Application of ointment aciclovir Akrichin. Acyclovir-acryoine tablets - instructions for use. Impact on the ability to control vehicles and complex mechanisms

19.07.2020 Analyzes

Acikovir-acry: instructions for use and reviews

Latin name: Acicalovir-akri.

ATX code: D06BB03

Active substance: Acyclovir (aciclovir)

Manufacturer: OJSC Synthesis, OJSC Akrikhin, OOO Ozone, OOO Alvs, OAO TatchimfarmPreparats, ZAO Altaivitamans, OAO NFIFARM, ZAO Vertex, RUE Belmedpreparata (Russia); ASTRAFARM, OOO, OOO Darnitsa, PJSC Pharmak, OOO Farmex Group (Ukraine)

Actualization of the description and photo: 22.10.2018

Acyclovir-acry - antiviral drug.

Release form and composition

Medicinal forms of acyclovir-acry:

tablets (10 pcs. In the contour cellular packaging, in a cardboard pack 2 or 3 packs; 20 pcs. in a glass can of dark color, in a cardboard pack 1 bank);
ointment for outdoor use 5% (2, 3, 5, 10 or 30 g in aluminum tube, in a cardboard pack 1 tube);
cream 5% (2, 5 or 20 g in tube, in a cardboard pack 1 tube).

The active ingredient of acyclovir-acry - acyclovir:

1 Tablet: 0.2 g, 0.4 g;
1 g ointment: 0.05 g;
1 g of cream: 0.05 g

Pharmacological properties

Pharmacodynamics

Acyclovir is a synthetic analogue of acyclic purine nucleoside, has high degree selective action for herpes viruses. The reactions of the transformation of acyclovir in the mono-, di- and trifhosphate of the acyclovir consistently occur under the action of viral thymidicinase inside the cells infected with the virus. After that, the acyclovir trifhosphate is embedded in a chain of viral DNA (deoxyribonucleic acid) and through competitive inhibition of viral DNA polymerase blocks its synthesis.

In vitro has an acyclovir activity with respect to the VARICELLA ZOSTER virus, Herpes Simplex (type 1 and 2) and in higher concentrations - Epstein Virus - Barr.

In vivo Therapeutic and prophylactic effect of acyclovir is confirmed in relation to viral infections caused by Herpes Simplex.

Aciclovir-acry prevents the formation of new elements of the rash, reduces the likelihood of the propagation of the skin causative agent of the disease and visceral complications, accelerates the process of formation of the crust, contributes to the weakening of the pain in the acute phase of herpes sheeping.

Pharmacokinetics

When taking inside the acyclovir-acry tablets, the drug absorption in gastrointestinal is 20%. There is a relatively weak binding of acyclovir with plasma proteins.

The average half-life is 3 hours.

IN spinal fluid The concentration corresponds to 50% of the blood plasma level. In the process of biotransformation of acyclovir, 9-carboxymetoxymethylguanine is formed.

A 10-15% of the drug in the form of a metabolite or unchanged form is displayed through the kidneys.

Indications for use

skin infections and mucous membranes caused by the Herpes Simplex virus (type 1 and 2), including primary and secondary genital herpes;
primary and recurrent infections caused by the VARICELLA ZOSTER virus (slimming, chickenpox);
pronounced immunodeficiency after transplantation bone marrow and with HIV infection (early clinical manifestations, AIDS stage, deployed clinical picture) - as part complex therapy;
prevention of primary and recurrent infections caused by the Herpes Simplex virus (type 1 and 2) in patients with immunodeficiency;
prevention of exacerbations of recurrent infections caused by the Herpes Simplex virus (type 1 and 2) in patients with normal immune status.

Contraindications

pregnancy period;
breast-feeding;
hypersensitivity to gancyclovir and drug components.

Caution should be prescribed acyclovir-acry in neurological disorders (including history), dehydration, renal failure.

Instructions for the use of acyclovir-acry: method and dosage

Pills

Aciclovir-acry tablets are accepted inside during or immediately after eating, drinking sufficient water.

