The drug has a slight hypotensive, analgesic effect, adults are appointed and children.

The composition of the drug

Papaverin tablets include such a medicinal substance as hydrochloride papaverine. Each tablet contains 10 mg of the active ingredient and excipients (stearic acid, talc, sugar, potato starch).

Form release

Tablets are one of the forms of the release of Papaverin. In addition, the drug is produced in the form of rectal suppositories and ampoules with a solution for injection. Candles and injections have the same effect as a means for oral application. Tablets are produced in 10 pieces in one blister placed in cardboard packaging. Each package includes instructions for the use of papaverine tablets, from which you can find out detailed information about the drug.

pharmachologic effect

Consider what the Papaverin tablets apply and what action is the drug on the body. Adults and children medicine are prescribed to eliminate spasms and pain when different States. In addition, the medicine has a lung vasodinating actionDue to which it can reduce blood pressure.

Tablets help remove the spasm of smooth muscles of the uterus, stomach, intestines, gallbladder, bronchi, larynx, kidneys, bladder, blood vessels and some other organs.

After penetrating the active component in the blood, the activity of the phosphodiesterase enzyme activity occurs, which leads to a decrease in the amount of calcium in the human body, as a result of which the ability of smooth muscles decreases and this process slows down.

Indications

Take the drug only with the permission of the doctor. Independently carrying out the treatment with this tool is strictly prohibited, as it has some contraindications. Papaverin in tablets is recommended to apply for therapy of the following states:

• kidney colic;
• the inflammatory process of the gallbladder accompanied by spasm and painful sensations;
• spastic colitis;
• liver colic;
• to remove the tone of the uterus;
• in complex therapy bronchospasms;
• treating angina, recovery after a heart attack, stroke.

Papaverin eliminates spasm, has a slight painkillers

More often papaverine is prescribed as complex therapy for independent treatment The drug is applied less frequently, as it only removes the symptoms of one or another pathology.

Contraindications

Use papaverin should be used in a clear accordance with the instructions for use or by the diagram appointed by the doctor. Violation of the method of reception and dose of the drug may cause severe complications and side effects.

• the age of the child until six months;
• elderly age. Among the patients who have reached 65 years, the remedy is recommended to apply under the stringent control of the specialist;
• resistant hypotension;
• the presence of an allergic reaction to active Component preparation or its auxiliary substances;
• prema or coma;
• impaired atrioventricular conduction;
• glaucoma.

Dosage and methods of reception

Take Papaverin is needed according to a diagram of a doctor based on a patient's diagnosis. Tablets are designed for oral administration. Putting the medicine recommended water. Standard adult adult scheme - 3 tablets throughout the day. For children, the dosage is 1-2 tablets depending on weight, age and other individual characteristics. The duration of therapy is selected for each patient separately.

Dose and drug reception scheme are selected by a doctor

Application pregnant

How to take a medicine to women in the position? Papaverin during pregnancy is prescribed to patients with a leading physician in the presence of such testimony as an increased uterus tone, high blood pressure and some other states accompanied by a smooth muscle spasm. The dose of the drug is individually selected, it is usually 3 tablets throughout the day. The duration of treatment depends on the symptoms and the manifested therapeutic effect. In late pregnancy, the medicine is used to reduce pressure with uncomplicated gestosis.

Papaverin in pediatrics

What and in which dosage means are prescribed to small patients? Children Papaverin are prescribed from a semi-annual age if there are medical testimony. Patients under 4 years old are usually prescribed half a tablet 1-2 times a day. From 4 to 6 years old - 1 tablet, from 6 to 9 - 1.5-2 tablets. The duration of treatment for children is selected by a doctor depending on the diagnosis and clinical picture patient.

Side effects

Papaverin has predominantly positive feedback. Side effects develop extremely rarely. The cause of negative consequences becomes a dosage dosage and a medication scheme.

The main side effects on the background of drug intake:

• nausea;
• rarely vomiting;
• severe pressure reduction;
• rashes on an allergic body;
• eosinophilia;
• increased sweating;
• dyspeptic disorders;
• heart blockade.

To side effects include headache, nausea and other manifestations

Reception too large dose of the drug is able to cause a heart failure, drowsiness, bone in the eyes. With the appearance of these symptoms, it is necessary to immediately deliver the patient to the hospital, where the stomach is washing and other medical events.

Analogs

Analogs of Papaverin, similar to its indications and applications, are as follows:

• Riabal is shown to patients with diseases of organs digestive systemaccompanied by pain syndrome and spasm smooth muscles. The drug is widely used in the urinary system diseases;
• Dibazole - antispasmodic medicationwhich has a slight painkillers, vasodilatory, hypotensive effect. Among the testimony to use the drug, pathologies, causing spasms of blood vessels, exacerbation of hypertension, digestive diseases, accompanied by spasm, and other states are distinguished. A preparation is produced in the form of tablets and a solution for intravenous administration;
• Platifillain is a means of sedative, antispasmodic, analgesic effect on the body. Used medicine in the spasms of the stomach, gastritis, ulcers, acute and chronic pancreatitis, cholecystitis, bronchospasm, as well as to reduce arterial pressure With hypertension and other diseases of cardio-vascular system;
• But-shpa is a widely used drug used as additional therapy in many pathologies. But-shpa is appointed to eliminate spasms internal organs and blood vessels. The medicine helps to remove the pain syndrome in the pathologies of the gastrointestinal tract, diseases of the respiratory organs, heart and vessels, diseases of the urogenital system and other organs;
• Gastroomfort is a drug based drug, including cumin, dill, fennel and other components. The agent is prescribed to patients with diseases of the digestive system. Among the main indications - pain, spasms of the stomach and intestines, meteorism and other manifestations.

Dibazole - one of the analogues of Papaverin

Important! Each of the analogues has its own contraindications, so you can use them only with the permission of the doctor.

Medicinal interaction

In combination with other drug drugs, the effect of papaverine may increase or, on the contrary, decrease.

Enhance the effect of medication:

Before using Papaverin, you should inform the doctor about any preparations that are accepted by the patient or were taken on the eve.

Appoints a drug-based Papaverin exclusively doctor. A specialist picks up a dose and a drug reception scheme. The course of therapy usually lasts from 7 to 14 days before the complete elimination of pain.

With extreme caution give medicine to children. If the child has not learned to swallow the pill, it is recommended to crush it into powder, mix with a small amount of water, give the baby.

