Alprazolam instructions for use. Preparation "Alprazolam": reviews and use. Trade names of drugs with the active substance Alprazolam

23.07.2020 Preparations

Alprazolam is an anxiolytic drug that has some antidepressive, anticonvulsant and hypnotic effect.

The medicine helps to increase the braking effect of gamma-amine-oil acid to the central nervous system, and also contributes to an increase in the sensitivity of the GAB-receptor to this mediator.

In this article, we will consider for what doctors are prescribed Alprazolam, including instructions for use, analogues and prices for this drug in pharmacies. Real meetings of people who have already used Alprazolam can be read in the comments.

Composition and form of release

The drug is produced in the form of tablets, 10 pieces per blister (5 blisters in a cardboard box) and 50 pieces in polymeric banks (1 bank in cardboard package).

Each tablet is designed for oral application and contains 0.25, 0.5, 1 or 2 mg of the active substance Alprazolam.

Pharmacological action: It has antidepressive, sleeping pills, tranquilizing, mioryexing central, anti-epileptic effect.

Indications for use

Alprazolam is used for patient therapy with neurotic and neurosis-like disorders that are accompanied by a sense of anxiety and anxiety. Alprazolam can be appointed patients with reactive depressive states, including evolving against the background of somatic diseases.

The drug can be used to treat patients with panic disorders, insomnia and abstinence syndrome (including alcoholic and narcotic abstinence syndrome).

pharmachologic effect

Alprazolam is a tranquilizer that has an anxiolytic, sleeping pills, sedative, anticonvulsant and central muscle plating effect.

It slows down polysinactic spinal reflexes, limbic system, thalamus and hypothalamus. Under its influence, concern and emotional tension decrease, there is a weakening of the feeling of anxiety and fear.

According to reviews, Alprazolam causes muscle relaxation and has a moderate sleeping pills. With its reception, patients fall asleep faster, the duration of sleep increases, and the number of night awakening decreases.

Instructions for use

According to the application instructions, it is recommended to use the minimum effective doses of Alprazolam. The dose is corrected in the process of treatment, depending on the effect achieved and tolerance. If you need to increase the dose, it should be increased gradually, first in the evening and then in the daytime reception.

The initial dose is 250-500 mcg 3 times / day, if necessary, it is possible to gradually increase to 4.5 mg / day.
For older or weakened patients, the initial dose is 250 μg 2-3 times / day, supporting doses - 500-750 μg / day, if necessary, taking into account portability, the dose can be increased.

The discontinuation of alprazolemic reception is produced gradually, since with a sharp cancellation develops the abolition syndrome, manifested in a sharp return of symptoms, to eliminate which, in fact, the drug was taken. Moreover, with the syndrome, the abolition of symptomatics, as a rule, becomes more pronounced than before the veryrapy of alprazolam.

Alprazolam cancellation is canceled for 2 to 6 weeks (depending on the magnitude of the therapeutic dose), reducing the daily dosage by 0.25 - 0.5 mg every three days. And first reduce the morning dose, then daylight, and only after that evening.

Contraindications

Contraindication to the purpose of Alprazolam are cases:

Breathing disorders, including in acute form;
Lack of liver and kidney function;
Pregnancy breast-feeding;
Age restrictions - under 18 years;
The presence of glaucoma (at the time of attacks, or predisposition);
Poisoning alcohol, drugs, drugs;
Individual sensitivity and / or intolerance drug.
Alprazolam patients with alcoholism should not be prescribed (in the period of therapy, Alprazolam is prohibited by consumption alcoholic beverages and drugs containing ethyl alcohol).

During the reception of the drug, Alprazolam should not be engaged in activities, which requires increased concentration and velocity of psychomotor reactions.

Side effects

According to the reviews about Alprazolam, in the first phases of treatment, the patient may develop a sense of drowsiness, fatigue, dizziness and ataxia. It may also reduce the ability to concentrate attention, develop disorientation, instability of the gait, slowing down motor and mental reactions.

In some cases, the use of Alprazolam may cause the following side effects:

Allergic reactions: skin rash and itching;
From the CNS side - a sense of fatigue, drowsiness, dizziness, ataxia, the instability of the gait, a decrease in the concentration of attention, depression, reduction of memory, the depression of mood, miastic, weakness; In some cases - paradoxical reactions (irritability, suicidal inclinations, hallucinations, psychomotor excitation, confusion, outbreaks of aggression, muscular spasm);
From the urinary system: incontinence or urine delay, violation of kidney functions;
From the side of the cardiovascular system: reduction arterial pressure and tachycardia;
From side digestive system - heartburn, dry mouth, nausea, vomiting, diarrhea or constipation, decreased appetite, jaundice, violation of the liver function;
From the system of blood formation: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenia;
From side endocrine system - disturbance of libido, change in body weight, the failure of the menstrual cycle;
In the treatment, it should be borne in mind that long use Alprazolam in high doses can be addictive.

