Cephazolin: how to breed novocaine for injections to children and adults? Cefasoline. Cefasoline Enclosure Solution - Instructions for the drug, application, price, form of release, analogues of cefazolin Allergic reactions
Cephazolin is an antibiotic of the cephalosporin group of the first generation, which is a semi-synthetic antimicrobial drug.
This drug negatively affects many pathogenic microorganisms. Cefasoline comes on sale in the form of injection powder. Finding into the gastrointestinal tract The active substance disintegrates and does not have time to be absorbed into the blood, so the medicine is not produced in the form of tablets.
In this article, we will consider for what doctors prescribe cefazoline injections, including instructions for use, analogues and prices for this medicinal product in pharmacies. Real feedback people who have already used cefasoline can be found in the comments.
Composition and form of release
Cephazoline is produced in the form of a hygroscopic white powder in glass bottles for the preparation of a solution for intravenous and intramuscular injections.
- The recipe on Latin reports that in one bottle, the means contains cefazolin without impurities of additional components.
Clinical and Pharmacological Group: Cephalosporin I generation.
What does cefazoline help from?
According to the instructions, the use of cefazoline is shown in the following infectious diseases:
- infections of soft tissues;
- skin infections;
- infections of the bone-articular apparatus;
- pneumonia, the abscess of the lungs, Empiama of the pleura;
- peritonitis, endocarditis, osteomyelitis of burn, wound infections;
- infectious inflammatory processes in the urinary tract.
Presented drug is often assigned to postoperative period And in this case, it is a preventive preparation to prevent complications.
pharmachologic effect
Cephazoline has a wide range of antimicrobial (bactericidal) action.
Active with respect to gram-positive microorganisms (Staphylococcus SPP., Forming and not forming penicillinase, most Streptococcus SPP strains., Including pneumococci, CorineBacterium Dlphtheriae), gram-negative microorganisms (Escherichia coli, Salmonella SPP., Shiqella SPP., Proteus Mirabilis, Klebsiella SPP., Haemopnylus Influenzae, Enterobacter Aerogenes, Neisseria Gonorrhoeae).
The cefazoline is resistant to indoleplate strains Proteus SPP., Mycobacterium tuberculosis, Pseudomonas Aeruginosa, anaerobic bacteria.
Instructions for use
When the cefasoline injections are prescribed, the application instruction reports that dosages and the duration of the course may be different depending on the disease and the individual sensitivity of patients. Usually the course of treatment lasts from 7 to 14 days. It is impossible to use cefasoline injections less than 5 or more than 15 days, since in this case there is a high risk of developing microorganisms resistant to antibiotic.
- Preparation of solutions for injection and infusion: 0.5 g of preparation is dissolved in 2 ml of water for injection (can be used in the case of intramuscular administration of the preparation of novocaine to reduce soreness at the injection site), 1 g - in 4 ml of water for injection.
- For intravenous bolus administration, the resulting solution is diluted with 5 ml of water for injections, then injected slowly for 3-5 minutes. For in / in drip administration, the drug is breeding 50-100 ml of 5% or 10% dextrose solution, 0.9% solution of sodium chloride, ringer solution, 5% sodium solution of bicarbonate.
Daily dose of antibiotic for adults - from 1000mg to 4000mg. The daily dose depends on the sensitivity of the pathogen to the drug, as well as from the severity of infection. A single dose of the drug for adults with infectious-inflammatory processes caused by gram-positive microbes is 250-500 mg every eight hours.
Contraindications
It is impossible to use the drug in such cases:
- Pregnancy and breastfeeding period;
- The simultaneous use of cefazoline with "loop" diuretic drugs;
- Individual intolerance to the drug and its components;
- Age of patients, less than 1 month of life;
- Increased sensitivity to cefassoline and its components.
Also unacceptably the simultaneous finding of the medicine in one syringe with other antibacterial drugs.
Side effects
For side effects in the treatment of cefazolin include:
- From the side of blood formations: neutropenia, leukopenia, thrombocytopenia, thrombocytosis, anemia.
- From the sides of the digestive system: nausea, vomiting, diarrhea or constipation, meteorism, abdominal pain, dysbacteriosis, candidiasis of the gastrointestinal tract (including candidal stomatitis), violation of the liver function (increasing activity of hepatic transaminases, SHF, hyperbilirubinemium), rarely Stomatitis, Glossite, hepatitis and cholestatic jaundice, pseudomambranous enterocolitis.
