Studying the immune system human organism It began not so long ago. Modern medicine reached great success in this direction. Many diseases have established immune nature. Almost all organs are subject to such pathologies. Often the target becomes the intestines. Now there are increasingly two characteristic diagnosis: ulcerative colitis and Crohn's disease. Effective tool In the fight against these ailments is modern drug Pentas.

Anti-inflammatory mechanism Pentas

Thanks to immune system The person managed to successfully exist on the planet, inhabited by bacteria and viruses. Immunity omnipresent. His fighters supervise all cells and tissues. Their main task is to identify and destroy alien objects in time. To protect the body from viruses, bacteria and their own changed structures, there are white blood cells of leukocytes. They either directly destroy pathogenic microorganisms, or form special antibody proteins.

Leukocytes are the main fighters of immunity

A peculiar protective mechanism is an inflammatory response. Her task is not to give hostile agents to break through deep into the body. Not only leukocytes are played here, but also special chemicals. Most are relatives of arachidonic acid. The pentas preparation affects all sides of immune and inflammatory reactions. It makes leukocytes less actively look for their opponents and produce antibodies. In addition, less arachidonic acid and other inflammation participants are formed under the influence of this.

Pentas has an anti-inflammatory action

Ulcerative colitis - video

Composition and form of release

Pentas preparation ( latin name Pentasa) can be found in a pharmacy in two dosage forms: the granules for receiving inside and rectal candles. In both cases active component is a substance Mesalazin. It affects the immune response of the body and the flow of inflammatory reactions. For the preparation of candles and granules, the manufacturer uses several additional components.

Pentas are produced in the form of granules for reception inside

Composition of granules and suppositories - Table

Therapeutic use of pentasy

Mesalazine contained in the pentase is prescribed mainly to treat immune bowel diseases:

• non-specific ulcerative colitis. Modern medicine has established the immune nature of the disease. But the main reason for such aggressive behavior of immunity still requires research and evidence. A typical feature line is the inflammation of the large intestine. It is accompanied by the appearance of abdominal pain and liquid stool with blood. Pentas, acting in the intestine, contributes to the healing of ulcers and sacrificing inflammation;

  Ulcerative colitis - immune intestinal disease

• crohn's disease. This is another immune disease of the intestine. It can localize in any of its departments - thin, thick and rectum. And in this case, the pentas will help cope with the symptoms of the disease.

  In case of Crohn's disease, the intestinal mucosa resembles a cobblestone bridge

Crohn's disease - video

Contraindications and unwanted reactions

Contraindications to the appointment of the drug a bit:

When accepting pentas, like any medicine, adverse reactions are possible. Most are quite rare:

Harfish - video

Pentas is prohibited for use in pregnant and lactating women. Granules are permissible to use for the treatment of children over two years. Rectal suppositories are prescribed only to adult patients.

Features of application

Granules are prescribed to adults and children over two years. The drug in this form is advisable to take entirely without cursing. If the patient is difficult to swallow the granules in this way, they can be dissolved in boiled water or fruit juice. To drink the resulting agent is necessary immediately after cooking. The dosage will determine the doctor individually. It should be borne in mind that, as a rule, treatment of ulcerative colitis and crown disease is a long-term process, often lifelong.

Pentas suppositories are prescribed only to adult patients. For hygienic use in the kit includes disposable attacks. It must be borne in mind that the duration of medication in the rectum should be at least ten minutes. If necessary, you should enter a new candle instead of the time delayed. The drug does not cause drowsiness. In addition, the medicine is successfully applied at sugar diabetes. Pentas has the ability to interact with some drugs:

In these cases, a dose correction may be required.

Preparations with a similar action

Pentas refers to prescription drugs. The price of the drug depends on the form of release. 50 bags of granules stand from 5763 to 6566 rubles. The price for packing suppositories (28 pieces) ranges from 2741 to 2865 rubles. There are medications with a similar active substance from different price categories.

