A drug Albendazole -anthelmintic. Albendazole affects the polymerization of β-tubulin, stops it. As a result, there is a violation of the formation of microtubules in the intestine of helminths, the ability of worms are suppressed to absorb glucose, the normal intracellular migration of organelle is blocked, the synthesis of ATP in their muscle tissue is blocked. The creation of therapeutic concentration of albendalosis leads to the death of helminths.
Active with respect to adult individuals and larval forms. The drug causes death nematodes (Necator americanus, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Cutaneous Larva Migrans, Ancylostoma duodenale), cestodes (porcine, bovine and dwarf tapeworms), trematodes (Clonorchis sinensis, Opisthorchis viverrini), protozoa (Giardia ).

Indications for use

Albendazole.prescribe with: neurocystserical; Echinococcosis of peritoneum, liver, lungs; Contraindications to the operation with a cissy echinacocoma; the need for surgical intervention during cystic echinacocoma to reduce the amount of cyst; Arachnoidal, intragastric, racing cysts; Ascaridose; trichonese; enterobiosis; Ankylosomidosa; opisthorchose; giardiasis; microsporidosis; toxocarcosis; ratostomosis; trichinosis; capillary; Mixed helminthosis.

Mode of application

Assign Albendazole.internally, after eating. Tablets wash with water. The table shows dosages depending on the pathology. Reception of laxatives after receiving albendazole is not needed.

Side effects

Reception Albendazola.may be accompanied by side effects: leukopenia, pancytopenia, headache; thrombocytopenia; aggralocytosis; dyspepsia; an increase in liver transaminase activity; abdominal pain; dizziness; meningal symptoms; skin item; hyperthermia;
urticaria; alopecia (reversible); hypertension; Disruption of the kidney function.

Contraindications

:
Contraindica Albendazole.with: gelminths in children under 2 years old; hypersensitivity to albendazole; pregnancy; lactation.
With caution when: retinal pathologies against the background of cysticercosis; cirrhosis of the liver; Infertility of bone marrowing.

Pregnancy

:
Categorically contraindicated Albendazole.during pregnancy, suspected pregnancy.

Interaction with other medicines

Plasma concentration Albendazola. Increase the prazicvantel, dexamethasone, cimetidine.

Overdose

:
With overdose of the drug Albendazole. Characterized by the strengthening of adverse symptoms.

Storage conditions

Storage Albendazola.produced under standard conditions (low room humidity, room temperature). Storage time Albendazole tablets ¬- 3 years.

Form release

Release Albendazole.in tablets - 0.4 mg; 3 Tab. / Packaging.

Structure

:
1 Tablet Albendazola.contains Albendazole 0.4 g. Auxiliary components: starch, sodium starchhamalglicol, sodium dodecylsulfate, gelatin, poverant, methylparaben, propylparaben, talc, silicon dioxide, magnesium stearate, Opadry II WHITE.

Additionally

:
When developing leukopenia Albendazole.cancel.
The activity of hepatic enzymes control every two weeks of therapy. When exceeding the indicators, half the drug is canceled.
Before therapy of neurocystserkosis, retinal pathologies are excluded.
Pregnancy test in front of anthelmiath therapy Albendazole needs women reproductive age.

In the treatment of helminthosis, Albendazole preparation is often prescribed.

What is a drug

The drug is named the name of the main component - Albendazole. In pharmacies, when buying Albendazole, pharmacists may offer to acquire nemonas. This is an analogue preparation active substance, not different from him. As for analogues in action, it is possible to name the drug furnacesol.

The drug is universal. It is actively used for children and adults, the solution is used in veterinary medicine for the treatment of cattle, as well as there are tablets for dogs and other pets.

Indications for use

Indication to the reception of albendazole is the contamination of opistores

Probability of development side Effects It always depends only on the competent preparation of the treatment regimen. It is for this reason that the therapy should be performed only under the supervision of a doctor. Self use drug Treatment It is not recommended for any person or an animal.

According to the instructions for use, the albandazole may be assigned in the following cases:

• the presence of echinococcal cyst;
• identification of intactors;
• the presence of neurocystserkosis;
• diagnosed strondhyloidosis;
• infection with helminths, namely ascarides, toxocaras, Giardia, Ankilosters, and so on.

