Bezylpenicillin - preparations (sodium salt, potassium salt, novocaine salt, benzatin benzylpenicillin, etc.), action, instructions for use (as dilution, dosages, methods of administration), analogues, reviews, price

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The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!

Bezylpenicillin is an antibiotic group penicillinsintended for injecting administration. The drug is used to treat various infections caused by bacteria sensitive to its action, such as, for example, pneumonia, bronchitis and other severe infectious diseases of the ENT organs and respiratory tract, meningitis, syphilis, endocarditis, purulent infections, etc.

Varieties, titles, composition, output and general characteristics

Benzylpenicillin is one of the oldest antibiotics Penicillin groups and, despite the long period of its use, has a wide range of action, killing a large number of varieties of pathogenic bacteria. For example, benzylpenicillin is effective against the causative agents of Siberian ulcers, syphilis, meningococci, gas gangrene, as well as many staphylococci and streptococci.

Since benzylpenicillin is practically not absorbed in the digestive tract, it is injected exclusively injectable. The most often solutions of the drug are injected intramuscularly or intravenously. However, in addition, the introduction of benzylpenicillin in the spinal channel (under meningitis), under the skin or directly to the wound region.

Benzylpenicilline is an antibiotic that contains the same active substance. However, in drugs, benzylpenicillin is not in pure form, but in the form of salts. Benzylпenicillin salts are stable and can be stored, unlike a pure active substance, which quickly disintegrates. In the body of salts, benzylpenicillin is released and the action is destructive on bacteria.

Depending on whether benzylpenicillin in the form of salt is located in a dosage preparation, the varieties of benzylpenicillin are distinguished. In principle, all varieties of benzylpenicillin are the same in its spectrum of action, but differ in the duration of the effect and methods of administration. Therefore, when various diseases It is recommended to select the type of preparation that is optimally suitable for the requirements of therapy.

Currently, the following varieties of benzylпenicillin are issued:

• Bezylpenicillin sodium salt ( trade names drugs - "benzylpenicillin sodium salt", "Novocin", Penicillin G);
• Benzylpenicillin potassium salt (trade name of drugs - "benzylpenicillin potassium salt");
• Benzylpenicillin novocaine salt (trade name of drugs - "benzylpenicillin novocaine salt");
• Benzylpenicillin plotovaya salt (trade name of drugs - "plot Penicillin");
• Benzatin benzylpenicillin (trade names of drugs - "Retarpen", extensingillin, bicillin-1, benzitinzylpenicillin, Moldamine);
• Bicyllin-5 (a mixture of benzatin and draft benzylpenicillin salts).

All indicated varieties of benzylpenicillin contain precisely benzylpenicillin in the form of various salts as the active substance. Dosage of any variety medicinal preparation It is indicated in the international unit) or units of the action of pure benzylpenicillin. Since the dosage for all varieties of the drug is universal, they can be easily compared with each other and, if necessary, to replace one to another.

All varieties of benzylpenicillin are produced in the only dosage form - Powder for the preparation of the solution for injections. The powder is placed in glass vials, clapped with rubber caps covered on top of aluminum dense foil. The bottles, in which the antibiotic powder are packaged, is called "penicillin" in everyday life.

Benzylpenicillin - preparations

Currently on the pharmaceutical market of the CIS countries there are the following drugscontaining active component Benzylpenicillin salts:

• Benzylpenicillin potassium salt;
• Benzylpenicillin sodium salt;
• Benzylpenicillin novocaine salt;
• Benztinzylpenicillin;
• Bicyllin-1 (benzatin benzylpenicillin);
• Bicyllin-3 (a mixture of benzatine, sodium and procinic salt benzylpenicillin);
• Bicyllin-5 (a mixture of benzatin and draft benzylpenicillin salts);
• Moldamine (benzatin benzylpenicillin);
• Novocin (benzylpenicillin sodium salt);
• Penicillin G (benzylpenicillin sodium salt);
• Penicillin plot (benzylpenicillin plotovaya salt);
• Retarpen (benzatin benzylpenicillin);
• Extensively (Benzatin benzylpenicillin).

Act

Benzylpenicilline has a destructive effect on wide spectrum Bacteria that are causative agents of infectious inflammatory diseases of various organs and systems. Benzylpenicillin disrupts the process of synthesis of the cell wall of bacteria, due to which their death occurs. However, the effect on the synthesis of cell wall components leads to the fact that the drug destroys only bacteria in the process of reproduction. And therefore for the complete destruction of the entire pool of microbes in the body, drugs penicillin row It is necessary to apply at least 5 days so that all bacteria switched to the reproduction stage.

Benzylpenicillin penetrates all organs and tissues, and therefore can be used to treat infectious diseases Various localization, if they are provoked sensitive to its actions by bacteria.