Preparations containing Mesalazin - Table

Last update of description by the manufacturer 24.05.2005

Filtered list

Active substance:

ATX

Pharmacological group

Nonological Classification (ICD-10)

Composition and form of release

in blister 10 pcs.; In a box of 5 or 10 blisters.

complete with rubber attacks; In box 28 sets.

pharmachologic effect

Reduces the formation of leukotrienes and cytokinins, neutralizes free radicals, inhibits hemotaxis leukocytes.

Indications of the drug pentas ®

Nonspecific ulcerative colitis, incl. Damn, Crohn's disease.

Contraindications

Hypersensitivity (including to salicylate or other components of the drug); pronounced violations of the liver and kidney function.

Application in pregnancy and breastfeeding

When pregnancy and during breastfeeding period, prescribed only in cases where the positive effect exceeds the risk of developing possible side effects.

Side effects

Feeling of discomfort in the abdomen, nausea, vomiting, headache, diarrhea, skin rash in the form of wretched or eczema; Very rarely - pain in the muscles and joints, temporary hair loss, impaired liver and kidney function, pericarditis, myocarditis, pancreatitis, changes in blood formula (leukopenia, granulocyptopenia, thrombocytopenia, anemia).

Method of application and dose

Inside, not chewing, if possible, swallowed entirely (to facilitate swallowing, they are divided into several parts or dissolved in water or juice immediately before taking), the dose is selected individually. Adults, with exacerbation of ulcerative colitis or Crohn's disease - usually up to 4 g / day in several techniques; Supporting dose - 2 g / day in several techniques for ulcerative colitis and 4 g / days in several techniques for crown disease; Children over 2 years old - usually 20-30 mg / kg / day in several techniques.

Rectally, adults - 1 sore. 1-2 times a day in a straight intestine to the cessation of muscle thorough resistance (the intestines empty before the introduction, to facilitate the introduction of suppository, they are moisturized with water, to ensure hygiene use rubber attacks).

If for 10 minutes the suppository will be displayed, you should enter another suppository.

Precautions

At the beginning and during the entire course of treatment, the composition of the peripheral blood, the level of urea, creatinine should be regularly monitored. In the case of severe pathological changes in blood composition (increased bleeding, subcutaneous hemorrhages, pain in the throat, fever), the development of pericarditis, myocarditis and acute intolerance syndrome The drug must be canceled. It is not recommended to appoint children up to 2 years.

Storage conditions PENTAAS ®

Keep out of the reach of children.

The shelf life of Pentas ®

Do not apply after the expiration date indicated on the package.

Synonyms of nosological groups

In which dose prescribe a "pentas" medicine? Instructions for use, reviews and composition of the drug are considered below. Also in the materials of the article provides information on the forms of release of this medication and its properties.

Composition, form of medication

There are several forms of release of the drug under consideration. Imagine them right now.

The preparation of "pentas" - tablets (500 mg, 100 mg) of prolonged action. They have white color with a grayish tint, as well as with numerous light brown splashes, correct round shape, with risky, chamfer and inscriptions on both sides.

The active element of this medication is Mesalazin. Also, the equipment includes inactive ingredients in the form of povidone, ethylcellulose, magnesium stearate, talc and cellulose microcrystalline.

For sale the drug "Pentas" (tablets), photo of which is presented in the article, enters blisters, which are in packages of cardboard.

It should also be noted that the medication under consideration can be purchased in the form of candles, the granules of prolonged action and a rectal suspension.

Pharmacology of Medical Preparation

What is a medicine "Pentas"? The application instruction states that this is a means with anti-inflammatory effect and applied to the treatment of a nym and

Anti-inflammatory properties of this drug are manifested only when local use. Such an action is caused by the synthesis of leukotrienes and prostaglandins, as well as inhibiting the activity of lipoxygenase (neutropyl). In addition, this remedy can slow down the secretion of immunoglobulins lymphocytes and inhibit the degranulation, migration and phagocytosis of neutrophils.

Features of the intestinal means

The "pentas" medication (tablets), the composition of which was presented above, exhibits pronounced antibacterial activity against some kokkops and intestinal sticks. It also has an antioxidant effect due to the ability of the active substance to bind to free radicals (oxygen) and destroy them.

The correct application of this tool significantly reduces the risk of recurrence during the Crohn disease, including people with Ileis (with a long duration of the disease).