Dosing mode prescribes the doctor individually taking into account clinical Indications and the severity of the patient's condition.

treatment of skin infections and mucous membranes caused by the Herpes Simplex virus (type 1 and 2): Patients over the age of 2 years - 0.2 g 5 times a day (every 4 hours during the day and with an interval at 8 o'clock at night) . The duration of the course is 5 days, if necessary, treatment can be extended;
pronounced immunodeficiency, including deployed clinical picture HIV infection (including early manifestation of HIV infection and AIDS stage), after bone marrow transplantation (as part of comprehensive therapy): 0.4 g 5 times a day;
prevention of recurrence of infection caused by the Herpes Simplex virus (type 1 and 2) in patients with normal immune status: 0.2 g 4 times a day every 6 hours;
prevention of infection caused by the Herpes Simplex virus (type 1 and 2) in patients with immunodeficiency over 2 years: 0.2 g 4 times a day (with an interval of 6 hours), maximum daily dose - 0.4 g 5 times per day;
treatment of infections caused by VARICELLA ZOSTER virus: adults and children with a body weight of more than 40 kg - 0.8 g 5 times a day (every 4 hours during the day and 8 hours at night). Course duration - 7-10 days. Children over 2 years old - at the rate of 0.02 g per 1 kg of body weight 4 times a day. Course treatment - 5 days;
herpes Zoster: Adults and children over 6 years old - 0.8 g 4 times a day (with an interval of 6 hours) for 5 days. Children 2-6 years old - 0.4 g 4 times a day. Children under 2 years old - 0.2 g 4 times a day. An individual dose of the drug can be more accurately determined using the calculation of 0.02 g per 1 kg of the patient's weight. Maximum daily dose - 3.2 g. The course of treatment is 5 days.

With the average and severe degree of violations of the kidney function, a decrease in the daily dose of the drug is required.

Outdoor ointment application 5% and 5%

The preparation in the form of cream and ointments acyclovir-acry is designed for external use by applying a thin layer to the affected area of \u200b\u200bthe body surface.

Side effects

from the central nervous system: rarely - weakness, headache; Individual cases - drowsiness, increased fatigue, dizziness, hallucinations, tremor;
from side digestive system: rarely - transient increase in liver enzyme activity, hyperbilirubinemia; individual cases - nausea, abdominal pain, vomiting, diarrhea;
from the side of the blood formation system: rarely - erythroaction, leukopenia;
allergic reactions: skin rash;
others: Rarely fever, alopecia, an increase in the level of concentration of urea and creatinine in the blood.

In addition, on the background of the use of ointment, the development of the following undesirable effects is possible:

allergic reactions: rarely allergic dermatitis;
local reactions: tingling or burning, redness, itching, peeling skin.

Overdose

Symptoms of overdose are not installed.

special instructions

During the reception period of acyclovir-acry, the patient should drink a sufficient amount of fluid to ensure the organism of the mode of increased hydration. Careful control of the function of the kidneys, blood urea level and blood plasma creatinine is required.

Conducting multiple treatment courses in immunodeficiency patients may cause the formation of virus stability to the active component.

Ointment acyclovir-acry can not be applied to mucous membranes, including genitals, oral cavity and eyes, as this can cause the development of pronounced local inflammation.

Application of ointments should be started when the first symptoms of the disease appears, it increases it therapeutic effect.

Impact on the ability to control vehicles and complex mechanisms

During the period of treatment, caution should be taken when performing potentially dangerous species activities, including management vehicles and mechanisms, since there is a risk of developing unwanted phenomena from the nervous system.

Application during pregnancy and lactation

The drug overcomes the hematoplazent barrier, so applying it during pregnancy is contraindicated.

Appointing acyclovir-acry during the period of tooling is possible only in a special case when, according to the doctor, the expected clinical effect of the therapy for the mother exceeds a potential threat to the fetus.

Since the acyclovir is distinguished with breast milk, the use of the drug during lactation is contraindicated.

With violations of the kidney function

According to the instructions, acyclovir-acry with caution must be used in the treatment of patients with renal failure.

Acyclovir-Akrikhin - drug Treatment Antiviral action for internal (tablet) and outdoor (ointment) application.

Release form and composition

Acricovir-acryer is available in the following forms:

tablets: flat-cylindrical, blue with darker and brightened splashes and sometimes white spots, with risks on one side and fist (10 pcs. in blisters, in the carton 2 blister and instructions for the use of the drug);
outside application ointment 5%: white or almost white homogeneous mass, the presence of characteristic odor is allowed (2, 3, 5 or 10 g in aluminum tubes, in cardboard package 1 tube and instructions for the use of acyclovir-acryoine).

Composition on 1 tablet:

active Component: Acyclovir - 200 mg or 400 mg;
auxiliary components: magnesium stearate, sodium carboxymethyl stroke, microcrystalline cellulose, indigormin, poverant, purified water.

Composition on 1 g of ointment for outdoor use:

active Component: Acyclovir - 50 mg;
auxiliary components: Vaseline oil, polyethylene oxide 1500, propylene glycol, emulsion wax, vaseline, purified water.

