One tablet contains: active substance: nitrofurantoin 50 mg or 100 mg; Excipients: potato starch, anhydrous colloidal silicon dioxide, calcium stearate.

Pharmacotherapeutic group

Antibacterial agents for systemic use. Nitrofuran derivatives.
ATX code: J01XE01.

Pharmacological properties"type =" checkbox ">

Pharmacological properties

Pharmacodynamics
Synthetic antimicrobial agent wide range actions. It has a bactericidal effect.
The mechanism of action is associated with the restoration of furadonin into an active intermediate, which damages ribosomal proteins, disrupts the synthesis of protein, DNA, RNA. In high doses, it disrupts the permeability of the bacterial cell membrane.
Active against gram-positive aerobic bacteria: Staphylococcus spp., Streptococcus spp.; gram-negative aerobic bacteria: Escherichia coli, Enterobacter spp., Klebsiella spp., Shigella spp. Weakly active in relation to Enterococcus spp., fungi of the genus Candida... Not active in relation Pseudomonas aeruginosa, Acinetobacter spp.
Most strains Proteus and Serratia resistant to furadonin.
Pharmacokinetics
Furadonin is well absorbed in the upper sections gastrointestinal tract and is rapidly excreted in the urine. The half-life is about 30 minutes. The maximum excretion in the urine occurs 2-4 hours after taking furadonin, the proportion of unchanged drug is about 40-45%.

Indications for use

Uncomplicated infections urinary tract(cystitis, urethritis, pyelitis) caused by sensitive microorganisms;
- prevention of infections during urological operations and examinations (cystoscopy, catheterization).

Contraindications

Hypersensitivity to nitrofurantoin or nitrofurans;
- severe renal dysfunction, renal failure, oliguria (creatine clearance less than 60 ml / min);
- children under 6 years of age, pregnancy, and the period of lactation due to possible hemolytic anemia in the fetus or newborn due to the immaturity of the enzyme systems of erythrocytes;
- cirrhosis of the liver, chronic hepatitis;
- chronic heart failure (NYHA class III-IV);
- deficiency of glucose-6-phosphate dehydrogenase;
- acute porphyria.

Method of administration and dosage

Administered orally during meals with plenty of water.
Adult patients
Acute uncomplicated urinary tract infections: 50 mg four times daily for seven days. Severe re-infection: 100 mg four times a day for seven days.
Long-term maintenance therapy: 50-100 mg once a day.
Prevention: 50 mg four times a day for urological operations and examinations and 3 days after them.
Children over 6 years old
Acute uncomplicated urinary tract infections: 3 mg / kg / day in four divided doses for seven days. Maintenance therapy: 1 mg / kg once a day.
For children weighing less than 25 kg, the use of the drug in the form of a suspension is recommended.

Precautionary measures

The drug should be discontinued at the first signs of peripheral neuropathy (the occurrence of paresthesias), because the development of this complication can be life-threatening.
It is necessary to discontinue treatment with furadonin if unexplained symptoms of impaired lung function, liver function, hematological and neurological disorders occur.
If signs of lung damage appear, furadonin should be discontinued immediately. Careful monitoring of lung function is required in patients receiving long-term treatment with furadonin, especially in the elderly.
Careful monitoring of patients receiving long-term furadonin therapy is required in order to identify signs of hepatitis development.
After taking furadonin, urine may turn yellow or brown. In patients receiving furadonin, false-positive reactions may occur when determining glucose in urine.
Furadonin should be discontinued if signs of hemolysis appear in patients with suspected glucose-6-phosphate dehydrogenase deficiency.
Reactions from the gastrointestinal tract can be minimized when the drug is taken with food, milk, or when the dose is reduced.
With prolonged therapy, it is possible to develop superinfection caused by fungi or insensitive microorganisms.
Nitrofurantoin should be used with caution in case of impaired renal function (creatinine clearance 60–90 ml / min), suspicion of a deficiency of glucose-6-phosphate dehydrogenase or other erythrocyte enzymes, in debilitated patients, those with allergies, liver and lung pathology, neurological disorders.

