The use of potato starch, polyvinyl acetate, magnesium stearate, carbomer 934p, carboxymethyl starch of sodium type A, colloidal diesel engine and talc is necessary in the form of auxiliary means.

Tablets have a white color or grayish tint. The shape is round, flat with chamfer and engraving "Halidor" on one of the sides. Possess a weak characteristic odor. Packed in a jar of dark glass for 50 pieces. Instructions included.

The solution is sold in ampoules and is intended for intramuscular or intravenous administration. In each ampoule, 50 mg per 1 ml of the active actant.

Sodium chloride and up to 2 ml of purified water are also used. Fasted in boxes of 10 ampoules. Instructions included.

How does Galidor act?

Active substances, falling into the body, has a vasodilatory action. This feature exists due to the ability of beziclan to block calcium channels and due to antiserotonin action.

The best effect is noticeable in the peripheral areas in the brain area. Perfectly removes the spasms of the respiratory organs, the urogenital system and gastrointestinal tract.

It is quite well absorbed and absorbed by the gastrointestinal tract, if taken in the form of tablets. The maximum concentration in the blood plasma is achieved after 3 hours, but in some cases the maximum effect occurs after 5-8 hours. Most of the active substance disintegrates in the liver, approximately 70-75%.

The half-life of the substance occurs within 10 hours. It is usually excreted in the form of inactive metabolites, but approximately 3% of the drug leaves the body unchanged.

The time required for the withdrawal of medicine from the body does not even increase in older people and patients suffering from kidney and liver problems.

Galidor is almost a versatile agent. It is prescribed in many cases. The main ones are:

Method of application and dose

When diagnosing vascular diseases, the Galidor needs to be used inward in the form of 100 mg tablets 3 times a day. The course of treatment is 2-3 months. The limit daily rate should not exceed 400 mg.

If applications in the form of infusion, then daily dose It is 200 mg that must be divided into two receptions. Before use, 100 mg of the preparation is required in 100-200 ml of isotonic sodium chloride solution. Introduction occurs drip by 1 hour 2 times a day.

When combating spasms, Galidor is used in the tablets in the dosage of 100-200 mg at a time. The duration of the course of treatment is determined by the doctor.

Supporting therapy involves using 1 tablet 3 times a day for a month. The dose is then reduced to 1 tablet 2 times a day. A complete course of maintenance therapy is strictly individual and continues until the very disappearance of the symptoms of the disease. As a rule, treatment lasts 1-2 months.

Acute forms of spasms forced doctors to prescribe an intravenous drug at 100-200 mg (4-8 ml). With intramuscular administration, 10-20 ml of solution is necessary. Treatment lasts within 2-3 weeks.

Combine Galidor needs carefully, since in some cases they can develop side effects . So, it is worth taking with special care sedatives and means used in anesthesia. This may lead to an increase in the effect of the active substance on the central nervous system.

Tachycardia can develop with simultaneous preparation with sympathomimetics. It is not recommended to take with diuretics and cardiac glycosides, as well as with calcium channel blockers and beta-adrenobloclars.

Thinking drugs can also cause a number of side effects, and aspirin enhances the braking process of blood platelet aggregation.

Side effects

It is possible a disorder of the gastrointestinal tract. In this case, nausea appears, vomiting, diarrhea, abdominal pain and dry mouth. The absence of appetite and activation of hepatic traxaminases are not excluded.

The impact on the central nervous system is caused by dizziness and headaches. But sometimes there is also insomnia, unfortunate concern, tremors, problems with memory, confusion, the manifestation of epilepsy, hallucinations. There were isolated cases of focal lesions of the central nervous system.

The impact on the cardiovascular system can provoke tachyritium.

Also, the patient can feel general malaise and weakness, it may appear allergic reactionsSometimes a quick and unweddable set of body weight is diagnosed. With internal administration, thrombophlebitis is possible.

Contraindications

This drug cannot be taken in the presence of individual hypersensitivity to substances that are in the composition of the drug. He is also contraindicated to persons under the age of 18.

It is not recommended to assign in difficult problems with the respiratory system and when problems with liver and kidneys. Myocardial infarction, the use of AV blockade, epilepsy and acute form of tachycardia are also considered to be contraindicated.

