Description of the dosage form

Release form, composition and packaging

Maninyl ® 1.75

Pills Pale pink color, round, flat on both sides, with beveled edges, with one-sided risk.

Excipients:

Maninyl ® 3.5

Pills Rose color, round, flat on both sides, with beveled edges, with one-sided risk.

Excipients: Lactoses of monohydrate, starch potato, methylhydroxyethylcellulose, silicon dioxide precipitated, magnesium stearate, Krasnaya red A (E124 dye).

120 pcs. - Flakes of colorless glass (1) - packs cardboard.

Maninyl ® 5.

Pills Rose color, round, flat on both sides, with beveled edges and one-sided risk.

Excipients: Lactoses monohydrate, starch potato, magnesium stearate, talc, gelatin, punch dye (punching 4r).

120 pcs. - Flakes of colorless glass (1) - packs cardboard.

Clinical and Pharmacological Group

pharmachologic effect

Oral hypoglycemic drug from the group of sulfonylurea of \u200b\u200bthe II generations.

Stimulates the secretion of insulin by binding to specific receptors The β-cell membranes of the pancreas decreases the threshold of irritation of glucose β-cells of the pancreas, increases the insulin sensitivity and the degree of its binding with target cells, increases the release of insulin, enhances the effect of insulin to absorb glucose muscles and liver, thereby reduces glucose concentration in blood. Acts in the second stage of secretion of insulin. Lipolysis slows in adipose tissue. It has a hypolypidemic effect, reduces the thrombogenic properties of blood.

Maninyl ® 1.5 and maninyl ® 3.5 in micronized form is a high-tech, specially crushed shape of glibenklamide, allowing the drug to absorb from the gastrointestinal tract. Due to the earlier achievement of C Max of Glyibenklamide in plasma, the hypoglycemic effect practically corresponds to the rise in blood glucose concentration after meals, which makes the effect of the drug softer and physiological. The duration of the hypoglycemic action is 20-24 hours.

The hypoglycemic effect of the drug Maninyl ® 5 develops after 2 hours and lasts 12 hours.

Pharmacokinetics

Suction

After receiving inside the maninyl 1.75 and maninila 3.5, fast and almost complete absorption from the gastrointestinal tract are observed. The complete release of the micronionized active substance occurs within 5 minutes.

After receiving inside the maninyl 5, the absorption of the GTS is 48-84%. T MAX - 1-2 hours. Absolute bioavailability - 49-59%.

Distribution

The binding of plasma proteins is more than 98% for maninyl 1.75 and maninila 3.5, 95% - for maninyl 5.

Metabolism and elimination

It is almost completely metabolized in the liver with the formation of two inactive metabolites, one of which is excreted by the kidneys, and the other with bile.

T 1/2 for Maninyl 1.75 and Maninyl 3.5 is 1.5-3.5 hours, for Maninyl 5 - 3-16 hours.

Indications for the use of the drug

- type 2 diabetes (insulin-dependent) with the ineffectiveness of strict adherence of the diet, reduce body weight in obesity and sufficient physical activity.

Dosing mode

The dose of the drug the doctor establishes individually on the basis of the concentration of glucose in an empty stomach and 2 hours after meals.

The initial dose of the drug Maninyl ® 1.75 is 1/2-1 tab. 1 time / day. With insufficient effectiveness under the control of the doctor, the dose of the drug is gradually increased to achieve a daily dose required for stabilization. carbohydrate exchange. Average daily dose Makes up 2 tabs. (3.5 mg). Maximum daily dose - 3 tab. (In exceptional cases - 4 tab.).

If necessary, receiving higher doses are moving to the reception of the drug Maninyl ® 3.5.

The initial dose of the drug Maninyl ® 3.5 is 1/2-1 tab. 1 time / day. In case of insufficient effectiveness, the doctor's dose control is gradually increased to achieve a daily dose required to stabilize carbohydrate metabolism. The average daily dose is 3 tab. (10.5 mg). Maximum daily dose - 4 tab. (14 mg).

The drug should be taken before meat, not chewing and drinking with a small amount of fluid. Daily doses of the drug, constituting up to 2 tabs., Usually should be taken 1 time / day - in the morning, before breakfast. Higher doses are divided into Morning and Evening Reception. When you pass one drug intake, the next tablet should be taken at normal time, it is not allowed to make a higher dose.

The initial dose of the drug Maninyl ® 5 is 2.5 mg 1 time / day. With insufficient effectiveness, a dose of the drug is gradually increased by 2.5 mg / day with an interval of 3-5 days before reaching the daily dose required to stabilize carbohydrate metabolism. The daily dose is 2.5-15 mg.

Doses of more than 15 mg / day do not increase the severity of the hypoglycemic effect of the drug.

W. elderly patients There is a risk of developing hypoglycemia, therefore, for them, the initial dose should be 1 mg / day, and the supporting dose should be seamless under the control of the doctor.

Multiplicity of reception of the drug Maninyl ® 5 - 1-3 times / day. The drug should be taken 20-30 minutes before meals.

