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The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!
Papaverine (Latin - Papaverine) is a widespread medicinal substance with antispasmodic, vasodilatory and hypotensive effects. By origin and chemical structure, Papaverin is alkaloid Opium poppy, that is, it turns out from the poppy straw, but is not a narcotic substance.Currently, in the countries of the former USSR, drugs, which include only Papaverin, are usually called "Papaverin" as an active ingredient. In some cases, letters or abbreviations, encrypting the name of the manufacturer of the manufacturer of the drug, for example, "Papaverin MS", "Papaverin Buffus", and others can be added to the word Papaverin, and others. However, in all cases, we are talking about the same drug produced by different plants. but containing the active component of Papaverin.
In addition, there are multicomponent drugs with other names containing simultaneously several active substances, among which there are papaverine. These are drugs such as Papazole, Andipal, TEOODIBAVERIN, etc. However, in this article we will consider exclusively monocomponent drugs containing only papaverin as an active substance and having the same name accordingly. To distinguish and not to confuse the active substance and the name of the drug, the first will write with a small letter, and the second - with a big one.
Monocomponent preparations containing only papaverine as an active substance are currently being produced under the following commercial names:
Accordingly, the composition of three dosage forms as an active substance contains papaverine hydrochloride in the following dosages:
Since the pharmacological effect of papaverine is multidirectional, it is attributed simultaneously to two groups of drugs, such as vasodilators (vasodilators) and spasmolytiki. Accordingly, papaverine is used as a spaspolytic to the treatment of functional disorders of the gastrointestinal tract, and as a vasodilator - in the therapy of erection violations.
For example, with increasing the tone of the smooth muscles of the intestines, the bronchi or gallbladder, the organs are strongly compressed, characteristic spastic pain appear and the promotion of their enlightenment is disturbed. That is, the intestine is delayed the promotion of the food lump, it ceases to relete the bile from the gallbladder, and the required amount of air cannot pass through the bronchi. In addition, any spasm of internal organs is accompanied by pain syndrome of various intensity. Papaverin removes spasm, relaxes organs, thereby restoring their function and binding pain syndrome. Since the drug is not elected, he effectively stops spasm and pain of any internal organ, and therefore applied very widely. In principle, Papaverin has the same properties and therapeutic effects as the well-known but-shp.
Papaverin has a relaxing effect on the internal organs, since it affects smooth muscles and does not affect the transverse-striped. The fact is that on the human body and in the heart there are only cross-striped muscles, which have other properties and react to completely different irritants and substances. Therefore, antispasmodics acting on smooth muscles do not affect the reduction of skeletal and heart muscles. Thus, Papaverin is able to remove spasm and relax the muscles of internal organs without affecting myocardium and muscles of the body.
Summing up the effects described, the following main therapeutic effects of papaverine can be distinguished:
Papaverin is quickly absorbed into the bloodstream at any route of administration (tablets, rectal candles, intramuscular injections) and is excreted by the kidneys. Half of the administered dose of the drug is output after 0.5 - 2 hours.
Tablets, injections and pipaverin suppositories are shown in use in the following diseases and states:
In case of spasms and spastic pains of internal organs, adults and adolescents are recommended to take papaverin at 40 - 60 mg (1 - 1.5 tablets) 3-4 times a day. Children should give pills with a special children's dosage of 10 mg. And the dosage of papaverine for children is determined by age:
Adults and adolescents over 10 years old, the solution is introduced 2 - 4 times a day, and for children under 10 years old - 2 times a day. The single dosage of papaverine is determined by age:
For subcutaneous or intramuscular administration, primarily choose the injection site. Intramuscularly optimally enter the solution into the upper-block outer surface of the hip or the outer upper part of the shoulder, and subcutaneously to the area around the navel. Before performing injection, the skin is wiped with an antiseptic, after which the desired amount of solution is gained into the syringe and introduced into the prepared place. For intramuscular injection, the needle is introduced deep into the fabric perpendicular to the surface of the skin. And for subcutaneous injections, first capture approximately 1 cm of the skin with a large and index finger, making a fold from it. After that, the syringe needle is set to approximately at an angle of 45 o to the skin surface and introduced into this fold. The solution is released in the tissue and gently take out the needle, after which the injection site is again wiped with an antiseptic. Each time you can enter a solution to a point, which is at a distance of at least 1 cm from other traces from past injections.