It is forbidden to assign a Halian if the patient recently suffered a hemorrhagic stroke or a cranopy brain injury. Negative effect on the fruit can be rendered during pregnancy. The drug falls in breast milkTherefore, during the lactation period, it is required to refuse.

special instructions

There is an impact on the ability to control the vehicle and other mechanisms, so at the time of therapy it is better to abandon travel by car driving and from work requiring immediate reaction.

Terms and Storage Terms

The drug must be stored in ampoules no more than 3 years, and in tablets no more than 5 years. It is strictly prohibited to use its use after the expiration date.

It is stored as room temperature In an inaccessible place for children.

Price

The price is highly dependent on the pharmacy kiosk and the region. In Russia, tablets are sold on average for 500 rubles, and in Ukraine for 200 hryvnia.

The substance in ampoules can be bought in the Russian Federation for 500-600 rubles, while in Ukraine the value of the ampoules does not differ from the price of the drug in the tablets. Recommended by a doctor's prescription.

Analogs

Bencyclan, Bencyclan Fumarate, Vinoxin MV, Dibazol, Dibazol Darnitsa, Duzofarm and Elelbin 100 retard can be used as analogs.

Medical Instructions

drug

GalidorÒ

Tradename

Galidor Ò.

International non-proprietary title

Bencyclan.

Dosage form

Injection Solution, 25mg / ml

1 ml of solution contains

active substance- Bencyclan Fumarate 25 mg,

excipients: sodium chloride, water for injection.

Description

Transparent aqueous solution without smell.

Pharmacotherapeutic group

Other peripheral vasodilators. Bencyclan.

Code ATH C04A x11

Pharmacological properties

Pharmacokinetics

The maximum concentration in the blood plasma is reached after 2-8 hours (usually after 3 hours) after intake. Due to the metabolism of the first passage through the liver, the bioavailability of the drug after intake is 25-35%. Approximately 30-40% of the amount of bentheclane in circulating blood is associated with plasma proteins, 30% with red blood cells, 10% with platelets; The free fraction is 20%. Metabolism is carried out in the liver, mainly in two ways: dealekilization gives a demethylated derivative, the rupture of the ether communication gives benzoic acid, which in the future turns into hypproves. The main part of the administered dose is excreted by the kidneys, mainly in the form of metabolites, but also unchanged (2-3%). The overwhelming majority of metabolites (90%) are excreted in unconjugated form, and a small part is excreted in conjugated form (approximately 50% in the form of a conjugate with glucuronic acid). Half-life of 6-10 hours; This parameter does not change in elderly patients, as well as in violation of the kidney and liver functions. The total clearance is 40 l / h, the kidney clearance is less than 1 l / h.

Pharmacodynamics

Galidor has a vasodilatory action, which is mainly due to its ability to block calcium channels and to a lesser extent with a blockade of sympathetic ganglia. There are data indicating the ability of beziclan to cause a dose-dependent suppression of Na / k - ATPase and platelet aggregation, as well as an increase in the ability of erythrocytes to deformation. These effects are observed mainly in the peripheral vessels, coronary arteries and brain vessels. In addition, Galidor has antispasmodic effect on the smooth muscles of the gastrointestinal tract, urinary organs, respiratory tract. The drug causes some increase in cardiac frequency. It also knows its weak tranquilizing effect.

Indications for use

Vascular diseases:

Diseases of peripheral vessels: Reino disease, other diseases, accompanied by acrolation and vessel spasms, as well as conditions caused by occlusion arteries

As part complex therapy Brain circulation disorders

Elimination of spasm internal organs:

Gastrointestinal diseases: Gastroenteritis various etiology (especially infectious), infectious and inflammatory colitis, functional diseases of the large intestine, tenesms, postoperative meteorism, cholecystitis, bile disease, condition after cholecystectomy, motility disorders when the sphincter is died, ulcerative disease Stomach I. duodenal gut in combination with other drugs

Urological syndromes: Tenses bladderAdditional therapy urolithiasis (in combination with analgesics when renal colic) preparation for tool methods Research

Method of application and dose

A solution for intramuscular or intravenous (after dilution) of administration, as well as for infusion. For intravenous administration, the contents of the ampoule should dilute with a 0.9% sodium chloride solution.

Vascular diseases: Introduction by infusion in a daily dose of 200-300 mg, divided by 2-3 infusions; Infusion should be slowly approximately for 1 hour.

Elimination of the spasm of internal organs: for acute forms Diseases are injected intravenously slow 2-4 ampoules of the drug, diluted with saline to 10-20 ml or 50 mg intramuscularly.