For transition from other hypoglycemic agents With a similar mechanism, the maninyl ® 5 is prescribed according to the scheme above, and the previous drug is canceled. When moving from the Biguanids, the initial daily dose is 2.5 mg, if necessary, the daily dose increases every 5-6 days by 2.5 mg before reaching compensation. In the absence of compensation within 4-6 weeks, it is necessary to solve the issue of conducting combination therapy with insulin.

Side effect

The most frequent undesirable action in the treatment of Maninyl ® drug is hypoglycemia. This condition can take a protracted nature and promote development. severe states (up to coma or ending with letters). With a sluggish process, diabetic polyneuropeathy or with concomitant treatment with sympatholic drugs, typical harbingers of hypoglycemia may be lowered or absent at all.

The causes of the development of hypoglycemia can be: an overdose of the drug, incorrect reading, irregular meal, elderly age Patients, vomiting, diarrhea, big physical exercise, diseases that reduce the need for insulin (violation of liver and kidney function, hypofunction of adrenal cortex, pituitary or thyroid gland), alcohol abuse, as well as interaction with other drugs.

Symptoms of hypoglycemia are a strong feeling of hunger, sudden abundant sweating, heartbeat, pallor of skin, paresthesia in the oral cavity, trembling, general anxiety, headache, pathological drowsiness, sleep disorders, feeling of fear, violation of coordination of movements, temporary neurological disorders (for example, vision disorders and speech, manifestations of paresses or paralysis or changed perception of sensations). In progression of hypoglycemia, a loss of sick-sick self-controlling and consciousness is possible. Often, such a patient marked wet cold leather and predisposition to cramps.

The following side effects are also possible.

From the digestive system:rarely - nausea, belching, vomiting, metal taste in the mouth, feeling of gravity and completeness in the stomach, abdominal pain and diarrhea; In some cases, a temporary increase in the activity of hepatic enzymes (GSH, GPT, SFF), medicinal hepatitis and jaundice.

Allergic reactions:rash, skin itch, urticaria, redness of the skin, swelling of quinics, point hemorrhages in the skin, peeling rash on large skin surfaces, increased photosensitization. Very rarely skin reactions can serve as the beginning of the development of severe conditions, accompanied by shortness of breath and decreased a blood pressure until the occurrence of a sick threatening life. There are separate cases of severe generalized allergic reactions with skin rash, pain in the joints, fever, the appearance of protein in the urine and jaundice.

From the side of the hematopoietic system:rarely - thrombocytopenia, erythroaction, leukocytopenia, agranulocytosis; In isolated cases - hemolytic anemia or Panciton.

Others:in isolated cases - weak diuretic effect, the temporary appearance of the protein in the urine, impairment of vision and accommodation, as well as the acute response of alcohol intolerance after its use, expressed by complications from blood circulation and respiration organs (vomiting, feeling the heat in the face and top of the body, tachycardia , dizziness, headache).

Contraindications for the use of the drug

- type 1 diabetes;

- diabetic ketoacidosis, diabetic prema and coma;

- condition after resection of the pancreas;

- severe liver function disorders;

- severe disorders of the kidney function (QC less than 30 ml / min);

- some acute states (for example, decompensation of carbohydrate exchange in infectious diseases, burns, injuries or after large surgical operations, when insulin therapy is shown);

- leukopenia;

- intestinal obstruction, stomach paresis;

- states accompanied by disruption of nutrition and the development of hypoglycemia;

- Pregnancy;

- Lactation period ( breastfeeding);

- known increased sensitivity to glibenklamide and / or other derivatives of sulfonylurea, sulfonyl amides, diuretic (diuretic) means containing a sulfonamide group in the molecule, and to a probenecide, so on. Cross reactions may occur.

FROM caution It should be prescribed a drug in feverish syndrome, diseases of the thyroid gland (with a function of the function), the hypofunction of the front proportion of the pituitary gland or the bark of adrenal glands, alcoholism, in the elderly patients due to the probability of the development of hypoglycemia.

Application of the drug during breastfeeding and breastfeeding

The drug is contraindicated to use during pregnancy and in the period of breastfeeding.

Application with violations of liver function

The drug is contraindicated in severe liver function disorders.

Application with violations of the kidney function

The drug is contraindicated in severe renal impairment (QC less than 30 ml / min).

special instructions

It is necessary to regularly control the concentration of glucose in the blood of an empty stomach and after meals.

Patients should be prevented about the increased risk of hypoglycemia in cases of receiving simultaneous ethanol (including the development of disulfira-like syndrome: abdominal pain, nausea, vomiting, headache) and in starvation.

The doctor must carefully consider the appointment of the drug Maninyl ® patients with a violation of the liver and kidney function, as well as during thyroid hypofunction, the front proportion of the pituitary gland or the adrenal cortex.

Correction of the dose of the drug Maninyl ® with physical and emotional overvoltage, changing the power mode.

Impact on the ability to driving vehicles and control mechanisms

In the period before the establishment of an optimal dose or when changing the drug, as well as with irregular reception of the drug Maninyl ®, it is possible to reduce the ability to driving a car or to control various mechanisms, as well as to occupations by other potentially hazardous species Activities requiring increased attention and speed of mental and motor reactions.

