Amoxiclav affects many types of pathogenic bacteria. The drug combines two active ingredients that show antibacterial activity - amoxicillin and clavulanic acid. In the pharmacy network in stock drug of different shapes Release and dosage. How to take amoxiclav and for which scheme, depends on the mass and age of a person, the nature of the disease and other concomitant factors.

The effect of the drug

Amoxiclave is a combined antibacterial agent of a group of penicillins. In addition to amoxicillin, it includes an β-lactamase inhibitor. Due to this, the antibiotic amoxiclav is more effective compared to the predecessors. The components of the drug are comprehensive:

• Amoxicillin disrupts the synthesis of protein in the cell walls of bacteria, thereby disturbing the process of dividing and growth, and as a result, causing death. But the portion of microorganisms adapted to resist the antibiotic using beta-lactamase;
• Clawulanic acid is inactivating the mentioned enzyme and restores the antimicrobial activity of the antibiotic. But, some bacteria strains exhibit resistance to amoxyclav, even despite this.

The antibiotic has a high bioavailability, quickly absorbed at oral use. Displays mainly with urine. An insignificant amount of the drug comes into breast milk, so doctors are often prescribed amoxyclav during lactation.

Indication for appointment

Doctors prescribe a reception of amoxiclava with the following diseases:

• diseases respiratory tract;
• ENT diseases (angina, hyimorite);
• inflammation of the urinary tract;
• states after surgery on the pelvic organs.

Also, amoxiclav is shown in pyodermia, inflammatory diseases of the skin and muscle tissue (helps with infected burns, wounds or bite).

Mode of application

The dosage of the drug is calculated, based on the age and weight of the patient, the severity of the disease and the functional ability of organs that excrete drugs and metabolites. Usually adults are recommended to take an antibiotic 2-3 times a day according to the scheme. The complicated course of the disease involves the reception of an antimicrobial agent in the amount of 1 g twice within 24 hours. The greatest daily dose of adult medication is 6 grams.

If the age of the child is more than 12 years, then dosage is used for adult. It should be borne in mind that self-treatment is dangerous. The drug must be taken on the recommendation of a specialist and following the indicated dosage. The reception scheme designed for an adult usually has the following form:

• 250 / 125mg every 8 hours;
• 500/125mg with an interval of 12 hours;
• 500/125mg is prescribed with a complicated course of the disease every 8 hours.

After 2-3 daytime use of tableted amoxiclava in adult patients, the severity of the disease symptoms is reduced and the patient's condition is improved. But it is impossible to interrupt therapy, even if the feeling is fully normalized. The duration of the treatment of an adult should not be less than 5 days.

Features of application

Meal does not affect the assimilation of the drug, but in order to avoid nauseous and irritation of the dump truck, correctly take amoxiclav at the beginning of food or immediately after it. The greatest concentration of the substance in the blood is observed in an hour after its adoption. With prolonged treatment with the drug it is possible to develop superinfection by bacteria and mushrooms, resistant to the action of an antibiotic, which requires its abolition and appointing appropriate treatment.

Tablets should be taken, not chewing. If it is impossible to swallow the tablet, you can grind it and dissolve a small amount of water. Apply amoxiclav in such a way convenient to the people of old age. Amoxiclav for adults is allowed to apply in pediatric practice Only after reaching the child for 6 years. Preschool children and children early age It is necessary to give amoxiclav in the form of a liquid suspension.

List of amoxiclava analogues

According to the reviews of doctors, the analogues of the drug Amoxiclav produced by Switzerland (No. 15, 375 mg) - the price of 190 rubles, are inexpensive and high-quality antibiotics:

• Oxep - from 75 rubles;
• Augmentin - from 390 rubles;
• Ecoclav - from 175 rubles;
• Rapiklav - from 338 rubles;
• Artlets - 284 rubles.

In general, domestic analogs are cheaper.

Contraindications and side effects

The Amoxyclave preparation is well tolerated and rarely causes concomitant negative phenomena. As a rule, they occur if the patient exceeds the specified dosage and the reception scheme, or if the patient has contraindications or individual intolerance between the active components of the antibiotic. Side effects are most often manifested at the beginning of the reception and gradually disappear over time.

Possible sideflines, Which is described in the instructions of the drug Amoxiclav:

• nausea, vomiting, heartburn, intestinal distention.
• peristaltics disorders.
• headache and disorientation.
• allergic reactions (rash, hyperemia, itching).

In rare cases, symptoms of intoxication, sleep disorders, pathological changes in blood composition are possible. The probability of overdose when using large doses of the drug Amoxiclav is very low. In this case, symptomatic treatment is necessary.

Article Verified
Anna Moschovis - family doctor.

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Amoxiclav - a new generation antibiotic, which is against a wide range of pathogens of microorganisms. Amoxicillin included in its composition and clavulanic acid together is effectively fighting with strains of infections that are sensitive to both. It has several forms of release with different dosage, which allows you to build a correct balanced course of treatment.

Composition and form of release

Composition and form of release

The antibiotic includes amoxicillin, which is a semi-synthetic penicillin, in its properties is close to ampicillin, but has better suction. Known with its antibacterial activity. The next ingredient is clavulanic acid. It is included in the list of irreversible inhibitors - lactamas. It contributes to the establishment of amoxicilline immunity to the influence of beta-lactamas produced by pathogenic bacteria. Clawulanic acid, as a separate unit, does not have a pronounced antibacterial ability.

