Vitamin B1 plays an important role in the work of the human body. In recent years, doctors have to observe a disappointing picture: gradually the number of cases increaseswhen a certain group of patients accounts for artificial way Enter this substance. Such patients are most often prescribed by a special preparation - thiamine hydrochloride.

Thiamine, like any other drug Treatment, requires caution. And in order not to harm, it is necessary to enter this substance, accurately observing the instructions of the instruction.

Properties of drug

The product under consideration is a solution intended for intramuscular injections. It looks like a colorless liquid with a characteristic mesmer smell. The drug is sold in ampoules made of neutral glass. Ampoules are additionally packed in boxes, each of which contains 5 or 10 pieces.

As part of the drug under consideration, the main active component Tyamin hydrochloride is performing. The content of the active substance in 1 ml of the medication is 50 mg. Also, this medical product also contains additional components - unitiol and purified water. It is worth saying that recently doctors are increasingly prescribed by the patient an analogue of Tiamine - Benevron.

The benefits of thiamine for the human body lies in his ability to restore the work of all its bodies. The fact is that Vitamin B1 takes part in many exchange reactions. Pthe dust of the injection of the muscle is starting to absorb immediately and spread throughout the body. It is most concentrated in the liver tissues, nervous system, in myocardium and skeletal muscles, since it is they who have the greatest need for this substance.

Finding into tissues of the body, thiamine hydrochloride is subjected to the process of phosphorylation, as a result of which transforms into the active coofer of some exchange reactions. The participation of thiamine is the metabolism of lipids, carbohydrates and proteins. Certain forms of thiamine ensure the normal implementation of the process of transferring the nerve impulse in synapses. After providing its effects, the remnants of the drug are neutralized by the liver, and then removed by the kidneys along with the urine.

Indications for reception

The instructions provide a sufficiently large list of states in which thiamine is recommended to be used in the form of injections.

In any case, before starting treatment, it will not hurt to consult with the doctor.

Vitamin B1 deficiency

B1 (instructions for use contains a weight list of indications) refers to a group of substances that the human body is not able to produce independently. Therefore, he must arrive daily from the outside. A constant lack of vitamin B1 over time can provoke the development of avitaminosis, and this is fraught with violation exchange processes, loss by the body of the ability to allocate energy from incoming food. All this in the end negatively affects the work of the heart, muscles and nerve endings. With a long lack of therapeutic measures, neurological disorders, constipation, atrophy and other problems are developing.

For thiamine deficiency Indicate the following signs:

• the participation of the heart;
• pain in caviar;
• headaches;
• worsening memory;
• high fatigue;
• depressive condition;
• floodiness and irritability;
• hand shakes;
• dyspnea;
• diarrhea.

If any of them is found, it is necessary to immediately consult a doctor so that it decides whether to prescribe a patient of thiamine hydrochloride.

Instructions for use

Before the first use of the drug thiamine in ampoules (instructions for use must be learned), you must consult with a doctor who should pick up daily dose and the duration of treatment, taking into account the characteristics of the patient. From the instructions for the drug it follows that thiamine is designed for intramuscular administration. The first days the solution is introduced into the body in small doses. At the initial stage, a dosage of 0.5 ml of 5% solution is adhered. In the absence of negative reactions from the body, the dose of the drug is gradually increased.

Valid dosage

Before starting treatment, you need to get acquainted with the instruction and find out which dosage should be followed by the introduction of the solution intramuscularly or internal medication. Human organism for normal functioning Miscellaneous amount of substance is required. It all depends on the characteristics of the body, age, as well as other factors.

If you proceed from the age of patients, then depending on this parameter you can select the following recommended dosages:

• up to 6 months - 0.2 mg per day;
• from 6 months to a year - 0.4 mg;
• from 1 to 5 years - 0.6 mg;
• from 5 to 14 years - 0.9 mg;
• from 14 to 18 years 1.2 mg;
• from 18 to 30 years old 1.0 mg.

Women during baby tooling It is allowed to introduce the drug in the dosage of not more than 1.4 mg per day.

In any case, the patient necessarily first needs to be examined by a doctor so that he can choose a safe dosage and reception course. You can do it yourself and all the more damage to yourself is prohibited. After all, during treatment, it may be necessary to adjust the dosage of the drug, which is correct to do only by a qualified technician.

