This article allows you to familiarize yourself with the instructions for use. medicinal preparation Chloroprietic. The reviews of the site visitors - consumers of this medicine are presented, as well as the opinions of doctors of specialists in the use of chlorprichient in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effectsmay not be stated by the manufacturer in annotations. Analogues of the neuroleptic chlorprotine in the presence of available structural analogues. Use for the treatment of schizophrenia, neurosis and depression in adults, children, as well as in pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Chloroprietic - Antipsychotic effect is associated with its blocking effect on dopamine receptors. The blockade of these receptors also associated with anti-metic and analgesic properties of the drug. Chlorprotine is capable of blocking 5-HT2 - receptors, alpha1 - adrenoreceptors, as well as H1 - histamine receptors, which are determined by its adrenoblocking hypotensive and antihistamine properties.

Structure

Chlorprotine hydrochloride + excipients.

Pharmacokinetics

The bioavailability of chlorprotine during oral administration is about 12%. Chlorprotine is quickly absorbed from the intestine. Chlorproticisen penetrates a placental barrier and stands out in small quantities breast milk. Metabolites do not have neuroleptic activity, stand out with feces and urine.

Indications

Chlorproticis is a sedative neuroleptic with wide spectrum Indications in which include:

• psychosis, including schizophrenia and maniacal states, flowing with psychomotor excitation, arrangement and anxiety;
• "Thymelle" abstinence syndrome with alcoholism and drug addiction;
• hyperactivity, irritability, excitation, confusion of consciousness in elderly patients;
• violation of behavior in children;
• depressive states, neurosis, psychosomatic disorders;
• insomnia;
• pain (in combination with analgesics).

Forms of release

Tablets covered with a shell of 15 mg and 50 mg.

Instructions for use and dosage

Psychoses, including schizophrenia and manic states

Treatment starts from 50-100 mg per day, gradually increasing the dose until the optimal effect is achieved, usually up to 300 mg per day. In some cases, the dose can be increased to 1200 mg per day. Supporting dose is usually 100-200 mg per day. The daily dose of chlorproticsena is usually divided into 2-3 receptions, given the pronounced sedative effect of chlorproticisy, it is recommended to prescribe a smaller part of the daily dose during the daytime, and most of the evening.

Thumpling abstinence syndrome with alcoholism and drug addiction

The daily dose, divided by 2-3 reception, is 500 mg. The course of treatment usually lasts 7 days. After the disappearance of manifestations of abstinence, the dose is gradually decreasing. Supporting dose of 15-45 mg per day allows you to stabilize the state, reduces the risk of developing the next binge.

Depressive states, neurosis, psychosomatic disorders

Chlorprotine can be used in depressions, especially combined with anxiety, voltage, as an addition to antidepressants or independent therapy. Chlorproticsene can be prescribed for neurosis and psychosomatic disorders accompanied by anxiety and depressive disorders up to 90 mg per day. The daily dose is usually divided into 2-3 receptions. Since the intake of chlorproticsena does not cause the development of addiction or drug addiction It can be applied for a long time.

Insomnia

15 - 30 mg in the evening 1 hour before sleep.

Pain

The ability of chlorprotine can potentiate the effect of analgesics can be used in the treatment of patients with pain. In these cases, chlorproticsene is prescribed together with analgesics in doses from 15 to 300 mg.

Side effect

• psychomotor braking;
• low-expanded extrapyramidal syndrome;
• increased fatigue;
• dizziness;
• paradoxical amplification of anxiety, especially in patients with mania or schizophrenia;
• cholestatic jaundice;
• tachycardia;
• changes to ECG;
• ortostatic hypotension;
• clouding the cornea and lens with violation;
• agranulocytosis, leukocytosis, leukopenia;
• hemolytic anemia;
• frequent tides;
• amenorrhea;
• galactere;
• gynecomastia;
• weakening potency and libido;
• strengthening;
• violation carbohydrate exchange;
• an increase in appetite with an increase in body weight;
• photosensibilization;
• photodermatitis;
• dry mouth;
• constipation;
• accommodation violations;
• dysuria.