Each pill is contained both ingredients, the volume of clavulanic acid is 125 mg, the content of amoxicillin in the form of trihydrate is 875 mg.

As additional components, silicon is colloid dioxide, the content of which is 5.4; Crosspovidon in the volume of 27.4, sodium crossarmellos 27.4 mg, magnesium stearate 12, microcrystalline cellulose up to 1435 mg.

Properties

Amoxicillin refers to semi-synthetic penicillins, according to the properties of close to ampicillin, but with better bioavailability during oral administration. It has activities against most gram-positive and gram-negative microorganisms. Destroys the biosynthesis of peptideoglycan, building material for bacteria. What, in turn, leads to the destruction of microorganisms. Amoxicillin itself is destroyed from the effects of beta-lactamas, therefore, against microorganisms produced by this enzyme it is powerless.

Clawulanic acid, in turn, is a braking factor just for beta-lactamas. According to mine physical characteristics close to penicillins. But the bacteria that have immunity against penicillin and cephalosporin can be coagped. This acid is effective in combating plasmid beta lactamases.

Clawulanic acid prevents the decay of amoxicillin under the influence of beta-lactamas. This property allows you to increase the antibacterial effect.

The following bacteria reacts for a tandem of clavulanic acid with amoxicillin:

1. Gram-positive bacteria: the pathogen of the Siberian ulcers, enterococcus the fecal, causative agent of listeriosis, bacteria of streptococciine, beta-hemolytic from the group A, staphylococcus saprofit.
2. Gram-negative aerobes: Cocktle stick, hemophilic chopstick, Helicobacter Pilori, Mooraxella Catarlis, Gonococcus, Pastellosis, cholera vibrion.
3. Other microorganisms: Burreliosis pathogens, leptospirosis, pale treponema.
4. Gram-positive anaerobes: Klostridia, peptococci, peptopulationococci.
5. Gram-negative bacteria: fragilis bacteroids, types of bacteroids, capofocytophages, plata wand, fuzobacteria, Porfirononda species, Prevhella. Some bacteria are able to adapt to the actions of amoxiclava. From among gram-negative aerobones, this is an intestinal wand, Klebseyellay oxite, Fredlender's wand, Chlebseyella Pneumonia, Klebsiella, Act Mirabilis, Vulgaris Proteus and Proteus, Salmonella, Bacteria of Schigella.
6. Gram-positive aerobes: Corinbacterian bacteria, Enterococci Fethium, Pneumococcus, Streptococci Group of Viridans. There are a number of microorganisms that possess natural resistance to amoxycular components 875 + 125.
7. Gram-negative aerobes: types of the genus of asinobacter, Citrobother Freudi, types of Enterobacter, Gafnia, Legionell Pneumophil, Morgan Bacteria, species of Providence, species of pseudomonads, species of SERRECTION, Stenotrophomonas Malto, Yersinia Enterocolitics.
8. Other bacteria: chlamydophil pneumonia, chlamydophila psyche, bacteria of Chlamydia, causative agents of kokoxylosis, species of mycoplasma.

In their actions, both main ingredients are similar, they actively disagree in aqueous solutions And after the procedure, it is rapidly starting to work, completely absorbing from the gastrointestinal tract. When taking a hungry stomach, absorbed better. In the case of drug intake after eating, its digestibility is only 70%.

The time of the maximum content in the blood of each component of amoxiclava is 875 its. So amoxicillin reaches its apogee after about two hours, while his companion is a little earlier, after 1.25. The half-life is about both about an hour.

And amoxicillin, and clavulanic acid without problems are distributed in the body, penetrating all organs and liquid medium. With absence inflammatory processes in brain sheath Do not pass through the hematostephalic barrier.

Both are capable of bringing into breast milk, without problems penetrate and through the placenta.

Up to a quarter of amoxicillin comes through the kidneys in the form of penicilloic acid. Clawulanic acid is actively decayed, is partially excreted in part with urins, partly through the gastrointestinal tract, partly with exhaled air.

To a greater degree, the drug goes through the kidneys, but clavulanic acid is also derived from the off-show mechanism.

With kidney violations, the rate of removal of substances decreases in proportion to a decrease in the renal function.

If you violate the liver function, it is necessary to use carefully, while constantly controlling the liver operation.

Purpose

Exceptionally infectious diseases.

Amoxiclav 875 - Instructions for use

Rules for taking medication

The dosage of amoxiclava is selected individually for each case in

dependence on the severity of illness, weight, patient age, general status His body.

But this dosage is usually prescribed only with severe forms of the disease.

General. It stands before meals, this will lead to the optimal distribution of active substances in the body, reducing the risk of side effects.

Infections occurring in light and medium severity are treated as follows: twice a day at 875 mg.

In the case of existing kidney disorders, the adjustment of one-time techniques should only be with a loan to Creatine clearance. The maximum dosage of 875 mg can be prescribed only at a value of\u003e 30 ml / min. In other cases, it must be lower dosages represented by other medicines.

With the available liver disorders, amoxyclave is taken with great caution, constantly controlling the liver operation.

Overdose

May appear the following symptoms: Failures in the work of the gastrointestinal tract, as a result of amoxicillin intake, crystalluria may develop. The appearance of convulsion at renal failure or having a big dosage.

