Release form: Liquid medicinal forms. Injection.

General characteristics. Structure:

Pharmacological properties:

Indications for use:

Important! Get acquainted with treatment

Method of use and dose:

Features of application:

Side effects:

Interaction with other drugs:

Contraindications:

Overdose:

Storage conditions:

In the place protected from light at a temperature not higher than 25 ° C. Keep out of the reach of children. Shelf life is 2 years. Do not use the expiration date specified on the package.

Leave terms:

On prescription

Packaging:

The solution for injection of 10% in ampoules 2 ml or 5 ml per package No. 5, No. 10, No. 20.

Chloride carnitine contains an active ingredient chloride carnitine as well as water for injection as an additional component. A substance is obtained by synthetic.

Form release

The tool is produced in the form of a concentrate, which is used to prepare a solution for infusion. The liquid without color is packaged in ampoules of 5 ml. In the cell pack - 5 ampoules.

pharmachologic effect

Carnitine substance is a metabolic agent. It provides stimulation of metabolic processes, taking an active part in different levels of energy exchange. The substance contributes to the activation of lipid metabolism, stimulating regeneration processes increases, acts as antihypoxic, anabolic, antihyroid means.

This natural substance similar to the group V. lowers the basic exchange, slows down the processes of the decay of proteins and carbohydrate molecules. Carnitine in the body mobilizes fat from fatty depot.

Notes also neurotrophic influence, remedy restores the structure of the nervous tissue and limits the lesion zone. Under the action of carnitine there is a braking of apoptosis.

When applied in the body, the normalization of fat and protein metabolism is noted, an increased major exchange in patients is normalized. Since carnitine is a partial antagonist. Reduces products ketokislot , Restores the alkaline reserve, does not affect blood coagulation. Increases the level of tissue resistance to the action of toxic decay products. Demonstrates antihypoxic properties , ensures the stimulation of reparative processes.

Pharmacokinetics and pharmacodynamics

After the chloride carnitine is introduced into the patient intravenously, it is not determined in the blood after three hours. It has its rapid penetration into myocardium and in the liver. Through the kidneys from the body is excluded mainly in the form of acyl esters.

Indications for use

The tool may be assigned in the following cases:

• with acute violations of blood circulation of the brain (in different periods of ischemic , with a transient ischemic attack);
• with discirculatory ;
• with toxic and chronic brain lesions;
• when anorexia , hypotrophy ;
• when delayed growth in children.

Medicine can be appointed in comprehensive treatment diseases under which anabolic nonteroid drugs. There are evidence that chloride carnitine is effective in the treatment of focal sclerodermia .

Contraindications

It should not be prescribed this LAN if the patient has a high sensitivity to this drug. Not recommended for receiving for children under 18, since it has not been studied the use of this medication in children and adolescents.

Side effects

During treatment, some side effects may develop:

• People S. urema ;
• pain in the course of veins, provided that the introduction occurs quickly (more than 80 drops per minute).

If the solution is administered intravenously with people with a changed venous wall over a long period, an irritant effect of carnitine can be marked. It decreases if providing stronger drug breeding.

Instructions for the use of chloride carnitine (method and dosage)

Instructions for carnitine chloride provides that the drug is injected intravenously drip. Introduction should be slow - no more than 60 drops per minute.

Before entering the drug, 5-10 ml, the means must be dissolved in 200 ml of 0.9% sodium chloride solution.

People who are diagnosed with a sharp impaired blood circulation of the brain, in the first three days the application of 1 g of medication is shown once a day, then over the course of seven days it is necessary to use 0.5 g per day. It is recommended to conduct a re-course, applying 0.5 g of the tool once a day, within 3-5 days.

People with lesions of the brain, discirculatory encephalopathy, during the recovery period after a stroke, shows the introduction of 0.5-1 g of medication per day for 3-5 days. The doctor may appoint a repeated course after 12-14 days.

Overdose

There is no data on the overdose of drug chloride medication.

Interaction

With simultaneous reception with GKS, carnitine can accumulate in tissues (with the exception of the liver).

The carnitine action is enhanced by simultaneously receiving with anabolic agents.

Terms of sale

You can purchase a remedy without a recipe.

Storage conditions

Chloride carnitine needs to be stored at a temperature of not more than 25 degrees.

Shelf life

Storage period - 4 years. It is forbidden to apply after the expiration of this period.

special instructions

There is evidence that the chloride carnitine is used in bodybuilding. But information about its application is often contradictory, in official instruction Such testimony does not mean.