Pregnancy and lactation

The use of furadonin during pregnancy is contraindicated. If it is necessary to use it during lactation, the child should be weaned from the breast for the entire period of treatment.

Use in pediatrics

Caution in prescribing

Should be observed in persons with diabetes mellitus, anemia, electrolyte disturbances, deficiency of B vitamins; possible enhancement of neuro toxic action drug.

Should not be applied

For the treatment of diseases of the renal cortex (glomerulonephritis), purulent paranephritis, prostatitis. Especially for the treatment of parenchymal infection of one non-functioning kidney. In the case of recurrent or severe infection, surgical causes must be ruled out.

Impact on the ability to drive vehicles and work with moving machinery

Furadonin may cause dizziness and drowsiness. The patient should not drive a car or work with moving machinery while taking the medication.

Side effect

From the gastrointestinal tract: nausea, vomiting, lack of appetite, abdominal pain, diarrhea, pancreatitis, pseudomembranous colitis.
From the liver and biliary tract: cholestatic jaundice, cholestatic syndrome, chronic active hepatitis (sometimes fatal, usually with prolonged therapy). If symptoms of hepatotoxicity appear, the drug should be discontinued.
From the side nervous system: headache, drowsiness, dizziness, depression, euphoria, nystagmus, confusion, psychotic reactions, intracranial hypertension... In rare cases, severe or even irreversible peripheral neuropathy (including optic nerve) with symptoms of sensory and motor disorders. With the above symptoms, the drug should be discontinued.
From the respiratory system: acute pulmonary reactions (usually develop within the first week of treatment and are reversible after discontinuation of the drug) are characterized by sudden onset of fever, eosinophilia, cough, chest pain, shortness of breath, pulmonary infiltration, pleural effusion.
Chronic pulmonary reactions are rare, in patients who received long-term therapy for 6 months or more, more often in elderly patients. The severity depends on the duration of treatment after the first clinical symptoms... Changes in the ECG associated with pulmonary reactions may occur, rarely - cyanosis, collapse. The impairment of lung function may be irreversible.
When the first signs of a disturbance from the respiratory system appear, the drug should be discontinued.
On the part of the skin and subcutaneous tissue: hypersensitivity reactions - skin rashes, maculopapular rash, urticaria, itching in some cases: angioedema, anaphylaxis, inflammation of the salivary glands, eczema, exfoliative dermatitis, erythema multiforme (including Stevens-Johnson syndrome), lupus-like syndrome.
From the hematopoietic and lymphatic systems: leukopenia, granulocytopenia or agranulocytosis, thrombocytopenia, megaloblastic anemia, aplastic anemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency.
From the musculoskeletal system: arthralgia.
Others: reversible alopecia, superinfection (usually caused by Pseudomonas aeruginosa or fungi), dark yellow or brown urine staining.

Content

With inflammation Bladder, urethritis doctors prescribe Furadonin - the instructions for use of the drug contain information about its penetration into the blood, the side effects of nitrofurantoin and the principle of its action. Only a urologist or a therapist can prescribe a medication, you cannot buy it on your own. Read the instructions for use of the medicinal product.

Furadonin medicine

Tablets for cystitis Furadonin, according to pharmacological classification, are included in the group of antimicrobial and bactericidal drugs. The medicine has a wide range of properties, has proven itself as an element of therapy infectious diseases urinary tract. In pharmacies, several forms of drug release are presented, which have a similar effect, but differ in the appointment according to the patient's age.

