Interferon is an immunomodulatory, antiviral, antiproliferative and antitumor drug.

The antiviral mechanism of the interferon action is based on the obstacle to the virus infection of cells, the change in the properties of the cell membrane, braking or preventing the adhesion and the penetration of the virus inside the cell, as well as the initialization of the synthesis of several specific enzymes and the synthesis of protein proteins and the virus RNA in the cell. By providing a modulating effect on the synthesis of some oncogens, which leads to inhibition of tumor growth and normalization of neoplastic cell transformation and changes the cytological framework and metabolism of the cell membrane, preventing the growth and development of tumor cells - it has an antiproliferative and antitumor effect. And stimulating the antigen recognition process by immunocompetent cells and modulating the activity of lymphocyte-killers participating in antiviral immunite, interferon has its immunomodulatory effect.

In order to prevent any respiratory viral infections, the interferon is prescribed in the case of a possible threat of infection (in the presence of a viral disease in family members, in the team) and its reception continues until the preservation of the danger of the development of the disease (especially in children).

FROM therapeutic goal This drug is used when manifesting the first symptoms. viral infection - cold, sneezing, easy nose congestion, stringing. This drug is effective tool For the treatment of ARVI, which are accompanied by a runny nose at any stage of the disease, and is used intranasally in the form of inhalation and / or injection of the nose.

Interferon action mechanism

In general, the concept of "interferon" is currently united by a certain amount of proteins with similar properties that are allocated by the cells of the body in response to the introduction of a virus or other alien agent, interferons activate the immune response, and the cells of the body become immune with respect to viruses. These specific proteins were opened in 1957 by chance during the experiments by the employees of the London National Institute Virutic British Aizek and Swiss Lindeman.

The biological and tissue activity of interferon appears as a result of binding to specific receptorslocated on the surface of the cell membranes and then there is an inhibition of the virus replication in an already infected cell, the braking of cell proliferation, an increase in the phagocytic activity of macrophages and enhancing the specific toxicity of lymphocyte-killers to target cells.

By its biological nature, interferons refer to tissue hormones that are characterized by a versatile directional action: the ability to induce the immunity of cells to a large range of viruses, to slow down the cell division, change the surface properties of tumor cells and cell phenotype, the basis for activating the transformation, which leads to a decrease in the oncogenicity of malignant cells. Also interferons establish the relationship of cells among themselves, as well as with lymphocinas, antibodies, hormones, cytokines and growth factors.
The use of interferones as drugs is based mainly on the three general properties of this group: immunomodulating, antiproliferative and antivirus.
The biological efficacy of interferon was determined by the scope of its clinical use - hazardous viral infections and proliferative processes in oncology and neurology: to stabilize and repair cell genome, preventing phenotypes of tumor cells and braking of the formation of high-resistant clones and resistant to medicines of tumor cell populations. And also for the prevention of metastatic processes and activation of natural killers: macrophages - the main cells of non-specific antitumor supervision.
But the effect of interferon action depends on functional state Activated systems: the presence of receptors to interferon on the cell surface (tumor and / or immune), the level of production of intracellular substances that implement the interferon-induced chain of reactions. As well as the optimization of therapeutic schemes: the duration of interferonotherapy, the selection of doses, the route of administration, and the combination with the preparations of other groups.

Clinical researches

The adverse reactions and therapeutic and prophylactic effect of recombinant and leukocyte α-interferon were significantly understood, during the many years of experience of the clinical use of these drugs during various diseases:
acute and chronic viral hepatitis, herpetic diseases of the eyes, leather and genitalia, acute viral-bacterial and viral meningoencephalitis, chronic septic diseases, ORVI, paragripping and coronavirus infections, multiple sclerosis, hemoblastosis, breast cancer, kidneys, melanoma, malignant ovarian neoplasms and bladder, lymphosarcoma and lymphoblastic leukemia.
It has been proven that with severe proliferative processes and viral infections, it is necessary to use interferon in the form of intravenous injections, local applications, subdural or intracectal administrations.

The drug is intended for the prevention and treatment of influenza, as well as other respiratory viral infections - hepatitis B and active hepatitis C, herpetic infection, pointed circularity, multiple sclerosis. The interferon is also widely used in the fight against various neoplasms of the lymphatic and blood formation system: with chronic myelolomicosis, myeloma disease, high-meal leukemia, thrombocytosis (primary and secondary) and sarcoma caps.