Under the supervision of the doctor can be used in children when hypotrophy , anorexia , relief delay .

Analogs

Analogues of this medicine are drugs, Karniton , Carney Place and etc.

Children

In some cases, it is advisable to apply the solution to children with hypotrophy , anorexia , insufficient weight and growth. It is possible to apply only under the control of the doctor and after it is destination.

For weight loss

The fat burning function of chloride carnitine is noted. This medicine is used to reduce fat deposits. People who seek to reduce body weight.

During pregnancy

Since specifically studies of the use of drugs during and with not carried out, this tool can be applied only after a thorough assessment possible risk and expected benefit.

transparent colorless or slightly yellowish solution.

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pharmachologic effect

Stimulates metabolic processes by participating in various units of energy exchange. It has an anabolic, antihypoxic and anti-ramp effect, activates the fat exchange, stimulates regeneration, increases appetite. Carnitine is a natural substance, the Vitamin Vitamins of the V. Vitamins is a cofactor of metabolic processes that ensure the maintenance of the activity of KOA. Reduces the main exchange, slows down the decay of protein and carbohydrate molecules. Promotes the penetration of mitochondrial membranes and splitting long chain fatty acids (palmitic et al.) With the formation of acetyl-coa, necessary to ensure the activity of pyruvaturboxylase in the process of gluconeogenesis, the formation of ketone bodies, the synthesis of choline and its esters, oxidative phosphorylation and the formation of ATP. Mobilizes fat (the presence of 3 labile methyl groups) from fat depot. Competently displaced glucose, includes a fat-acid metabolic shunt, whose activity is not limited to oxygen (in contrast to aerobic glycolysis), and in connection with the drug effectively under the conditions of acute hypoxia (including the brain) and other critical states. It has a neurotrophic effect, improves protein and fat metabolism, an increased primary exchange for thyrotoxicosis (being a partial thyroxine antagonist). Restores the alkaline blood reserve, does not affect the rolling system of blood, reduces the formation of ketok acids, increases the stability of tissues to the effect of toxic decay products, activates anaerobic glycoliz, has antihypoxic properties, stimulates and speeds up the reparative processes.

Pharmacokinetics

3 hours after intravenous administration, almost completely excreted from the blood. Easily penetrates the liver and myocardium, slower - in the muscles. It is removed by the kidneys mainly in the form of acyl esters.

Indications for use

Treatment of primary and secondary carnitine deficiency in adults.

Secondary carnitic insufficiency in adult patients who are conducted by hemodialysis.

Suspicion of secondary carnitine insufficiency in patients who are conducted by hemodialysis in the following cases:

· Strong and persistent spasms in muscles and / or hypotensive episodes during dialysis;

· Energy deficit, which leads to a significant negative impact on the quality of life;

· Schechenoy weakness and / or myopathy;

· Cardiopathy;

· Anemia that is not responding to erythropoietin treatment or requiring high doses of erythropoietin;

· Muscle loss.

Contraindications

Childhood up to 18 years old.

Increased sensitivity to the components of the drug.

Pregnancy and lactation period

During the preclinical research of teratogenic effects, the drug was not identified. With the use of the largest dose, 600 mg / kg of body weight, animals have noted a statistically minor increase in the frequency of the post-block death of the fetus in the early pregnancy. The significance of these results for a person is unknown.

Given the serious consequences of carnitine deficiency for a pregnant woman, the risk of treatment for the mother is considered large than the theoretical risk to the fetus in case of continuing treatment.

Carnitine is the usual component of breast milk.

Method of application and dose

Intravenously drip slowly (no more than 60 drops per minute!). Before administering every 100 mg of the drug (1 ml of 10% solution) is dissolved in 50 ml of sodium solution of chloride isotonic 0.9% or 5% glucose solution.

Application with congenital metabolic violation

During therapy, it is advisable to control the levels of carnitine and acyl-carnitine both in the blood plasma and in the urine.

The necessary dose depends on the specifics of the congenital impairment of metabolism and the severity of the disease manifestations.

Secondary carnitine deficit in patients who are conducted by hemodialysis

Before starting therapy, it is desirable to control the level of carnitine in the blood plasma. The secondary deficit of carnitine is diagnosed with the ratio of excilitation to free carnitine in the blood plasma more than 0.4 and / or when the concentration of free carnitine is less than 20 μmol / l.