For intravenous administration, it is necessary first the desired amount of papaverine dilute in 10-20 ml of physiological solution. Then this mixture is administered intravenously, slowly. Intravenous injections should be performed only in the hospital, and the subcutaneous or intramuscular can be done at home on their own, if a person has mastered their technique and does not experience fear.
The maximum allowable single dosage of papaverine is the greatest dose specified for each age multiplied by four. That is, for an adult, the maximum allowable one-time dosage is 60 * 4 \u003d 240 mg, for a child from 10 to 14 years - 20 * 4 \u003d 80 mg, etc. The maximum allowable daily dosage is equal to the maximum one-time multiplied by three.
If it is necessary to quickly achieve the therapeutic effect, especially in the first days of exacerbation of the disease, then injections should be used. After 2 - 3 days, if a person can swallow, should be replaced by the injections with pills or rectal candles. The entire course of therapy is not recommended using subcutaneous or intramuscular injections, as it entails large risks compared to the reception of tablets. Therefore, injections should be set only if the candles and tablets cannot be applied for any reason. In general, doctors recommend to be guided by a simple rule in the choice of the form of the drug - always use either candles, or tablets, and shots apply only if it is necessary to obtain a rapid therapeutic effect, but at the first opportunity to replace them with pills or suppositories.
If a person suffers from the gastrointestinal spasms, it can use papaverine both in candles and in tablets, based exclusively on personal preferences. However, it should be remembered that when using Papaverin candles, the clinical effect comes faster than from tablets. Therefore, if you need to get a quick effect, it is better to use candles. It is also recommended to choose candles if a person for any reason cannot swallow pills.
In spastic pains in the urinary system organs, the optimal option is papaverine suppositories, since when they were introduced into the rectum, the active substance very quickly reaches the affected tissues and has a powerful therapeutic effect. If for some reason the candles are impossible to enter the rectum or difficult, then it should be replaced with pills.
In children, it is recommended to use papaverine in the form of suppositories or special children's tablets with a low dosage of active substance in 10 mg. Do not have children to give halves or quarters of papaverine pills for adults, which contain 40 mg of active substance.
Papaverin is not a drug intended for long term applications, so it is used exclusively for one-time removal of spastic pains against the background of the exacerbation of the disease or state. This means that independently tablets, candles or injections of papaverine can be used within 2 - 3 days, after which the improvement is required to appear, expressed in the decrease in spastic pains and unpleasant sensations in the localization of the pathological process. If there is no improvement, then immediately consult a doctor, as this may indicate the development of severe surgical pathology, for example, appendicitis, bleeding, peritonitis, etc.
For the purpose of the doctor, Papaverin is usually used within 7 - 14 days or a little longer, right up to completely relieve painful spastic pain. If a person has been suffering from any chronic disease for a long time, for example, cholecystitis, it perfectly knows the symptoms of its exacerbation and the dynamics of improvements advancing against the background of admission of papaverine, and therefore can independently determine the duration of the drug.
If a person faced spastic pain for the first time, then the first course of therapy should be carried out exclusively under the supervision of a doctor and independently fix their own sensations, as well as a positive trend. In the future, when aggravating the disease, the relief of spasms will also be made by antispasmodics, and their dynamics will not differ fundamentally from the one that was fixed for the first time. And a person who remembers the dynamics of reducing spastic pain and normalization of the state, during periods of exacerbation in the future will be able to independently control how correctly the treatment is going, without visiting the doctor for this and does not go to the hospital. In addition, he will be able to record any distinctive manifestations of treatment dynamics and report them to a doctor who, in turn, will be aiming to look for their cause and engage in the problem of diagnosing a combined or atypical pathology.
In addition, but-shap with papaverine is often used to prepare the cervix to childbirth, for which women take 1 tablet or administer 1 candle of each drug 2 times a day for 2 weeks before the expected date of delivery. This practice is widespread, however, these drug preparation drugs are more harmful than good, since just before childbirth, when the uterus should actively shrink and prepare, it is artificially "inhibited by" spasmolitis, relaxing muscles and reducing the tone. As a result of the use of but-ships with papaverine "For the preparation of the cervix" increases the likelihood of the weakness of generic activity and, accordingly, the use of rhodtle, relativesexpension and the imposition of obstetric tongs or vacuum. That is, there is no preparation of the cervix, but the oppression of generic activity.