All varieties of benzylpenicillin are destructively affect the following types of pathogenic microorganisms:

• Gonococci (Neisseria Gonorrheae);
• Meningococci (Neisseria Meningitidis);
• Staphylococcis that do not produce penicillinase;
• Streptococci groups A, B, C, G, L and M;
• Enterococci;
• Alcaligenes Faecalis;
• Actinomycetes;
• Bacillus Anthracis;
• Clostridiae;
• Corynebacterium Diphtheriae;
• ErySipelothrix Insidosa;
• Fusobacterium Fusiforme;
• Leptospirae;
• Pasteurella Multocida;
• SPIRILLLIM MINUS;
• SpirocaetaEae (Syphilis, Frambezia, Lime Burreliosis, etc.);
• Streptobacillus moniliformis;
• Treponema Pallidum.

Indications for use

Sodium, potassium, novocaine and procainous salts of benzylпenicillin

Sodium, potassium, novocaine and plox salt benzylpenicillin are shown to use for the treatment of the following infectious inflammatory diseases of various organs and systems:

• Infectious diseases of the respiratory organs (pneumonia, pleurisy, empya pleura, bronchitis, etc.);
• Infectious diseases of the ENT organs (angina, scarletin, medium otitis, sinusitis, laryngitis, sinusitis, etc.);
• Infections of the organs of the urinary tract (gonorrhea, syphilis, cystitis, urethritis, adnexitis, salpingitis);
• Purulent infections of the eyes, mucous membranes, leather and bones (for example, Blennorya, blepharitis, dacryocystitis, mediastinite, osteomyelitis, phlegmon, face, wound infection, gas gangrene, etc.);
• Purulent meningitis or brain abscess;
• Sepsis or septicemia;
• Treatment of diseases caused by spirochetes, such as syphilis, firmbezia, pint, Siberian ulcers, etc.;
• Treatment of fever provoked by rat bite;
• Treatment of infections caused by clostrids, lestery and pastellary;
• Prevention and treatment of diphtheria;
• Prevention and treatment of complications of streptococcal infections, such as rheumatism, endocarditis and glomerulonephritis.

Preparations containing benzylпenicillin benzatin

Preparations containing benzylpenicillin benzatin are shown to use for the treatment of the following infectious diseases of various organs and systems:

• Long prevention of rheumatic recurrences;
• Syphilis;
• Yaws;
• Infections provoked by streptococci groups in, such as tonsillitis, scarletin, wound infections, face;
• Prevention of postoperative infections.

In general, the main difference between the preparations of benzatin benzylpenicillin from other salts of this substance is that they are optimal for long-term therapy, since they have a long action and therefore are recommended for treatment chronic diseases. All the remaining benzylpenicillin salts (potassium, sodium, novocaine and procaine) have a short-term action and therefore optimal for treatment acute infections.

Instructions for use

Rules for choosing a salt of benzylпenicillin

Novocaine, prinel, potassium and sodium salt benzylpenicillin optimal for the treatment of acute infections of any localization. Therefore, in the presence of an acute infectious and inflammatory process, any indicated benzylpenicillin salt should be chosen. However, it is necessary to remember that novocaine and procaine have a powerful allergenic effect, so people prone to allergic reactionsIt should be abandoned from the use of novocaine and procinic salts of benzylpenicillin.

Benzylpenicillin benzatin is optimal for the treatment of chronic infections and the prevention of various infectious complications. Therefore, drugs containing this salt should be used for long-term therapy of various chronic diseases.

With the use of benzylpenicillin in high dosages (above 20,000,000 units per day) For more than five days, it is necessary to control the concentration of blood electrolytes (potassium, calcium, sodium, chlorine), the function of the liver (asat, aloset, ukf, bilirubin, etc.) and Picture of blood (overall blood test with leukoformula).

People using benzylpenicillin may have a false-positive urine reaction on sugar.

In people suffering from diabetes, sucking the antibiotic in the blood of the muscle slow down, so the effect of the drug begins more slowly.

Since the use of benzylpenicillin can lead to the development of fungal infection, then against the background of treatment with an antibiotic, it is recommended to prevent preventive

• Instructions for the use of benzylпenicillin sodium salt
• The composition of the drug benzylпenicillin sodium salt
• Indications of the drug benzylпenicillin sodium salt
• Conditions for the storage of the drug of benzylpenicillin sodium salt
• Shelf life of the drug benzylпenicillin sodium salt

ATX code: Antimicrobial preparations for systemic use (j)\u003e Antimicrobial preparations for systemic use (J01)\u003e Beta-lactam antibiotics - penicillins (J01C)\u003e Penicillins sensitive to beta lactamases (J01CE)\u003e Benzylpenicillin (J01ce01)

Release form, composition and packaging

powder d / quotation. P-RA D / V / M Introduction 1 million wt: FL. 10 or 50 pcs.
Reg. No: 5115/01/10/15/16 of 24.08.2015 - existing

Powder for the preparation of the solution for in / m administration White color.