At the fact of an overdose, a doctor's consultation is necessary, symptomatic treatment is carried out. The stomach washing makes sense if no more than four hours have passed since the procedure. To do this, drink as much water as possible and independently cause vomiting, pressing the root of the language. After washing, adsorbents are required, activated carbon is suitable.

Contraindications

1. It is impossible to prescribe amoxiclav in sensitivity to any component, intolerance penicillin antibiotics, cephalosporins and other beta-lactam.
2. Hepatitis A, infectious form of mononucleosis and lympholecosis.
3. Babies up to 12 years old or with a weight below 40 kg drug is also contraindicated.
4. Amokisklaw is prescribed with caution under the existing deviations in the work of the gastrointestinal tract, liver failure, during breastfeeding and combined with anticoagulants.

Side effects

Most often, unwanted reactions are manifested in the gastrointestinal tract - stomach disorder, liquid chair, vomiting. This reaction can be avoided if you drink a tablet before eating. Sometimes antibiotic-associated colitis, stomatitis can appear.

There are also cases of increasing the activity of Alaninotransferase. Extremely rare cases of cholestatic jaundice, hepatitis. Such deviations occur more often in men and the elderly. Children had no such reactions.

Deviations can manifest themselves in the process of treatment or after its completion and can be treated.

• Extremely rare, but allergic reactions in the form of edema or anaphylactic shock are likely;
• In rare cases, dizziness, cramps, urticaria, sleep disorders were noted;
• Often I celebrate the manifestations of the candidiasis.

At the first manifestations adverse Reactions It is necessary to stop taking the drug and consult a doctor.

Interaction

Laxative, glucosamine and antacids can affect the absorption of amoxiclava, slowing down this process. Ascorbic acid, on the contrary, speeds up this action.

A diuretic, allopurinol, phenylbutazone, as well as NSAIDs capable of blocking the tubular secretion, increase the content of amoxicillin.

The complex reception of amoxiclava and probelexide is able to increase the level of amoxicillin. Amoxiclav in the methotrexate complex increases the toxicity of the latter, so this combination is not recommended.

Tandem with allopurinol can cause skin itch, redness.

Combined with rifampicin is likely to reduce antibacterial action. It is also not suitable for simultaneous intake with bacteriostatic antibiotics due to the probability of reducing the effectiveness of amoxiclava. For the same reasons, it is necessary to refuse from sulfanimamides.

Allopurinol phenylbutazone probencid rifampicin

Amoxiclav is capable of minimizing the effectiveness of oral contraceptives.

Analogs

This list can be continued for a long time. All these drugs are distinguished by the manufacturer, some differences in the dosage of the active substances contained in them and the form of release. There are small differences in contraindications.

The price range is also different. So amoxiclav 875 in the pharmacies of Russia can be purchased on average at a price of 450 rubles.

special instructions

To reduce the risk of unnecessary phenomena from the busty, amoxiclav should be taken exclusively during the meal.

Against the background of treatment, there is a possibility of the development of superinfection, but if there are bacteria in the body, insensitive to these active substances.

Upon the occurrence of mononucleosis of infectious genesis, it should be selected a more appropriate drug from analogs.

At the first signs of antibiotic-associated colitis, it is necessary to immediately discontinue treatment.

Urine analysis can reflect the incorrect parameters for the presence of glucose in Urin.

In the event of dizziness, cramps and other deviations in the central nervous system, it is better to abandon the CNS.

Alcohol when receiving amoxiclava is not contraindicated, but doctors are still recommended to abandon any kind of alcoholic beverages during antibiotic treatment.

Amoxiclav 875 125. Reviews

Alina: Last year, a daughter from children's camp He arrived with a runny nose, which very quickly converts into a dry cough, then the temperature came. From antibiotics, the doctor prescribed amoxiclav. Typically, in such situations, Flexin Soluteab was prescribed. I was surprised, but the doctor explained that amoxiclav the newer Flexin and he had a larger spectrum of action. I did not argue, but the pills really helped us very well.

Marina: I rarely sick, and so to drink antibiotics, this is the edge. But several times had to treat her husband from a tightening cold. The doctor prescribed Amoxiclav every time. Without sides, we did not cost, my husband had a weak stomach, so even Linex did not smooth the situation. But the disease very quickly retreated. Another husband did not like that the pills are large enough, it is not very convenient to take. And the rest were satisfied, really quickly and efficiently.

Vyacheslav: Last spring grabbed me angina. It often happens to me and every time purulent, long. All this is rushing, smearing, well, without antibiotics, it also does not do. I do not mind trying new medicines, but when I was prescribed Amoxyclav, doubted, it was expensive, it was a little expensive, almost 500 rubles per 14 pieces. But bought. So, already two days later, almost there is almost no trace from my angina. The temperature went away, the flare on the larynx passed. By the end of the week already completely recovered.

Amoxiclav - antibacterial drug penicillin group. it complex A new generation with powerful antimicrobial activity regarding most pathogenic bacteria. Due to this, the medicine has an extensive scope of use, and is successfully used to treat many diseases. Read further about Amoxiclava, the forms of its release, from which it helps, side effects and contraindications.

Composition and action

Maintenance active substances - amoxicillin and clavulanic acid. The combination of these active substances ensures the pronounced therapeutic effect of the antibiotic. Thanks to clavulanic acid, amoxiclav can be assigned in infections resistant to amoxicillin.