Composition and form of release

The active ingredient of the drug is nitrofurantoin, which belongs to the group of nitrofurans. Check out detailed composition all formats of the medicinal product:

Shape / Feature	Pills	Enteric-coated tablets		Suspension
Concentration of nitrofurantoin	50 or 100 mg per 1 pc.	0.03 g per 1 pc.	1 g per pack	Indicated on the pack
Additional substances	Potato starch, calcium stearate, aerosil (colloidal silicon dioxide), stearic acid, polysborbate-80			Similar ingredients plus water
Description	Yellow or greenish tablets, flat cylindrical shape		Yellow powder	Yellow solution, precipitation is allowed
Packing with instructions	12, 20, 30, 40 or 50 pieces in a contour non-cell or cellular pack	30 pieces per pack	5 or 10 g in a polyethylene bag	The package contains a measuring cup or spoon

Pharmacological properties

Furadonin is an antimicrobial agent broad action, a nitrofuran derivative, but not included in the group of antibiotics. Due to the active substance, the drug has a bactericidal and bacteriostatic effect in urinary tract infections. The medicine destroys the membranes of bacteria, inhibits protein synthesis, destroys Escherichia coli, Klebsiella, Enterobacteriaceae, Proteus, Staphylococcus aureus. The agent is well absorbed by the digestive tract, its bioavailability increases with food intake.

According to these instructions, the rate of absorption of the antibacterial agent depends on the size of the crystals (the powder dissolves faster, is absorbed, and concentrates in the urine as quickly as possible). The substance binds to plasma proteins by 60%, is metabolized by the liver and muscle tissues, the half-life is 20-25 minutes. Nitrofurantoin crosses the placental and blood-brain barriers and is excreted by the kidneys.

Indications for use

According to the instructions, the medicine Furadonin has the following indications for use:

• infectious and inflammatory diseases of the urinary organs;
• pyelonephritis, acute cystitis, pyelitis, urethritis, asymptomatic bacteriuria, paranephritis;
• uncomplicated bladder infections;
• for the prevention of infections during urological operations and preparation for them (cystoscopy, catheterization urinary tract).

How to take Furadonin

The medicine has a bitter taste, therefore it is not recommended to chew the tablets. The suspension bottle must be shaken well before use, then measure the nitrofurantoin dose with a glass or spoon. The suspension is allowed to be combined with milk, water, juice - this reduces discomfort in the stomach. According to the instructions, Furadonin tablets for pyelonephritis should be taken with plenty of water... The effect of nitrofurantoin is enhanced in an acidic environment, so it is recommended to consume more protein foods.

Pills

The recommended dose for adults is 50-100 mg, 4 times / day. The maximum dosage is 600 mg / day, single dose is 300 mg. The course of treatment lasts seven days, it is possible to continue therapy for another three days, provided that the urine reaction was monitored for sterility. After long-term treatment, the dose of the drug is gradually reduced. Supportive therapy includes 50-100 mg tablets once a day, for prevention it is recommended to take 50 mg four times a day for operations for urological diseases and the same dose three days after.

Suspension

According to the instructions, children are recommended to take the medicine in the form of a suspension. Dosage synthetic the drug is calculated based on the weight of the child - 5-8 mg of the drug is taken per kg of body weight. The received daily amount of the drug is divided into four doses. The duration of suspension therapy is a week. After that, the doctor analyzes the urine for sterility, makes a culture for the presence of microorganisms and, if necessary, prescribes an appointment for another three days.

Powder

The form of the medicine in the form of a powder is rarely used, it dissolves in a liquid and is taken with cystitis. Furadonin is prescribed in the amount of 50-100 mg four times / day for adults, the course of treatment is 7-10 days. The maintenance dose for urological infections is considered to be 50-100 mg 1 time per day (it is better to take it at night). This dosage is used to prevent exacerbations or when chronic course illness. Supportive therapy can last all year round, with a minimum duration of three months.

special instructions

The instructions for use of Furadonin list special instructions you should know before taking the drug:

• In patients with anemia, diabetes mellitus, electrolyte imbalance, renal failure and group B vitamin deficiency, the risk of developing peripheral neuropathy increases.
• The medication is not used to treat purulent paranephritis, diseases of the renal cortex, parenchymal infection of one inoperative kidney and prostatitis.
• According to reviews, Furadonin can cause drowsiness and dizziness, therefore it is not recommended to take it while driving or dangerous machinery.
• While taking the drug, more yellow urine may be observed, this phenomenon is reversible, it goes away on its own after stopping the treatment of infections.