Pharmacological properties

Pharmacodynamics

Aciclovir-acryoine - antiviral agent; It is a synthetic analogue of an acyclic purine nucleoside, which is highly elected against herpes viruses.

The mechanism of action of the drug is as follows: acyclovir penetrating into infected cells containing viral thymidicinase, phosphorylated and converted into acyclovir monophosphate. Then, under the influence of the enzyme guanillates of acyclovir, monophosphate turns into dyphosphate and further (under the influence of a number of cell enzymes) - in trifhosphate. After that, the acyclovir trifhosphate begins to integrate into the DNA of the virus and blocks its synthesis due to the competitive inhibition of the DNA polymerase of the viral cell. High selectivity of action and specificity are also due to the fact that acyclovir accumulates mainly in cells affected by herpetic infection.

Acyclovir-Akrichin is highly active against the VARICELLA ZOSTER (a virus causing a sinking deck and windshield OSP), Herpes Simplex 1 and 2nd types and herpes virus of the 4th type (Epstein Virus - Barr). Acyclovir has moderate activity against cytomegalovirus.

In herpes, acryochin acryochine helps to prevent the appearance of new elements of rash, reduces the risk of defeat internal organs and skin dissemination reduces painfulness In the acute phase of slaughtering linguing, speeds up the process of formation of the crust.

Pharmacokinetics

Acyclovir bioavailability oral use ranges from 15 to 30%. It penetrates all the fabrics and organs; In the spinal fluid, its concentration is 50% of the plasma. The acyclovir passes through placental and blood-brain barriers, penetrates breast milk. Plasma proteins are binding from 9 to 33% of the active substance.

The maximum plasma concentration of acyclovir after receiving 200 mg of the drug is 0.7 μg / ml. To achieve this indicator requires 1.5-2 hours.

Metabolism occurs in the liver. As a result, a pharmacologically inactive 9-carboxymetoxymethylongan is formed. When taking inside the half-life is 2-3 hours. In patients with severe renal failure, it is lengthened to 20 hours, and in patients on hemodialysis - up to 5.7 hours (the plasma concentration of acyclovir decreases to 60% of the initial value).

In unchanged form, about 84% of the drug is derived and approximately 14% - in the form of a metabolite. The main way of removal - through the kidneys; Less than 2% of acyclovir is excreted with the feces; Track quantities were determined in exhaled air.

In the external use of acyclovir-acryoine (in the form of ointments), absorption of acyclovir on intact skin sites is minimal; It is not determined in the urine and blood. If the skin is amazed, then the suction is moderate. The serum concentration of aciclovir is up to 0.28 μg / ml in persons with normal kidney function and up to 0.78 μg / ml - in patients with chronic renal failure. Up to 9.4% of the daily dose of the drug is derived from the urine (through the kidneys).

Indications for use

Tablets aciclovir-acryochin are used to prevent or treat the following diseases:

treatment of recurrent and primary infections caused by the VARICELLA ZOSTER virus (listened, chickenpox);
prevention of recurrent and primary infections caused by herpes viruses 1 and 2nd types (Herpes Simplex) in patients with immunodeficiency;
prevention of relapses of infections caused by herpes viruses 1 and 2nd types (Herpes Simplex) in persons with normal immune status;
treatment of primary and secondary infections of mucous membranes and leather caused by herpes viruses 1 and 2nd types (Herpes Simplex), including genital herpes;
complex therapy of pronounced immunodeficiency (patients with HIV infection and patients undergoing bone marrow transplantation).

Ointment aciclovir-acryoin is used externally under the skin manifestations of a wind sip, slimming, genital herpes and skin infections caused by Herpes Simplex types 1 and 2.

Contraindications

Absolute contraindications for the preparation of tablets:

children's age under three years;
breastfeeding period;
hypersensitivity to valciclovir, gancyclovir, acyclovir, or auxiliary ingredients of the drug.

Relative (acrylochin tablets are used with caution):

renal failure;
dehydration;
neurological disorders or neurological reactions to cytotoxic drugs (including a history of history);
elderly age;
pregnancy period.

Ointment acyclovir-acryoine is contraindicated with patients with hypersensitivity to the main or auxiliary components. The preparation in the form of ointments is used in patients with renal failure, dehydration, as well as in pregnant and nursing women.

Acyclovir-Acryich: Instructions for use (dosage and method)

Pills

In the form of Tablets, acyclovir-acryin is taken inside, during or immediately after eating. The drug should be piled by water.