1000000 DF - Vials (10) - Cardboard packs.
1000000 units - bottle (50) - cardboard boxes.

Description of the medicinal preparation BenzylPenicillin sodium salt Created in 2012 on the basis of the instructions posted on the official website of the Ministry of Health of the Republic of Belarus. Renewal date: 07/16/2013

pharmachologic effect

Bactericidal antibiotic from a group of biosynthetic ("natural") penicillins. Inhibits the synthesis of the cell wall of microorganisms. Active in relation gram-positive pathogens:

• staphylococci (not forming penicillinase), streptococci, pneumococci, corenebacterium diphtheria, anaerobic spore-forming sticks, chopsticks of Siberian ulcers, Actinomyces SPP.;
• Gram-negative microorganisms: NEISSERIA GONORRHOEAE, NEISSERIA MENINGITIDIS, as well as in relation to spirochete. Not active in relation to most gram-negative bacteria, Rickettsius, viruses, simplest. To the action of drug sustainable penicillin-forming strains microorganisms. Credited in an acidic environment.

Bezylpenicillin can be used isolated, as well as in combination with other bactericidal antibiotics.

Pharmacokinetics

C MAX in blood plasma at a / m administration is achieved in 20-30 minutes. T 1/2 drug is 30-60 minutes, renal failure 4-10 h or more. Communication with plasma proteins is 60%. Penetrates organs, fabrics and biological fluids, except for liquor, eye tissues and prostate. With inflammation of meningeal shells, penetrates the hematostephalic barrier. Passes through the placenta and penetrates breast milk. Excreted by kidneys unchanged.

Indications for use

• bacterial infectionscaused by sensitive pathogens: a bruboral and focal pneumonia, empya pleura, bronchitis;
• sepsis, septic endocarditis (acute and subacute), peritonitis;
• meningitis;
• osteomyelitis;
• infectilation of the urogenital system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, Blennorya, Syphilis, Cervicitis), biliary tract (cholangitis, cholecystitis), wound infection, skin infection and soft tissues: Ryg, impetigo, secondary dermatosis;
• diphtheria;
• scarlet fever;
• anthrax;
• actinomycosis;
• ENT diseases, eye diseases.

Dosing mode

Dosage and duration of application depend on indications and severity clinical picture. Treatment must be continued within two days after disappearances clinical symptoms Diseases.

As a rule, daily dose for children under 12 years It is 50000 units / kg, for adults - 1000000-30000,000 units / day.

Premature children and newborns (WT approx. 3.5 kg): 30000-100000 U / kg / day.

Children up to 1 year (W to 10 kg): 30000-100000 U / kg / day.

Children from 1 to 12 years old (W from 10 to 38 kg): 30000 U / kg / day.

Adults (WT from 40 kg and above): 1000000-5000000 U / day.

Special dosage cases:

Sepsis caused by gram-negative pathogens (Escherichia Coli, Enterobacter Aerogenes, Alcaligenes Faecalis, Salmonella, Shigellae and Proteus Mirabilis:

• in the presence of sensitive microorganisms, adults receive 200,000,000-80000000 U / day.

Bacterial endocarditis: In the presence of sensitive microorganisms, adults are obtained by 10,000,000-80000000 units / day V / B in combination of 120-240 mg of gentamicin per day or 1-2 g of streptomycin per day in / m.

Meningitis: Due to the increased inclination to convulsive reactions, adults should not be prescribed a drug in doses exceeding 20000,000,000,000,000 units / day, and children are no more than 12000000 units / day.

Sick s streptococcal infection Treatment should be carried out at least 10 days.

Congenital syphilis: 50,000 U / kg / day for 10-14 days.

Diffeter prevention:

• 300000-600000 U / day.

Neurosofilis: 2400000 URS / SUT for 10-14 days in combination with probelecid.

Outragia uncomplicated gonorrhea: One-time dose for both men and women 4500,000 units.

Chronic complicated gonorrhea: Daily dose of 3000000 units for 5-7 days for both men and women.

Dissolve the contents of the vial in 5-8 ml of water for injection; Before use, shook well with the purpose of mixing; enter by deep in / m injecting into the upper-storey square of the jagged muscle or in the upper-elder field using the HochStetter method; for repeated administration change the place of injection.

Sodium benzylpenicillin salt for 500,000 cells 3-6 times / day.

In patients with severe degrees of hepatic and / or renal failure Preferably clarify one-time doses Or intervals between doses in creatinine clearance values.

Dosage based on creatinine clearance:

Side effects

From the gearbox:occasionally marked stomatitis and glossites. Nausea, vomiting. The diarrhea resulting during the appointment of antibiotics should cause alertness with respect to pseudommbranous colitis (the possibility of the appearance of stable microorganisms or fungi) and further treatment should be specific to the microorganism of the causative agent. When superinfection appears, appropriate measures should be taken.

Allergic:proper attention should be paid by-effects, namely, anaphylaxis, urticaria, fever, articular pain, angioedema, multiform erythene and exfoliative dermatitis.