The antibacterial drug has a pronounced bactericidal and bacteriostatic action for almost all types of streptococci (the exception is meticillin-resistant strains), sheets, echinococci. Sensitive to the drug and gram-negative bacteria: Klebseyella, Brucella, Moraxella, Salmonella, Gardnernella, Protoney, Clostridium and others.

The maximum antibiotic concentration is achieved after 1 hour after receiving the drug. Active substances, regardless of the introduction method, are rapidly distributed in the tissues and body fluids (middle ear, lungs, uterus, ovaries, peritoneal and pleural liquids, fat and muscle tissues, nasal sinuses, almonds, and so on).

The drug is excreted from the body through the kidneys (half-life during healthy kidneys - 1-1.5 hours). A small amount of Clavulanic acid metabolites is highlighted with exhaled air and cartoons.

Medicine does not penetrate through the shell of the brain and spinal fluidThis feature significantly reduces the risk of unpleasant adverse reactions from the CNS.

Forms of release

• Amoxiclav tablets - 250 mm amoxicillin / 125 milligrams of clavulanic acid, 500 milligrams / 125 milligrams and 875 milligrams / 125 milligrams, respectively;
• tablets Amoxiclav Kviktab - 500 milligrams / 125 milligrams, 875 milligrams / 125 milligrams, dispersed pills;
• Amoxiclav for parenteral administration - powder for the preparation of a solution for administration to Vienna 600 milligrams (500 milligrams of amoxicillin and 100 milligrams of clavulanic acid) or 1.2 grams in a bottle (1000 milligrams of amoxicillin and 200 milligrams of clavulanic acid);
• powder for preparing the suspension - 125 milligrams of amoxicillin and 31.25 milligrams of clavulanic acid per 5 milliliters and 250 milligrams of amoxicillin and 62.5 milligrams of clavulanic acid per 5 milliliters.

Indications for use

• ENT infections and infectious diseases of the upper respiratory tract (cap abscess, pharyngitis, scarletin, medium otitis, tonsillitis, sinusitis, chronic and sharp sinusitis, laryngitis, tracheit, angina).
• Infectilation of the lower respiratory tract (bronchitis chronic and acute, pneumonia).
• Biliary tract infections (cholangitis, cholecystitis).
• Infection urinary tract (cystitis, prostatitis, pyelonephritis, urethritis and others).
• Gynecological diseases of infectious origin (adnexitis, inflammation of appendages, endometritis and others).
• Ondogenic infections, including periodontitis.
• Venereological infections (syphilis, ureaplasm, gonorrhea, including provoked by gonococci).
• Shankroid.
• Infections of soft tissues and skin cover, including wound infections (furunculosis and so on).
• Infections of joints and bones.
• Orthopedic practice.
• Infections of the lymphatic system (lymphadenitis and others).
• Mixed infections caused by gram-negative and gram-positive microorganisms, anaerobic pathogens (missile abscess, mastitis, postoperative abdominal infections, aspiration pneumonia).

Also amoxiclav is used in dentistry (with flux, stomatitis, and so on) and for the prevention of purulent-septic complications in surgical interventions on organs abdominal cavity, small pelvis, kidneys, bile dursesHeart muscle.

How to use

The exact metering mode is set by a physician individually depending on the severity of the disease and therapeutic effect. The duration of treatment with an antibiotic ranges from 5 to 14 days.

Pills

Take inside immediately before meal, swallowed by integer, not chewing and drinking water.

According to the instructions, adults and children with body weight above 40 kilograms in pathologies of easy and middle severity Assign 1 tablet (250 milligrams / 125 milligrams) every 8 hours (3 times a day) or 1 tablet (500/125 milligrams) every 12 hours (2 times a day); In case of severe, the disease is prescribed - 1 tablet 500 milligrams / 125 milligrams every 8 hours (three times a day) or 1 tablet 875 milligrams / 125 milligrams every 12 hours (twice a day).

Tablets Amoxiclav Kviktab

Before use, the tablet must be dissolved in 100-150 milliliters of water and stir well. Adults and children from 12 years old are prescribed 1 tablet (500 milligrams / 125 milligrams) 2-3 times a day; for heavy conditions - 1 tablet (875 milligrams / 125 milligrams) twice a day.

Powder for parenteral use

To prepare a solution for intravenous administration, the contents of the bottle are dissolved in water for injection (for amoxiclava 600 milligrams - 10 milliliters; for amoxiclava 1.2 grams - 20 milliliters). Next, the resulting solution is administered intravenously slowly for 4-5 minutes.

If the medication needs to be introduced in the form of intravenous infusion, then 600 milligrams of drugs are dissolved in 10 milliliters of water for injections and add it to an infusion solution (50 milliliters). The antibiotic 1.2 grams is dissolved in 20 milliliters of water for injections and added to 100 milliliters of the infusion solution. Dripping drug is injected for 30-40 minutes. Does freeze funds.

Suspension

Bottle with powder Shake well, add warm boiled water (up to the label) in 2 clips, every time scattering until the powder is completely dissolved.

In pediatrics, newborn and infants up to 3 months prescribe a medicine at the rate of 30 milligrams per 1 kilogram of weight (daily dose), this quantity should be divided and given in 2 receptions at equal intervals.