The dosing mode is individual and depends on the severity of the underlying disease.

treatment of linguing: 800 mg 5 times a day (every 4 hours during wakefulness, except for night sleep), the duration of the course is 7-10 days;
prevention of infections caused by herpes viruses 1 and 2nd types in patients with immunodeficiency: 200 mg 4 times a day (every 6 hours); maximum dose It is up to 400 mg of the drug 5 times a day (depending on the severity of infection);
prevention of recurrence of infections caused by herpes viruses 1 and 2nd types in persons with normal immune status: 200 mg 4 times a day every 6 hours, the duration of the course is from 6 to 12 months;
treatment of primary and secondary infections of mucous membranes and skin caused by herpes viruses 1 and 2nd types: 200 mg 5 times a day (every 4 hours, except for night sleep), the duration of the course is 5 days (with genital herpes - 10 days ) or more if necessary;
complex therapy of pronounced immunodeficiency (patients with HIV infection and patients who have undergone bone marrow transplantation): 400 mg 5 times a day.

With a wind inspection with children aged 3 to 6 years old, 400 mg of the drug are prescribed 4 times a day, and for adults and children over 6 years old - 800 mg 4 times a day. The exact dose is determined at the rate of 20 mg per kg of body weight. The duration of therapy is 5 days.

In patients with impaired kidney function, the Acyclovir-Akrichin dose is adjusted depending on the type of infection and the value of the clearance of creatinine. With infections caused by Herpes Simplex and creatinine clearance less than 10 ml / min, the dose should be reduced to 400 mg per day in two receptions (the interval between the receptions should be at least 12 hours). The daily dose of the drug for patients with pronounced immunodeficiency (as supporting therapy) and chickenpox or a wedding of creatinine clearance less than 10 ml / min is 800 mg 2 times a day (with an interval of at least 12 hours), and with creatinine clearance 10 -25 ml / min - 800 mg 3 times a day (with intervals between at least 8 hours).

Outdoor ointment

Acrichin acryochin in the form of ointments is used externally. The drug is applied by a subtle layer every 4 hours (5 times a day) on the affected skin, as well as areas bordering it. You can use a cotton swab or apply your ointment with your hands (pre-washed).

The treatment continues to form a crust on bubbles or to their complete healing. On average, the course lasts 5 days. The maximum duration of therapy is 10 days. If there is no effect on treatment, you should consult a doctor.

Side effects

Possible side effects Acyclovir-Akrichin when taking inside (in the form of tablets):

gastrointestinal tract: abdominal pain, nausea and vomiting, liquid chair; rarely - reversible increase in the activity of liver enzymes and bilirubin levels;
central nervous system: weakness, drowsiness, increased fatigue, headache, decreased concentration, dizziness, confusion, emotional arousal, convulsions, feeling of numbness in limbs, hallucinations;
urinary system: rarely - improving the level of creatinine and urea in blood plasma; very rarely - acute lack of kidney function;
blood-formation system: very rarely - a decrease in leukocytes and platelets, anemia;
allergic reactions: urticaria, itching, rash on the skin, swelling of quinque, multiform exudative erythema, Lyleel syndrome, anaphylactic shock;
other reactions: muscle pain, fever, peripheral swelling, violation of vision, pathological hair loss, increase lymph nodes.

With external use, side effects from the skin and subcutaneous fabrics may occur: dry, redness and peeling of the skin, a feeling of burning. Perhaps local inflammation (if the ointment fell on the mucous membranes), as well as the development of allergic dermatitis.

Overdose

In case of overdose of acyclovir (after intake), such symptoms are observed as emotional excitement, lethargy, convulsions and coma. It is possible to precipitate aciclovir in the renal tubules, if its content is more than 2.5 mg / ml, which is above the solubility threshold.

With the external use of acyclovir-acryoine cases of overdose noted.

special instructions

Pills

During treatment, it is necessary to control the level of creatinine and the urea content in the blood. The patient must receive a sufficient amount of fluid.

With prolonged or repeated therapy with acyclovir in patients with reduced immunity, the appearance of insensitive acyclovir-acryoine strains of viruses is possible. Most of these strains found a relative lack of the enzyme of the thymidicinase; Also the strains of viruses with a changed DNA polymerase or altered thymidicinase were also allocated.

Acyclovir-Akrichin does not protect against the transfer of herpes by sexually, so during treatment it is necessary to refrain from sexual bonds, even if the clinical manifestations are absent.

Outdoor ointment

The maximum therapeutic effect is achieved if the treatment of the drug is started as early as possible. Ointment should be used immediately after the emergence of the first signs of the disease (itching, burning, tingling, redness and feeling of tension).