Overdose Alprazolam is manifested in drowsiness, confusion of consciousness, coordination disorders, reducing reflexes, coma. In some cases, the deliberate overdose of this drug can lead to a fatal outcome.

The fatal overdose was registered in patients who took medicine in combination with benzodiazepines, alcohol (blood alcohol level was significantly lower than the degree of alcoholization, leading to death).

Analogs of Alprazolam

Structural analogues for the acting substance:

Alzoles;
Alproks;
Solomax;
Cassadan 0.25;
Cassadan 0.5;
Xanaks;
Ksanaks Retard;
Nourill 0.25;
Neurol 1.0;
Frontin;
Helex.

ATTENTION: The use of analogs should be coordinated with the doctor.

Price

The average price of Alprazolam, pills in pharmacies (Moscow) 380 rubles for 30 pieces.

Terms of sale

The medicine is released in pharmacies without a doctor's prescription.

Diana
I suffered in almost 15 years. They mocked at me several times a day. I wanted to sigane even from the balcony. Lyed several times in neurology. They gave phenozepam and anaprilin. While she took tablets everything was OK. They discharged and appointed Anaprilin and Alproroles overnight. But I was afraid of addiction and again began to go crazy. Attended psychotherapists and many all sorts of charlatans. Results zero. And then I got to the sensible neurologist and she advised me to drink Alproroles and Anaprilin without waiting for an attack with small doses the quarter of Alprosalama and half anaprilina 10 mg and I began to come to life. Well, of course, sometimes sometimes after stress all sorts, but not every day. The fool was that he was afraid to take them right away, maybe it would be already a full-fledged person, and so everything was launched for 15 years.
Igor
Alprazolam Normal trunk for a short time of treatment took 4 years decided to leave two days on the third head to the doctor for the recipe. I thought the end to me would come such a powerful cancellation syndrome. It is sick of food does not climb, comes in the throat thumps, go to bed, went to bed as if scared. Crying hunting in the head of the fog of Bedni all sorts of wagon climb. Everything annoys.
The doctor said to drink Tibe their whole life, and I bought 26 duties in the pharmacy 2standard (2 packs) drank a tablet and was born again. But the second year we have problems with them in the pharmacy, but bring 10 standards and as a crows, I will bring everything from They littered the scandal on the nervous scandal. I took it from 1.5 months from them 14 tablets. Duties in the pharmacy ask whether to go for the recipe, it's not usually, in no, but I go to Moscow. The tablet on the tablet on the watch is enough and went. Four days drank one, poor well-being but not such as not at all.
Then he decided again the risk lasted the day, it was sick as if it was poisoned. On the night of all the way the floor of the tablet drank. I fell out normally. If not to consider the fact that we sleep at five o'clock per day. On the next day, again Tirpel, hard seizers saved the Internet, I work in the protection therefore from the Internet did not go helps to forget for a while. The second also stretched out for the night did not drink the duties to sleep. Bad but sleeved. Extraked feelings. The day of the day is also the Internet. But nausea was less. In addition, Kvas Ochakovsky 1.2Gradus alcohol minimizes on 5 or 6 day of the cancellation syndrome.
After 8 days, it felt already the norms with non-market parishes. After 15 began to forget about them .. today. A month as I do not drink them. Dome stayed still pills I am afraid of them like fire. So many reviews read about them and more than half write what they themselves did not experience. I really wish for those who throw them tirpeats. Very very hard, but the cancellation syndrome will be told. 15 days the biggest.

In this article we will deal with how much "Alprazolam" acts.

The drug is quickly absorbed into blood and quickly facilitates the symptoms, so it is suitable as emergency help In the stressful situation - after 15-20 minutes. The maximum concentration of the drug in the blood is achieved after 1 - 2 hours after the reception. Acts 2-3 hours.

It is a drug belonging to the category of tranquilizers. The drug is produced in tablet format. This medicine is included in the list of psychotropic medicines and is subject to quantitative accounting.

Reviews about Alprazolam are available in large quantities.

Composition of tablets

This tool is released only in one form - they are packed in a jar. Also they are packaged in blisters for ten or fifty pieces. "Alprazolam" refer to the group of antitrusive tranquilizers. The medicine is extremely rarely discharged for long-term treatment, as there is a danger of addiction.

The active component of these tablets is the same substance Alprazolam. Potato starch is served by the auxiliary ingredients along with the lactose monohydrate and low molecular weight.

