the drug, acute heart failure or decompensated chronic heart failure, acute bleeding, acute myocardial infarction, mitral stenosis, ulcerative disease Stomach and 12-rosewood in the exacerbation phase, arterial hypotension, pregnancy (especially in the first trimester), lactation period, acute renal failure, glaucoma, unstable angina.

Children's age (absent experience).

Pregnancy and lactation:

Do not apply in the I trimester of pregnancy. In the second and third trimester of pregnancy, the use of the drug is permissible only in the presence of absolute testimony in case the estimated benefit for the mother exceeds the potential risk to the fetus. The use of the drug in this case should be carried out under the careful observation of the doctor.

If necessary, take the drug during lactation it is necessary to interrupt breast-feedingbecause stands out in breast milk.

Method of use and dose:

Intravenously (inkid or drip), intramuscularly.

The severity of the disease, the condition of the patient and the path of administration of the drug is estimated by the doctor.

With intramuscular administration - 2-6 ml of 15% solution daily for 2-3 weeks.

The drug is injected intravenously in a slower 300 mg (2 ml of the drug) 1-2 times a day (the patient should be in horizontal position). The duration of treatment is 5-10 days.

With acute peripheral and brain circulation disorders, the drug is administered intravenously drip at a speed of 40 - 50 drops per minute. For this, 1500 mg (10 ml) of the drug is bred in 200-500 ml of a 5% solution of dextrose or 200 ml of isotonic sodium sodium solution, the resulting infusion mixture is injected drip within 1.5-4 hours. Infusion can be repeated up to 4 times a day; The duration of treatment is 5 - 10 days.

Patients with an implanted rhythm driver are prescribed at a lower dose.

Side effects:

From the cardiovascular system: It is possible to reduce blood pressure, dizziness, heat feeling, redness of the skin.

From side digestive system : nausea, diarrhea, anorexia, gastralgy, abdominal pain, pain in epigastria,

From the nervous system: headache.

Allergic reactions : skin itch, urticaria, angioedema swelling, anaphylactic shock.

Others: Weakness, chills, tingling skin cover, especially in the head and neck. These symptoms usually disappear after 10-20 minutes, do not require special treatment and refusal to use this drug.

When using nicotinic acid drugs can be marked false increase Catecholamin concentrations in blood plasma and urine, as well as a false-positive result of the determination of glucose in the urine using Benedict sample.

With long-term assignment in high doses, the drug causes a change in glucose tolerance, an increase in the activity of "liver" transaminase (ACT, ALT) in serum, an increase in the activity of alkaline phosphatase in serum, increasing the content of uric acid in the blood serum.

With the appearance of undesirable effects not described in this instruction, and the strengthening of the above side Effects For therapy with this drug, it should be immediately informed about this attending physician.

Overdose:

The drug is small toxic. Acute overdose of xanthinol nicotine accompanied by arterial hypotension, total weakness, dizziness, tachycardia, abdominal pains and vomiting.

When symptoms appear, symptomatic therapy is prescribed.

Interaction:

In order to avoid a sharp decrease in blood pressure, the drug cannot be used simultaneously with hypotensive drugs, including (beta-adrenoblockers, alpha adrenobloclars, gangliplockers).

Do not apply simultaneously with monoaminoxidase inhibitors and stanfantine.

The simultaneous use of nicotine acid preparations in combination with the GMG-CoA reductase inhibitors (statins) may increase the risk of developing myopathy and rhabdomyolysis.

Simultaneous use of alcohol can increase severity side effect xanthinol nicotine (sensation of heat, redness of the skin).

Special instructions:

In the second and third trimester of pregnancy and during the lactation period, the use of the drug is permissible only if there are absolute indications and careful observation of the doctor.

Xanthinol nicotine causes a "nicotine-like" syndrome, accompanied by hyperesthesia of the mucous membrane of the nasal cavity and the mouth (exacerbates the sensitivity of the olfactory and taste receptors). In connection with this smell and taste of accepted during therapy alcoholic beverages Perceived more sharp and perversions.

In diabetes, it is necessary to carefully control the glycemia.

Avoid getting the drug into the eyes or on the mucous membranes. Impact on the ability to control the transc. cf. And Meh.:

Large doses of the drug can cause dizziness, weakness and arterial hypotension, in connection with this should refrain from the management vehicle, working with mechanisms and classes other potentially hazardous species Activities requiring increased concentration of attention and speed of psychomotor reactions.

Release form / Dosage:

Solution for intravenous and intramuscular administration, 150 mg / ml.

Packaging:

2 ml in ampoules of neutral colorless glass.

5 ampoules in the contour cellular packaging from the film of polyvinyl chloride (PVC) or polyethylene terephthalate film (PET).

1 or 2 contour cellular packages along with the instructions for use and scarifier ampulos in a pack of cardboard.

5 or 10 ampoules along with the instructions for use and scarifier ampumen in a pack of cardboard with a corrugated liner.

When using an ampoules with a point or ring of a slam of a scarifier, the ampulle does not invest.

Packaging for hospitals

4, 5 or 10 contour cellular packages together with the instructions for use in an amount equal to the number of contour cellular packages, in a pack of cardboard.

At 50, 100 contour cellular packages along with the instructions for use in an amount equal to the number of contour cellular packages, in a box of corrugated cardboard.

Storage conditions:

Store in the light-protected place at a temperature not higher than 25 ° C.

Keep out of the reach of children.