Structure

Active substance: Salbutamola Sulfate 120.5 μg in one dose (equivalent to 100 μg salbutamola).

Auxiliary substances: propellant GR106642X (1,1,1,2-tetrafluoroethane, also known as HFA 134a or Norflouran). Does not contain chlorofluorocarbon phones.

Description

Metal inhaler with an indulged bottom, equipped with a dosing valve containing a suspension of white or almost white. There should be no damage on the inner surface of the inhaler.

Pharmacotherapeutic group

Means for the treatment of obstructive diseases of the respiratory tract. Adrenergic means for inhalation. Selective beta-2-adrenoreceptor agonists.

The codeATH:R03ac02.

Pharmacological properties

Pharmacodynamics

Salbutamol is a selective agonist of beta-2-adrenoreceptor.

After the inhalation use, Salbutamol has a stimulating effect on the Beta-2-adrenoreceptors of the smooth muscles of the bronchi, thus providing quick bright browsection, which manifests itself in a few minutes and is preserved for 4-6 hours.

Pharmacokinetics

Salbutamol.

After the inhalation administration of the drug, its concentration in the blood plasma when taking ordinary doses is minor (10-50 times less than when administering the drug orally or by injection).

The relationship between the level of concentration in the blood and the effectiveness is absent. After pulmonary resorption, the drug is excreted mainly by the kidneys, partly unchanged (less than 2%), partly - in the form of inactive metabolites (phenolic sulfates).

1,1,1,2 - tetrafluoroethan: Obesting gas

After the inhalation administration of the drug, the adsorption of 1,1,1,2-tetrafluoroethane is insignificant and fast, the maximum concentration is achieved less than in 6 minutes.

In animals (mice and rats) there was a minor liver metabolism of the drug with the formation of trifluoroacetic acid and trifluoroacetic aldehyde. Nevertheless, according to the results of kinetic studies conducted among patients receiving 1,1,1,2-tetrafluoroethane in the presence of pathologies, cases of formation of trifluoroacetic acid were not detected.

Indications for use

Symptomatic treatment of attacks bronchial asthma.

Symptomatic treatment of exacerbations of bronchial asthma or chronic obstructive bronchitis.

Preventing asthma attacks caused by exercise.

Test for the reversibility of bronchial obstruction during the functional studies of the respiratory tract.

Contraindications

Allergic reaction to one of the components of the drug.

The intolerance to this medicinal product (the unexpected appearance of cough or the development of bronchospasm immediately after receiving the drug). In this case, it is necessary to discontinue treatment and assign other therapy or other methods of application.

Application during pregnancy and lactation

Pregnancy

Salbutamol.

IN clinical practice There is a sufficient amount of documented examples of the use of the drug during pregnancy, which allows you to conclude about the safe use of salbutamola during pregnancy.

Consequently, the use of salbutamol during pregnancy by inhalation administration is permissible.

When taking the drug during pregnancy:

A fetal heartbeat may be observed against the mother's tachycardia. In exceptional cases, the stupid heartbeat after birth is noted.

Similarly, in exceptional cases, a postnatal change in the level of glycemia is noted.

In the case of drug intake to childbirth, the vasodilator peripheral effect of beta-2-mimetics should be taken into account.

1,1,1,2 - tetrafluoroethan: Obesting gas

Reproductive function studies conducted on animals did not reveal the harmful effects caused by a reception of 1,1,1,2-tetrafluoroethane, which is contained in this drug.

Nevertheless, the consequences of the reception of 1,1,2-tetrafluoroethane in pregnant women are not installed.

Lactation

Beta-2-mimetics penetrate into breast milk.

The fact of penetration of the displacing gas and its metabolites into breast milk during the receipt of the drug is not installed.

Fertility

Information about the influence of Salbutamola on fertility in humans is missing. In preclinical studies of undesirable influence on fertility, animals were not identified.

Method of application and dose

Dosage

Regardless of age:

Treatment of attacks and aggravations of bronchial asthma: when the first symptoms appear to make 1-2 inhalations.

Prevention of asthma attacks caused by exercise: 1-2 inhalations 15-30 minutes before the start of physical activity.

In general, the dose of 1-2 inhalation is sufficient to treat breathing difficulties.

In the case of stability of symptoms, the dose can be repeated in a few minutes.

The duration of the bridal action of salbutamol during inhalation administration ranges from 4 to 6 hours.

When repeated occurrence Symptoms Reception of the drug can be repeated.

Usually daily dose The drug should not exceed 8 inhalations within 24 hours. If this dose is exceeded, the patient should be informed about the need for medical consultation in order to revise the indications for use (see the section "Precautions").

In the event of a severe acute attack of asthma or severe exacerbation of chronic obstructive bronchopneumopathy, the dose of the drug ranges from 2 to 6 inhalations, which should be repeated every 5-10 minutes before the arrival of emergency professionals medical care. In such situations, the use of an inhalation chamber is recommended, since it contributes to the acceleration of the pulmonary diffusion of salbutamola adopted by inhalation. However, repeatedly pressing the dosage inhaler and the release of doses into the inhalation chamber can shorten the total inhaled dose, and the patient must inhale the drug directly (or, if necessary, after each series of two consecutive clicks) from the inhaler after each pressing on the inhaler. In the future, the reception of the drug should be repeated by sequential cycles. A severe acute attack of bronchial asthma requires hospitalization. In this case, treatment is to carry out oxygen therapy and systemic therapy with corticosteroids.

Mode of application

Inhalation administration using a device in the form of a hermetic spray equipped with mouthpiece.

In order to correctly use the device, the doctor is recommended to make sure that the patient uses the inhaler correctly.

In the case of the patient, there is no synchronization of inhalation and pressing the inhaler, the use of an inhalation chamber is shown. Also in such patients it is possible to use other more adapted species dosage forms Salbutamola.

In children and infants who need to treat a suspension for inhalations salbutamol in the form of an aerosol, it is advisable to use an inhalation chamber equipped with a spacer.

The inhaler is not equipped with a dose counter.

Side effect

Unwanted reactions are listed depending on the anatomy-physiological classification and frequency of occurrence, which is defined as follows: Very often (≥ 1/10), often (≥ 1/100 and

* Beta-2-mimetics in elevated doses can cause reversible hyperglycemia and hypokalemia during the cessation of treatment.

** The frequency of the myocardium ischemia is not possible, since it was reported in spontaneous reports obtained during post-paying surveillance.

*** As with the use of other drugs for inhalation therapy, there is a possibility of cough and, in rare cases, paradoxical bronchospasm immediately after inhalation. It is recommended to stop taking this medicinal product and use another equivalent bronchottizer of quick action to facilitate bronchospasm. In the future, it is recommended to reconsider treatment to assign alternative therapy if necessary.

Extremely rare cases of lactatacidosis in patients taking salbutamol intravenously either by inhalation administration using a nebulizer in the treatment of severe exacerbation of bronchial asthma were noted.

Digestion (nausea, vomiting) can also be noted.

Informing about possible side effects

The provision of information on suspected adverse reactions identified after registration is of great importance, as it makes it possible to conduct continuous monitoring of the benefit balance and risk of drugs. Report any suspected adverse reactions of health care specialists can through a national system of informing.

Overdose

The symptoms and symptoms of the overdose of salbutamol are transient phenomena expressed in strengthening the pharmacodynamic effect of beta-2-agonists (see Sections "Precautions" and "Sidey").

The consequence of the overdose of Salbutamola may be hypocalemia. Therefore, in the event of an overdose, control of the concentration of potassium in serum is necessary.

Cases of nausea, vomiting and hyperglycemia were noted mainly in children and in cases where an overdose was due to oral administration of salbutamola.

Cases of lactatacidosis were noted when receiving elevated doses of beta-2-agonists of quick action. Consequently, under overdose, it is necessary to control the concentration of lactate in the blood of the blood, as well as the risk of lactatacidosis, in particular, in the case of stability or the deterioration of Tahipne, despite the disappearance of such symptoms of bronchospasm as a whistling breath, which may be associated with the development of metabolic acidosis.