Exposure mechanism

Tablets "Alprazolam" are prescribed short courses in order to quickly remove the nervous disorder. The antidepressant has a minelaxing and anxiolytic activity, and, in addition, has anticonvulsant and sleeping pills. This agent is taken to remove worry and unreasonable anxiety.

Alprazolam preparation allows you to increase the duration and quality of sleep, reducing the fallback time and awakening. The presented tablets remove the brain excitability, dull the organism reflexes. The anticonvulsant effect involves removing the tension in the muscles and eliminate spasms. This leads to relaxation of the entire body, and, in addition, to emotional calmness.

Pharmacological properties of the drug

The drug performs high-precision benzodiazepine, reinforcing the braking effect of amine oil acid in the nervous system. The mechanism of the sleeping pill is as follows: during entering the intestine, the current component is rapidly absorbed in the body. The maximum concentration of this substance is observed two hours after the reception. In the liver, the current component is metabolized, and the resulting metabolites from the body are derived naturally with urine.

Indications for use

Tablets "Alprazolam" prescribe a doctor when diagnosing the following pathologies:

Having a man of neurosis, anxiety, irritability, anxiety disorders, states of excitement and emotional voltage. At the same time, patients have a worsening of sleep quality, along with nightmares, insomnia and frequent wakes in the middle of the night.
For somatic diseasesaccompanied by increased sweating, but, moreover, rapid heartbeat, bulimia, impotence or anorexia.
A person's stay in an alarm-depressive state leading to a decrease in mood and loss of interest in everything that happens around.
The drug is often prescribed in closetness or, on the contrary, excitation, against the background of suicide actions and endogenous depression. The readings "Alprazolam" must be strictly observed.
If there are neuroses, accompanied by the loss of appetite, and at the same time change in weight.
The presence of a depression flowing against the background of the disease, for example, due to oncology or infarction fear.
The drug is prescribed in the treatment of alcoholism or drug addiction.
The presence of phobias in various nature, including fear of open space, and the like.
The presence of tremor I. panic attacks.

Mode of application

The number of tablets for treatment depends on the dosage, age, the state of the patient and the sensitivity of the body to the components of the drug. Tablets, according to the instructions, are taken inward three times a day, regardless of food. The capsule is not chewed, but swallow in general by drinking with a large number of non-carbonated water. In order to mine the medicine, you will need not less than half of the glass of water.

The daily dosage of Alprazolam is not accepted at once, it is divided into three receptions. By the way, most part is recommended to be taken before bedtime, as it will contribute to the impact effect on the body. For instance, daily dose Tablets is 2 milligrams: in this case, the patient takes 0.5 milligram in the morning and at lunch, and immediately before bedtime, the dosing is 1 milligram.

The maximum daily dose should not exceed 10 milligrams. For older patients after sixty-five years maximum norm There are 1.5 milligrams per day. It is impossible to begin treatment without the designated dosing. Therapy should be started with a minimum dose from 0.25 milligram per day and gradually increase. Thus, for three weeks it is brought to the norm. Depending on the existing diagnosis, the following amount of the current component is assigned to the patient:

If there is anxiety, it is necessary to take 1.5 milligrams three times.
As part of the treatment of depression, 3 milligrams three times are taken.
If there are phobias or panic attacks, the dosage is 3 milligrams three times.

The course of reception "Alprazolam" is long or, on the contrary, short:

Long-term treatment with Alprazolam is prescribed rarely due to the set side effectswhich can cause this drug. Such treatment is appointed in chronic depression and a sense of anxiety.
A short course of therapy is carried out when it is necessary to stop sharp and at the same time a sudden fear attack, and then when you need to remove a nervous state. A short medical course lasts, as a rule, no more than seven days. In this case, the dosing is 0.5 milligram three times a day.

"Alprazolam" and addictive

Against the background of long-term use in high dosages, patients are very likely to add addiction along with the formation drug addiction. In particular, this happens in patients prone to medication abuse.

Reviews about "Alprazolam" confirm.

Termination of medication

A feature of these tablets is the cessation of therapy with long reception courses. It is necessary to do this gradually, otherwise the patient cannot avoid the next emergence of the same symptoms, for which the drug was prescribed to the relief.

The duration of the abolition of Alprazolam is, as a rule, from two to four weeks, which directly depends on the dosage. To do this, it takes every three days to reduce the dose by 0.5 milligrams. In the event that a decrease in dosing by 0.5 milligrams returns the previous signs of alarm, it is required to carry out a softer cancellation.

special instructions

As part of the appointment of this medicine, the doctor should make sure that the patient did not accept any other tranquilizers and is not sick of alcoholism. The effectiveness of therapy with the help of Tablets "Alprazolam" will be significantly lower in people suffering from alcoholism or drug addiction and different kinds Antidepressants.