Adult patients with thiamine hydrochloride or thiamine bromide (instructions for use in each case should be studied) are administered in a dosage from 25 to 50 mg. This concentration of the active substance corresponds to 0.5 ml of solution. If we talk about children, then for them the dosage will be 0.25 ml of solution. Typically, treatment is carried out by a course of 10-30 days.

Of the available treatment options, it is recommended to choose the oral intake of vitamin. The injection method is resorted only when the reception of the tablets becomes impossible. This may be due to a pre-or postoperative period, progressive malabsorption syndrome, strong nauseaflowing with constant vomit.

Contraindications and side effects

If you carefully read the instruction, then you can find out that the drug has not so much contraindications. First of all, it should be abandoned by people having increased sensitivity to the components of thiamine. Pricks can not be put and patients with hypervitaminosis of thiamine.

If compared to this recommendation The following consequences of the rebuilding of vitamin B1 can occur - spasm in a sip, shortness of breath, tremor, high sweating. It is noteworthy that hypervitaminosis is quite rare, since thiamine belongs to the group of non-toxic substances. This state usually arises due to drug overdose.

The practical experience of the use of the drug confirms its full safety. Side effects, if arising, then in very rare cases and are manifested by allergic reactions. Most frequent among them are redness, skin itch And urticaria. In some cases, you can observe the otkinka. When developing heavier cases, anaphylactic shock may occur. The emergence of any of the above symptoms is a sufficient basis in order to stop taking the drug and contact your doctor.

Quite often after injection procedures, unpleasant symptoms may occur both in the place of injections, where you can watch redness, small edema and testing painful feelings. However, it is not necessary to worry about this, because it is normal. More often than other such side effects have to be observed in women in the menopacteric period. Also, these symptoms may be disturbed by people suffering from chronic alcoholism.

Overdose and its symptoms

If the patient does not respect the prescribed dosage of the drug, it can lead to overdose with the relevant consequences. Typically, the body observed after injections manifest themselves with greater force. However, some of the patients may have other symptoms. If it is too long to put injections in increased amounts of solution, then this can cause strong headaches. Sometimes deviation from the recommended scheme Treatment can lead to the development of tremor and the participation of heart abbreviations.

Some patients may be disturbed insomnia and increased excitability. If any similar state of unexplained nature is found, it is necessary to immediately consult a doctor for help. Treatment in such cases is usually reduced to the elimination of the observed symptoms by stopping the administration of the thiamine solution.

Interaction with other drugs

Before proceeding with treatment, it is necessary to notify the doctor about the preparations already taken. The fact is that Tiamine is well combined not with all medicines. So, it cannot be administered simultaneously with the medications containing sulphides, since the latter neutralize the specified substance. Pyridoxine is also negative to thiamine, slowing the conversion of the solution into a biologically active form. It is unacceptable to put injections of thiamine hydrochloride along with the injections of cyanocobalamin, since with such a combination the risk of developing allergic reactions increases.

It should be known that when entering alkaline and neutral solutions, vitamin B1 becomes unstable. For this reason it is undesirable to mix it With carbonates, barbiturates and citrates. It is unacceptable to add to the thiamine solution and a number of antibiotics, since vitamin is able to destroy antibacterial substances.

With caution, it is necessary to use a solution for the injection of thiamine hydrochloride with depolarizing muscle relaxants, since the first has the ability to lower the positive effect of the latter. At the time of treatment, it is necessary to abandon the use of alcohol-containing drinks, since ethanol slows down the assimilation of vitamin organism.

The body of each person should have a lot of different vitamins, including vitamin B1 in sufficient quantity. His drawback can negatively affect the work of many important bodies and systems, creating favorable conditions for the development of severe diseases. Therefore, it is important to prevent situations where the deficit of this substance occurs in the body. Eliminate vitamin B1 lacking can help injections of a special thiamine hydrochloride drug. However, it is necessary to make injections.

It is not enough just to familiarize yourself with the instructions for the introduction of the thiamine solution and follow its instructions. First of all, it is necessary to correctly determine the dosage and the diagram of the introduction of the drug that need to pick up Taking into account the characteristics of the patient's condition. Therefore, at first the patient must be examined by a specialist. And if he does not find contraindications to this drug, it will have to regularly go to the procedures for the administration of the thiamine hydrochloride solution intramuscularly.