- Allergic reactions: skin rash, urticaria, itching, bronchospasm, swelling of quinque, arthralgia (joint pain), exudative erythema.
- From the nervous system: convulsive syndrome.
- From the side of the urinary system: violation of the kidney function.
- Local reactions: pain in the injection site of cefazolin, phlebitis.
- With long-term therapy - dysbacteriosis, candidiasis.
According to Cefazolin reviews, when administered in doses, which exceed the recommended, causes paresthesia, dizziness, headache.
Analogs
The following cefazolin analogues are known:
- Cefaazex;
- Cefasoline Astrafarm;
- Cefazolin AKOS;
- Reflin;
- Cesiline;
- Cephazolin-Farmex;
- Cefhamesein.
ATTENTION: The use of analogs should be coordinated with the doctor.
Latin name: Cefazolinum
ATH code: J01DB04.
Active substance: Cefasoline
Manufacturer: Biochemist, Synesez, Russia
Pharmacy vacation condition: On prescription
Cephazolin - antibiotic antimicrobial action aimed at eliminating all sorts of infections and sensitive to the main active substance of similar diseases.
Indications for use
Cephazoline (cefazolin-AKOS) is used to eliminate various inflammatory infections and similar diseases, if those are sensitive to it. Among them:
- Endocarditis
- Sepsis
- Peritonitis
- Various urinary tract infections
- A variety of respiratory tract infections
- Infections associated with bones and joints.
With angina, flu, cold and other seasonal diseases This drug does not apply
The composition of the drug
In the powder filled with a bottle of cefazolin (cefazoline-AKOS) contains 1 mg of the active substance for injection - cefazolin.
Medical properties
Cephazolin (cefazolin-AKOS) is an antimicrobial injection drug or for drip administration therapeutic effects A fairly wide range of infectious diseases. Its active substance is cefazoline - reaches such an effect with the help of the inhibition of the synthesis of various substances of the cell wall. It is the latter that contributes to the destruction of the microbial cell and subsequently the complete cessation of the inflammatory process.
After the injection of Cephazolin begins to act in an hour, but after 12 hours therapeutic effect It comes off. Cefasoline is excreted through the work of the kidneys, with urine, and mainly unchanged.
Form release
Average price - 40 rubles
Cephazoline (cefazolin-AKOS) is produced in bottles of 0.5, 1 and 2 g. On the view - white powder, which needs to be breeding for injection or for drip administration. No other form of release in the drug, except for the white powder for injection, no.
Mode of application
Preparation of solution
There are three main ways to dissolve cefazoline that doctors tend to describe in recipes:
- Dissolve powder in 5 ml of special fluid (for intramuscular administration, injection)
- Dissolve, but only using 10 ml of liquid (for intravenous administration)
- Dissolve 0.5 or 1 mg of the drug in 100-250 ml of liquid (for drip administration)
And how to breed cefazoline with Novokain, if the doctor prescribed? First, you need to purchase 2% novocaine or lidocaine. After that, you need to cook sterile syringes and follow the instructions:
- Open the ampoule with Novocaine or with Lidokain
- Prepare a syringe, omit it into the ampoule and capture the desired number of novocaine (lidocaine), and then remove the syringe
- Open the bottle with cephazoline powder, pierce the needle rubber lid and gently, slowly squeeze novocaine or lidocaine into the vial
- Not a touching syringe, shake the bottle in order for everything to dissolve everything, and then score the required volume of the resulting solution
- And after making an injection of novocaine or lidocaine solution (conduct an injection).
Application
- With medium and easy degrees of infectious diseases, the child, for three or four receptions, divided for several days, injections are made to 20-50 mg of medication for each kg of its weight
- With heavy - 100 mg.
Adult:
- In case of infections of the urogenital system and with infectious diseases of the respiratory tract of moderate severity, the dose recommended by an adult - 0.5 or 1 g of the drug every 12 hours
- Dose with the same respiratory infections, but already in severe form - 1-10 mg of antibiotic per day, take every 8 hours
- For diseases that were caused by gram-positive pathogenic microflora, take 0.25-0.5 g of the drug every 8 hours
- If the opposite is gram-negative, then 0.5-1 g of antibiotic every 6-8 hours.