Principle of Medication

How does the Pentas medicine act? Instructions for use argues that therapeutic effect This drug is manifested immediately after the local contact of Mesalazin from the intestinal mucosa.

After acceptance oral administration The tablet immediately disintegrates into microgranules, which act as independent forms and slowly release the active substance - Mesalazin. This ensures the effectiveness of the medication during the 12-rings to the rectum in any pH indicators.

Pharmacokinetics means

How is the absorption of the medication "Pentas"? Instructions for use reports that the microgranules of the broken tablets reach a 12-risk intestine during the first 60 minutes.

Approximately 30-50% of the accepted drug dosage is absorbed into thin intestine. The mesalazine connection with plasma proteins is 43%, and N-acetyl-five-aminosalicyl acid acids - 73-85%.

Mesalazin, and its derivatives do not penetrate through the BC. The cumulative properties of the drug are manifested only when using high dosages (about 1500 mg per day).

Mesalazine acetylation is subjected to mucous membranes and liver. This substance is excreted with urine, maternal milk and feces.

Indications for use medication

In which cases can be shown the "Pentas" medication (tablets)? Expert reviews say that this medication manifests itself well with:

Bans to the use of the drug

Under what states should such a means like "pentas"? The instructions (tablets and other forms of the drug have the same contraindications) indicates the following prohibitions:

• diathesis hemorrhagic;
• blood diseases;
• lactation period;
• ulcer bust organs;
• last 2-5 weeks of pregnancy;
• lack of glucose-6-phosphatehydrogenase;
• age up to two years;
• renal failure heavy;
• increased sensitivity to agents;
• hepatic insufficiency heavy.

With extreme caution, the drug under consideration should be used in the first trimester of pregnancy, as well as during liver and renal failure.

Medication "Pentas": instructions for use

The choice of dosage form of this drug depends on the localization of the main pathological process, as well as the length of the intestinal lesion.

Suppositories "Pentas" and suspension are prescribed with distal forms of illness (proctosigmith). In this case, the candles are used three times a day of 500 mg.

How do pentas oral preparation (tablets) prescribe? The application instruction states that such a type of medication is recommended only with common forms of diseases. For the prevention of relapses in Crohn's disease, medication is used four times a day (1 g of Mesalazin). As for the prevention of the recurrence of the Nab, then in this case the drug is prescribed three times a day of 500 mg.

When aggravating the disease, the course of therapy should last 8-12 weeks. At the same time, every day should be taken at 400-800 mg of medication (three times a day).

For severe course Diseases may increase the daily dosage until 3-4.

Tablets "Pentas" It is advisable to take immediately after the meal, not chewing and drinking with ordinary water.

Actions side character

In some cases, the medication in question causes the following side effects:

It should also be noted that against the background of the admission of this drug, the patient may be observed: Olisgospermia, alopecia, photosensitization, weakness in the limbs, a lupus-like syndrome, a decrease in the production of tear fluid, steam.

Overdose medicinal drug

Overdose under consideration manifests itself increased sleepy, nausea, gastralgia, vomiting and weakness in the whole body. To eliminate such symptoms, timely washing of the stomach is required, as well as the appointment of laxative medicines and the conduct of fairurome therapy.

Drug interaction

The "pentas" medicine is capable of slowing the speed of the absorption of cyanocobalamin. Mesalazin also increases the effectiveness of urrises (including channel secretion blockers).

It is impossible not to note that this drug Increases ulcenerity of glucocorticosteroids, weakens the effect of rifampicin, strengthens the toxicity of methotrexate and has a hypoglycemic effect on derivatives of sulfonylurea, spironolactone, sulfonyllamides and furosemide.

Special Information

Sometimes on the background of the use of the drug under consideration in patients, urine staining is observed and contact lenses In a yellowish-orange tint.

In the process of treatment, Mesalazin needs permanent medical control over the work of the patient's renal system. It should also regularly analyze the urine of the patient and its blood (during the entire course of therapy, as well as after its completion).

The probability of appearance adverse Reactions Against the background of taking this medication, those who are a "slow acetyator" increase.