The thiamine chloride solution is the source of WIT. B1 is used to regulate metabolic processes.

Indications for use

The main indication to the use of such a drug as thiamine chloride are hypovitaminity, as well as the lack of WIT. IN 1. Used to carry out complex therapy at:

• Inony Inherent
• Radiculite
• Dystrophic changes in myocardium
• Neuly and neuralgia
• Thyrotoxicosis
• Impaired absorption of the mucous and small intestines
• Psoriasis and other skin diseases
• Endarteriti.
• Broken coronary blood circulation
• Palsy
• Peripheral Parese
• Intoxication.

Structure

One milliliter solution for intramuscular administration contains 50 mg of the main component, which is tiamine chloride. Additionally there are unitiol, purified water.

Medical properties

For many, it is immediately difficult to determine which vitamin lies under the title of thiamine chloride. This is Vit. B1, it is water-soluble. If you get into the body, the process of phosphorus is passed during which it is converted to kocarboxylase, which is a coenzyme, takes part in the flow of a set of fermatative reactions.

WIT. B1 is an active participant in metabolic processes, necessary to ensure nerve impulses in synapses.

Form release

Price from 25 to 49 rubles.

The solution is represented by a glorified liquid with a pronounced aroma. Available in 1 ml ampoules, 10 AMPs are placed inside the package. The drug thiamine chloride in tablets is not made.

Tiamine Chloride: Instructions for use

The injection must be done intramuscularly. The implementation of the injection of the drug should begin using minimal dosages (not more than 0.5 milliliters of a 5% solution), in the absence of side symptoms, you can increase the dose.

For adults, the introduction of 0.05 g of Vit is shown. B1, which corresponds to 1 millilitra 5% solution. Making injections will need daily once a day. The course of therapeutic therapy is from 10 to 30 injections.

Application during pregnancy and gv

This drug is appointed to use according to the standard scheme.

Contraindications

The only contraindication to the conduct of vitamin therapy is the individual sensitivity to the synthetic analogue of Vit.V1.

Precautions

The parenteral administration of a vitaminized means is shown only in the absence of the possibility of taking the drug inside. In the presence of encephalopathy Wernik, the use of drugs based on dextrose must be carried out a little earlier than the use of thiamine.

Cross drug interactions

One should not combine the bright introduction of other drugs in groups, as it is observed difficulty converting thiamine into active metabolites. It should be borne in mind that cyanocobalamin is able to strengthen the anesthetic effect of thiamine.

Before administration, it is impossible to connect the synthetic analogue of VIT. B1 with stertoicin or penicillin (the destruction of the main antibacterial components is observed), with nicotine acid (the complete destruction of thiamine occurs).

The drug significantly reduces the effectiveness of depolarizing muscle relaxants.

Side effects

During the vitamin therapy, it may be observed:

• Allergic manifestations (itching, rashes by type of urticaria, swelling of quinque, excessive sweating, violation heart Rhythm, rather rarely - anaphylactic shock)
• Local painful sensations caused by low pH balance of solutions.

Overdose

There is an increase in adverse symptoms. When receiving elevated dosages, the appearance of signs of hyperthyroidism is not excluded (tremor, strong headaches, excessive excitement, change of the pulse frequency, sleep disorder).

Symptomatic therapy is shown.

Storage conditions and shelf life

The ampoules should be stored in the original packaging in a dark place at a temperature not exceeding 25 S. The vitaminized solution can be used for 3 years from the moment of production.

Analogs

Microgen, Russia

Price from 36 to 364 rubles.

Cocarboxylase exhibits a coherent effect, as it is a Tiamine coenager. It is prescribed for the treatment of diseases of the CSS, alcoholism, renal and respiratory failure. Produced in the form of lyophilisate for the manufacture of the solution.

Pros:

• Low price
• Wide spectrum of action
• Appointed to children.

Minuses:

• Need a recipe for purchase.
• Do not combine with other vitamins B-Group
• Again, Athony can develop.

Tiamine Chloride Darnitsa (Vitamin B1 Darnitsa)

International nonpatient name

Dosage form

Solution for injection 5%

Structure

1 ml of solution contains

active substance - thiamine hydrochloride 50 mg

excipients: Unitiol, water for injection

Description

Transparent colorless or slightly yellowish liquid with a weak characteristic odor.

Pharmacotherapeutic group

Vitamins. Vitamin B1.