Dose 2 g should be administered intravenously drip slowly at the end of each dialysis session. The overall reaction should be determined by monitoring the levels of acyl, and free carnitine in the blood plasma and the assessment of the patient's condition. Normalization of the content of carnitine in muscle tissue and cardiomyocytes occurs, approximately 3 months after reaching the normal concentration of the carnitine in the blood plasma. If the introduction of carnitine stop, its level, certainly, will begin to decline again. The need for a repeated saturable course of treatment is determined by quantifying carnitine in blood plasma at equal intervals and by monitoring the patient's condition.

Hemodialysis-supporting therapy

After the saturated course of the introduction of carnitine, a supportive dose is used - 1 g of carnitine per day orally. On Dialysis Day, the drug is used intravenously at a dose of 1 g immediately after the completion of the next session.

Children

The drug is contraindicated to children, since special research of the safety of D, L-carnitine in children was not conducted.

Side effect"Type \u003d" Checkbox "\u003e

Side effect

Different moderate gastrointestinal disorders were observed with long-term intake of oral carnitine, including fleeting nausea and vomiting, abdominal pain and diarrhea. Reducing the dose often reduces or eliminates gastrointestinal symptoms. It is necessary to carefully monitor portability during the first week of reception and after any increase in dose. Intravenous use of the drug, usually transferred well. With quick administration (80 drops / minute or more), it is possible to occur pain along the veins passing when the introduction rate is reduced.

Overdose

There were no messages about the toxicity of carnitine in overdose. Large doses of the drug can cause diarrhea. Carnitine is easily removed from blood plasma by dialysis.

Turn

Sports food is replete with various additives and mixtures. One of the most common is L-carnitine in ampoules, which is sometimes considered to be vitamin-like or fat burning substance. But it is not. In fact, a solution of L-carnitine does not burn fats, but ensures their transportation into muscles to convert into energy during loads, being an amino acid.

This tool is useful not only for athletes, because it has a number of properties favorable for the body:

1. Helps to lose weight. Reception of L-carnitine (only with physical activity) according to the results, we compare with injections for weight loss.
2. Useful for blood system. Due to the removal of toxins and unwanted elements from the body, the blood becomes cleaner.
3. Without side Effects. This is a natural natural substance that is in the body.
4. Protects muscles. Muscular fibers are less suffering and are restored faster at the reception of creatine.

It is known that this amino acid itself is produced in the human body, but not always enough of its concentration for a complete effect. Therefore, in order to improve the state of health and strengthen the effect of training, it is recommended to take L-carnitine in ampoules (or in another form) for medical purposes.

Carnitine description in ampoules

To understand the features of L-carnitine in ampoules, it is necessary to compare it with other forms of this substance that exists on sale. The main parameters are the rate of assimilation, the presence of additives and cost. Comparative data are shown in the table below.

Despite the fact that L-carnitine in ampoules has a relatively high cost, it is very convenient in use, because the necessary dosage is calculated in each ampoule. In addition, it is instantly absorbed, which makes the injecting the best form of use of this amino acid.

The amino acid is recommended for absolutely everyone who wishes to improve their overall condition of the body. Especially actively it can be used athletes to improve the results of workouts. In this substance also need babies, pregnant women, elderly.

L-carnitine in ampoules should be administered intravenously. According to the instructions, the contents of one ampoule should be dissolved in 200 ml of solution for injection and drip slowly, up to 60 drops per minute. Usually, the course passes 4-5 days, which in two weeks it is recommended to repeat.

With this method, the amino acid falls directly into the blood and is instantly absorbed. True, after 3 hours it is no longer left in the body.

It should not be assumed that L-carnitine in ampoules is an injection injection. To reset excess weight, in addition to injections, it is necessary to regularly engage in physical activity!

Rating manufacturers

What manufacturer l-carnitine to choose? This is actually a difficult question, because on the shelves there are a lot of different trademarks, and the Sportwiki site will help to choose from them, where the vote is arranged.

The remaining manufacturers scored no more than three percent of the votes. Interestingly, 11% voted for a random option. Choose only what is suitable for you!

L-carnitine is a natural amino acid produced by the body independently. Sometimes a person needs an increased dose, therefore injections and other forms of substance come to the rescue. It is also known that these are not injections for weight loss, but a special additive for better fat burning. L-carnitine can, and sometimes you need to eat even young children, not to mention athletes. No side effects and overdose in a healthy organism were found.

N. Despite the almost 100-year history of the study of Carnitine (it was opened by Russian scientists V.Gulevich and R. Krimberg in 1905), this, according to the definition of Frankel, the "natural substance of the growth of living organisms" continues to keep its biological secrets, including The mystery of the nucleation and the duration of life itself.