Albendazole is also used to treat neurocystserkosis

IMPORTANT: uncontrolled intake means can provoke a mass of negative consequences in humans.

Features of application

Since the treatment diagram may differ in each case, the doctor should be engaged in its choice

Treatment of children

• Neurocystserocosis requires the prescription of the suspension at the rate of 150 mg / 10 kg of weight. Therapy continues at least eight days. In the event that after laboratory diagnostics The signs of improvement are not noted, the course should be repeated.

Albendazole can be applied to the treatment of a child who has reached 2 years

• Anquityidomy, as well as ascariasis and enterobiosis are eliminated by one-time. The dose in this case is 200 mg. Quite often, the suspension is prescribed again after three weeks.
• Strongiloidosis requires the appointment of the drug for three days of 200 mg. The same scheme is used under cue.

And other diseases arising from the defeat of parasites. Albendazole was designed in 1975 and enters the main list medicines "World Health Organization." The medicine is designed to receive inside.

Operating principle

High efficiency is achieved against nematodes and cest. The tool is used as with poly and monoinvazy.

The drug reduces cysts or completely destroys them in patients suffering from granular echinococcosis. The research results prove that the number of non-visual cystic becomes more than 90% after receiving the means, if compared with a similar indicator in patients who did not undergo treatment.

Pharmacokinetics

It is recommended to take a drug with food, especially fat, which helps to increase absorption from the gastrointestinal tract. The small part turns into albandazole sulfoxide, which is a primary metabolite. It also has anthelmintic activity. The drug is almost completely distributed through the body. It falls into the urine, liver, bile, spinal fluid. Primary metabolite turns into albendazole sulfon, as well as other oxidation products.

The highest level of blood concentration is observed approximately 2-5 hours after reception. Albendazole is excreted mainly with a biliary in the form of a primary metabolite. There is a removal of a small amount with urine.

Indications for use

Albendazole is used to treat the following diseases:

• (defeat);
• trichocephalace (infection);
• askaridoza;
• microsporidiasis;
• giardiasis;
• filiariosis;
• neurocystserkosis (ZNS infection);
• mixed gelminths.

The medicine is used everywhere, including the CIS countries. In Africa, it is used for the treatment of lymphatic filyriosis, as well as for the purpose of prevention to stop infection. In this region, Albendazole is used in combination with.

Dosage

The number and duration of the reception depends on the type of helminthosis, the degree of invasion, age and body weight.

For people

The daily dose for a person is established with its weight.

Neurocystserikosis and echinococcosis

With neurocysticosis and echinococcosis, patients with a body weight, not exceeding 60 kg, use 15 mg of means per 1 kg of weight. There are enough two techniques per day. Patients with a body weight exceeding 60 kg, take 400 mg twice a day. The therapeutic course of echinococcosis - 3 cycles for 28 days each. Between them should withstand the gap in two weeks. Neurocystsericcosis therapy is carried out from 8 to 30 days.

For the treatment of neurocystserkosis, except albendazole, it is necessary to take anticonvulsant drugs, if there is a need for this. In the first days of therapy, intravenous or oral corticosteroids can be appointed.

Askaridoz, Trichocephalosis, Enterobiosis and Ankylosomidosis

When ascariasis, tricocephalosis, enterobiosis and anquosomidosis Patients with weight of more than 20 kg are taken by 400 mg of medication once. If there is a need, the reception is repeated after 2-3 weeks. For children with a weight of up to 20 kg, 200 mg of the drug is enough.

Filiariatus

With filariasis, albendazole is used 400 mg twice a day. Patients take the drug in such a dosage for 10 days.

Enterkolit

With enterocolite use 400 mg of medication once. In case of toxocamism, the drug is used in a dosage of 400 mg 2 times a day. The therapeutic course is 5 days.

Some doctors consider the optimal conducting therapy of toxocaroz for 20 days.

