Rami Sandoz is a highly effective drug developed by the renowned pharmaceutical company Sandoz GmbH.

It is prescribed both in complex and independent therapy. arterial hypertension and chronic heart failure, as well as in order to prevent myocardial infarction in ischemic disease hearts.

The main active ingredient is ramipril, an active antihypertensive substance from the group of ACE inhibitors.

Presented in the form of tablets, this medication is intended for daily intake throughout the course, determined by the doctor.

More information about Rami Sandoz will be useful to anyone who is going to take this drug.

Composition and form of release

The active ingredient of Rami Sandoz is ramipril. It is a highly effective antihypertensive agent belonging to the category of angiotensin-converting enzyme inhibitors and is widely used in the treatment of diseases of the cardiovascular system.

Also included are auxiliary components:

• microcrystalline cellulose;
• pregelatinized starch;
• precipitated dioxide;
• yellow iron oxide;
• red iron dioxide.

This medication is produced in the form of tablets containing various dosages of the active substance - 0.0025 g, 0.005 g and 0.01 g.

pharmachologic effect

As a result of the use of the drug Rami Sandoz, the distal resistance of the arterial walls is significantly reduced.

In patients with severe symptoms arterial hypertension, there is a decrease in indicators blood pressure... In this case, the heart rate does not increase.

In most cases, patients' blood pressure stabilizes within 60-120 minutes after taking the medication. And after 4-5 hours, the maximum therapeutic effect is achieved, which remains for the next 24 hours.

After 21-30 days, subject to regular use of the drug, the maximum therapeutic effect is achieved.

Indications for use

Rami Sandoz tablets are prescribed for the following diseases and conditions:

• severe initial or glomerular stage of nephropathy, which may or may not be associated with diabetes mellitus;
• heart failure resulting from myocardial infarction;
• diabetes mellitus, accompanied by one or more risks of development cardiovascular disease(smoking, high blood pressure, high general level cholesterol);
• peripheral vascular disease;

This drug is often prescribed for coronary heart disease to effectively prevent heart attacks and strokes.

Mode of application

To achieve optimal therapeutic effect it is necessary to take the drug Rami Sandoz every day, strictly at a certain time.

You can take the medicine both before and after eating, as this does not affect the process of its absorption.

One tablet should be swallowed whole without dissolving or chewing. Only in some cases is it permissible to divide the tablet into two equal parts. Be sure to drink plenty of fluids.

Depending on the patient's age, symptoms of the disease and some other factors, daily dosages may vary.

In the treatment of arterial hypertension, an initial dose of 2.5 mg of the drug per day is prescribed, however, if necessary, it can be doubled after every 2-4 weeks of admission.

In some cases, instead of increasing the dosage, calcium antagonists and diuretics are prescribed simultaneously with Rami Sandoz tablets, which are characterized by a mild hypertensive effect. As a maintenance dosage, usually from 2.5 to 5 mg of the drug per day is prescribed. The maximum allowable dosage for adult patients is 10 milligrams.

Patients suffering from chronic heart failure are prescribed 1.25 mg of the drug once a day. However, if at such a dosage it is not possible to achieve the required therapeutic effect, it can be doubled after 1-2 weeks. When prescribing a dosage of 2.5 mg, it can be divided into two doses.

In case of postinfarction, it is necessary to take the drug at a dosage of 2.5 mg twice a day in the first 48 hours. The duration of the course of treatment is three days. If the indicated dose is difficult to tolerate by the patient, it is reduced to 1.25 mg in the first two days, and then increased every 1-3 days of administration.

In the treatment of diabetic or non-diabetic nephropathy, an initial daily dosage of 1.25 mg of the drug is prescribed. Then, after every two days, it is recommended to double the dosage until the optimal maintenance level is reached - 5 mg.

In order to prevent myocardial infarctions and strokes, as well as to reduce the risk of mortality as a result of the development of diseases of the cardiovascular system, the following dosages are prescribed: for 1-2 weeks, 2.5 mg of the drug once a day, and then every 2-3 weeks it must be increased to a maintenance level of 10 mg per day.

In the treatment of renal failure, the daily dosage of the drug is prescribed to the patient individually, depending on the creatinine clearance.