ATH A11DA01 code

Pharmacological properties

Pharmacokinetics.

The drug is well absorbed. Phosphorylation passes in the liver. Accumulates in the liver, heart, brain, kidneys, spleen. It is highlighted in liver and kidneys, about 8-10% - unchanged.

Pharmacodynamics

Tiamine Chloride Darnitsa - synthetic preparation Vitamin B1 belongs to water soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into kocarboxylase, which is a coherent of many enzyme reactions. Vitamin B1 plays an important role in the exchange of substances and neuro-reflex regulation, has an impact on the conduct of nervous excitement in synapses, has a gangli-blocking and strip-like effect. The drug can weaken the strip-like action of depolarizing muscle relaxants.

Indications for use

- hypovitaminosis and vitaminosis B1

Treatment of burns, long fever in comprehensive therapy

Neuritis, polyneurite, radiculitis, neuralgia, peripheral paralympics, encephalopathy, neurasthenia

Ulcery disease of the stomach and 12-rosewood, intestinal atony, chronic liver damage

Myocardial Distropy, Enctery

Dermatoses of neurogenic origin, pyodermia, eczema, psoriasis

Method of application and dose

Adults.

The drug is prescribed intramuscularly (deep into the muscle) at a dose of 25-50 mg (0.5-1 ml) 1 time per day, daily. Introductions begin with small doses - no more than 25 mg (0.5 ml of 5% solution) and only under the condition of good tolerability are introduced higher doses - 50 mg (1 ml of 5% solution). Course treatment - 10-30 injections.

Encephalopathy Vernika-Korsakov: The drug is prescribed intramuscularly (deep into the muscle) at a dose of 50-100 mg (1-2 ml of 5% solution) 2 times a day before clinical improvement. The probability of developing an allergic reaction to the introduction of vitamin B1 should be taken into account.

Children over 8 years old.

The drug is prescribed at a dose of 12.5 mg (0.25 ml of 5% solution) 1 time per day, daily. Course treatment - 10-30 injections.

Side effects

Tachycardia, feeling heartbeat, collapse

Headache, Dizziness, Anxiety, Paresthesia

Defeat of optic nerve

Welcome breathing, shortness of breath

Weight swallowing, nausea, intestinal hemorrhages

Hyperemia, itching

Dermatitis, rash, urticaria, swelling of quinque, bronchospasty syndrome with convulsions, anaphylactic shock

Violation of liver enzyme activity

- general violations: Increased sweating, chills, tremor, total weakness, swelling, fever

Reactions at the injection site: rash, itching

Others: The phenomenon of synaptopilegia - the ability of thiamine to form complexes with different mediators may be accompanied by a decrease arterial pressure, the occurrence of heart arrhythmias, disruption of the reduction of skeletal (including respiratory) muscles, inhibition of the central nervous system; TIAMIN chloride contributes to the formation of staphylococcal resistance to antibiotics.

Contraindications

Increased sensitivity to the components of the drug

Allergic diseases

Idiosyncrasy

Precloslimatic and menopausal periods in women

Children's age up to 8 years.

Medicinal interactions

With the joint use of the drug with other drugs, it is possible: with depolarizing muscle relaxants (suucamenia chloride), derivatives of choline - the weakening of their therapeutic action;

with thiosemicarbazone, 5-fluorouracil - inhibition of the activity of thiamine;

with caffeine, preparations containing sulfur and estrogens - increasing the need of the body in thiamine;

with anticonvulsant drugs (phenobarbital, phenytoin, carbamazepine), digoxin, indomethacin, antacid drugs - development of thiamine deficiency;

with cyanocobalamin, pyridoxine - The difficulty of converting thiamine into phosphorylated biologically active shape and enhance its allergizing action. The simultaneous parenteral administration of thiamine with pyridoxine (vitamin B6) or cyanocobalamin (vitamin B12) is not recommended;

with ethanol - slow down the suction rate of thiamine.

with adrenomimetics, sympathomimetics - weakening their therapeutic action.

When intravenous administration simultaneously with solutions containing sodium hydrosulfite as an antioxidant or a preservative, thiamine is unstable.