Currently, interferon alpha-2b human recombinant, interferon leukocytarium human liquid, interferon human leukocyte in candles, interferon leukocytic human dry, interferon alpha-2 recombinant ointment on a hydrogel basis.

Alpha Interferon (Interferon Alpha)

This drug interferon group is a combination of various subtypes

natural α-interferon produced from human blood leukocytes.

Interferon applies: parenterally - intramuscularly and subcutaneously, intranasally, and the dose, the duration of use and the frequency of administrations are determined depending on the severity of the disease, indications, the method of administration and the individual reaction of the patient. An exemplary diagram of administration in high-melling leukemia: the initial dose is 3 million meters per day with a course of treatment from 16 to 24 weeks, followed by a transition to supporting treatment at a dose of 3 millionth three times a week. In the treatment of chronic active hepatitis B: the initial dose - 4.5 million II three times a week for six months, with chronic hepatitis C: the initial dose is 6 million months three times a week for three months with the transition to a supporting dose of three million I could three times a week for three months. In the primary and secondary thrombocytosis, in the transitional phase of chronic granulocyte leukemia and myelofibrosis, with multiple myeloma, special treatment schemes are prescribed by interferon in combination with corticosteroids and cytostatics different duration and dosages.

Interferon drops

This drug is a lyophilic dried powder in ampoules of 1000 meters of antiviral activity in each, respectively, marking.

The intranasal interferon is prescribed for the treatment and prevention of influenza and other ARVI (paragripping, adenoviral, rhinosincithic and rinovirus infection).

In order to prevent interferon applied only in the event of a direct threat of infection and continues until the preservation of the risk of developing the disease (especially in children of the first year of life).

With therapeutic goal, this drug is used in the manifestation of the first symptoms of the beginning of a viral infection - a cold, easy nasal congestion, sneezing, stripping, as well as a violation of general well-being.

Interferon is prescribed locally, by spraying or instillation into nasal moves.

Immediately before use, the dry contents of the ampoule are dissolved with warm boiled water or saline to the label on the ampoule. The ampoule shakes until the contents are completely dissolved. It must be remembered that the effectiveness of this drug Directly depends on the correctness of its use - the finished solution can only be used during the day, then prepare new, due to the innaactment of the drug.

For the prevention of viral infections (possibly use in early childhood) In each nasal course, five drops (0.25 milliliters) of the interferon solution with an interval of at least six hours are introduced.

With therapeutic purpose, the interferon is prescribed five drops (0.25 milliliters of the solution) to each nasal stroke with an interval one or two hours at least five to six times a day for three to five days.

In modern pediatrics, special attention is paid to prevention viral diseases. And one of the most effective preventive drugs in the assortment of modern pharmacology is considered to be interferon or its analogues. It was this drug that found its widespread use in the prevention of sharp respiratory viral diseases in children and in their treatment at the initial stage clinical manifestations: Rudny, easy nose, sneezing, shaking. To help this pharmaceutical preparation You can resort to any of the stages of the infectious process and the effectiveness of its use to combat infection, both at the initial stage of its development and in full swing is the same. But the ability to prevent the development of the infectious process, if the kid is only a runny nose in the form of monotherapy with a conventional leukocyte interferon: five drops of solution to drip into each nasal passage at least five times a day. The course of treatment is three to five days. And for the greatest effect in a shorter period of time, inhalation with interferon is effective. For such inhalation, three ampoules of interferon and ten milliliters of water with a temperature of no more than thirty seven degrees are needed. Inhalation is carried out both through the nose or through the mouth of the child, but no more than two times a day.

Also, the interferon solution is widely used in the fight against viral inflammatory eye diseases in ophthalmology - the solution of interferon is buried directly after consulting an ophthalmologist.

In premature, weakened children or kids who have congenital pathology or perinatal pathology for the treatment of viral infections, an analogue of the drug Interferon is used - Viferon.