Interaction with other medicinal products

Before you start taking Rami Sandoz, it is important to take into account the peculiarities of its interaction with other drugs.

The antihypertensive effect of these tablets is enhanced when taken together with other antihypertensive drugs, as well as anesthetics, tricyclics, antipsychotic drugs, as well as drugs containing opium.

The antihypertensive property of Rami Sandoz decreases when taken simultaneously with anti-inflammatory nonsteroidal drugs (aspirin, indomethacin, etc.), sympathomimetics, drugs with estrogen, as well as drugs and food, which contain salt.

As a result of taking the drug together with medicines containing potassium, the concentration of this element in the blood serum increases significantly.

Simultaneous use with drugs belonging to the categories of immunosuppressants, corticosteroids and cytostatics leads to an increased risk of leukopenia.

When Rami Sandoz tablets are combined with drugs intended to treat diabetes mellitus, the hypoglycemic effect may increase.

Side effects

Side effects

Despite such an extensive list side effects, in practice, they happen extremely rarely - as a rule, as a result of non-compliance with the rules for taking the drug.

Overdose

Taking a higher than the permissible dose of the drug is fraught with such consequences as hypotension and arterial collapse, slowing down of heart activity, impaired natural renal function, as well as impaired electrolyte metabolism.

Contraindications

Rami Sandoz tablets are contraindicated in a number of conditions, including:

• individual intolerance to the components or excessive sensitivity to them;
• arterial hypotension;
• a history of angioedema;
• severe renal failure;
• primary hyperaldosteronism;
• hemodynamic instability;
• unilateral or bilateral renal artery stenosis;
• childhood.

During pregnancy

During pregnancy and lactation, the use of Rami Sandoz is contraindicated. If the patient becomes pregnant during the course of treatment, it is necessary to immediately stop further taking these pills.

Alternatively, the doctor should prescribe therapy without the use of ACE inhibitor drugs.

Storage conditions and periods

The medication can be stored for two years. The main thing is that the packaging is original, and the temperature in the room does not exceed 25 degrees.

Price

Rami Sandoz is a prescription drug. Its average cost in Russian pharmacies ranges from 200 to 630 rubles.

Most pharmacies on the territory of Ukraine you can buy Rami Sandoz tablets for about 70-150 hryvnia.

Analogs

The most effective analogues of Rami Sandoz, which have the same active substance, relate:

In addition, there are several analogs characterized by identical action and method of application. Among them:

• Hiten;

Before choosing the most optimal option, it is recommended to consult a doctor.

Prevention and treatment of calcium deficiency; prevention and treatment of osteoporosis (in combination therapy); treatment of rickets and osteomalacia (in combination therapy with vitamin D3).

Pharmacotherapeutic group

Calcium-phosphorus metabolism regulator.

Pharmacological property

Calcium is a vital mineral that is essential for maintaining the balance of electrolytes in the body and for the adequate functioning of numerous regulatory mechanisms. Replenishes the deficiency of Ca2 + in the body, participates in phosphate-calcium metabolism, has a vitamin, anti-rachitic, anti-inflammatory and anti-allergic effect. Calcium Sandoz Forte contains two calcium salts (calcium lactogluconate and calcium carbonate), which in the form of effervescent tablets dissolve quickly in water, turning into an active ionized form of calcium, which is easily absorbed. This dosage form provides an adequate intake of calcium in the body in the form of a tasty drink and is intended for the prevention and treatment of acute and chronic calcium deficiency in the body, as well as for the treatment of various types of metabolic disorders in bone tissue.

Contraindications

Hypersensitivity to the components of the drug, increased concentration of calcium in the blood and urine (hypercalcemia, hypercalciuria), chronic renal failure, nephrourolithiasis, nephrocalcinosis, phenylketonuria and sucrose / isomaltose deficiency, fructose intolerance, glucose-galactose malabsorption. Calcium Sandoz Forte is not recommended for use in children under 3 years of age due to the lack of data on efficacy and safety in this category.

