Interferon is a drug that has a direct impact on the body's immune system. It has pronounced antiviral, antiproliferative, as well as antitumor effect.

Release form and composition

The internal substance of the drug interferon is a specific protein synthesized by human leukocytes.

The medicine is produced in the following forms:

• Lyophilized powder;
• Solution for local application;
• Injection;
• Rectal suppositories.

Indications for use

According to the instructions attached to the interferon, the testimony for its use depends on the form of the drug.

Injection:

• Hepatitis B and C;
• Condylomes are pointed;
• Leukemia, hairy cell leukemia - tricholecosis;
• Encephalitis tickle;
• Status after operational treatment respiratory papillomatosis of the larynx;
• Meloma Multiple;
• T-cell lymphoma - mushroom micaosis;
• Non-Hodgkin lymphoma;
• Chronic myelolomicosis;
• Reticulosarcoma;
• Sarcoma capos in patients with acquired immunodeficiency syndrome;
• Malignant melanoma;
• Thrombocytosis - primary (essential) and secondary;
• Chronic granulocyte leukemia and myelofibrosis are transitional forms.

Interferon in the form of suppositories:

• Hemorrhagic fever with renal syndrome;
• Viral hepatitis;
• Immunodeficiency states that are secondary.

The powder is lyophilized and a solution for local applications:

• Prevention and treatment of influenza, ORVI;
• Eye disease viral etiology.

Contraindications

The use of interferon is contraindicated in the following diseases and states:

• Hypersensitivity;
• Chronic cardiac failure;
• Acute myocardial infarction - acute period;
• Autoimmune diseases;
• Diabetes mellitus - heavy forms;
• Lung diseases;
• Liver or renal failure;
• Chickenpox;
• Cirrhosis of the liver;
• Diseases thyroid gland;
• Severe mental disorders, epilepsy;
• Lactation period.

The use of interferon requires caution during post-infarction cardiosclerosis, arrhythmias, simple herpes, bone marrow violation, as well as during pregnancy.

Method of application and dosage

According to the instructions, Interferon in injection solution Parenterally should be applied - subcutaneously, intramuscularly or intravenously drip. The dosage depends on the nature of the disease and age of the patient.

Interferon in the form of a powder and a solution for topical use is used intranasally and conjunction. The drug is injected by inhalation using an inhaler of any system or instillation aquatic solution - Powder before use is divorced into 2 ml of distilled or cooled boiled water.

In order to prevent influenza and ARVI, the medicine burst 5 drops in each nasal move twice a day with an interval at 6 o'clock.

In order to treat the drug Interferon should be applied to early stage Diseases with the appearance of the first symptoms of ailment of 5 drops after 1-2 hours at least 5 times a day for 2-3 days.

IN ophthalmological practice In the acute period of the disease, the medicine is introduced for 2-3 drops in each eye from 3 to 10 times a day. When improving the condition - up to 5-6 times during the day. The course of treatment is no more than 14 days.

Interferon in the form of suppositories is used rectally hemorrhagic fever, acute hepatitis In children, and secondary immunodeficiency states. The dosage is determined individually, the duration of treatment is not more than 14 days.

Side effects

Application of interferon, especially when parenteral administration, the following may be due side effects:

• Influencing syndrome - headache, Malgy, Fever, Chills;
• Decline in appetite, violation of the character of the chair, nausea, vomiting, dryness of the oral mucosa, heartburn, liver failure;
• Anemia, reducing the number of leukocytes and blood platelets;
• Pressure fluctuations, pain in chest, arrhythmias;
• Dizziness, reduction of cognitive functions and concentration of attention, sleep disruption, somnoleps, numbness of limbs or face, confusion of consciousness, paresthesia, seizures of calf muscles;
• Ambiguity of view, ischemic retinopathy;
• Dry skin, rash, itching, hair loss, hyperhydrosis;
• Disruption of the thyroid gland.

special instructions

During treatment antiviral drug Interferon needs to control blood analysis indicators and liver function. With pronounced thrombocytopenia, the medicine should be administered subcutaneously.

In case of side effects from the central nervous system In patients receiving high doses of medication, additional examination is required, if necessary, the abolition of the drug.