Contraindications

• oppression of the central nervous system of any origin (incl. caused by alcohol, barbiturates or opiates);
• comatous states;
• vascular collapse;
• blood formation organs;
• feochromocytoma;
• increased sensitivity to the components of the drug.

Application in pregnancy and breastfeeding

Chlorproticsene should not, if possible, apply to pregnant women and in the period breastfeeding.

Application in elderly patients

In the elderly patients, in the presence of hyperactivity, irritability, excitement, 15-90 mg per day is prescribed. The daily dose is usually divided into 3 receptions.

Application in children

In children, for the correction of violations of the behavior, chlorproticsene is prescribed at the rate of 0.5-2 mg / kg body weight.

special instructions

Chloroprietary should be appointed with patients suffering from epilepsy, Parkinsonism, with expressed atherosclerosis of the brain vessels, with a tendency to collaps, with pronounced cardiovascular and respiratory failure, with severe violations of liver and kidney function, diabetes, prostate hypertrophy.

The use of chlorproticsena can lead to a false positive result when conducting an immunobiological urine test for pregnancy, false increase The level of bilirubin in the blood, the change in the Qt interval on the electrocardiogram.

Impact on the ability to driving vehicles and control mechanisms

Reception chlorproticsena renders bad influence on activities requiring high speed of mental and physical reactions (for example, management vehicles, maintenance of cars, work at height, etc.).

Medicinal interaction

The inhibitory effect of chlorprotine on the central nervous system may increase with ethanol (alcohol) and ethanol-containing drugs, anesthetics, opioid analgesics, sedative, sleeping bags, neuroleptics.

The anticholinergic effect of chlorprotic is intensified by simultaneously use of anticholinergic, antgistamine and anti-parkinsonic drugs.

The drug enhances the effect of antihypertensive agents.

The simultaneous use of chlorprichient and adrenaline can lead to arterial hypotension and tachycardia.

The use of chlorproticisen leads to a decrease in the threshold of convulsive activity, which requires additional correction of the dose of anti-epileptic drugs in patients with epilepsy.

The ability of chlorprotic is to block dopamine receptors reduces the effectiveness of Leveodop.

An extrapyramidal disorders are possible with the simultaneous use of phenothiazines, methoclopramide, haloperidol, reserpine.

Analogs of the drug chlorprotine

Structural analogues of PO active substance:

• Trucasal;
• Chlorprotine 15 treatments;
• Chlorprotine 50 treaty.

Analogs of PO pharmacological group (Neuroleptics):

• Azleptin;
• Aminazine;
• Arhipiprazole;
• Barneal;
• Betamax;
• Victael;
• Galoveer;
• Haloperidol;
• Hedonin;
• Droperidol;
• Zalast;
• ZELDOKS;
• Zylaxer;
• Ziprasidon;
• Zipseil;
• Invest;
• Carbidin;
• Quentiacs;
• Keetilet;
• Clozapine;
• Closasten;
• Klopixol;
• KSEPLion;
• CutiPin;
• Lacwell;
• Leponex;
• Mieragel;
• Depot model;
• Nantaride;
• Normon;
• Orangex;
• Olanzapine;
• Prolinate;
• Suspension;
• Sulpin;
• Reserved;
• Ridonex;
• Rippt;
• Ripotid;
• Dardonal;
• Rispisal;
• Risperidone;
• Rispolept;
• Rispolyx;
• Risset;
• SENORM;
• Servant;
• Cheroolek;
• Serokvel;
• Sonpax;
• Speedan;
• Sulpirid;
• Teraulidgen;
• Thiaprid;
• Tizercin;
• Thiodesine;
• TopRal;
• Toredo;
• Trazine;
• Triftatazine;
• Trucasal;
• Fluanxol;
• Chlorpromazine;
• Egleg;
• Eglonil;
• Escazin;
• Etperazin.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

1 tablet covered with a shell contains chlorprotine 15 or 50 mg; In a blister 10 pcs., in a box of 3 blisters.

pharmachologic effect

Blocks dopamine, histamine, serotonin, alpha-adreno- and cholinoreceptors in the central nervous system.