Strondhyloidosis

With strondhyloidosis, 400 mg of medication is used twice a day during the week. In trichinelosis, the same dosage is used, only the course of therapy is from 8 to 14 days. For tricocephalosis therapy, 400 mg is prescribed 1 time per day for 3 days.

Hepatic lobster

Contraindications

The drug is not recommended for patients whose body manifests hypersensitivity to its components. Albandozol should not be taken during pregnancy and during lactation. Children up to 2 years are assigned to caution and only in extreme cases.

There is no less than two weeks between treatment courses, otherwise unwanted consequences are possible.

Side effects

Albendazole is able to cause dizziness, fever symptoms, nausea, vomiting, short-term hair loss, abdominal pain. Sometimes there are resistant throat pains, convulsions, problems with vision, yellowing eye apples or skin cuts, darkest urine, worried painful feelings In the stomach, the mood changes. Allergic reactions are possible. A single cases of acute hepatic insufficiency are recorded after taking medication.

Unwanted effects after using Albendazole include leukopenia, pancytopenia, agranulocytosis, dyspepsia, meningial symptomatomy, itching on the skin, disruption of the kidneys.

Interaction with other means

The means of carbamazepine, phenytoin and phenobarbital reduce the level of concentration of albandazole in plasma, as well as half-life. Cimetidine increases the whey concentrations of the drug, increases the half-life. This contributes more high efficiency Albendazole, which is necessary in severe cases of diseases.

Trade names and cost

The trade names of Albendazole are "Neason", "Zentel", "Gelmadol", "Sanoksal", "Aldazol", "Wormil". All these drugs are synonyms, i.e. contain the same actants.

Albendazole based preparations are produced in the form of tablets (including chewing for children), suspension, capsules. The average cost varies within 3-4 dollars. But it is very dependent on the country in which the drug is sold. At the same time, the same albandazole preparation can cost at times more expensive in the neighboring country.

Prices comparison for analogues

Tradename	Price, dol.				Features
	Russia	Ukraine	Belarus	Kazakhstan
Neasonal	2,4-3	8	1.53- 2.22	from 5.	Production - India (Inca Laboratories). Nezolol is the most popular in Russia among other analogues of Albendazole. In Ukraine, the price is overestimated.
Wormil	-**	from 1.05	—	—	Production - India (Windlas Helker). It is not for sale in Russia. Ukraine is very affordable in terms of cost. Also available in the form of phytosyrope
Zentel	—	from 1.2.	2.53- 2.77	from 3,55.	Production - South Africa (GlaxosmithKline).
Sanoksal	from 2.8.	from 10.	—	—	Manufacturer - India (Protech Biosystems).
Aldazol.	—	from 0.53.	1,1-1,7	—	Manufacturer - Ukraine (Kiev vitamin plant). Ukraine is the cheapest among other analogues due to local production.
Gelmadol.	—	—	2,05-3,17	from 4.8.	Manufacturer - Ukraine (WORLD MEDICINE).

* - Prices are per dose, and not for packaging (sometimes it contains more). If possible, the cost of the drug in the form of tablets or capsules was taken, while the suspension can cost cheaper.
** - The drug is not registered in a given country, practically absent on sale or failed to clarify.

Analogs

Albendazole refers to a group of benzimidazols. Therefore, the main analogue for people are and. Other gashelmint agents from this group (, oxfendazole) are used only in veterinary medicine, as they have greater toxicity.

Albendazole - Antihelmintic wide spectrum actions.

Release form and composition

The drug is produced in the form of round white tablets. They are packaged in cell packs of 3 pcs, which are placed in cardboard packs along with the instructions. Each tablet contains:

• albendazole (400 mg);
• potato starch;
• starchmalglick sodium;
• sodium dodecyl sulfate;
• gelatin;
• methylparaben;
• silicon dioxide anhydrous;
• calcium stearate;
• povidone.

Pharmacological properties

Pharmacodynamics

The active ingredient has the following effects:

To Albendazole, the most susceptible:

• echinococci;
• pork chain;
• giardia;
• interested intestinal.