Required actions: observation and symptomatic treatment.

Interaction with other drugs

+ Non-selective beta blockers

+ Halogen preparations for anesthesia (galotan)

When conducting obstetric surgical operations, an increase in the inertia of the uterus with the risk of bleeding was noted; In addition, there is a risk of developing serious ventricular arrhythmias when improving cardiac reactivity.

Combinations requiring compliance with precautions when used

+ Antidiabetic drugs

The reception of beta-2 mimetics is combined with an increase in glycemia, which can be interpreted as a decrease in the effect of antidiabetic therapy, therefore, it may be necessary to change anti-diabetic therapy (see section "Precautions"). Advanced control of blood and urine condition is recommended.

Precautions

special instructions

Inform the patient about the need to immediately appeal for medical assistance in the event that the previously observed facilitation of the state occurs in the development of the attack of bronchial asthma.

Increasing the need for the use of broutine, in particular beta-2-agonists, may be a sign of the exacerbation of bronchial asthma or obstructive bronchopneumopathy. If within a few days the needs of the patient in the consumption of beta-2-mimetic bronchodulators for a long and short action By inhalation administration, it has increased significantly, it is necessary (especially if the peak values \u200b\u200bof the flow meter are reduced and / or become irregular) breathing decompensation, and asthmatics are the possibility of developing asthmatic status. Consequently, the doctor must inform the patient about the need to immediately appeal in a similar case for medical care without intentional exceeding the maximum prescribed doses. In such a situation, it is necessary to revise indications for use.

A sudden and progressive aggravation of the flow of bronchial asthma may be dangerous for life. In such a situation, it is necessary to provide therapy with corticosteroids or an increase in the dosages of existing therapy with corticosteroids. In addition, in adult patients suffering from asthma, inhalation therapy with corticosteroids should be carried out in the case when the use of mimetic beta-2-agonists is more often 1 time per week. In this case, it is necessary to inform the patient that the improvement of its clinical condition should not be a consequence of changes in therapy, in particular, the cessation of inhalation corticosteroids without a medical detention.

As with the use of other drugs for inhalation therapy, immediately after the use of the drug can develop paradoxical bronchospasm, which is manifested in a more pronounced breathing and strengthening wheezing. Bronchospasm requires the treatment of an alternative form of release of the drug or another bronchoditator for inhalation therapy (if available). The use of the drug Salbutamol inhalation should be immediately terminated and, if necessary, assign another high-speed broutine to continue treatment.

Drugs with sympathomimetic effects, to which salbutamol relates, can cause violations of the cardiovascular system. According to the data obtained during the previous period of the use of the drug, as well as in the literature, cases of the development of myocardial ischemia associated with the use of Salbutamola were noted. Patients with severe cardiopathiopathy of the underlying departments (for example, IBS, arrhythmia or severe heart failure) should be informed about the need to appeal to the attending physician in case of pain in chest Or other symptoms indicating the exacerbation of heart disease. Attention should be paid to the assessment of such symptoms such as shortness of breath and pain in the chest, which can be a consequence of both heart disease and diseases of the respiratory system.

Precautions when using

In the case of bronchial infection or abundant bronchio breed, it is necessary to carry out appropriate treatment, which contributes to the optimal diffusion of the drug in respiratory tract.

Salbutamol should be appointed with caution to patients receiving significant doses of other sympathomimetic drugs.

Receiving salbutamola in conventional doses by inhaled administration using the device in the form of a hermetic can usually cause adverse Reactions In patients suffering from hyperthyroidism, disorders of coronary circulation, obstructive cardiomyopathy, ventricular arrhythmia, arterial hypertension, diabetesIn contrast to salbutamola, the reception of which is carried out with the help of a nebulizer orally or by injection, which should be appointed with caution to such patients.

Therapy of beta-2-mimetics in elevated doses (especially when administered by parenterally or with a nebulizer) can lead to potentially severe hypokalemia, which can cause violations heart Rhythm. In such cases, it is recommended to control the level of potassium in serum, in particular, while using xanthine derivatives, GKS, diuretics, due to hypoxia, as well as in patients with high risk of developing arrhythmia type "Pirouette" (the elongated Qt interval or therapy, capable of lengthening the interval Qt).

Like other beta-2-agonists of adrenoreceptors, Salbutamol can cause an increase in blood glucose. In patients suffering from diabetes, cases of ketoacidosis were noted. The concomitant use of corticosteroids can strengthen this effect.

Extremely rare cases of lactatacidosis associated with the use of increased doses of beta-2-agonists of short-acting, intravenously either by inhalation using a nebulizer, were noted mainly in patients undergoing therapy to relieve Bronchial Asthma exacerbation (see Side Action "). The increase in the content of lactic acid can cause difficulty breathing or compensating hyperventilation, which may be incorrectly interpreted as a sign of unsuccessful treatment of asthma due to an inappropriate increase in the dosage of beta-agonists of short-acting. Consequently, the risk of lactatacidosis should be an object of close observation, especially in severe cases.

Athletes:

Athletes should take into account that this medicinal product contains active substancewhich can show positive results when conducting anti-doping control tests.

Impact on the ability to drive a car and / or other mechanisms

There is no data.

Form release

200 doses to an aluminum inhaler equipped with a plastic dosing device with a protective cap. The inhaler and the dosing device in the assembled form along with the application instructions are placed in a cardboard pack.

FROMrocksucidity

2 years. Do not apply after the expiration date indicated on the package.

Storage conditions

At a temperature not higher than 30 ° C, do not freeze, prevent the effects of sun rays. Keep out of the reach of children.

Like most other inhalers in aerosol packages, salbutamol can be less effective at low temperatures. When cooling the canopy, it is recommended to get it from a plastic case and warm your hands for a few minutes. Caller cannot be disassembled, piercing and throwing into the fire, even if it is empty.

Conditions of vacation from pharmacies

On prescription.

Manufacturer

Legal address of the manufacturer:

Glaxo WELLOME PRODUCTION, FRANCE

23 RUE LAVOISIER - ZONE INDUSTRIELLE NO 2, EVREUX, FRANCE /

Glaxo Lelkom Production, France

Industrial Zone 2, Ryu Lavoisier 23, Evro, France.

For more information, contact the address:

Representation LLC "GlaxosmithKline Export Limited" (United Kingdom) in the Republic of Belarus

Minsk, ul. Voronoyansky, 7a, office 400

Tel.: +375 17 213 20 16; Fax + 375 17 213 18 66

Instructions for the use of inhaler

Check inhaler

Before the first use of the inhaler or in the event that the inhaler did not use 5 days and longer, remove the cap from the mouthpiece, slightly squeezing the cap from the sides, shake the inhaler well and click on the aerosol valve to release two inhalation doses into the air to make sure the inhale fee .

Using inhaler

Remove the cap from the mouthpiece, slightly squeezing the cap from the sides.

Inspect the mouthpiece from the inside and outside to make sure it is clean and does not contain extraneous particles.

Shake the inhaler well for uniform mixing the contents and to remove foreign particles.

Keep the inhaler between the index and thumb in vertical position bottom up thumb Must be located on the basis of the mouthpiece.

Make a slow deep exhalation, graze mouthpiece with lips, without squeezing his teeth.

Making a deep breath through the mouth, simultaneously press the upper part of the inhaler to release a single inhalation dose of salbutamola.

Hold the breath for a few seconds, remove the mouthpiece from the mouth, then slowly exhale.

To obtain a second dose, keeping the inhaler in a vertical position, wait about 30 s and then repeat step 3-7.

Tightly close the mouthpiece with a protective cap.

Attention! Performing stage 5, 6 and 7, you can not hurry. It should be inhaled as slowly as possible, immediately before pressing the inhaler valve. In the first few times it is recommended to practice in front of the mirror. If you see "fog", leaving the top of the inhaler or from the corners of the mouth, then you should start all over again from stage 3.