The testimony of the drug chlorprotine 15 treatments

Psychosis, incl. schizophrenia, depressive states during the period of the climax, the state of excitation associated with fear and voltage, discirculatory encephalopathy, brain injuries, alcoholic delirium, sleep disorders at alarming state; psychosomatic, neurotic disorders in children; in patients with burns; Dermatosis with a stubborn itch.

Contraindications

Absolute: Hypersensitivity, poisoning drugs, inhibiting CNS (including alcohol), the comatose states of any etiology.

Relative: Epilepsy, Parkinsonism, tendency to collapsam, pronounced disorders of the kidney function, liver, heart and breathing, closed-coronal glaucoma, myasthenia, pregnancy, lactation (should be abandoned with breastfeeding), elderly age.

Side effects

Extrapyramidal disorders, increased fatigue, headache, dry mouth, orthostatic hypertension, tachycardia, acceleration disorders, violation, constipation, urination disorders, jaundice, amenorrhea, galathery, gynecomastia, change of libido, violations of carbohydrate exchange, increase in appetite, increase body weight, agranulocytosis, leukopenimat , cancellation syndrome (with sudden cessation of treatment).

Interaction

Enhances the effect of drugs depressing the CNS, incl. alcohol.

Method of application and dose

Inside, during or after eating, not chewing, drinking water. Dosing mode is determined individually. Usually adults: 30-50 mg 3-4 times a day. Treatment starts with low doses, then the dose is gradually raised to the disappearance of signs of the disease. Most dose, as a rule, are prescribed for the night. The daily dose for adults should not exceed 600 mg.

Children: 15-30 mg 3-4 times a day.

Precautions

It is recommended to stop treatment, gradually reducing the dosage. At the time of therapy, taking alcohol, the effects of extreme temperatures, insolation, potentially hazardous activities that require increased attention and speed of psychomotor reactions should be avoided.

Conditions for the storage of the drug chlorprotine 15 treatments

Keep out of the reach of children.

The shelf life of the drug chlorprotine 15 treatments

Do not apply after the expiration date indicated on the package.

Synonyms of nosological groups

N.05.a.f.03 chloroprietary

Composition and form of release of the drug

Tablets covered with film shell from light brown to light yellow color, round, double-screw; View of a break - the core from white to almost white.

Auxiliary substances: Corn starch - 37.5 mg, lactose monohydrate - 135 mg, sucrose - 20 mg, calcium stearate - 3.75 mg, Talc - 3.75 mg.

Film shell composition: HalpRodelloose 2910/5 - 3.6594 mg, macrogol 6000 - 0.1333 mg, macrogol 300 - 0.9166 mg, Talc - 2.4194 mg, titanium Dioxide - 0.3423 mg, yellow oxide dye - 0.029 mg.

10 pieces. - Blister (3) - Cardboard packs.
10 pieces. - Blister (5) - Cardboard packs.

pharmachologic effect

Antipsychotic means (neuroleptic), Tioxanthen derivative. It has antipsychotic, antidepressive, sedative, action, has an alpha-adrenoblocking activity.

It is believed that the antipsychotic effect is related to the blockade of postsynaptic dopamine receptors in the brain. Antiwheat action is associated with the blockade of the chemoreceptor trigger zone oblong brain. A sedative effect is due to an indirect weakening of the activity of the reticular system of the brain barrel. Suppresses the release of most hypothalamus hormones and pituitary glands. However, as a result of the blockade of the inhibitory prolactin of the factor, which inhibits the release of prolactin from the pituitary, the concentration of prolactin increases.

By chemical structure and pharmacological properties Tioxanens are similar to piperazine derivatives of phenothiazine.