Due to bacteriology in infections caused by endotoxin-producing bacteria, such as salmonells, leptospiirs or treponema (treatment for syphilis), Yarish-Gersheimer's reaction (Jarish Hersheimer) may be observed due to bacteriology.

Hematologic:hemolytic anemia, leukopenia, thrombocytopenia or eosinophilia.

Disruption of the pump function of myocardium.

Occasionally, at a previously existing nephropathy, albuminuria and hematuria may occur. Observed in some cases when the benzylpenicillin of Oliguria or Anururia is prescribed, usually pass 48 hours after the cessation of treatment. The diuresis can be restored with the appointment of a 10% solution of mannitol.

Contraindications for use

• cases of increased sensitivity to penicillin (including other β-lactam antibiotics);
• allergic reactions to Penicillin require immediate cessation of the introduction of the drug and carrying out the necessary therapeutic measures. In patients with increased sensitivity to cephalosporins there may be cross-reactions of hypersensitivity (5-10% of cases).

Carefully Appoint penicillin patients with allergies.

Banal infections do not require benzylpenicillin treatment.

Application with violations of liver function

In patients with a pronounced degree of liver failure, it is desirable to pick up one-time doses or intervals between doses individually (see "Dosing Mode").

Application with violations of the kidney function

In patients with a pronounced degree of renal failure, it is desirable to select one-time doses and intervals between doses individually (see the section "Dosing Mode").

Application in children

As a rule, the daily dose for children under 12 is 50,000 units / kg.

Premature children and newborns (WT approx. 3.5 kg):

• 30000-100000 U / kg / day.

Children up to 1 year (W to 10 kg):

• 30000-100000 U / kg / day.

Children from 1 to 12 years old (W from 10 to 38 kg):

• 30000 U / kg / day.

special instructions

In the development of allergic reactions, the benzylpenicillin treatment should be immediately discontinued, and, if necessary, assign symptomatic treatment.

It is necessary to observe precautions in the treatment of patients with cardiopathy, gapovolemia (with inflammation of the volume of circulating blood), epilepsy, nephropathy and liver pathology.

When appropriate in high doses for more than five days, research is recommended electrolyte balance, kidney, liver and hematological tests.

In patients receiving benzylpenicillin may be a false positive reaction of urine on sugar.

In patients with diabetes, there may be a delay in the suction of benzylpenicillin from intramuscular depot.

It is possible to use benzylpenicillin during pregnancy and lactation for the appointment of a doctor.

With long-term treatment with antibiotics should take into account the possibility of the emergence of resistant strains of microorganisms and fungi.

In the case of venereal diseases, if there is a suspicion of syphilis, before the start of treatment and subsequently, for at least 4 months, research should be conducted in a dark field and serological analyzes.

Medicinal interaction

Antacids, glucosamine, laxatives, food, aminoglycosides - slow down and reduce the absorption of benzylpenicillin sodium salt; Ascorbic acid increases absorption.

With simultaneous use with benzylpenicillin anti-inflammatory, anthealth and antipyretic drugs, especially indomethacin, phenylbutazone and salicylate, suppression can be observed according to the competitive type of removal mechanism. Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) have a synergistic effect; Bacteriostatic (including macrolides, chloramphenicol, lincoosamides, tetracyclines) - antagonistic. Benzylpenicillin sodium salt increases efficiency indirect anticoagulantov (suppressing the intestinal microflora, reduces the prothrombin index); Reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which a para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing "breakthrough" bleeding. Diuretics, Allopurinol, Kanalis secretion blockers, phenylbutazone, nonsteroidal anti-inflammatory drugs, reducing the tubular secretion, increase the concentration of benzylpenicillin sodium salt. Allopurinol Ply sharing Enhances the risk of developing allergic reactions (skin rash).

Benzylpenicillin sodium salt powder for cooking for intramuscular administration 500000 units, 1000000
Manufacturer: Synthesis Kurgan

Instructions for medical application Preparation:
Benzylpenicillin sodium salt powder for cooking for intramuscular administration 500000 units, 1000000

Pharmacotherapeutic Group:
Antibiotic, Penicillin

Conditions of vacation from pharmacies
According to the doctor's prescription.

Product Description, Instructions.

Registration number P N 003931/01

Trade name of the drug: benzylpenicillin sodium salt

International unpatient name: benzylpenicillin

Chemical name - (2S- (2alfa, 5alf, 6bet) (- 3,3-dimethyl-7-oxo-6 - ((phenylacetyl) amino (-4-TIA-1-AZA Bicyclo (3.2.0 (heptane-2 -cake acid (in the form of sodium salt).

Dosage form: Powder for preparing a solution for intramuscular administration

Ingredients: active substance: sodium salt benzylpenicillin - 500000 units and 1000000 units.

Description. White powder.