Overdose

Symptoms: Acute overdose of the drug Maninyl ®, as well as the long-term use of the drug in elevated doses, can cause severe, protracted hypoglycemia, in rare cases of the life-threatening life.

Treatment: Light states of hypoglycemia, namely, the first harbingers of it, the patient can eliminate himself, immediately eating a piece of sugar, jam, honey, drinking a glass of sweet tea or glucose solution. Therefore, the patient should always have several pieces of refinery sugar with him or confectionery (candy). Confectionery made specifically for patients diabetesIn such situations do not help. If the patient cannot immediately eliminate the symptoms of hypoglycemia, then he needs to immediately call a doctor. With a disorder of consciousness, a solution of dextrose was introduced into / m, 1-2 mg of glucagon. After the recovery of consciousness, the patient needs to give food rich in high-speed carbohydrates (in order to avoid re-development of hypoglycemia).

Medicinal interaction

Enhancing the hypoglycemic effect of the drug Maninyl ® should be expected in cases where treatment is carried out at the same time aPF inhibitors, anabolic agents, other oral hypoglycemic drugs (for example, acrolabe biguenides) and insulin, aeranopropazon, beta-adrenoblockers, quinine, quinolone derivatives, chloramphenicol, clofibrate, and its counterparts, derivatives of kumarin, dyspeciramide, pheniramine, phenyramidol, fluoxetine, MAO inhibitors, Mikonazole, Pask, Pentoxyphilline (in high doses of parenteral), permexylin, pyrazolone derivatives, phenylbutazones, phosphampamides (for example, cyclophosphamide, yiphosphamide, trophosfamide), samplezide, salicylate, sulfintizon, sulfinylaminamides, tetracycles, tricycal, during alcohol abuse.

Weching urine products (ammonium chloride, calcium chloride) enhance the effect of the drug Maninyl ® by reducing its dissociation and increase its reabsorption.

Along with the enhancement of the hypoglycemic action of beta-adrenobloclars, clonidine, guanethidine and reserpine, as well as drugs with the central mechanism of action can weaken the feeling of harbing hypoglycemia.

The hypoglycemic effect of the drug Maninyl ® can decrease with the simultaneous use of barbiturates, isoniazide, cyclosporine, diazoxide, GKS, glucagon, nicotine (in large doses), phenytoine, phenothiazines, rifampicin, saluretics, acetazolamide, sex hormones (for example, hormone-hormonal contraceptives), hormone preparations thyroid gland, sympathomometrics, indomethacin and lithium salts.

Chronic alcohol abuse and laxative means may aggravate the impaired carbohydrate exchange.

H 2-receptor antagonists can weaken on the one side, and on the other hand, the hypoglycemic effect of the drug Maninyl ®.

Pentamidine in isolated cases can cause a strong decrease or increase in blood glucose concentration.

With simultaneous use with the drug Maninyl ®, derivatives of the Cumarine derivatives may increase or weaken.

Drugs, inhibiting bone marrowing, increase the risk of myelosuppression while simultaneously use with the drug Maninyl ®.

The patient must be informed by the doctor about possible interaction.

Conditions of vacation from pharmacies

The drug is released by the prescription.

Terms and Storage Terms

List B. The drug should be stored in a place protected from light and inaccessible to children. Tablets 1.75 mg and 3.5 mg should be stored at a temperature not higher than 30 ° C, 5 mg tablets are not higher than 25 ° C. Shelf life - 3 years.

Full version of the instructions Viferon Gel

Instructions for the use of medicinal drug for medical use Viferon

Registration number: R №001142 / 02
Trade name of the drug: Viferon
MNN or grouping name: Interferon alpha-2b
Dosage form:gel for outdoor and local application.
Structure:

1 g of gel for outdoor and local application contains an active substance: Alpha-2B interferon Human recombinant 36 000 IU; Auxiliary substances: alpha tocopherol acetate - 0.055 g, methionine - 0.0012 g, benzoic acid - 0.00128 g, lemonic acid monohydrate - 0.001 g, sodium tetraborate decahydrate - 0.0018 g, sodium chloride - 0.004 g, albumin - 0.002 g, glycerin distilled (glycerol) - 0.02 g, sodium carmellosis - 0.02 g, ethanol 95% - 0.055 g, purified water - up to 1 g.

Description
Oporal gel-like weight of white with a grayish tint.

Pharmacotherapeutic group
Cytokine.

ATX code
L03AB05.

Pharmacological properties
Alpha-2B interferon Human recombinant has immunomodulatory, antiviral and antiproliferative properties. Suppresses the replication of RNA and DNA-containing viruses. The immunomodulating properties of interferon, such as the amplification of the phagocytic activity of macrophages, an increase in the specific cytotoxicity of lymphocytes to target cells cause its mediated antibacterial activity.

In the presence of an alpha tocopherol antioxidants of acetate, lemon and benzoic acids, the specific antiviral activity of the interferon increases, its immunomodulatory effect is enhanced, which allows to increase the effectiveness of its own immune response of the body on causative agents of infections.
The drug has a pronounced local immunomodulatory effect and contributes to an increase in the locally formed antibodies of the class of secretory IgAs, which prevent the fixation and reproduction of pathogenic microorganisms on the mucous membranes, which ensures the prophylactic effect of the drug for the prevention of viral and other diseases.