If the doctor gave you other instructions for using the inhaler, then keep them strictly. Contact your doctor if you have difficulty using the inhaler.

Cleaning inhaler

The inhaler must be cleaned at least once a week.

Remove the metal sprinkler from the plastic case and remove the mouthpiece cover.

Thoroughly rinse the plastic housing and the mouthpiece cover under the jet of warm water.

Dry the plastic housing and the mouthpiece cover is completely both outside and inside. Do not overheat.

Place the metal spray cylinder in the plastic case and wear the mouthpiece cover.

Do not immerse the metal balloon in the water.

The rights to possess trademarks belong to the group of companies GSK.

© 2018 GSK Group of Companies or their right holder.

Salbutamol Instructions for the use of which gives detailed instructions to use the drug, is a means appointed to relieve spasm in bronchi in the event of a choking. The peculiarity of the drug is that it is allowed to apply salbutamol during pregnancy and during lactation. Treatment of bronchial asthma - the process is long and even permanent. This is due to the fact that bronchial asthma is rated by diseases incurable, caused by many negative factors.

Will tell about how to use Salbutamol, instructions for use this drug. It describes all its advantages and features of the medicine. You should know by purchasing salbutamol that the form of release of this drug provides for an application in the form of an aerosol. The substance that has an active action is salbutamol in the dosage of 0.0725 mg per 100 mg of the drug. Salbutamol is one of the drugs, of which a group of synthetic tools created to combat asthmatic attacks, provide emergency medical care and preventing the development of suffocation.

As an additional component, oleate was introduced as an additional component, the dosage of which is 0.1449 mg for every 100 mg of the preparation. When creating salbutamola aerosol, intended for inhalations in the treatment of asthma, fluorrichloromethane and diefluorodichloromethane are used.

In the instructions written in Salbutamol, it is said that this drug is used to provide emergency medical care in complicing the attack of bronchial asthma.

• crouching churning;
• getting rid of spasm smooth muscles of the trunk and branches of the bronchial tree;
• preventing asthmatic seizures.

There are other forms of release. medicinal preparationwhich are in high demand in the elimination of asthmatic suffocation and prevent the development of a re-attack of asthma.

• oral application of salbutamol tablets;
• the use of salbutola aerosol for inhalation during an asthmatic suffocation;
• spray;
• syrup;
• capsules inside which is a powder intended for inhalation using a nebulizer;
• concentrate in bottles from which a solution for injection is prepared;
• the use of salbutamola for inhalation using special equipment or devices, to stop or prevent the development of an asthma attack. You can use a conventional inhaler or nebulizer at home.

In the course of the therapeutic measures under the hospital, the use of salbutamol medication produced in the form of a solution for intravenous invasions is possible. It is a salbutamol with a drug that is characterized by a mercolytic, and the pharmacology and composition of this drug speaks about the possibility of using the drug as a medicine with an anti-inflammatory effect.

With bronchial asthma, manufacturers recommend applying an inhalation aerosol, since this bright agent is characterized by a tocolic effect and contributes to the expansion of the bronchi, increasing the lumen of the respiratory tract and facilitating the patient's breathing. The composition of the drug, its group affiliation and pharmacodynamics confirm that Salbutamol quickly and effectively stop the attack of asthma, helps to deal with inflammatory process, developing in respiratory tract due to abundant allocation and accumulation of mucus.

• an increase in lung life capacity;
• expansion coronary arteries without change arterial pressure;
• preventing the allocation of histamine.

Directly pharmachologic effect The drug begins after 3-5 minutes after entering the active component (active ingredient) into the patient's body.

The mechanism of action is associated with the peculiarities of the influence on the beta2-adrenoreceptors of the smooth muscles of the bronchi, as a result of which the muscles of the respiratory organs relax and the lumen of the trunk and branches of the bronchial tree is expanding. Part of the dose of medicine adopted by patients during inhalation when an asthma attack occurs directly in the respiratory tract and lung patient, providing local action Depending on where the focus of inflammation is located and the place of narrowing the lumen of the bronchi.

In addition, under the influence of salbutamola, the allocation and removal of mucus from the respiratory organs is activated, the work of the fiscal epithelium is improved, which prevents the development of asthma attack due to contact with the allergen.

The use of salbutamola solution for inhalation is distinguished by special efficiency during the fight against asthmatic suffocation. The inhaler is a cylinder made of aluminum, equipped with a special valve and dispenser, when pressed for which medicinal composition is sprayed. Manufacturers produce designed and created for salbutul analogs in the form of capsules with powder powder for inhalation, tablets, syrup or spray.

Solving than replacing Salbutamol, it is necessary to consult with the attending physician. Otherwise the proper result may not be, but side effects Instantly let yourself know.

The use of salbutamola is possible strictly to appoint a doctor. The substances included in its composition are not always useful to patients in need of an urgent stopping attack of asthma. Annotation says that often hormonal drug With incorrect reception, it is addictive.

1. Diagnosed obstructive bronchitis in young children.
2. Prevention and relieving spasm in bronchi with all the forms of bronchial asthma.
3. The narrowing of the lumen of the bronchi or their blockage.
4. Chronic obstructive bronchitis in adults.
5. Emphysema of the lungs.
6. Bronchitis caused by asthma.

Listing the testimony for the use of Salbutamola, you can call the suddenly starting suffocation against the background of premature birth.

Many doctors argue that the use of Salbutamola in the first trimester of pregnancy entails a change in a certain level of hormone content, which becomes the cause of violation of the physiological course of pregnancy.

There are certain rules for the reception of the drug in the form of tablets, syrup or spray, use for inhalation nebulizer or intravenous administration.

Existing contraindications to the use of Salbutola say that with extreme caution, you should use this medicine to patients with hyperglycemia, but the absolute indication for receiving the drug is:

• violations of the functionality of the organs of the cardiovascular system;
• increased sensitivity or individual intolerance to the components of the drug components;
• congenital or acquired heart rate;
• ischemic disease;
• renal and liver failure;
• stenosis of the mouth of aorta;
• strokes;
• myocardial infarction;
• disorders of the functionality of the thyroid gland;
• glaucoma;
• epilepsy;
• pregnancy.

• hypertensive disease;
• arrhythmias;
• tachycardia;
• heart failure;
• Based disease.

1. Intrauterine death of the fetus or diagnosed frozen pregnancy.
2. Disorders of the development or prepayment of the placenta.
3. Suspicious of a possible detachment of the placenta.
4. Late toxicosis (swelling, violation of the functionality of the kidneys).
5. Uterine bleeding.

Appearance side Effects After applying the drug, it may be the consequence of the overdose of salbutamola or incorrect drug intake. To use such a device as an inhaler is necessary in strict accordance with the attached instruction. There is no reason for the appearance of side effects only an aerosol for inhalations. In other cases, the excess of the dosage indicated in the annotation leads to a violation of the heart rhythm and other difficult consequences.

1. When the drug is introduced inhalation, a burn or the reaction of irritation of the mucous pharynx is possible. The reason is exceeded maximum dose drug. Correctly dosed reception does not violate the normal state of the mucous.
2. An exceeded dose of salbutamol causes a heart rate impaired (arrhythmia) or causes a rapid heartbeat (tachycardia). Against the background of improper reception of the drug it is possible to expand the peripheral blood vessels.
3. Often a large daily dose can cause tremor limbs, the appearance of anxiety and unjustified fear, overexcitation, strong headaches.
4. If you are improperly using such devices as an inhaler or nebulizer, it is possible to exceed the allowable dosage, and medicinal composition causes convulsions in the limbs.
5. If the expiration date of the drug has expired, the instruction is violated, in accordance with which the substance should be used, or the composition is used uncontrollably, the level of potassium potassium is sharply reduced and pronounced metabolism develops.

Pretty rarely manifest allergic reactionsThe development of which is capable of provoking the approximate Salbutamola.