To reduce the severity of the flu-like syndrome, the parallel purpose of paracetamol is shown.

At the initial stage of treatment with interferon, hydration therapy is necessary.

In patients with hepatitis with antiviral agent may cause a violation of the function of the thyroid gland, so its use should be started only when normal level hormones.

During the period of use of the drug interferon, care can be taken when driving vehicles and other moving mechanisms.

Analogs

The synonyms of interferon include drugs alfaferon, diaiferon, interlock, intaferon, leukeinferon, Lokferon.

Similar to pharmacological action Possess drugs such as:

• Avonex;
• Alterevir;
• Betaferon;
• Viferon;
• Genfakson;
• Genferon;
• Ingaron;
• Lyifferon;
• Refaferon;
• Ecstati;
• Rebiff;
• Ronbetal and others.

Terms and conditions of storage

According to the instructions attached to interferon, the drug should be stored in a dry place at a temperature of 2-8 ° C.

Shelf life - 1 year.

IN modern world A person is subject to a variety of diseases. Especially often a person is sick, cold or flu. They are easily and efficiently allowed specialized drops.

However, with more severe diseases, such as warts on the skin, malignant diseases blood, diseases Herpes in AIDS patients need really serious medication treatment.

One of the effective drugs intended to combat different kinds of viruses and strengthening immune system Immunity - Interferon. The drug has an extensive spectrum of exposure, which allows it to be used as for the prevention of diseases, so for the treatment of a large range of diseases.

"Interferon" Sukhoi in ampoules was first released in 1957. Then Professor found out that this medicine eliminates the foci of the virus and does not allow the flu infection to multiply.

Today, dry "interferon" is sold in white or yellow ampoules. IN structure Medication includes leukocytes of donor blood, presented in the form of a mixture of proteins.

Applying the drug instantly absorbs the necessary elements. After that, the elimination of viruses begins.

Among side effects celebrate:

• skin diseases;
• nausea;
• headache;
• shiver.

Among contraindications celebrate:

• individual intolerance;
• violation of the functioning of the human immune system;
• remedy can start perceived as own fabrics organism;
• acute form ischemic Disease hearts;
• partial loss of kidney performance.

If you take a medicine for a long time, follow the composition of the blood and the functioning of the liver.

In what cases is possible use of "interferon"

For prevention:

• flu and colds;
• chronic hepatitis C;
• chronic hepatitis B;
• with a viral infection, in which a person is affected by fever and intoxication;
• oncopathologies, including Patients with AIDS.

For next diseases The medicine should be applied in treating:

• wart-shaped formations on mucous membranes and leather in the field of genital organs;
• plasma cell cancer;
• under skin oncological diseases;
• sarcoma Caposhi (in Patients with AIDS);
• leukemia with leukocytes with hair-bodied outgrowths;
• lesion bone marrow man;
• tumors in the kidneys and bladder;
• the formation of multiple papillomes on the mucous membrane of the larynx;
• significant increase in blood platelets;
• malignant tumor from reticular tissue.

It is worth noting that Interferon follows start applying at the first appearance of the disease. Thus, you effectively destroy the focus of inflammation and will go faster on the amendment.

Interferon Dry - Instructions for use

Usually "Interferon" is prescribed in the earliest stages of the disease. If you notice the first symptoms of colds or flu purchasing this medicine.

Dosage preparation for children and adults is identical.

It should be used by instilcing in the nose using inhalations or spraying. When spraying, enter by 0.25 ml Solid.

Open the ampoule per second before use!

For instillation in nostrils need to add purified water Before symbolism in 2 ml to the powder located in the ampoule.

Use the cure for six drops into each nostril. It is worth knowing that the interval between use should be about seven hours.

The duration of the course should not be more than five days.

Using medication is prohibited for thyroid diseases. If you have disorders of the liver and kidney, the use of medication is dangerous to health.

The use of medication for children up to two years is permitted only after consulting with the doctor.

Conclusion

In the cold season, a person is subject to cold illness Much more often than in summer. According to experts, best treatment Diseases are maintaining immunity throughout the year.

In cases of the imminent immune system and use "Interferon" for prevention. He, as a barrier disappoints you from viruses and a variety of infections.