The gel base provides prolonged effect of the drug. Antioxidants included in the dosage form, - alpha-tocopherol acetate, lemon and benzoic acid - have anti-inflammatory, membrane-stabilizing, regenerating properties, and also contribute to the preservation of the biological activity of interferon alpha-2b of human recombinant.

Indications for use
- in the complex therapy of ARVI, including flu, frequent and long-term ARVI, including complicated bacterial infection;
- ORVI prevention, including influenza;
- in the complex therapy of the recurrent stenosis laryngotracheobronchitis;
- prevention of recurrent stenosing laryngotracheobronchitis;
- in complex therapy of acute and exacerbations of chronic recurrent herpetic infection of the skin and mucous membranes, including the urogenital form of herpetic infection;
- In the complex therapy of herpetic cervicitis.

Contraindications
Increased sensitivity to any of the components of the drug.

Application during pregnancy and in breastfeeding period
Pregnancy and breastfeeding period are not contraindicated for the use of the drug due to very low absorption of components. In the period of breastfeeding, do not apply to the area of \u200b\u200bnipples and the range.

Method of application and dose
The drug is used externally and locally.

In the complex therapy of ARVI, including influenza, long and frequent ARVI, including complicated bacterial infection

Recurrent stenosis laryngotracheobronhit

Acute and chronic recurrent herpetic infection
(when the first signs of the disease or during the harbingers)

Herpety cervicit

ORVI prevention, including flu

Prevention of recurrent stenosis laryngotracy

NOTE
On the mucous membrane of the nasal cavity gel is applied after cleansing the nasal passages, on the surface of the sky almonds - 30 minutes after the adoption of food. When applying the gel on the sky almonds, do not touch the almonds with a cotton swab, but only gel, the gel at the same time flows down on the surface of the almond. When applying a gel on the cervix, it should be previously removed with a cotton or gauze turbulence and selection from the vagina copies and cervix.
When applying the gel on the affected areas of the skin and mucous membranes in 30-40 minutes, a thin film is formed, to which the drug is again applied. If desired, the film can be peeling or washed with water before re-applying the drug.

Patients B. childhood Most often affected by influenza and colds. This is due to the fact that their immune system is not able to cope with malicious bacteria, which entails the occurrence of a dangerous pathological process in the body. A real assistant becomes a Gel Viferon for children, who, in case of a threat to health, should always be at hand at the caring and responsible parents. It helps to eliminate not only symptomatic manifestations Diseases, but also to overcome the main cause of pathology.

Advantages of the drug before analogues

Every year, the cold season requires particular attention to their health careful patients. Many famous drugs with Interferon repeatedly proved their increased efficiency and reliability, however, the medication has established itself as one of the most convenient drugs in relation to other similar complexes. The main advantages of the drug Viferon for children belongs:

• carrying out the increase in the action of interferon due to the presence of the auxiliary components;
• permissible to use patients under the age of year;
• the complex is perfectly combined with other drugs aimed at combating influenza and cold signs, as well as those that are accepted in the elimination of complications present (antibiotics);
• excellent means for comprehensive therapy;
• contributes to the compensation of low protection of the mucous child caused by certain physiological features patient.

The impact of the components of the composition is carried out after one hour. As a rule, visible positive results are not forced to wait long. In order to preserve the result, it is recommended to undergo a complete therapeutic course. Due to the gel base, it is possible to extend a favorable phenomenon. After applying the means, the formation of a film of a fine structure is detected, which is not necessarily subjected to elimination before applying. In case of detection of the lack of desired result, you need to report this to a specialist, as the child will need to replace therapeutic measures.

Very often, parents of small patients face a choice of ointments or gel. In this case, the benefits of use of each form of their drug. The main difference of medicines is a consistency. In ointments, it is characterized by a high thickness, which does not allow him to break through the surface. The ointment is most often used to combat papillomas or manifestations of viral infection on the skin, and it is allowed to use it only upon reaching the child of one year.

The complex has several analogues (according to the main active substance). The most popular of them includes Kipferon, Viborol, Genferon and Lacenobion. Used not only for treatment, but also as prophylaxis. This is especially true of breast-age patients, which are in early artificial feeding, children living within adverse environmental conditions, patients who were infected in the maternal womb. At the same time, the drug is permissible to use in old age and women in the period of having a child.

The composition of the drug

The antiviral activity of the gel Viferon for children is due to the presence in the preparation of the antioxidants of the alpha-tocopherol acetate, as well as lemon and benzoic acids. At the same time, the main immunomodulatory impact is carried out at the expense of these components, which entails an increase in performance immune system Child in relation to the causative agent of infection.

The presented antibodies of the class of secretory IgA contribute to the prevention of the delay in the body and the subsequent reproduction of malicious bacteria on the mucous membranes field. Due to this, a pronounced local immunomodulatory effect is achieved and the preventive possibility of a drug regarding diseases of viral and infectious ethiology is ensured.

The basis of the gel makes it possible to conduct a prolonged impact of the complex. Distinctive feature This form of release is due to the fact that the drug contains more additional components in its composition and the reduced presence of interferon. At the same time, the quality of suction increases, therefore, the complex of readings is significantly varied in a large direction.