Contraindications for the appointment of interferon

Confirmed increased individual sensitivity to alpha interferon, hypersensitivity to chicken protein or history of history, heavy organic diseases cardiovascular system, violation of the functions of the central nervous system and / or epilepsy, pronounced disorders of kidney or liver functions, disease thyroid glandStandard to standard therapy. As well as cirrhosis of the liver if there are symptoms of liver failure and / or chronic hepatitis In patients who recently received or receiving treatment with immunosuppressants and autoimmune hepatitis.

Interferon Alpha is prescribed with caution in combination with sedatives, sleeping pills and opioid analgesics.

Application of interferon during lactation and pregnancy

Nazoneks - All about the preparation

In this article we will talk about one of the effective antiviral and immunostimulating drugs. It will be about human leukocyte interferon. We will analyze the properties of the drug, testimony to its purpose, instruction manual and so on.

Characteristic of the drug

Leiccitarian human interferon ( international name - Interferon alpha) is available in two forms - a solution for inhalation and intranasal use and dry lyophilized powder (sometimes compressed in tablets). The liquid form has a shade from colorless to light pink, dry - from white to pinkish.

Interferon Leukocytary Human (Interferon Leukocytic Human) is a protein complex, which synthesize the leukocytes of donor blood under the influence of the interferon inductor. Purify the ultra-and microfiltration method.

Analogs of this immunomodulatory drug:

• "Lokferon".
• "Inferon"
• "No-Feferon" and others.

The tool can be used in a complex with other drugs. The drug is released without a doctor's prescription, is suitable for 2 years from the date of manufacture. It is necessary to store it in protected from light, cool (2-8 degrees above zero) place. Bear from children!

The average prices for human leukocytar interferon are relatively low. So, in most pharmacies, a pack with 10 ampoules of the drug will cost 80-120 rubles.

The composition of the drug

In 1 ml of liquid human leukocyte interferon Contains:

• Interferon alpha - 1000 IU.
• Sodium chloride - 0.09 mg.
• Sodium dihydrophosphate dihydrate - 0.06 mg.
• Sodium hydrophosphate dodechydrate - 0.003 mg.
• Distilled water for injection - about 1 ml.

Pharmacological properties

This immunomodulatory drug refers to pharmacological group cytokines. Its properties are allocated as follows:

• Immunostimulation - makes a stronger immune response.
• Immunomodulation - normalizes immune status.
• Antibacterial impact - struggle against of different types mixed infections.
• Antiviral action - helps the body to resist such diseases as herpes, influenza, adenoviral diseases.
• Anti-inflammatory, antitumor effect.

Dry and liquid means is not toxic, sterile, harmless when administered by respiratory tract. In this case, use the injection powder is prohibited.

Indications for use

Human leukocytar interferon is used both for the prevention of acute viral infections and for the treatment of early forms of diseases with initial symptoms.

Indications can be divided into three main groups:

• Intranasal application: preventive measures and treatment of ARVI, influenza.
• Parenteral Application: Pointed Condyloma, Hepatitis B and C, Non-Hodgkin Lymphoma, Malignant Melanoma, Multiple Mieloma, Renal Carcinoma, Capo Sarcoma in AIDS suffering from AIDS (do not get at this time acute infections), high-timer leukemia, mushroom micaosis.
• Rectal application: therapy of chronic and acute viral hepatitis.

Also, the drug will be effective at:

• chronic myelolekosis;
• primary and secondary thrombocytosis;
• transition stage of chronic granulocyte leukemia, myelofibrosis;
• reticulosarcom;
• scarmed sclerosis.

Contraindications

Instructions for the use of interferon of human leukocyte indicates the following contraindications to the use of the drug:

• Epilepsy.
• Violation of the Functions of the CNS.
• Violation of kidney and liver functions, a hematopoietic system.
• Organic heart disease.
• Chronic hepatitis in persons whose recent treatment consisted of immunosuppressants.
• Diseases of the thyroid gland.
• Chronic hepatitis.
• Cirrhosis liver with signs of hepatic insufficiency.
• Pregnancy and lactation period.
• Allergy.
• Increased individual sensitivity to active component - Interferon Alpha, as well as to all drugs of protein origin, chicken meat and eggs.

The drug is dangerous to accept and in the following cases:

• Expired expiration.
• Violated the integrity of the packaging.
• There is no marking on the package.