Pharmacokinetics

Metabolized in the liver. Available mainly by the kidneys.

Indications

Psychosis and psychotic states, accompanied by anxiety, fear, psychomotor excitation, aggressiveness, incl. with depressive-paranoid, circular, with simple sluggish schizophrenia with psychopathoid and neurosis-like symptoms and other mental illness; Discirculatory encephalopathy, cranial and brain injuries (as part of combined therapy), alcoholic delirium; sleep disorders in somatic diseases; the need for long-term therapy of the state of arousal and anxiety, psychosomatic, neurotic and behavioral disorders in children; convulsive, spastic states in the gastrointestinal tract; Premedication; dermatoses accompanied by a stubborn itch; Allergic reactions.

Contraindications

Depression of the CNS, incl. With alcohol intoxication, barbiturates and other drugs that are inhibitory influence on the CNS, pathological changes in blood pattern, myelodepression, lactation, increased sensitivity to chlorproticsene.

Dosage

Individual. For adults daily dose Various from 10 mg to 600 mg, for children - from 5 mg to 200 mg. The reception frequency and the duration of treatment are determined by the testimony.

Side effects

From the CNS: Psychomotor braking, a weakly expressed extrapyramidal syndrome, increased fatigue, dizziness; In isolated cases, paradoxical enhancement of anxiety is possible, especially in patients with mania or schizophrenia.

From side digestive system: Possible cholestatic jaundice.

From the side of the cardiovascular system: Tachycardia is possible, changes to ECG, orthostatic hypotension.

From the body of the vision: It is possible to clouding the cornea and lens with impaired vision.

From the hematopopitation system: Agranulocytosis, leukocytosis, leukopenia, hemolytic anemia are possible.

From the endocrine system: Possible frequent tides, amenorrhea, galathery, gynecomastia, weakening potency and libido.

From the metabolism: Possible strengthening, impaired carbohydrate exchange, increase the appetite with increasing body weight.

Dermatological reactions: Photosensibination, photodermatitis are possible.

Effects caused by anticholinergic effects: Dry mouth, constipation, accommodation disorders, dysuria.

Medicinal interaction

With simultaneous use with anesthetics, opioid, sedatives, sleeping equipment, antipsychotic drugs, with ethanol, ethanol-containing drugs intensify an inhibitory effect on the CNS.

With simultaneous use with antihypertensive agents, hypotensive effect is enhanced.

With simultaneous use with antiholinergic, antihistamine, anti-playing agents are enhanced anticholinergic effect.

With simultaneous use with the means causing extrapyramidal reactions, it is possible to increase the frequency and severity of extrapyramidal reactions; with levodopoy - possibly the oppression of anti-parkinsonic action of Levodopa; With lithium carbonate - pronounced extrapyramidal symptoms are possible, neurotoxic effect.

With simultaneous use with epinephrine, the alpha-adrenergic effects of epinephrine and the development of this severe arterial hypotension and tachycardia are possible.

With simultaneous use with phenothiazines, metoclopramide, haloperidol, the reserp is the development of extrapyramidal disorders; With quinidine - it is possible to strengthen the oppressive action on the heart.

special instructions

It should not be used in epilepsy, tendency to collapse, parkinsonism, heart defects in the stage of decompensation, tachycardia, atherosclerosis of brain vessels, pronounced violations of the liver and kidney function, violations of blood formation, cachexia, in old age.

If necessary, the use of chlorproticsena should compare the risk and benefit of treatment in patients with chronic alcoholism, diseases of the cardiovascular system (increased risk of transient arterial hypotension), Reee syndrome, as well as when glauer or predisposition to it, peptic disease Stomach I. duodenal gut, urine delay, epileptic seizures, increased sensitivity to other thiochantes or phenothiazins.

When applying chlorprotine is possible, false positive results of the immunological test for pregnancy using urine, as well as false-positive results of urine study on bilirubin.

During the treatment period, not to use alcohol.