Strictly prohibited to combine papaverin with alcoholic beverages

With acute pain syndrome due to severe diseases of the gastrointestinal tract, respiratory and cardiovascular system, papaverine tablets should be replaced by injections.

The tool does not affect the concentration of attention and memory, so it can be assigned to patients with various professional activities.

Terms of sale and price

From the pharmacy, the drug is released according to the doctor's prescription, as it belongs to myotropic spasmolitics. Store the medicine is recommended at room temperature in protected places from children. The approximate cost of papaverine in tablets is from 25 to 35 rubles.

Patient reviews

Veronica, Volgograd

"Suffering ulcerative diseasewhich constantly aggravates. In a complex with other drugs, I take Papaverin tablets in the period of strong pain. Tool is cheap, but very good. Already 15 minutes after consumption, state alleviation comes. For several years of reception there were no negative consequences. I consider this medicine with the best spasmolitic system in the ratio of price and quality. "

Valeria, Izhevsk

"My hypertensive disease was diagnosed in a rather young age. Often experiencing headaches, weakness, apathy and other unpleasant symptoms. The attending physician appointed me Papaverin as auxiliary. Since then, always carry pills with you. The drug helps to cope with pressed, removes pain. The price of the medicine and its action is quite suitable for me. "

Elizaveta, Minsk

"I accept Papaverin with abdominal pain. I do not trust imported expensive funds, as I think that they are produced on the basis of the same active ingredients, but are much more expensive. Papaverin quickly eliminates spasm, facilitates the state. I recommend this drug to everyone. "

Maxim, Cheboksary

"Several years ago I found a urolithiasis. Since then, pebbles occasionally come out independently, as they have a small size. With pain during this period, Papaverin helps me. The process of outlet pebble becomes less painful. Justice I want to say that I would not advise to engage in self-medication, because it can happen renal colic. It is best to carry out treatment under the control of the doctor. "

"This drug was prescribed this father during the period of recovery after a heart attack for the normalization of blood pressure. Tool is cheap, but works perfectly. At least we have no problems with him. No side effects and complications arose. "

Papaverin instructions for use, composition, indications, analogues and reviews

The drug papaverine is a drug, the main active substance of which is papaverine hydrochloride. This active substance has an impact on smooth muscle elements, it causes their relaxation, therefore the drug is belonging to the group of myotropic spasmolitics.

Composition and form of release

Medication release form:

• Pills.
• Rectal suppositories.

The medicine is produced in tablets of 10 mg and 40 mg, fabricated in cell contour blisters of 10 pieces. Tablets have a white color, a bitter taste, do not possess any smell.

A solution of papaverine for injecting administration, produced in 2 ml ampoules was also used. In the cardboard packaging of the drug contains 10 pieces. You can find both papaverine candles or rectal suppositories that are designed to introduce into the rectum. The mass of each candle is 20 mg.

Papaverin - Instructions for use in various dosage forms

Papaverin: Application in the form of tablets

Instructions for the use of papaverine provides the possibility of using the drug with adults and children in various dosages. The dose of oral formation will depend on the age of a person. The following treatment diagram is used:

• From 0.5 to 2 years - dose of 0.005 g;
• From 3 to 4 years - 0.005-0.01 g;
• From 5 to 6 years - 0.01 g;
• From 7 to 9 years - application of 0.01-0.015 g;
• From 10 to 14 years - 0.015-0.02;
• Over 14 years old - 0.04-0.08

How to apply papaverine and reception in the form of a solution for injections

The acting component of the drug has a high biological accessibility, so injections can be made intramuscularly and subcutaneously or intravenously. At the same time, the therapeutic abilities of the papaverine, also does not affect the end result. At the same time, subcutaneous injections of Papaverin should not be done in the distal part of the forearm, and better - into the outer surface of the hip or shoulder, because the multiplicity of administration often leads to the occurrence of hematoma.

The intramuscular injections of papaverine can be performed according to the traditional scheme using the upper lateral quadrant of the buttock. Before carrying out intravenous injections, the amount of drug must be divided by a doctor, the amount of isotonic sodium chloride solution. It is necessary to recall that entering papaverin needs slowly so that in the injection process the person does not have unpleasant sensations. The contents of one ampoule are usually introduced subcutaneously.

Dosage of the papaverin solution with intramuscular and intravenous introduction as follows:

• For adults: 0.3 g daily and 0.1 g single;
• For children: up to 0.2 g daily and up to 0.06 g, one (depends on age).

Application of papaverin with hemorrhoids

For treating hemorrhoids, papaverin candles are used. Hemorrhoids itself is directly related to inflammatory processes, thrombosis, pathological extension of vessels that are looking through the intelligence of the rectum. Easy condition and cure the disease can candles.

According to the instructions, it is necessary to start a course of treatment with 0.02 g of the drug, increasing the dosage gradually to 0.04 g. (But only in cases where a smaller amount of the volume of the drug does not give the necessary therapeutic effect). In the instructions for use, it is noted that it is undesirable to use more than 3 candles in one day, because this can lead to the development of adverse effects, or cause an overdose, because the drug components in the rectal zone are too well absorbed.

Put candles papaverine is best in the morning and evening, before bedtime. If necessary, an additional candle can be put in lunchtime. Too often put candles are also not recommended.

Indications, contraindications, side effects of papaverine

Indications for Papaverin

The instruction of papaverine provides the following testimony for the use of the drug:

• Smooth muscle spasm (especially often during spastic colitis, cholecystitis, pylorosphasis);
• Hypertensive crisis (with a combined conservative treatment);
• ENDARTERIT;
• Kidney colic;
• Spasm of vascular peripheral channel;
• Reducing the lumen of the brain vessels due to the reduction of the muscular layer of the arteries;
• Bronchospasm;
• Angina;
• reduction of the renal arterial inflow of vascular genesis;
• Urine delay due to urinary tract spasms;
• Hemorrhoids, large hemorrhoidal nodes.

Papaverin is also often used before carrying out operational intervention associated with urological or proctological manipulations, with abdominal cavity. The drug allows you to relax smooth muscle elements.

Contraindications for using papaverine

You can select the following contraindications for receiving papaverine:

• Individual intolerance to the components of the drug;
• Violation of intracardiac conductivity (especially an atrioventricular blockade);
• High sensitivity to the drug;
• Severe liver failure;
• Glaucoma;
• Elderly age (there are high risks of the development of hypertensive syndrome);
• Children's age (up to 0.5 years).