They should not be taken in combination with other sedative medicines causing drowsiness. A long-term course of therapy with pills may cause a strong dependence on the "Alprazolam" in a patient, from which it will be difficult to get rid of. In this regard, it is forbidden to increase or lower the dose without consulting a doctor.

In the event that a dose is reduced quickly, you can feel the cancellation syndrome, which will be expressed in the form of vomiting, nausea, sweating, insomnia, feelings of anxiety, and the like. When, during treatment, the patient begins to complain about hallucinations, and, in addition, to convulsions, the emergence of aggressiveness and thoughts about suicide, it is necessary to contact the doctor.

"Alprazolam" during pregnancy

Take this tranquilizer during pregnancy is impossible. The active substance that is contained in this drug, at the beginning of pregnancy can cause violations of the development and growth of the fetus. In the last weeks of pregnancy, funds rarely, but gives a violation of development nervous system Future child.

In the event that the woman took the tablets of this drug immediately before childbirth, it can lead to a decrease in pressure and temperature, and, in addition, to a respiratory impairment and weak sucking reflexes in a newborn.

The acting component of the drug is able to penetrate the milk, so during feeding the reception of Alprazolam is prohibited. If the reception of these young mother tablets is still needed, she should translate his child to artificial feeding.

Medicinal interaction "Alprazolam"

Receiving tablets Against the background of simultaneous treatment with other drug drugs entails the following consequences:

In the case of simultaneous treatment with other psychotropic, and at the same time, anticipant and non-drugs in the form of drugs or sleeping pills may be the oppression of the nervous system.
Overdose of Alprazolam tablets, along with an increase in its effectiveness in the case of admission oral contraceptives, Ketoconazole, Paroksetina and Fluvoxamin.
"Alprazolam" increases the toxicity of "Zidovudine".
"Alprazolam" oppresses breathing while taking a "clozapine".

Side effects

According to the reviews about Alprazolam, tablets can sometimes give the following side effects:

The emergence of feelings of fatigue, drowsiness, slowing down reaction, depression, dizziness, disorientation, tremor or insomnia.
The presence of dryness in the mouth, nausea, constipation, diarrhea, disorders of the functions of the liver and kidney. The appearance of jaundice is not excluded.
Answering anemia, chills, increased temperature, pain in the throat, thrombocytopenia and neutropenia.
The development of enuresis, urine delay. It is also possible to reduce libido and dysmenorrhea.
Reduced pressure and tachycardia.
Development allergic reactions.
Weight change along with impaired vision. Side Effects "Alprazolam" are described in detail in the instructions.

Overdose medicinal drug

Treatment with psychotropic drugs should be implemented strictly according to the instructions. In the event of an increase in the dose of the drug from 500 milligrams per day in patients, an overdose is observed. Signs of an overdose of "Alprazolam" easy to recognize the following symptoms:

The emergence of clouding consciousness along with a decrease in reflexes.
The appearance of the man of drowsiness, shortness of breath and bradycardia.
Development of tremor and pressure reduction.

So, if you take as a sleeping bag "Alprazolam", you need to be careful.

Contraindications for use

The medicine has a large number of all sorts of contraindications. These tablets are prohibited in the following diseases and states:

On coma's background.
When Miasthenia and the Clothing Glaucoma.
In the presence of severe depression.
Against the background of poisoning with alcohol drinks.
The presence of diseases respiratory tract.
Patients age under eighteen years.
The presence of an allergic reaction to the drug.

Analogs of "Alprazolam"

These tablets can always be replaced with some other option with the same composition and sleeping pills. Among the analogues "Alprazolam" are very popular with drugs in the form of "Alzolam", "Zolomaksa", "Nordom" and "Heleks". Selected by the doctor.

Interaction with alcohol

Combining "Alprazolam" and alcohol is strictly prohibited, since this drug enhances the impact on the body of alcoholic beverages. In the event that a person will connect alcohol during treatment with this drug, this can lead to a sharp drops of blood pressure. In this case, in some cases, a stroke was observed.

Some people against the background of the simultaneous use of this drug with alcohol reported the appearance of chills. In addition, this combination can lead to vomiting or dizziness. With the simultaneous admission of alcohol with this drug, the blood clotting is disturbed, which leads to hemorrhages and bleeding. Improper treatment can lead to the oppression of the nervous system.

Alprazolam is drug Treatmentrelated to the anxiolytic group of the same name active substance.

Anxiolitics are. According to its chemical structures, this drug refers to .