During lactation and pregnancy

The period of gestation and breastfeeding is a contraindication for the use of the medication. This is due to the increased risk of hemolytic anemia in the baby. The active substance of the drug crosses the placenta, causing a toxic effect on the fetus. If the benefit to the mother outweighs the risk to the child, the doctor may prescribe Furadonin, but only after the first trimester. The active ingredient penetrates into breast milk, therefore, for the duration of treatment, it is necessary to postpone breast-feeding.

For children

The suspension is contraindicated in children under the age of one month, Furadonin tablets are prescribed from the age of six. The indication for use is the therapy of urinary tract infections. Furadonin for children is prescribed in the following dosage:

• 5-7 mg / kg body weight per day;
• after 12 years - 100 mg twice a day;
• therapy lasts 5-7 days;
• with uncomplicated acute infections urinary tract - 3 mg / kg / day in 4 divided doses for seven days;
• maintenance therapy - 1 mg / kg once a day;
• with a body weight of up to 25 kg, a suspension is shown.

Drug interactions

Instructions for the use of Furadonin have a section drug interactions of this drug with other medicines:

• Combination with nalidixic acid, an antacid containing magnesium trisilicate, reduces the antibacterial effect of nitrofurantoin.
• Do not use the drug with fluoroquinolones.
• Medicines that block the secretion of the tubules reduce the antibacterial activity, the concentration of nitrofurantoin in the urine and increase the toxicity of its content in the blood.
• Drugs that increase urine pH reduce the activity of Furadonin.
• Sulfinpyrazone and probenecid reduce drug excretion.
• It is forbidden to drink alcohol during Furadonin therapy.

Side effects

To the negative effects arising from the use of the drug, in the instructions for use the following symptoms are attributed:

• cough, shortness of breath, chest pains, seizures bronchial asthma;
• fibrosis, pneumonia, anorexia;
• nausea, vomiting, diarrhea, hepatitis, jaundice;
• headaches, drowsiness, neuropathy;
• reversible anemia, urticaria, itchy skin, rash, allergic reactions;
• dermatitis, erythema;
• cholestatic syndrome;
• fever, superinfection.

Overdose

Symptoms of an overdose with Furadonin tablets in the instructions for its use include nausea and vomiting. You can eliminate the signs by dialysis. To remove the toxic effect of the main substance of the drug and increase the rate of its elimination from the body, doctors prescribe patients to take a large amount of liquid. Gastric lavage and antihistamines are also effective in treating overdose.

Contraindications

According to the instructions, the use of Furadonin is prohibited in the presence of the following contraindications:

• disorders of renal excretory function;
• renal and heart failure;
• pregnancy, lactation;
• pathology of the glomerular zone of the kidneys;
• glomerulonephritis;
• age up to a month;
• oliguria;
• hypersensitivity to components;
• cirrhosis of the liver;
• acute porphyria;
• chronic hepatitis.

Terms of sale and storage

The drug is dispensed from pharmacies with a doctor's prescription. Stored away from light, moisture, at temperatures up to 25 degrees, out of the reach of children. The shelf life is four years.

Analogs

Complete analogue of the drug in composition and active active substance no, but there are medicines on sale that are similar in pharmacological action. These are tablets, capsules, suspensions, powders and solutions of domestic and foreign production:

• Furadonin Avexima;
• Furadonin Lect;
• Nifuroxazide-lf;
• Nifuroxazide-Rn;
• Furagin;
• Furamag.

Furadonin's price

You can buy the drug through pharmacies or the Internet. When buying, you must present a prescription from a doctor. The cost of the medication depends on the selected format, manufacturer and the established markup level in the pharmacy. Approximate prices:

A kind of medicine	Manufacturer	Price when buying via the Internet, rubles	Price when buying through a pharmacy, rubles
Tablets 100 mg 20 pcs.	Olainfarm, Latvia
50 mg 20 Pcs.
50 mg 20 Pcs.	Irbitsky KhFZ, Russia
50 mg 10 Pcs.
50 mg 20 Pcs.	Borisov plant

Video

The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

The drug Furadonin

Furadonin- antimicrobial synthetic remedy, which has a wide spectrum of action.