ATH code:

Pharmacological properties
Bactericidal antibiotic from a group of biosynthetic ("natural") penicillins. Inhibits the synthesis of the cell wall of microorganisms. Active in terms of gram-positive pathogens: staphylococci (non-forming penicillinase), streptococci, pneumococci, corinbacteria diphtheria, anaerobic spore-forming sticks, chopsticks of Siberian ulcers, Actinomyces SPP.; Gram-negative microorganisms: NEISSERIA GONORRHOEAE, NEISSERIA MENINGITIDIS, as well as in relation to spirochetes. Not active in respect of most gram-negative bacteria, rickettsies, viruses, simplest. The action of the drug is resistant to penicillin-forming strains of microorganisms. Credited in an acidic environment.
Pharmacokinetics: The maximum concentration in the blood plasma with intramuscular administration is achieved after 20-30 minutes. The half-life of the drug is 30-60 minutes, with renal failure of 4-10 h or more. Communication with plasma proteins is 60%. Penetrates organs, fabrics and biological fluids, except for liquor, eye tissues and prostate. With inflammation of meningeal shells, penetrates the hematostephalic barrier. It passes through the placenta and penetrates breast milk. Excreted by kidneys unchanged.

Indications for use
Bacterial infections caused by sensitive pathogens: Big and focal pneumonia, Empiama pleura, bronchitis; sepsis, septic endocarditis (acute and subacute), peritonitis; meningitis; osteomyelitis; Infectilation of the urogenital system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, Blennorya, Syphilis, Cervicitis), biliary tract (cholangitis, cholecystitis), wound infection, skin infection and soft tissues: Ryg, impetigo, secondary dermatosis; diphtheria; scarlet fever; anthrax; actinomycosis; ENT diseases, eye diseases.

Contraindications
Increased sensitivity (including other β-lactam antibiotics); epilepsy (for endolumbal administration);
With caution - pregnancy, lactation period, renal failure.

Method of application and dose
Benzylpenicillin sodium salt is injected intramuscularly, intravenously, subcutaneously, endoomumoral, intraterally.
Intravenously, endolumbomically administered only in hospital conditions!
With intramuscular I. intravenous administration one-time doses at average severe course Infections of the upper and lower airways, urinary and biliary tract, soft tissue infections, etc. are 2.5-5 million foods 4 times a day. In case of severe infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million units per day; With gas gangrene - up to 40-60 million units.
Daily dose for children under the age of 1 year - 500,000-100000 U / kg, older than 1 year -
50,000 U / kg; If necessary, 200,000-300000 units / kg, according to life indications - an increase of up to 500,000 units / kg. The multiplicity of administration is 4-6 times a day, intravenously - 1-2 times a day in combination with intramuscular injections.
For intravenous jet administration, a one-time dose (1-2 million units) is dissolved in 5-10 ml of sterile water for injection or 0.9% solution of sodium chloride and introduced slowly, for 3-5 minutes. For intravenous drip administration, 2-5 million units are divorced by 100-200 ml of 0.9% solution of chloride sodium or 5-10% dextrose solution and administered at a speed of 60-80 CAP / min. With drip administration to children as a solvent, 5-10% solution of dextrose (30-100 ml, depending on the dose and age) use (30-100 ml, depending on the dose and age).
Solutions are used immediately after preparation, not allowing other medicines to them.
The solution of the drug for intramuscular administration is prepared immediately before administration, adding 1-3 ml of water for injection to the contents of the vial of the vial for injection, 0.9% solution of sodium chloride isotonic or 0.5% novocaine solution. When the benzylpenicillin is dissolved in a novocaine solution, a benzylpenicillin novocaine salt is precipitated, which is not an obstacle to intramuscular administration of the drug. Intramuscularly drug is introduced deep into the muscle.
Subcutaneously benzylpenicillin sodium salt is used to glue infiltrates at a concentration of 100,000-200000 units in 1 ml of 0.25-0.5% novocaine solution.
Endolumboly administered with purulent diseases of the head and spinal cord and brain shells. Preparation preparation in sterile water for injections or a 0.9% solution of sodium chloride at the rate of 1000 units / ml. Before injection (depending on the level of ins-cranial pressure), be removed from the spinal channel 5-10 ml spinal fluid And it is added to the antibiotic solution in an equal ratio. They are introduced slowly (1 ml / min), usually once a day for 2-3 days, depending on the disease and severity of its flow, adults - 5000-10000 units, children - 2000-5000 units, then go to intravenous or intramuscular injections.
In force processes in the lungs, the solution of the drug intracherally is introduced (after thorough anesthesia of the ozo, larynx and trachea). Usually 100,000 units are used in 10 ml of 0.9% sodium chloride solution.
In the cavity (abdominal, pleural, etc.) a solution of benzylpenicillin sodium salt adults are administered at a concentration of 10,000-20000 units in 1 ml, children - 2000-5000 units of 1 ml. As a solvent, water for injection or isotonic solution of sodium chloride is used. The duration of treatment is 5-7 days later, with a subsequent transition to the Introduction.
With eye diseases ( acute conjunctivitis, ulcer cornea, goblennorya, etc.) sometimes prescribe eye dropscontaining 20-100 thousand units in 1 ml of 0.9% sodium solution chloride or distilled water. Enter 1-2 drops 6-8 times a day.
For ear drops Or the drops into the nose are used solutions containing 10-100 thousand units / ml.
The duration of the treatment of benzylpenicillin depending on the form and severity of the course of the disease - from 7-10 days to 2 months and more.