The use of but-ships with papaverine does not reduce the risk of breaks, which in most cases depend only on competent knowledge of the childhood by the doctor. And for the preparation of the cervix to childbirth, which is carried out only during the rejunction or necessity of urgent delivery against the background of the threat of mothers's life, completely different drugs are used (soda, etc.) and non-drugs (laminaries, Foley catheter, etc.).
The kids of the first year of life, Papaverin is used mainly to relieve spastic pain and intestinal colic, and in children of older age - for removing bronchospasm, as well as in complex therapy of pancreatitis, liver colic and urethra spasms. In addition, if a child has a high temperature and white, cold hands and legs, then papaverin is given to expand the vessels for 15 to 20 minutes to the antipyretic drug. In a situation where the hands and feet are cold, and the temperature is very high, antipyretic without prior admission of antispasmodics (papaverine, but-shops, drootaverine, etc.) will not act, because the narrowed, spashed vessels will not give excess warmth and cool the body .
Papaverin in children is used in all three dosage forms in the dosages depending on age:
This article allows you to familiarize yourself with the instructions for the use of the drug. Papaverine. There are reviews of site visitors - consumers of this medicine, as well as the opinions of doctors of specialists in the use of Papaverin in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Papaverin in the presence of available structural analogs. Use for the treatment of spasms in adults, children, as well as in pregnancy and breastfeeding.
Papaverine - Miotropic spasmolitic. Reduces the tone of smooth muscles of internal organs (gastrointestinal tract, respiratory, urinary, sexual system) and vessels. Causes the expansion of the arteries, contributes to an increase in blood flow, incl. cerebral. It has a hypotensive effect.
In high doses, reduces the excitability of the heart muscle and slows down intracardiac conductivity.
When applied in medium therapeutic doses, the action on the CNS is expressed weakly.
Pharmacokinetics
Bioavailability is 54%. It is well distributed in the body, penetrates through histohematic barriers. Metabolized in the liver. Exammed by the kidneys in the form of metabolites. Completely removed from blood during dialysis.
Indications
As a subsidiary for premedication.
Forms of release
Tablets 40 mg.
Candles for rectal use of 40 mg.
Solution for injections (injections in ampoules) 20 mg / ml.
Instructions for use and dosage
Inside - 40-60 mg 3-5 times a day. Rectally - at 20-40 mg 2-3 times a day.
With intramuscular, subcutaneous or intravenous administration, the one-time dose for adults is 10-20 mg; The interval between the introductions is at least 4 hours. For elderly patients, the initial one-time dose is not more than 10 mg. For children aged 1 to 12 years, the maximum one-time dose is 200-300 mg / kg.
Side effect
Contraindications
Application in pregnancy and breastfeeding
During pregnancy and during lactation (breastfeeding), safety and efficiency of papaverine is not installed.
special instructions
C care to apply under states after the cranial injury, with chronic renal failure, in case of insufficiency of the function of adrenal glands, hypothyroidism, prostate hyperplasia, religative tachycardia, shock conditions.
Intravenously should be introduced slowly and under the control of the doctor.
During the treatment period, the use of alcohol should be excluded.
Medicinal interaction
With simultaneous use with anticholinergic agents, it is possible to enhance anticholinergic effects.
It is believed that with simultaneous use with alprostadyl, there is a risk of developing priapism.
There are reports of reducing the efficiency of levodopes during its simultaneous use.
Reduces the hypotensive effect of methyldopes.
Analogs of the drug Papaverin
Structural analogues for the acting substance:
In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.
Publication date: 26-11-2019
Papaverine (Papaverine) is one of the oldest drugs tested for many decades. At the same time, the drug still effectively removes the spasms of the smooth muscles of internal organs. Papaverin tablets are publicly available and are often used in the treatment of respiratory, digestive, cardiovascular, urogenital systems in adults and children.
Registration certificate: №78 / 368/6.
Anato-therapeutic-chemical classification code: A03AD01.