Furadonin is not an antibiotic, it belongs to the group of drugs of the nitrofuran series. On many bacteria - Klebsiella, Staphylococcus, Enterococcus, Escherichia coli, Proteus, Enterobacter, etc. - the drug has a bacteriostatic (stops the reproduction of microbes) and bactericidal ("kills" microbes) action.

Furadonin is used to treat urinary tract infections.

The drug is well absorbed from the gastrointestinal tract, crosses the placenta and into breast milk, cerebrospinal fluid, excreted by the kidneys. May darken urine. The concentration in the blood at usual therapeutic doses is negligible.

The active ingredient of the medicinal product is nitrofurantoin.

Forms of issue

• Tablets 0.05 g, 20 pieces per package.
• Tablets 0.1 g, 20 pieces per package.
• Tablets 0.03 g, soluble in the intestine, 30 pieces per package (for children).
• Suspension Furadonin (for dosing, a measuring cup or spoon is included in the package).

Instructions for the use of Furadonin

Indications for use

Furadonin is used for the treatment and prevention of infectious and inflammatory diseases of the urinary tract (caused by pathogens sensitive to the drug):

• cystitis;
• pyelitis;
• pyelocystitis;
• pyelonephritis;

WITH preventive purpose Furadonin is prescribed for cystoscopy (examination of the bladder using an optical cystoscope device), catheterization of the bladder (insertion of a special rubber tube into the bladder - a catheter), during urological operations.

Contraindications

• Individual intolerance to nitrofurantoin;
• renal failure with severe impairment of renal excretory function;
• chronic active hepatitis or cirrhosis of the liver;
• heart failure II-III degree;
• lack of B vitamins;
• pregnancy and breastfeeding;
• early childhood: up to 1 month;
• acute porphyria (hereditary disease with damage to the nervous system);
• purulent inflammation of the perineal tissue.

Furadonin is not prescribed for the treatment of glomerulonephritis. With caution (since the appointment increases the risk of complications - peripheral neuropathies), Furadonin is used for such diseases and conditions:

• violations electrolyte balance;
• lack of B vitamins;
• genetic (congenital) deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• anemia (anemia).

Furadonin should not be prescribed concurrently with Nevigramon - this reduces the effectiveness of Furadonin. Also not recommended joint application Furadonin with drugs that cause impaired renal function.

Side effects

• Allergic reactions: urticaria, Quincke's edema (diffuse or limited swelling of the subcutaneous fat), itchy skin; in very rare cases - anaphylactic shock (life-threatening severe allergic reaction organism).
• From the respiratory system: cough, shortness of breath, chest pain; interstitial pneumonitis (inflammation of the lung tissue with damage to the alveolar wall) or fibrosis (replacement of lung tissue connective tissue); decreased lung capacity; asthmatic attack in patients with bronchial asthma.
• From the digestive system: decreased appetite, discomfort in the epigastric region, nausea, vomiting; in rare cases - hepatitis (inflammation of the liver); cholestatic jaundice (violation of the outflow of bile); abdominal pain, diarrhea.
• From the nervous system: headaches, drowsiness, dizziness, nystagmus (involuntary oscillatory rhythmic movements eyeballs), peripheral neuropathy (degenerative damage to peripheral nerves).
• From the side of the hematopoietic organs: a decrease in the number of white blood cells (white blood cells), a decrease in the number of platelets (platelets involved in blood clotting), a decrease or complete absence of granulocytes (a type of white blood cells involved in defensive reactions organism), hemolytic anemia (anemia due to the destruction of red blood cells - red blood cells), megaloblastic anemia (malignant anemia with vitamin B 12 deficiency) - these adverse reactions are reversible.
• From the side of the skin: exfoliative dermatitis (inflammation of the skin with detachment of the surface layer), erythema multiforme (a disease of the skin and mucous membranes of an infectious-allergic nature).
• Other options for side effects: superinfection of the urinary tract (an inflammatory process caused by another pathogen - more often Pseudomonas aeruginosa); arthralgia (joint pain); drug fever; chills, bone aches; weight loss ; tinnitus; itching and vaginal discharge.