The duration of treatment is determined by the doctor individually depending on the clinical state of the patient.

Opening ampoules (for right-handers):

Take the ampoule housing to the left hand, between large and bent index fingers. The breakpoint should be at the top (Fig. 1). Hold the ampoule head between a large and bent index finger right hand In the way that thumb It was at a break point, covering it (Fig. 2). Relying on the index finger of the left hand, press on the ampoule big finger The right hand, thus, in this way, the constant pressure of the middle force. Do not bring the right and left hands from each other (Fig.3). The cervix can crack at any time after pressing that you may not feel

Side effects

- Dry mouth, pain in the stomach, feeling of satiety, nausea, vomiting

- Sporadic anxiety headache, dizziness, violation of gait, tremor, drowsiness, sleep disorder, memory violation

Tonic and clonic convulsions with significant overdose

- Transient increase in the activity of hepatic enzymes, leukopenia

- general malaise, body weight increase

- thrombophlebitis (for intravenous administration)

maybe

- atrial or ventricular tachyarithmia (especially with joint introduction with other pro-aminogenic drugs)

- Allergic reactions

ABOUTchen rareabout

Symptoms of focal damage to the central nervous system

Contraindications

Increased sensitivity to active or other component of the drug

Heavy breathing, renal or liver failure

Decompensated heart failure, acute myocardial infarction, atrial stomach blockade

Epilepsy, various forms Spasofilius

Recently suffered stroke

Card and brain injury for the last 12 months

Pregnancy and lactation (relative contraindication)

Children's age up to 18 years

Medicinal interactions

Care should be taken when combinations with the following means:

Anesthetics and sedatives (their effects can enhance)

Sympathomimetics (due to the risk of atrial and ventricular tahiaritimi)

Means that reduce potassium content in blood, quinidine (due to the possible sum of the pro-athmogenic effects)

Drugs against the drugs (risk of arrhythmias in overdose of ingredients)

- β-adrenobloclars (due to the opposite of chronotropic effects - (negative in β-blocks and positive at bentheclane) may need to select the dosage of β-blocker)

Calcium channel blockers and other antihypertensive preparations (due to the possibility of the summation of these effects)

With preparations S. by the side reactionreinforcing spasmophilia (due to the possibility of the sum of these effects)

Aspirin (due to increased braking of platelet aggregation)

special instructions

The injection places should be periodically changed, as the drug can cause damage to the endothelium of vessels and thrombophlebitis.

It should be refracted from the parenteral administration of the drug with patients with cardiovascular and respiratory failure, predisposed to the collapse, as well as with hypertrophy prostatic gland and urine delay (the delay of the delay increases with the relaxation of the muscles of the bladder).

Pregnancy and lactation period

Despite the absence of embryotoxic effects with a wide use of the drug, the use of the drug in the I trimester of pregnancy is not recommended. Due to the lack of reliable data, the use of the drug during the period breastfeeding Requires special caution.

Features of the influence of the drug on the ability to control the vehicle or potentially hazardous mechanisms.At the beginning of the course of treatment, management vehicles and potentially hazardous activities requiring increased concentration and speed of psychomotor reactions require special caution.

Overdose

Symptoms: Beating heartfills, decline arterial pressure, predisposition to collapse, urine incontinence, drowsiness, anxiety, psychomotor excitement, and in severe cases - epileptiform convulsive seizures.

Treatment: Specific antidote is unknown. Symptomatic therapy, stomach wash. When developing convulsive seizures, benzodiazepines are recommended. There are no data on the possible removal of beziclan by means of dialysis.

Release form and packaging

2 ml in ampoules made of colorless neutral glass with a break point. On the whine of the ampoules are applied in the influsable paint code ring of blue (bottom ring) and light yellow (top ring).

Galidor is in its own pharmacological group antispasmodic drug. Active substance Performs benticlan. The drug form of the drug is a colorless transparent solution without smell, intended for parenteral administration (both intravenously and intramuscularly).

Each ampoule contains 50 mg of the active substance of the fumaranta benthal (concentration of 25 mg / ml), the auxiliaries are represented by a physiological solution for parenteral dosage forms 8 ml volume, water for injection 2 ml.

The release form of 2 ml ampoules, has a break point and two rings (blue and yellow - upper).
Pharmacodynamically Galidor is antispasmodiccombining along with myotropic and vasodilative effect.