Application

Inside, regardless of food intake. Before taking the tablet, dissolve in a glass of water. Children from 3 to 9 years old: 500 mg per day. Adults and children from 10 years old: 1000 mg per day. In severe cases or with increased calcium requirements (for example, in the treatment of bisphosphonates), the dose may be increased to 2000 mg per day. Duration of therapy : when used for the prevention and treatment of calcium deficiency, the average duration of the course of treatment is at least 4 - 6 weeks; when used for the prevention and treatment of osteoporosis, treatment of rickets and osteomalacia, the duration of treatment is determined individually.

Side effects

Immune system disorders: rarely: hypersensitivity reactions, incl. rash, itching, hives; very rare: in isolated cases, systemic allergic reactions (such as anaphylactic reactions, facial edema, angioedema) have been reported. Metabolic and nutritional disorders: infrequently: hypercalcemia, hypercalciuria. Violations from the outside gastrointestinal tract: rare: flatulence, constipation, diarrhea, nausea, vomiting, abdominal pain. When taken in high doses (2000 mg / day with daily intake for several months), headache, increased fatigue, thirst, and polyuria may occur.

Overdose

Overdose leads to the development of hypercalciuria and hypercalcemia. Symptoms of hypercalcemia include nausea, vomiting, thirst, polydipsia, polyuria, dehydration, and constipation. Chronic overdose with the development of hypercalcemia can lead to liming of blood vessels and organs. The threshold of calcium intoxication - when taking calcium supplements for several months at a dose exceeding 2000 mg / day. Therapy in case of overdose In case of intoxication, the therapy should be stopped immediately and the water-electrolyte balance should be restored. In case of chronic overdose, if signs of hypercalcemia are detected, hydration is performed at the initial stage with 0.9% sodium chloride solution. Loop diuretics such as furosemide can be used to enhance calcium excretion and to avoid tissue edema (eg, in congestive heart failure). In this case, you should refrain from using thiazide diuretics. In patients with renal failure hydration is ineffective, dialysis is indicated for such patients. In the case of persistent hypercalcemia, other factors contributing to its development should be excluded, including vitamin A or D hypervitaminosis, primary hyperparathyroidism, malignant tumors, renal failure, and stiffness of movement.

Interaction with other medicinal products

The combination of calcium carbonate + calcium lactogluconate & may reduce the absorption of estramustine, etidronate and possibly other bisphosphonates, phenytoin, quinolones, oral tetracycline antibiotics, and fluoride preparations. The interval between taking tablets of effervescent calcium carbonate + calcium lactogluconate & and the above preparations should be at least 3 hours. The simultaneous administration of vitamin D and its derivatives increases the absorption of calcium. When given in high doses along with vitamin D and its derivatives, calcium can reduce the effects of verapamil and possibly other calcium channel blockers. With the simultaneous use of effervescent tablets of calcium carbonate + calcium lactogluconate & and tetracycline preparations, the absorption of the latter may be impaired. For this reason, tetracycline preparations should be taken at least 2 hours before or 4-6 hours after oral administration of calcium preparations. Thiazide diuretics reduce urinary calcium excretion, therefore, when used simultaneously with calcium carbonate + calcium lactogluconate effervescent tablets, serum calcium concentration should be monitored regularly, as there is a risk of hypercalcemia. Systemic corticosteroids decrease calcium absorption. With their simultaneous use, it may be necessary to increase the dose of effervescent calcium carbonate + calcium lactogluconate & tablets. When ingesting tablets of effervescent calcium carbonate + calcium lactogluconate & in patients receiving cardiac glycosides, an increase in the toxicity of cardiac glycosides is possible due to the development of hypercalcemia. Such patients should regularly take an ECG and monitor the level of calcium in the blood serum. With the simultaneous administration of sodium bisphosphonate or sodium fluoride, these drugs should be taken at least 3 hours before taking effervescent calcium carbonate + calcium lactogluconate tablets &, since absorption from the gastrointestinal tract (GIT) of bisphosphonate or sodium fluoride may decrease. The absorption of calcium from the gastrointestinal tract can be reduced with the simultaneous intake of certain types of food containing oxalic acid (for example, spinach, rhubarb) or phytic acid (in all grains) due to the formation of insoluble complexes with calcium ions. Patients should not take an effervescent tablet of calcium carbonate + calcium lactogluconate & 2 hours before or after a meal rich in oxalic or phytic acid.

