Cardiomagnyl is a combination of aspirin and magnesium hydroxide. Acetylsalicylic acid belongs to non-steroidal anti-inflammatory drugs. The benefits and harms of these substances to the body depend on the availability of indications and the individual tendency to characteristic side effects.

This group unites numerous chemicals that act in the same way on the body. They are used to reduce fever, pain, swelling and inflammation. There are many misconceptions around aspirin. Often, such drugs are taken for a long time, and they are attributed to non-existent side effects and sometimes real contraindications are underestimated.

Drug to reduce the risk of heart disease

Aspirin and cardiomagnyl, in particular, are recommended for the prevention of cardiovascular diseases. vascular system accompanied by an increased risk of blood clots. Such diseases include myocardial infarction, ischemic strokes and other complications.

Aspirin has a pronounced antiplatelet ability, that is, it prevents the formation of a blood clot.

After the discovery of such properties, the widespread use of the drug in low dosages for the prevention of thrombosis began. Elderly people and those prone to the development of heart and vascular diseases are prescribed daily intake of aspirin or cardiomagnyl preparations. The doctor preliminarily evaluates the patient's state of health, indications and possible risks and determines the appropriate dosage of the drug.

Precautionary measures

It is not uncommon for people to decide on their own to drink aspirin in small doses. But this does not mean that such a drug intake is safe, since the person himself cannot determine the indications for use. Therefore, it is recommended to see a doctor first. Often it is necessary to cancel the drug, since there are no indications for taking it, and contraindications are found.

What is the danger of uncontrolled intake of aspirin - the main active ingredient of the drug cardiomagnet? Its overdose is fraught with external and internal bleeding.

A serious danger of an overdose of aspirin is a rupture of cerebral vessels and the development of a hemorrhagic stroke, leading to the death of the victim, paralysis of one side of the body, or complete immobility of the patient.

Cardiomagnet - side effects

As it turned out, taking cardiomagnyl is not entirely safe. It would seem that the use of such small doses of aspirin drugs cannot be harmful. Especially when you consider its effectiveness and ability to prevent serious diseases.

However, taking many drugs is accompanied by one or another amount undesirable consequences... Cardiomagnum is no exception. Side effects with prolonged use of tablets, they are most often manifested in the formation of stomach ulcers and bleeding in the affected area of ​​the mucous membrane. Even small doses of aspirin increase the risk of ulceration by 2-3 times.

Of course, the increased likelihood of damage to the gastric mucosa should not stop the use of aspirin preparations. It is enough to increase attention to health and regularly consult a doctor to prevent illness. When the first symptoms are detected, it is much easier to stop pathological processes and restore the health of the mucous membrane of the upper sections gastrointestinal tract... The recommended doses in the range of 75-150 mg very rarely lead to an overdose of aspirin if the frequency of administration and the instructions for the drug are observed.

Contraindications to taking the drug: gastritis, long pregnancy, hepatitis, liver disease. In any case, only a local doctor has the right to prescribe cardiomagnet and decide how long to take it. Particular attention should be paid to pregnant women in order to exclude the harmful effects of aspirin on the child. In case of problems with increased blood clotting, the doctor may prescribe other approved drugs, which allows you to replace aspirin-containing drugs.

It is forbidden for pregnant women to start taking any medications on their own due to the dangerously high risk of intrauterine death of the baby!

Other side effects of taking aspirin medications include:

1. Cardiomagnum is able to provide some help in case of problems with potency. Improving the rheological properties of blood and its fluidity increases the blood supply to the tissues of the cavernous bodies of the penis and improves erection.
2. Aspirin has an inhibitory effect and helps to reduce the reaction. It is recommended to show caution to drivers and workers of hazardous industries.
3. Another negative consequence is coughing. However, such a symptom is nothing compared to the ability to avoid premature death.

The mechanism of ulceration

Aspirin does not act directly on the stomach wall. Side effects occur only after absorption into the bloodstream. Aspirin affects the secretion of certain enzymes that regulate the amount of substances that protect the walls from damage. These substances affect epithelialization, the secretion of the required amount of mucus and other components to prevent dystrophic changes in the gastric mucosa from the influence of hydrochloric acid. Therefore, acetylsalicylic acid itself is not able to have a significant effect on the walls of the stomach.

Considering the systemic effect on the mechanism of ulceration, coating with a special shell, the addition of buffer antacids is just a marketing ploy and luring potential consumers.

Reception of cardiomagnyl is convenient and is recommended for most people for prophylaxis. However, not everyone has access to its regular purchase. Pensioners often face this problem. Therefore, it is permissible to use ordinary cheap aspirin instead of an expensive drug. Such tablets are not coated and are in no way inferior to expensive drugs, and the price allows them to be used for a long time.

For effective prevention, it is enough to divide an ordinary acetyl tablet salicylic acid into quarters and take one part daily.

To prevent serious problems, it is worth taking care of your heart health beforehand. For men, this time comes at the age of 40, for women - after 50. It is believed that natural estrogens protect the heart from the development of disorders, and only with the onset of menopause, the female sex is deprived of this protection.

• smoking;
• overweight;
• sedentary lifestyle;
• depressive conditions.

Elimination of risk factors makes it possible to facilitate the functioning of the heart and blood vessels and stabilize the work nervous system... Dosed dosages work well for heart training. physical exercise moderate intensity. The greatest benefits are provided by cardio training: walking, swimming, jogging, cycling, Nordic walking. Power loads do not have a positive effect on the CCC.

With age, you should be more careful about nutrition and choose the right foods. It is recommended to reduce the consumption of fatty foods, flour and sweets.

Adding fatty fish to the diet will have a positive effect on vascular health and help reduce elevated level cholesterol.

Eating a lot of vegetables stabilizes bowel function and provides the body with the necessary amount of nutrients. The emphasis should be on plant-based foods high in potassium.

After the examination, the cardiologist may prescribe medications to reduce cardiac afterload, improve blood flow and myocardial nutrition. These drugs help blood flow from the heart to the periphery. Sometimes the consequence of vasodilation after taking drugs is headaches. Concomitant use of validol helps to improve well-being. The specialist will also determine if the intake of cardiomagnyl could be harmful to the health of a particular patient.

The doctor prescribed Cardiomagnet. The fact is that my doctor is on vacation, she is being replaced by a very young and always frightened, and stray from everything doctor. The results of a blood clotting test came back, some indicators are slightly exceeded. Appoints Cardiomagnet. My husband buys, I read the instructions and the desire to drink it disappears by itself! Read for yourself:

Contraindications to the use of the drug KARDIOMAGNIL
- I and III trimesters of pregnancy;

Application during pregnancy and lactation:
Contraindicated in the last (III) trimester of pregnancy, during the first 6 months (I and II trimester) - only under the supervision of a doctor... In the last trimester of pregnancy, even with a single dose, acetylsalicylic acid can affect the health of the unborn child, in particular, the vascular system and kidney function.
During lactation, prescribe with caution, acetylsalicylic acid penetrates into breast milk... When taking more than 300 mg per day breast-feeding should stop.

Only under the supervision of a physician. And here we are not talking about control.

Source http://m.baby.ru/blogs/post/13004622-6750003/

Forms of issue

Cardiomagnet instruction

Cardiomagnet is a combined antiplatelet drug used mainly not in medicinal, but in preventive purposes for the prevention of cardiovascular diseases associated with circulatory failure due to deterioration of the rheological characteristics of the blood. This is not the first cardiological drug of the pharmaceutical holding Nycomed, well-known in Europe (in Russia, the same concor is well known), but it is definitely one of the best-selling. The preparation contains two pharmacologically active substances: acetylsalicylic acid and magnesium hydroxide. A lot has been written about acetylsalicylic acid to date: its mechanism of action is based on the irreversible suppression of the activity of the enzyme cyclooxygenase-1, which, in turn, inhibits the synthesis of thromboxane A2 (a mediator that activates platelet aggregation). Meanwhile, pharmacologists attribute to acetylsalicylic acid and other properties aimed at suppressing platelet aggregation, which makes it a universal remedy for various cardiovascular diseases. In addition to this, acetylsalicylic acid has analgesic, antipyretic and anti-inflammatory effects. Magnesium hydroxide is introduced into the composition of cardiomagnyl in order to protect the mucous membrane of the digestive tract from the effects of acetylsalicylic acid. At the same time, the doses of magnesium hydroxide used do not reduce its bioavailability.

Despite the over-the-counter procedure for dispensing cardiomagnyl, its reception must be agreed with the doctor without fail, because otherwise, you can provoke the development of a number of undesirable side effects associated with the pharmacological action of the drug. We can say that these negative reactions are a continuation of the advantages of acetylsalicylic acid: for example, while taking the drug, bleeding may occur. varying degrees intensity, and if the patient takes anticoagulants or thrombolytics at the same time, then the risk of bleeding becomes even higher. Do not combine the intake of cardiomagnyl with alcohol: the drug itself can negatively affect the mucous membrane of the gastrointestinal tract, and strong drinks can significantly increase its risk of damage.