As additional restrictions on the use of papaverine, the following states are (the drug can be used with regular observation of experienced doctors):

• The presence of a recent cranial injury;
• Chronic renal failure;
• Hypothyroidism;
• Shock states;
• Benign pancreatic hyperplasia;
• Supported tachycardia;
• Insufficiency of the functionality of adrenal glands.

From the cardiovascular system, an atrioventricular ventricular blockade may occur. Also often there is a decrease in blood pressure and tachycardia. In addition, according to the instructions among the main side effects Papaverin allocate nausea, constipation, bloating, increase the activity of hepatic transminases, violation of the passage along the digestive tube. Allergic reactions, drowsiness, eosinophilia may occur.

How long can you apply papaverine

The duration of the course of treatment is usually small, because immediately after the cessation of symptoms and eliminate the painful states, the drug is completed. The instruction on the use of Papaverin states that the drug can be used for a long time, in accordance with the courses appointed by the attending physician.

Papaverin: Application for children

Papaverin B. different forms (tablets, candles, injections) is actively used in pediatric practice Many countries in the world, starting from 6 months of age.

Drug Effects of Papaverin

Mechanism therapeutic effects Substances are influenced by messengers ( secondary intermediaries) Muscular excitation transmission. Papaverin inhibits phosphodiesterase, due to which cycloodenozin monophosphate begins to accumulate in cells. There is also a decrease in calcium ions. Smooth muscles in response to similar biochemical changes are beginning to relax, which is accompanied by a decrease in their tone.

The acting component of the drug is completely and rather quickly absorbed at different ways of introducing medication into the body. If it gets into the bloodstream, the substance begins to bind to plasma proteins, due to which through histohematic barriers passes with ease. Subjected to biotransformation in the liver. The half-life after receiving the means is from 30 to 120 minutes (the duration will depend on the additional components of the drug). It is excreted in greater the kidneys in the form of metabolic products.

Compatibility of Papaverin with but-shp

But-shp with papaverine, as with many of his analogues, interacts perfectly. The drug will have a therapeutic effect on the muscular smooth elements of the human body. The combined application of papaverine and but-shops is most often found in gynecological and obstetric hospitals with a high tone of the uterus, a serious threat of miscarriage or with too active generic activity ahead of time.

But-shpa and papaverine can be used in combination with any states that are conjugate with serious pain. The use of but-shops is not allowed in the presence of certain contraindications.

Among the analogs of papaverine, many different pharmaceutical forms can be distinguished medicines. Similar antispasmodic effect The well-known drug doll hydrochloride is capable of rendering, which is more common in our country called but-shp. In general, any drugs that give antispasmodic and anti-inflammatory effects can be attributed to the analogues of this medication.

Price of the drug in pharmacies

Check out the price of Papaverin in 2018 and cheap analogues \u003e\u003e\u003e The cost of the drug Papaverin in different pharmacies can differ significantly. This is due to the use of cheaper components in the preparation, and the pricing policy of the pharmacy network. But it is important that the price difference between overseas and russian analogues It remains almost unchanged.

What kind of medicine papaverine and how it acts

What is Papaverin? it drug Treatment, known for a very long time. It is used as antispasmodic in many countries. In the language of professionals, it is called papaverine hydrochloride. It can be purchased at a pharmacy in several drug forms. It may be tablets, candles or mortar. Its storage is 2 years. When visiting a pharmacy, it is necessary to take into account that candles and tablets are located in a free sale, and it will take a confirmation of the prescription to the solution.

How to act a tool

Papaverin can be assigned in two cases:

• to reduce pressure in the body;
• to remove pain in the muscles when spasms appear.

Its main substance is able to influence certain enzymes, therefore there is relaxing of the muscles of the internal organs. It helps relieve pain in digestive organs, vessels or lungs. Painfulness Pass, begins to fall pressure. If the dose of the drug is slightly increased, then the soothing effect will also appear. It is very often used in preparing a person to an operation that will be held under general anesthesia.

When using papaverine, it occurs its rapid propagation in the body through blood, regardless of the form used. The decomposition products of this drug are output through urine.

Usually it is prescribed to patients with various diseases. The form choose the most convenient for use.

But sometimes give preference to injections:

• with a sharp change in blood pressure;
• with a strong intestinal disorder;
• if the temperature of the body increases dramatically;
• with the loss of consciousness by the patient who needs urgent help.

• with pain in the stomach;
• with intestinal and gastric colic;
• in the case of constipation or disorders;
• under menstrual pains;
• in spasms B. bladder bubble or his inflammation;
• with a sharp reduction in the muscles of the bronchial wall;
• in the case of vessels of vessels in the brain area.

In case of individual characteristics, the doctor can use this drug:

• with colic in the kidneys;
• with inflammation of the gallbladder;
• with pain in the chest.

Sometimes it can be prescribed along with Dibazole. It helps reduce pressure. In this case, you need to make an injection injection or intramuscularly.

He is still prescribed along with analgin in ampoules. It helps to normalize body temperature, save the patient from pain. Such appointments will be relevant for patients who have undergone operational intervention.

How to use depends on the form:

1. Tableled form is used if necessary at any time and is wellhed with simple water.
2. Injections with papaverine can be done subcutaneously or in the muscle. It is best that this make a medical worker in the hospital, subject to all sanitary standards. If it is administered intravenously, then you need to dilute with saline.
3. Candles are usually used with pain in the area of \u200b\u200bthe pelvic organs. They need to be introduced into the anal hole.

So, Papaverin is an antispasmodic, which is produced in three various forms (Tablets, rectal use candles and a solution in ampoules). The choice in favor of this or that form makes the doctor on the basis of a number of parameters.

Dosage and possible contraindications

Papaverin has strict restrictions on the reception. It cannot be used to treat small children aged less than 6 months. The same rule applies to people who over 65 years old.

Who else is contraindicated Papaverin:

• in violation of the kidney work;
• with improper liver operation;
• when developing glaucoma;
• with a heart blockade;
• with rapid heartbeat;
• in case of incorrect work thyroid gland;
• with brain injuries.

The dosage must install the doctor in each case. Usually the means does not apply for a long time, but only if necessary. In the absence of the desired result and if the pains are not stopped, it is necessary to contact the hospital.

For adult patients, the dose should not exceed 60 mg, if necessary, it can be no more than 240 mg per one receive and 720 mg per day.

IN therapeutic purposes The doctor may assign:

• 3 or 4 tablets per day;
• 2 or 3 candles per day;
• 2 or 4 injections per day.