During pregnancy and breastfeeding
As a rule, antibiotics during pregnancy are used only as forced measures when they can no longer do without them. It is worth remembering that in the first trimester they are contraindicated in general, and in after this period they can be appointed only by an experienced doctor, and only after a careful examination of the patient and the conclusion of its health. The use of cefazoline during pregnancy in the form of injections and as an antibiotic does not go beyond this rule.
If treatment is needed with breastfeeding, then breastfeeding is completely canceled. Cephazolin quickly penetrates the maternal milk, and therefore feeding can entail unpleasant consequences.
Contraindications
Use cefazoline (cefazolin-acos) is prohibited in cases:
- If the patient has allergies or intolerances of substances in the preparation
- If the patient's age is less than one month; Cefasoline children of another age is not contraindicated.
Precautions
If the patient has kidney disease, then Cephazolin (cefazolin-AKOS) is accepted in small doses prescribed to prevent the accumulation of the substance. It is not recommended to make injections with antibiotic people who have allergic reactions. But if you take this medicine is necessary, the doctor may appoint a course of treatment with anti-allergic drugs and only then prescribe a drug in small doses to the patient.
It should also be aware that after injection cefazoline, it is very easy to penetrate into the okolosovic liquid at the site of inflammation and through the protective barriers of the brain, why in patients and there are various side effects.
Interaction with other medicines
If we jointly use the antibiotic cefazoline (cefasoline-acos) with some drugs, then different reactions may appear. So, if you simultaneously use the antibiotic and antibacterial drugs of the penicillin group, unpleasant allergic reactions may appear. If you take a probe, then the withdrawal of the cefassoline substance will slow down.
In addition, it is worth noting that cefazoline and alcohol - things are completely incompatible. Even after use ethyl alcoholcontained in some drugs (what to talk about the use of alcoholic beverages), complications are developing, very similar to the side effects of disulfiram. Usually liver diseases.
Side effects
After applying this drug, some side effects of the following character may occur:
- Pain in the abdomen
- Nausea
- Vomot
- Diarrhea, diarrhea
- Glossitis
- Heartburn
- Loss of appetite
- Violation of the functional activity of the kidney
- Candidiasis.
About how to quickly eliminate heartburn, read in the article:
Also, some patients feel pain after injuries by an antibiotic and discover the seal at the site of intramuscular injection, which is not really anything. A variety of allergic reactions to cefazoline (Cephazolin-AKOS) were recorded, among which: urticaria, anaphylactic shock, vascular pains, skin rashes and itching in various places, feverish states, an increase in the volume of eosinophilic leukocytes and Otchal Qink.
It rarely rarely, but still there were side effects directly related to the blood system - a decrease in quantity and platelets, and leukocytes, and blood neutrophils. It does not bring much harm, since such a decrease in the number of cells is reversible and stops immediately after the cessation of treatment with the drug. Blood at the same time acquires its usual, normal composition.
Overdose
Overdose after improper use of cefazoline antibiotic (cefazoline-acos) is permissible and it is manifested by a number of symptoms, such as:
- Inpropant muscular abbreviations
- Convulsive syndrome
- Headaches
- Dizziness
- Presthesia
- Sudden heart rhythm disturbances
- Vomiting.
The treatment of these symptoms is as follows: first, you need to immediately stop putting injections by the drug, secondly, if the symptoms are too disturbed by the patient, he needs to start taking medicines that can eliminate them. It was noted that the body itself contributes to the withdrawal of an antibiotic - hemodialysis is accelerated during overdose, which contributes to the speedy completion of the entire process. Well, if the case is very hard, then there is hospitalization and mechanical cleaning of blood is applied - dialysis.
Conditions and shelf life
Analogs
Cephazolin Sandos
Sandoz GmbH, Germany
Price About 70 rubles.
The main difference between Sandos from ordinary cefassoline or cefazolin-AKOS is that it is made in Germany. In the rest of the rest, in the composition, in the testimony and contraindications, in side effects - these injections do not have differences. The drug is produced in the form of the same white powder, but in another package. Only the price is higher, which is not observed in the domestic counterpart.
Also, according to patients, cefazoline Sandoz is very painful, so it is recommended to breed it with novocaine or lidocaine.