Their manifestation is associated with the gloomy, rash on the skin, itching, insignificant burning. Any manifestation of a negative response to the drug is an indication to the termination of therapy with its help.

Before proceeding with the treatment of salbutomol, it is necessary to make sure that there are no contraindications and compatibility of this medication with other substances used. The interaction of salbutamola with diuretic drugs leads to the development of hypokalemia, and with simultaneous admission with the means of breathing, tachycardia may appear and the heart rate disruption.

In such cases, the reception of Salbutamola should be immediately discontinued, but only a qualified doctor is capable of choosing a substitute. Completely incompatible with Salbutotol, bad habits, such as smoking and alcohol. Contraindication is also 1 trimester of pregnancy, when there is no placental barrier and the drug components can cause harm to the emerging fetus.

The method of using salbutamola 100 μg is an aerosol appointed by children before the upcoming physical activity.

1. For children, there is syrup, the reception of which several times a day is strictly dosed and is carried out under the strict control of physicians. How many times a day can be taken salbutul syrup and which dosage is used by a small patient depends on its age, weight and severity of the disease. When developing suffocation during an attack of asthma, children are allowed to use the aerosol. Turning over the inhaler upside down, holding it strictly vertically, the mouthpiece in the oral cavity is introduced and covered with his lips, not biting, not to damage. To buy an attack, it is enough to make two pressures with simultaneous breaths. Helped the procedure or not, it will be possible to understand when the effect of the drug will begin, and therefore, no later than 5 minutes later. If there is no effect, the procedure can be repeated. Important condition is an proper execution Procedures. Before spraying an aerosol, the child needs to make a complete exhalation, freeing the lungs from the air, and then a deep slow breath with simultaneously pressing the dispenser valve.
2. In the early periods of pregnancy, Salbutamol cannot be carried out on therapy, but if the woman enjoyed this medicinal composition after a placental barrier was formed, applying a inhaler several times a day, nothing threatens. Often, doctors do not recommend applying spray due to its antispasmodic action, fearing the negative impact on the muscles of the uterus, but if the risk for the health of the fetus and the full development does not exist, then the treatment of this drug is not contraindicated to a pregnant woman.
3. The number of inhalations per day is determined by the severity of the condition of the patient and the level of the upcoming exercise Or possible contact with an allergen. If the patient has to make significant efforts to perform certain actions, it is shown to receive two doses (200 μg). These are two inhalations or two pages on the dispenser.
4. Supporting therapy for chronic bronchitis lies in regular inhalations. This is 400 μg during the day, divided into 4 inhalations. After the procedure, for some time you should refuse to receive liquid and food.

The choice of the appointed dosage depends on the age of the patient. Children under 12 recommended a reception of 100 μg per day. Teenagers and senior patients are 200 μg as a single dose. The drug has an action for a short time, and with its help you can quickly stop the attack of an asthmatic choking.

For high levels The risk of contact with the allergen requires the prophylactic dose of salbutamola, but in cases where the medicine is used as a prophylactic agent with the possibility of developing the attack of choking, the patient takes 2 doses (2 inhalations) simultaneously. This means that he needs to shake the inhaler, turn it down by the dispenser and introduce the mouthpiece into the oral cavity.

The procedure cannot be performed with filled with light, since the drug makeup should penetrate the most distant corners of the lungs. To do this, you will need to make a complete exhale, then slowly breathing air, click on the cap of the dispenser and delay the breathing for 30 seconds. Can be repeated inhalation with a strong attack or in the absence of therapeutic effect. It is necessary to wait at least 5 minutes. It is important to remember that the premature repetition of inhalation can cause the manifestation of side effects.

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MNN: Salbutamol.

Manufacturer: Laboratories Aldo-Yunion S.A.

Anatomy-therapeutic-chemical classification: Salbutamol

Registration number in Kazakhstan: No. RK-LS-5№019225

Registration period: 15.02.2018 - 15.02.2023

KNF (LS Included in the Kazakhstan National Medicinal Form)

Alo (included in the list of free outpatient medicinal support)

UG (included in the LS List in the GBCM, to be purchased from the Unified Distributor)

Instruction

Tradename

Salbutamol.

International non-proprietary title

Salbutamol.

Dosage form

Inhalation aerosol, metered, 100 μg / dose, 200 doses

Structure

One dose contains

active substance -salbutamola sulfate 120.5 μg (equivalent to salbutamol 100 μg),

excipients: Tetrafluoroethane, oleinic acid, ethanol.

Description

Uniform white suspension

Pharmacotherapeutic group

Preparations for the treatment of obstructive diseases of the respiratory tract. Beta 2-adrenostimulants selective.

Code ATHR03AC02.

Pharmacological properties

Pharmacokinetics

After inhalation, about 10-20% of the active substance reaches small bronchi, the rest of the amount settles in the upper respiratory departments. When taking inside, including with partial swallowing during inhalation, salbutamol is well absorbed from the gastrointestinal tract. Pressure metabolism of salbutamola occurs mainly in gastrointestinal By conjugation with ester of inactive sulfate. Due to the gradual absorption of bronchi, systemic levels of salbutamola are low after the inhalation of the recommended dose. The maximum plasma concentrations are achieved in 2-4 hours. Communication with plasma proteins - 10%. Penetrates the placenta. Salbutamola's system clearance is 30 liters / hour. Salbutamol is removed with urine unchanged and in the form of a phenalsulfate metabolite. The half-life ranges from 3 to 7 hours. Approximately 72% of the dose is derived from the urine for 24 hours and consists of 28% of the unchanged preparation and 44% of metabolite. Salbutamol does not pass through the hematostephalic barrier.

Pharmacodynamics

Salbutamol is a selective β2-adrenoreceptor agonist. In therapeutic doses, it stimulates the β2-adrenoreceptors of the smooth muscles of the bronchi, having a minor effect or at all without affecting β1-adrenoreceptors. It has an armored effect, warning or binding bronchial spasms, increases the life capacity of the lungs, reduces resistance in the respiratory tract. Thus, salbutamol has a rapid broncholy action, which lasts for 4-6 hours.

In recommended therapeutic doses does not have negative influence On the cardiovascular system, it does not cause an increase in blood pressure. To a lesser extent compared to drugs This group has a positive chrono and inotropic effect. Causes the expansion of the coronary arteries.

It has a number of metabolic effects: reduces plasma potassium concentration, affects glycogenolysis and insulin selection, hyperglycemic (especially in patients with bronchial asthma) and a lipolytic effect increases the risk of acidosis.

Indications for use

Symptomatic treatment of bronchospasm, bronchial asthma and / or reversible respiratory tract

Prevention of bronchospasm caused by exercise or in situations of the inevitable effects of allergen

Method of application and dose

It applies only inhalation in accordance with the recommendations of the doctor. Salbutamol can be used with the spacer patients who are difficult to synchronize the dose of aerosol with a breath.

Adults (including elderly patients)

To stop the acute attack of bronchospasm and episodes of an intermittent asthma, 100 μg is used (1 inhalation). The dose can be increased to two inhalations, if necessary.

For the prevention of the attack of bronchospasm caused by physical activity or affected by the effects of allergen, 1 or 2 inhalations 10-15 minutes before the impact of the provoking factor.

Children: Recommended dose for relief acute symptoms Asthma, including bronchospasm, or to the effects of allergen or exercise of 100 μg (1 ingulation). For the prevention of the attack - up to 100-200mkg (1-2 inhalation) 4 times a day. If the answer is inadequate, you can use more than one inhalation.

The bronchology effect after each application lasts at least 4 hours, except for patients who have asthma progresses. If you need to increase the dose or the use of systemic glucocorticosteroids, you should consult with your doctor.

The need to increase the dose indicates the progression of the disease.

Instructions for using inhaler

The effect of the drug can be loosened if the cold inhaler. When cooling the can, it is recommended to get it out of a plastic case and warm your hands for a few minutes. Caller cannot be disassembled, piercing and throwing into the fire, even if it is empty.