Auxiliary substances included in the medication, depending on the content of the active substance in one tablet (0.25 / 1 mg):

lactose monohydrate (milk sugar) - 91.95 / 137.4 mg;
potato starch - 5 / 7.5 mg;
povidone (PVP low molecular weight medical), Plazdon K17 - 1.8 / 2.6 mg;
magnesium stearate - 1 / 1.5 mg.

Pharmacological properties

Thanks to the use of this medication The impact of an inhibitory nature increases. This acid is a mediator that performs pre- and postsynaptic braking during the transfer process nerve impulseswhich occur in the field of CNS.

Alprazolam carries out an anxiolytic effect, which is expressed in a significant reduction and decrease in the intensity of fear symptoms and.

Anxolytic activity arising from the reception of the drug is combined with moderate. This is expressed in a significant reduction in time for falling asleep, increasing sleep time and a significant decrease in the number of awakening at night. The mechanism itself, which arises sleeping action, It occurs due to a process that oppresses the cells of the reticular formation.

The use of Alprazolam does not affect the stability of the operation and operation of the respiratory organs, as well as the cardiovascular system.

Pharmacokinetics: suction, distribution, elimination

During oral administration, the greatest concentration of the drug in the blood plasma is observed several hours later. During single methods of the drug with a dosage not exceeding a mark of 0.5 mg, the greatest concentration is about 7.1 mg / ml.

It should be noted that there is a pronounced dependence of the linear type, which manifests itself with a dosage intake of alprazolam and its subsequent plasma concentration. During oral administration, the amount of the absorbed dose of the active substance reaches about 80%. In addition, this drug can penetrate the placenta, BGB.

It is possible to achieve a stable concentration of alprazolem in plasma only after several days (no more than three) of its continuous reception. Metabolization is the splitting of the means directly in the liver itself, and its further removal from the body occurs through the kidneys. The duration of time for the semi-anniversary of the drug from the body is not more than 16 hours.

The accumulative effect even with long-term use is minimal. After the discontinuation of medication, it is in rapid deadlines from the patient's body.

Objectives of application in what cases is effective

Alprazolam is used for long-term treatment of patients who have frequent. In addition, this medication is applied during the treatment of various kinds of disorders, which, as a rule, manifest increased level . Effective in composition complex therapy , .

Used to relieve suddenly emerging feelings, strong fears and feelings of anxiety.

It is worth noting that this drug is often used to treat patients with short courses. This is due to the fact that today there are many more promising in terms of safety and tolerance of tranquilizers - anxiolytic.

Alprazolam is applied small on the duration of the courses, but gives a quick effect in terms of the relief of the alarm, panic attacks and fears.

Alprazolam is effective:

for the treatment of disorders and, which are accompanied by the emergence of a sense of an inexplicable anxiety, permanent fear and other symptoms, which is closely related to the depressive state;
during treatment;
during the appearance of insomnia;
with sharp attacks of agoraphobia, which manifests themselves to be in the open space;
when appear;
for treatment;
when;
to relieve the symptoms of classic.

Contraindications for reception

Alprazolam is contraindicated for use by patients who are unnecessarily sensitive to benzodiazepines. In addition, this drug is contraindicated for the treatment of patients in coma or shock. It is not used for the treatment of people under the influence of alcohol or in acute narcotic poisoning.

It is not recommended to be used in the occurrence of lung diseases, with pronounced disorders that are related to the functioning of such bodies as a kidney or the liver, as well as pregnant women. It is not recommended to apply to the treatment of people in the severe form of depression during which suicide attempts were present.

clotted glaucoma;
respiratory failure;
when a variety of allergic reactions appear after taking medication.

With elevated caution, the means is prescribed to patients who are in a state and those that have a dependence on other drugs of similar action.

Only in extreme cases is prescribed for the treatment of patients suffering organic diseases in the brain area, the elderly.

The safety of the use of children and adolescents is not confirmed.

Dosage and reception mode: instruction

Alprazolam is accepted in the form of pills orally no more than two or three times in 24 hours. It is possible to take the drug regardless of the time and frequency of food intake. During the reception of the tablet, it must be swallowed without fonding and without grinding. Then save the amount of water.

Dosage is selected individually. At the same time, it is necessary to take into account such indicators as the age of the patient and its sensitivity to exposure active component. It is worth noting that for the elderly, the age of which exceeds 65 years, as well as for people who used to use psychotropic drugs before, a small dosage of Alprazolam is needed.

If during the course of therapy in the patient begins to develop strong drowsiness or the coordination of movements is disturbed, then the dose must be done less. When it should be carefully monitored for the patient's condition and well-being.

The daily dose is divided into several techniques (usually for two or three). The biggest dose must be taken in the evening, immediately before bedtime. This is due to the fact that the medication contributes to rapid falling asleep and evening reception minimizes drowsiness during wakefulness.