Pros:
- Produced in Germany
- Availability literally in all pharmacies.
Minuses:
- Higher price
- "Bible" injections.
Ceftriaxon
Lekchenko, Russia
Price About 30 rubles.
Ceftriaxone is a drug that is applied with the same diseases listed and is also introduced intravenously or intraight. The main difference between Ceftriaxone from Cephazolin is the acting substance Ceftriaxone, which does not differ from the cefazolin in its action. Ceftriaxone can also be introduced to both children, adults, with care pregnant. Ceftriaxone also treats inflammatory infections, but not an angina with a cold, and when it is introduced, the same side effects may arise. And the patients who took ceftriaxone argue that he is stronger than cefazoline.
Pros:
- Stronger action.
Minuses:
- Shelf life - 2 years
Cefotaxim
Romed Exports, India
Price About 30 rubles.
Cefotaxim is another drug with the same testimony for use. The main difference between cefotaxim from the analogs is the existing substance Cefotaxim, in the rest, it looks like previous drugs. It is also impossible to prick cefotaxim intramuscularly to children up to 2.5 years.
Patients responded about the preparation for the most part well, many glad that the treatment passes quickly and without allergic reactions.
Pros:
- Fast improvement of the patient's condition
- In most cases, the absence of allergic reactions to the drug.
Minuses:
- Little shelf life - two years
- During pregnancy and at age less than 2.5 years, Cefotaxim is strictly prohibited.
Sulbactomax
Mili Healthcare Ltd, United Kingdom
Price About 270 rubles.
Sulbactomax is another analogue of cefazolin, which is also a powder for breeding. The drug is quite recently developed and is considered an innovative antibiotic due to the fact that it has two active substances in their composition: 1000 mg of ceftriaxone and 500 mg of sulbactam. So, due to this, it is effective against infections of soft tissues, lower respiratory tract, against meningitis and gonorrhea. Available for children. But there is a bad side in the innovation - this is a greater number of possible side effects, including an exam, shortness, jaundice, etc.
Pros:
- Treats more diseases (meningitis, gonorrhea, etc.)
- Available for children from infant age.
Minuses:
- More side effects
- Higher price.
Before proceeding with the treatment of "Cephazolin", acquainted with the instructions for use. Designed for injection in the injection method. The antibacterial agent "Cefazolin" is struggling with infections of different types.
The antibacterial drug has a type of powder. In the future, designed for breeding. The composition is in glass bottles (not ampoules) with a hermetic lid. Active Component - Cefazolin sodium salt. The glass container contains 500 mg or 1 g of the mixture.
The color of the mixture, depending on the party, can change. White times drops yellow tint. Basic characteristic - hygroscopicity. Cefazolin-AKOS differs from Cefazolin solely by the title and manufacturer. It has the same medicinal composition.
Pharmacological effect of the drug
The medicine refers to the cephalosporin antibacterial preparations of the first generation. Based on the powder, a solution is prepared, which is introduced into the human body by the parenteral method. Since it is considered a beta-lactam antibiotic, characterized by an antibacterial effect. Prevents the synthesis of the cell wall of microorganisms.
Pharmacodynamics and pharmacokinetics medication
"Cefazolin", despite the density of tissues, easily penetrates inside, destroying pathogenic microorganisms. Thanks to this feature, there are many diseases. The active ingredient is allocated with breast milk During the feeding of the baby, as he penetrates the placenta. The minimum amount of diluted powder accumulates in intraocular and cerebrospinal fluids.
"Cefazolin" deprived of the ability to be metabolized and excluded, to a greater extent, with the help of kidneys. Part of the liquid leaves the human body along with bile.
Indications for the use of drug
"Cefazolin" is shown in many diseases affecting different organs in the human body. Therapy "Cefazolin" may be needed in the following cases:
- infectious damage to the lower and upper respiratory tract of a bacterial nature;
- pathology of the ENT system;
- damage to small pelvis;
- grocery therapy I. urinary tract;
- mastitis;
- peritonitis;
- infectious damage to soft tissues and skin.
Antibiotic in the form of injections is mandatory after operational treatment. Stabilizes the condition of a person as a result of injury, heavy burns and other diseases.
Instructions for the use of "Cefazolin" (method and dosage)
The drug is introduced into a vein or muscle. The required amount is dissolved by another medicine, which also prescribes the doctor. The setting of the dose depends on the degree of damage to the human body disease. In turn, it affects the frequency of drug administration.