Under development acute syndrome The intolerance of the active ingredient the drug "Pentas" is immediately canceled.

Similar medicines and consumer reviews

Do you know about how to replace the medication considered? This should be informed by the attending doctor. As a rule, the analogues of this agent include the following drugs: "Meallak", "Salozinate", "Salofalc", "Mesavant", Mesalazin, Asol.

Structure

In 1 tablet of the prolonged action, 500 mg of the Mesalazin active substance was concluded.

Auxiliary components: ethylcellulose, talc, povedium, microcrystalline cellulose, magnesium stearate.

Pentas pentas pants contain 1000 mg and 2000 mg of mesalazine in 1-2 gram sachets, respectively.

Auxiliary substances: ethylcellulose and pose.

In one pentas suppository, 1000 mg of the active component of the Mesalazin is contained.

Additional components: Talc, Pisidone, magnesium stearate, macrogol.

pharmachologic effect

Pentas has a pronounced anti-inflammatory effect. The drug is not peculiar to the system action, it shows its activity in the inflamed sections of the intestine.

Hummer hemotaxis leukocytes, the drug prevents their migration to the pathological center, thus reducing infiltration. The synthesis of inflammatory mediators, in particular, prostaglandins, leukotrins and other arachidonic acid metabolites decreases. Pentas reduces the amount of floor products, inhibiting their damaging effect on the bowel tissue.

Clinically supporting intake of pentas is associated with a low risk of colorectal cancer.

Indications for use

The tableted and granulated form of pentas is used in the therapy of a light and moderate clinical degree of non-specific ulcerative colitis.

The high efficiency of the pentas suppositories was shown in the treatment of ulcerative proctitis.

Mode of application

Papers or pentas pellets are taken inside, not chewing. For better swallowing, they are powered by water or juice. Dose of the drug appoints the attending physician individually.

Adults for the treatment of recurrence of regional enteritis or a nap are prescribed 4 g per day. Supporting dose for Crohn's disease - 4g pentas, with a nym - 2 g. The daily dose is divided for convenience to several techniques.

Children use 30 mg / kg of pentas body weights also for several receptions per day.

When using rectal suppositories are injected into the anal hole of 1-2 suppository per day until the resistance of the circular muscle is stopped. Before the introduction to make a cleansing enema. Rubber attacks that are completed with the drug are designed to provide proper hygiene during the procedure. For easy introduction of suppositories, they are wetted with water.

With spontaneous removal of the means from the intestine for 10 minutes, manipulation should be repeated.

Side effects

The side effects of the action of pentas from the head of the gastrointestinal tract are manifested in the form of abdominalgiy, dyspeptic disorders, stool disorders, nausea, sometimes vomiting, in biochemical analysis The activity of hepatic enzymes can increase.

CNS disorders are manifested in the form of dizziness, discordination, tingling and tremor limbs, noise in ears and depression.

From the side of the excretory system, proteinuria, hematuria may occur, urination disorders up to Anuria.

Allergic reactions to the reception of pentas are manifested by Exanthem, itching and burning skin.

Bradycardia, subjective feeling of heart failure, chest pain, shortness of breath, reduction or rising garden.

In the analysis of blood, the oppression of all sprouts of blood formation can be detected, immunosuppression and disruption of coagulation.

Less than the reception of pentas causes alopecia and reduce tear.

Contraindications

Pentas is contraindicated in revealed excess sensitivity to the Mesalazin and its metabolites. There is a cross intolerance to salicylate.

The drug is not used in patients with severe dysfunction of the liver and excretory system, impaired blood coagulation, with ulcerative disease.

Not applicable in children up to 2 years.

Pregnancy

Pentas is contraindicated pregnant. Only in the first trimester gestation according to the testimony is possible its use. A month before the reception, the drug is stopped if the course of the disease allows.

Breastfeeding when taking pentas interrupt.

Medicinal interaction

The simultaneous intake of pentas with nastyoid, mercaptopurine and methotrexate increases the toxicity of the latter.

Pentas reduces warfarin efficiency with their parallel use.

The drug potentiates the hypoglycemic effect of sulfonylurea derivatives.