Dosage and application

Instructions for the use of interferon leukocyte human prescribes:

• Children up to 3 years to enter the drug only intranasally (spraying, instillation).
• Children since 3 years old, adults are additionally allowed inhalation.

Intranasal application. Ampoule with medicine opens immediately before use. Then, chilled boiled or sterile distilled water is added to it strictly to line with 2 ml on the capsule. The remedy is carefully shaken until complete dissolution.

The drug is buried in the nose with a syringe without a needle or medical pipette. Another way is spraying: you can use both a sprayer of a third-party company and the one that comes complete with the preparation. The nozzle is dressed on a syringe without a needle, then it is applied close to the nasal passage or entering it about 0.5 cm. Spraying occurs by pressing the piston of the syringe. In this case, the patient should sit, throwing the head up.

Dosage of the drug:

• Prevention: Applied throughout the danger of infection. Installing - 5 drops, spraying - 0.25 ml in each nasal passage. On a day, manipulation is carried out up to 2 times with an interval of at least 6 hours.
• Treatment: When manifesting the first signs of the disease. 5 drops or 0.25 mg per each nostril. The procedure is repeated up to 5 times a day with an interval of 1-2 hours.

Interferon Human leukocytic children and adults are introduced in equal doses.

Inhalation. Inhalation is considered more efficient. For it, you need to purchase an inhaler of any manufacturer. For one procedure, the contents of three capsules are required, which should be dissolved in 10 ml of water, heated to 37 degrees. This method is introduced through the mouth and the nose twice a day for 2-3 days.

Enter the injection tool!

Side effects

When applying this immunomodulatory drug, the following are possible. side effects:

• From the head of the gastrointestinal tract: change in taste sensations, dry mouth, flatulence, constipation, vomiting, diarrhea, nausea, loss of appetite. In rare cases - disruption of the liver.
• From the CNS side: Ataxia, drowsiness or sleep disorder, violation of consciousness, depression, nervousness.
• From the heart and blood vessels: arrhythmia, arterial hypotension.
• Dermatological consequences: a rash on the skin, a slight alopecia, erythema, dry skin.
• Influencing syndrome: weakness, fever, Malgy, headache.
• Other: granulocyptopenia, feeling of weakness, lethargy, loss of body weight, vision disorder, dizziness.

special instructions

With caution apply the tool stands at:

• Recently suffered myocardial infarction.
• Mielodepresses, changing blood clotting.
• Elderly patients who, when using high doses of the drug, the side effects from the CNS were diagnosed. Perhaps it is worth even interrupt treatment.
• Patients with hepatitis C Before treatment, it is necessary to conduct a survey at the level of TSH in the blood. Only as normal indicators You can begin therapy by interferon. In other cases, there is a violation of the functions of the thyroid.
• Combination with opioid analgesics, sleeping pills, sedatives.

Interferon leukocytarny human is an effective immunostimulating anti-infectious agent. It has a number of features of application and contraindications, so before applying it is necessary to familiarize with the instructions.

The interferon drug consists of a mixture of natural alpha interferons, which are obtained from human blood leukocytes. He found its use in various directions of medicine for the treatment and prevention of immunodeficiency states and viral diseases, as it has immunostimulating and antiviral qualities. And an adult, and a child can use this medicinal product. Consider in more detail what is interferon, instructions for use, the price of this drug.

Composition, release form and pharmacological properties

Interferon is produced in the form of a lyophysiat, from which the solution is subsequently prepared. In the cardboard pack of the drug are ampoules 5 or 10 pieces volume of 2 ml, each of which contains 1000 leukocyte interferon of a person. This is a white powder, easily decaying when shaking or pressing. The drug contains detailed instructions for use. In addition, the interferon is produced in the form of suppositories, which are used for rectal administration and in the form of tablets.

It is obtained by a means of leukocytes of human blood, so that a pronounced immunostimulating and antiviral influence turns on the body. Under the influence of interferon, the resistance of the human body to infections and viruses increases.

Indications

Instructions for use indicate that recombinant human interferon can be used both adults and children for the treatment of the following states:

Contraindications

As indicated in the instructions for use, the drug is prohibited by patients if they have the following diseases and conditions:

• disorders of the kidney and liver;
• severe heart disease;
• cirrhosis of the liver;
• diseases of Central nervous systemss;
• intestinal bleeding;
• individual intolerance;
• premature children;
• heavy thyroid diseases.