Impact on the ability to driving vehicles and control mechanisms

Do not apply in old age.

Tablets "Chlorprotine" (or "Kentiv chlorprichient") - a drug that has an anticonvulsant, antipsychotic, neuroleptic, analgesic effect. It can be appointed by doctors with a combination of problems, ranging from depression and ending with a brain injury. This article contains detailed information on the chloroprotine medicine: from which it is prescribed, which contraindications have, which side effects cause. You will also learn how doctors and patients themselves respond about him.

Indications for use

Medicine "Chlorprotic", the instruction to which is always included in the package, can be assigned with such health problems:

Violation of behavioral reactions in children.

Psychosites, including schizophrenia and manic syndrome, accompanied by fear, aggression, anxiety.

Neurosis, depression.

Confusion of consciousness, excitement in the elderly.

Tachycardia is an increase in heart rate.

Problems with accommodation - eye ability to consider objects at different distances.

Dizziness.

Strong sweating.

Increase body weight.

Dysmenorrhea is a symptom characteristic of women who use the chloroprotine medicine. The effect of these tablets is such that when they receive a fair sex in the days of menstruation, severe pain appear in the lower abdomen.

Skin rashes.

Reduced potency.

Raising appetite.

Galactere - isolation from nipples of liquid non-breast milk.

The emergence of benign leukopenia.

Gynecomastia is an increase in breast glands in men.

Overdose

If the patient randomly or deliberately accepted in a high dose, the chloroprietary medicine, the consequences of such an inattentive attitude to themselves may be sad. Symptoms of overdose is: drowsiness, comatose state, tachycardia, hot, tumping consciousness, respiratory failure, convulsions.

Treatment in this case should be operational. Be sure to call the doctor, and before it arrives it is necessary to rinse the stomach, to give a patient an activated carbon or "enterosgel". It is important to remember that it is impossible to cause vomiting, because it can lead to inhalation by a person's own vomit. Before the emergency arrival, it is necessary to provide a patient bedding, control the temperature of its body, as well as blood pressure.

Pros of drug

Medicine "chlorprotic" is effective tool In the fight against panic and maniacal states at the initial stage.

Side effects are much smaller than other similar medicines.

Cons of drug

It causes a strong dependence, so the patient is hard to go to another tool.

With severe mental disorders, the medicine may not help to fully.

Individual hypersensitivity to the medicine.

Opinions of patients

The drug "Chloroprietary" Reviews from people have ambiguous: someone praises this medication, and some of his zealo criticize. They have a positively responding to those patients who have helped to cope with depressions, neurosis, psychosis. The patients themselves note the fact that after the treatment of "chloroprotic", their condition improved significantly, they truly began to relax and be content with the life of which it is. If earlier these patients could not sleep normally, then after the treatment with this medicine, they cease to complain about sleep problems.

However, the means of "chlorprotic" reviews have not only flattering, but also negative. Some patients say that after treatment, this medicine has deteriorated a state of health. However, the situation with the psyche was normal. But at the same time, such people are unhappy with this medicine, since after therapy they feel bad: they have a head of her head, in front of them, there is lethargy, fatigue, there is no desire to work.

Opinions of doctors

Psychotherapists also recommend their patients with chlorprichient medicine. Reviews from doctors such tablets are only positive. Experts really prove that the effect of this drug is, and it is visible. Therefore, their patients coming to them on the reception, they prescribe this medication.

Psychotherapists also explain why some people do not like this drug and why they have such side effects. The fact is that if a person is independently treated with chloroprotic pills without appointments of a doctor, the effect of them can really be negative. To read the instructions are not enough, since each patient is individual and the same dosage is suitable for him, which is indicated in the liner. Yes, and diagnoses of people are different. Therefore, you need to make a consultation to the specialists, follow their recommendations on how to take pills, in what quantity and how long. Among patients who comply with the appointments of the doctor, the drug "Chlorproticss" reviews have only positive.