Glucocorticoid carcinogenicity increases with a joint admission with a pentas.

Pentas enhances the effect of anticoagulants.

The clinical efficacy of sulfonamide, rifampicin and thiazide diuretics is reduced under the action of the active substance of the pentas.

The drug oppresses the absorption of cyankobalamin.

The simultaneous reception of pentas with uricosuric means increases their effectiveness.

Overdose

There is a limited number of messages about the overdose of the pentas.

In general, the clinic corresponds to that with excessive reception of salcilate salts. Against the background of dehydration, pulmonary hyperventilation, hypoglycemia and acid-alkaline imbalance are observed.

Treatment of overdose of the drug of symptomatic orientation requires hospitalization to the hospital. Specific antidote is absent.

In the first hours after oral administration, the agent was washed with stomach. Permanent monitoring of braids, level of electrolytes and kidney functions.

Form release

Produced by the pharmacological industry in the form of tablets in a blister pack for 10 pieces each.

Pentas powder granules are concluded in paper sachets in 1 g and 2 g.

Rectal pentas suppositories are equipped with rubber attacks in the amount of 28 pieces.

Storage conditions

Save in factory package when room temperature, not higher than 25 degrees Celsius.

Synonyms

Asaca, Kansalazine, Mesavant, Mealac, Salazoperin, Salazoperidazin, Salofalc, Sulfasalazine, Samiel.

International non-proprietary title

Mesalazin

Dosage form

Tablets with prolonged release 500 mg

Structure

One tablet contains

activeoE Substancesabout -mesalazina 500 mg,

excipients: Povidone, ethylcellulose, magnesium stearate, talc, microcrystalline cellulose.

Description

Round tablets in Krapinka from white-gray to pale brown, with a notch for breaking and embossed "500" and "MG" on both sides of the risks on one side of the tablet and "Pentasa" on the other side of the tablet.

Pharmacotherapeutic group

Intestinal anti-inflammatory drugs. Aminosalcyl acid and similar drugs. Mesalazin.

ATH Code A07ES02.

Pharmacological properties

Pharmacokinetics

After use and dissolution, Mesalazin is gradually released from each microgranules during the passage of the tablet gastrointestinal (Gastrointestinal tract) from duodenal to the rectum with any pH values \u200b\u200bof the intestinal environment. 1 hour after oral administration, microgranules are determined in duodenalistician Regardless of meals. The average passage time in the intestine in healthy volunteers is 3-4 hours. Mesalazine turns into N-acetyl-mesalazine, both presented in the intestinal mucous membrane, and systemically in the liver. Minor acetylation is carried out with the participation of a thick intestine bacteria, as a result of which acetyl-5-aminosalcyl acid is formed. From 30 to 50% of the drug during oral administration is absorbed into thin intestines. Already 15 minutes after reception, Mesalazin is determined in the blood plasma. The maximum concentration of mesalazine in the blood plasma is achieved in 1-4 hours after the use of the drug. The mesalazine concentration in the blood plasma is gradually decreasing, and after 12 hours after use is not determined. The concentration curve of the acetyl mesalazine in the blood plasma is of the same character, but in general it is characterized by higher concentrations and slower elimination. The metabolic ratio in the blood plasma of acetyl-mesalazine to the mesalazine is from 3.5 to 1.3 after oral administration of 500 mg 3 times a day and 2 g 3 times a day, respectively, which displays the dependence of acetylation from the dose. The average stable concentration of mesalazine in blood plasma is 2; 8 and 12 mmol / l after taking 1.5; 4 and 6 g per day, respectively. For acetyl mesalazine, these concentrations are respectively 6, 13 and 16 mmol / l. Mesalazin and Acetyl Mesalazin do not penetrate the hematostephalic barrier. The binding of mesalazine with blood plasma proteins is about 50%, and acetyl mesalazine is about 80%. The half-life of the blood plasma mesalazine is about 40 minutes (clearance after use of 500 mg - 18 l / h), and acetyl mesalazine is about 70 minutes. Since Mesalazine is constantly released when passing through the gastrointestinal tract, it is impossible to determine the half-life after oral administration. The results of the experiments showed that Mesalazin reaches a stable concentration after oral administration within 5 days. After oral administration, Mesalazin and Acetyl Mesalazine are removed with urine and feces (with urine it is predominantly acetyl mesalazine). Mesalazine's bioavailability during oral administration is slightly violated due to pathophysiological processes in acute inflammatory bowel diseases, such as diarrhea and increased acidity. In patients with enhanced intestinal peristaltics, systemic absorption decreases to 20-25% of the daily dose of the drug. Probably, the indicators of the elimination of the substance with urine and feces increase. In patients with impaired liver and kidney function, the lack of rate of removal of the drug may increase the risk of by-referee.