Features of applications for the treatment of children

The drug in the form of gel is produced in an aluminum tube, which contains 12 grams medication. Viferon is a mass of opaque color (mostly white, but is not excluded gray) and a homogeneous structure. The main focus is an increase in the activity of the immune system and the struggle against diseases of viral etiology. Thanks to the components of the composition acting in the complex, an increase in the production of antibodies capable of stopping the reproduction of pathological pathogens is carried out.

Since the interferon substance is problematic absorbed into the upper layers of the epidermis, in which case the systemic effect on the body does not occur, limited by local boundaries of influence. The gel base contributes to the extension therapeutic effect. This is due to the occurrence of a thin film on the skin cover, while it is not necessary to eliminate it before submitting the use of the drug. The tool is allowed to apply with elevated patient's body temperature, this will help well cope with visible manifestations of symptomatic signs.

Features of using Viferon for the treatment of children are described in detail in the application instructions attached to the drug. Application funds are recommended using cotton sticks. This will make it possible to maximize contact with skin cover and reduce the possibility of getting another kind of infection. It is applied in a small amount of gel (long strip not more than 5 millimeters). In preventive purposes, the use of the drug up to three times a day is permissible, in the treatment of ARVI or other viral pathologies - the number of techniques increases to five. It is important to control that the time interval between the use of the complex was approximately the same.

Application of the gel Viferon on the mucous membrane of the cavity is carried out after cleansing the nasal passages. It is recommended to apply to palatal almonds after half an hour after receiving food. In the process of processing, it is necessary to carefully monitor so that the cotton swabs do not touch the almonds. This will allow uniformly distribute medicine, after which it starts to flock down the surface.

Gel Viferon is recommended to be stored in a dry cool room with an optimal air temperature within 2-8 degrees Celsius. It is important to ensure that the storage location is inaccessible to children of all age categories. The drug is allowed to use only within the expiration date. It is one year from the date of manufacture in the form of gel or ointment. The tube in the open state is allowed to store in a cool place no longer than two months. It is important to control the integrity of the packaging. In disruption of its safety, color or consistency can be changed medicinal preparation. This suggests that the gel is forbidden to use.

Contraindications

The tool is absolutely safe for use, since it does not contribute to the occurrence of addiction and manifestation of the body's allergic reaction. However, there are a number of factors that affect the prohibition of treatment with viriferon in the form of a gel for children. You are recommended to get acquainted with the contraindications before the use of the medicinal complex. Official instruction For use, includes the following conclusions:

• increased sensitivity of the patient's body to separate components of the composition;
• individual intolerance.

The period of having a child and breastfeeding is not considered to be banned regarding the use of Viferon. This is due to the reduced absorption of components.

Side effects

Despite the excellent tolerability of the drug, the complex still has a number of side effects. It belongs to them allergic reactioncapable of occupying in the form of rashes on the patient's skin, urticaria and hyperthermic manifestations. In some situations, the presence of a minor burning or dryness after applying the viriferon is permissible. Gradually, unpleasant and uncomfortable sensations are eliminated by an independent way.

Despite the effectiveness of Viferon for the treatment of children, it is not worth a hurry from the beginning of its use. It is recommended to carefully familiarize yourself with the instructions for use, which is in a cardboard box along with a tube tools. It contains basic requirements for applications. The complex can be easily purchased in the pharmacy paragraph without a doctor's prescription, but before buying it is still recommended to consult with a medical specialist.

Photo of drug

Description Actually by 14.10.2014

• Latin name:Viferon.
• ATH code:L03AB01
• Active substance:Human recombinant α - 2B interferon (Interferonum Alpha-2B, IFN-α2B).
• Manufacturer:LLC "FERON", Russia

Structure

In one gram mazi. Viferon for local and outdoor use contains 40000m Interferonum alpha-2b as active component, as well as 0.002 grams (Alfa-Tocopherol Acetate) and a number of other auxiliary ingredients.

In one rectal suppository contains 150,000 me Interferonum alpha-2b alpha tocopherol acetate (ALFA-TOCOPHEROL ACETATE), 0.015 g

In one rectal Suppository Viferon-2 contains 500,000 me Interferonum alpha-2b as an active ingredient, 0.055 g alpha tocopherol acetate ascorbic acid (ACIDUM Ascorbinicum) and a number of other auxiliary ingredients.

In one rectal Suppository Viferon-3 It contains 10,000,000 ITERFERONUM ALPHA-2B as an active component, 0.055 g alpha tocopherol acetate (ALFA-TOCOPHEROL ACETATE), 0.022 ascorbic acid (ACIDUM Ascorbinicum) and a number of other auxiliary ingredients.

Part Candles Viferon-4 It includes 30,000,000 me Interferonum alpha-2b as an active ingredient, 0.055 g alpha tocopherol acetate (ALFA-TOCOPHEROL ACETATE), 0.022 g ascorbic acid (ACIDUM Ascorbinicum) and a number of other auxiliary ingredients.