Cardiomagnyl tablets should be taken whole, but if the patient has problems swallowing, it is allowed to chew or break the tablet. In the prevention of thrombosis and acute coronary insufficiency in the presence of such aggravating factors as hypertension, overweight, diabetes mellitus, smoking, elderly age, it is recommended to take 150 mg of cardiomagnyl on the first day, and then 75 mg daily. For the prevention of heart attacks, the same dosages of cardiomagnyl are used.

Source http://protabletky.ru/cardiomagnyl/

Release form: Tablets

Alexandra (negative review)

Brought to the hospital bed!

I am a VSD with experience, and either against the background of VSD, or simply because of age, over the years appeared atrial fibrillation... Attacks are a very unpleasant thing, the heart pounds like crazy, the rhythm jumps, and it seems that you are about to die. Especially in spring and autumn they torment. The local cardiologist prescribed a drink of Cardiomagnet to support the heart. Drink, she said, until you get better. The price is unreasonably high: a jar of 100 tablets is 400 rubles, and their composition is the most common: acetylsalicylic acid, simply aspirin, and magnesium, which supposedly protects the stomach from the harmful effects of aspirin. There is a whole list of contraindications and side effects of this "Cardiomagnet". The pills only look funny, in the shape of hearts. I drank one a day, a couple of months. But then a strange weakness, dizziness appeared, the pressure dropped dramatically / I didn't even think about the pills. And one day, she fainted altogether, fortunately, that the case was at home, and her husband immediately called an ambulance. They took me to the hospital, and it turned out to be gastrointestinal bleeding, provoked by a long intake of Cardiomagnyl, that is, aspirin. It's good that they came out, the pills were canceled, of course. I will not recommend it to anyone, every second person has a weak stomach, and this Cardiomagnet can easily lead to a hospital bed.

Glad (positive feedback)

If you take it correctly, you will only get the benefit!

During the medical examination, it turned out that I had increased blood clotting - the platelet count in my blood was off the charts. And that means. that I have an increased risk of blood clots, therefore, heart attack and stroke in the future. They prescribed me Cardiomagnet, I thought it was something special, but it turned out that it was just aspirin and magnesium. That is why it is called "heart aspirin" - magnesium is needed for heart health. The drug is inexpensive, about 120 rubles. I drank only a pill at night, so it’s enough for a month - very profitable. In no case do not drink before meals, this is acid, and, of course, the gastric mucosa eats away, so ulcers and people with gastritis should not be used. Even I had a hard time - a very strong heartburn appeared, therefore I advise you to eat very densely, fatty before taking it - then the stomach will be protected. About the effect. In two months, my platelet level was completely back to normal - the effect is quick and strong. But when the main problem is eliminated, do not quit drinking, if you have a predisposition to thrombosis, if you are at risk (diabetes, obesity, hypertension - like mine), the effect will be temporary if you drink and quit. It is necessary to drink Cardiomagnet constantly, but with a dose adjustment. Many people complain about side effects, so I'll tell you what: drink the minimum dose that is possible to maintain a normal state, and you will not have any problems - if there are no contraindications. I began to drink only half of the pill, and I have no bleeding, gastritis or ulcers, although I have been drinking for six months already. So just be smarter and you will only benefit from the drug.

Source http://lekotzyvy.com/preparat/k/kardiomagnil/

Cardiomagnet is a drug from the group of antiplatelet agents (i.e., it reduces the level of thrombus formation, preventing the development of heart attacks and ischemic strokes). Kadiomagnil is acetylsalicylic acid in combination with magnesium hydroxide, which reduces damage to the stomach lining.

Antiplatelet agents, incl. Cardiomagnet, - an obligatory element of the treatment and prevention of diseases associated with thrombosis and blockage of blood vessels by detached blood clots. Cardiomagnet is prescribed for patients at risk of acute myocardial infarction for long-term use.

It's hard to say why I decided to write a review about Cardiomagnet. Although the drug, of course, is interesting in its own way, and it is wrong to judge it by reviews, because everyone tolerates it differently.

Doctors (especially in clinics, and not just in hospitals!) Distinguish the category of "professional patients". Unfortunately, I enter this category: I have a lot of diseases, and they are not combined in the best way. So, I ideally fit the definition of this very "professional patient" - I often lie in hospitals, and soon I will know better medicine than my doctor.

All this is to ensure that my review (I hope) will be succinct and informative.

The most important thing is the indications for use. to me Cardiomagnet was prescribed as a prophylaxis for acute myocardial infarction(I have every chance at any time to be in intensive care with this diagnosis, since I am a diabetic), but it has other indications:

• prevention of any thrombosis, first and repeated myocardial infarction;
• prevention of thromboembolism after surgery (separation of a blood clot and blockage of the lumen of the vessel);
• unstable angina.

It is probably worth emphasizing that these are indications for the use of Cardiomagnyl, and not Aspirin (acetylsalicylic acid).

Contraindications to the use of Cardiomagnyl pretty relative. That is, if there is a choice between myocardial infarction and exacerbation of gout, then this choice, I think, is obvious.

But it is worth considering contraindications. It is strongly not recommended to take any ASA drugs in the following conditions:

• hemorrhages in the brain, regardless of the limitation period;
• any tendency to bleeding - from vitamin K deficiency to hemophilia;
• bronchial asthma;
• peptic ulcer of the stomach and duodenum;
• I and III trimester of pregnancy (in the second trimester - only under medical supervision!);
• chemotherapy (treatment with some cytostatics, mainly metatrexate).

At allergic diseases, inactive peptic ulcer and gout Cardiomagnet can be taken, but it is advisable to periodically visit a doctor. This will allow you to assess how much the benefit of this drug exceeds possible harm From him.

O side effects Cardiomagnyl (do not forget that this is, in fact, just a safer "cardiological aspirin") you can talk for a very long time. But this will be clearly superfluous, so I will only talk about the complications that I encountered myself and a few of the most common ones.

When I started taking Cardiomagnet, I did not find any changes - they appeared much later. About six months later I was diagnosed with peptic ulcer.

It somehow happened that I did not immediately go to the doctor with this. I regularly drank Almagel and Rennie, although this, of course, was not a treatment. After examination and diagnosis, it turned out that Almagel should not be drunk together with Cardiomagnil... I was prescribed Omeprazole, which I drink to this day - it helps!

Another unpleasant moment: as a diabetic, it is very important for me to take the correct dosages of any medications. I was prescribed cardiomagnet, but the dose of Glipizide that I am taking to lower my blood sugar level has not been changed. I noticed this very quickly, as soon as my head began to spin more often. : Cardiomagnet significantly enhances the effect of drugs such as Glipizid.

In general, I did not experience any other side effects. My doctor warned me that while taking Cardiomagnyl, something similar to an attack may occur bronchial asthma... This is a common complication of taking all acetylsalicylic acid preparations.

I was instructed in relation to this "attack", and warned that in such a situation, you must immediately use inhaler... I only have Atrovent at home - this drug is suitable. But I never had to use it.

Other side effects are less common. But still, there are cases of hematopoiesis disorders due to the intake of Cardiomagnel, sometimes insomnia occurs. It seems to me that such changes will definitely be noticeable, and they do not pose a particular danger, because they are developing slowly.

To summarize, then Cardiomagnet - good drug... If you follow the dosage and tell your doctor about all the diseases that you have ever suffered, then there should be no problems with this medicine.

Feedback from "Cardiomagnyl"

Come on ... put the pill in your mouth and suck .... how does it feel? Lol. The same will happen in your stomach and especially in the duodenum ... ulcers, guys ... aspirin also causes stomach cancer ... studies in the USA.

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The drug is classified as a drug that prevents blood clots. When should you take "Cardiomagnet", in the morning or in the evening? Its main action is to reduce the formation of blood clots in the lumen blood vessels and prevention of acute myocardial infarction, as well as the drug is used in violation of cerebral microcirculation with damage to brain tissue. The drug should be used according to the instructions for use.

"Cardiomagnet": composition

The main active ingredient acetylsalicylic acid acts, in addition to it, the preparation also contains the following auxiliary components:

• magnesium hydroxide;
• potato starch;
• cellulose;
• a compound of magnesium salt and stearic acid.

"Cardiomagnil" is sold in pharmacies in the form of tablets, which are packaged in bottles (30 or 100 pieces).

In pharmacies, you can buy the drug manufacturer "Nycomed" with a different ratio active ingredients:

1. In the first case, the tablets are produced in the form of hearts. The ratio of acetylsalicylic acid to magnesium hydroxide is seventy-five and fifteen milligrams. The cost of thirty tablets is 150 rubles, the price of one hundred tablets is 260 rubles.
2. The second type is available in the form of oval tablets. The content of active substances is one hundred fifty and thirty milligrams. The cost of "Cardiomagnyl" is 350 rubles.