With extreme caution, the drug should be used during pregnancy and lactation.

Mode of application

Interferon in ampoules is used if the threat of infection with the virus has arisen. Daily dose funds And only a doctor should determine the duration of treatment, which takes into account the clinical symptoms of the pathological process, the individual characteristics of the patient's body and its age.

The contents of the ampoule are dissolved in 2 ml of physiological sodium chloride or water for injection. To avoid virus infections or the flu in the autumn-spring period, the doctor recommends the patient to dig a drug 2 drops into each nasal passage 4 - 5 times a day during the week. Rectal suppositories are prescribed for the treatment of diseases that are caused by the papilloma or herpes virus.

If the patient passes a course of radiation irradiation or chemotherapy in the treatment of an oncological disease, then interferon is introduced intramuscularly. Therapy with this drug should be started a week before irradiation, and after the end of the course, treatment is continued for two weeks. It helps the patient easier to transfer irradiation and chemotherapy, and also reduces the severity of side effects.

Side effects

Interferon is usually very well tolerated by people. If a person has an increased individual sensitivity to the drug, the following side effects may develop:

• hardwriter, allergic rash on the skin;
• malgy, lubrication in body, weakness, dizziness, body temperature, back pain, headache;
• violation heart Rhythm;
• raising arterial pressure;
• if the suppository is used, then a sense of finding a foreign object in the rectum can occur, as well as itching and burning in anus;
• bloating, nausea, no appetite, liver function, sometimes vomiting and diarrhea;
• anemia, granulocyptopenia.

special instructions

Interferon should be used to use patients with pronounced violations in the work of the heart or in the near-past past to the myocardial infarction. In thrombocytopenia, the drug is administered subcutaneously. Patients with violations in the work of the central nervous system must constantly keep controlled general state, and in case of aggravation of the clinical picture mental illness Treatment is immediately terminated.

Patients suffering from exacerbation of chronic hemorrhoids with bleeding nodes or rectal loss are contraindicated by rectal administration of interferon. If necessary, apply parenteral administration of the drug.

Interferon for children

Bad ecological situation or stress leads to the fact that children are born with anomalies and weak immunity. The child who has not yet fulfilled a year is very useful to give the drug interferon to help strengthen immunity, as well as an increase in the ability children's body resist viruses and bacteria.

Candles are recommended for very small and premature babies. They put their child twice a day for five days. Ointment is used Usually for the prevention, which lubricates nasal moves three times a day. It is also effective for the treatment of swollen almoths and stomatitis ulcers. It is very rare, but there may be such side effects as an increase in temperature, changing the nature of the chair, insomnia, migraine, dizziness, cramps, shortness of breath, allergies, rapid heartbeat, nausea.

It is impossible to use the drug interferon too long, as you can get used to it. This means is contraindicated in the presence of kidney pathologies, heart, central nervous system and intolerance to the drug component.

Drops interferon for children

A small child is the optimal solution is the parenteral administration of the drug (in the nose) in the form of droplets. This avoids the impact of the drug on the gastrointestinal tract. For instillation use ampoules with interferonwhich is bred and use immediately. The solution is prepared directly in the ampoule, adding 2 ml of water. The child boosts 4 drops of interferon in each half of the nose with gaps at 6 o'clock. If the drops are used in infants, then the gaps between the procedures are reduced to 2 hours.

The price of the drug Interferon in different cities may differ. This affects the region, manufacturer, volume of means, view dosage form. Therefore, the cost of the drug varies from 75 to 250 rubles.

In this way, interferon preparation Indispensable in the treatment and prevention of influenza and sharp respiratory viral infections. It can be used even to newborn children and pregnant women. Release the medicine most often in ampoules, in the form of rectal suppositories, and sometimes in the form of tablets.

Today's pharmacology is a large range of drugs with a great spectrum useful properties In the treatment of viruses and infections. One of these means is Interferon. Before use, you must read in detail with the testimony and contraindications of this medicine.