Pharmacokinetics

Indications for use

Indications for use are:

• neurocystirocosis associated with the active life of the pork chain larvae;
• echinococcal lesion of the liver, respiratory organs, abdominal wall, caused by the spread of the larvae of a dog ribbon worm;
• nematodose (contamination by ascarides, sharp, vlasmallas, ease of intestinal, feline duct);
• infections caused by the simplest microorganisms (microsporidiasis, giardiasis);
• mixed glider invasions;
• echinococcal cysts (the drug is applied before and after the operational removal of the neoplasms);
• toxocamia.

Contraindications

Preparation is contraindicated in allergic reactions Albendazole and additional ingredients in tablets. Relative contraindications include:

1. Brain lesion cysts of a pork chain. Children under 2 years old give 15 mg / kg per day. Daily dose for patients weighing more than 40 kg - 400 mg. It is necessary to be treated at least 8 days. In the absence of the result, the therapeutic course is repeated.
2. Enterobiosis, ascaridosis, anquosomidosis. 200 mg of albendazole is administered orally once. To eliminate re-infection, the same dose of the drug is accepted after 21 days.
3. Cestodosis and strondhyloidosis. Children under 2 years of 200 mg of Albendazole per day are given within 3 days. In the absence of effectiveness, treatment is repeated after 3 weeks. Adults take 1 tablet (0.4 g).
4. Giardiasis. Recommended daily dose - 400 mg. It is necessary to be treated at least 3 days.

Albandazole side effects 400

When conducting anthelminth therapy, albendazoles may arise such negative effects as:

• neurological diseases (pain in the frontal and occipital regions, violation of the vestibular apparatus, signs of lesion of the cerebral cortex);
• gastrointestinal disorders (pain and feeling of gravity in the right side, bouts of nausea and vomiting, changing the functioning of the liver);
• allergic symptoms (redness and itching of the skin, pseudo-allergic reactions, angioedema edema);
• other side effects (change in blood composition, feverish syndrome, renal failure, hair loss, high sweating, arterial hypertension, rapid heartbeat, asthenic syndrome).

Overdose

Excess prescribed doses increases the likelihood of digestive damage nervous systems. In the first hours after taking the drug, the purification of the stomach and the reception of enterosorbents is effective. Subsequent therapy has a supportive and symptomatic nature.

Special instructions of Albendazole 400

In the treatment of patients suffering from liver pathologies, regular control of the organ work is required. With long therapy, it is necessary to monitor changes in the qualitative and quantitative composition of the blood. With a sharp drop of leukocyte levels, the drug is canceled.

Application during pregnancy and lactation

Childcare

Medicinal interaction

Prazikvantel slows down the removal of albendazole, which can contribute to the development of heavy side effects. When used in conjunction with cimetidine, the toxicity of the latter increases.

Terms and conditions of storage

Tablets are stored at room temperature without disturbing the integrity of the contour packages. The drug can be used for 3 years from the date of production.

Conditions of vacation from pharmacies

A recipe is required to buy an antexless.

Price

3 Albendazole Tablets will cost 130 rubles.

Analogs

• Sanoksal;
• Nemonol;
• Gelmodol-vm.

Strong anthelmint drug nemsol.

Instructions for use

Nezolov Instructions for use

Dosage form

Chewable tablets from white to almost white, oval, capsule, double-screw, with risky on one side.

Structure

Albendazole 400 mg

Auxiliary substances: starch corn, sodium lauryl sulfate, povedone-30, methylparaben, propylparaben, citric acid, gelatin, talc peeled, sodium starch glycolat, silicon colloidal dioxide, magnesium stearate, aspartame, pineapple flavoring, mint aroma.

Pharmacodynamics

Antihelmintic drug. The main mechanism of action is associated with an inhibitory effect on the polymerization of beta tubulin, which leads to the destruction of cytoplasmic microcanallers of cells intestinal tract helminths; Changes the flow of biochemical processes (suppresses glucose utilization), blocks the movement of secretory granules and other organel in muscle cells round worms, Conducting their death. The most active in relation to the larval forms of cestode - Echinococcus Granulosus and Taenia Solium, nematode - Strongyloides Stercolatis.