From 3 months, the antibiotic is prescribed at a dose at the rate of 25 milligrams per 1 kilogram of body weight, it is also divided into 2 receptions. For infectious diseases Middle gravity is prescribed by 20 milligram per 1 kilogram of body weight and divide it for 3 administration. In severe conditions, the dose increases - 45 milligrams per 1 kilogram of weight and divide it into 2 introductions per day.

Contraindications

• Lympholoicosis;
• infectious mononucleosis;
• cholestatic jaundice or hepatitis, resulting from the reception of antibacterial drugs of a group of penicillins;
• hypersensitivity to antibiotics of a group of cephalosporins, penicillins and other beta-lactam drugs;
• increased sensitivity to clavulanic acid or amoxicillin.

With caution, the medicine is prescribed with severe disorders of the renal function, renal failure and patients with pseudommabranous colitis in an anamnesis.

Side effects

• Allergic reactions: urticaria, itching, erythematous rash; In rare cases - angioedema edema, allergic vasculitis, anaphylactic shock, Stevens-Johnson syndrome, exfoliative dermatitis.
• From the digestive tract: Possible nausea, loss of appetite, diarrhea, vomiting; seldom - painfulness in the abdomen area, liver function disorders; In isolated cases, hepatitis, cholestatic jaundice can develop, pseudomembranous colitis.
• From side nervous system : Headache, dizziness; Rarely - hyperactivity, insomnia, anxiety, convulsions (may be observed in patients with impaired kidney function when using medication in high doses).
• From the hematopoietic system: rare cases of reversible leukopenia (including neutropenia), thrombocytopenia; In isolated cases develops hemolytic anemia, Pancitopenia, eosinophilia, reversible increase in prothrombin time (while using anticoagulants).
• From the urinary system: Rarely - crystalluria, interstitial jade.
• Others: Candidiasis.

During pregnancy

Antibacterial drug is not recommended to apply during pregnancy. Exceptions are cases where the benefits of treatment above are potentially harm to the fetus. Reception of amoxiclava during pregnancy increases the risk of developing necrotic colitis in newborns.

Undesirable to take the drug and lactation, since clavulanic acid and amoxicillin in small quantities stands out from breast milk. If the mother still prescribed treatment with medicine, it is worth canceting breastfeeding for a while. Otherwise, the child may appear diarrhea, allergic reactions, and so on.

For kids

Children under 12 years and weighing less than 40 kilograms are prescribed an antibiotic in the form of a suspension. Recommended dosages are indicated above.

With alcohol

During medicine therapy is prohibited to use alcoholic beverages. Acceptance of alcohol significantly reduces the antibacterial effect of the drug and makes it difficult to eliminate through the kidneys.

Analogs

Substitutes for the active substance: amuoviclin, artlet, augmentin, amoxicillin + clavulanic acid, Bakoklav, Verklav, Claus, Liklav, Medoclaw, Panklaw, Ranclav, Rapiklav, Tomerentine, Flemoclav Solutab, Ecoclav.

Analogs of the mechanism of action:

Amoxicillin (Amoxicillin Sandoz, Amosin, Ecobol, Ranoxyl)

Release form - tablets, capsules, injection powder, suspension; Active substance - amoxicillin.

Bactericidal antibacterial preparation from a group of semi-synthetic penicillins. It has wide spectrum Actions and used for the treatment of bacterial infections: pneumonia, bronchitis, angina, urethritis, pyelonephritis, gonorrhea and other microorganisms caused by sensitive medicine.

The dosage is selected individually. For adults inwards and children from 12 years old (or with a weight of more than 40 kilograms), 250-500 milligram are prescribed, with severe course diseases - up to 1 gram; Children 5-10 years old - 250 milligrams; 2-5 years - 125 milligrams; Up to 2 years, the daily dose is 20 milligrams per kilogram of weight. There should be at least 8 hours between medication techniques. Children under 12 are recommended to use amoxicillin in the form of a suspension.

In parenteral use, adults intramuscularly introduced 1 gram twice a day; Children - 50 milligrams / kilogram / day, one-time - 500 milligrams, multiplicity of administration - 2 times a day.

Side effects: Erythema, Sweet Sweep, conjunctivitis, anaphyactic shock, joint pain, feverish state.

Contraindications: Hypersensitivity to penicillins, infectious mononucleosis. With caution, the antibiotic is prescribed by pregnant and patients prone to allergic reactions.

Ampioks (Oxampicin, Oxep)

Release form - capsules, powder for making a solution; Active substances - ampicillin sodium, oxacillin sodium.

The antibacterial drug refers to semi-synthetic penicillins and shows activity relative to gram-negative (meningococcus, intestinal wand, gonococcus, salmonella and so on) and gram-positive (streptococcus, pneumococcus, staphylococcus) microorganisms. Indications for use are: tonsillitis, pyelonephritis, sinusitis, tonsillitis, pneumonia, medium otitis, meningitis, cystitis, cervicitis, and so on.

Capsules are taken in front of food, swallowing entirely and drinking water. Adults and adolescents from 14 years are prescribed at 0.5-1.0 grams (2-4 capsules); 7-14 years old - 50 milligrams / kilogram / day; 3-7 years old - 100 milligrams / kilograms / day; The daily dose is divided by 4-6 receptions. The duration of treatment is 7-14 days.