Acrylo-acryochin can not be applied to mucous eyes and oral cavitySince there may be pronounced local inflammation.

In the treatment of genital herpes, it is necessary to abandon sexual contacts or use condoms during this period, since the acyclovir does not protect against the transmission of the virus sexual.

Impact on the ability to control vehicles and complex mechanisms

Patients who undergo a course of treatment with acrylo-acryo-form in the form of tablets must be careful when managing vehicles and performing other works requiring special concentration of attention and rapid response.

Application during pregnancy and lactation

During pregnancy, acyclovir should be used with caution and only in those situations where the benefits of treatment for the mother above possible risk For fetal.

Tablets aciclovir-acryoin are contraindicated with nursing women. Outdoor ointment can be used during lactation, but with caution.

Childcare

Acriclovir-acryoine in the form of tablets is contraindicated to children under three years.

With violations of the kidney function

Acriclovir-acryer with caution is used in patients with renal failure.

Application in old age

In senior patients, acryochin acryochin is used with caution.

Medicinal interaction

The probenecid increases the average half-life and reduces the Clearance of acyclovir.

For sharing With nephrotoxic agents, the likelihood of a disturbance of the kidney function increases.

Acrichin acrylo in the form of ointments does not interact with other drugs, but the simultaneous use of immunostimulants enhances the effect of the drug.

Analogs

Analogues of Acyclovir-Akrichin are tablets: Acyclovir-Belupo, Acyclovir Forte, Acyclovir-AKOS, Acyclovir-SZ, Acylostad, Vivorax, Herperics, Zovirax, Provirsan; Ointment and creams: Acyclovir-Belupo, Acyclovir Sandoz, Acyclovir-Fereyn, Vivorax, Virolex, Gerlor, Gerpex, Zovirax.

Terms and conditions of storage

Store in an inaccessible for children, dark and dry place at a temperature of not more than 25 ° C.

Shelf life: Tablets - 4 years, Outfolding Ointment - 3 years.

Conditions of vacation from pharmacies

Tablets are released by the recipe, ointment ointment - without a recipe.

Skin lesions are one of the most unpleasant diseases, and not so much due to pain, as because of the aesthetic discomfort, which they deliver "owners". The complexity of the situation is that the patients have to live with this unpleasant ailment of all life. Hide it from prying eyes is extremely problematic, especially during periods of exacerbations. But the one who is looking for will always find a way out even from the most difficult situation.

One of the ways to solve many dermatological problems, including those provoked by the herpes virus, will be offered in today's article. To be more accurate, then in the material it is proposed detailed instructions Under the use of ointment Acyclovir Akrichin; Its composition, properties, indications for use, possible side effects, analogues and price.

If you are not acquainted with infectious skin lesions, do not waste time in vain!

Ointment refers to a large group of antiviral drugs. Its maintenance is the suppression of pathogenic activity of herpesviruses during the weakening of immunity, protective functions of the body. The application is shown early stages HIV infection. In the external use of ointment, it is possible to promptly localize the problem area, eliminate pathogens of microorganisms.

Mechanism of transmission of genital herpes (WSV-2) We are talking about a medicinal "preventive strike" by fear:

viruses do not have time to spread to healthy cells;
the danger of relapse is leveled.

The feature of the liniment is that it is not absorbed by the mucous membranes of the oral cavity, therefore is suitable for outdoor lip processing. Treatment of diseases involves an integrated approach: the drug is complemented by injections of vitamins, synthetic glycoproteins. Patients with reduced immunity: after transplantation of organs, bone marrow, with AIDS, the system therapy is shown.

Pharmacological group and action

Acyclovir Akrikhin is one of the most striking representatives of antiviral funds. This is an artificially synthesized substitute for purine nucleoside acyclic type, a characteristic feature of which is a narrow-controlled impact on pathogenic herpes (Herpes Simplex and Varicella Zoster). The active substances of the medication prevent the reproduction of causative agents of infectious ailments.

The line removes the painful sensations during the exacerbation of the herpes of the herpes, contributes to the acceleration of the formation of the epithelial crust in the damage zone.

What is due high efficiency Antiviral drug for outdoor use?

Acyclovir accumulates in cells infected with the virus.
In the pathogenic microflora, the active substance turns into monophosphate, then in the diphosphate and at the final stage - in trifhosphate.
This substance inhibits the DNA polymerase of the virus, due to the integration into the DNA structure.
Alien viral structure is destroyed at the cell level.

It has been established that acyclovir demonstrates high activity in relation to the Epstein-Barr virus, but provided high concentration active substances. Reaffirmed moderate activity against cytomegaloviruses.