Apply the drug only with the permission of your attending physician. Keep track of the shelf life of the medication.

Do not use the medicine if the packaging tightness is impaired.

Children from an neonatal period (since birth) the drug is used intranasally (by spraying or injected). For children from 3 years and adults - additionally in the form of inhalation.

Intranasal

An ampoule with the drug is opened immediately before use. Sterile distilled or cooled to room temperature boiled water Add to a shift to the shock indicated on an ampoule corresponding to 2 ml, be carefully shaken until the contents are completely dissolved. The dissolved drug is transparent or slightly opalescent liquid, colorless or from light yellow to pink. The dissolved preparation can be stored at a temperature of from 2 to 8 ° C for 1 day.

The drug is used by injection (using a medical pipette or a syringe without a needle) or spraying. Spraying is made by sprayers of any system or using the attached spray nozzle.

For prevention, the administration of the drug should be started with the immediate threat of infection and continue until the danger of infection remains. The drug is used intranasally by instillation of 5 drops or spraying of 0.25 ml in each nasal stroke 2 times a day with an interval of at least 6 hours.

For treatment, the drug is used at an early stage of the disease when the first appearance clinical symptoms Intranasally 0.25 ml (5 drops) in each nasal stroke after 1-2 hours at least 5 times a day. The effectiveness of the drug is higher than the use of its earlier.

Rules for applying a spray nozzle:

To put on the needle on the syringe, fill it with a dissolved drug in a volume of 0.25 ml (marker 10 on the scale of 40 units. Or a mark 25 on a scale of 100 units.). Remove the needle and wear a spray nozzle tightly. To bring close to the nasal move the nozzle-sprayer and a sharp press on the piston of the syringe to injected the drug into the nasal stroke. Remove the spray gun, put on the needle and dial 0.25 ml of the drug from the ampoule in the syringe. Remove the needle, put on a spray nozzle tightly and introduce the drug in another nasal stroke in accordance with paragraph 3.

The spray nozzle is administered to a depth of 0.5 cm into nasal moves, pre-purified from the mucus. The patient should be in a sitting position with a slightly trapped head and remain in this position for 1 minute after the administration of the drug. It is allowed to use one nozzle only in one patient.

special instructions

The introduction of the drug by injection is strictly prohibited.

Apply with caution to persons with allergic diseases.

Application in pediatrics

Children from an neonatal period (from birth) the drug is used by spraying and instillation.

Application during pregnancy and lactation

There are no data on the experience of use in pregnant women. Therefore, the drug is applied to the appointment of a doctor, taking into account the ratio of expected benefits for the mother and possible risk For the fetus and child.

During the lactation, there is no restrictions on use.

Features of the influencenia drug On the ability to manage vehicle and potentially dangerous mechanisms

Does not affect.

Features of the influence of the drug in persons with impaired liver and kidney function and in gerontological practice

Not identified features of application medicinal preparation In persons with impaired liver and kidney function. No features of application in gerontological practice

Form release

Structure

Activity: Interferon Alpha (Interferon Alfa) Concentration active substance (units): 1000

Pharmacological effect

Alpha Interferon is a mixture of various subtypes of natural alpha interferon from human blood leukocytes. It has antiviral, immunostimulating and antiproliferative effect. The antiviral effect of the drug is based mainly on the increase in the resistance of the cell cells that are not yet infected with the virus, to a possible effect. Associating specific receptors On the cell surface, the interferon alpha changes the properties of the cell membrane, stimulates the specific enzymes, affects the RNA of the virus and prevents replication. The immunomodulatory effect of interferon alpha is associated with stimulating the activity of macrophages and NK (Natural Killer) of cells, which, in turn, are involved in the immune response of the organism on tumor cells.

Indications

Prevention and treatment of influenza and other sharp respiratory viral infections

Contraindications

Increased sensitivity to protein preparations

Precautions

Caution is used in patients with instructions in history for the recently suffered myocardial infarction, as well as in cases of changes in blood coagulation and myelodepresses. Caution is used to use interferon alpha at the same time with sleeping pills, sedatives, opioid analgesics.