What diseases is the drug used for?

The drug is effective in combating the following ailments:

1. To prevent the recurrence of thrombosis, as well as after surgery, which helps to restore blood circulation in the arteries of the heart (using shunts).
2. With organic and functional lesions of the myocardium, which are caused by a deficiency in blood supply to the heart muscle.
3. With a focus of infarction, developing as a result of acute damage to the coronary microcirculation.
4. With thrombosis (intravital formation of clots inside the blood vessels that prevent the free flow of blood through circulatory system).
5. For headaches.
6. With serious and life-threatening pathological disorders of cerebral circulation.

And also the drug is used to prevent heart and vascular diseases in patients over fifty-five years old, if they have diabetes, excessive weight gain and high blood pressure. When to take "Cardiomagnet" - is it best in the morning or in the evening?

pharmachologic effect

The medicine belongs to the group non-steroidal drugs with anti-inflammatory and anti-thrombus action:

1. Acetylsalicylic acid reduces the rate of chemical reactions in an enzyme that is involved in the formation of prostanoids. In addition, the element inhibits the process of joining thromboxane A2, as a result of which the process of joining blood clots stops and blood clotting decreases.
2. Magnesium hydroxide is considered the second important element that is included in the preparation. It helps to protect the mucous membrane of the stomach and intestines, as a result of which the risk of developing negative reactions (stomach ulcer, hemorrhage of the gastrointestinal tract) is reduced.

Instructions for use

The medication is administered orally. The capsules must be taken whole with water. The drug can be taken without regard to food, but, as a rule, to prevent the occurrence adverse reactions the drug is best taken after meals:

1. For unstable angina, take one tablet containing acetylsalicylic acid in a dosage of 75 to 150 milligrams in the morning or evening.
2. When take "Cardiomagnet", to prevent recurrence of myocardial infarction as well as thrombosis? In the presence of these diseases, the drug can be taken at any time of the day. Assign one tablet at a dose of up to 150 milligrams once a day.

How to take "Cardiomagnyl" for prophylaxis?

To exclude the occurrence of acute vascular occlusion (thromboembolism) after surgery, take 1 tablet in the same dosage as in myocardial infarction.

In the presence of what violations the drug is prescribed?

For primary prevention of heart disease, "Cardiomagnet" is prescribed in the presence of the following deviations:

• diabetes;
• hyperlipidemia;
• persistent pressure increase;
• obesity;
• smoking.

When to take "Cardiomagnil" - in the morning or in the evening? In such cases, on the first day, one tablet of the drug is prescribed at a dosage of 150 milligrams, on the second day and subsequent one tablet at a dose of 75 milligrams at any time of the day. The duration of the course of therapy depends on many factors, as well as on the severity of the disease. In rare cases, "Cardiomagnet" can be appointed for life. The drug can be purchased at any pharmacy without a prescription.

According to reviews, "Cardiomagnet" perfectly helps to cope with diseases of the heart and blood vessels, and also promotes blood thinning. If you take the drug according to the doctor's instructions and inform him about all the moments of your health, then you can avoid the appearance side effects... Patients can take "Cardiomagnet" in the morning and in the evening, whenever it suits them.

Cardiomagnyl contains 75 mg acetylsalicylic acid and 15.2 mg, the drug Cardiomagnyl Forte contains active substances in a ratio of 150 / 30.39 mg, respectively.

Auxiliary components: magnesium hydroxide and stearate, corn and potato starch, MCC, talc, methyloxypropyl cellulose 15, macrogol.

Release form

• Tablets Cardiomagnyl 75 mg po.
• Tablets Cardiomagnyl Forte 150 mg po.

Tablets 75 / 15.2 mg are available in the form of a stylized "heart", their color is white. Forte tablets are oval in shape, white, with a line on one side.

pharmachologic effect

Reduces the ability of blood corpuscles (in particular, ) to aggregation and reduces the risk of formation blood clots .

Pharmacodynamics and pharmacokinetics

Wikipedia states that acetylsalicylic acid is a salicylic ester of acetic (ethanoic) acid and has the ability to relieve pain, relieve fever and inflammation, and inhibit aggregation platelets .

Acetylsalicylic acid (ASA) irreversibly inhibits the COX-1 enzyme, thereby blocking an important mediator of aggregation and degranulation platelets TXA-2 and aggregation inhibited platelets .

ASA is almost completely absorbed from the gastrointestinal tract. T1 / 2 substance - about 15 minutes. This rate of excretion is due to the fact that in the blood plasma, liver and intestines acetylsalicylic acid quickly hydrolyzed to salicylic acid (SA).

The category of frequent (recorded with a frequency of 0.01 to 0.1) side effects include: insomnia, headache, bronchospasm (in patients with bronchial asthma ), erosive lesions of the upper alimentary canal, diarrhea, nausea, vomiting, dyspepsia, skin rashes of various nature, purpura , , angioedema , erythema multiforme , acute epidermal necrolysis , Stevens Johnson syndrome .

Some patients may:

• hidden bleeding;
• anaphylactic reactions;
• tinnitus;
• ulceration of the walls of the alimentary canal in its upper section (in extremely rare cases, the lower section may also be affected);
• melena;
• vomiting blood;
• perforation of the walls of the alimentary canal and the development of gastrointestinal bleeding;
• hypoglycemia;
• drowsiness;
• vertigo;
• intracerebral bleeding;
• anemia (in patients who receive Cardiomagnet for a long period of time);
• changes in the blood picture (a decrease in the concentration of prothrombin, platelets, neutrophils, leukocytes in the blood; eosinophilia, aplastic anemia; increased levels of alkaline phosphatase and transaminases);
• esophagitis;
• the formation of strictures in the alimentary canal;
• exacerbation of spastic colitis.

Dose-related side effects: acute hepatitis moderate, hearing loss and deafness. The phenomena are reversible.

Tablets Cardiomagnyl: instructions for use

Instructions for the use of Cardiomagnyl

With ischemic heart disease (in any form), the starting dose is 150 mg / day. For maintenance treatment, half the dose is prescribed.

When unstable angina pectoris / for acute myocardial infarction the optimal dosage is from 150 to 450 mg / day. Treatment should be started as soon as possible after the onset of symptoms.

How to take Cardiomagnet for prophylaxis?

To prevent re-education blood clots at the initial stages of treatment, the patient is prescribed 150, later - 75 mg / day.

A prophylactic dose to prevent CVS (for example, acute coronary syndrome ) and thrombus formation - 75 mg / day.

What is Cardiomagnet Forte prescribed for, and what is the optimal dosage?

Forte tablets are indicated for patients with coronary artery disease. Treatment begins with the appointment of 1 tablet / day to the patient. and then switch to half the maintenance dose.

How to take pills?

The medicine is swallowed whole (if it is impossible to chew the tablet, grind it into powder or break it in half) with a liquid.

How to take it correctly - in the morning or in the evening?

There are no clear instructions in the manufacturer's instructions as to what time of day to take Cardiomagnyl tablets.

Doctors, when answering the question “When is it better to take the drug - in the morning or in the evening?”, Recommend drinking the medicine in the evening, about 60 minutes after dinner.

How long can the drug be taken?

The duration of admission depends on the characteristics of the course and the severity of the disease.

In some cases (according to indications, taking into account contraindications and subject to periodic monitoring of blood pressure and hemocoagulation indicators), the drug can be prescribed for life.

How long to take the drug can only be determined by the attending physician.

Overdose

For an adult, a dose of 150 mg / kg is considered dangerous.

A long course of treatment using high doses can cause chronic intoxication, which manifests itself:

• the appearance of ringing in the ears;
• vasodilation;
• nausea;
• dizziness;
• deafness;
• vomiting;
• headache;
• impaired consciousness;
• sweating.

Symptoms of acute poisoning due to overdose are:
heat;

• hyperventilation of the lungs;
• anxiety;
• violations of acid-base balance ( gas (respiratory )alkalosis , metabolic acidosis ).

In severe poisoning, a syndrome of CNS depression develops, which, in turn, can lead to cardiovascular collapse , stopping breathing.

Acute ASA poisoning - in the case of taking a dose exceeding 300 mg / kg - often causes acute liver failure. A lethal dose is more than 500 mg / kg.

Treatment for acute overdose: gastric lavage, administration of enterosorbents, restoration of electrolyte and fluid balance in order to avoid dehydration, , hyperkalemia and hyperpyrexia .

For derivation of derivatives salicylic acid from blood plasma resort to forced alkaline diuresis , hemoperfusion or .

Interaction

Cardiomagnet potentiates the effects:

• anticoagulants ;
• hypoglycemic drugs ;
• methotrexate ;

Reduces the effectiveness of ACE inhibitors, and .