Release form, composition and packaging

Acyclovir Akrichin ointment 5% suggests that 100 g of the liniment accounts for no more than 5 g of the active element (acyclovir), because this designation has been widely popular. As auxiliary components, reinforcing the main action, are:

Ointment has an average of white-colored consistency. Available in aluminum tubes. The drug is available on sale in different tubes - by 2, 3 and 5 g. Packaging - a dense cardboard, the standard configuration provides an abstract to a medicine, instructions for use.

Terms and Storage Terms

According to the information provided by the company by the manufacturer, the shelf life of Mazi is no more than 3 years from the date indicated on the package. Opening tube automatically reduces the specified value to 1-1.5 months. Medical properties The medication corresponds to the declared only, provided that the temperature of the storage does not exceed the value of + 25 ° C.

The ointment of the acyclovir should be stored in the place specifically allocated for medicines. Ideal in the refrigerator

If, after opening the tube, the composition was in close proximity to the source of humidity, in contact with the solar rays, changed according to the consistency or acquired an uncharacteristic smell, it is better to refuse it from its subsequent use.

Instructions for use

In accordance with the recommendations presented in annotations to the drug, the oceavine composition is applied with clean hands (treated with antiseptic), or use sterile cotton balls for this purpose. Pre-affected and bordering areas of the epidermis are neatly treated with chlorhexadine, in order to level the risk of penetration into infection wounds.

Ointment acyclovir Akrichin is applied to the affected areas with a sterile cotton disk or clean hands Ointment is applied only externally, on an affected area:

1-2 g medicinal composition apply to the surface of the epidermis;
dense consistency are evenly distributed on the processed zone;
the processing frequency is 4-5 times a day with an interval of 4 hours except for sleep.

The impact on the pathogenic microflora is starting as early as possible after infection. The duration of the course is 5 days, but not more than 10. If a crust is not formed on the surface of the bubbles after 10 days, we recommend to seek help to the doctor.

Indications for use

What is the ointment of Acyclovir Akrichin? "The question is asked by most patients, since it is a large family of antiviral agents. Below is a list of diseases and pathologies, when diagnosing which the doctor assigns a line.

Ointment Acyclovir Akrichin helps to cope with any kinds of herpes

Herpetyiform sputters of one-sided type on the surface of the epidermis, accompanied by severe painful sensations (Herpes Single).
Infectious lesions of the skin caused by the activity of HPV (in 80% of Patients HVV 2 type).
Chickenpox.
Herpes genital type.

Previously, you must consult a doctor for exception. side Effects.

Contraindications and side effects

The feature of ointment Acyclovir Akrichin is that it is practically not absorbed through the skin, i.e. Absorption tissues minimal. Due to the specified property, the pharmaceutical agent has almost no contraindications. As an exception, the individual intolerance to the patient of the existing elements of the composition (both basic and auxiliary), increased susceptibility to them.

During pregnancy to use ointment acyclovir Akrichin is strictly prohibited With caution and under the supervision of the doctor, the use of the following patients is allowed:

women during pregnancy;
pronounced dehydration of the body;
renal failure in chronic or acute form;
breastfeeding of a child (a local treatment with short courses is allowed during lactation).

Listed patients is important to observe the doctor during the entire period of therapy, as well as 3-4 days after the end of treatment.

Possible side effects:

The above reactions pass 4-6 hours after 4-6 hours and do not require treatment of medical insurance.

Medicinal interaction

Confirmed official data on the interaction of ointments drugs not. It is possible to predict the increase in the effectiveness of the medication, subject to the simultaneous use of immunostimulants. In the appointment of the doctor can be combined with antibacterial compositions.

Method of application and dose

Antiviral ointment acyclovir is applied externally. It is applied with clean, processed antiseptic, arms or sterile cotton swabs. It is advisable to clean the local area to the local area on which the line is planned to be applied to chlorhexadine or Mirismine.

Dosage of ointments to each patient determines and prescribes a doctor

The drug applies only point, medium thick consistency is evenly distributed over the affected skin. The frequency of repetition of the procedure is 1 time with an interval of 4 hours, but not less than 5 times a day. Adult doses sets the attending physician. With independent use, the average dose should not exceed 1.5 cm long by 25 cm2 (if you pledge an analogy with a strip).

Precautions

Despite the absence of contraindications, specialists allocate a number of precautions that deserve special attention when applying the medication.

Women in the position should remember - acriclovir Akrichin is not used when carrying a child.

Conditions of vacation from pharmacies

The antiviral agent under consideration is officially permitted for use without a recipe, from pharmacies is released freely.