Furadonin treatment

How to take Furadonin?

Furadonin has a bitter taste. The tablets should not be chewed; they need to be washed down with plenty of water (at least 1 glass).

The suspension bottle must be shaken well before use, then the required dose of the medicine must be measured. The suspension can be mixed with milk, water or fruit juice.

Taking Furadonin with food or milk can reduce stomach and intestinal discomfort.

The action of Furadonin is enhanced in an acidic environment, therefore, the use of protein products is recommended in the diet.

During treatment with Furadonin, nalidixic acid and antacids (drugs that reduce the acidity of gastric juice), which include magnesium trisilicate, should not be taken. at the same time, the absorption of Furadonin and its therapeutic effect are reduced.

It is undesirable to use simultaneously Sulfinpyrazone and Probenecid - they help to reduce the excretion of Furadonin in the urine. And this will cause an increase in the concentration of Furadonin in the blood, an increase in its toxicity and a decrease in the therapeutic effect in the urinary tract.

Furadonin dosage
The dose of Furadonin is determined by the doctor. Usually, adults are prescribed 50-100 mg 4 times a day. The course of treatment lasts 5-8 days, if necessary, the doctor can extend the course of treatment up to 10 days.

In the absence of a therapeutic effect, a longer intake of the drug is inappropriate.

Prophylactic, anti-relapse treatment can last 3-12 months. Daily dose is determined at the rate of 1-2 mg per 1 kg of patient weight. The prophylactic dose can be taken once a day, before bedtime.

Furadonin for children

In pediatrics, for the treatment of urinary tract infections, Furadonin can be prescribed to children over 1 month of age.

The dose of the drug is determined at the rate of 5-7 mg per 1 kg of body weight per day. The daily dose is divided into 4 doses.

Children over 12 years of age are prescribed 100 mg 2 times a day. The course of treatment is 5-7 days.

Furadonin during pregnancy

Given the fact that Furadonin crosses the placenta and can have a toxic effect on the fetus, it is contraindicated to take it during pregnancy.

Experimental studies in animals have identified a risk to the fetus. The clinical experience of using Furadonin during pregnancy has not been studied.

Gynecologists sometimes use Furadonin to treat urinary tract infections in women after 12 weeks of pregnancy. In this case, it is necessary to compare possible risk for the fetus and healing effect from the use of Furadonin.

Furadonin for cystitis

Furadonin is used to treat acute and chronic cystitis (inflammation of the bladder) in both adults and children (over 1 month old).

It is advisable to conduct a bacteriological examination of urine (urine culture) before starting treatment to identify the pathogen that caused cystitis and determine the sensitivity of the isolated microorganism to antibacterial agents (including Furadonin). In chronic cystitis, such an examination must be carried out with each exacerbation, because and pathogen inflammatory process and its sensitivity to antibacterial agents may vary.

The dosage of Furadonin for cystitis is usual: 50-100 mg 4 times a day. Duration of treatment is 7-10 days. Children are prescribed a dose of 5-8 mg per 1 kg of body weight.

The maintenance dose (or prophylactic to prevent exacerbations) in chronic cystitis is 50-100 mg of Furadonin 1 time per day (can be taken at night). The duration of maintenance therapy is determined by the doctor. The treatment can be carried out for 3-12 months.

Furadonin's analogs

Furadonin has no structural analogs (synonyms).

Analogues on the mechanism of therapeutic action (nitrofuran derivatives):

• Furamag;
• Furazidine;
• Furagin;
• Furasol.

Furagin or Furadonin?

Furadonin and Furagin are antimicrobial drugs from the same group (nitrofuran derivatives). The mechanism of action and indications for these drugs are similar. In some cases, Furagin is more effective.