In Russia (USSR) domestic drug DL carnitine chloride was designed in NGOs "Vitamins", and since 1978 its industrial release was launched in the form of a 20% solution for intake. However, a deep clinical study of DL carnitine chloride began in 1986, after us, in the clinic of nerve diseases 2 Molm. N.I. Pirogov, under the leadership of Academician Ramna, Professor E.I. Guseva, in collaboration with NGO "Vitamins" (prof. V.M. Avakumov) was developed and tested in the clinic on volunteers injection form Chloride carnitine for intravenous application In the form of a 10% solution. Since 1993, a 10% chloride carnitine solution is allowed for intravenous administration of MC Pf.

Over the past years in the clinic of nerve diseases of the RGMU (former 2 molm) accumulated large clinical experience Applications of chloride carnitine in the treatment of patients with diseases nervous system. To better understand the mechanisms of therapeutic action of DL carnitine chloride and estimate its advantage over other carnitine preparations (in particular, L-carnitine), it is necessary to familiarize themselves with the role of carnitine in the exchange of substances of a developing body, because With many brain lesions, metabolism in the nervous tissue returns to the embryonic level and for its restoration it is necessary to re-pass all the intermediate stages in which the carnitine plays a leading role, and in the body of an adult, its reserves are very limited in the organ.

Penetrating into the female spermatozoa female egg, carnitine activates genetic mechanisms for the synthesis of own carnitine. An increase in the level of carnitine in the egg launches enzyme system of life support proprietary and the whole process of its growth. All the newly formed during the development of the fetal cells, including neurons, synthesize their own carnitine, which they produce during the entire period of their life in the required quantities depending on the degree of maturity, the functions performed, the singularity of the exchange in this tissue, its structural integrity.

One of the main functions of the carnitine is the vehicles of fatty acids (LCD) through the membranes of intracellular organelle, in which their oxidation occurs with the formation of energy and "building materials" necessary for the development of the nervous system and the growing organism. In poor oxygen and glucose medium where the fruit is developing, fatty acids are the main source of energy, because In contrast to glucose, they can oxide at low oxygen values \u200b\u200bin the blood, but require a large amount of carnitine. Therefore, the synthesis and the need of carnitine in the body of the fetus goes in increasing progression. In the early stages of development, the oxidation of the LCD occurs in the "ancient" organellah cells - oxisomas, peroxyomas and later in young - mitochondria.

Very important, the vital product of the oxidation of the LCD under hypoxia is the formation of the body and accumulation in the blood by the time of the birth of endogenous carbon dioxide. Thanks to this carbonity, the newborn makes the first and all subsequent breaths in their lives, because Without it, the flow of oxygen from the air into the human body is almost impossible. Together with the energy supply of the fetus carnitine is involved in the most important processes of formation and development of the head and spinal cord, vegetative nervous system . IN initial stage The development of carnitine is the only neurotransmitter (conduct nervous impulse) and, having structural similarity with acetylcholine, it itself performs its functions, laying the basics of neuromuscular reception, forming and "training" neurotrophic cholinergic (controlled acetylcholine) structure, as well as the parasympathetic department of the nervous system, responsible for growth processes, creation, accumulation, structural integrity and restoration of all tissues of the body.

In the first years of life, the value of the carnitine for the body remains very important. With his participation, the growth of the head and spinal cord continues, the interaction of all the departments of the nervous system responsible for the movement and muscle interaction are improved. The energy supply of the entire body and the brain is carried out due to two parallel processes in mitochondria: more ancient carnitine-dependent oxidation of fatty acids and the young, typing the oxygen-dependent oxidation of glucose - aerobic glycolysis.

After 5 years, many karnitin functions take on the gland of the internal secretion. Synthesis of carnitine begins to slow down, the vehicles of fatty acids in mitochondria decreases, and they are gradually completely displaced from the energy process. In an adult, the energy of the brain receives at the expense of powerful aerobic glycolysis. Synthesis of carnitine continues at a very low level, and it is fully used by the cell itself to maintain its structural integrity and nervous impulse.

Carnitine is synthesized in the cytoplasm of nerve cells, from where with the help of "concentration transport mechanisms" comes from nerve fibers into the zone of its metabolic or neurotransmitter responsibility. Especially much synthesized carnitine in those brain departments that carry a large functional load (hypothalamus, cerebellum, spinal cord, bark).