TIAMIN chloride should not be mixed in one syringe:

with benzylpenicillin or streptomycin, as this will lead to the destruction of antibiotics;

with nicotine acid or solutions containing sulphites, as this will lead to the destruction of thiamine;

with carbonates, citrates, barbiturates, with Cu2 +, iodides, iron-ammonium citrate, taninic acid, since thiamine is unstable in alkaline and neutral solutions.

special instructions

Before the parenteral use of the thiamine chloride solution, it is necessary to carry out a skin test for individual sensitivity to the drug. After the injection, control is needed for 30 minutes due to the possibility of severe allergic reactions.

Anaphylactic reactions develop more often after intravenous administration In high doses.

Thiamine injections are preferably not previously done than 12 hours after the injection of pyridoxine.

With intramuscular administration, the drug should be introduced deep into the muscle, with intravenous - slowly.

Intramuscular I. subcutaneous injections Painful due to low pH solution.

The daily need for vitamin B1: for adult men - 1.2-2.1 mg, for elderly people - 1.2-1.4 mg, for women - 1.1-1.5 mg with adding 0.4 mg Pregnant and 0.6 mg - women during breastfeeding period, for children, depending on age, - 0.3-0.5 mg.

It is impossible to use the drug as a replacement of a balanced diet, only in a complex with diet-andotherapy.

The injection form of the drug must be used in the treatment of patients with impaired absorption in the intestine or with resection of the stomach, with the impossibility of tiamine intake in tablet form (nausea, vomiting, pre-and postoperative period), as well as with severe forms of the disease or at the beginning of treatment for faster achievement therapeutic effect.

Caution is prescribed when increased excitability nervous system, hyperacid forms peptic disease duodenal gut.

At encephalopathy, the Vernika before the introduction of glucose must be taken thiamine.

If allergy is found to Vitamin B1, the patient cancel rice, buckwheat, meat, bread (varieties baked from coarse grinding).

In patients with alcoholism, it is possible to strengthen the symptoms side effect drug.

Thiamine can weaken the action of depolarizing muscle relaxants, adrenolytic and sympathomimetic means.

The drug (when taking high doses) can distort the results in the determination of theophylline in the blood serum by a spectrophotometric method and urobinogen using the Erlich reagent.

Pregnancy, Lactation

It is possible to use the drug during pregnancy or breastfeeding according to testimony in recommended doses.

Children

For children, a 2.5% solution of thiamine chloride is usually used. It is allowed to introduce a 5% solution to children over 8 years old.

Features of influence drug on the ability to control vehicles and especially dangerous mechanisms

During treatment, caution should be taken when driven by vehicles and work with complex mechanisms In connection with the possibility of development side Effects From the nervous system.

Overdose

Symptoms: It is possible to strengthen the symptoms of the side effects of the drug - hypercoagulation, a violation of purine exchange.

Treatment:cancellation of the drug, symptomatic therapy.

Release form and packaging

1 ml of the drug in ampoules glass.

The ampoule is sticking a paper label with self-adhesive coating or apply paint deep printing for glass products.

5 ampoules along with a knife for opening the ampoules are placed in the contour cellular packaging (cassette).

Two contour cell packaging along with the instructions for medical application In state and Russian, placed in a pack.

10 ampoules, along with the instructions for medical use in public and Russian languages \u200b\u200band the knife for opening the ampoules are inserted into a box with a corrugated liner.

When packing ampoules with a colored rings of a break, or a color point of a break, laying knives for opening the ampoules is excluded.

Storage conditions

Store in the original packaging at a temperature not higher than 25 ° C. Do not freeze.

Keep out of the reach of children!

Storage term

Not to use after the expiration date

Conditions of vacation from pharmacies

On prescription

Manufacturer

Chao "Pharmaceutical Firm" Darnitsa "

Ukraine, 02093, Kiev, ul. Borispolskaya, 13.

Owner of the registration certificate

Chao "Pharmaceutical Firm" Darnitsa ", Ukraine

The address of the organization hosting on the territory of the Republic of Kazakhstan Claims from consumers for product quality:

telephone: (+ 727) 2424328

The address of the organization responsible for the post-registration monitoring of the drug safety:

050043, Almaty, ul. Navoi 68, sq.49

telephone: (+ 727) 2424328

e-mail: [Email Protected]

TIAMIN chloride is needed to patients with metabolic disorders. It is advisable to use in coordination with the doctor.

International non-proprietary title

Latin name - Thiamin Chloride.

ATX and registration number

Code within ATC - A11DA01. Drug registration number - P N015467 / 01.