In one gram gel Viferon For local and outdoor use contains 36000m Interferonum alpha-2b As an active ingredient, as well as 0.055 gram of alpha tocopherol acetate (ALFA-TOCOPHEROL ACETATE) and a number of other auxiliary ingredients.

Form release

The drug has three medicinal forms:

• candles Viferon 150 thousand, 500 thousand, 1 million and 3 million me;
• ointment;
• gel.

Viferon Gel is an opaque homogeneous substance of a grayish white color.

Ointment is a viscous homogeneous mass with a characteristic Lanolin smell. The ointment color can vary from yellowish white to yellow.

Suppositories Viferon have a bullet form, their consistency is homogeneous, and a white color with a yellowish tint. Inhomogeneity is allowed in places of cut. There may be a recess in the form of a funnel.

pharmachologic effect

The drug is pronounced antoviral , antiproliferative and immunomdular act.

Thanks to this combination of components, it is also possible to eliminate the likelihood of development in a patient. adverse Reactionswhich occur with the introduction of interferon preparations parenterally, and normalize the functioning of the endogenous (internal) interferon system.

Application of Viferon for Treatment and Prevention viral infections Allows you to reduce the doses of the prescribed patient hormonal drugs And (in some cases, it is generally possible to avoid the appointment of these drugs).

In addition, the use of the drug allows to reduce the severity of toxic effects antibacterial or hormone therapy .

The fact that the neutralizing antibodies to the patient's neutralizing antibodies in the patient is not formed even long use Viferon.

Pharmacodynamics and pharmacokinetics

Alpha interferon belongs to the group water soluble proteins . The mechanism of its action includes:

• direct antiviral action (It is effective in relation to viruses , causing, hepatitis etc.);
• antibacterial (bacteriostatic) action against mixed type infections;
• recovering function endogenous (internal) system interferon;
• stimulating factors that improve the production of antibodies ;
• increasing the degree of sustainability of the body to various kinds of infections.

Antibacterial activity of matter determined by its ability to raise citotoxic activity of lymphocytic cells and stimulate phagocytic activity of macrophadges .

Antiproliferative action IFN-α2B has in the involvement of both cell cultures and man xenotranspplants And in laboratory animals.

IFN-α2B suppresses replication genome Virus . Binding to specific receptors on membranes cells Alpha interferon initiates a certain sequence of complex reactions inside the cell and including the induction of some.

Developing against the background of the use of Viferon membranestabilizing , regenerating and anti-inflammatory effects due to the activity of those who are part of the drug substances possessing powerful antioxidant action - alpha tocopherol acetate and.

After parenteral administration of the drug, the interferon alpha concentration indicator in the patient reaches maximum values \u200b\u200bfor 3-12 hours.

When using IFN-α2B vaginally or rectally, the substance is absorbed through mucoset0y shell , penetrates the adjacent fabrics and lymphatic system , thereby providing a systematic action. And due to its ability to partially fix on cells of the mucous membrane IFN-α2B acts locally.

Using rectal suppositories Viferon increases interferon circulation time in blood system (With the introduction of IFN-α2B drugs into the muscle or in Vienna, this pharmacokinetic indicator is substantially less).

The level of serum interferon is reduced in approximately twelve hours after receiving Viferon, which implies the need for its re-administration.

Derived from the body interferon alpha mainly through renal catabolic . Metabolization in the liver and excretion with biliary - Less significant ways to eliminate. Partly interferon alpha eliminated through kidney unchanged.

The substance is not cumulating (not accumulating) in various tissues of the body.

Indications for the use of Viferon: from what candles, ointment and gel

Indications for the use of gel and ointment

Gel is shown for the treatment and prevention in children Orz (including ChBD) and recurrent false Crup (writing laryngotracheobronchita ).

Ointment recommended for treatment lesions of the skin and mucous membranes provoked different viruses (in particular, for the treatment of lesions caused by human activity and activity Virionov belonging to the family herpessvirus ).

In combination with other therapeutic measures, the formulation in the form of ointments is allowed to use for treatment respiratory diseases In children older than one year old age.

Indications for the use of candles, for which this dosage form is prescribed

Viferon in the form of suppositories is prescribed as one of the components of complex therapy:

• for treating children infectious and inflammatory diseases (The drug is allowed for use including newborns and in premature babies, the period of gestation is more than 34 weeks).
• viral hepatitis, and D in adults and children (as a rule, the drug is used in combination with plasmocytophoresis ).
• With chronic form hepatitis viral etiology complicated.
• Pregnant women who were diagnosed urogenital infections as well as in pregnant women herpetic infection of mucous and skin infection .
• When Orz and in adults (including including ORVI complicated by bacterial infection ).

Before applying Viferon, consultation is required by the attending physician.

Contraindications

Viferon is contraindicated to prescribe to patients with hypersensitivity To the interferon alpha or any of the members of the auxiliary substances.

Side effects

Against the background of treatment with viriferon in the form of rectal suppositories, gel or ointment in individual patients with hypersensitivity to its components, side effects, expressed in the form of various kinds, may occur.

Side effects We are reversible, do not require the appointment of specific treatment and disappear independently within 72 hours after the cancellation of the drug.