The form of selection depends on the set of conditions.

Use of pregnant and children

Sometimes the drug is used to treat children.

Description to the drug sets down dosage depending on age:

• from 6 months to 2 years old can be received no more than 5 mg;
• from 2 to 7 years, the dose should not exceed 10 mg;
• upon reaching 10 years, it can be no more than 15 mg;
• from 10 to 14 years old, it can increase to 20 mg.

For convenience, you can purchase tablets with a 10 mg dosage. If you need to use candles, they can be divided by half. Papaverin 40 mg is suitable for adults.

During pregnancy, it can be used only by appointing a doctor. Papaverin is not able to affect the course of pregnancy, but still it is better not to risk, especially in the later timing.

Sometimes a large amount of papaverine can provoke impairment of vision, the appearance of a split effect.

Papaverin - Instructions for use, reviews, analogs and form of release (Tablets 40 mg, Candles 20 mg, injections (in ampoules for injection)) drug for the treatment of spasms in adults, children and during pregnancy

This article can be familiar with the instructions for the use of Papaverin drug. There are reviews of site visitors - consumers of this medicine, as well as the opinions of doctors of specialists in the use of Papaverin in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of Papaverin in the presence of available structural analogs. Use for the treatment of spasms in adults, children, as well as in pregnancy and breastfeeding.

Papaverin is a mullopic spasmolitic. Reduces the tone of smooth muscles of internal organs (gastrointestinal tract, respiratory, urinary, sexual system) and vessels. Causes the expansion of the arteries, contributes to an increase in blood flow, incl. cerebral. It has a hypotensive effect.

In high doses, reduces the excitability of the heart muscle and slows down intracardiac conductivity.

When applied in medium therapeutic doses, the action on the CNS is expressed weakly.

Bioavailability is 54%. It is well distributed in the body, penetrates through histohematic barriers. Metabolized in the liver. Exammed by the kidneys in the form of metabolites. Completely removed from blood during dialysis.

• smooth muscle spasms abdominal cavity, bronchi, peripheral vessels, brain vessels, kidneys;
• angina (as part of combined therapy).

As a subsidiary for premedication.

Candles for rectal use of 40 mg.

Solution for injections (injections in ampoules) 20 mg / ml.

Instructions for use and dosage

Inside - POMS 3-5 times a day. Rectally - POM 2-3 times a day.

With intramuscular, subcutaneous or intravenous administration motherwise dose for adults make up The interval between the introductions is at least 4 hours. For elderly patients, the initial one-time dose is not more than 10 mg. For children aged 1 to 12 years old, the maximum one-time dose of output / kg.

• nausea;
• constipation;
• drowsiness;
• increased sweating;
• arterial hypotension;
• development of AV blockade, violations heart Rhythm (with rapid administration).

• AV blockade;
• glaucoma;
• severe liver failure;
• elderly age (the risk of developing hyperthermia);
• children's age up to 6 months;
• increased sensitivity to papaverine.

Application in pregnancy and breastfeeding

During pregnancy and during lactation (breastfeeding), safety and efficiency of papaverine is not installed.

C care to apply under states after a cranial injury, with chronic renal failure, with insufficiency of adrenal function, hypothyroidism, hyperplasia prostatic gland, religorakkova tachycardia, shock conditions.

Intravenously should be introduced slowly and under the control of the doctor.

During the treatment period, the use of alcohol should be excluded.

With simultaneous use with anticholinergic agents, it is possible to enhance anticholinergic effects.

It is believed that with simultaneous use with alprostadyl, there is a risk of developing priapism.

There are reports of reducing the efficiency of levodopes during its simultaneous use.

Reduces the hypotensive effect of methyldopes.

Analogs of the drug Papaverin

Structural analogues for the acting substance:

• Papaverin buffus;
• Papaverine hydrochloride;
• Papaverine hydrochloride MS;
• Papaverin hydrochloride solution for injection of 2%;
• Papaverin hydrochloride tablets for children0.01 g;
• Candles with papaverine hydrochloride 0.02.

Used to treat diseases: spasm, angina

After how much papaverin is absorbed

Almost every pregnant woman is familiar with the term "hypertonus of the uterus". This phenomenon is quite common, but the norm is not the norm and represents the danger to the course of the pregnancy up to its premature interrupt. Fortunately, modern medicine has a large arsenal of medicines that can effectively remove the voltage muscles. Among them are long-known and widely used Papaverin candles. Like any drug, this drug is possible to apply a pregnant woman only to the appointment of a doctor, but every future mother is useful to know all the nuances of its impact on the body and the basic rules of use.

Rectal Papaverin Candles - the most popular appointment of a doctor with uterine hypertonus

Although papaverine hydrochloride is actively appointed by the gynecologist with pregnant women for both outpatient and stationary treatment, the instructions for the drug interprets its use during the gestation (tooling the child) ambiguously. According to the manufacturer presented by recommendations, the safety of the use of papavmer is not established by future mothers. Of course, this circumstance in combination with the prescribed appointment of a doctor will be confused by a woman who is consciously related to the use of drugs during pregnancy.

It should be noted that clinical researches The effectiveness and safety of the use of the drug Papaverin in pregnant women were not really conducted. Nevertheless, the long-term practice of the use of Papaverin is completely unequivocally indicative of its positive impact on the course of pregnancy and at the same time about full safety for the fetus.

Candles with papaverine are appointed on any period of pregnancy in the presence or suspicion for the presence of the following states in a woman:

Hypertonus uterus is the most common diagnosis set during pregnancy. Hyperthonus is a stress of myometrium (muscle layer of the uterus), which may occur for a number of reasons (stress, excessive physical activity, hormonal causes, etc.) and can lead to premature interruption of pregnancy. Arterial hypertension - persistent increase in blood pressure is a fairly common phenomenon in late pregnancy. Colics (liver, kidney, intestinal, etc.) - sudden grabs pain caused by muscle spasm. Bronchospasm is a pathological narrowing of bronchi. A strong increase in body temperature (in such cases, papaverine is used as part of a lithic mixture).

Papaverin is able to have a positive effect and in constipation, if they are caused by muscle spasm (spastic constipation). In atonic constipation, which is caused by a decrease in the tone of the intestinal muscles, Papaverin will only aggravate the situation.

The drug Papaverin is produced in several pharmaceutical forms:

enclosure solution; rectal candles; pills.