Cost of preparation

In Moscow, the price of ointment acyclovir Akrichin varies in the range from 37 to 80 rubles. In the regions, the cost of the medication is often higher by 20-50%.

Analogs

In cases where the acyclovir does not help, you need to contact the doctor to appoint a substitute. Analog pharmaceutical preparation are: Arviron, HoroPorm, Valtarex, Minker, Trivorin, Viru Merz, Herpferon, etc.

Acyclovir Akrichin Ointment (Review) from 38 rubles

Description

Antiviral drug. Well suitable for treating herpes.

Overall

4.7

Efficiency
Price

Acyclovir-Acryikhin refers to antiviral tools And it is used to treat infectious lesions of the skin caused by the herpes virus (Herpes Simplex) 1 and 2 types. The active ingredient of the drug - acyclovir - is practically not absorbed by the mucous membranes and is not determined in serum and urine. This refers to the case when the ointment was applied to intact (intact) skin. If the processing was performed on damaged areas, the moderate concentration of the active component is determined in liquid structures.

Release form and composition

Ointment "Acyclovir-Acryikhin" is available in aluminum tubes with a volume of 2 g, 3 g and 5 g. The drug has a homogeneous dense texture of white color with a characteristic odor.

The amount of acyclovir in 100 g of ointment is 5 g, so the ointment has a 5% concentration.

In addition to acyclovir, the production of "aciclovir-acryoine" is used by excipients:

vaseline and vaseline oil (for consistency);
emulsion wax;
propylene glycol;
macrogol;
water special cleaning.

The presence of auxiliary substances should be taken into account patients with various forms Allergies (including medicinal).

When is it assigned?

Acyclovir is active in relation to herpes virus, therefore, the ointment is prescribed for external use in infectious lesions of the skin and mucous membranes (especially exposed to the infection of the lip). Active Component The drug penetrates the changed structure of the skin at the cellular level and destroys the virus by blocking its activity and distribution. Indications for the use of ointment "aciclovir-acryoine" are:

infectious diseases of the skin and mucous membranes arising from the infection with the herpes virus (1 and 2);
genital herpes;
chickenpox;
lained zone type.

Important! It is impossible to assume funds in the mouth, therefore "acrylovir-acryoch" is not suitable for processing ulcers on the mucous membranes of the oral cavity.

How to apply?

Instructions for use of ointment recommends applying tools with hands or cotton disk. If wool is used for processing, it is better to purchase special sterile cotton balls. If the ointment is applied with his hands, it is important before the start of the procedure to wash them with antibacterial soap. It is possible to further treat the skin with an antiseptic solution (for example, "chlorhexidine"). It is necessary in order to prevent dirt and bacteria from entering bubbles and blisters and not to develop a secondary infection.

Ointment "aciclovir-acryochin" is used for local processing of amazed skin (only external) in the following way:

a small amount of means to inflict on the affected area;
distribute the drug throughout the infected surface with a thin layer;
conduct 5 times a day every 4 hours (excluding night sleep time).

The duration of treatment is 5-10 days. It is necessary to use ointment until the bubbles are frozen (cover with a crust) or they will not pass at all.

Important! If the therapy does not give a positive result, it is necessary to urgently consult a doctor and go through a comprehensive examination.

When can not be applied?

Ointment "Acyclovir-Acryikhin" under local use is practically not absorbed into blood, therefore this method of use does not have contraindications for use except in cases of increased sensitivity or intolerance of the active substance / additional ingredients of the drug.

Increased caution should be exercised when prescribing medication to patients who identify the following states:

pregnancy;
dehydration of the body;
breastfeeding period;
renal insufficiency of chronic and acute type.

special instructions

Begin the treatment of ointment "aciclovir-acry" needed when the first symptoms of the disease appears. With a protracted flow, a decrease in the effectiveness of the drug is possible.
With genital herpes, condoms should be used for the entire treatment period to prevent partner infection. The best way - Abandon sexual proximity at all until complete recovery comes.
Treatment with acyclovir-based drugs must be accompanied by sufficient consumption of pure water.
It is impossible to make funds in the mouth and eyes. The contact of the acyclovir with thin mucous oxides and eyes can cause severe local inflammation.

Side effects

"Acryl-acry" when external use can cause adverse reactions And allergies. Most often in patients arise:

allergic dermatitis;
burning;
strong itching;
peeling of skin cover;
inflammatory reactions in contact with mucous membranes (for example, when the means in the mouth is hit).

In some cases, a slight increase in temperature is possible. If the thermometer does not exceed 38 degrees, take the antipyretic drugs and seek help in the hospital.