The special role of carnitine plays in a complex regulation circuit of movements. This is due to the fact that the first motor receptor transmits the nervous impulse from the motion centers, and the final, performing in neuromuscular synapse is cholinergic. According to the latest scientific data, Carnitine "facilitates a meeting" acetylcholine with these receptors, adjusting the passage of a particular nervous command: the carnitine d-isomer passes the "brake" pulses, and L-isomer - "activating". Consequently, without the participation of DL carnitine, the motor system cannot function normally.

Thus, any violation of the motor function, from paralysis to hyperkinesov, can be considered from the position of local neuronal carnitine failure. And the stronger the synthesis and transport of carnitine in the affected brain area, the rougher there will be motor disorders in the innervated muscle group. Timely replenishment of this deficiency with the help of DL carnitine chloride has a powerful therapeutic effect With many motor disorders. This allows us to approve the experience of 17-year-old applying chloride carnitine for the treatment of violations of the motor sphere more than 1000 patients (newborns, children and adults) various diseases nervous system.

So, childish cerebral paralysis (PPC) is characterized by rude disorders of movements. It develops due to damage generic injury Perivnricular brain area. In the area of \u200b\u200bdamage, the synthesis of carnitine is disturbed, the conditions of the nerve impulse are worse through this zone to other engine centers, which ultimately manifests itself in the form of violent movements (hypercines) and other motor disorders. Regular reception of chloride carnitine (inside) , in the form of monthly short courses for 6-8 months in the first years of the child's life (especially important up to 5 years), almost completely eliminate the symptoms of cerebral palsy .

With peripheral paralims, the karnitin deficiency arises due to the violation of its transport in nerve, and with the damage of motor cells of the spinal cord - and by reducing its synthesis. Treatment of such patients, in particular, with paralysis of the facial nerve carnitine chloride (intravenous), gives a positive result even with diseases of 7-10 daily presses.

Neuronal deficiency of carnitine takes place in chronic progressive diseases of the nervous system (multiple sclerosis, lateral amiatrophic sclerosis, parkinsonism, brain atrophy, etc.). Chloride carnitine these patients received for a number of years (up to 7 years), short courses (from 4 to 6 per year). In the treatment of patients with scarmed sclerosis They had a significant improvement in movements, a decrease in muscle spasticity, tremor, gait rods. The exacerbations of the disease and their severity became less likely (especially with the duration of the disease under 5). The quality of life of patients has increased, some of them gave birth to a child without negative health effects.

In patients with lateral amiatrophic sclerosis in the treatment of carnitine chloride, an improvement has been observed for 3 years general status, Improving muscle strength, disappeared by eating, it became clear, the respiratory disappeared in a dream disappeared. Encouraging results were also obtained in the treatment of patients with Parkinsonism, especially with the duration of the disease under 3 years. Against the background of receiving the carnitine chloride, the tremor disappeared and the muscle rigidity decreased. Most patients were able to refuse to receive anti-Parkinsonic drugs, remaining at short supporting courses of carnitine.

Acute neuronal carnitic insufficiency develops in the brain in stroke and traumatic damage. Emergency intensive therapy of carnitine chloride in the first three days of the disease allows not only to protect the brain from the damaging effect of ischemia and hypoxia, activate backup links of energy (fatty acid) metabolism and "process of restoration of the structural integrity of the nervous tissue, but also to slow down the reactions and mechanisms of genetically programmed death of nerve cells (apoptosis). That the multilateral therapeutic effect of chloride carnitine allows you to minimize the violation of neurological functions in stroke and other heavy lesions of the nervous system, to return patients to capacity, social usefulness and high quality of life.

DL carnitine chloride has undoubted advantages over other carnitine preparations, in particular, L-carnitine. So, chloride carnitine is not removed from the body during the day (like L-carnitine), and quickly accumulates, embedded in metabolic processes and continues to operate after the drug is abolished for another more than 10 days. Chloride carnitine actually acts soothing, "extinguishes" epileptic activity, normalizes blood pressure and cardiac activity in vascular patients. L-carnitine in these patients acts excitingly up to epic syndrome, causes tachycardia, violation heart Rhythm, climb arterial pressure. Chloride carnitine has a powerful "awakening" action in patients with cerebral komoy, quickly restores the activity of the stem respiratory center. He removes dependence on alcohol and drugs, quickly restores functional state the organism in fatigue syndrome is good to a tool The prevention of stroke (for 17 years of observation in any patient treated in the acute period of carnitine disease, there was no repeated acute violation of the cerebral circulation).

Thus, chloride carnitine is a reliable means of metabolic therapy of sharp and chronic diseases nervous system. In its effectiveness, he is currently superior to other cerebral metabolics.