Reception of drugs must be started with minimal doses, which range from 0.25 to 0.5 mg in 24 hours. Next, the dose must be gradually increased to the desired level. An increase in doses should be carried out gradually, within one or two weeks.

The optimal therapeutic dosage to obtain a positive result differs. It depends, first of all, from the state in which the patient is located. The dosage varies and amounts to:

during the appearance anxiety dose from 0.25 mg to 0.5 mg, not more than 1 time in 24 hours;
for depression The daily rate of use is 0.5 mg, 3 times in 24 hours;
during panic attacks Dose from 0.5 mg and up to 1 mg, is accepted no more than 1 time per day.

The maximum allowed permissible daily volume should not exceed ten milligrams. The course of treatment can be both long and short.

The duration of the short course of treatment is from one to three days. A period of long-term treatment, using Alprazolam, from 3 to 8 months.

Side reactions and overdose cases

During the course of treatment, the occurrence of side effects may occur. In most cases, they arise on initial stage Treatment and then disappear in the process of receiving the drug or when adjusting the received dose.

To pronounced side effects include the appearance of a feeling of fatigue, drowsiness ,. Also possible appearance and dizziness. In addition, during the reception, the appearance of side effects during the operation of such systems is possible:

Digestive systems. In most cases, dryness in the mouth, vomiting, nausea, heartburn, constipation, or on the contrary, diarrhea is possible.
GOOD SYSTEM. Violation of the normal functioning of the kidneys, a decrease or on the contrary, an increase in libido, urinary incontinence or its delay.

The occurrence of allergic reactions in the form of itching or rash on the skin is possible. Diplopia is also possible and weight loss.

When taking too large doses of the drug, the number of which is 500-600 mg in 24 hours or more, overdose is possible. In the event of an overdose, the following symptoms appear:

drowsiness;
dyspnea;
tremor;
decrease in reflexes;
the emergence of bradycardia, reduced blood pressure or coma.

In case of overdose, the patient is washing the stomach. Then the reception of sorbents is assigned. The sorbents include enterosgel, activated carbon, polysorb.

Medical compatibility

The drug is able to provide enhanced effect on the body of other psychotropic type drugs. With a combination of alprazolam, together with antibiotics, which belong to the group of macrolides, as well as with hypnotics, there is an increase in the action of an oppressive nature on the CNS.

With a combination of alprazolam with oral type contraceptives, the process of removal from the patient's body is essential.

Special instructions and special patients

For the whole course of treatment, the patient should abandon alcohol. This limitation is due to the fact that the simultaneous use of the drug together with alcohol can cause low blood pressure.

If you can not refrain from the use of alcoholic beverages, disorders associated with blood coagulation may occur, vomit, chills. Also, the use of alcoholic beverages during drug intake can be caused by development, coma or infarction. Fully outcome is possible.

Pregnant women applying the means is allowed only in exceptional cases. The drug is toxic for developing fetus. It contributes to the appearance of a congenital character of the fetus. In addition, Alprazolam is able to cause the depression of the central nervous system from the unfortunate child.

Medication can not be used to treat children, especially in early age. This is because children's organism Very susceptible to the oppressive effect of the active substance on the CNS.

There is an opinion

About Alprazolam is predominantly positive reviews, not only from patients who used it when the course of treatment, but also doctors who used him in their appointments.

Read more clinical practice The use of Alprazolam B. B. Fursova and O. O. PSSEVEVE.

As patients noted, the medication copes with the relief of the feeling of anxiety and suddenly emerging panic attacks.

Unlike other tranquilizers, it practically does not cause drowsiness and weakness. Anxiolytic is suitable for those people who, during the course of treatment, go to work.

I took the drug more than one month. After its use, I have significantly improved the dream, I stopped waking up often at night (before that I woke up almost every 1.5-2 hours). I stopped tormented nightmares and permanent alarms. In addition, thanks to Alprazolam, I stopped to appear depressed and I began to enjoy life.

Luda

Very good tranquilizer. After his reception, I was ceased to visit panic attacks, which I started at a young age. I tried a lot of varied drugs, however, it was best for me precisely alprazolam. He eliminates unfortunate alarms and normalizes sleep. Although at the beginning Introduction I began to occur, side effects began to arise, but they were not very heavy and not in any comparison with the terrible state in which I was before the beginning of the course of treatment

Leonid

Purchase and storage

The drug is produced in the form of tablets, with a dosage of an active substance of 0.25 mg to 1 mg is implemented in the bank, it contains fifty tablets. There is also a form of release in contour packages of cell type. Each such package contains 10 tablets.