Composition, release form and manufacturer

Interferon is a preparation consisting of a mixture of various natural alpha interferon. The inductors of interferon from human blood leukocytes are obtained. It has several forms of release:

• Liophysiirt (dried drug underwater, used in the future to obtain a solution)
• 2 ml ampoules
• Suppositories for rectal and vaginal application
• Solution for injections or inhalation
• Capper Powder
• Spray can
• Microclisms
• Pills

The main function of the use of the drug is protection against non-specific viral infection. The composition is completely dependent on the form of the discharge of the drug, the packaging and its volume depends on the same.

Firms that produce interferon several are located in the United States of America, Russian Federation, Israel, Switzerland and other countries.

Indications for the use of interferon

Interferon refers to a group and drugs. Their work is aimed at stimulating the work of cells responsible for the formation of cellular immunity. The tool is intended for treatment:

1. C, B and D
2. Herpes eye

Apply it for the prevention of sharp respiratory infections and. The broad use of interferon also received for the treatment of cancer tumors of the lymphatic system, kidney, gastrointestinal tract. It is prescribed in the treatment of pathologies of nerve tissues and spinal cord.

Contraindications

The main contraindications of interferon are indicated in the instructions for use. These include:

• Heavy heart disease
• Problems in the functioning of the kidneys and liver
• Personal intolerance of the component composition
• Diseases of the central nervous system
• Problems with the work of the thyroid gland

It is impossible to give the drug to children who were born prematurely or were born earlier than 34 weeks of gestation. Contraindicated reception with unclosed intestinal bleeding. Special caution should be taken during pregnancy or during lactation. The dosage and the mode of receiving the drug should be coordinated with the doctor.
Medication mechanism

The basic effect of interferon is to inhibit the synthesis of viral proteins. The fight against the virus begins after a few hours after taking medication. The drug does not penetrate the cell, and acts on the membranes, entering into contact with specific receptors.

The maximum possible concentration of interferon in the blood is marked in the first 3-12 hours. The period of complete removal is 2-7 hours. After a day in the blood plasma, its traces are not detected at all.

The body is the following action:

1. Antoviral
2. Antitumorian

In the first case, the process of braking reproduction of viral cells occurs. In the second - the work of the drug is possible due to the content of protein P53. Regardless of the form of release and introduction to the body, the interferon has 100% bioavailability, that is, completely absorbed by the body.

Read more about the use of Interferon, look in our video:

Instructions for use

The daily dosage and form of the drug used are determined by the doctor, depending on the age of the patient, its diagnosis and the presence of related pathologies.

IN preventive purposes Interferon from influenza or similar infections is used 4-5 times over the week.

The most optimal form of release for this purpose is nasal. Each nostril is enough to drip 2 drops.

If you use the lyophysius of interferon, then in front of the injection, it should be divided into 2 ml of water. A similar method of use is suitable for breeding medication as a solution for inhalations.

The cooked solution should be stored no more than a day. Suppositories are prescribed for the treatment of herpes and papillomas of the virus. 1-2 times a day, candles are introduced rectally or vaginally a course no more than 10 days.

In the treatment of oncological diseases, the drug is injected intramuscularly. Dosage in each case is installed individually. When the course is chemical or radiation therapy Interferon should be taken for another 14 days after their completion.

Children's form of release can be ointment, candles and drops. Dosage, as in the case of adults, the doctor defines. It is allowed to use for infants.

In case of eye diseases apply eye drops (2 pcs. in each eye) Interferon. Daily dosage of the bundle - no more than 6 times. With a decrease in the manifestation of symptoms, the dosage decreases twice. The allowable duration of the course is 1-1.5 weeks.

Ointment is used to prevent ARVI. Twice a day it should lubricate nasal passages within 1-3 weeks. Interferon in tablets is allowed to receive no more than 2050m per kilogram of patient weight. The total dosage should not exceed 1 million IU. The earlier the course of treatment or prevention with interferon began, the higher the efficiency of the drug.

How to prepare an interferon solution for instillation into the nose, see in our video:

Side effects

When receiving interferon, no one is insured against occurrence adverse Reactions drug. Most often, their manifestation occurs in the first 2 weeks of reception. With further continuation of the course of symptoms side effect poke. The most common responses of the body to interferon are:

1. Strong headaches
2. Increase temperature up to 38 degrees
3. Fever
4. Muscle pain
5. Sustav pain
6. General malaise

In addition, disorders may appear in the functioning of digestive, cardiovascular and nervous systems, allergies, problems with the work of the respiratory organs.