Pharmacokinetics

Suction and distribution

After taking inside, it is poorly absorbed from the gastrointestinal tract, unchanged form is not determined in the blood plasma. Bioavailability when taking low, about 30%. Reception simultaneously with fatty food increases the absorption and the value of Cmax in the blood plasma 5 times.

Metabolism and elimination

Albendazole is quickly biotransformed in the liver into the primary metabolite - albendazole sulfoxide, which also has antiform activity. Cmax albendazole sulfoxide in blood plasma is achieved in the range from 2 to 5 hours, binding to plasma proteins - 70%. Albendazole sulfoxide is almost completely distributed in the body; It is found in the urine, bile, liver, in the wall of cysts and cystic fluid, the spinal fluid.

Albendazole Sulfoxide in the liver turns into albendazole sulfon (secondary metabolite) and other oxidized products. T1 / 2 albandazole sulfoxide - 8-12 hours. Is excreted in the form of various metabolites with urine.

Pharmacokinetics in special clinical cases

The removal of albendazole and its main metabolite does not change when the kidney function is violated.

In patients with impaired liver function, bioavailability increases, Cmax albendazole sulfoxide in the blood plasma increases by 2 times, T1 / 2 is extended. Albendazole is the inductor of the microsomal enzymes of the cytochrome R450 system; Accelerates the metabolism of many drugs

Side effects

From side digestive system: Violation of the liver function with a change in functional hepatic tests (weak or moderate increase in transaminase activity), pain in the abdomen, nausea, vomiting.

From the side of the blood formation system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, pancytopenia.

From the CNS: headache, dizziness, meningeal symptoms.

Dermatological reactions: reversible alopecia, skin rash, itching.

Others: Income increase, increase blood pressure, acute renal failure, allergic reactions.

Features of sale

prescription

Special conditions

In neurocysticosis, appropriate GCS and anticonvulsant drugs should be carried out. GCS for intake or in / in administration is used to prevent hypertensive attack in the first week of antibistrate therapy.

Control laboratory indicators

Blood tests must be carried out at the beginning of each 28-day cycle every 2 weeks during the period of therapy by albendazole. Continue treatment with albendazole is possible if the reduction in the total content of leukocytes and neutrophilic leukocytes is moderate and does not progress.

Indications

Nematodose (ascariasis, enterobiosis, ankylosomidosis, intercators, tricocephalosis);

Mixed glider invasions;

Strondhyloidosis;

Neurocystirocosis caused by the larval form of Taenia Solium;

Echinococcosis of the liver, lungs, peritoneum caused by the larva shape of Echinococcus Granulosus;

Giardiasis;

Toxocamia;

As auxiliary means surgical treatment Echinococomic cyst.

Contraindications

Retina damage;

Pregnancy;

Increased sensitivity to components of the drug and other benzimidazole derivatives.

Caution is used in violation of blood formation, disorders of the liver function (before and during treatment should be regularly monitored by the function of the liver), during breastfeeding period.

Medicinal interaction

For sharing Albendazole dexamethasone and cimetidine increase the concentration of albandazole sulfoxide in the blood.

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Mode of application

Dosage

The average therapeutic dose in the treatment of nematodoses for adults and children over 2 years old is 400 mg or 20 ml of suspension inside one.

The drug is accepted during meals. It is recommended to carry out the simultaneous treatment of all family members.

With neurocysticosis and echinococcosis patients with a mass of body 60 kg and more drug are prescribed 400 mg 2; With a mass of body less than 60 kg, the dose is set at the rate of 15 mg / kg / in 2 reception. Maximum daily dose - 800 mg (400 mg 2). Neurocysticosis treatment rate - 8-30 days; With echinococcosis - 3 cycles for 28 days with a 14-day interval between cycles.

With lamblios, the drug is prescribed at the rate of 10-15 mg / kg 1 time / within 5-7 days.

In case of toxocamism, adults and children over 14 years old with a body weight of more than 60 kg are prescribed 400 mg 2; with a mass of body less than 60 kg - 200 mg 2; For children under 14, the dose is set at the rate of 10 mg / kg 2 the duration of therapy 7-14 days.

Overdose

Treatment: stomach wash, activated carbon. If necessary, spend symptomatic therapy.