Cooking for enclosures
Sterile water, "Lidocaine" or "Novocaine" is used to produce fluid. Injections of antibiotics are characterized by soreness. Therefore, it is recommended to breed the "lidocaine" or "novocain" powder, which are anesthetic. Prepared solution very easy:
- The liquid is gained into the syringe after opening the ampoule.
- With a flock with a powder, a seal is broken and, making a hole with a needle in the lid, fluid is introduced.
- Without removing the syringe, the bottle shakes until the solution inside becomes homogeneous.
If it is necessary to introduce intramuscularly, water, "Novocain" or "Lidocaine" is used. Intravenous administration involves the use of sterile water during the preparation of the solution. To reduce soreness, the drug is injected slowly. The average administration time varies from 3 to 5 minutes.
Antibiotic-based solution is prepared before the worst. About his quality says transparency. The liquid must be clean, without strangers, small particles, muta and not have a precipitate. If it is clean, but it has a yellow tint - this is the norm.
No preparation of fluid is allowed a few hours before administration. The solution should always be "fresh". In rare cases, you can store a ready mix for 2 days. It is better to keep it in the door of the refrigerator.
Features of the use of the drug depending on the disease
For adults, the antibiotic is applied as follows:
- Easy flow infection - the drug is injected twice a day. Dosing - from 500 mg to 1000 mg. In 24 hours, no more than 2 g of the active substance is introduced into the body.
- Infectious pathologies of an acute nature that are not accompanied by complications. Mandatory dose - 2 g, divided into introduction in the morning and in the evening.
- Inflammation of the lungs caused by the penetration into the organism of pneumococci. Dose per day - 1 g of drug. 500 mg are introduced in the morning, the rest is in the evening.
- Diseases of an infectious nature require the use of "cefazolin" every 6-8 hours. The recommended dose is 500 mg.
- For states that are accompanied by a heavy infectious process, 1 g of "Cefazolina" is introduced every 6 hours. Maximum daily dose Antibiotic is 6 g
In medicine it is allowed to introduce 12 g of the drug into the human body. At the same time, the question arises about the patient's life and death. Treatment should pass under the strict observation of the doctor. For the elderly, the dosage is no different if there is no contraindications to therapy.
The procedure for conducting injections
The intramuscular method of input is an injection in the shoulder, the thigh or the upper part of the buttocks. The most common place is the buttocks. If the "cefazoline" is appointed for intravenous administration, in addition to the injections, drippers are used.
"Cefazoline" divorces the dosage required for each particular person. If it is 500 mg, the corresponding bottle is taken. It is strictly forbidden to buy bottles of 1000 mg of the drug and divide them into 2 receptions. At the same time, to obtain a dose of 1000 mg, it is allowed to take 2 bottles of 500 mg of powder or 4 to 250 mg.
Features of use during pregnancy and lactation
As a rule, "cefazoline" is not prescribed at the time of having a child. But there are exceptions. At the same time consider the ratio of benefit for mother and harm to the body of the kid. If the first indicator significantly exceeds the second - the treatment of "cefazolin" is carried out.
During treatment with antibacterial drug, a slight amount penetrates into breast milk. At the time of therapy from feeding refuses. Freshing can be resumed after the end of the course of treatment.
Childcare
In such cases, the antibiotic is rarely applied. As a rule, these are situations in which the life of children is under threat.
If the treatment of "cefazolin" cannot be avoided, it is necessary to choose the maximum for the dose for the baby. The daily rate is divided into 3-4 receptions.
If the kidney or liver function is violated
In patients who have this diagnosis, treatment "cefazolin" is carried out. But the dosage can be reduced to values \u200b\u200bthat will not harm.
What happens when overdose
At the site of the introduction of the drug, the skin is inflamed, edema can appear. Patients often celebrate pain. Dizziness occurs. As a result of the introduction of the drug, convulsions may appear.
Side effects and contraindications
The negative impact on the body is accompanied by a failure in the work of all vital organs. The digestive system suffers. Disorders are observed in the functioning of the nervous system. A person becomes restless, weak and nervous.
Side effects are often manifested in the development of an allergic reaction. The skin is covered with characteristic rash. It becomes itching, burning and redness of individual sites.