Bencyclan acts spasmolitically on the visceral muscles of internal organs - the gastrointestinal tract, urinary, also respiratory organs. The vasodulating effect of beziclan is based on blocking ion channels for calcium, as well as antiserotonin action and (to a lesser extent) with the possibility of blockade of sympathetic ganglia. Also, the Galidor can increase the heart rate, as well as cause a small tranquilizing effect.

The drug has a dose-dependent suppression of sodium-wide-dependent ATP-AZA, reduces the level of aggregation of platelets and erythrocytes, increases elasticity of erythrocytes. This is observed mainly in the microcirculatory line of peripheral blood circulation, coronary arteries and brain vessels.

Pharmacokinetically, the maximum concentrations of the Galidore in the blood plasma is reached after 2-7 hours (as a rule, after 3 hours) after use. Approximately 30% of the amount of Galideor binds to plasma proteins, 30% is associated with erythrocytes, and 10% with platelets, the amount of free circulating fraction is 20% of the total number.

The metabolism is hepatic, mainly in two ways: dealekillation (with the formation of a demethylated derivative), as well as a rupture of ether communication (the formation of benzoic acid, followed by its transformation into hypprove acid). The main part of the administered dose of Galidor is excreted by the kidneys, mainly in the form of its metabolites, in an unchanged form of about 2-3%. A greater amount of metabolites (over 80%) is removed in the free state, and a small part in conjugated with glukeeran acid.

The half-life is 6-10 hours and does not depend on the age of the patient, and also does not decrease in the suffering of kidney and liver functions. The total clearance is 40 l / h, the kidney clearance is less than 1 l / h.

Indications

Galidor is shown to use with various neurological and vascular diseases.

• In cases of diseases of the vessels of the brain, Galidor is used as an integral part comprehensive treatment.
• Cases of peripheral vessels, such as, as well as chronic binding diseases of arterial vessels.
• The drug is appointed in cases where it becomes necessary to remove the spasm of the internal organs. This is relevant with such diseases of the gastrointestinal tract as gastroenteritis of various genes (for example, infectious), infectious or inflammatory colitis, as well as functional diseases of the colors, tenesms, meteorism after surgery. Hydior as an antispasmodic can be used at cholecystitis, gallstone disease, after cholecystectomy, in cases of motility disorders when the sphincter is died.
• Galidor is shown in spasms and teensums of the bladder as a concomitant means in the treatment of urolithiasis (should be combined with analgesics with renal colic).
• Used as a means to prepare for diagnostic instrumental research.

Contraindications

The drug has a number of contraindications. These include increased sensitivity to beziclan, cases of severe respiratory, renal, cardiac and liver failure, an atrioventricular blockade or acute myocardial infarction.

Galidor does not apply in the event of epilepsy, other forms of spasmophilia, as well as with a hemorrhagic stroke or severe brain injury transferred over the past year.

Due to the insufficient of reliable research on the use of Galidore in pregnant and nursing women, the appointment of Galidor is not recommended in the first trimester of pregnancy. At the time of breastfeeding, it is also desirable to refuse to use, or for the entire treatment time to stop breast feeding.

Mode of application

The Galidera solution is designed for in / in infusion (after dilution), and can also be used intramuscularly. With vascular diseases, the Galidera solution is prescribed in a daily dose of 200 mg, usually dose is divided into 2 infusions. 100 mg of Galidera is bred in 200 ml of saline.

To eliminate the spasm of internal organs, in acute cases The drug is introduced into Vienna slowly in the amount of 2-4 ampoules (4-8 ml) of the preparation, diluted with saline to 10 ml, or deep intramuscularly 2 ml.

The course of treatment lasts 2-3 weeks, then, if necessary, it is recommended to translate the patient to receive a Halian in a tablet form.

Side effects

Side phenomena from the head of the gastrointestinal tract can occur pain in the stomach, a feeling of fullness, nausea, vomiting. From the side of the century: anxiety, dizziness, breach of gait, tremor, headache, insomnia, hallucinations can develop very rarely.

There are cases of tachyarhythmia (ventricular or atrial, development is significantly more common when combined with other prohitmogenic drugs).

Others sideflines It can be expressed in a state of general indisposition, increasing body weight, in allergic reactions that transient increasing activity of ASAT, Alat, as well as a decrease in the number of leukocytes, rarely have a probability of thrombophlebitis during intravenous administration.