During pregnancy, papaverin is most often prescribed - suppositories. This form has a number of advantages:

convenience and versatility of self-use of a woman; Full and rapid absorption of the drug through the rectum; Strengthening the therapeutic effect due to the close location of the uterus.

Each rectal Papaverin candle contains 20 mg of the active substance.

The active substance of this agent is papaverine hydrochloride - an antispasmodic of myotropic action. In this regard, the drug operates in two directions:

Removing the voltage of the smooth muscles of internal organs (the means affects not only the uterus, but also on the organs of other systems - urinary, digestive, respiratory system). Expansion of vessels and an increase in blood flow, due to which the drug is able to reduce blood pressure (hypotensive effect).

With regular reception of Papaverin, women note his sedative effect - the level of anxiety is significantly reduced, the heart rate is stabilized, which is not more positively affected by the course of pregnancy.

The mechanism of action of the drug in the form of rectal candles is as follows:

Suppository after the room in the rectum under the influence of body temperature is melted. The active ingredient is instantly absorbed into the blood. In the blood plasma, papaverin binds to proteins. The blood flow paveterin in all systems and organs of a woman, including in muscle tissue of the uterus. The active substance of the drug has a relaxing effect on the smooth muscles. Papaverin is excreted from the body kidneys in the form of metabolites (intermediate metabolic products).

The papaverine treatment diagram is prescribed only by a doctor in accordance with the individual characteristics of the body of a woman and the diagnosed diagnosis. As a rule, the period of receipt of the drug is 2-3 weeks, daily dose - 2-4 candles. Takes of the drug are distributed evenly during the day.

It is important to remember that papaverin candles are available only for rectal use - in no case should be used vaginally

The rules for the introduction of rectal candles are as follows:

Before entering the candle, you need to thoroughly wash your hands. Since when contacting with hands, the candles are melted very quickly, before opening the blister, you can hold the unassemmed candle in the refrigerator or under the jet cold water. For the introduction of the suppository, it is convenient to use disposable gloves or attacks. Enter the drug is better in the position of lying on the side. The candle must be placed for a muscular sphincter, pouring at 2.5-5 cm in depth. After the introduction of the tool, it is better to lie on the side for a few more minutes to avoid leakage. After completion of the procedure, the hands should be carefully flushed.

Enter rectal candles is the most convenient in the lying position

As a rule, candles with papaverine are transferred to pregnant women easily, however, in isolated cases (with long and uncontrolled reception), the following side effects may occur:

redness and itching of skin ( allergic reaction); drowsiness; dizziness; heart rate disorders; raising sweating; decrease in blood pressure; constipation; nausea.

Rectal candles with papaverine are contraindicated in the presence of the following states and diseases:

individual intolerance to the components of the drug; glaucoma; liver or renal failure; heart rate disorders; AV blockade (atrioventricular blockade).

Papaverin is used with caution in violation of the function of adrenal glands, hypothyroidism and arterial hypotension (reduced pressure).

The full analogues of rectal candles with papaverine are only drugs of other pharmaceutical forms of release - tablets and an injection solution. If we talk about the drugs of similar action, then in modern gynecology, such drugs like but-shpa, Magne B6, uremines are used. Their impact is based on the antispasmodic properties of other active ingredients.

Pain syndrome and pathological changes in the rectal region differ depending on the stage of the proctological disease.

Therapy delicate problem It is often carried out by contact means, so doctors sometimes prescribe papaverin candles with hemorrhoids.

The spasm of the rectum in combination with constipation impairs the patient's condition. Removing muscle compression and internal tension, papaverine candles make it easier kALOV MASS.which minimally injured pathologically modified areas of the rectal zone.

The effect of relaxation is ensured by the entry of the medicine into a group of myotropic spasmolitics that influence the special organism receptors that are responsible for muscle excitement. Expansion of vessels allows you to improve microcirculation, clean venous stagnation and prevent the risk of thrombus's risk in the presence of hemorrhagic nodes.

Having a laxative effect, papaverine also leads to the restoration of the tow truck function of the intestine after a few hours after the suppository is administered.

In the presence of inflammation of the mucosa of the rectum caused by hemorrhoidal nodes and the anal cracks, the tool turns out to be powerless (only smooth muscles relax). The main active substance is papaverine hydrochloride - also does not have wound-healing and hemostatic properties.

Introduction The suppository is ineffective in cases associated with damage to the mucous membranes and blood secretions, although the tool is sometimes used as auxiliary therapy.

Indications for use

The intestinal hypertonus leads to a climb of some areas of the digestive tract, which ceases to skip the digestible food. Meteorism, pain, feeling of overcrowding - characteristic manifestations of spastic constipation, which causes hemorrhoids or complicates its current.

The main grounds for receiving Papaverin:

• long constipation;
• spasms of the rectal area;
• strong pain in the rectum.

The drug works comprehensively (absorbed into systemic bloodstream), expanding all major arteries in the body. Thanks to this effect, papaverine is also accepted in spasms associated with other diseases and states: with cholecystitis, colic in the kidneys, intracranial pressure and spasme of brain vessels.

Instruction and dosage

Papaverin candles are used for the introduction into the rectum in order to quickly occur anesthetic effect. There are 2 types of funds on sale - 20 and 40 mg. Initially, suppositories with a smaller concentration of the active substance are used, and with weak exposure, a more "powerful" form is a candle of 40 mg.

1. When using suppositories, it is necessary to clean the intestine from the wheel masses, which are removed by either a natural campaign to the toilet or by refiscent.
2. To facilitate the introduction, you can additionally lubricate anus vaseline. The candle quickly melts when contacting the mucous membranes and is also quickly absorbed into the blood.
3. After entering the suppository, it is recommended to lie down for 20 minutes on the stomach or side.

Most used do not mark the leakage of the liquid from the anus when setting the suppository for the night. The daily limit on the number of supposed suppositories is 3 units. The maximum term of treatment is 14 days.

Medical fact. Candles papaverine act faster than painkillers.

Inflammation of hemorrhoidal nodes during pregnancy - will papaverine suppositories help?

The period of nursing the fetus is not considered a limiting condition for admission of papaverin, but the therapists prescribe it only in difficult cases associated with strong discomfort in pregnant women. Papaverin is used in women waiting for the appearance of a child, and in cases where there is a risk of miscarriage due to impaired muscle tone.

Rationality of admission during pregnancy:

• aggravation of hemorrhoids;
• hyperton;
• training bouts;
• high blood pressure.