Both of these drugs have almost the same side effects. But in Furagin they are somewhat less pronounced, it is a milder drug in comparison with Furadonin.

Currently, in the treatment of urinary tract infections, more modern medicines(Norbactin, Nolitsin, etc.). Either way the choice medicinal product performed by a doctor.

In this article, you can read the instructions for the use of the medicinal product. Furadonin... Reviews of website visitors - consumers of this medicine, as well as opinions of doctors of specialists on the use of Furadonin in their practice are presented. A big request is to actively add your reviews about the drug: did the medicine help or did not help get rid of the disease, what complications were observed and side effects, possibly not declared by the manufacturer in the annotation. Furadonin's analogs in the presence of available structural analogs. Use for the treatment of cystitis and pyelonephritis in adults, children, as well as during pregnancy and lactation.

Furadonin- a broad-spectrum antimicrobial agent, a nitrofuran derivative. It has a bacteriostatic and bactericidal effect in urinary tract infections. Nitrofurantoin (active ingredient of the drug Furadonin) is active against Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.

It is mainly effective for urinary tract infections.

Pharmacokinetics

Well absorbed from the gastrointestinal tract. Bioavailability is 50% (food increases bioavailability). Metabolized in the liver and muscle tissue. Penetrates the blood-brain barrier, placental barrier, excreted with breast milk... It is excreted completely by the kidneys (30-50% - unchanged).

Indications

• infectious and inflammatory diseases of the urinary tract (including pyelonephritis, cystitis) caused by microorganisms sensitive to nitrofurantoin.

Forms of issue

Tablets 50 mg and 100 mg.

Instructions for use and dosage

The dose for adults is 50-100 mg, the frequency of use is 4 times a day. The daily dose for children is 5-7 mg / kg in 4 divided doses. The duration of the course of treatment is 7 days. If necessary, it is possible to continue treatment for another 3 days (only after urine control for sterility). During long-term maintenance treatment, the dose of nitrofurantoin should be reduced.

Side effect

• pain in chest;
• cough;
• dyspnea;
• pulmonary infiltrates;
• an attack of bronchial asthma in patients with a history of asthma;
• a feeling of discomfort in the epigastrium;
• anorexia;
• nausea, vomiting;
• stomach ache;
• diarrhea;
• peripheral neuropathy;
• headache;
• dizziness;
• drowsiness;
• leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible);
• hives;
• Quincke's edema;
• itchy skin;
• rash;
• anaphylactic shock (very rare);
• drug fever;
• arthralgia;
• possible flu-like symptoms;
• superinfection of the genitourinary tract, often caused by Pseudomonas aeruginosa.

Contraindications

• severe disorders of renal excretory function;
• renal failure;
• oliguria;
• insufficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• early childhood (up to 1 month);
• hypersensitivity to nitrofurantoin;
• heart failure stage 2-3;
• cirrhosis of the liver;
• chronic hepatitis;
• acute porphyria;
• lactation.

Application during pregnancy and lactation

Furadonin is contraindicated for use during pregnancy and lactation (breastfeeding).

special instructions

The risk of developing peripheral neuropathy increases in patients with anemia, diabetes mellitus, electrolyte imbalance, deficiency of B vitamins, severe renal failure.

Furadonin should not be used to treat diseases of the renal cortex, with purulent paranephritis and prostatitis. Nitrofurantoin is not prescribed in combination with drugs, causing violations kidney function.

Drug interactions

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of Furadonin.

Nitrofurantoin is incompatible with fluoroquinolones.

With the simultaneous use of drugs that block tubular secretion, reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (the concentration in the blood increases).

Analogs of the drug Furadonin

The drug Furadonin has no structural analogs for the active substance.

Analogs in terms of the effect ( antibacterial drugs, nitrofuran derivatives):

• Furagin;
• Furazidine;
• Furamag;
• Furasol.

In the absence of analogues of the drug for the active substance, you can follow the links below to the diseases for which the corresponding drug helps, and see the available analogues for the therapeutic effect.