Overdose

The overdose of Galidor is rare. Symptoms in case of overdose: tachycardia, drop blood pressure, drowsiness, urinary incontinence, with expressed overdose, epileptiform convulsive seizures are possible.

Due to the absence of a specific antidote, symptomatic therapy is used in cases of overdose. Benzodiazepines are shown to remove convulsive seizures. The effectiveness of dialysis in the overdose of benthesiclane is doubtful, but there is no reliable data.

special instructions

In cases shared applicationIt is required to be careful when combining with a number of medicines. When using Galidera with anesthetics and sedatives, their effects can sharply increase.

Joint reception with sympathomimetics increases the risk of tachyarhyrahythmias. Dorganic drugs and other drugs that reduce the level of potassium in the blood can lead to the sum of the pro-athmogenic effects. Funds in the admission to be in conjunction with the bencyclane also enhance the risk of arrhythmias, but only in the case of overdose of the latter.

Beta-blockers have the opposite chronotropic effect (positive Galidera and negative from a group of beta blockers), due to the need to select the dosage of beta-blocker. Calcium channel blockers and other antihypertensive preparations when used with a halidor enhance the risk of hypotensive reactions. When using aspirin preparations, platelet aggregation degree increases.

The injection places must be periodically changed, since the Galidor can cause endothelial dysfunction of vessels at the injection site and thrombophlebitis.

It is necessary to refrain from the injection of the drug patients with severe cardiovascular and respiratory failure, predisposed to the collapse. In the hypertrophy of the prostate gland and cases of urine delay increases the risk of urine delay (since the delay is increasing with the relaxation of the smooth muscles of the bladder).

With long-term use of Galideor, it is required to regularly monitor laboratory indicators (at least once every 2 months). Due to the risk of side effects, when taking Galideor, transportation of vehicles and the performance of potentially dangerous work is shown.

Storage conditions

Galidor is stored at room temperature, in an inaccessible place for children. Shelf life for three years.

Analogs

There are no complete analogues of Galideor. Relative analogues may be other with mioral effects.

Price

Galidor is a prescription. Average prices for the drug make up:

• Packaging 10 ampoules 2 ml of 510-615 rubles.

It is impossible to engage in self-appreciation and uncontrolled drug intake. Before using Galide, consult a doctor!

Instructions for use:

Galidor - Miotropic antispasmodic drug pronounced vasodilating action.

Release form and composition

Galidera dosage forms:

• Tablets: round, white or grayish-white, with a slight characteristic odor, chamfer and engraving Halidor on one of the flat sides (50 pcs. In dark glass bottles, in a cardboard pack 1 bottle);
• Solution for intramuscular (in / m) and intravenous (in / c) administration: transparent colorless liquid odorless (in 2 ml ampoules, in the contour cellular pack of 5 ampoules; in a cardboard pack for 2 packs or in a carton 10 packs ).

Active substance - Bencyclan Fumarat:

• 1 tablet - 100 mg;
• 1 ampoule - 50 mg.

Excipients:

• Tablets: Polyvinyl acetate, Potato Starch, Magnesium Stearate, Silicon Dioxide Colloid Anhydrous, Carbomer 934 P, Talc, Sodium Carboxymethyl starch (type A);
• Solution: sodium chloride for parenteral dosage forms, water for injection.

Indications for use

The use of Galidore is shown to treat vascular diseases:

• Peripheral vessels: pathologies with acricyanosis and vessel spasms, Reino disease and chronic binding arterial diseases;
• Brain vessels: chronic and acute cerebral ischemia (as part of comprehensive treatment).

The drug is prescribed to eliminate the spasm of internal organs:

• Gastrointestinal pathologies: as part of the combined therapy of ulcerative disease of the stomach and duodenum, colitis - infectious and inflammatory, gastroenteritis of various etiologies, especially infectious. Cholecystitis, condition after cholecystectomy, gallstone disease, motility disorders when the sphincter dyskinesia is apparently. Functional pathologies of the large intestine, postoperative meteorism, tenesms;
• Urological syndromes: concomitant therapy of urolithiasis (with renal colic - in combination with analgesics), tenesms and spasms of the bladder.

In urology, Galidor is also used to prepare for instrumental research methods.