You should also divide the rationality of the use of the product in different periods of navigation of the fetus.

1. The first triad. Hemorrhoids are less likely manifested during this period, but in the first weeks of pregnancy, some women are diagnosed with an excessive tone of the uterus, which will be bought by this medicine. In the first 3 months, the arrival of medication components is unfriendly: due to the lack of a fully formed placental barrier active substances Can easily hit the emerging child.
2. The second triad. Candles help pregnant to remove severe intrauterine and hemorrhoids, as well as symptoms increased pressurewhich are manifested in the middle of pregnancy.
3. Last triad. In a period of significant increase in the size of the fetus, frequent exacerbations of hemorrhoids are observed. At the same time, an excessive voltage of the uterine wall is formed - a state of complicating generation. Relaxing muscles, Papaverin prepares the neck of the uterus to the discovery and reduces the intensity of spasms during prenormal struggles, as well as minimizes the strengthening of the mechanical impact on the rectal area.

Important. Despite the relaxing effect, papaverin does not lead to miscarriage.

Side reactions and restrictions

At the beginning of therapy, the patient may feel nauseous, weakness, diarrhea and signs of hypotension. The overdose of the medication increases the risk of developing arrhythmia, increased sweating and atrioventricular blockade. At the CNS, the agent practically does not affect even when the permissible concentration is exceeded.

Taba on the reception of Papaverin:

• glaucoma and increased intraocular pressure;
• severe liver diseases;
• impaired heart conductivity;
• renal failure;
• intestine atony;
• age less than 6 months.

The state of the persons who have suffered a cranial injury and having thyroid disease are worse. It is difficult to endure the course of the papaverine person, in which the pressure is below the norm (hypotonics).

A warning. Nicotine and alcohol - forbidden substances during the course of Papaverin: Alcohol increases the risk of loss of consciousness, and nicotine minimizes an anesthetic effect.

Prices for Russia

The cost of candles with papaverine varies in different regions of the Russian Federation. Medication (20 mg suppositories) is produced by several companies, prices are represented in rubles.

Discounts on the means of papaverin are practically not found due to the relatively low cost of suppositories, however, when ordering candles in Internet pharmacies, a medicine can cost 2-5% cheaper. The cost of drugs with a dosage of 40 mg is slightly different - ranging from 5 to 10%.

Interaction with other medicines

Fully studied reactions with medicines of other therapeutic groups make it possible to draw a list of interactions with frequently used means.

Diagnosed changes:

• methyldop. Pressure reduction rate increases.
• Levodop. Anti-chakinsonic effect decreases.
• Antidepressants of the tricyclic group. The hypotensive effect is stronger. Similarly, the impact when used: reserpine, quinidine, procainamide.

If the use of papaverine intersects with the flow of barbiturate in the blood, the antispasmodic effect on the smooth muscles is enhanced.

Conclusion

Papaverin - effective toolwhich allows you to make relief in the expressed strengthening of hemorrhoidal pain. It can be viewed as a medicine emergencywho relieves the symptoms, but does not completely eliminate the proctological disease.

The remedy is sold without providing permits from a doctor, however, pregnant women should take into account the lack of studying the effect of the drug on the fruit. Waiting for replenishment in the family is rational to coordinate the reception of spasmolite with the attending physician.

Effective candles and ointments in the treatment of hemorrhoids: their price and impact

What can be used candles from hemorrhoids during pregnancy: efficient and inexpensive drugs

Instruction

The drug is a spasmodic of myotropic action. It is used in various pathological conditions, accompanied by spasms, painful sensations. The medicine quickly provides a positive effect, but care should be exercised during therapy due to the risk of developing various negative reactions.

Pharmacological group

Antispasmodic.

Structure

As an active ingredient, papaverine hydrochloride is used. In 1 suppository contains 20 mg of this substance.

Additionally, the composition includes solid fat.

Due to this component, the necessary consistency of the drug is obtained, but it does not contribute to strengthening pharmacological action. Suppositories can be purchased in the package (10 pcs.).

How to act Papaverin candles

The main property of the drug is antispasmodic. At the same time, the drug contributes to the relaxation of the walls of the vessels.

Pharmacodynamics

Papaverin (candles) is a opium alkaloid. The positive effect of therapy is achieved by the ability of the substance to have a relaxing effect on the muscles of the internal organs and the walls of the vessels. As a result, the voltage is reduced in soft tissuesThere is a slight decrease in blood pressure.

The mechanism of the action of papaverine is based on the inhibition of phosphodiesterase - substances that promotes potassium output from cells and reduce the calcium content. As a result, a relaxing effect is ensured, a weak effect on the central nervous system. Papaverin also has an impact on the ability of the heart muscle to excitement - when applied, intracardiac conductivity can slow down.

The drug is not analgesic, but manifests an anesthetic effect. Such an effect is ensured by eliminating spasm.

Pharmacokinetics

Rectal suppositories are quickly absorbed by mucous membranes. Papaverin bioavailability is 54%.

The substance penetrates blood through histohematic barriers.

As a result, the binding of the drug with blood proteins increases (90%). Transformed with the participation of the liver. The active substance is derived from the body for 50-120 minutes. In some cases, 24 hours leaves for the excavation of the main component.

For what candles are prescribed Papaverin

It is permissible to use the drug with such pathological conditions:

1. spasm of abdominal organs with colitis, cholecystitis;
2. renal colic;
3. high degree of voltage of peripheral vessels;
4. breast pain caused by developing ischemic disease;
5. spasm of brain vessels;
6. impaired respiratory function, for example bronchospasm;
7. outdoor, internal hemorrhoids;
8. spasm of urinary tract;
9. violation of potency when the cause is a spastic state.

Contraindications

Papaverin is not assigned in such cases:

1. intolerance of the active substance;
2. diseases accompanied by an increase in intraocular pressure;
3. atrioventricular blockade;
4. severe liver damage;
5. elderly age, in this case the risk of heat accumulation is increasing, which leads to hyperthermia (body temperature increases).

How to take ppaverine candles

Enter 1 candle 2-3 times a day. If necessary, a single dose increases to 2 suppositories, while the reception frequency is reduced during the day.

Is it possible to use candles vaginally?

In the manufacturer's instructions, there is no information on the use of medication in gynecology. However, in some cases, intravaginal can be used as an exception.

Candles are injected into the vagina with the tone of the uterus and for softening the cervix.

There is a positive result in violations menstrual cycleIf severe pain appear.