Checking the health of the inhaler

Carefully remove the lid from the mouthpiece, vigorously shake the inhaler and spray two doses of the drug into the air. If the inhaler has not been used for several days, shake well and spray one dose of the drug in the air to make sure.

The use of inhaler

A. Remove the protective cap from the inhaler mouthpiece. Check clean and dry Municipality.

B. Shake inhaler vigorously.

C. Place the inhaler vertically between big and index fingers, placing a thumb on the base below the mouthpiece.

D. Make a deep exhale. Then place the mouthpiece between the teeth (without biting it) and tightly clap her lips.

E. Make a deep breath through the mouth. Continuing to take a deep breath, press the upper part of the inhaler. Pressing the inhaler should be at the beginning of a calm, deep breath.

F. Hold your breath, remove the inhaler from the mouth and remove the index finger from the top of the inhaler. Continue to restore your breath as possible.

H. If you need to continue inhalation, you should wait approximately half a minute, keeping the inhaler vertically, and then repeat the steps from B by F. After inhalation, put on the mouthpiece dust caps.

The drug is applied to the appointment of a doctor and it is necessary to inform it about any difficulties associated with the reception of the drug.

Side effects

Side effects are listed below, based on the classification by frequency. Frequency classification: Very often (≥1 / 10), often (≥1 / 100, but<1/10), нечасто (≥1/1000, но <1/100), редко (≥1/10 000, но <1/1000) и очень редко (<1/10000).

Often

Tachycardia, Tremelor, Headache, Dizziness

Infrequently

Heartbeat, voltage feeling

Nausea, vomiting

Irritation of the mucous membrane of the oral cavity and pharynx, changing taste sensations

Muscular spasmod

Seldom

Hypokalemia, which can be potential for corticosteroids, diuretics and xanthines

Peripheral vasodiilation

Muscular cramps

Rarely

Hypersensitivity responses (angioedema edema, urticaria, bronchospasm, hypotension and collapse)

Paradoxical bronchospasm

Increased activity

Heart rhythm violation, cardiac arrhythmia, including flickering arrhythmia, atrial fibrillation, sugarynavricular tachycardia and extrasystolia, myocardial ischemia

Lactoacidosis

Drowsiness, fatigue, chest pain

As in the case of other types of inhalation treatment, paradoxical bronchospasm can occur with the immediate amplification of a whistling breathing after the use of the drug. Such a state should be eliminated using a rapid effect inhalation broutine from another pharmacological group. The use of the drug Salbutamol, 100 μg / dose must be immediately discontinued, an alternative treatment is appointed.

Contraindications

Hypersensitivity to any of the drug components

Children's age up to 2 years old when using inhaler without spacer

Medicinal interactions

Salbutamol is not recommended to take together with other sympathomometric broutine in the form of inhalation. If you need to use adrenergic drugs, care should be taken to avoid violation of cardiac activity.

Salbutamol cannot be taken together with non-selective beta-adrenobloclars (including eye-eye dosage forms of beta adrenoblockers). Parallel use of cardiolective beta-blockers does not reduce the Salbutamola effect. Simultaneous treatment with xanthine derivatives, diuretics and glucocorticosteroids can contribute to the development of serious hypokalemia. Also, together with Salbutotol, general anesthetics, tricyclic antidepressants and maprotilin, ergotamine and Mao inhibitors are impossible. In the case of the simultaneous use of salbutamola and heart glycosides, the risk of arrhythmia caused by hypokalemia due to the use of beta-agonists increases.

Patients should be prevented about the need to stop the use of salbutamola at least 6 hours before anesthesia using halogenated anesthetic agents.

special instructions

The drug should be used through fixed time intervals in accordance with the recommendations of the doctor. In case you have missed a dose, you need to apply the drug immediately as soon as you remember this, but never take two doses at once.

The frequent use of salbutamola can lead to an increase in bronchospasm, a sudden death, and therefore, between the receptions of the next doses of the drug, it is necessary to take breaks in several hours (6 hours) the reduction of these intervals can only take place in exceptional cases. When applying a dosage aerosol, a clear execution of the following instructions is necessary: \u200b\u200bShaking a spray with an aerosol before each use, clear synchronization of inhalation and drug receipt, the most deep, intense and sufficiently long breath, breathing delay after inhalation on 10 s. Patients, including young children who are difficult to correctly perform a breathing maneuver, it is recommended to use a special adaptation (spacer), increasing the breathing volume and smoothing inaccuracies asynchronous inhalation.

The treatment of asthma should usually follow the step program at which permanent clinical control is needed using the test of the function of the respiratory system.

Bronchodulators should not be the only or basic method of treating patients with asthma light persistent, moderate, severe and unstable. Heavy asthma requires constant medical control, since such patients are a great risk of severe asthmatic crisis or even death. In such cases, the attending physician should consider the possibility of appointing the maximum recommended dose or glucocorticoids in the form of inhalation or inside.

Increasing the need to use bronchodulators of short-term action in the form of inhalation to relieve symptoms, indicates the weakening of control over the asthmatic disease. The patient must be warned that in case the bright-acting bright actors lose their effectiveness or requires more inhalations than usual, he should immediately report this to the doctor. In such cases, it is necessary to overestimate the treatment and consider the possibility of appointing anti-inflammatory therapy (for example, glucocorticoids in the form of inhalations or a course of glucocorticoids inside).

A sudden and progressive deterioration of an asthmatic disease can threaten the patient's life, in this case it is necessary to consider the possibility of using corticosteroids. For patients, risk groups need to carry out daily control of the maximum volume of lungs.

In the event that the previously used dose of salbutamola in the form of inhalation will not be able to stop symptoms, at least for 3 hours, the patient is recommended to consult a doctor to make a decision on the use of additional measures.

To increase the effectiveness of the patient's therapy, it is necessary to use the proper use of the inhaler and at the beginning of treatment to apply an inhaler under the supervision of medical personnel.

Caution is prescribed salbutamol patients with thyrotoxicosis, heart failure, hypertension, aneurysm, violation of glucose tolerance, diabetes mellitus, feuhromocytoma, myocardial ischemia, tachycardia and hypertrophic obstructive cardiomyopathy and with cordial glycosides,

Patients with cardiovascular diseases, including history, for example, ischemic heart disease, arrhythmia or severe heart failure, when prescribing salbutamol, should be warned relative to the compulsory appeal to the doctor in case of pain in the chest or other symptoms of cordial exacerbation vascular disease. It is necessary to carefully evaluate the appearance of such symptoms as shortness of breath and pain in the chest, since they can be a consequence of both cardiovascular and bronchopal functional disorders.

The use of beta-2-adrenoreceptor agonists can cause potentially dangerous hypokalemia. Special caution should be observed in severe attacks of asthma, since this effect can be enhanced by the joint use of xanthine derivatives, steroids, diuretics and hypoxia. In such situations, it is recommended to regularly monitor serum potassium concentration levels.

Salbutamol and non-selective beta-adrenoblays should not be used together (pharmacological antagonism).

Salbutamol contains a component that can give a positive result when doping control.

Application by elderly patients

Dose adjustments are not required.

Children: The use of the drug should be under the supervision of an adult.

Pregnancy and lactation period

In some studies, polydacticity in children were revealed against mothers during the pregnancy of salbutamol (the unambiguous causal connection of its occurrence with the reception of the drug was not established). In experimental studies, the presence of a teratogenic effect at Salbutamola was found: in mice with n / k administration (dose, at 11.5-115 times higher than the maximum recommended person for inhalation administration) was noted the development of wolf pastes; In rabbits during oral administration (dose, 2315 times higher than the maximum for inhalation administration) - the unexpection of the bones of the skull. Adnergic bronchodulators can be used during pregnancy, since the potential risk of placental hypoxemia for the fetus against the background of uncontrolled bronchial asthma significantly exceeds the risk associated with their use. However, when they are used during pregnancy, caution should be taken, since adrenergic bronchodulators can cause tachycardia and hyperglycemia in the mother (especially in the presence of diabetes mellitus) and the fetus, and also cause a delay in the delay of generic activities, reduced blood pressure, lung swells. Applying salbutamol during pregnancy is recommended only in case of extreme necessity and when the expected benefits exceeds the potential risk to the fetus.