Among the contraindications to use are distinguished:
- intolerance to individual components of the drug;
- children's age up to 1 month.
"Cefazoline" is allowed for use in people who suffer from kidney or liver failure. It is recommended to use with caution in patients with intestinal diseases.
Special instructions of antibiotic
Since "Cefasoline" is an antibiotic, a person cannot assign it for independent treatment. Therapy begins after examining the patient.
Interaction of antibiotic with other medicines
The drug is prohibited to be taken simultaneously with anticoagulants and diuretics. If the patient passes therapy when chronic disease, it is necessary to inform about this to the doctor. Knowing the history of the disease, the specialist will be able to choose a medicine that will be combined with other drugs.
Shelf life and storage conditions
The drug is suitable for use for 3 years from the date of production. If the shelf life has come out, it is prohibited. Otherwise, harm to health is possible.
Terms of sale and the cost of the drug
The antibacterial agent is released by the recipe. The cost is higher than the average. It is possible to buy bottles in the desired quantity (piece).
Analogues of "Cefazolina"
The drug preparation has many synonyms. Released under different names.
"Cefazolin Sandoz"
During the appointment of the antibiotic, the possibility of developing cross-reaction with other drugs included in the cephalosporins group is taken into account.
"Ceftriakson"
Assigns, as a rule, as a result of surgical operations.
"Cefotaxim"
During medicinal therapy is prohibited alcoholic beverages. "Cefotaxim" is not used to treat pregnant and nursing breasts.
Sulbaktomax
It is a combined drug. The composition has sulbactams and ceftriaxone.
All analogues have a common feature - the same active ingredient. If, when using "cefazolin" or one of its analogues, an allergic reaction is developed, the treatment is suspended. After the symptomatic patient's therapy, they again examine and select the drug that will not harm the body.
Photo of drug
Latin name: Cefazolin.
ATX code: j01db04
Active substance: Cefazolin (Cefazolin)
Manufacturer: CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd. (China), Serena Pharma Pvt. Ltd., M.J.BiPharm, Jodas Expoim Pvt. (India), Leko ZAO, Deco Company, Biosynthesis, Ruzfarma, Kraspharma, Pharmacenese OJSC (Russia), BelMEDPreparats RUE (Belarus)
Description Actual on: 24.10.17
Cephazoline is a cephalosporin antibiotic related to semi-synthetic antimicrobial drugs. It has a wide range of bactericidal action. The drug is active in terms of gram-negative and gram-positive pathogenic microorganisms.
Active substance
Cefazolin (Cefazolin).
Release form and composition
The drug is produced in the form of a powder for cooking injection solution lyophilized, white or almost white.
Indications for use
Effective in the following infectious diseases:
- chronic and acute bronchitis;
- abscess of lungs, pneumonia, empya pleura;
- endocarditis, peritonitis, osteomyelitis of wound and burn infections;
- infectious inflammatory processes in biliary tract;
- urinary tract infections;
- infections of the bone-articular apparatus;
- infectious diseases of the skin;
- infections of soft tissues;
- eye infections;
- syphilis, gonorrhea;
- infections after abortion;
- sepsis;
- uterine infection.
The use is also justified and as a prophylactic agent preventing the development of infections before and after surgical interventions when removing a gallbladder or uterine, joint operations, bones and hearts.
Contraindications
- hypersensitivity to drugs from the group of cephalosporins;
- breast-feeding;
- pregnancy;
- age up to 1 month.
Instructions for the use of cefazoline (method and dosage)
The drug is injected intravenously and intramuscularly, stingo and drip. The average daily dose for adults is 0.25-1 g, divided by 3-4 receptions. The maximum daily dose is usually 6 g, rarely 12 g. The rate is usually 7-10 days.
As a measure of prevention of postoperative complications, the antibiotic is administered intravenously 30-60 minutes before the operation, 0.5-1 g - during the intervention and 0.5-1 g every 8 hours during the first day after the operation.
If the kidney function is violated, the dose is adjusted in accordance with Creatinine clearance:
- at QC 55 ml / min and concentration of creatinine in a plasma 1.5 mg% is administered to a normal dose;
- with CC 54-35 ml / min and creatinine concentration of 1.6-3.0 mg%, the usual dose is introduced at an interval to 8 hours;
- with KK 34-11 ml / min and the concentration of creatinine 3.1-4.5 mg% is assigned 0.5 doses at intervals of 12 hours;
- with CC 10 ml / min and less and the concentration of creatinine is 4.6 mg% and more shown 0.5 ordinary doses every 18-24 hours.