Where and how to enter?

The drug is applied rectally. To increase the efficiency of the drug, it is recommended to use suppositories after defecation or pre-make a cleansing enema.

How fast do candles act?

Improvement occurs within the first 30 minutes after the introduction of the medicine into the rectum.

How many candles can be per day?

Duration of application

The course of therapy depends on the initial data: the age of the patient, the condition of the body, the type of pathology, accompanied by spasm and pain, as well as the presence of other diseases.

The average duration of treatment is 5 days.

During this time eliminated acute signs pathology. Sometimes the course of therapy is prolonged up to 7 days.

With cystitis

Apply a standard treatment scheme (20 mg 2-3 times a day). The length of the course of therapy varies from 5 to 10 days. In chronic genital infections, the duration of treatment can be increased.

Application in children

The drug is not appointed to children under 6 months.

Side effects

During treatment, such negative reactions may appear:

1. atrioventricular blockade;
2. allergic reactions: itching, rash, redness of external covers;
3. violation of the reduction process of the heart, which provokes the development of arrhythmias;
4. hypotension;
5. the difficulty of death of feces;
6. drowsy state;
7. the amount of eosinophils in the blood increases;
8. the activity of hepatic transaminase increases.

Overdose

When using a large number of suppositories, there is a strengthening of some symptoms: drowsiness, allergic. Given that the drug is introduced rectally and quickly absorbed by the walls of the rectum, the washing of the stomach in this case will not provide the desired result. It is necessary to conduct symptomatic therapy.

Features of application

The drug is used with caution in patients in a weakened state (after illness), with impaired kidney function, endocrine system, adrenal cortex, with prostate tissue hypertrophy, anaphylactic shock, tachycardia. In these cases, the drug is not prohibited, since it improves peripheral blood circulation, but it should be more carefully observed for the condition of the body.

Papaverin in the form of candles does not apply under therapy of athletes. A more convenient form of release - solution, pills.

During pregnancy and lactation

Studies of the effect of papaverine on the fruit were not conducted. For this reason, this tool can be assigned if the positive effects are stronger possible harm. In the early time it is better not to use candles, since the threat of miscarriages increases.

The agent is used in 2 and 3 trimesters.

For breastfeeding The drug is prescribed at the discretion of the doctor, since the safety of use during this period is not established.

Influence on the concentration of attention

It is not recommended to engage in activities requiring increased care, with the treatment with the product under consideration. This is due to the ability of hydrochloride papaverine to influence the concentration of attention, the rate of reactions.

Medicinal interaction

With other drugs

The intensity of the effects of anticholinergic agents on the body increases.

With the simultaneous use of papaverine and Levodopa, there is a decrease in the efficiency of the latter. The activity of the components of methyldopes exhibiting a hypotensive effect is also reduced.

Compatible with alcohol

If alcohol-containing drinks are used during papaverine treatment, the likelihood of the development of hypotension and the occurrence of a fainting state increases.

Terms and Storage Terms

Conditions of vacation from pharmacies

Do you sell without a recipe?

The drug is a non-advice.

How much is

The average price is 80 rubles.

Analogs

Papaverin suppositories can be replaced by another form of a given means with a solution or tablets. Other common analogues:

1. But-shp;
2. DROTAVERIN;
3. Spasmol.

These drugs contain the same active component - drochloride hydrochloride. This is an effective antispasmodic substance, it just like Papaverin is a myotropic agent. These analogues contain an active ingredient in the same dose - 40 mg, which makes them interchangeable.

Update: October 2018

Papaverin is a spasmolitic drug, which is actively used to reduce the contractile function of smooth muscle fibers and reduce muscle tone, which leads to rapid relaxing of smooth muscles. It is derivative of opioid alkaloids and is made by synthesizing.

Assigned to eliminate spasms of biliary tract, ureters, gastrointestinal tract, reduction of the tone of the uterus. Used as a vasodulating drug for a coronary blood circulation system with subarachnoid-type hemorrhages and coronary shunting, as well as in a number of other cases.

FarmGroup: Motropic antispasmodics.

Composition, physicochemical properties, price

Produced in three forms: rectal candles (suppositories), tablets, injection mortar.

pharmachologic effect

Papaverine hydrochloride is an inhibitor (delaying in-B) of the phosphodiesterase enzyme and leads to the accumulation of cyclic 3.5-adenosine monophosphate, a decrease in calcium levels inside cells, which causes a disruption of the reduction of muscle fibers and relaxes the smooth muscle structures of internal organs and vessels. In medium healing doses, it has influence on the central nervous system. In high doses leads to a decrease in the excitability of the muscle tissue of the heart and slows the rate of intracardiac conductivity. A feature of the drug is the absence of a paralytic effect - the muscles are only relaxing, with their movements and functions are fully saved.

In addition to the antispasmodic effect, the drug has a moderate local dischairing effect, is characterized by minor hypotensive and sedative properties.

Pharmacokinetics

Completely and quickly absorbed, it comes into contact with plasma proteins by 90%. Penetrates the hematorecephalic barrier and in all the fabrics. Undergoes biotransformation in the liver. The half-life fluctuates in the limit of 0.5-2 hours. Announced by the kidneys in the form of metabolites.

Indications

• smooth muscle spasms;
• gPC spasms on the background, spastic colitis;
• pylorospasm;
• spasms of vessels of the peripheral channel;
• spasms of vessels CNS;
• heart vessels on the background and (in comprehensive treatment);
• urinary delay against the background of a spasm of urinary tract;
• bronchospasm.

It is appointed as an auxiliary drug for premedication to surgical interventions on the gastrointestinal tract, proctological and urological procedures.

Contraindications

• AV blockade
• Heavy
• Old age more than 75 years
• Children's age up to six months (up to 12 months - by other sources)
• Increased sensitivity to the main or auxiliary components.

Papaverin during pregnancy

Candles with papaverine during pregnancy are quite often prescribed by doctors. The main reason for the prescription of the drug is the hypertonus of the uterus, which, as is known, is one of the reasons for the unbearable of the fetus (especially often papaverine is appointed in the early periods of pregnancy), as well. Since the uterus is a muscular organ, for its relaxation and prescribe the drug, very often in combination with hormonal drugs.

In combination with but-shop, papaverin is assigned in the late launchers to prepare the cervix to the generic activity. However, many obstetric gynecologists against such training, since this leads to an artificial braking of the contraction of the uterus and.