According to the composition and form of release, the medication described in this article has similar means. It is the "TrukroCal" pills, "Chloroprtexen Lechiva". They contain the same acting component - chlorprotine hydrochloride. But for the reachable effect, the tool has more analogues. So, replace the pills, which the article is devoted to the pills of "Clopixol", "Phluuhanxol", solutions for the injection of Klopixlo Depot, "Phluuanxol Depot", "Amyizepin". The drug "Chloroprietary", the analogues of which are also very effective, can be purchased in any pharmacy.

Special instructions and contraindications

It is forbidden to take this medicine in epilepsy, problems with a heart, with violations of the liver, kidney, bloodstream.

If a woman is treated with the drug "Chloroprietary", she can have incorrect results of pregnancy test, in connection with which it should know this feature of the medication. The same applies to the results of the study of urine on bilirubin. The "chlorproticsene" means in this case can also show a false positive result.

At the time of therapy, this medicine is prohibited to use any alcoholic beverages.

During the treatment period, it is necessary to refrain from dangerous work, as well as from such activities that requires increased attention.

If the patient has diseases of the heart and vessels, glaucoma or predisposition to it, the ulcer of the stomach, then before treatment, you need to compare the risk and benefit for such categories of patients.

With increased sensitivity to the constituent drugs, during a comatose state, in the vascular collapse, it is impossible to use "chlorprichny".

Reception and at a peochromocytoma - hormonal tumor of chromaffine cells of the adrenaline system of adrenal or non-propellant localization is prohibited.

Cost

The tool "chloroprotine", the price of which depends on the dosage of the produced tablets, the location of the pharmacy (if you buy in the capital, then the medicine will be more expensive than to acquire it in other cities), as well as from the cheating of the very trading point itself, is not expensive. On average, the cost of pill (15 mg) in the amount of 30 pieces varies within 220-260 rubles. And for tablets, 50 mg dosage will have to give from 330 to 370 rubles per pack.

Storage conditions, shelf life, manufacturer

To save the medicine "Chlorprotic" should be in the place inaccessible for kids. The optimal storage temperature should be at least 10 and no more than 25 degrees. The shelf life of the drug is 3 years, after which it is necessary to get rid of the pills.

Application during pregnancy

The safety of medication "Chlorprotic" during the location of a woman in an interesting position has not been studied. Therefore, it is possible to use this tool during pregnancy in the case when the benefits of this therapy for the future mother exceeds the risk for the fetus.

In persons who took these tablets during the third trimester of pregnancy, children were born with extrapyramidal disorders, as well as with the abolition syndrome, which is characterized by such negative manifestations as drowsiness, respiratory disruption, hypertension, hypotension, tremor. And all this can be observed in newborns, whose moms were treated with the help of the "chlorprotic network". Although many kids have the above-described symptoms disappeared by themselves within a few days without special treatment. But there were such cases when it had to lie in a hospital for monitoring and therapy. Therefore, in order to protect your future kid from such problems, you should not use these pills during pregnancy.

Interaction with other drugs of chlorprotic tablets

The use of this medication together with drugs containing ethanol, as well as with sleeping pills, sedatives, drugs can enhance the oppressive effect of the product, to which the article is devoted to the central nervous system. With the simultaneous admission of these tablets with adrenaline, tachycardia and arterial hypotension may be observed in patients. Also, this means is able to reduce the threshold of convulsive activity, therefore, with patients suffering from epilepsy, additional correction of the dosage of anti-epileptic medicines is required. And the simultaneous reception of drugs with Tablets "Haloperidol", "Replanted", "Metoklopramid" can cause extrapyramidal disorders.

Now you know a lot about the "chlorprotic network". Analogs of this drug are also known. We told, in what cases do the doctor prescribe a medicine and which dosage. It was determined that this is a serious medicine, with the improper use of which the patients may have negative effects. Doctors are positively responding about chloroprotine tablets, but at the same time they strongly recommend their patients to comply with the dosing regime. After all, with improper therapy, humans may have health problems.