TOolestyramine and antacids worsen the absorption of the drug.

Since Mg is included in the drug in small amounts, the clinical significance of its interaction with the ASA contained in the tablets is minimal.

The drug is not intended for the treatment of children and adolescents.

Does not slow down the rate of reactions, therefore, there are no restrictions on driving vehicles / mechanisms during its use.

What can replace Cardiomagnet?

Analogues of Cardiomagnyl by ATC code, composition of active ingredients and release form: Acard , Asatsil-A , Aspeter , , Acetylsalicylic acid , , , Thrombolic Cardio , Trombogard , Ecorin .

Analogs of the drug with a similar mechanism of action: Avix , Agrenox , Aspigrel , , Vasotik , Monofram , Deplatt , , Ipaton , , Klopilet , Lopigrol , Myogrel , Plavigrel , , Trombex , Effient .

The price of Cardiomagnyl analogues is from 8 rubles.

Which is better: Cardiomagnet or Tromboass?

Thrombo ACC tablets are NSAIDs that are used to prevent stroke , heart attack , , thromboembolism and a number of other pathological conditions. The basis of the drug - acetylsalicylic acid .

The principle of action of Cardiomagnyl and its analogue is based on the ability of ASA to block the synthesis of thromboxane and Pg, which helps to reduce aggregation and adhesion platelets as well as reducing inflammation.

In addition, both drugs reduce K-dependent coagulation factors and increase plasma activity.

The main differences between Cardiomagnet and its substitute: composition and form of release. Thrombo ACC tablets contain 50 or 100 mg of ASA, and magnesium hydroxide is absent. To minimize the negative effect of ASA tablets are covered with a special enteric protective shell.

Patients leave approximately the same reviews about the drugs, but Thrombo ACC, in their subjective opinion, causes unwanted side reactions somewhat less often.

Acecardol and Cardiomagnet - differences

Is a drug, the active ingredient of which is also ASA. Its differences from Cardiomagnyl are the absence of magnesium hydroxide in the composition, the release form (tablets in a to / r shell) and the dosage of ASA (50/100/300 mg / tab.).

Which is better: Cardiomagnet or Aspirin Cardio?

Aspirin Cardio Is the original drug from Bayer AG. The tool belongs to the ASA group of drugs with the greatest evidence base. Thanks to a special enteric coating, its active substance is released not in the stomach, but in the intestinal tract, therefore, Aspirin Cardio is better tolerated by patients than usual acetylsalicylic acid .

Tablets are available in a calendar package, which allows you to improve the control of the patient's implementation of the treatment prescribed by the doctor.

Alcohol compatibility

With the simultaneous intake of alcohol and ASA, an additive effect is observed.

Cardiomagnet during pregnancy

In the 1st trimester, taking high doses of salicylates is associated with an increased incidence of fetal defects.

In the 2nd trimester, drugs in this group are used taking into account therapeutic effect for the mother's body and potential risks for the unborn child.

In the last 3 months of pregnancy, salicylates are contraindicated. In the 3rd trimester, high doses of ASA can cause inhibition of labor, increased bleeding (both in the mother and in the fetus), and premature closure of the botalle duct in the fetus.

The use of ASA immediately before childbirth can provoke hemorrhagic cerebrovascular accident (especially in premature babies).

Salicylates and their metabolic products pass into breast milk. Accidental intake of a small dose of ASA during lactation does not require termination of breastfeeding and is not accompanied by the development of undesirable effects in the child. However, high doses or long-term use of these drugs requires discontinuation of hepatitis B.

Reviews during pregnancy allow us to conclude that most often the drug is prescribed to prevent thrombotic complications in risk groups, in complex therapy placental insufficiency and gestosis as well as for treatment polyhydramnios .

Almost all expectant mothers noted that Cardiomagnet is well tolerated, while improvements (in particular, a decrease in viscosity and an increase in blood mobility) become noticeable after 10-14 days of treatment.

Reviews about Cardiomagnyl

There are different reviews about Cardiomagnyl on the forums. Most patients taking these pills as prescribed by a doctor are happy with them, but sometimes negative reviews are also encountered. The main reasons for the low valuation of the product are its high price and side effects.

Research results and expert reviews allow us to conclude that ASA is the main drug. antithrombotic therapy in patients at risk cardiovascular pathologies (including those arising during pregnancy).

An important feature of Cardiomagnyl is the presence in its composition of Mg hydroxide - a “buffer” that prevents the damaging effects of ASA and, in particular, erythematous-hemorrhagic form of NSAID gastropathy .

Studies have shown that Cardiomagnet is more effective than enteric dosage forms, suppresses aggregation platelets ... At the same time, the frequency of adverse reactions from the organs of the digestive system was the lowest in comparison with the usual and aspirin , which comes in the form of an enteric tablet.

Thus, having the same indications and contraindications for use as the usual ASA, Cardiomagnet is much safer, but at the same time no less effective remedy for the prevention of complications of CVS diseases.

Cardiomagnyl price: how much does 75 mg / 15.2 mg and 150 mg / 30.39 mg cost?

The average price of tablets of Cardiomagnyl 75 mg No. 100 in Ukrainian pharmacies is 85 UAH. You can buy Forte tablets for 95-98 UAH (packing # 100). At the same time, the cost of the drug in Zaporozhye, Kiev, Kharkov or Odessa differs slightly.

The price of Cardiomagnyl in Moscow and St. Petersburg is from 120 rubles. per package No. 30 and from 215 rubles. for packing No. 100. The cost of Forte tablets is from 125 per pack # 30 and 260 rubles. and from for packing No. 100.

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ZdravCity

Cardiomagnet tab. p.p. 75mg + 15.2mg n100Takeda Pharmaceuticals LLC

Cardiomagnet tab. p.p. 150mg + 30.39mg n30Nycomed GmbH / Takeda GmbH / Takeda Pharmaceuticals LLC

Cardiomagnet tab. p.p. 75mg + 15.2mg n30Nycomed GmbH / Takeda GmbH

Cardiomagnet is an anti-inflammatory drug (non-steroidal), antiplatelet agent that is used to prevent the development of thrombosis and acute heart failure in patients with certain CVD diseases or risk factors that increase the complications of these diseases.

The anti-inflammatory effects of the drug are associated with irreversible inhibition of cyclooxygenase-1 by acetylation and blocking the formation of thromboxane A2. All this leads to the suppression of the aggregation of platelet blood cells, and hence the prevention of thrombus formation.

Pharmaceutical group: NSAIDs, antiplatelet agents.

Composition of cardiomagnyl for 1 tablet:

• Basic substance: acetylsalicylic acid -75 mg, magnesium hydroxide - 15.2 mg. The form of the drug "forte" contains 2 times the dose of active ingredients: acetylsalicylic acid - 150 mg, magnesium hydroxide - 30.39 mg.
• Excipients: magnesium stearate, corn and potato starch, microcrystalline cellulose.
• Shell composition: hypromellose, propylene glycol, talc.

Produced in brown glass bottles of 30 and 100 tablets. Price:

• 75 mg No. 100 - 200-250 rubles,
• 150 mg No. 100 - 300-400 rubles.

pharmachologic effect

Cardiomagnet is characterized by a pronounced antiplatelet effect. The well-known acetylsalicylic acid, which is part of the drug, in large doses (500 mg - the average therapeutic dose for an adult) has a pronounced anti-inflammatory effect, eliminates pain, inflammation and elevated temperature... In small doses, it prevents platelets from sticking together, the formation of blood clots, and also has a mild anti-inflammatory effect:

• irreversibly inhibits cyclooxygenase-1, which is involved in the formation of prostaglandins, which trigger an inflammatory reaction in the body;
• inhibits the synthesis of thromboxane A2 in platelets, thus preventing their aggregation (adhesion).

To achieve these effects, the drug should be used for a long time, in the recommended doses.

Magnesium hydroxide has a protective effect on the gastrointestinal mucosa and protects it from the action of acetylsalicylic acid.

Pharmacokinetics

Acetylsalicylic acid (ASA) is fully absorbed from the gastrointestinal tract. The hydrolysis reaction to salicylic acid is carried out with the help of hepatic esterases in the liver, as well as in the blood plasma and intestines. The half-life of ASA is about 15 minutes, and the half-life of salicylic acid is about 3 hours. Additional intake of ASA (above 3 g) can lengthen the half-life of the metabolite (salicylic acid) due to the absolute saturation of enzyme systems.

The bioavailability of salicylic acid is 80-100%, i.e. is high. The bioavailability of ASA varies by 70%, but it can be changed due to presystemic hydrolysis in the gastric wall, as well as in the intestine and liver. It is very important that magnesium hydroxide does not in any way affect the bioavailability of ASA.