Contraindications

Contraindications to the use of Galidore are:

• Heavy liver I. renal failure;
• Severe respiratory failure;
• Epilepsy and other forms of spasmodilia;
• Hemorrhagic stroke transferred recently;
• Card-brain injury (over the past year);
• Decompensated heart failure;
• Atrioventricular blockade;
• Acute myocardial infarction;
• Age up to 18 years;
• Pregnancy and breastfeeding period;
• Increased sensitivity to the components of the drug.

Method of application and dosage

Galidor in the form of tablets should be taken inside. In the form of a solution - in the form of in / in injections or infusion and deep in / m injections.

The course of treatment and the drug form of the drug is appointed individually, given clinical Indications and the patient's condition.

• Tablets - 100 mg 3 times a day for 2-3 months. The daily dose should not exceed 400 mg. Break between courses - 2-3 months;
• The solution is 100 mg 2 times a day. 100 mg (4 ml) of the drug must be divorced at 100-200 ml 0.9% aquatic solution Sodium chloride and in / in drip to enter for 1 hour.

Dosing to remove the spasm of internal organs:

• Tablets - 100-200 mg once, the maximum daily dose is 400 mg. Supporting therapy is 100 mg 3 times a day for 3-4 weeks, then 2 times a day. The drug is taken before the disappearance of the symptoms of the disease, usually 1-2 months;
• Solution - in acute cases: 100-200 mg (4-8 ml) by in / in slow injection or 50 mg (2 ml) - deep in / m. For in / in administration, the drug is diluted in 10-20 ml of 0.9% aqueous solution of sodium chloride. The course of treatment for 2-3 weeks, then, if necessary, the patient is transferred to the reception of the tablets.

Side effects

The use of Galidore can cause the following side effects:

• On the part of the central nervous system (CNS): dizziness, headache, anxiety, breach of gait and / or sleep, tremor, memory disorders, insomnia. Rarely - transient matted state of consciousness, hallucinations, epileptiform seizures. Very rarely - symptoms of focal damage to the central nervous system;
• From side digestive system: feeling of satiety, dry mouth, nausea, abdominal pain, vomiting, increase the activity of hepatic transaminases in serum;
• From the side of the cardiovascular system: sometimes - atrial and ventricular tachyrhythmia (especially with the simultaneous introduction of other prohitromogenic drugs);
• Others: an increase in body weight, general malaise, leukopenia, allergic reactions. Rarely - with per / in the introduction, thrombophlebitis may occur.

special instructions

The daily dose of Galideor should not exceed 150-200 mg in combination with heart glycosides, as well as with means that oppress the functions of myocardium or hypocalemia.

Parenteral administration of the drug is contraindicated patient with a severe form of cardiovascular or respiratory failure, which has a predisposition to a collapse; prostate hypertrophy; Delay urine.

In the case of long-term use of the drug, it is recommended at least 1 time in 2 months to carry out laboratory studies of the rheological properties of blood.

When parenteral use periodically, the injections should be changed, because The drug may cause damage to the endothelium of vessels and thrombophlebitis.

At the beginning of the use of Galidore, it is necessary to observe special care when managing vehicles and performing potentially dangerous species Activities.

Medicinal interaction

When combined with sympathomimetics, the likelihood of the development of atrial and ventricular tachyarhythmias, tachycardia increases.

With simultaneous use with anesthetics and sedative preparations, Halidore enhances their depressing effect on the CNS.

With simultaneous reception with drugs, the risk of arrhythmia from possible overdose Cardiac glycosides.

Care should be taken when combination with quinidine and drugs, reduced blood potassium levels (including cardiac glycosides and diuretics), since the sum of the pro-athmogenic effects is possible.

In the case of simultaneous purposes with a halidor of beta-adrenobloclars, it is necessary to consider the opposite of chronotropic effects - positive at bentheclan and negative from beta-adrenobloclars.

The drug can enhance the effect of calcium channels and other antihypertensive drugs.

Simultaneous use with means causing side effects In the form of spasofilius, it can contribute to an increase in these effects twice.

It is necessary to take into account the possibility of enhancing the inhibition of platelet aggregation when combined with acetylsalicylic acid.

Analogs

Galide's analogues are: beziclan, bentheclan fumarate, dibazole, Dibazol Darnitsa, Duzofarm, Vinoksin MV, Papazol, Elelbin 100 retard.

Terms and conditions of storage

The drug should be stored in an inaccessible place at a temperature of 15-25 ° C.

Shelf life:

• Tablets - 5 years;
• The solution is 3 years.