Intravenously and intramuscularly (drip, inkjino) The daily dose for adults and adolescents from 14 years is 3-6 grams; children 7-14 years old - 100 milligrams / kilogram / day; 1-6 years old - 100 milligrams / kilogram / day; Newborn, premature and kids up to 1 year - 100-200milligrams / kilogram / day. The daily must be administered in 3-4 receptions, with an interval of 6-8 hours. According to dose indications can be increased 1.5-2 times.

Side effects: rhinitis, skin cover hyperemia, arthralgia, conjunctivitis, vomiting, diarrhea, nausea, leukopenia, enterocolitis, anemia, angioedema swelling.

Contraindications: lympholecosis, infectious mononucleosis, hypersensitivity. Use with caution when chronic insufficiency, in children who were born in mothers with the intolerance of penicillins.

Ampisid (Sulsin, Sulacillin, Libac Cyllain, Ampicillin + Sulbaktam, Sulbacin)

Release form - powder, pills; Active substances - ampicillin, sulbactam.

The combined antibiotic group of penicillins is prescribed to patients of all age groups in infectious diseases caused by ampicillin and sulbactam sensitive and microorganisms. Among them are infections: respiratory organs (pleurrites, bronchitis, bacterial pneumonia), ENT organs (otitis, sinusitis, tonsillites), urinary and sexual organs (cystitis, pyelonephritis, adnexites, and so on), gastrointestinal bodies (cholangitis, pancreatitis, cholecystitis ), musculoskeletal system (mositeitis, arthritis, osteomyelitis), leather and subcutaneous fiber (burn wounds, grinding inflammation, infected dermatoses), prevention of postoperative infections.

Tablets are prescribed inside before taking food, in 1-2 hours in a daily dose of 375-750 milligrams for adults and 25-50 milligrams per kilogram of body weight for children, whose weight does not exceed 30 kilograms. Daily dose of medication must be divided into 2 receptions.

Intramuscularly and intravenously (drip at a speed of 60-80 drops per minute, stove - slowly, for 3-4 minutes). It is intravenously introduced 5-7 days if you need to continue treatment, then go to intramuscular use. With an easy course of infection with adults - 1.5-3 grams per day in 2 administration; with an average course - 3-6 grams per day in 3-4 administration; Heavy current - 12 grams per day in 3-4 administration. For children, the daily dose is taken at the rate of 150 milligram per 1 kilogram of weight, the multiplicity of administration is 3-4 times; Newborn and premature babies - every 12 hours. Duration of therapy 5-14 days.

Side effects: Reducing appetite, nausea, vomiting, diarrhea, anemia, leukopenia, drowsiness, headache, skin hyperemia, urticaria, rhinitis, eosinophilia, candidiasis (long-term use).

Contraindications: Lactation period, infectious mononucleosis, hypersensitivity. With caution in hepatic and / or renal failure, pregnancy.

Clonak-H.

Release form - capsules; Active substances - amoxicillin trihydrate, Cloxacillin sodium.

The drug is active in respect of most gram-positive and gram-negative bacteria. It is assigned in the infections of the upper respiratory tract, pneumonia, bronchitis, the infections of the gastrointestinal tract, the blade, the skin and soft tissues, gonorrhea, and so on.

Capsules are taken before eating, drinking water, swallowing entirely, not chewing. Adults are prescribed 1 capsule every 6-8 hours, depending on the severity of the disease. If the kidney function is violated, the dose is reduced.

Side effects: nausea, diarrhea, skin rashes, in rare cases can develop pseudommbranous colitis (intestinal colic).

Contraindications: childhood, pregnancy, lactation period, infectious mononucleosis, hypersensitivity to active substances. With caution to take patients with allergic reactions.

Tazocin (Tazrobida, Piper Cyllain + Tazobaktam Teva)

Release form - lyophilisate for solution; Active substances - Piperotillalin, Tazobactam.

Bactericidal semi-synthetic antibacterial drug of a wide range of action is effective in infections of medium-heavy and heavy flow: bacterial infections of the lower and upper respiratory tract, abdominal organs, complicated and uncomplicated pathology of the skin and soft tissues, abscess, small pelvis organs, bacterial septicemia (blood infection by bacteria), Infections of joints and bones.

The drug is injected intravenously drip (slowly for 30 minutes) or intramuscularly. The daily dose in adults and adolescents from 12 years with a normal kidney function is 2.25 grams every 6 hours or 4.5 grams every 8 hours; Children 2-12 years old - 90 milligram per 1 kilogram weight every 6 hours. For patients passing hemodialysis (blood purification method), the maximum dose is 2.25 grams every 8 hours. The duration of therapy is 7-10 days.

Side effects: vomiting, nausea, development of intestinal colic, itching, urticaria, rash, erythema, headache, cramps, hypoglycemia, phlebitis, hypotension, blood tides to the skin of the face, an increase in body temperature, rarely - arthralgia and others.

Contraindications: Hypersensitivity, age up to 2 years. With caution with strong bleeding (in history), pregnancy, lactation, fibrosis, hypokalemia, pseudo-membrane enterocolite.

Timenin

Release form - lyophilisate for the preparation of the solution; Active substances - ticarcillin, clavulanic acid.

The antibiotic has a wide range of action and is shown for the treatment of infections of connective and bone tissue, in gynecology, leather and subcutaneous fiber, urinary tract, and so on.

The drug is administered intravenously drip or stroke. Intervals between infusions should be at least 4 hours. Therapy needs to continue for 48-72 hours after the symptoms disappear.