Indications

Indications for the use of cardiomagnyl are as follows:

• Primary prevention of heart and vascular diseases - thrombosis and acute heart failure against the background of risk factors: diabetes mellitus, arterial hypertension, hyperlipidemia, obesity, smoking, old age;
• Prevention of recurrent myocardial infarction and blood vessel thrombosis;
• Prevention of thromboembolism after vascular surgery: aorto coronary artery bypass grafting, coronary angioplasty (transluminal);
• Angina pectoris is unstable.

Contraindications

The instructions for use of cardiomagnyl indicate the following restrictions on use:

• Hemorrhage in the brain tissue;
• Bleeding tendency against the background of vitamin K deficiency, hemorrhagic diathesis, thrombocytopenia;
• Erosive and ulcerative pathologies of the gastrointestinal tract in the exacerbation phase;
• Gastrointestinal bleeding;
• Bronchial asthma induced by treatment with salicylates and NSAIDs;
• Severe renal dysfunction (CC
  

  The risk of sudden formation of cardiovascular diseases is present in a person, regardless of his age. Moreover, among those who have crossed the forty-year line, diseases of the heart and blood vessels are observed almost without exception, and ignoring this problem often ends in death.

  With a tendency to this kind of disease and just for preventive purposes, it is necessary to undergo regular examinations and support the body with fortifying drugs. Often, patients are prescribed cardiomagnet, which is a measure for the prevention of cardiac and vascular pathologies. However, any medicine has its own advantages and disadvantages, expressed in limited consumption and side effects on the body. When cardiomagnet is beneficial, and when it should not be drunk are the main questions that we will consider today.

  What is Cardiomagnyl?

  Cardiomagnet is a drug that acts as an anti-inflammatory agent. It is not a narcotic substance and does not affect hormone levels (non-hormonal agent).

  The main active components of cardiomagnyl are magnesium hydroxide and acetylsalicylic acid (ASA), the effect of which is fixed by auxiliary substances - potato and corn starch, magnesium stearate, talc, cellulose, propylene glycol.

  The Nicomed company produces cardiomagnyl in the form of tablets, which differ in the content of active ingredients. In some, the amount of ASA and magnesium hydroxide is 75 and 15.2 mg, respectively. In others, it is exactly twice as much (150 and 30.4 mg).

  The main purpose of cardiomagnyl is the treatment and prevention of diseases and pathologies of the heart and blood vessels. The action of ASA on the body is manifested in preventing the formation of blood clots, preventing heart attacks and strokes, it also lowers body temperature and has an anti-inflammatory effect. Antacid (magnesium hydroxide) protects the walls of the gastric mucosa from damage and irritation caused by exposure to ASA.

  Studies confirm that regular intake of cardiomagnyl helps to eliminate the risk of damage to the cardiovascular system by 25%.

  Composition of the preparation (in 1 tablet), release form

  Active substance

  • Magnesium hydroxide - 75/150 mg
  • Acetylsalicylic acid - 15/30 mg

  Excipient

  • corn starch - 9.5 / 18 mg,
  • microcrystalline cellulose - 12.5 / 25 mg,
  • magnesium stearate - 150/300 mcg,
  • potato starch - 2.0 / 4 mg.

  Shell composition

  • hypromellose (methylhydroxypropylcellulose 15) - 0.46 / 1.2 mg
  • talc -280/720 mcg
  • propylene glycol - 90/240 mcg

  Available in 30 and 100 pcs.

  When is cardiomagnyl necessary?

  This drug is most often prescribed in the following cases:

  • while recovering from a stroke or heart attack caused by thrombosis
  • treatment and protection from ischemic disease heart, atherosclerosis, thrombosis, myocardial infarction, ischemic stroke
  • diabetes
  • hereditary tendency to cardiovascular disease
  • obesity
  • constant high blood pressure
  • migraine
  • smoking abuse in combination with an increased risk of cardiovascular disease
  • excess cholesterol in the blood
  • embolism
  • unstable angina
  • poor blood supply to the brain
  • after coronary artery bypass grafting and angioplasty for the prevention of blood clots

  Cardiomagnyl should not be taken by men under 50 and women under 40, since the risks of cardiovascular problems in these age groups are low. But its constant use not under the supervision of a specialist can lead to internal bleeding.

  Do not take cardiomagnet for:

  • individual intolerance to cardiomagnyl
  • exacerbation of stomach and duodenal ulcers
  • bleeding tendencies
  • gout
  • bleeding in the digestive system
  • cerebral stroke
  • pregnancy and lactation (only with a doctor's prescription)
  • bronchial asthma resulting from the intake of salicylates or non-steroidal anti-inflammatory drugs
  • children under 18 years of age cardiomagnet is prohibited
  • acute renal failure
  • treatment with methotrexate

  Taking cardiomagnyl after treatment of peptic ulcer disease, bleeding, asthma, gout, liver and kidney failure, with a tendency to allergies, nasal polyps, hay fever and pregnancy is only possible on the recommendation of a doctor.

  Side effects when taking cardiomagnyl

  The risk of negative reactions of the body to cardiomagnet increases with increasing dosages of the drug. This is why it is so important not to start. self-treatment, but contact a qualified doctor who will select the permissible daily amount of the drug for you personally.

  If you take up to 100 mg of cardiomagnyl per day, there is practically no risk of side effects.

  When this threshold is exceeded, the following side effects of cardiomagnyl are possible:

  • skin rashes
  • laryngeal edema
  • anaphylactic shock due to acute drug resistance by the body
  • nausea, vomiting
  • heartburn, stomach pain
  • irritable bowel syndrome
  • colitis
  • anemia
  • stricture
  • stomatitis
  • damage to mucous membranes causing bleeding
  • narrowing of the bronchi
  • increased bleeding, since ASA worsens blood clotting
  • eosinophilia
  • thrombocytopenia
  • hypoprothrombinemia
  • agranulocytosis
  • headache
  • poor coordination of movements
  • drowsiness, lethargy
  • tinnitus
  • sleep disorders
  • cerebral hemorrhage (extremely rare side effect)

  Optimal dosages of cardiomagnyl and its administration for certain diseases

  The cardiomagnyl tablet must be chewed and washed down with plenty of water.

  In case of thrombosis, hyperlipidemia, hypertension, obesity, acute heart failure and diabetes mellitus, as well as for preventive purposes on the first day of the course, it is recommended to drink 1 tablet of cardiomagnil-forte (150 mg ASA and 30.39 mg magnesium hydroxide). On the following days, you can take 1 tablet of cardiomagnyl with an ASA content of 75 mg. According to the same scheme, the drug should be taken by elderly people and heavy smokers.

  To prevent a second heart attack and the formation of blood clots, you need to take cardiomagnyl daily, 1 tablet, but only after an individual examination by a specialist cardiologist.

  If you have undergone operations on the vessels, then in order to avoid sticking them together from the doctor's prescription, you also need to take a cardiomagnyl tablet a day. For unstable angina, treatment will be similar.

  During pregnancy, cardiomagnet is prohibited in the first 3 months. In the second and third trimester, the drug can be taken in limited quantities, which are determined by the doctor based on your individual indicators.

  When feeding, an inconsistent intake of the drug is not dangerous for the child, however, the need for regular treatment with Cardiomagnum requires a switch to artificial feeding.

  Combination of cardiomagnyl with certain drugs

  1. Cardiomagnet in combination with thrombolytic therapy drugs, anticoagulants or antiplatelet drugs further worsen blood coagulation.
  2. It is not recommended to combine cardiomagnet with almagel.
  3. Cardiomagnet, when used continuously in large doses, lowers glucose levels. It should be taken with caution by diabetics, avoiding the combination of cardiomagnyl with drugs that lower blood sugar levels.
  4. Ibuprofen significantly reduces the effectiveness of cardiomagnyl.
  5. Cardiomagnet and alcohol are incompatible, as this will cause enormous harm to the digestive organs.
  6. Cardiomagnet taken along with methotrexate reduces blood production.

  Consequences of an overdose of Cardiomagnum

  An overdose occurs when a large dose of the drug is taken - over 150 mg of ASA per 1 kg of body weight. The consequences of this are poor coordination, tinnitus, vomiting, foggy thoughts, and hearing impairment.

  Among the more severe consequences of uncontrolled intake of cardiomagnyl are heart failure, chills, shortness of breath, hypoglycemia, and even coma.

  At the first signs of an overdose with cardiomagnum, you should wash the stomach and take activated charcoal (1 tablet of charcoal per 10 kg of weight). For more severe symptoms, call an ambulance right away.

  How to replace cardiomagnet?

  Among the analogues of the drug are Thrombo-ass and Aspirin-cardio. However, they do not contain a protective element - magnesium hydroxide. Only your attending physician can choose between cardiomagnum and analogs.