Pharmacodynamics Pentas - Tablets with prolonged release, is mesalazine microgranules covered with ethylcellulose. Mesalazine is an active component of sulfasalazine, which is used to treat ulcerative colitis and crown disease.

According to the results clinical studies, the therapeutic value of mesalazine in oral and rectal use is more likely to local action on inflamed intestinal and gastric fabric than in systemic action.

In all patients with inflammatory diseases of the intestine, an increased migration of leukocytes is observed, an abnormal production of cytokines, an increased production of arachidonic acid metabolites, in particular, leukotriene B4, and enhanced formation of free radicals in inflamed intestinal tissues. The pharmacological effect of Mesalazine In-Vitro and In-Vivo consists in inhibiting chemotaxis leukocytes, decrease in cytokines and leukotriene, as well as the removal of free radicals. At the moment, it is not known which of these mechanisms the most affects the clinical efficacy of Mesalazin.

With ulcerative colitis, the risk of caressing cancer increases (Rural), especially in patients with a common pathological process, during diseases\u003e 8 years, if there is a history of the nearest ROPK relatives, or with a concomitant primary sclerosing cholangitis. The risk of Ropk caused by colitis is 2% for 10 years, 8% for 20 years and 18% for 30 years after the occurrence of ulcerative colitis.

Comparative analysis 9 of non-experimental studies (3 group studies and 6 studies by the method of case-control) 334 cases of Ropk and 140 cases of dysplasia among 1.932 patients with ulcerative colitis demonstrated that in patients undergoing treatment with Mesalazin, the risk of Ropk has decreased by 50%, as well as showed a combined clinical result for Ropk and dysplasia. Reducing the risk of ROPK depends on the dosage, as evidenced by a comparative analysis of studies of daily dosage records, according to which Mesalazine has a chemopregnitative action ≥1.2 g / day. In addition, the chemoprophylaxis is associated with a lifetime dose of Mesalazin (4). Finally, it was discovered that compliance with Mesalazine supporting treatment reduces the risk of ROPK. The effect of mesalazine, identified with the help of experimental models and biopsy of patients, confirms the role of the drug in the prevention of ROPK caused by ulcerative colitis, as well as reducing the number of related and non-related inflammatory process Signal paths involved in the development of Ropk caused by colitis.

Indications for use

Nonspecific ulcerative colitis

Crohn's disease

Method of application and dose

Other treatment must be appointed patients with Crohn's disease that did not respond to daily dose Up to 4 g of Mesalazine for 6 weeks, and Patients with Crohn's disease in the event of an outbreak of the disease, despite the supporting therapy of 4 g Mesalazin per day.

Tablets take inside, not chewing. To facilitate swallowing, the tablet can be divided into several parts or dissolve in 50 ml of water immediately before use.

It is important to regularly take the drug to achieve an optimal effect.

Children. Contraindicated to the children under 6 years old.