Galidor- Miotropic spasmolitic with a pronounced vazodilative action. Vasodinating action Bencyclane is mainly due to its ability to block calcium channels, antiserotonin action, and to a lesser extent - with blockade of sympathetic ganglia. Beziclan can cause a dose-dependent suppression of Na + / K +-dependent ATPase and aggregation of platelets and erythrocytes, as well as an increase in the elasticity of red blood cells. These effects are observed mainly in peripheral vessels, coronary arteries and brain vessels.
In addition, the beziclan has a spasmodic effect on visceral muscles (gastrointestinal tract, urinary tract, respiratory organs).
The drug causes some increase in heart rate. It also knows its weak tranquilizing effect.

Pharmacokinetics

Suction
After taking the drug inside, the bencyclane is absorbed from the gastrointestinal tract quickly and almost completely. Cmax in the blood plasma is achieved after 2-8 hours (usually after 3 hours) after intake. Due to the effect of "first passage" through the liver, the bioavailability of the drug after intake is 25-35%.
Distribution
Approximately 30-40% of the amount of bentheclane in circulating blood is associated with plasma proteins, 30% with red blood cells, 10% with platelets; The free fraction is 20%.
Metabolism
Metabolism is carried out in the liver, mainly in two ways: dealekilization gives a demethylated derivative, the rupture of the ether communication gives benzoic acid, which in the future turns into hypproves.
Election
T1 / 2 is 6-10 hours. It is removed mainly with urine in the form of inactive metabolites, but also unchanged (2-3%). Most metabolites (90%) are excreted in non-conjugated form, and a small part - in conjugated form (approximately 50% in the form of a conjugate with glucuronic acid). The total clearance is 40 l / h, the kidney clearance is less than 1 l / h.
Pharmacokinetics in special clinical cases
T1 / 2 does not change in elderly patients, as well as in violation of kidney and liver functions.

Indications for use

A drug Galidorused in vascular diseases: Diseases of peripheral vessels - Reino disease, other diseases with acricyanosis and vessel spasms, as well as chronic binding diseases of the arteries; Cerebral vessel diseases: in complex therapy of acute and chronic cerebral ischemia.
To eliminate the spasm of internal organs:
- gastrointestinal diseases - gastroenteritis of various etiology (especially infectious), infectious and inflammatory colitis, functional diseases of the thick bowel, tenesms, postoperative meteorism, cholecystitis, bile disease, state after cholecystectomy, motility disorders when the sphincter dubber and duodenal ulcene intestine (in combination therapy);
- Urological syndromes: spasms and urinary bubble tensum, concomitant therapy of urolithiasis (in combination with analgesics with renal colic).
Preparation for instrumental research methods in urology.

Mode of application

Vascular diseases
Inside Galidorassign 100 mg 3 times / day for 2-3 months. The maximum daily dose for intake is 400 mg. The interval between the courses is 2-3 months.
The drug can also be used in the form of a / in infusion in the daily dose of 200 mg, divided into 2 administration. Before carrying out the infusion of 100 mg (4 ml) of the drug is divorced in 100-200 ml of isotonic sodium sodium solution and introduced in / in drip within 1 h 2 times / day.
To eliminate the spasm of internal organs
Inside Galidorprescribed at a dose of 100-200 mg once, but not more than 400 mg / day. For supporting therapy, 100 mg 3 times / day are prescribed for 3-4 weeks, then 100 mg 2 times / day. The duration of treatment is determined individually depending on the disappearance of the symptoms of the disease and, as a rule, does not exceed 1-2 months.
In acute cases Galidorintroduced to / in slowly at a dose of 100-200 mg (4-8 ml) or V / m deep at a dose of 50 mg (2 ml). Before in / in the introduction, the required amount of solution is bred by an isotonic solution of sodium chloride to 10-20 ml. The course of treatment is 2-3 weeks with the subsequent transfer of the patient, if necessary, on the reception of the drug Galidor inside.

Side effects

From the digestive system: dryness in the mouth, pain in the abdomen, feeling of satiety, nausea, vomiting, increasing the activity of hepatic transaminase in serum.
From the CNS: anxiety, dizziness, headache, breach of gait, tremor, sleep disorders, insomnia, memory disorders; rarely - transient matted state of consciousness, epileptiform seizures, hallucinations; In isolated cases, the symptoms of focal damage to the central nervous system.
From the side of the cardiovascular system: sometimes - atrial and ventricular tachyrhythmia (especially with joint introduction with other prohitmogenic drugs).
Others: general malaise, increase in body weight, leukopenia, allergic reactions; Rarely thrombophlebitis with in / in administration.