Sandoz is a world leader in generics and biosimilars, a division of the Novartis Group. Our mission is to find new ways to improve the quality and life expectancy of people. Sandoz's goal is to open up new opportunities for people around the world to access high-quality medicine by helping communities meet the growing health needs.

The company's product portfolio consists of more than 1,000 molecules covering all major therapeutic areas of medicine. The company's wide product line allows patients and healthcare organizations to significantly reduce costs in the long term. This contributes to the sustainability of health systems by reducing the financial burden and freeing up funds for the development of innovative drugs.

Our products are represented in the markets of more than 160 countries around the world. More than 500 million patients are already using them, and we are aiming to increase the number of patients to one billion. A special place in our diversified portfolio of about 1,000 molecules is occupied by biosimilars - advanced non-proprietary biological products, as well as antibiotics, drugs without which it is impossible to imagine the functioning of the global health system.

We are implementing a number of targeted corporate social responsibility programs aimed at the most needy groups of the population. These initiatives are aimed at meeting the needs of socially vulnerable groups of the population in medical care, expanding access to medical information and creating conditions for the development of medicine.

Sandoz's sales in 2016 were $ 10.1 billion. The headquarters is located in Holzkirchen (Germany).

A Council of Experts on Nephrology was held in St. Petersburg with the support of Sandoz

The topic of the Council is “Scientific and practical approaches to overcoming resistance to erythropoiesis-stimulating therapy in patients with anemia in chronic kidney disease”.
Leading specialists in the field of nephrology of Russia and foreign experts took part in the meeting of the Council of Experts.

One of the important factors in the pathogenesis of renal anemia is a decrease in the production of endogenous erythropoietin, a hormone that stimulates the erythrocyte link of hematopoiesis. Implementation in clinical practice In 1987, the use of recombinant erythropoietin (EPO) preparations revolutionized the treatment strategy and outcomes of anemia in patients with CKD.

However, despite the use of high-tech treatment methods - erythropoiesis-stimulating drugs (ESP), the achievement of target hemoglobin values ​​is not always possible. Approximately 10–20% of patients with renal anemia have decreased sensitivity or resistance to ESP treatment. Such resistance is a predictor of poor prognosis and increased mortality of any etiology, regardless of other risk factors. The problem of reduced response to ESF therapy in current clinical guidelines not paid enough attention and needs improvement.

> Sandoz / Sandoz, ZAO (Moscow)

This information cannot be used for self-medication!
Consultation with a specialist is imperative!

The international pharmaceutical company Sandoz / Sandoz, which has been supplying its products to the market for more than a century, is today one of the world leaders in the production of quality generics. The range of the company's products is represented by solid, liquid and soft dosage forms and covers almost all pharmacotherapeutic groups.

Sandoz is headquartered in the German city of Holzkirchen in Bavaria. The production units of the company are located on the European continent, as well as in the USA, Canada, Argentina, and India. Over the past decade, Sandoz's manufacturing base has expanded through acquisitions of companies such as Lek (Slovenia), Sabex (Canada), Hexal (Germany), Eon Labs and Oriel Therapeutics (USA), EBEWE Pharma (Austria).

The Russian division is represented by CJSC Sandoz, which promotes the company's products on the Russian market. About 60 types of drugs are sold in Russia, and in 2017, with the launch of a new modern plant near St. Petersburg, their list will significantly expand.

Sandoz produces:

• tableted antibiotics of various groups Abaktal, Amoxiclav, Amoxicillin Sandoz, including dispersible tablets Amoxiclav Kviktab;


• parenteral antibiotics Abaktal, Amoxiclav, Cefazolin Sandoz, Lendacin;


• antihypertensive tablet monopreparations Amlodipine Sandoz, Biol, Carvedilol Sandoz, Doxazosin Sandoz, Lozarel, Moxonitex, Nifecard and combined remedy Atenolol compositum Sandoz;


• antiviral agent Acyclovir Sandoz in the form of a cream for the treatment of skin manifestations of herpes infection;


• mucolytic agents for adults and children ACC, ACC 100, ACC 200, ACC 400, ACC long in granules and effervescent tablets, as well as ACC inject in ampoules, facilitating coughing up in violation of the discharge of bronchial secretions;