  Since cardiomagnet is drug, which has its own healing properties, contraindications and side effects, then one should approach it wisely, avoiding self-diagnosis and self-medication. Reception of cardiomagnyl should take place under the constant supervision of doctors.

  Video about the benefits and dangers of cardiomagnyl

  For a long time, the media "chewed" on the heart, and not only for them, the benefits of prevention - aspirin. Cardiomagnyl contains blood thinning aspirin. The second component is magnesium. Why Magnesium? He is a friend of the heart, no less. About both components of the drug is - in more detail.

  Instructions for the use of cardiomagnyl

  The opinion about the purpose of instructions (annotations) for drugs exclusively for study by specialists is controversial. Specialists are obliged to own information "by default". Complex chains of chemical reactions associated with metabolism are their business and interest.

  But the patient has the right, and must know why, for what purpose, the medicine is prescribed to him. What is its effect, what will happen in the body after ingestion. What is the threat of neglect of treatment: the person will also understand the risks according to the instructions.

  Indications, contraindications must be read. Especially the second. Doctors are overwhelmed, they do not always keep the "set" of diagnoses in their heads. Provide yourself with additional insurance.

  Operating principle

  Cardiomagnet, a commonwealth of aspirin and magnesium, is an antiplatelet agent. A substance that prevents blood platelets from sticking together. Platelets are not human enemies, they are normally defenders. Bleeding is stopped precisely due to adhesion. But with a number of diseases, the blood thickens.

  In everyday life they say: "Prothrombin is high." Increased blood clotting. In such an environment, thrombosis is likely. This threatens a vascular catastrophe. May develop:

  • Stroke;
  • Heart attack - and not only of the myocardium - of any organ, the supplying vessel of which is clogged with a thrombus;
  • Blockage of small arteries in the extremities, leading to a congestive inflammatory process. As this disorder progresses, it can cause gangrene.

  Cardiomagnet prevents complications due to its constituent substances.

  Aspirin

  Scientists have long established that acids thin the blood. Anti-inflammatory aspirin is an acid. Acetylsalicylic. In small doses, it has been successfully used in the prevention of thrombosis. In an emergency (heart attack, hypertensive crisis, a sharp rise in blood sugar), aspirin is chewed in the mouth. We have to ignore the burning effect of the drug on the mucous membranes. This is how acid works faster.

  The importance of aspirin has been recognized by the medical world for a long time, it is undeniable. The number of vascular accidents is reduced by a quarter, the medicine saves lives. Heart attacks, strokes in many cases are prevented by aspirin help. This has been proven by doctors and pharmacists in many countries, there is no disagreement.

  It is better to avoid force majeure conditions. Aspirin is salutary, but burning the mucous membrane of the mouth, it does the same from the mucous membrane of the stomach. Therefore, pharmacists have created soft, gastrointestinal, forms of antiplatelet agents. Cardiomagnet is one of those. Aspirin is released slowly, its content is low. The therapeutic effect is constant (with regular admission).

  Magnesium

  The drug is "covered" and supplemented with magnesium. Magnesium in the form of hydroxide is an antacid (a substance that reduces the acidity of the medium). It softens the aggressiveness of aspirin while protecting the stomach. This element is nutritious for the muscles of the heart. Lack of magnesium is fraught with arrhythmias of a different nature. With arrhythmic seizures, vortices of the blood flow are formed, the risk of blood clots increases many times. Cardiomagnesium magnesium prevents this chaos.

  If magnesium is not in short supply, the heart consumes one-fifth of its total. Twenty percent is the norm for the myocardium. With a lack of a trace element, the heart has to compete with the brain, kidneys and skeletal system... The opponents are serious. The fight for magnesium weakens the functional abilities of organs and systems.

  A diet enriched with a useful element will not quickly correct the situation. Cardiomagnet - maybe. Saturating the body with magnesium in the proper amount, a person facilitates the work of the myocardium. This is sometimes enough to normalize the disturbed rhythm.

  When prescribing treatment, the doctor usually prescribes the duration of the course. But this drug, in the absence of allergies or contraindications, is always beneficial. Can be taken continuously.

  Release form, packaging

  Manufacturers have taken care of the aesthetic component. The drug is produced in tablets original look: heart-shaped. The relationship is psychologically subtle. Patients of a cardiologist are usually one of those who are “close to heart” and take what is happening. A compact bottle with instructions attached directly to it, a touching-looking pill - it calms, pre-sets you on the positive.

  The patient believes - the heart is protected, trust is also an element of treatment. A nuance of design (a drop of tar): the instructions are folded in a narrow accordion, the text is too small. When turning, get a tape of thirty centimeters. You will have to read with a magnifying glass, especially for those with vision problems.

  And in patients using antiplatelet agents, vision is one of the targets of disease. Read the “transcript” on the website - the article exhaustively provides the information the drug consumer needs. The annotation, which is difficult to read on the bottle, does not in the least reduce the effectiveness, the benefits of the drug itself.

  The tablets are coated with excipients. This provides a slow, sustained release of the components. From admission to the next - a person insures the heart from overload.

  Indications for use

  Cardiomagnet is a means of prevention, protection. The medicine prevents heart attacks, insures against strokes. Therefore, with the existing risk for the heart, blood vessels, it is prescribed:

  • Patients with high rates"Bad" cholesterol;
  • Patients with diabetes mellitus;
  • Overweight;
  • Suffering from arterial hypertension (hypertension);
  • Elderly weakened people;
  • Smokers;
  • With ischemic heart disease, angina pectoris.

  The modernity of the equipment, the qualifications of specialists performing virtuoso operations on vessels do not exclude postoperative complications. To prevent the formation of blood clots - thrombi, postoperative intake of antiplatelet agents is required. This is insurance against thromboembolism - closure of the lumen of the vessel, clogging it with a thrombus.

  The shell of the heart pill dissolves in the intestine and is absorbed there. Alkaline environment intestine partially neutralizes the sharp action of acetylsalicylic acid.

  Patients are naturally interested in whether it is possible to take cardiomagnet all the time. The drug is specially designed for long-term use. Therefore, it is successfully used for a long time:

  1. With angina pectoris, even unstable (earlier it was called a pre-infarction state). Treatment begins already in the acute period, in combination with the medications necessary to relieve the acute phase.
  2. To protect against re-infarction.
  3. With insufficient blood supply to the brain.
  4. In the treatment of stroke (ischemic), from the first days - also for a long time.
  5. To improve the condition of varicose patients.

  Opinions differ regarding the mechanism of ulcerative complications of the gastrointestinal tract from taking aspirin-containing drugs. They are as follows:

  1. The acid acts directly on the mucous membranes.
  2. Aspirin does not directly affect the mucous membranes; after absorption, it blocks the enzymes of their regeneration. The mucous membranes become thinner and damaged by their own hydrochloric acid stomach.

  While scientists argue, the consumer draws unambiguous conclusions. No contraindications - cardiomagnet containing aspirin is beneficial. It prolongs life, protecting the heart, protecting the vessels of the brain. At the same time relieves pain inflammatory processes, acts antipyretic.

  It is proved: the component of cardiomagnyl - aspirin prevents erectile dysfunction. Protects against the danger of colon cancer: its incidence is 40% lower in those taking the drug. All this at a dosage of only 75 mg at night.

  Contraindications

  Cardiomagnet is not shown to everyone. Sometimes it is impossible to thin the blood. Do not prescribe medication when there are:

  • Bleeding of any etiology or tendency to them;
  • Aspirin intolerance (ASA);
  • Hemophilia, thrombopenia, other blood clotting problems;
  • Chronic and acute renal and hepatic failure;
  • Pregnancy, especially the first trimester and last weeks;
  • Cerebral hemorrhage;
  • Gout;
  • Bronchial asthma;
  • Hypertensive crisis with very high (260 and above) diastolic blood pressure: aspirin can harm, the risk of stroke from a violation of the integrity (rupture) of the vessel increases;
  • Children's age, adolescence (up to 18) - too;
  • Exacerbation of ulcers and / or erosions of the gastrointestinal tract;
  • Lactation;
  • Do not combine cardiomagnet with other antiplatelet agents (valsortan, clopidogrel, curantil, etc.);
  • Do not use the medicine while taking cytotoxic drugs. They act aggressively and can damage the mucous membranes of the gastrointestinal tract. Cardiomagnet is able to enhance the negative effect of cytostatics.

  How to take the drug

  You can find different opinions: how to drink cardiomagnet - in the morning or in the evening. It is reasonable to be guided here by the physiology of the organism. The activity of his systems slows down at night. Pulse decreases, blood circulation becomes slower. Metabolism slows down. In the early morning hours, the blood is thicker than in the rest. It is during this time period that most of the troubles occur inside the body. Strokes, heart attacks, according to statistics, "love" the night and pre-dawn time.