Contraindications

:
Contraindications for the use of the drug Galidorare: severe respiratory failure; renal failure of severe; severe liver failure; decompensated heart failure; acute myocardial infarction; AV blockade; epilepsy and other forms of spasmodilia; recently transferred hemorrhagic stroke; Card-brain injury (over the past 12 months); pregnancy; lactation period (breastfeeding); Children's and adolescent age up to 18 years old (insufficient use experience); Increased sensitivity to the components of the drug.

Pregnancy

:
These preclinical studies did not reveal any embryotoxic or teratogenic effects, but adequate and strictly controlled clinical studies on the use of the drug Galidorduring pregnancy and during the lactation period was not conducted. Therefore, the introduction of the drug to patients in the first trimester of pregnancy is not recommended.
If necessary, the use of the drug during the lactation period should be resolved about the cessation of breastfeeding during treatment.

Interaction with other medicines

With simultaneous use Galidorstrengthens the inhibitory effect on the CNS tools for anesthesia and sedatives.
With the simultaneous use of Galidore with sympathomimetics, the risk of developing tachycardia, atrial and ventricular tachyarhythmias increases.
With the simultaneous use of Galide and preparations that reduce the level of potassium in the blood (including diuretics, heart glycosides), and quinidine is possible the sum of the pro-limmodogenic effects.
With the simultaneous use of Galidera with drugs, the risk of arrhythmia in the overdose of cardiac glycosides increases.
With the simultaneous use of Galidera with beta-adrenoblockers, it may be necessary to select a dose of beta-adrenobloclater due to the opposite of chronotropic effects (negative in beta-adrenoblasts and positive at bentheclan).
With the simultaneous use of Galidera with calcium channel blockers and other antihypertensive preparations, there is a strengthening of their effect.
With the simultaneous use of Galidera with drugs causing side effects in the form of spasofiliilia, the sum of these effects is possible.
With the simultaneous use of galide with acetylsalicylic acid, it is possible to strengthen the braking aggregation of platelets.

Overdose

:
Symptoms overdose Galidor: Increase in heart rate, decreased blood pressure, collapse, renal function disorder, urine incontinence, drowsiness, anxiety, in severe cases - epileptiform convulsive seizures. Significant overdose may cause tonic and clonic convulsions.
Treatment: Conducting symptomatic therapy. When taking a large number of tablets, stomach washing. For the treatment of convulsive seizures, benzodiazepines are recommended. Specific antidote is not known. There are no data on the possible removal of beziclan by means of dialysis.

Storage conditions

A drug Galidorit should be stored in an inaccessible place at temperatures from 15 ° to 25 ° C. The shelf life of the tablets is 5 years. The shelf life of the injection solution is 3 years.

Form release

Galidor -tablets 0.1 g per pack of 50 pieces;
Galidor -ampoules 2 ml of 2.5% solution per pack of 10 pieces.

Structure

:
1 tablet Galidorcontains: Bencyclan Fumarate 100 mg.
Auxiliary substances: Potato starch, polyvinyl acetate, magnesium stearate, carbomer 934 p, sodium carboxymethyl starch (type A), silicon dioxide colloidoid, talc.
1 ml 1 ampoule galidorcontains: Bencyclan fumarate 25 mg 50 mg.
Auxiliary substances: sodium chloride for parenteral dosage forms - 8 mg, water d / and - up to 2 ml.

Additionally

:
With simultaneous appointment Galidorawith preparations causing hypocalemia, heart glycosides, with drugs inhibiting myocardial functions, the daily dose of Galideor should not exceed 150-200 mg.
When parenteral use, the injection sites should be changed, because The drug may cause damage to the endothelium of vessels and thrombophlebitis.
It is necessary to refrain from the parenteral administration of the drug patients with severe cardiovascular or respiratory failure, predisposed to the collapse, as well as with prostate hypertrophy and urine delay (the delay of the delay increases with the relaxation of the muscles of the bladder).
For long use Galidore is recommended systematic (at least 1 time in 2 months) carrying out laboratory studies of the rheological properties of blood.

Main settings

Name:	Galidor
ATH code:	C04AX11 -