Side effect
Allergic reactions: hyperthermia, urticaria, skin rash, rash on mucous membranes, arthralgia, eosinophilia, angioedema edema, interstitial nephritis, bronchospasm; rare anaphylactic shock;
From side of cardio-vascular system: swelling, an increase in the volume of circulating blood, it is possible to reduce the pump function of myocardium;
With endolumbal administration - neurotoxic reactions: nausea, vomiting, increase reflex excitability, meningheal symptoms, cramps, coma.

Interaction with other medicines
Antacids, glucosamine, laxatives, food, aminoglycosides - slow down and reduce the absorption of benzylpenicillin sodium salt; Ascorbic acid increases absorption. Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) have a synergistic effect; Bacteriostatic (including macrolides, chloramphenicol, lincoosamides, tetracyclines) - antagonistic. Bezylpenicillin sodium salt increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the prothrombin index); Reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which a para-aminobenzoic acid is formed, ethinyl estradiol - the risk of developing "breakthrough" bleeding. Diuretics, Allopurinol, Kanalis secretion blockers, phenylbutazone, nonsteroidal anti-inflammatory drugs, reducing the tubular secretion, increase the concentration of benzylpenicillin sodium salt. Allopurinol with co-use increases the risk of developing allergic reactions (skin rash).

special instructions
Benzylпenicillin solutions for intramuscular administration are prepared by Tempore ex. If after 2-3 (maximum 5 days) after the start of the use of the effect of the effect, it is not noted, it is necessary to proceed to the use of other antibiotics or combination therapy.
In connection with the possibility of the development of fungal lesions, it is advisable for prolonged treatment with benzylpenicillin to prescribe vitamins of group B and vitamin C, and, if necessary, nystatin and levels. It must be borne in mind that the use of insufficient doses of the drug or too early cessation of treatment often leads to the emergence of resistant strains of pathogens.

Packaging
5,500,000 units and 10,000,000 units of active substance in vials with a capacity of 10 ml or 20 ml. 1, 5 or 10 bottles with instructions for use are placed in a pack of cardboard.
50 bottles are placed in a box of cardboard with 1-5 instructions for applying for supply to hospitals.

Storage conditions
List B. In dry at temperatures from 15 to 25 ºС, inaccessible for children.

Shelf life
3 years. Do not use the expiration date specified on the package.

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Bezylpenicillin sodium salt powder for the preparation of a solution for intramuscular administration 500000 units, 100,000,000 units supply:

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medical application

drug

BenzylPenicillin sodium salt

Tradename

BenzylPenicillin sodium salt

International non-proprietary title

Bezylpenicillin

Dosage form

Powder for making a solution for intramuscular administration 1000000

Composition for one bottle

active substance: benzylpenicillin sodium salt - 1000000

Description

White powder or white with a slightly yellowish tint of powder, inclined to a coming, forming a resistant suspension when the water is added.

Pharmacotherapeutic group

Antibacterial drugs for system use. Penicillins of penicillinase sensitive

PBX code J01S01

Pharmacological properties

Pharmacokinetics

The maximum concentration in the blood plasma with intramuscular administration is achieved after 20-30 minutes. The half-life of the drug is 30-60 minutes, with renal failure of 4-10 h or more. Communication with plasma proteins is 60%. Penetrates organs, fabrics and biological fluids, except for liquor, eye tissues and prostate. With inflammation of meningeal shells, penetrates the hematostephalic barrier. It passes through the placenta and penetrates breast milk. Excreted by kidneys unchanged.

Pharmacodynamics

Bactericidal antibiotic from a group of biosynthetic ("natural") penicillins. Inhibits the synthesis of the cell wall of microorganisms. Active in terms of gram-positive pathogens: staphylococci (non-repeating penicillinase), streptococci, pneumococci, corinbacteria diphtheria, anaerobic spore-forming sticks, chopsticks of Siberian ulcers, Actinomyces SPP.; Gram-negative microorganisms: NEISSERIA GONORRHOEAE, NEISSERIA MENINGITIDIS, as well as in relation to spirochetes.

Not active in relation to most gram-negative bacteria (including Pseudomonas Aeruginosa), Rickettsia SPP., Simplest. To the action of the drug is stable Staphylococcus SPP. Penicillinase producing.