Adults and adolescents with weight of more than 40 kilograms The average dose is 3 grams every 6 hours or 5 grams every 8 hours. Maximum dose - 3 grams every 4 hours. Children with weight of less than 40 kilograms are prescribed 75 milligrams / kilograms every 8 hours (maximum - 75 milligrams every 6 hours); Premature babies with weight of less than 2 kilograms - 75 milligrams every 12 hours, with weight of more than 2 kilograms - 75 milligrams every 8 hours. With violations of the kidney function, the dose is adjusted.

Side effects: diarrhea, nausea, vomiting, hepatitis, cholestatic jaundice, convulsions, leukopenia, reduction of hemoglobin levels, eosinophilia, urticaria, rash, itching, anaphylactic reactions, redness of the skin, a feeling of burning and so on.

Contraindications: premature children with impaired kidney function, hypersensitivity to active substances, pregnancy, lactation.

Amoxiclav is a modern antibacterial agent of a group of penicillin, which has a wide range of action. Contains amoxicillin antibiotic and clavulanic acid, reinforcing its action. Today it is considered the most effective tool treatment of infectious diseases in patients of different age groups.

Is it possible to use amoxiclav 250 mg tablets for children, their instructions for use that says about this? What dosage forms are for small patients? What testimony and contraindications has a drug? Let's talk about this in detail on the site "Popular about health":

Medicinal forms for kids

Immediately note that amoxiclav in tablets according to the instructions is not intended for the treatment of children under 12 years. For small patients, the drug is produced in the form of a suspension. The packaging of the suspension contains a bottle with a powder, which is divorced by boiled water immediately before use. For ease of use, a measuring pipette and a plastic spoon is attached to the vial.

From which the drug helps?

This antibiotic is prescribed with various infectious diseases of bacterial nature.

In particular, it is used in the treatment of respiratory system infections, such as: bronchitis, infectious angins, etc.

Also, the medicine is used in infectious pathologies of connective, as well as bone tissues, dontogenic infections (complications of diseases oral cavity), treat infections from animal bites.

Prescribe to eliminate infections bladder, digestive tract, kidneys and skin (except allergic manifestations).

In combination with other drugs, amoxiclave can be prescribed in the treatment of gonorrhea, lesteriosis, mucous lesions. Includes therapy of the acute flow of gastritis and ulcerative disease.

Dosage for children and use method

For small patients, the dosage is calculated not only in mind the age, but also body weight.

Powder for the suspension can be represented in a dosage of 125 and 250 mg. As for the finished suspension of 250 mg, 5 ml of the drug contains 250 mg of antibiotic and 62.5 mg of clavulanic acid.
Application tablets. Also, children over 12 years old and weighing more than 40 kg are prescribed 1 tablet every 8 hours.

The dosing mode of a suspension of 250 mg children during treatment is determined as follows:

Newborn and kids up to 3 months -30 mg / kg body weight. This volume is divided into 2 receptions per day (the dosage is calculated by one portion of amoxicillin). The required amount of powder is bred by boiled water. Give a baby with a pipette that is applied to the bottle.

Children over 3 months - 20 mg / kg weight. In severe infectious diseases, for example, pneumonia, increase to 40 mg / kg.

Age Body weight (kg) Suspension 250 mg

3-12 months 5 - 10 1.25 ml
1-2 years 10 -12 2 ml
2-4 years 12 -15 2.5 ml
4 - 6 years 15 - 20 3 ml
6-10 years 20 -30 4.5 ml
10 - 12 years 30 - 40 6.5 ml

The daily dosage used for children cannot be exceeded more than 40 mg of antibiotic per 1 kg body weight. Even if the treatment of severe disease is carried out. The entire amount of medication appointed by a child doctor is divided into 2-3 receptions (before meals), with intervals of 8-12 hours.

It is necessary to remember that the optimal dosing regimen and the duration of treatment should determine the attending physician, taking into account the severity of infection, age, patient weight and other factors.

Preparation of suspension

Before cooking, shake the bottle with powder vigorously. Next, 85 ml of water should be addressed, but in two stages. Shake the contents every time. When calculating dosage, consider that a measuring spoon and pipette attached to the drug are calculated on 5 ml drug.

You can keep the prepared suspension in the refrigerator, but not more than a week. Before each application, it is necessary to break the contents of the bottle.

For a better understanding of the method of cooking suspension and use the drug, carefully read the liner. Instructions Amoxiclav to use accurately describes all these moments.

Contraindications

This drug should not be used in the severe course of diseases of the digestive tract, with severe stages of the pathologies of biliary organs, as well as in pronounced disorders of the liver functions, which are caused by the intake of amoxicillin and / or clavulanic acid.

It is better to choose a different drug if there is an individual intolerance to amoxiclav components or there is an increased sensitivity to penicillins, as well as cephalosporins and other beta-lactam antibiotics.

There are contraindications for receiving if infectious mononucleosisor lympholecosis.

With caution prescribe a suspension of amoxiclav children with allergic diathesis, as well as suffering bronchial asthma, hay fever.

The simultaneous use of 250 mg of the drug with a metronidazole is contraindicated to patients with impaired hematopopic functions, having diseases of the nervous system, as well as during leukemia of lymph.

When treating this drug, it should be remembered that amoxiclav, like any other antibiotics, suppresses the intestinal microflora. Long use can provoke the development of dysbacteriosis, disruption of digestion and painful feelings in the epigastric area. In addition, the drug prevents the synthesis of vitamin K.