Application in pregnancy and breastfeeding

The use of interferon alpha drugs during pregnancy is possible only in cases where the estimated benefit for the mother exceeds the potential risk to the fetus. If necessary, applying a nursing mother during lactation should be resolved about the cessation of breastfeeding. Reproductive ages during therapy should apply reliable methods of contraception during therapy.

Method of application and dose

Children from an neonatal period (since birth) the drug is used intranasally (by spraying or injected). For children from 3 years and adults - additionally in the form of inhalation. Intranasally an ampoule with the drug is opened immediately before use. A sterile distilled or cooled to room temperature is boiled water added to the ampoule to a line indicated on an ampoule corresponding to 2 ml, gently shake up to completely dissolve the contents. The dissolved drug is transparent or slightly opalescent liquid, colorless or from light yellow to pink. The drug is used by injection (using a medical pipette or a syringe without a needle) or spraying. Spraying is made by sprayers of any system or using the attached spray nozzle. For prevention, the administration of the drug should be started with the immediate threat of infection and continue until the danger of infection remains. The drug is used intranasally by instillation of 5 drops or spraying of 0.25 ml in each nasal stroke 2 times a day with an interval of at least 6 hours. For treatment, the drug is used at an early stage of the disease in the appearance of the first clinical symptoms intranasally 0.25 ml (5 drops) in each nasal stroke after 1-2 hours at least 5 times a day. The effectiveness of the drug is higher than the use of its earlier. The rules for applying the spray nozzle: to put on the needle to the syringe, fill it with a dissolved drug in a volume of 0.25 ml (mark 10 on a scale of 40 units. Or a mark 25 on a scale of 100 units.). Remove the needle and wear a spray nozzle tightly. To the nasal foot of the spray nozzle and a sharp touch on the piston of the syringe to injected the drug in the nasal stroke. Attach the nozzle-sprayer, put on the needle and type 0.25 ml of the drug from the ampoule. Attach the needle, put the spray nozzle tightly and introduce the drug in Another nasal stroke in accordance with paragraph 3. The pump-sprayer is introduced to a depth of 0.5 cm into nasal moves, pre-purified from the mucus. The patient should be in a sitting position with a slightly trapped head and remain in this position for 1 minute after the administration of the drug. It is allowed to use one nozzle only in one patient. Inhalation is the most effective way For treatment is inhalation. It is recommended inhalers of any type. The contents of 3 ampoules are used per procedure, which is dissolved with 10 ml of water. Water is recommended to warm up to a temperature not higher than 37 ° C. Inhalation, the drug is injected through the mouth and nose 2 times a day for 2-3 days. The introduction of the drug by injection is categorically prohibited!

Side effects

Allergic reactions.

Interaction with other drugs

Since interferons inhibit oxidative metabolism in the liver, it is possible to violate the biotransformation of drugs metabolized by this way. When simultaneously use with aPF inhibitors It is possible synergism against hematotoxic action; with zidovudine - synergism with respect to myelotoxic action; with paracetamol - it is possible to increase the activity of hepatic enzymes; With theophylline - a decrease in the clearance of theophylline.

special instructions

When thrombocytopenia with the number of platelets, less than 50,000 / μl should be used by the development of side effects by the CNS in the elderly patients receiving interferon alpha in high doses, a thorough examination should be carried out and, if necessary, interrupt treatment. Podcients should be carried out hydration Therapy, especially in the initial period of treatment. Patients with hepatitis C receiving therapy by therapy by interferon alpha for systemic use, there are disorders of the function of the thyroid gland, expressed in hypo-or hyperthyroidism. Therefore, before the start of the course of treatment, it is necessary to determine the level of TSH in the serum and begin treatment only under the condition normal content TTG in the blood.

Interferon Human leukocytarial belongs to the drug with wide spectrum actions. It has not only antiviral property, but also antitumor, as well as antiproliferative spectrum of action.

Release form and preparation composition

Interferon leukocytarny human liquid: instructions for use

In all the instructions, it is written that the solution is used for local therapy, as well as for inhalation. A solution of 1000 IU / 1 ml can be released from a pharmacy of 5 or 10 ampoules. If the vial is prescribed, then the volume of the solution is 5 ml, released from the pharmacy 1 piece in the package.