• antibacterial external agent containing two antibiotics, Baneocin in powder and in the form of an ointment for the treatment of bacterial skin lesions, sensitive to the drug;


• anti-anemic drug in injection solution Binocrit- stimulator of the formation and accelerated maturation of erythrocytes in the bone marrow;


• immunostimulants Broncho-munal, Broncho-munal P in capsules that activate the immune defense when it decreases as a result of infectious lesions of the respiratory tract;


• external venotonic gel Venitan, cream Venitan N with horse chestnut extract and combination drug Venitan forte in the form of a gel for the treatment of saphenous veins pathology;


• enzyme preparation Gastenorm forte containing essential digestive enzymes to facilitate the work of the pancreas;


• antiparkinsonian drug On whom providing a subsidence of severity clinical symptoms illness;


• intestinal biocenosis regulator Linex in capsules with high probiotic activity;


• herbal antidepressants Deprim in pill form and Deprim forte in capsules with a mild sedative effect;


• antibacterial dermatological cream Dermazin with active silver for wound healing;


• external analgesic Diklak in the form of a gel, effective for radiculitis, myositis, superficial injuries;


• tableted non-steroidal drug Diclofenac Sandoz for the treatment of pain and swelling of an inflammatory nature;


• anti-inflammatory non-steroidal drugs in tablets Ketonal, Ketonal uno, Ketonal duo, as well as Ketonal thermo in the form of a patch with a pronounced analgesic effect;


• hemostatic agent Dicinon in tablets and ampoules for the treatment of all types of bleeding;


• antifungal drug for the systemic therapy of candidiasis Fluconazole Sandoz in capsules;


• herbal remedy Immunal in tablets and oral solution to stimulate the immune defense;


• antiallergic agent Lomilan in tablets and in the form of an oral suspension;


• antidiarrheal symptomatic remedy Lopedium in capsules and tablets;


• antiulcer capsule Omeprazole Sandoz, which reduces the acidity of the stomach;


• antifungal cream and external solution Exoderil for the treatment of fungal skin lesions.

Russia is one of the most important markets for Sandoz. The strong position of our products, based on their high quality and reputation, optimal price and wide range the use of generics allows the company to occupy a strong position among the leaders of the Russian pharmaceutical industry.

We are proud of the consistently high quality of Sandoz medicines, which are produced for Russia at the largest pharmaceutical factories in Europe. The optimal price and availability of drugs is due to the fact that innovative solutions and innovative technologies are used for their production.

The range of Sandoz products in Russia includes all major therapeutic groups. Among the most important are antibiotics (anti-infectious drugs), drugs used for disorders of the central nervous system, drugs for the treatment of diseases of the gastrointestinal tract, drugs for the treatment of cardiovascular diseases, drugs for the treatment of diseases musculoskeletal system, iron preparations for the treatment of anemia, immunomodulators, basic chemotherapy drugs. An important place in the portfolio is occupied by OTC drugs (over-the-counter): Linex®, ACC®, Exoderil®, Baneocin®, Immunal®, etc.

We work closely with pharmacies, health care institutions and doctors, sharing our experience in the fight against various diseases and provide doctors with the latest information they need when working with patients. We not only manufacture and sell medicines, but also actively participate in the scientific and practical life of Russian healthcare.

Memorandum of Intent signed by Novartis with the city of St. Petersburg on the construction of a full-scale manufacturing enterprise full cycle, represents an important step forward in the company's activities in Russia. With a capacity of approximately 1.5 billion units per year, the plant is expected to produce both original innovative drugs and high-quality generics. Most of the expected production volume will come from generics, and thus the facility will significantly increase Sandoz's ability to distribute our medicines to Russian patients, helping to strengthen the local healthcare system and improve treatment outcomes in Russia.

As an international company, Sandoz is committed to helping the community wherever it operates.

Every year, as part of the Social Partnership Day, a charity event in which Novartis companies all over the world take part, our employees support those who need it most. In Russia, Sandoz has been helping orphanages and orphanages in Moscow and the Moscow Region for several years. We plan to expand the geography of the company's charitable assistance in the regions of Russia.