If it is necessary to use the drug during breastfeeding period, it is recommended to abandon breastfeeding.

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

It should be refracted from driving and working with the mechanisms of those patients, in which, especially at high doses, there are specific adverse reactions, especially at the beginning of treatment or with joint use with alcohol. When managing motor transport and working with mechanisms, caution should be taken due to the possibility of adverse reactions to Salbutamol, such as muscle cramps and tremor

Overdose

Symptoms: more frequent - hypokalemia, reduction of blood pressure, excitation, tachycardia, muscle tremor, nausea, vomiting; less frequent - hyperglycemia, respiratory alkalosis, hypoxemia, headache; Rare - hallucinations, cramps, tachyarhythmias, ventricular fluttering, expansion of peripheral vessels.

Treatment: Under the overdose of salbutamol, the best antidotees are cardiolective beta-adrenoblays. However, β-adrenoreceptor blockers must be used with caution due to the danger of bronchospasm. The use of large doses of salbutamola can cause hypocalemia, so when suspected overdose, the level of potassium in serum should be monitored and the deficiency of potassium oral preparations, with the exception of patients with severe hypokalemia, in which case intravenous administration of potassium preparations may be required.

Release form and packaging

The inhalation aerosol, dosage, 100 μg / dose, 200 doses are placed in an aluminum cylinder, equipped with a dosing valve, spray nozzle and a protective cap.

This article allows you to familiarize yourself with the instructions for the use of the drug. Salbutamol.. Reviews of site visitors - consumers of this medicine, as well as opinions of specialist doctors on the use of Salbutamola in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Salbutamola in the presence of available structural analogues. Use for the treatment of bronchial asthma and the relief of bronchospasm in adults, children, as well as during pregnancy and breastfeeding. Composition of the drug.

Salbutamol. - It is a selective antagonist of beta2-adrenoreceptors. In the therapeutic doses, it acts on the beta2-adrenoreceptors of the smooth muscles of the bronchi, providing a pronounced bronchhalytic effect, warns and stops bronchospasm, increases the life capacity of the lungs. Prevents the isolation of histamine, a slowly reacting substance from the fat cells and the factors of chemotaxis neutrophils. It causes a slight positive chrono and inotropic effect, expanding the coronary artery practically does not reduce blood pressure. Tocolytic action has: lowers the tone and the contractile activity of the myometrium.

It has a number of metabolic effects: reduces the potassium content in plasma, affects glycogenolysis and insulin allocation, has hyperglycemic (especially in patients with bronchial asthma) and a lipolytic effect, increases the risk of acidosis.

The effect of the drug begins 5 minutes after inhalation administration and continues for 4-6 hours.

Structure

Salbutamola sulfate + excipients.

Pharmacokinetics

After inhalation administration from 10 to 20%, the dose enters the respiratory tract. The rest of the part is delayed in the instrument or settles in the rotoglotka and then swallows. Part of the dose that remains in the respiratory tract is absorbed by the tissues of the lungs, without exposing the metabolism in the lungs, and enters the bloodstream. When entering the systemic blood flow, it can be metabolized in the liver and is excreted mainly with urine unchanged or in the form of phenolic sulfate. The degree of binding of salbutamola with plasma proteins is 10%. Part of the dose entered into the gastrointestinal tract is absorbed and subjected to intense metabolism during the "first passage" through the liver, turning into phenolic sulfate. The unchanged drug and conjugate are predominantly with urine. Most of the dose of salbutamola administered intravenously, inward or inhaled, is excreted within 72 hours.

Indications

• prevention and relief of bronchospasm with bronchial asthma, chronic obstructive diseases of the lungs (COPD), chronic bronchitis, lung emphysema.

Forms of release

Aerosol for inhalations dosed 100 μg (sometimes erroneously called spray).

Tablets 2 mg and 4 mg.

Instructions for use and dosage

Adults and children over 12 years old: 100-200 μg (1-2 inhalation doses) to relieve attacks of choking. For control over the stream of easy severity - 1-2 doses 1-4 times a day and the average severity of the disease - in the same dosage in combination with other anti-asthma drugs. For the prevention of asthma of physical effort - 20-30 minutes before the load of 1-2 doses on reception.

The daily dose should not exceed 800 μg (8 inhalation).

Instructions for using inhaler

Check the operation of the inhaler before its first use, and also if you did not use it for a while.

1. Remove the cap from the inhaler. Make sure that there is no dust and dirt on the output tube.
2. Keep a balloon in a vertical position, putting a thumb on the bottom, and the index finger is on the top of the cylinder.
3. Intensively shake up-down ballon.
4. Make as a deep exhalation (without voltage). Tightly clamp the lips the outlet tube of the canister.
5. Make a slow deep breath. At the moment of the inhalation, press the index finger on the cylinder valve, the dose of medication. Continue slowly inhale.
6. Remove the inhaler tube from the mouth and hold your breath for 10 seconds or as much as possible without tension. Exhale slowly.

If more than one dose of the medicine is required, wait approximately a minute and then repeat the steps, starting with the step 2. Near the cap on the inhaler.

When performing steps 3 and 4 do not rush. At the time of release, the dose of medicine is important to do inhale as slower. At the beginning, practice around the mirror. If you notice the steam coming out from the tip of the spray or from the angles of the mouth, then start from step 2 again.

Inhaler cleaning

Inhaler should be cleaned at least once a week. Remove the metal cylinder from the plastic case and alter the case and cap with warm water. Do not use hot water. Thoroughly dry, but do not use heating devices for this. Place the cylinder back into the case and put on the cap. Do not dip the metal cylinder into the water.

Side effect

• tremor fingers;
• headache;
• dizziness;
• increased excitability;
• anxiety;
• sleep disturbance;
• insomnia;
• expansion of peripheral vessels (hyperemia of the skin of the face);
• the appearance of pain in the chest;
• arthralgia;
• angioedema edema;
• hives;
• nasal congestion;
• bronchospasm;
• muscle cramps;
• nausea, vomiting;
• dyspepsia;
• cough;
• excitation and increase in motor activity in children;
• the appearance of arrhythmias (including atrial fibrillation, superstricular tachycardia and extrasystole).

Contraindications

• rhythm disorders (paroxysmal tachycardia, political ventricular extrasystole);
• myocarditis;
• heart defects;
• aortic stenosis;
• coronary artery disease;
• tahiaritimia;
• thyrotoxicosis;
• decompensated diabetes;
• glaucoma;
• epileptic seizures;
• pyloroduodenal narrowing;
• renal or liver failure;
• simultaneous reception of non-selective beta-adrenoblasts;
• pregnancy;
• children's age up to 2 years;
• increased sensitivity to any component of the drug.

Application in pregnancy and breastfeeding

Contraindicated in pregnancy.

During the lactation period, it is assigned only in cases where the expected benefit for the mother exceeds any possible risk for the child.

Application in children

Children from 2 to 12 years old: with the development of the attack of bronchial asthma, as well as to prevent the bronchial asthma attacks associated with the effects of allergen or the physical activity caused, the recommended dose is 100-200 μg (1 or 2 inhalation).

special instructions

In patients with severe or unstable bronchial asthma, the use of bronchodulators should not be the main or only method of therapy. If the action of a conventional dose Salamol Eco becomes less efficient or less long (the effect of the drug should be maintained at least 3 hours), the patient should consult a doctor.

Frequent use of salbutamola can lead to an increase in bronchospasm, sudden death, and therefore between the receptions of the next doses of the drug, it is necessary to take breaks in several hours.