Pharmacotherapeutic group

Belongs to the group of funds for the normalization of the patient's metabolism.

Mechanism of action

Pharmacodynamics of the drug: Vitamin B1 belongs to the group of water soluble. Phosphorylation processes occurring in the body contribute to its conversion to caocarboxylase, which regulates many enzyme responses in the human body.

Thiamine chloride helps a normal protein, fatty and carbohydrate exchange. Vitamin also takes part in the processes of nervous arousal, which flow in synapses.

Pharmacokinetics Medicines: The concentration in the blood when taking the means can be characterized as low, but in the blood plasma contains a lot of free vitamin. The process of phosphorylation is carried out in the liver. Maximum concentrated in the liver, brain, spleen, kidneys and heart. The elimination occurs through the kidneys and intestines.

Composition and form of release

You can purchase a medicine only in the form of a solution for intramuscular administration. In 1 ampoule with 1 ml solution there is 50 mg of thiamine chloride. Each box contains 10 ampoules. In the form of tablets, the tool is not performed.

Indications for use

TIAMIN chloride should be written out to patients if they have the following pathologies:

• , eczema;
• disorders of suction in the intestines;
• thyrotoxicosis;
• neuritis, radiculitis, neuralgia;
• myocardial dystrophy;
• paralysis;
• intestine atony;
• pathology of coronary blood circulation;
• peripheral paresis;
• hypovitaminosis and avitaminosis.

Contraindications

The drug cannot be used in the presence of a patient with increased susceptibility to thiamine.

How to apply?

Patients should be familiar with the instructions for the use of the drug. The dosage should be specified by a doctor who assigns a means. Below will be estimated doses for use with different diseases.

The five percent solution of thiamine is administered intramuscularly (injections). At the beginning of therapy, it is recommended to treat small doses of the drug. This is not more than 0.5 ml of the solution of the specified concentration. If the patient has a well tolerate such treatment, you can increase the dose in injections. Therapeutic course is 10-30 injections.

special instructions

Thiamine chloride in ampoules can be used to improve hair status. At the same time, it is important in addition to such treatment to carefully care for hair.

During pregnancy and lactation

Baby I. baby breast-feeding Are not contraindications for conducting therapy with this drug.

In childhood

Purpose Children is made with caution, the dosage is 0.0125 g for 1 month.

In old age

An elderly age should not become a reason for banning the reception. The only thing to remember is that additional control of the doctor is needed.

When violations of the liver function

Hepatic pathologies are not contraindicated for treatment with a means.

With violations of the kidney function

Side Effects of the Tiamine Chloride Preparation

As adverse Reactions May arise:

• allergic reactions (urticaria, swelling of quinque, skin itching, anaphylactic shock);
• tachycardia and sweating;
• painness at the place of injection.

Impact on the management of the vehicle

The drug does not act negatively to the patient's ability to control the machine.

Overdose

Medicinal interaction of thiamine chloride

Thiamine tends to reduce the pharmacological activity of Redernham, sleeping pills (hypotensive and sleeping action It becomes less pronounced), fantolamine, suucametonium iodide, such sympatholitic, like octadine and reserpine.

It is not recommended to combine the parenteral administration of thiamine and ,. The latter vitamin contributes to a more pronounced manifestation of allergic reactions caused by the treatment of vitamin B1. Pyridoxine makes it difficult to transformation of thiamine into a biologically active form.

Thiamine cannot be combined with solutions that contain sulfites (its complete decay occurs). Also recommended a combination with, since the decay of thiamine occurs.

Compatible with alcohol

During the treatment, taking alcoholic drinks is undesirable.

Tiamine Chloride Holiday Conditions from Pharmacies

Jobs only on the doctor's prescription.

Price

The cost of the drug is low and starts from 40 rubles in Russia.

Storage conditions

Storage should be carried out in a dark place at room temperature.

Shelf life

Indications for use:
TIAMIN chloride is used to treat hypo- and avitaminosis B1, for the treatment of neurites, polyneurite, radiculitis, neuralgium, peripheral paralysis, encephalopathy, neurasthenia, peptic ulcers of the stomach and 12-robes, intestinal atonia, liver disease, dystrophy of myocardium, peripheral vessels ( ENDARTERIT, etc.), dermatosis of neurogenic origin, with skin, podermia, eczema, psoriasis.