In addition, there is a special lyophilisate, it is designed to prepare a solution. It is used for intranasal, as well as for inhalation therapy. The capacity of 1000 IU, if a solution for intramuscular administration is prescribed, then its capacity is larger, it is 10,000 mim it is one dosage.

Also, the drug is produced in the form of rectal suppository. The dosage is 40 000 me. Candles are released from the pharmacy of 10 pieces in one cardboard packaging.

Leiccitarian interferon: Indications for use

Since the drug can be used in different ways, then you need to know under what diseases it is assigned, and how it is properly applied.

Parenteral

Used B. complex therapy When hepatitis B and C. Also also helps to get rid of multiple myeloma, or conglishers, but only a pointed one.
In addition, parenterally is used in mycosis of fungal etiology, leukemia, as well as with a malignant melanoma.

Rectally (candles)
The use of candles in integrated therapy helps to get rid of the acute or chronic hepatitis, but only if the disease has viral etiology.

Intranasally or inhalation

In this case, doctors prescribe a means not only as treatment, but also for the prevention of sharp-respiratory diseases.

Interferon Human leukocytarial, also its instructions for use reads the use of a drug with other diseases, for example, with renal carcinoma, as well as complex treatment Sarcoma Caposhi.

Basic contraindications

The drug is not prescribed to everyone, there are certain contraindications.

• With violation of the functioning of the liver or kidney.
• If a person has heart disease with a severe severity.
• Diseases of the thyroid gland.
• With poor blood intake.
• Mielodepresses.
• Allergic reactions to the composition of the drug.

In addition, before applying the means, you must consult with the doctor. Preparation with caution is used in complex treatment with analgesics or sedative and sleeping equipment.

Side effects

Interferon leukocyte human dry and liquid has a number of side effects.

Influencing syndrome:

• Malgy.
• Chills.
• Strong headache.
• Pain in the back area.
• Fever.

From the digestive organs:

• Reduced appetite.
• Nausea.
• Diarrhea.
• Vomiting.
• The feeling of the metal taste in the oral cavity.

On the part of the blood formation organs:

• Anemia.
• Thrombocytopenia, as well as transient leukopenia.

From the side of the cardiovascular system:

• Strong pain in the field of chest.
• Reduced or increased blood pressure.
• Rarely occurs arrhythmia.

If it is incorrect to observe the dosage of the drug, violations of the nervous system may occur. The patient appears dizziness, insomnia, anxiety, numbness.

Side effects on the side of the skin may occur, for example allergic reaction, skin itch And dry skin.

Human forms of interferon: dosage

With each disease described above, the dosage of the medication and the form of application will be different. Therefore, we give a brief comparative table.

Important! Before use, it is necessary to consult with the doctor, only he will be able to assign a dose drug needed during your disease.

1. For example, under leukemia, 3 million meters are prescribed, the drug is used within 16-24 weeks, depending on the severity of the disease.
2. If the patient has skin T-cell lymphoma, then the remedy for the first three days in the same dosage. But, the following days of 9 million meters. Starting from 7-84 days, the dosage must be increased. Therefore, doctors are prescribed 18 million meters. A similar treatment diagram with chronic myelolomicosis.
3. When hepatitis (chronic), it is necessary to take the drug according to the scheme. The first 3 months of 6 million meters, then make a little break and repeat the course again. But, when hepatitis B is prescribed at 4.5 million meters, apply 3 times a week. The course of treatment of hepatitis B is 6 months.
4. As for hepatitis viral etiology, prescribe rectal candles, 1 suppositories per day for 10 days.
5. As the treatment of flu or for prevention, it is necessary to use powder. How to properly breed a dry mixture to the solution, you will tell you the doctor.

Special instructions and analogues

With simultaneous reception, the drugs below are violated the metabolic processes. It is also possible to strengthen the neurotoxic effect.

• Cimetidine;
• Warfarin;
• Propranolol;
• Diazepam.

From the analogs note:

• Diatoofon;
• Interlock;
• Interferon alpha-2 recombinant human;
• Inferno;
• Leucinferon.

Remember, analogues have additional spectra of actions and contraindications, so they independently do not use them in treatment, so as not to aggravate the course of the disease.
The cost of the medicinal product within 79 rubles.