The main indications for the use of papaverine - muscle spasms appearing in the following diseases:
Papaverin is used as a spasmolytic agent in men in the treatment of impotence. Medication is sometimes used by anesthesiologists in surgical practice in the preparation of patients to operations. Due to the fact that the tone of the muscles of the breathing apparatus decreases, the body is better to transfers anesthesia.
Papaverin is produced by the pharmaceutical industry in 3 dosage forms. It:
The active ingredient of the drug is papaverine hydrochloride (Papaverine Hydrochloride), which refers to the group of synthesized opioid alkaloids.
In natural conditions, they are produced in opium varieties of poppy. In white, slightly bitter adult tablets contain 40 mg of active chemical compound, for children - 10 mg. They are packaged in blisters of 10 pieces.
Support components Tablets:
Pharmacodynamics. The drug is included in groups of vasodilators and myotropic spasmolitics, because It has both vasodilators and anticonvulsant action. In addition, the medication has a light anesthetic and hypotensive effect.
After the content of the papaverine hydrochloride in the blood reaches the therapeutic concentration, the phosphodiesterase enzyme loses its activity, less calcium ions becomes in the body, and smooth muscles relaxes.
The medicine is stopped by the spasms of smooth muscles and pain in the brain area, bronchi, heart, gastrointestinal tract, kidneys, gall and bladder, uterus. At the same time, the motor activity of a person is fully maintained.
Due to the extension of vessels, blood circulation is improved and blood pressure decreases. Papaverin, used in large doses, has a sedative (soothing) action.
Pharmacokinetics. The biological accessibility of the medication is 54%. The active substance is well absorbed and, overcoming histohematic barriers ("filters" between blood and tissue fluid), quickly spreads in the body. The decay of papaverine occurs in the liver. Half-exploration time - from 0.5-2 to 24 hours. Metabolism products are removed mainly through the kidneys, and completely - when conducting dialysis.
The decay of papaverine occurs in the liver. Half-exploration time - from 0.5-2 to 24 hours.
According to the instructions for use, the medication should be taken in accordance with the scheme appointed by the attending physician, taking into account the diagnosis, the severity of the pathology, the presence of concomitant diseases and the age of the patient. Tablets swallow entirely by drinking water.
Adults and adolescents over 15 years old are most often prescribed by 40 mg of Papaverin in the morning, at lunch and evening. With strong spasms and pains - 40-60 mg 3-4 times a day.
One-time doses of the drug for children are determined by age:
You can apply a medication independently of meals as soon as spasms or pain appear. If they often occur in the gastrointestinal tract, it is advisable to take papaverine 20-30 minutes before meals. Then, when suppressing painful symptoms, food becomes full.
Maximum preparation begins to act about 30 minutes after receiving tablets. The therapeutic effect of this tool is not so intense, as, for example, a but-shop. Since severe pains of papaverine will be partially engaged, its action is often reinforced by simultaneous reception of paracetamol or aspirin.
For each patient, the course of therapy should be selected individually. The duration of treatment depends on how pain or spasms quickly stop. In case of diseases in the acute stage, papaverin takes 3-5 days, with chronic pathologies - from 1 to 3 weeks.
Medication should be given with special precautions to children. For a child, the tablet can be crushed, add some water to the powder and mix.
With sharp pain and spasms, the tablets should be replaced by injections. Intravenously enter the drug is needed slowly and under the supervision of the attending physician. It is not recommended to carry out treatment only by injections, because With this method, the introduction of the drug increases the risk of side effects. Injections help to quickly reach the healing effect, but then you should apply either tablets or suppositories.
It should be borne in mind: the activity of the drug is reduced during smoking.
When entering the fetus, the preparation in tablets is prescribed extremely rarely, candles are most often used to remove spasms and hypertonus of the uterus. Since both the danger and the harmlessness of papaverine during pregnancy and during breastfeeding are not proven, the medication should be applied only on strict indications. It is recommended to take a child from the mother breast for the treatment of this drug.
Reception of medicine is contraindicated, if the child is less than 6 months.
Medication is not prescribed to patients over 60-65 years due to the risk of side effects in pronounced form. Especially often the body temperature rises.
The drug is contraindicated, if the patient suffers from severe liver failure.
Papaverin can not be prescribed with severe renal failure.