Application during pregnancy

The use of interferon during pregnancy and during the lactation period is carried out under control and with the permission of the attending physician. There are no cases of negative influence on the development of the fetus and the body of the future mother.

During the use of the drug, nursing mom should observe the infection. Interferon in a small concentration falls into breast milkTherefore, an ambiguous reaction to him the baby will be a reason for refusing the medication.

Overdose

Interferon overdose cases were not detected. To prevent the development of adverse reactions should not be exceeded by the doctor or manual dosage in accordance with the patient's age.

Medicinal interaction

Care should be exercised when using interferon with other non-steroidal anti-inflammatory drugs due to the possible probability of additional liver load. This is especially true of patients who have a violation of the functions of the authority. The course of treatment is carried out in this case under constant medical inspection.

special instructions

When appointing interferon, it is necessary to ensure that the patient does not have problems with work of cardio-vascular system. It is not recommended to take it to people who recently suffered a heart attack.

When thrombocytopenia, the drug is introduced strictly under the skin.

People who passed the age of 65, the dosage is selected individually.

Contraindicated rectal candles Interferon with exacerbation of hemorrhoids or bleeding its nodes. Suppositories are not prescribed and in the outdoor form of the disease.

Children from an neonatal period (since birth) the drug is used intranasally (by spraying or injected). For children from 3 years and adults - additionally in the form of inhalation.

Intranasal

An ampoule with the drug is opened immediately before use. Sterile distilled or cooled to room temperature boiled water Add to a shift to the shock indicated on an ampoule corresponding to 2 ml, be carefully shaken until the contents are completely dissolved. The dissolved drug is transparent or slightly opalescent liquid, colorless or from light yellow to pink. The dissolved preparation can be stored at a temperature of from 2 to 8 ° C for 1 day.

The drug is used by injection (using a medical pipette or a syringe without a needle) or spraying. Spraying is made by sprayers of any system or using the attached spray nozzle.

For prevention, the administration of the drug should be started with the immediate threat of infection and continue until the danger of infection remains. The drug is used intranasally by instillation of 5 drops or spraying of 0.25 ml in each nasal stroke 2 times a day with an interval of at least 6 hours.

For treatment, the drug is applied to early stage Diseases when the first appearance clinical symptoms Intranasally 0.25 ml (5 drops) in each nasal stroke after 1-2 hours at least 5 times a day. The effectiveness of the drug is higher than the use of its earlier.

Rules for applying a spray nozzle:

To put on the needle on the syringe, fill it with a dissolved drug in a volume of 0.25 ml (marker 10 on the scale of 40 units. Or a mark 25 on a scale of 100 units.). Remove the needle and wear a spray nozzle tightly. To bring close to the nasal move the nozzle-sprayer and a sharp press on the piston of the syringe to injected the drug into the nasal stroke. Remove the spray gun, put on the needle and dial 0.25 ml of the drug from the ampoule in the syringe. Remove the needle, put on a spray nozzle tightly and introduce the drug in another nasal stroke in accordance with paragraph 3.

The spray nozzle is administered to a depth of 0.5 cm into nasal moves, pre-purified from the mucus. The patient should be in a sitting position with a slightly trapped head and remain in this position for 1 minute after the administration of the drug. It is allowed to use one nozzle only in one patient.

special instructions

The introduction of the drug by injection is strictly prohibited.

Apply with caution to persons with allergic diseases.

Application in pediatrics

Children from an neonatal period (from birth) the drug is used by spraying and instillation.

Application during pregnancy and lactation

There are no data on the experience of use in pregnant women. Therefore, the drug is applied to the appointment of a doctor, taking into account the ratio of expected benefits for the mother and possible risk For the fetus and child.

During the lactation, there is no restrictions on use.

Features of the influencemedicinal product to control the ability vehicle and potentially dangerous mechanisms

Does not affect.

Features of the influence of the drug in persons with impaired liver and kidney function and in gerontological practice

Not identified features of application medicinal preparation In persons with impaired liver and kidney function. No features of application in gerontological practice