  It is necessary to thin the blood on time. Therefore, they drink cardiomagnum - before bedtime. Releasing slowly, at night and in the morning, the drug reaches a dose in the blood that protects against problems. Drunk in the morning, it won't hurt. But the heart, tired during the day and forced to pump thick blood at night, will not be safe either.

  Therefore, the question of when it is better to take cardiomagnet, whether to drink it in the morning or in the evening, becomes clear. The medicine is taken once a day, every evening. The dosage is determined by the doctor, tablets are available in 150 mg or in half the dose - 75 mg. The presence of acid (ASA), although in the shell, and in combination with emollient magnesium, requires caution: they are taken after meals. Most often, a dose of 75 mg is prescribed, it is sufficient for the therapeutic protective effect of blood thinning.

  Do not crush, chew or crush the tablet. This will compromise the integrity of the film covering it. The drug will begin to be absorbed immediately in the stomach. The meaning is lost: the acid acts on the unprotected mucous membrane almost like aspirin in its pure form. Released quickly. The medicine loses its prolonged effect, the blood liquefies for a short time.

  Grinding cardiomagnyl is allowed in emergency cases: when removing an acute heart attack, if there is no ordinary aspirin. In other situations, with constant use, vary the dosage by choosing when buying. Take either tablets containing 150 mg ASA, or 75 mg. The pill is washed down with water.

  Side effects

  The old acquaintance aspirin did not become completely safe from this acquaintance. It has been used for a long time (it has been a long-liver from medicine for more than 150 years), and its irritating mucous ability has also been known for a long time. Sometimes even a small dose causes ulceration of the membranes inside the gastrointestinal tract. Therefore, earlier, acetylsalicylic acid was washed down without fail - with milk. Cardiomagnet spares the stomach and intestines. But no one will undertake to completely eliminate the damaging effect, to guarantee good tolerance by all patients. Side effects are as follows:

  1. Allergic reaction - any substance can unexpectedly provoke an allergy, up to and including shock. Cardiomagnyl acetylsalicylic acid or magnesium can also.
  2. Pathological influence on the regeneration process of the gastrointestinal mucosa. The cells of the human body are constantly in the process of renewal. This is a physiological process: old ones are replaced by new ones. The action of the drug sometimes disrupts the formation of young replacement epithelial cells. And the old ones are more susceptible to the erosive process and the formation of ulcers. Bleeding from ulcerated mucous membranes is not excluded - even with minimal, but prolonged administration of the drug.
  3. Heartburn, vomiting, nausea are common side effects.
  4. The mucous membrane of the mouth can react - sometimes stomatitis is recorded.
  5. The indicators of the rheological properties of blood (its fluidity) may change. Biochemical control is necessary even with visible well-being. Periodic analyzes are needed. Based on the results, the doctor will allow you to continue taking the drug, cancel the drug, or adjust the duration with a pause in the course of treatment with Cardiomagnum. This will prevent the formation of a tendency to bleeding.
  6. Aspirin and alcohol are incompatible. This is a blow to the liver, and a powerful one. Cardiomagnet frankly does not detect aspirin with the name, but it is important to know about the presence of the latter in the composition so as not to harm yourself.
  7. Bronchospasm. It occurs unexpectedly if the prerequisites for bronchial disorders are latent.
  8. Sleep disturbance - Possibly restless sleep or insomnia.
  9. Any drug is a help, but also a foreign interference in the metabolic cycle. As a result, drowsiness and dizziness are not excluded.
  10. In case of impaired salt metabolism, harmless cardiomagnet can contribute to the formation of gout.
  11. By thinning the blood, the drug reduces at the same time " sugar indicators»: Blood glucose decreases. Diabetes patients should remember this. In combination with insulin or glucose-lowering tablets, cardiomagnet is undesirable.

  The appointment is given by the doctor, the patient feels the reaction. If it does not meet expectations, the issue is discussed together.

  What if cardiomagnet is not allowed?

  The patient does not have to develop side effects. But - there are sometimes. There are also contraindications. What if you need to be careful, the blood needs to be diluted, and the drug "does not go"? This can even happen from an excess of magnesium. Rarely - but not impossible. Or you need it urgently, but not available. Or the price does not suit. How to replace the cardiomagnet? Pharmaceuticals are not marking time. She can suggest:

  1. Drugs similar action with aspirin - acecardol, cardiASK, thrombotic ACC, aspicor, aspirin Cardio.
  2. In case of intolerance to aspirin, the doctor may prescribe anticoagulants that do not contain it and other drugs - warfarin, trental, tiklid. A lot of means have been synthesized. Each medicine has its own indications and contraindications.

  Patients at risk can help themselves. Adding a little natural to drinks (compote, tea) in the evening apple cider vinegar, you will make the drink healthful. This drink will improve the fluidity of the blood by thinning it. Blood glucose will also decrease. Even half a glass of homemade kvass will do the same. Try, check, confirm guesses with test results. Medicines are also not irreplaceable.

  The problems of the vascular system are not an easy one. When they come close, there is no need to despair. Whatever the diagnosis turns out to be, you have the main thing: you are alive. With your hands down, it's easy to jeopardize this point.

  Gathering mentally, you can pull yourself up physically. Understand how to act, support the body. Improve or prevent quality of life from deteriorating for as long as possible. Right choice the drug (maybe cardiomagnyl) in serious cases is vital. Try to calm down and you will succeed.

  Compound

  Cardiomagnyl contains 75 mg acetylsalicylic acid and 15.2 mg magnesium hydroxide, the medicine Cardiomagnyl Forte contains active substances in a ratio of 150 / 30.39 mg, respectively.

  Auxiliary components: magnesium hydroxide and stearate, corn and potato starch, MCC, talc, methyloxypropyl cellulose 15, macrogol.

  Release form

  • Tablets Cardiomagnyl 75 mg po.
  • Tablets Cardiomagnyl Forte 150 mg po.

  Tablets 75 / 15.2 mg are available in the form of a stylized "heart", their color is white. Forte tablets are oval in shape, white, with a line on one side.

  pharmachologic effect

  Reduces the ability of blood corpuscles (in particular, platelets) to aggregation and reduces the risk of formation blood clots.

  Pharmacodynamics and pharmacokinetics

  Wikipedia states that acetylsalicylic acid is a salicylic ester of acetic (ethanoic) acid and has the ability to relieve pain, relieve fever and inflammation, and inhibit aggregation platelets.

  Acetylsalicylic acid(ASA) irreversibly inhibits the COX-1 enzyme, thereby blocking an important mediator of aggregation and degranulation platelets TXA-2 and aggregation inhibited platelets.

  ASA is almost completely absorbed from the gastrointestinal tract. T1 / 2 substance - about 15 minutes. This rate of excretion is due to the fact that in the blood plasma, liver and intestines acetylsalicylic acid quickly hydrolyzed to salicylic acid (SA).

  For salicylic acid T1 / 2 - about 3 hours. With the saturation of enzyme systems, which is observed with the simultaneous administration of ASA in a dose exceeding 3 g, the indicator can increase significantly.

  The bioavailability of ASA is about 70%. The indicator is variable due to the fact that the substance under the influence of enzymes undergoes presystemic hydrolysis. The bioavailability of SC ranges from 80 to 100%.

  The doses of magnesium hydroxide used do not affect the bioavailability of ASA.

  Indications for use of Cardiomagnyl

  The method of administration and doses depend on the indications for the use of the drug.

  Cardiomagnet tablets - what are they from?

  Indications for use of Cardiomagnyl:

  • acute ( myocardial infarction(THEM), unstable angina) or chronic ischemic heart disease;
  • primary prevention of CVD diseases in patients at risk (obese, diabetes mellitus, arterial hypertension, hypercholesterolemia, as well as those with a family history of indications of myocardial infarction under the age of 55);
  • primary prevention acute venous thrombosis and prevention of re-education blood clots(secondary prevention of thrombus formation).

  What is the medicine for Cardiomagnet Forte?

  Forte tablets are shown when Ischemic heart disease(acute or chronic).

  Contraindications to Cardiomagnet

  The annotation lists the following contraindications for the drug:

  • hypersensitivity to ASA, other salicylates;
  • intolerance to any of the auxiliary components of the tablets;
  • aggravated peptic ulcer;
  • bleeding tendency ( hemophilia,thrombocytopenia, failure vitamin K);
  • severe dysfunction (with GFR below 10 ml per minute) or kidney failure;
  • severe cardiac decompensation;
  • triggered by the use of NSAIDs / salicylates angioedema or bronchial asthma history;
  • childhood;
  • the last trimester of pregnancy;
  • simultaneous reception methotrexate at a dose exceeding 15 mg / week.

  Side effects

  Most often (in about every 10th patient), during the use of Cardiomagnyl, the following were recorded: a decrease in aggregation platelets, increased bleeding, reflux and heartburn.