Negative consequences of drug treatment occur in patients extremely rare. Most often, the cause of side effects becomes non-compliance with the dosage of medication. At the same time may appear:
The grounds for prohibiting the reception of the drug:
With caution, it is necessary to assign papaverin at the following diagnoses:
The medicine does not reduce the concentration of attention and speed of reactions, therefore does not affect driving any types of transport.
The therapeutic effect of papaverine amplifies:
Reduce the action of antispasmodics:
Symptoms of dosage excess:
Antidote no. Symptomatic treatment is carried out: washing the stomach using polysorba or activated carbon and milk.
The symptom of excess dosage is
worsenness of view, two-way images in the eyes.
The medication is sold on the recipe.
The estimated cost of papaverine in tablets - 25-99 rubles.
Store the medicine should be kept at room temperature in a place protected from children.
The drug is suitable for use for 5 years.
Papaverin produces the following pharmaceutical enterprises:
Structural analogues for the acting substance - candles with papaverine hydrochloride.
Structural analogues for the acting substance:
Preparations similar to the reserved:
Papaverin is an antispasmodic agent that affects the condition of the smooth muscles of vessels and internal organs. Under the influence of papaverine, your muscles relax, the vessels will expand and the pain will pass.
Release form:
Motropic antispasmodic, vasodilator and hypotensive agent. Papaverin slightly reduces blood pressure. If you take papaverin in increased quantities, the sensitivity of myocardium is somewhat reduced. In addition, relaxation and calm comes from large quantities of papaverine.
Spasms of smooth muscles of the abdominal organs, bronchi, peripheral vessels, brain vessels, kidneys; angina (as part of combined therapy).
If you suffer in smooth muscles with spasms with colitis or cholecystitis, kidney colic, pylorospasm, find out your attending physician about Papaverin. Perhaps this drug will bring you relief. But papaverine is effective not only in spasms in the organs of the gastrointestinal tract. In the spasms of the vessels (including those that feed the brain and the heart), as well as spasms of the muscles of the respiratory organs, this tool also acts well.
In the treatment of papaverin, the use of alcoholic beverages is completely eliminated. Smoking reduces papaverine efficiency. The simultaneous use of papaverine and drugs against Parkinson's disease reduces the effectiveness of the latter.
When applying the drug Papaverin, patients have noted the development of such side effects:
With a quick / in the introduction, as well as when using high doses: the development of AV blockade, heart rate disorders is possible. Do not use this tool without appointing a doctor, since Papaverin has a number of contraindications. And in some diseases, doctors prescribe papaverine with very long courses. During this long treatment it is necessary to adjust dosage. It is unlikely that you yourself can be so qualified traced the course of your own disease.
Inside - 40-60 mg 3-5 times / day. Rectally - at 20-40 mg 2-3 times / day.
If you accidentally drank the excess pill papaverine, then you need to take activated carbon, and also monitor your arterial pressure. It can fall too low. Perhaps you will pull to sleep. In this case, it is necessary to adopt the drug that increases blood pressure.
In addition to categorical contraindications, there are conditions in which the use of papaverine requires special observation by doctors. These are patients who have suffered cranial injuries, with impaired adrenal work, with hypothyroidism, prostate adenoma, some of the heart work disorders, as well as in a state of shock.
Dosage form: & nbspinjection Structure:1 ml of the drug contains:
Active substance:
Papaverin hydrochloride - 20 mg
Excipients:
Methionine - 0.1 mg
Dinatari Edetat (Trilon B) - 0.05 mg
Water for injection - up to 1 ml
Description:Transparent colorless or with a weak greenish yellow tint liquid.
Pharmacotherapeutic Group:Antispasmodic. ATH: & NBSPA.03.A.D. Papaverin and its derivatives
A.03.A.D.01 Papaverin
Pharmacodynamics:Papaverin reduces the tone of smooth muscles and has a vasodilatory and antispasmodic effect. It is a phosphodiesterase enzyme inhibitor and causes intracellular accumulation of cyclic 3.5 - adenosine monophosphate, which leads to a violation of the reduction of smooth muscles and relaxing them in spastic states. The effect of papaverine on the central nervous system is expressed weakly, but in large doses, it has a sedative effect. In large doses reduces the excitability of the heart muscle and slows down intracardiac conductivity.