Improving the need for the use of inhalation agonists of beta2-adrenoreceptors with a short duration of action to control the symptoms of bronchial asthma indicates the exacerbation of the disease. In such cases, the patient's treatment plan should be revised and to resolve the issue of appointing or increasing the dose of inhalation or systemic glucocorticosteroids (GKS).

Therapy by agonists of beta2-adrenoreceptors can lead to hypokalemia. It is recommended that it is recommended for particular caution in the treatment of severe bouts of bronchial asthma, since in these cases hypocalemia may increase as a result of the simultaneous use of xanthine derivatives, GKS, diuretics, as well as due to hypoxia. In such situations it is necessary to control the level of potassium in serum.

Cylinder with salbutolo cannot pour, disassemble or throw into the fire, even if it is empty. Like most other means for inhalations in aerosol packages, salbutamol can be less effective at low temperatures. When cooling the cylinder, it is recommended to get it from a plastic case and warm your hands for a few minutes.

To determine the reversibility of bronchial patency and evaluating the effectiveness of the therapy, samples with bronchoranty drugs (bronchodlatators) are used, such as salbutamol.

The drug contains ethanol (alcohol). This fact must be taken into account when driving a vehicle.

Medicinal interaction

Theophylline and other xanthines with simultaneous use with salbutomol increase the likelihood of tachyarithmiums; Means for inhalation anesthesia, levodopa - heavy ventricular arrhythmias.

Mao inhibitors and tricyclic antidepressants enhance the action of salbutamola and can lead to a sharp decrease in blood pressure.

Salbutamol enhances the effect of CNS stimulants, side effect of thyroid hormones, heart glycosides.

Reduces the effectiveness of hypotensive drugs, nitrates.

Hypocalemia can be intensified as a result of the simultaneous use of xanthine derivatives, GKS, diuretics.

Simultaneous purpose with anticholinergic agents (including inhalation) can contribute to an increase in intraocular pressure.

Analogs of the Medication Preparation Salbutamol

Structural analogues for the acting substance:

• Aloprol;
• Astalin;
• Ventolin;
• Ventolin Nebules;
• Volmax;
• Salamole;
• Salamol Eco;
• Salmo;
• Salben;
• Salbouvent;
• Salbutamol Teva;
• Salbutamola hemisuccinate;
• Salbutamol sulfate;
• Salgim;
• Saltos;
• Slerine Salamole;
• Cyclocaps cybutol.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

Content

In 1967, English scientists have developed a Salbutamol - a chemical compound capable of influencing the smooth muscles of the respiratory tract, uterus, affect the level of potassium in the blood. The broncholitic, created on its basis, belongs to the group of selective agonists of β2-adrenoreceptors - substances capable of influencing the adrenaline receptors sensitive to hormone. Today, salbutamol is the main means of therapy of the diseases of the respiratory tract.

Composition and form of release

The drug was created on the basis of salbutamol sulfate - easily dissolved water of white crystalline powder without odor. Dosage forms of broncholics Many - tablets of ordinary and prolonged action, syrup, aerosol, powder for inhalation, solution for inhalation, injection. Aerosol cylinders have a dosing valve and spray when pressed 1 dose (0.1 mg) drugs. The drug does not contain chlorofluorocarbon phones, its auxiliary substances are ethanol, hydrophorelkan, hydrofluorocarbon. The quantitative composition of different forms is given below:

Mechanism of action

Therapeutic doses of broncholics, stimulating β2-adrenoreceptors, have anti-inflammatory, musolitic (promotable sputum), bronchhalytic (relaxing bronchi muscles) effects. The use of salbutamola warns and stops bronchial spasms, including allergic and due to exercise, stimulates the production of mucus in the respiratory tract, enhances the respiratory function of the lungs.

The broncholytic agent has a tocolic effect - lowers the tone, reduces the contractile activity of the mineometry (muscle layer of the uterus), is used to prevent premature genera. It has a metabolic effect - it helps to reduce the concentration of potassium in the blood, the cleavage of glycogen to glucose, insulin secretion, blocking histamine factors, glycogenolysis (glycogen cleavage to glucose). Therapeutic doses do not have β1-adrenergic influence on the heart, pecked chemotaxis (activity) of bone marrow cells.

Any form of a substance is quickly absorbed by blood, metabolized by the liver, intestine. The circulation time of the substance along with blood can reach 9 hours. Removal of bronchospasm is faster at an inhalation method of administration. Increase the effect of broncholics can be introduced 2 doses, a further increase in the amount in the state of bronchial patency is not reflected, but contributes to the occurrence of side effects.

Prolonged tablets due to the gradual receipt of the active substance through the shell support the necessary therapeutic concentration in the plasma for 12-14 hours. After receiving non-prolonged dosage forms, the maximum effect is observed after 30 minutes, the action lasts when receiving:

• syrup - 2 hours;
• tablets - 2-4 h;
• injection mortar - 4-6 h.

Salbutamol - Hormonal drug or not

Many hormonal drugs are effective in the treatment of chronic diseases of the respiratory tract, which belongs to the bronchial asthma. They are analogues of natural steroid hormones produced by adrenal glands - cortisone and cortisol. The need for their purpose occurs when a launched progressive form of the disease.

Inhalers with hormones gradually slow down the development of the inflammatory process, reduce the frequency and severity of exacerbations. Salbutamol, at bronchitis, eliminates the already happening the attack of shortness of breath, relaxing the muscles of the bronchi stimulation of their receptors. The drug is a means of rapid, but short-term removal of spasm, refers to the discharge of bronchoditics, and not hormonal medicines.

Indications for use

The drug is used for diseases of the respiratory tract, accompanied by the spastic states of the bronchi, as the tocologists in gynecology and the means of normalizing the level of potassium in the blood. It effectively eliminates the symptoms arising or prevents their appearance, including in contact with provoking factors, with the following states:

• bronchial asthma of any etiology;
• chronical bronchitis;
• chronic obstructive pulmonary disease;
• the threat of premature births, accompanied by the contractile activity of the uterus;
• hypercalemia.

Method of application and dosage

The size of the prescribed dose depends on the age of the patient, the nature of the disease, the dosage form of the bronchology. The amount of active substance in tablets, solution for injection, syrup, aerosol is different, so the change of dosage form is possible only in coordination with the doctor. Salbutamol children 6-12 years old are shown in the amount of half a dose for an adult, the kids are 2-6 years old the amount of medication is selected individually. Optimal is the use of bronchophile on demand when attacking bronchospasm.

Salbutamol in tablets

Orally, the drug is taken to expand the bronchi in connection with the ineffectiveness of inhalation forms and in the threat of premature genera. Adults and children from 12 years are prescribed 1 tablet with an active substance content of 2 mg (with sharp forms of the disease - 4 mg) 3-4 times a day. Children 6-12 years old are shown a dose of 2 mg 3-4 times, 2-6 years - 1 mg 3 times a day. A special shell of a tablet of prolonged action with an 8 mg of an active substance is capable of gradually released it, providing the necessary concentration of it in the plasma for 12-14 hours.

As a tocolic agent for suppressing premature bages, 1 tablet is prescribed every 2-3 hours during the first day, then for 2 days - 1 tablet every 4 hours, then a few days before the complete cessation of the contractile activity of the uterine 1 tablet every 6 hours. With multiple pregnancy, the reception of the drug inside as the means of preventive tocolic therapy is ineffective.

Powder for inhalations

Salbutamol for inhalations in the form of powder is introduced using an individual portable disk inhaler - cyclohaler. If you need to stop the bouts of bronchial asthma, 1-2 doses of 200-400 μg are prescribed once, for the prevention of exacerbation - 1-2 doses 3-4 times a day depending on the intended degree of influence of the provocating factor. The maximum daily dose (800-1000 μg), if necessary, can be increased to 1200-1600 μg.