The shelf life is 4 years. After the expiration date, use is strictly prohibited.

Storage is carried out in a dark place, the temperature regime of which does not exceed 30 degrees Celsius.

Since Alprazolam refers to the preparations of a psychotropic group, his vacation is carried out by the prescription of the attending physician, the average price of 50 tablets is 1,200 rubles, 10-340 rubles.

The analogues of Alprazolam include: nosheps, Nordhurol, Hell, Cassadan, solutions for injections can be used as synonyms, such as.

Alprazolam is an anti-leaving agent (an anxiolytic) used to treat panic attacks and alarming disorders.

Composition, release form and analogs

The active active ingredient of the drug - Alprazolam.

Release form - tablets, packed in blisters of 10 pieces or in polymer cans of 50 pieces.

As part of one tablet Alprazolam 0.25 (1) contains 0.25 (1) mg of the active component and additional ingredients (starch, silicon dioxide, lactose, magnesium stearate, etc.).

The analogues of the drug include: Alzola, Zolomax, Alproks, Ksanaks, Cassadan, Nordhurol, Frontin and Hell.

Pharmacological effect Alprazolam

The drug is a tranquilizer from a group of benzodiazepine derivatives. It reduces the overall concern, causes muscle relaxation, and also has a moderate sleeping pills and an anticipant effect.

The pharmacological effect of the drug is based on the braking of the thalamus, hypothalamus, the limbic system and polysinactic spinal reflexes due to the binding of Alprazolam with benzodiazepine and gamingal receptors.

Under the influence of Alprazolam, according to the reviews, the flow rate is shortened and the duration of sleep increases, and the number of night awakens is reduced. The drug does not cause any changes from the respiratory and cardiovascular systems.

Indications for the use of Alprazolam

According to the instructions, Alprazolam is used as a weak antidepressant in integrated therapy of unexicotic disorders:

Mixed anxious depressive states;
Neuroses and alarming states with a sense of concern, anxiety, voltage, worsening sleep, irritability and somatic violations;
Neurotic reactive depressive states that are accompanied by a loss of interest in the surrounding, decline in mood, loss of sleep, anxiety, deterioration of appetite, changes in body weight and somatic violations;
Panic states, bouts of phobias and panic.

In addition, according to reviews, Alprazolam is effective in the treatment of neurotic depressions and anxious-depressive states developed against the background of various somatic diseases.

Contraindications

According to the instructions, Alprazolam are not prescribed to patients with the following diseases:

Miasti;
Respiratory failure;
Pronounced violations of the liver and kidney function;
Acute glaucoma attacks.

The drug is contraindicated to persons, in the history of which there are guidelines for hypersensitivity to the components of the drug or lactose intolerance.

Alprazolam is not used in acute alcohol poisoning, narcotic, sleeping pills or psychotropic drugs.

This medicinal product is not used in pediatric practice.

During the treatment period, Alprazolam is prohibited from the use of drugs and beverages containing ethyl alcohol, in addition, it should be limited to activities that require increased concentration of attention.

Method of use Alprazolam

The drug is intended for use inside. The dosage is established individually and depends on the course of the disease and tolerance.

The treatment of Alprazolam, according to the instructions, begin with a smallest effective dose of 0.25-0.5 mg three times a day. If necessary, and good tolerability can be gradually, every 3-4 days, increase the dose (first evening reception, then daily). The maximum daily dose is 3-4 mg.

Take the medicine preferably after eating, drinking water. Alprazolam's cancellation or dose reduction should be carried out gradually. A daily reduction of a dose by 0.5 mg or less every three days is allowed. In some cases, the abolition of Alprazolam should occur even slower. Course treatment with a drug is quite long and calculated months.

Anxiolytic is not recommended to use with other tranquilizers. With a sharp abolition of Alprazolam, the abolition syndrome may occur, which is manifested by different symptoms: from insomnia and weak dystrophy to heavy condition With tremor, convulsions, spasms in the abdomen and muscles and strong sweating.

Side effects

At the beginning of treatment, the drug is possible to develop drowsiness, increased fatigue, dizziness, disorders of the concentration of attention, drug dependence and deceleration of psychomotor reactions. The frequency of occurrence of such adverse Reactions Above the elderly patients.

Regardless of the term of treatment and age, Alprazolam can cause the following side effects:

From the sovereign authorities: a change in taste sensations and a decrease in visual acuity;
From the nervous system: insomnia, depression, headache, tremor limbs, confusion of consciousness, violation of coordination of movements and memory, rarely - hallucinations, outbreaks of aggression and violation of speech;
On the side of metabolism and digestive system: anorexia, a decrease in body weight, heartburn, nausea, dry mouth mucous membrane, jaundice, stool disorders;
Other - Miasthenia, Dystonia, Enuresis, urine delay, renal impairment, dysmenorrhea, Libido reduction.