Pharmacokinetics:Bioavailability - 54%. Communication with plasma proteins - 90%. Horonia is distributed, penetrates through histohematic barriers. Metabolized in the liver. Half-life (t 1/2 - 0.5 - 2 h (increase of up to 24 hours). Exammed by the kidneys in the form of metabolites. Completely removed from blood during hemodialysis.
Indications:The spasm of the smooth muscles of the abdominal organs (cholecystitis, pylorospasm, spastic colitis), bronchi (bronchospasm), peripheral vessels, brain vessels, urinary tract (renal colic). As a supporting agent for premedication.
Contraindications:Hypersensitivity to the components of the drug, imparation of atrioventricular (AV) conductivity, glaucoma, severe liver failure, comatose state, respiratory depression, elderly age (risk of hyperthermia), children's age (up to 6 months).
Carefully:With caution and in small doses, a drug should be prescribed to weakened patients, as well as patients with cranial-brain injury, impaired kidney function, hypothyroidism, insufficiency of adrenal function, prostate hypertrophy, as well as patients with supertoday tachycardia and in a state of shock.
Pregnancy and lactation:During pregnancy and in the period of breastfeeding, the safety and efficacy of the drug is not installed. The use of the drug during pregnancy and lactation is possible only by appointing a doctor if the estimated benefit for the mother exceeds the potential risk to the fetus or child.
Method of use and dose:The drug is injected intramuscularly, subcutaneously or intravenously.
One-time dose for adults is 20 - 40 mg (1-2 ml of 20 mg / ml solution), the interval between the introductions is at least 4 hours. Intravenous administration produce pre-dulling 20 mg / ml solution of the preparation of 10-20 ml of isotonic sodium chloride solution. For children aged 6 months to 12 years, the maximum one-time dose is 0. 3mg / kg body weight.
In children aged 12 to 18 years, the dispensing mode corresponds to the dosing regime in adults.
Procedure for working with a polymer ampoule:
1. Take an ampoule and shake it while keeping for the neck.
2. To surpasses with an ampoule with hand, while the drug should not be released, and rotate and separate the valve.
3. Through the resulting hole immediately connect the syringe with an ampoule.
4. Turn over the ampoule and slowly dial its contents into the syringe.
5. Put the needle on the syringe.
Side effects:The frequency of adverse reactions is presented according to the following classification of the World Health Organization (WHO): Often - 1 - 10%, infrequently 0.1 - 1%, rarely - 0.01 - 0.1%, very rarely - less than 0.001%, including individual cases.
From the side of the skin:
Often - skin rash (usually erythematous, urticaria), infrequently skin itching, rarely increased sweating.From the digestive system: Often - nausea, constipation, infrequently - increasing the activity of "liver" transaminase.
From the nervous system: Often - drowsiness.
From the side of the cardiovascular system: Often - reduction in blood pressure, infrequently - ventricular extrasystole.
From the side of the blood: Very rarely - eosinophilia.
With quick intravenous administration, as well as the use of high doses, the development of an atrioventricular blockade is possible, heart rate disorders.
Overdose:Symptoms: Diplopia (shots in the eyes), weakness, reduction in blood pressure, drowsiness.
Treatment: symptomatic (maintaining blood pressure). Interaction:Papaverin reduces the anti-paquinsonic effect of Levodopa. In combination of bbitrats, the spasmodic effect of papaverine is intensified. With co-use with tricyclic antidepressants, Novocainamide, reserpine, quinidine, it is possible to strengthen the hypotensive effect. With simultaneous use with anticholinergic agents, it is possible to enhance anticholinergic effects. With the simultaneous use of E alprostadyl, there is a risk of developing priaprism. Reduces the hypotensive effect of methyldopes.
Special instructions:Intravenously drug should be introduced slowly and under the control of the doctor.
During the treatment period, the reception of alcohol must be excluded.
The effectiveness of the drug decreases with tobacco.
Impact on the ability to control the transc. cf. And Meh.:When applying the drug, care must be taken when managing motor transport and classes with potentially hazardous types of activities that require increased concentration and speed of psychomotor reactions, as the following side effects are possible: reduction of blood pressure, drowsiness, heart rate disruption.