Children from 1 month showing 25-50 mg per 1 kg of body weight per day. With severe flow of infection - 100 mg per 1 kg of body weight per day. The daily dose is divided into 3-4 receptions.
Children with impairment of kidney function, the dose is adjusted in accordance with Creatinine clearance:
- with CC 40-70 ml / min - 60% of the average daily dose with an interval of 12 hours;
- with CC 20-40 ml / min - 25% of the average daily dose with an interval of 12 hours;
- with CC 5-20 ml / min - 10% of the average daily dose every 24 hours.
Preparation of solution
0.5 g of preparation is bred in 2 ml of water for injection, 1 g - in 4 ml of water for injection. For intravenous bolus administration, the solution is bred in 5 ml of water for injections and introduced slowly for 3-5 minutes. For intravenous drip administration, the drug is divorced in 50-100 ml of 5% or 10% solution of dextrose, 0.9% solution of sodium chloride, ringer solution, sodium solution of bicarbonate.
When preparing a solution, the bottle is vigorously shaken until the preparation is completely dissolved.
Side effects
May cause the following side effects:
- From organs gastrointestinal tract: heartburn, loss of appetite, nausea, abdominal pain, glossite, diarrhea, vomiting. In rare cases, the development of pseudommabranous colitis and candidiasis is possible.
- From the urinary system: an increase in the concentration of urea and creatinine in the blood. When using an antibiotic in large doses, a violation of the functionality of the kidneys is possible.
- Allergic reactions: fever, itching, spasp of respiratory tract, skin rash, increase the number of eosinophils in the blood. In some cases, the development of angioedema edema, allergic nephritis, pain in joints, multiform exudative erythema or anaphylactic shock is possible.
From the side of the blood formation system, it is possible to reduce the number of leukocytes, neutrophils and blood platelets.
Also possible dysbacteriosis, dizziness, severity in chest, Candidiasis, cramps and accession of another infection.
Overdose
No information available.
Analogs
Analogs in the ATX code: Zolin, Iphizol, Cefol, Orpin, Cezolin, Cefezol.
Do not make a decision on replacing the drug yourself, consult your doctor.
pharmachologic effect
Cephazolin is the least toxic cephalosporin antibiotic with a wide range of action. It refers to semi-synthetic antimicrobial preparations from the Beta Lactam Group. This group of antibiotics kills pathogenic bacteria and microbes, destroying their cell walls.
Exhibits increased activity with respect to gram-positive and gram-negative microorganisms: staphylococci, diplococcus pneumonium, enterobacteria, intestinal sticks, salmonella, klebseyella, Schigella, Protesting, pathogen of the Siberian ulcers, hemophilic sticks, clostridy, treponym, spirochet, etc. The antibiotic does not work on mycobacterium tuberculosis, Sinnaya wand, fungi, viruses and simple microorganisms.
special instructions
- With anamnesis, burdened by allergic reactions to penicillins, an increased sensitivity to cephalosporin antibiotics is possible.
- Preparation with caution is prescribed for gastrointestinal diseases.
- Against the background of therapy, a positive direct and indirect Cumbac sample is possible, as well as a false positive reaction to glucose in the urine.
- The safety of applications in newborns and premature children is not installed.
During pregnancy and breastfeeding
Contraindicated during pregnancy and lactation.
In childhood
It is contraindicated for children to 1 month and prematurely due to the fact that the safety of the application in these groups of patients is not established.
In old age
No information available.
With violations of the kidney function
If the liver function is violated, the dosage is changing according to the instructions and QC indicators.
When violations of the liver function
Appointed with caution.
Medicinal interaction
- Reception with anticoagulants and diuretics are not recommended.
- Loop diuretics and drugs that block the tubular secretion increase the plasma concentrations of the drug.
- Aminoglycosides increase the risk of kidney damage.
- Cephazoline is pharmaceutically incompatible with aminoglycosides (mutual inactivation). To prepare a solution for in / in administration (inkjet or drip), it is impossible to use lidocaine.