Side effects

Often

headache

nausea, vomiting, abdominal pain, diarrhea

skin rash (including urticaria, erythematous rash)

Seldom

dizziness

myocarditis, pericarditis

flatulence , enhance the level of amylase, pancreatitis

pankolit

medical disease

Rarely

Eosinophilia (as a manifestation allergic reaction), anemia, including aplastic, leukopenia (including granulocyptopenia and neutropenia), thrombocytopenia, agranulocytosis, pancytopenia

hypersensitivity reactions

peripheral neuropathy

malgy, Arthralgia

shortness of breath, cough, bronchospasm, allergic alveolol, pulmonary infiltration, lung eosinophilia, pneumonia

increased liver transamamine, signs of cholestasis, hyperbilirubinemia, signs of hepatotoxicity (including hepatitis, cholestatic hepatitis, cirrhosis, hepatic failure)

acute and chronic interstitial nephritis, nephrotic syndrome, renal failure, urine color change, proteinuria, hematuria, oliguria, anouria, crystalluria

Weakness, syndrome, similar to the Red Volcanka

Alopecia

Reducing the products of tear fluid, steam

Oligospermia

Stomatitis

Contraindications

Hypersensitivity to active or auxiliary components

preparation or salicylate

Heavy hepatic and / or renal failure

Blood system disease - ulcerative disease Stomach and duodenum

Bleeding, hemorrhagic vasculitis - glucose-6-phosphate dehydrogenase deficit - childhood up to 6 years - pregnancy and lactation period

Medicinal interactions

Enhances the hypoglycemic effect of sulfonylurea derivatives, ulcenerity of glucocorticosteroids, toxicity of methotrexate. Reduces the activity of furosemide, spiroranolactone, sulfanimamides, rifampicin. Enhances the effect of anticoagulants. Increases the efficiency of uricozeuric drugs (channels of the canal secretion). Slows up the absorption of cyanocobalamin. Mesalazin can weaken the adverse effect of glucocorticoids on the gastric mucosa, can reduce the absorption of digoxin.

special instructions

It is necessary to use the drug to use patients who have allergic to salicylates (on sulfasalazine) in an anamnesis. In the case of such acute symptomssuch as convulsions, abdominal pain, body temperature increase, severe headache, rash reception of the drug must be stopped immediately.

It should be used to apply the drug to patients with impaired liver function. If necessary, before and during treatment, the liver functional indicators should be monitored, such as AT and AST.

It is not recommended to apply the drug to patients with renal failure. The violation of the kidney function in the patient during treatment can be caused by the nephrotoxic effect of Mesalazin. It is necessary to regularly monitor the function of the kidneys, namely, determine the level of creatinine in serum (especially in the initial phase of treatment).

If you suspect the development of myocarditis, pericarditis or in the event of a change in blood composition, treatment should be discontinued. The manifestations of the above adverse reactions can be: in the case of pronounced changes in blood composition - increased bleeding, subcutaneous hemorrhages, pain in the throat and fever, in the case of pericarditis or myocarditis - fever, pain behind the sternum and shortness of breath. Patients whose acetylation process occurs slowly, have increased risk of developing side Effects. It may be observed urine staining and a lacrimal fluid into yellow-orange color, staining of contact lenses. When applied in elderly patients, there is no need to reduce the dose. Pregnancy and lactation period

It is known that Mesalazine penetrates through the placental barrier. Limited information on the use of this substance during pregnancy does not allow to assess a possible toxic effect. Mesalazin enters breast milk at lower concentrations than in the blood of the mother, while the acetyl-mesalazine metabolite is determined in breast milk In the same or more high concentrations. In infants, whose mother used the drug of pentas, adverse effects did not notice, but the available information is limited. During the period of pregnancy and breastfeeding, the drug should be applied with caution and only if possible benefit From the drug will exceed a possible risk.

Features of influence on the ability to manage vehicle or potentially dangerous mechanisms

Given the possibility of developing side effects from the Central nervous system, It should be refracted from driving a vehicle or potentially hazardous mechanisms.

Overdose

Considering unique dosage form The drug in the form of tablets with prolonged release and specific pharmacokinetic properties of mesalazine, only a minor part of the active substance has a systematic effect, so it should not expect the development of symptoms of overdose, even with the use of high doses of the drug.

Symptoms: Nausea, vomiting, gastralgy, weakness, drowsiness.

Treatment: Symptomatic: stomach wash; application of laxatives; Restoration acid-alkaline balance Depending on the clinical situation and replacing the loss of electrolytes with mixed alkalosis / acidosis; replenishment of the volume of fluid under hyperhydrosis, vomiting; In hypoglycemia - the introduction of glucose. Kidney function control.

Release form and packaging