  The category of frequent (recorded with a frequency of 0.01 to 0.1) side effects include: insomnia, headache, bronchospasm(in patients with bronchial asthma), erosive lesions of the upper alimentary canal, diarrhea, nausea, vomiting, dyspepsia, skin rashes of various nature, purpura, hives, angioedema, erythema multiforme, hemorrhagic vasculitis, acute epidermal necrolysis, Stevens Johnson syndrome.

  Some patients may:

  • hidden bleeding;
  • allergic rhinitis;
  • anaphylactic reactions;
  • tinnitus;
  • ulceration of the walls of the alimentary canal in its upper section (in extremely rare cases, the lower section may also be affected);
  • melena;
  • vomiting blood;
  • perforation of the walls of the alimentary canal and the development of gastrointestinal bleeding;
  • hypoglycemia;
  • drowsiness;
  • vertigo;
  • intracerebral bleeding;
  • anemia (in patients who receive Cardiomagnet for a long period of time);
  • changes in the blood picture (a decrease in the concentration of prothrombin, platelets, neutrophils, leukocytes in the blood; eosinophilia, aplastic anemia; increased levels of alkaline phosphatase and transaminases);
  • esophagitis;
  • stomatitis;
  • colitis;
  • the formation of strictures in the alimentary canal;
  • exacerbation of spastic colitis.

  Dose-related side effects: acute hepatitis moderate, hearing loss and deafness. The phenomena are reversible.

  Tablets Cardiomagnyl: instructions for use

  Instructions for the use of Cardiomagnyl

  With ischemic heart disease (in any form), the starting dose is 150 mg / day. For maintenance treatment, half the dose is prescribed.

  When unstable angina pectoris/ for acute myocardial infarction the optimal dosage is from 150 to 450 mg / day. Treatment should be started as soon as possible after the onset of symptoms.

  How to take Cardiomagnet for prophylaxis?

  To prevent re-education blood clots at the initial stages of treatment, the patient is prescribed 150, later - 75 mg / day.

  A prophylactic dose to prevent CVS (for example, acute coronary syndrome) and thrombus formation - 75 mg / day.

  What is Cardiomagnet Forte prescribed for, and what is the optimal dosage?

  Forte tablets are indicated for patients with coronary artery disease. Treatment begins with the appointment of 1 tablet / day to the patient. and then switch to half the maintenance dose.

  How to take pills?

  The medicine is swallowed whole (if it is impossible to chew the tablet, grind it into powder or break it in half) with a liquid.

  How to take it correctly - in the morning or in the evening?

  There are no clear instructions in the manufacturer's instructions as to what time of day to take Cardiomagnyl tablets.

  Doctors, when answering the question “When is it better to take the drug - in the morning or in the evening?”, Recommend drinking the medicine in the evening, about 60 minutes after dinner.

  How long can the drug be taken?

  The duration of admission depends on the characteristics of the course and the severity of the disease.

  In some cases (according to indications, taking into account contraindications and subject to periodic monitoring of blood pressure and hemocoagulation indicators), the drug can be prescribed for life.

  How long to take the drug can only be determined by the attending physician.

  Overdose

  For an adult, a dose of 150 mg / kg is considered dangerous.

  A long course of treatment using high doses can cause chronic intoxication, which manifests itself:

  • the appearance of ringing in the ears;
  • vasodilation;
  • nausea;
  • dizziness;
  • deafness;
  • vomiting;
  • headache;
  • impaired consciousness;
  • sweating.

  Symptoms of acute poisoning due to overdose are:
  heat;

  • hyperventilation of the lungs;
  • anxiety;
  • violations of acid-base balance ( gas(respiratory)alkalosis, metabolic acidosis).

  In severe poisoning, a syndrome of CNS depression develops, which, in turn, can lead to cardiovascular collapse, coma stopping breathing.

  Acute ASA poisoning - in the case of taking a dose exceeding 300 mg / kg - often causes acute liver failure. A lethal dose is more than 500 mg / kg.

  Treatment for acute overdose: gastric lavage, administration of enterosorbents, restoration of electrolyte and fluid balance in order to avoid dehydration, acidosis, hyperkalemia and hyperpyrexia.

  For derivation of derivatives salicylic acid from blood plasma resort to forced alkaline diuresis, hemoperfusion or hemodialysis.

  Interaction

  Cardiomagnet potentiates the effects:

  • anticoagulants;
  • hypoglycemic drugs;
  • methotrexate;
  • acetazolamide.

  Reduces the effectiveness of ACE inhibitors, spironolactone and furosemide.

  TOolestyramine and antacids worsen the absorption of the drug.

  Since Mg is included in the drug in small amounts, the clinical significance of its interaction with the ASA contained in the tablets is minimal.

  Combined with Probenecid there is a mutual weakening of the action of both drugs.

  GCS, enhancing the excretion of derivatives salicylic acid, thereby weaken their effect.

  Terms of sale

  Non-prescription drug.

  Storage conditions

  The room where the tablets are stored must be kept at a temperature of up to 25 ° C.

  Best before date

  special instructions

  Long-term concomitant use of the drug with NSAIDs increases the risk of adverse reactions.

  In elderly people, prolonged use of Cardiomagnyl increases the likelihood of gastrointestinal bleeding.

  In the case of a planned operation, the pills are stopped a few days before the surgery.

  The agent is used with caution in allergy sufferers, patients bronchial asthma, at kidney / liver dysfunction, existing lesions of the gastric mucosa, dyspepsia.

  The drug is not intended for the treatment of children and adolescents.

  Does not slow down the rate of reactions, therefore, there are no restrictions on driving vehicles / mechanisms during its use.

  What can replace Cardiomagnet?

  Analogues of Cardiomagnyl by ATC code, composition of active ingredients and release form: Acard, Asatsil-A, Aspeter, Aspirin Cardio, Acetylsalicylic acid, Magnikore, Thrombotic ACC, Thrombolic Cardio, Trombogard, Ecorin.

  Analogs of the drug with a similar mechanism of action: Avix, Agrenox, Aspigrel, Brilinta, Vasotik, Monofram, Deplatt, Zylt, Ipaton, Clopidogrel, Klopilet, Lopigrol, Myogrel, Plavigrel, Plavix, Trombex, Effient.

  The price of Cardiomagnyl analogues is from 8 rubles.

  Which is better: Cardiomagnet or Tromboass?

  Thrombo ACC tablets are NSAIDs that are used to prevent stroke, heart attack, deep vein thrombosis, thromboembolism and a number of other pathological conditions. The basis of the drug - acetylsalicylic acid.

  The principle of action of Cardiomagnyl and its analogue is based on the ability of ASA to block the synthesis of thromboxane and Pg, which helps to reduce aggregation and adhesion platelets as well as reducing inflammation.

  In addition, both drugs reduce K-dependent coagulation factors and increase plasma activity.

  The main differences between Cardiomagnet and its substitute: composition and form of release. Thrombo ACC tablets contain 50 or 100 mg of ASA, and magnesium hydroxide is absent. To minimize the negative effect of ASA tablets are covered with a special enteric protective shell.

  Patients leave approximately the same reviews about the drugs, but Thrombo ACC, in their subjective opinion, causes unwanted side reactions somewhat less often.

  Acecardol and Cardiomagnet - differences

  Acecardol is a drug, the active ingredient of which is also ASA. Its differences from Cardiomagnyl are the absence of magnesium hydroxide in the composition, the release form (tablets in a to / r shell) and the dosage of ASA (50/100/300 mg / tab.).

  Which is better: Cardiomagnet or Aspirin Cardio?

  Aspirin Cardio is the original drug from Bayer AG. The tool belongs to the ASA group of drugs with the greatest evidence base. Thanks to a special enteric coating, its active substance is released not in the stomach, but in the intestinal tract, therefore, Aspirin Cardio is better tolerated by patients than usual acetylsalicylic acid.

  Tablets are available in a calendar package, which allows you to improve the control of the patient's implementation of the treatment prescribed by the doctor.

  Alcohol compatibility

  With the simultaneous intake of alcohol and ASA, an additive effect is observed.

  Cardiomagnet during pregnancy

  In the 1st trimester, taking high doses of salicylates is associated with an increased incidence of fetal defects.

  In the 2nd trimester, drugs of this group are used taking into account the therapeutic effect for the mother's body and the potential risks for the unborn child.

  In the last 3 months of pregnancy, salicylates are contraindicated. In the 3rd trimester, high doses of ASA can cause inhibition of labor, increased bleeding (both in the mother and in the fetus), and premature closure of the botalle duct in the fetus.

  The use of ASA immediately before childbirth can provoke hemorrhagic cerebrovascular accident(especially in premature babies).

  Salicylates and their metabolic products pass into breast milk. Accidental intake of a small dose of ASA during lactation does not require termination of breastfeeding and is not accompanied by the development of undesirable effects in the child. However, high doses or long-term use of these drugs requires discontinuation of hepatitis B.