Therefore, in addition to the prescribed treatment, the doctor may assign taking vitamins and probiotics.

In conclusion, it should be noted that amoxiclav, although it has a wide range of applications, but it is unsafe independently. This is especially true for children. It is necessary to have complete confidence that the disease is caused precisely bacterial infection, not other pathogen. It is known that the use of antibiotics with viral or fungal lesion, at best, is useless, at worst - can cause serious harm.

In addition, you need to remember that contraindications this drug, just like other antibacterial agents, much more than indications for use.
Such drugs can cause allergies, have other side effects. Therefore, for children (as well as adults), this medicine should be prescribed only a qualified doctor, after the diagnosis and detection of the pathogen.

Antibiotic Amoxiclav 1000 is a drug effectively against microbes with a large spectrum against the mass of the types of bacteria. It includes an ampicillin derivative (or amoxicillin) + clavulanic acid. Functions of the latter - the cessation of penicillin enzymetyivation by means of contact with bacterial beta lactamases.

The composition of amoxiclava 1000 mg

Amoxiclav 1000Stoms from the following substances:

Active:

• Amoxicillin (in the form of trihydrate) - 875 mg;
• Clawulanic acid (in the form of clavinatacal) - 125 mg.

Auxiliary:

• Crospovidon;
• Silicon dioxide;
• Magnesium stearate;
• Talc;
• Cellulose in microcrystals;
• Sodium cross-camera.

The film shell consists of the following: titanium dioxide, macrogol 6000, diethyl phthalate, hypimosellos, ethyl cellulose.

Amoxiclav 1000 is well absorbed into the blood regardless of the time of meals. The greatest concentration in the blood is created in an hour the field of use of this medication. Traditionally, the course of treatment lasts from 5 to 10 days. For longer than two weeks, this drug is impossible to take this drug without appointing a doctor.

What does the number 1000 mean in the title of this drug? This means that the composition of one tablet includes 875 mg of antibiotic (amoxicillin) and 125 mg of clavulanic acid. There will be a thousand mg or 1 grams in the amount.

Indications for use

• Otitis;
• Tonsillitis;
• Chronical bronchitis;
• Acute bronchitis;
• Abscesses;
• Skin inflammation caused by animal bites;
• Urinary tract diseases;
• Postpartum sepsis;
• Infected abortion;
• Pelvioperitonitis;
• Edometritis;
• STD (sexually transmitted diseases);
• For the prevention of infections during operations.

Efficiency Amoxiclav 1000 mg against microbes

From which aerobes (microbes) is effective amoxiclav 1000 mg:

• Gram-positive (enterococci, staphylococci, streptococci);
• Gram-negative (Escherichia, Klebsiella, Moraxella, hemophilic stick, Gonokokk, Shigella, Meningokok).

Amoxiclav 1000 mg tablets are not effective against the following microbes:

• Singny wand;
• Intracellular pathogens (chlamydia, mycoplasma, legionella);
• Methicillically resistant staphylococci;
• Bacteria: Enterobacter, acitobacter, serration.

There are conditions of the body, in which the pills amoxyclav 1000 cannot be:

This medicine is not prescribed by those who diagnosed creatinine clearance less than 30 ml per minute, children under the age of 12, patients with phenylketonuria. Caution, under the permanent observation of the doctor, you should use such a medicine and pregnant women, and even more so - Mama with impaired kidney work, during breastfeeding period. With caution, assign it to those who are diagnosed with hepatic insufficiency.

By-effect

Judging by clinical Studies and reviews about amoxiclav 1000 mg, its use can lead to such negative consequences:

• Thrush of the oral cavity;
• Thrush of the vagina;
• Disorder of intestinal microflora;
• Rash on the skin;
• Allergic vasculitis;
• Pseudomambranous colitis;
• Medicinal hepatitis;
• Cholestatic jaundice (mainly in elderly patients).

All listed above manifests itself extremely rare, it is not a regularity, but an exception. Level up biochemical analysis The blood comes back to normal after the discharge of the drug for seven days.

Many side Effectsespecially those associated with gastrointestinal tract, You can avoid, taking simultaneously with the Linex antibiotic described by us (live bacteria) or other probiotics.

Analogues of pills Amoxiclav 1000 mg

Amoxiclava analogs of 1000 mg:

• Abiklav;
• Augmentin;
• Bortoklav;
• Betaklave;
• Claws;
• Clawamitin;
• Clamox;
• Panklav;
• NOVAKLAV;
• Repeiklav;
• Therakslav;
• Flemoclav;
• Sumamed.

The cost of amoxiclava 1000 and its analogues

The amount of amoxiclava 1000mg is approximately 440-480 rubles per pack, consisting of two blisters, in each of which 7 tablets. This cost is due to Swiss production and related to this transport costs. The amoxiclav of German production will cost approximately 650 rubles. Domestic analogues are cheaper, but not much, the same Augmentin 1000 mg will cost approximately 300 rubles. Such is the cost of this antibiotic.

Interaction with other medicines

Medicines that block the tubular secretion increase the concentration of amoxicillin. With simultaneous reception of amoxiclava M glucosamine and antacids, laxatives, suction slows down. If at the same time drink amoxiclav and ascorbic acid, suction, on the contrary, will accelerate.