If the ointment got into the mouth

Despite the fact that the instruction recommends avoiding Mazi getting into the mouth. Sometimes it happens that one careless movement leads to the fact that a small amount of the drug turns out to be in the oral cavity. What to do in this case? The answer is nothing. If a small amount of ointments hit the mouth (not to notice it is impossible, since the tool has a very bitter taste), and after some time the patient has no signs of inflammation, do not need special measures. It is quite often ringed with the mouth with water or decoction of chamomile and increase the amount of fluid from the drink.

Contact your doctor in the following cases:

blelerant wounds appeared on the mucous membrane of the oral cavity;
in the mouth there was a feeling of burning, which does not pass after abundant rinsing with water;
the plots of mucosa inflamed and became painful (painfully discover the mouth, drink, talk).

Ointment "Acyclovir-Akrikhin" - effective tool For the treatment of herpes, which has been applied for several decades. Subject to safety measures, the use of the drug does not cause unpleasant sensations and does not cause side effects, therefore the tool refers to a group of selection preparations to eliminate herpetic lesions from various categories of patients.

Last update of the description by the manufacturer 06/17/2004

Filtered list

Active substance:

ATX

Pharmacological group

Composition and form of release

in the contour cellular package 10 pcs.; In a cardboard pack 2 packs.

in tubes of 5 g; In a pack of cardboard 1 tube.

pharmachologic effect

pharmachologic effect - antiviral.

Under the influence of the thymidicinal is converted into an acyclovir trifosphate, inhibiting DNA polymerase, and competitively replacing deoxyguozine trifosphate in the synthesis of DNA viruses. Renders selective action, active with respect to the virus Herpes Simplex types 1 and 2, VARICELLA ZOSTER, Epstein Virus - Barr.

Pharmacodynamics

It warns the formation of new elements of rash, reduces the likelihood of skin dissemination and visceral complications, accelerates the formation of crusts. Weakens the pain in the acute phase of herpes sheeping.

Pharmacokinetics

The gastrointestinal tract is absorbed by 20%. Relatively poorly binds to plasma proteins. The concentration in the spinal fluid is 50% of the plasma level. When biotransformation, 9-carboxymetoxymethylguanine forms. It is removed with the urine unchanged and in the form of a metabolite (10-15%). Middle T 1/2 - 3 h.

Indications of the drug aciclovir-acryoine

Infections of the skin and mucous membranes caused by a variety of herpes virus (type 1, 2), including primary and recurrent genital herpes, and a virus of a loose-hay; Prevention of skin infections and mucous membranes in patients with reduced immunity.

Contraindications

Hypersensitivity.

Application in pregnancy and breastfeeding

Contraindicated during pregnancy (passes through the hematoplazent barrier). At the time of treatment, it is necessary to stop breastfeeding (penetrate into breast milk).

Side effects

Pills: Rarely - nausea, vomiting, diarrhea, headache, increased fatigue, deterioration of hematological indicators, increase the content of bilirubin in plasma, increasing the activity of liver enzymes, allergic reactions.

Ointment: Rarely peeling at the place of application, local irritation of the mucous membrane, burning, pain.

Interaction

Slobalucid slows excretion.

Method of application and dose

Pills: inside; adults and children over 2 years old in the treatment of herpetic diseases - 0.2 g 5 times a day for 5 days; In immunodeficiency - one-time dose Increase to 0.4 g. To prevent herpetic infections in patients with immunodeficiency - 0.2 g 4 times a day. Infections caused by the virus of the sliding linga - 0.8 g 5 times a day for 7 days. Patients with violations of the kidney function must be adjusted to adjust the dosing mode: CL Creatinine less than 10 ml / min daily dose Reduce up to 0.4 g of 2 receptions with an interval between receivers of at least 12 hours. in the treatment of infections caused by VARICELLA ZOSTER, and supporting therapy of patients with severe decrease in immunity and CL creatinine 10-25 ml / min - 2.4 g / day In 3 receptions with an interval of 8 hours. In patients with Creatinine CL, less than 10 ml / min, a daily dose is reduced to 1.6 g of 2 receptions with an interval of 12 hours.

Children up to 2 years old - half of the dose of adults.

Ointment: Apply a subtle layer on the affected area immediately after the appearance of the first signs of the disease 5 times a day (every 4 hours) within 5-10 days.

Precautions

Caution is prescribed elderly patients, patients with pronounced renal impairments. It is necessary to ensure the mode of increased hydration of the body. Avoid falling ointment on the mucous membranes of the mouth, nose, eye, vagina.