Spray can

The most convenient and frequently used form of the drug is an inhalation aerosol used by inhalation through the rotoglot. Before first use, the balloon should be shaken and perform one trial spraying into the air. For up to 4 years, inhalation is made through the intermediate tank - the spacer. An adult person requires 1-2 injection into the oral cavity, children are only one.

If the body's reactions 10 minutes after reception will not follow, it is allowed to be made 1 more injection, after which no longer use the medicine for 4-6 hours. The amount of doses during the day should be no more than 8. For the prevention of bronchospasm, 1-2 inhalations are used 15-30 minutes to physical exertion or the effects of allergen. With a weak perception of medication and exacerbation of the disease, the doctor can increase the dose.

special instructions

The use of β2-adrenoreceptor drugs with healthy people leads to the expansion of the bronchi and, as a result, an increase in physical stability, therefore, in professional sports, the use of a bronchological agent may be regarded as doping use. During treatment, alcohol use should be avoided. Both with long-term treatment with the drug, and with a sudden cancellation, the risk of complications arises.

The need for the use of broncholics should not be more than 4 times a day. An increase in the frequency of use may be a consequence of the aggravation of the disease, in this case it is recommended to revise approaches to its treatment. The frequent use of the bronchology can lead to an increase in bronchospasm and even a sudden death, so there is a break between the receptions up to 6 hours. The reduction in the reception interval is possible with exceptional situations and should be reasonable.

Salbutamol during pregnancy

None of the tocologists were created specifically for preventing premature birth, so all drugs affecting the contractile activity of the uterus have polyorgans (characterized by a violation of work 2 and more child organism systems) side effects. When they are used, there is a transplacental transfer of active substances.

Among other cocologists β2 agonists are relatively safe for the child, but they also penetrate the placenta and can cause tachycardia of the fetus, provoke hyperinsulamia (elevated insulin level), hypoglycemia (low glucose level). Apply a broncholic during pregnancy follows after evaluating the intended benefits and possible risks.

Medicinal interaction

When appointing broncholics, it should be taken into account its influence on the pharmacology of other drugs used in order to therapy of concomitant diseases. Simultaneous with other medicines, the use of salbutamola causes the following effects:

• enhances the effect of stimulants of the central nervous system (Fenamine, Cytion, Strychnine);
• when interacting with xanthines (euphilline, theophylline) increases the likelihood of tachyarhythmia;
• the simultaneous reception with the means of inhalation anesthesia (Aerran, Foranom, Gatalon) and anti-Parkinsonic means (levodop, cognitive, nakom) can lead to severe ventricular arrhythmia;
• joint reception with non-selective β-adrenoblockers (propranolol, Levobunolol, Satolol) weakens the bronchodilitic effect;
• simultaneous use with m-cholinoreceptor blockers (pyrenspine, tritteramine) can contribute to an increase in intraocular pressure;
• diuretics (mercazal, diipeur) glucocorticosteroids (prednisone, hydrocortisone, betamethasone) should not be taken together with salbutola at low blood potassium content (hypokalemia);
• a joint reception with monoaminoxidase inhibitors (Moklobmeid, Selegyina) is not contraindicated.

Side effects

Allergic reactions in the form of urticaria, angioedema edema, paradoxical bronchospasm against the background of the use of salbutamola are rarely fixed. When prescribing the drug during pregnancy, it should be remembered that unwanted effects can be observed simultaneously with the mother and fetus. Often the bronchology causes:

• extrasystole (view of arrhythmia), tachycardia;
• dizziness, headache;
• nervous tension, insomnia;
• panic state, memory violation, aggressiveness;
• tremor, muscle cramps;
• sweating;
• vomiting, nausea;
• hypokalemia;
• arterial hypotension - decrease in blood pressure;
• delay urine.

Overdose

Symptoms of poisoning salbutol are tachycardia (up to 200 strikes per minute), arrhythmia, fatigue, dry mouth, dizziness. In case of overdose, blood pressure is reduced or increased, excitability, insomnia, hallucinations, muscle cramps, tremor, acidosis (violation of acid-alkaline balance with an excess acid), hypoxemia (reduced blood oxygen). In the presence of hypoxia (oxygen starvation), hypoglycemia is replaced by hyperglycemia. With signs of poisoning, symptomatic treatment is carried out.

Contraindications

Take the drug with increased sensitivity to its components should not be. He is contraindicated as a bronchology during pregnancy and lactation, children under 2 years old in the form of tablets, up to 4 years old - powder for inhalations. As a tocoliticism, it is impossible to use the drug in infections of generic pathways, defects and the death of the fetus, premature detachment of placenta, toxicosis, abortion threat. Contraindications to the appointment of medicines are:

• stenosis of the mouth of aorta;
• blocking the lumen of the heartfriend;
• coronary artery disease;
• myocarditis - inflammation of the heart muscle;
• arterial hypertension;
• hyperthyroidism, thyrotoxicosis - improving the function, high levels of thyroid hormones;
• hypokalemia;
• glaucoma.

Terms for sale and storage

Salbutamol is included in the list of medicines, the storage of which is recommended in iron cabinets and safes with the inscription "potent". Store the drug should be away from fire and high temperature sources, at home - at a temperature mode not higher than 30 ° C, in a place inaccessible to children. Freeze and store a medicine under direct sunny rays is impossible - this helps to reduce its effectiveness. Pharmacies Broncholitik is released by recipe.

Analogs

There are bronchopholics that have a similar pharmacological action, created on the basis of both salbutamola phosphate and alternative actors. Some Salbutamola Analogs are presented below:

1. Ventoline (United Kingdom) is a bronchhalytic drug in the form of an aerosol for inhalation based on salbutamola phosphate used to relieve asthma attacks. The drug is contraindicated with diabetes mellitus, impaired kidney functions, during 1 trimester of pregnancy.
2. Clenbuterol (Moldova) is a powerful β2-adrenomimetic based on a syrup hydrochloride hydrochloride. It is shown for symptomatic therapy of bronchial asthma and chronic respiratory diseases. Appointed as an additional remedy against the background of corticosteroid therapy;
3. Berretk (Germany) is a solution for oral inhalation based on phenotherol hydrobromide, effective in symptomatic treatment and prevention of asthma attacks. A saline is used to dilute the solution, the spraying can be carried out using any available inhaler.
4. Foradil (Switzerland) - Powder Capsules for Fumarantol-based inhalations for use using an Aerolazer Inhaler, which is included in the package. Prescribed the drug in order to relieve and prevent bronchospasm. The capsule is placed in the inhaler, pierced, the airclaise mouthpiece is introduced into the oral cavity, the powder is sprayed with a deep breath of the patient.
5. Onbreza Brizhaler (Switzerland) - capsules with powder for inhalation in the gelatin shell, the active substance is a selective beta-2 adrenoreceptor agonist Maleat. The drug has a long, up to 24 hours, action in one-time reception. Relaxes a smooth muscles of bronchi, removes spasm.
6. Volmax (United Kingdom) - Tablets based on Salbutamol Sulfate conventional (2-3 hours) and prolonged (12-14 hours) actions. Used as a bronchological and tocolic agent. The drug is contraindicated during lactation, as a bronchology during pregnancy.
7. Aloprol (Yugoslavia) is a concentrate for preparing a solution for infusions based on salbutamol sulfate. It is introduced intravenously with severe bronchospasm for 2-5 minutes, if necessary, every 15 minutes. It can be used as a tocoleic, intravenously, drip, the speed of administration is 20-40 drops per minute.
8. Inhlorpir Respimat (Germany) is a solution for aliodaterol-based inhalation. Used to reduce the obstruction of the respiratory tract, improving the quality of life, tolerance of physical exertion in patients with chronic diseases of the lungs and bronchi.

Price salbutamola

In pharmacies of the Moscow region, the drug and its synonyms are widely represented in the form of an aerosol for inhalation of domestic and foreign manufacturers. The cost of Broncholitics fluctuates depending on the form of release, the country of production and surcharges of suppliers. When ordering medicines in Internet pharmacies, the cost of delivery should be taken into account.