Instructions for the use of Viferon

Ointment Viferon: Instructions for use

In this dosage form, the drug is used as a local and outdoor.

A small amount of ointments are distributed by a thin layer on the affected areas of the skin and mucous membranes from three to four times a day, and then neatly rubbing. The course of treatment lasts, as a rule, no more than a week.

Gel Viferon: Instructions for use

Gel is designed for local applications. It is also allowed to use it in combination with other drugs.

Gel is used for prevention in children acute respiratory diseases and recurrent syndrome Crup (singing Larygita ). Applying a Tampon, they are treated three times a day for three months almonds Child.

Courses should be repeated twice a year.

The use of gel for infants in prophylactic purposes allows to reduce the likelihood of a child ARVI What is especially relevant during epidemics. To do this, a small amount of gel is applied to pre-dried mucous nasal cavity .

IN therapeutic purposes almonds Treat up to five times a day until the acute phase of the disease is over. Further treatment implies the applying of the drug three times a day for three weeks.

Gel is also used to treat adult patients chronic infection caused by herpess . Therapy with different localization of the pathological process is recommended to begin as early as possible.

Optimally - as long as the disease flows in latent form (in a hidden form for clinical recognition) and makes itself felt by the episodic appearances of the harbingers.

The lesion is needed to process from four to seven times a day. The duration of treatment is from three to five days. If necessary, a re-course can be assigned.

Candles Viferon: instructions for use

Suppositories are used rectally in combination with other drugs appointed with a specific disease in the form of tablets, powders or injection.

For adult patients with chronic, as a rule, assign , the dose of the active substance in which is 30,000,000 meters. Treatment involves the introduction of suppositories one by one twice a day for ten days.

In the future, they are enough to be brought three times a week. The course of treatment varies depending on the nature of the flow and the severity of the disease and is from six months to a year.

With the defeat of the body urogenital infections , and pregnant women also have primary and recurrent herpetic infection For treatment, visifer-2 candles with an active substance content of 500,000 meters are recommended.

Suppositories are administered one twice a day. The duration of the course varies from five to ten days. If necessary, it is repeated.

For the treatment of infection caused by herpessurus , shown in which the dose of the active substance is 10,000,000 meters. Candles are administered one twice a day, withstanding the twelve-hour intervals between the introductions.

The duration of the course is 10 days. In the event of a relapse, the duration of therapy determines the attending physician (optimal is considered to begin treatment at the very beginning of the manifestation of its first signs).

For the treatment of ORZ and influenza for adult candles, 500 thousand meters are prescribed in the dosage. They are put on one twice a day, withstanding equal intervals between the introduction.

Instructions for applying candles for children

For the treatment of newborn and premature babies, the period of gestation is more than 34 weeks in combination with specific therapy appointed with a specific infectious diseaseIt is recommended to use Suppositories Viferon 150 000 IU.

The course involves the introduction for five days of one suppository twice a day at equal intervals of time.

Premature babies, whose gestational age is less than 34 weeks, are prescribed to put on the prostration of five days by one Suppository Viferon 150,000 IU three times a day.

Children, including newborns and premature babies, influenza , ARVI , patient spend one or two course of therapy; For the treatment of infection provoked herpes virus usually require two courses; for cytomegalovirus infection , infections caused by mycoplasmas and mushrooms of the genus Candida as well as sepsis It is necessary to conduct two or three courses.

There are five-day intervals between courses.

• babies up to 6 months - from 300 to 500 thousand meters per day;
• babies from 6 to 12 months to 1 year - 500 thousand meters per day.

Children older than one year old age are prescribed 300 thousand meters per quarter. M of the body surface of the body per day, and the children older than a seven age - 500 meters.

The calculation of the optimal children's therapeutic dose is made on the basis of data on the severity and nature of the course of the child.

Daily dose must be divided into two receptions, withsting equal time intervals between them. During the first ten days, treatment implies the daily administration of suppositories, then the candles put three times a week. The duration of the course is from six months to one year.

Children who are diagnosed chronic form hepatitis A With a pronounced degree of activity and the presence of suppositories should be administered one by one twice a day for two weeks before the procedure plasmocytophoresis or hemosorption .

Children younger than a seven age showing a dosage of 150 thousand meters, children over seven years old - a dosage of 500 thousand meters.

How to put candles baby?

Before the introduction of suppository baby Put on the side on the loaf, pressing his legs to the stomach. It is best to put candles after the intestinal emptying.

To facilitate the introduction of children's candles, Viferon can be cut in pressure and / or drop a little children's cream or vaseline oil on it.

Then you need to push the baby's buttocks with your fingers, put a candle and clamp the buttocks for a while, fixing the child.

Overdose

There were no cases of overdose.

Interaction

Interactions in dosage forms for local and outdoor use are not detected.

Viferon in the form of rectal suppositories is well combined with all drugs that are used to treat the diseases described in the section "Indications for use".

The drug is compatible with antibacterial and hormonal drugs , treatments for chemotherapy as well as with immunosuppressors .

Terms of sale

Viferon in the form of suppositories, gel and ointment is released in pharmacies without a doctor's prescription.

Storage conditions

Optimal temperature mode For the storage of the drug - from 2 to 8 degrees Celsius. Store the drug in all its dosage forms is recommended in a dry, protected from light and hard to reach for children.