Broad-spectrum antimicrobial agent, nitrofuran derivative. It has a bacteriostatic and bactericidal effect in urinary tract infections. Nitrofurantoin is active against Escherichia coli, Klebsiella spp., Enterobacter spp., Proteus spp.

It is mainly effective for urinary tract infections.

Pharmacokinetics

Well absorbed from the gastrointestinal tract. Bioavailability is 50% (food increases bioavailability). The absorption rate depends on the size of the crystals (the microcrystalline form is characterized by rapid solubility and absorption rate, a short time to reach C max in urine). Plasma protein binding - 60%. Metabolized in the liver and muscle tissue. T 1/2 - 20-25 min. Penetrates the BBB, placental barrier, excreted in breast milk. It is excreted completely by the kidneys (30-50% - unchanged).

Release form

10 pieces. - contour cell packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (4) - cardboard packs.
20 pcs. - contour cell packaging (1) - cardboard packs.
25 pcs. - contour cell packaging (1) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.

Dosage

The dose for adults is 50-100 mg, the frequency of use is 4 times / day. The daily dose for children is 5-7 mg / kg in 4 divided doses. The duration of the course of treatment is 7 days. If necessary, it is possible to continue treatment for another 3 days (only after urine control for sterility). During long-term maintenance treatment, the dose of nitrofurantoin should be reduced.

Interaction

The simultaneous use of nalidixic acid and antacids containing magnesium trisilicate reduces the antibacterial effect of nitrofurantoin.

Nitrofurantoin is incompatible with fluoroquinolones.

With the simultaneous use of drugs that block tubular secretion, reduce the antibacterial effect of nitrofurantoin (by reducing the concentration of nitrofurantoin in the urine) and increase its toxicity (the concentration in the blood increases).

Side effects

From the respiratory system: chest pain, cough, shortness of breath, pulmonary infiltrates, eosinophilia, interstitial pneumonitis or fibrosis, decreased respiratory function, bronchial asthma attack in patients with a history of asthma.

From the side digestive system: feeling of discomfort in the epigastrium, anorexia, nausea, vomiting; rarely - hepatitis, cholestatic jaundice, abdominal pain, diarrhea.

From the side of the central nervous system and peripheral nervous system: peripheral neuropathy, headache, nystagmus, dizziness, drowsiness.

From the hematopoietic system: leukopenia, granulocytopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, megaloblastic anemia (these changes are reversible).

Allergic reactions: urticaria, Quincke's edema, pruritus, rash; very rarely - anaphylactic shock.

Dermatological reactions: exfoliative dermatitis, erythema multiforme.

Others: drug fever, arthralgia, flu-like symptoms are possible, superinfection of the genitourinary tract, often caused by Pseudomonas aeruginosa.

Indications

Infectious and inflammatory diseases of the urinary tract (including pyelonephritis, cystitis) caused by microorganisms sensitive to nitrofurantoin.

Contraindications

Severe disorders of renal excretory function, renal failure, oliguria, insufficiency of glucose-6-phosphate dehydrogenase, pregnancy, early childhood (up to 1 month), hypersensitivity to nitrofurantoin, stage II-III heart failure, liver cirrhosis, chronic hepatitis, acute porphyria, lactation.

Application features

Application during pregnancy and lactation

Nitrofurantoin is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of liver function

Contraindicated in liver cirrhosis, chronic hepatitis.

Application for impaired renal function

Contraindicated in severe disorders of renal excretory function, renal failure, oliguria. The risk of developing peripheral neuropathy increases in patients with severe renal failure.

Application in children

Contraindicated in the early childhood(up to 1 month).

special instructions

The risk of developing peripheral neuropathy increases in patients with anemia, diabetes mellitus, electrolyte imbalance, deficiency of B vitamins, severe renal failure.

Nitrofurantoin should not be used to treat diseases of the renal cortex, with purulent paranephritis and prostatitis. Nitrofurantoin is not prescribed in combination with drugs that cause renal impairment.