Indications for use

Brewer and focal pneumonia, empya pleura, bronchitis

Sepsis, septic endocarditis (acute and subacute)

Peritonitis

Meningitis

Osteomyelitis

Pyelonephritis, Pelitis, Custitis, Ureretrite, Gonorrhea, Blennorye, Syphilis, Cervicitis

Cholecitis, cholecystitis

Wound infection

Ryg, Impochigo, Secondary infected dermatoses

Diphtheria

Scarlet fever

anthrax

Actinomycosis

Skimorit, Otit

Purulent conjunctivitis

Mode of application and dose

Benzylпenicillin sodium salt is injected intramuscularly. In case of intramuscular administration, one-time doses with a moderate course of the disease (infections of the upper and lower respiratory tract, urinary and biliary tract, soft tissue infections, etc.) is 250,000 - 500,000 cells 4-6 times a day. With a severe course of infections (sepsis, septic endocarditis, meningitis, etc.) - 10-20 million eg per day; With gas gangrene - up to 40-60 million units.

Daily dose for children under the age of 1 year - 50000 - 100,000 units / kg, older than 1 year - 50,000 U / kg; If necessary - 200,000 - 300000 U / kg, according to life indications - an increase of up to 500,000 units / kg. The multiplicity of administration is 4-6 times a day.

A solution of the drug for intramuscular administration is prepared immediately before administration, adding water for injection to the contents of the vial 1-3 ml for injection, 0.9% solution of chloride sodium or 0.5% solution (novocaine). When the benzylpenicillin is dissolved in the solution, the solution may be observed as a result of the formation of benzylpenicillin crystals skid, which is not an obstacle to intramuscular administration of the drug. The resulting solution is introduced deep into the muscle. The duration of treatment, depending on the severity of the disease - from 7 to 10 days.

Side effects

Violation of the pump function of myocardium, arrhythmias, cardiac arrest, chronic heart failure (because with the introduction of large doses, hypernatremia may occur)

Nausea, vomiting, stomatitis, glossite, liver function

Violation of kidney function

Anemia, leukopenia, thrombocytopenia

Increased reflex excitability, meningeal symptoms, cramps, coma

- allergic reactions: sometimes - hyperthermia, urticaria, skin rash, fever, chills, increased sweating, rash on mucous membranes, arthralgia, eosinophilia, angioedema, interstitial nephritis, bronchospasm, seldom -anaphylactic shock

- local reactions: soreness and sealing at the site of intramuscular administration

Dysbacteriosis, the development of superinfection (with long-term use)

Contraindications

Increased sensitivity to penicillin and to other ß-lactam antibiotics

Endoomumbal administration during epilepsy.

Medicinal interactions

Antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of benzylpenicillin sodium salt. Ascorbic acid with co-use increases the absorption of the benzylpenicillin sodium salt.

Bactericidal antibiotics (including cephalosporins, vancomycin, rifampicin, aminoglycosides) have a synergistic effect; Bacteriostatic (including macrolides, chloramphenicol, lincoosamides, tetracyclines) - antagonistic. Bezylpenicillin sodium salt increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the prothrombin index); Reduces the effectiveness of oral contraceptives, drugs, in the process of metabolism of which para-aminobenzoic acid is formed.

Diuretics, Allopurinol, Kanalis secretion blockers, phenylbutazone, nonsteroidal anti-inflammatory drugs, reducing the tubular secretion, increase the concentration of benzylpenicillin sodium salt.

Allopurinol increases the risk of developing allergic reactions (skin rash).

special instructions

Carefully: pregnancy, lactation period, allergic diseases (bronchial asthma, Polling), renal failure.

The drug solutions are prepared immediately before administration. If after 2-3 days (maximum 5 days) after the start of use of the effect of the effect, it is not noted, it is necessary to proceed to the use of other antibiotics or combination therapy. In connection with the possibility of the development of fungal lesions, it is advisable for long-term treatment with benzylpenicillin to assign vitamins of group B, and if necessary - antifungal drugs. It must be borne in mind that the use of insufficient doses of the drug or too early cessation of treatment often leads to the emergence of resistant strains of pathogens.

Pregnancy and lactation

The use of the drug during pregnancy is possible only when the alleged benefit for the mother exceeds the potential risk to the fetus. If it is necessary to prescribe the drug during the lactation, it is necessary to stop breastfeeding.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

During the introduction of the drug, caution should be taken when managing vehicles, mechanisms and when performing other potentially dangerous species Activities requiring increased concentration and speed of psychomotor reactions.

Overdose

Pharmacotherapeutic Group:

• Antimicrobial, antiparasitic and antihafts

Pharmacological properties:

Pharmacodynamics

Antibiotic group of biosynthetic penicillins. It has a bactericidal effect by inhibiting the synthesis of the cell wall of microorganisms.

Active in relation to gram-positive bacteria: Staphylococcus SPP., Streptococcus SPP. (including Streptococcus Pneumoniae), Corynebacterium Diphtheriae, Bacillus Anthracis; Gram-negative bacteria: NEISSERIA GONORRHOEAE, NEISSERIA MENINGITIDIS; anaerobic spore-forming sticks; as well as Actinomyces SPP., SpirocaetaEae.