In the instructions for Papaverin, it was noted that the effect of the drug during pregnancy and lactation is not studied, so it is impossible to argue about its security. This means that the appointment can only carry out a doctor, weighing possible benefits and risks. How much and how to take Papaverin, must say the attending physician, self-proof is unacceptable.

Papaverin Children

In children, under the year, the main testimony for treatment is spastic pain tract and intestinal colic. Older children are appointed for removal of bronchospasm, with, urethra spasms, liver colic.

Another scope of application is the removal of spasms of peripheral vessels against the background of hyperthermia: Papaverin is given 20 minutes to the antipyretic.

Side effects

• General: Hyperthermia (especially in the elderly).
• The immune system: Allergic phenomena, skin hyperemia and rash, itching.
• CNS: Increased sweating, drowsiness, dizziness, weakness,.
• Vision organs: reduced vision, diplopia.
• GET: nausea, diarrhea, constipation ,.
• SCCs: asistolia, arrhythmia, ventricular extrasystole, ventricular fibrillation, arterial hypotension, collapse.
• Respiratory system: apnea.

Against the background of treatment, probably increased activity of liver transaminases and development. Eosinophilia is possible.

With quick intravenous administration or when assigned in high doses, AV blockade may develop. Thrombosis is possible at the injection site.

Dosage

Dosage papaverine is different for various dosage forms and different age groups.

Pills:

• Adults and children from 15 l: 40-60 mg three-five times in day.
• Children 6-24 m: 5 mg (half of the tablet 10 mg) three or four times in court.
• Children 2-4 years: 5 - 10 mg three or four times in day.
• Children 5-6 years old: 10 mg three-four-fold in day.
• Children are 7 years old: 10-15 mg three-four-four times in court.
• Children are 10-14 years old: 15-20 mg three-four-four times in court.

The use of papaverine in tablets for children younger age group should be carried out after pre-dissolved in water.

Candles:

Enter rectally. Suppository can be cut.

• Adults: 20-40 mg (1-2 candles) two-three-time in court.
• Children from 10 years: 20 mg (1 candle) 2 P in day.
• Children 5-10 years old: 10 mg (half graffiti) 2 p per day.
• Children up to 4 l: 5 mg (quarter candles) 2 P in day.

Solution (pricks of papaverine):

• One-time dose for adults and children from 14 years with intramuscular and subcutaneous administration (injections) is 10-40 mg, and the maximum one-time is 100 mg (or 5 ml of r-ra). Between the introductions, 4 hours of interval should be observed. Maximum dose per day - 300 mg (15 ml of r-ra).
• For intravenous administration, which is considered the most effective, 1 ml of 2% p-ra (20 mg) is dissolved in 10-20 ml of P-ra NaCl 0.9%, which is a one-time dose. Maximum daily dose - 120 mg (or 6 ml of r-ra). In / in the introduction is justified when severe condition Patient, after 3-4 days it is recommended to go to tablets or candles.
• For children 1-14 years, the maximum one-time dose is calculated individually and is 0.7-1 mg per 1 kg of weight. Number of administrations: 2 P in day.
• The maximum daily dose depends on age and the same for all method of administration:
  • 1-2 years - 1 ml of p-ra (20 mg);
  • 3-4 years - 1.5 ml of r-ra (30 mg);
  • 5-6 years - 2 ml of p-ra (40 mg);
  • 7-9 years - 3 ml of p-ra (60 mg);
  • 10-14 years - 5 ml (100 mg).

Features of the application of the solution

The drug can be administered subcutaneously, intravenously and intramuscularly. In / in-introduction spend slowly, controlling the performance of the heart, especially in patients with stenzing coronarrikerosis.

Overdose

Violation of vision, weakness, redness of the skin, dry mouth, arterial hypotension, constipation, ataxia, asistolia, tachycardia, golder fluttering, collapse.

There is no specific antidote, therefore symptomatic treatment is organized, and in severe cases hemodialysis.

Features of treatment

Since smoking reduces the effectiveness of papaverine, it should be abandoned from the habit of at least for the treatment. Alcohol can also be used in conjunction with papaverine (potentiate the effect of alcohol).

During therapy, you should refuse work and activities where the reaction rate is important.

For elderly patients, patients with CHHMT, CPN, supraventricular tachycardia, decompensated, diseases of the endocrine system, the initial dose is set below the medium-designer, most often no more than 10 mg (or 0.5 ml of 2% RR).

Medicinal interaction

• Compatible with dibazole without the development of negative reactions (to relieve a hypertensive crisis).
• A combination with anticholinergic agents - an increase in anticholinergic action;
• Application with alprostadylin in the intracaverno administration is possible the development of priapism;
• Co-use with levodopa leads to a decrease in the efficiency of the latter;
• In combination with methyldop, a hypotensive effect is reduced;
• When prescribing with cardiac glycosides, the contractile function of myocardium is enhanced;
• For sharing with antihypertensive preparations, procanamide tricyclic antidepressants, reserpine, quinidine, novocainamide is enhanced by a hypotensive effect;
• There are data on the development of hepatitis during combination with furadonin.
• Barbiturates, metamizole (analgin), diphenhydramine (diphedrol), enhance the spasmodic effect of papaverine.

Analogs

Papaverin buffus, papaverine hydrochloride MS, Papavin.

At the time of pregnancy, there is a choice in front of many young ladies: do all sorts of drugs, even if they are spelled out by a doctor, or still better abandon them? But this wonderful period lasts not one week or month, so drug treatment It may be needed to eliminate all sorts of physical inconveniences and poor well-being.

Often in the list of prescribed medicines contain candles with papaverine. The use of this drug is very acquitted, and its safety in the days of pregnancy is tested and certified by generations.

During pregnancy, doctors strongly recommend to refrain from the use of all kinds of drugs. However, some of them are still included in the list of permitted, since at this time it is forbidden to endure pain or ignore any disorder. These sensations can be associated with many factors, and with pregnancy as well. Therefore, if the doctor's recipe includes the reception of pharmacy drugs, it should be very serious about this.

Many drug substances can only be in favor of mother and baby, and papaverine is no exception. Candles will not only soften and reassure painful feelingsBut also serve as an excellent antispasmodic element that eliminates vascular and muscular spasm, as well as capable of lowering pressure, and relax muscle tissues. The effect of papaverine is directed to the muscular fabric of the internal organs. However, its influence is directed only for smooth muscles, transverse fabrics does not apply to its influence.