Shelf life

For rectal suppositories - 24 months.

For gel and ointment - 12 months.

special instructions

Many are interested in whether there are injections, drops or pills Viferon. The answer to this question is negative.

It is explained by the fact that protein molecules Finding B. digestive tract exposed to the effects of various secretor fluids And, and since active substance Viferon IFN-α2B is belkom. , then these enzymes There will be a similar action on it.

Thus, the reception of interferon alpha in the form of tablets will not give the expected therapeutic effect and will simply be inappropriate.

As for injections, Viferon B / B is not introduced, since in this dosage form interferon is able to provoke serious adverse reactions from various organs and systems of organs.

Working out the drug Viferon, the specialists of the company "Feron" the main task was set safe money For treatment viral infections In all groups of patients, including newborns (including premature) and pregnant women.

Therefore, to search in pharmacies Viferon in tablets or injections is a waste of time.

Often, patients have questions "What is the difference between Viferon and Viferon-2?" Or "What are the differences in Viferon and Viferon-3?".

Candles Viferon is available in four versions, which, accordingly, are called Viferon-1, 2, 3 and 4. They differ from each other in their composition of the IFN-α2B.

Viferon-1 is used to treat children up to seven years and Pregnant women, Viferon-2 - for children over seven years old and treatment of viral infections Pregnant women, Viferon 3 is used to treat adult patients, as well as viral hepatitis In children, Viferon-4 is prescribed only adults.

In the network, it is often possible to find applications that Viferon, like other interferon preparations, causes cancer . However, they do not have confirmation. It is known that injection forms Interferon provoke the development of a large number of adverse reactions. Unlike them, the virifer is produced in the form of candles, ointments and gel, therefore interferon is absorbed into its composition in from mucous membranes and skin in very small quantities.

Analogs of Viferon

When prescribed by a doctor of a drug (and especially if the drug is expensive, like, in particular, Viferon), most patients begin to search, which can be replaced with this tool and find analogs cheaper.

Analogs of candles Viferon is drugs Vitaferon . Prices for analogues in Ukrainian pharmacies begin with 46 UAH.

It is also not necessary questions "What is better - or Viferon?", "What is better - or Viferon?" or " Or Viferon - what is better? ".

Trying to figure out what the difference between these drugs can be concluded that they all have a similar pharmachologic effect. Honors from Anatheron is that the latter is homeopathic and produced in the form of sublingual tablets.

Kipferon produced in the form of suppositories for rectal and intravaginal use. As for, it is produced in the form of droplets and spray for intranasal use.

The decision on which of the listed drugs should be appointed in a particular case, the doctor takes.

Viferon for children

Instructions for children on candles Viferon resolves the use of all drug forms of the drug in pediatrics. At the same time, ointment, gel and candles Viferon for children allowing to assign from birth.

For treatment I. prevention of viral infections Children are prescribed Viferon-1 and Viferon-2 candles, the dosage of the active substance in which, respectively, is 150,000 and 500,000 meters.

Candles for children of 150,000 and 500,000 meters can be assigned in combination with antibacterial drugs (for example, when, especially when the disease occurs in severe form and is accompanied by pronounced symptoms organism and secondary pyodermia ).

Application Viferon B. etiotropic therapy In combination with drops, childcare candles, tablets or injections reduces the virus load on the child's body, stop virushemia , as well as reduce the risk of developing various sorts of complications and adverse reactions.

Studies have shown that intranasal application In the preventive objectives of ointments for newborns and children younger age Allows you to prepare a child to a preschool institution. All children belonged to a group of frequently ill, however, after the receipt in kindergarten, 41% of them did not get sick in the first three and a half months.

Candle reviews Viferon for children suggest that over time, against the background of viriferonoresabilities, all children from the control group showed a decrease in morbidity.

How often can you put candles to children?

In accordance with the standard sharp treatment scheme respiratory viral diseases Viferon is prescribed as part of comprehensive therapy. The course of its use is from five to ten days.

As a rule, the patient requires one or two courses every six months or a year. However, on the recommendation of the doctor is allowed and more frequent repetition.

When using the drug addiction to stimulation of endogenous interferon does not develop.

Viferon during pregnancy

Ointment and gel Viferon is characterized by low systemic adsorption, so both of these dosage forms are allowed to use pregnant women (on any gestation period) and nursing women.

Apply candles Viferon for pregnant women It is allowed from a 14-tender term. But when candles can be used without any restrictions.

Assigned to Pregnancy Candles of Viferon-2 with a dosage of 500 thousand meters. They are recommended to be administered one twice a day at equal periods of time daily for ten days. Over the next ten days, it is enough to enter twice a week for one suppository twice a day.

Four weeks later, it is necessary to conduct a preventive course.

For prophylaxis for candles, the virifer is prescribed in the dosage of 150 thousand meters. They introduce them one twice a day for five days. FROM preventive goal Courses are repeated every four weeks until the birth of a child.

In general, women are advised to heal gynecological infections Even during the planning of the child, before the occurrence of pregnancy. With the goal, as a rule, vaginal candles are used Genferon .