Medicinal interaction Alprazolam

Persons with endogenous depression allowed the joint use of alprazolam and antidepressants.

With simultaneous use with sleeping pills, anticonvulsant, neuroleptic preparations, ethyl alcohol, narcotic analgesics and muscle relaxants marked a mutual increase in action.

The risk of developing adverse reactions increases with sharing Alprazolam with microsomal oxidation inhibitors. Reducing the efficacy of the drug is noted while using microsomal oxidation inductors. Anxiolytic increases imipramine concentration in blood plasma.

Storage conditions

Alprazolam is stored at a temperature of 15-30 ° CV protected from direct sunlight location. It is suitable for 5 years after the release date.

Instructions for use:

Alprazolam is a drug of antidepressive, sleeping pill and moderate anticonvulsant.

Release form and composition

The tool is produced in tablets with a dosage of 0.25 mg and 1 mg, 50 pieces per pack.

Indications for use

According to the instructions, Alprazolam is used at:

Disturbing states and neurosis, accompanied by a sense of danger or anxiety, worsening sleep, as well as somatic violations;
Neurotic reactive depressive states that are accompanied by a decrease in mood, insomnia, loss of interest in the surrounding and decrease in appetite;
Mixed anxious depressive states;
Panic disorders with symptoms of phobia and without them;
Anxious states and neurotic depressions developed against the background of somatic diseases.

Contraindications

In accordance with the instructions, Alprazolam is contraindicated to apply with:

Severe depression;
Clotted glaucoma;
Shock;
Acute alcohol poisoning, sleeping pills and psychotropic drugs, as well as opioid analgesics;
Chronic obstructive diseases of the respiratory tract with initial manifestations of respiratory failure;
Miasthenia;
Acute respiratory failure;
Increased sensitivity to benzodiazepines or other components of Alprazolam.

The use of Alprazolam during pregnancy is contraindicated due to the toxic effects rendered on the fruit.

The active ingredient of the drug is allocated with breast milk And it can negatively act on the newborn, so at the time of the drug intake, breastfeeding must be interrupted.

Alprazolam is not prescribed to persons under 18.

During the treatment period, alcohol is contraindicated.

In case of violations of the kidney or liver function, the drug should be used with high caution.

Method of application and dosage

According to the instructions, Alprazolam is recommended to be taken in minimal effective doses. The initial dosage ranges from 250 to 500 μg to three times a day. If necessary, it can be gradually increased to 4.5 mg per day. With a weakened organism, as well as in the elderly, the initial dose should not exceed 500-750 μg per day.

Side effects

Most often, side effects arise at the beginning of treatment and manifest as a sense of fatigue, drowsiness, dizziness, ataxia, a decrease in the ability to concentrate attention, the instability of the gait, disorientation, as well as the slowdown in mental and motor reactions.

In some cases, the use of Alprazolam may cause the following side effects:

CNS: Headache, Depression, Motion Coordination Disorders, Aggressive Flashes, Euphoria, Anxiety and Insomnia, Dystonic Extrapyramidal Reactions, Reducing Memory, Hallucinations, Concision Connection, Psychomotor Architis, Tremor, Mood Depression, Weakness, Miastration, Dysarthri , muscular spasm;
From the digestive system: a decrease in appetite, nausea, dry mouth or saliva, heartburn, constipation or diarrhea, vomiting, violation of liver functions, jaundice;
From the urinary system: incontinence or urine delay, violation of kidney functions;
From the cardiovascular system: reduced blood pressure and tachycardia;
From the system of blood formation: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenia;
Allergic reactions: skin rash and itching;
From the endocrine system: libido disorders, change in body weight and impairment of the menstrual cycle.

special instructions

In the treatment, it should be borne in mind that the long-term use of alprazolam in high doses can be addictive. Cancellation of the medicinal product must be carried out gradually. It is recommended to reduce the dose of 500 μg in the reception no more than three times a day. In some cases, a slower cancellation of the drug is required. A sharp cessation of alprazolema reception can lead to cancellation syndrome, which is manifested in the form of insomnia, reinforced sweating, cramps, tremor, as well as skeletal muscle spasms.

In the treatment of endogenous depression, the drug can be applied simultaneously with antidepressants.

Acceptance of alprazolam with psychotropic and anticonvulsants can enhance the negative effect of the drug to the central nervous system.

Care should be taken with the simultaneous use of drugs with histamine H2 receptor blockers, antibiotics from a group of macrolides, other tranquilizers and digoxin.