Pharmachologic effect:
Pharmacodynamics
TIAMIN chloride is a synthetic product of vitamin B1, refers to water-soluble vitamins. In the human body, as a result of phosphorylation processes, it turns into a kocarboxylase, which is a coenser of many enzyme reactions. Vitamin B1 plays an important role in carbohydrate, protein and fat exchangeAlso in the processes of nervous excitement in synapses.

Pharmactnetic
The drug in parenteral administration quickly enters blood, more or less evenly distributed between organs and tissues. Phosphorylation occurs in the liver. Accumulates in the liver, heart, brain, kidneys, spleen. It is highlighted by the liver and kidneys, within 8-10% - unchanged.

Thiamine chloride method of use and dose:
The solution of thiamine chloride is injected intramuscularly; adults - 0.05 g (1 ml of 5% solution), 1 time every day, every day; Children - 0.0125 g (0.25 ml of 5% solution). On the course of treatment -10-30 injections.

Thiamine chloride contraindications:
Hypervisionability allergic diseases, idiosyncrasy, hypertonic disease. With caution to prescribe with an increased excitability of the nervous system, duodenal ulcerative disease (hyperacid forms).

Tiamine Chloride Side effects:
Allergic reactions (skin itching, urticaria, swelling), anaphylactic shock are possible. These reactions occur with the tendency to allergies, in women in menopausal and preclimberic periods, in sick alcoholism.

Pregnancy:
When using the product with pregnant and nursing breasts, women, no negative effects were detected.

Overdose:
In case of overdose, it is possible to enhance the symptoms of the side effect of the product. When used in large doses, signs of hyperthyroidism may appear for a long time: headache, excitation, tremor, increase in the frequency of the pulse, insomnia.
Treatment: stop receiving the product; Treatment is symptomatic.

Use with other drugs:
The thiamine chloride solution should not be mixed with solutions containing sulfites, since it is completely disintegrated. Simultaneous parenteral administration of thiamine chloride with vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin), since, respectively, the first increases the allergizing effect of thiamine, and the second inhibits its transformation into phosphorylated biologically active form.
It is not necessary to mix in the same syringe of thiamine chloride with penicillin or streptomycin (antibiotic destruction occurs), also thiamine chloride and nicotinic acid (Tiamine's destruction occurs).

Long-term treatment of anticonvulsant products (phenobarbital, phenytoin, carbamazepine), also sharing Product with digoxin, indomethacin, antacid products can lead to thiamine deficiency. Tyosemicarbazone and 5-Fluorfuranil inhibit vitamin B1 activity. The use of caffeine, products containing sulfur and estrogens increases the need for thiamine. Thiamine weakens the strip-like action of depolarizing muscle relaxants (dithiline and others).

Release form:
Injection.
1 ml ampoules; 10 ampoules in a bundle.

Storage conditions:
Store in an inaccessible to kids protected from light place at a temperature not higher than 25 ° C.
Storage period - 3 years.
Recommended by recipe.

Synonyms:
Vitamin B1.

Thiamine chloride composition:
International and Chemical Names: Thiamin, Vitamin B1, 3 - [(4-amino-2-methyl-5-pyrimidinyl) methyl] -5- (2-oxyethyl) -4-methyl-thiazoly chloride hydrochloride; The main physico-chemical properties: colorless transparent or slightly yellowish liquid.

1 ml of the product contains thiamine chloride (in terms of 100% substance) 50.0 mg; Auxiliary substances: unitiol, water for injection.

Additionally:
The injection shape of the product must be used in the treatment of suction disorders in the intestines, also with severe forms of the disease or from the beginning of treatment for a faster achievement of the therapeutic effect. To begin the parenteral administration of thiamine chloride is recommended with small doses (no more than 0.5 ml of 5% solution), and only with good tolerability, higher doses are introduced. With intramuscular administration, the product should be administered deep into the muscle, with intravenous - slowly. Subcutaneous, and sometimes intramuscular injections are painful due to low pH solutions. In women in menopausal and preclimacterial periods, also in cases of alcoholism, it is possible to strengthen the symptoms of the side effects of the product.

Manufacturer
LTD " Pharmaceutical company "Health"

Attention!
Before applying medication "Thiamine chloride" It is necessary to consult with the doctor.
The instruction is provided solely for familiarization with " Thiamine chloride».