The action of benzylpenicillin is stable Staphylococcus SPP strains., Producing penicillinase. Credited in an acidic environment.

The novocaine benzylpenicillin salt compared with the potassium and sodium salts is characterized by a greater duration of action.

Pharmacokinetics

After the introduction, the introduction is quickly absorbed from the injection site. Widely distributed in the tissues and body fluids. Benzylpenicillin penetrates well through a placental barrier, a BEB with inflammation of brain shells.

T 1/2 - 30 min. Displays with urine.

Indications for use:

Treatment of diseases caused by benzylpenicilline microorganisms: Brewing and focal pneumonia, Empiama pleura, sepsis, septicemia, peymain, acute and subacute septic endocarditis, meningitis, acute and chronic osteomyelitis, urinary and biliary tract infections, angina, purulent skin infections, soft tissues and mucous membranes, face, difftheria, scarletin, Siberian ulcer, actinomycosis, treatment of purulent-inflammatory diseases in obstetric and gynecological practice, ENT diseases, eye diseases, gonorrhea, Blennorya, Syphilis.

Refers to diseases:

• Angina
• Gonorrhea
• Diphtheria
• Infection
• Meningitis
• Osteomyelitis
• Pleurisy
• Pneumonia
• Rygin
• Sepsis
• Syphilis
• Scarlet fever
• Empiama
• Empiama pleura
• Endocarditis
• Ulcer

Contraindications:

Increased sensitivity to benzylpenicillin and other preparations from the penicillin group and cephalosporins. Endoomumbal administration is contraindicated with patients suffering from epilepsy.

Method of use and dose:

Individual. Enter in / m, in / in, p / k, endoomolumboral.

With the / m and in / in the introduction of adults, the daily dose varies from 250,000 to 60 million units. The daily dose for children under the age of 1 is 50,000-100,000 units / kg, older than 1 year - 50,000 units / kg; if necessary daily dose It is possible to increase to 200,000-300,000 units / kg, according to life indications - up to 500,000 units / kg. Multiplicity of introduction 4-6 times / day.

Endolumboly administered depending on the disease and severity of the flow of adults - 5000-10,000 units, children - 2000-5000 units. The drug is bred in sterile water for injections or at a 0.9% solution of sodium chloride at the rate of 1 thousand s / ml. Before injection (depending on the level of intracranial pressure), 5-10 ml of SMF are removed and it is added to an antibiotic solution in an equal ratio.

P / K benzylpenicillin is used to slip infiltrates (100,000-200,000 units per 1 ml of 0.25% -0.5% of the novel solution).

Benzylpenicillin potassium salt is used only in / m and p / k, in the same doses as benzylpenicillin sodium salt.

Benzylpenicilline Novocaine salt apply only in / m. Average therapeutic dose for adults: one-time - 300,000 units, daily - 600,000 units. Children under the age of 1 year - 50,000-100,000 units / kg / day, older than 1 year - 50,000 units / kg / day. The multiplicity of introduction is 3-4 times / day.

The duration of the treatment with benzylpenicillin, depending on the shape and severity of the course of the disease, can be from 7-10 days to 2 months or more.

Side effect:

From side digestive system: Diarrhea, nausea, vomiting.

Effects due to chemotherapeutic effects: Candidiasis of the vagina, cavity candidiasis.

From the CNS: With the use of benzylpenicillin in high doses, especially in the endolumbal administration, the development of neurotoxic reactions is possible: nausea, vomiting, increasing reflex excitability, symptoms of meningism, convulsions, coma.

Allergic reactions: Increase body temperature, urticaria, skin rash, rash on mucous membranes, joint pain, eosinophilia, angioedema edema. Cases of anaphylactic shock with fatal outcome are described.

Application in pregnancy and breastfeeding:

Application during pregnancy is possible only when the intended benefit of therapy for the mother exceeds the potential risk to the fetus.

If you need to use during the lactation period, it is necessary to resolve the issue of cessation of breastfeeding.

Interaction with other drugs:

The probilecid reduces the tubular secretion of benzylpenicillin, as a result, the concentration of the latter in the blood plasma increases, the half-life increases.

With simultaneous use with antibiotics that have a bacteriostatic effect (tetracycline), the bactericidal effect of benzylpenicillin decreases.

Special instructions and precautions:

Caution is used in patients with impaired kidney function, with heart failure, predisposition to allergic reactions (especially during drug allergies), with increased sensitivity to cephalosporins (due to the possibility of developing cross-allergies).

If after 3-5 days after the start of the use of the effect, it is not noted, it is necessary to proceed to the use of other antibiotics or combined therapy.

In connection with the possibility of the development of fungal superinfection, it is advisable in the treatment of benzylpenicillin to prescribe antifungal drugs.

It is necessary to take into account that the use of benzylpenicillin in subterapeutic doses or early cessation of treatment often leads to the emergence of resistant strains of pathogens.

With violations of the kidney function

Caution is used in patients with impaired kidney function.