Heptor is a prescription drug (not BAD) for the treatment of liver disease: hepatitis, fatty dystrophy, toxic lesions. A long-term reception rate, so the amount of therapy does not always suit those who need therapeutic effect patients. You should know what to replace heptor, consult with your doctor before making a decision, familiarize yourself with the instructions for use.

The composition includes anemethionine substance, which has the following therapeutic effects:

1. reduces intoxication;
2. restores liver cells;
3. has a choleretic effect;
4. warns fibrosis of the liver, or the growth of connective tissue;
5. protects neurons from death;
6. additional has antidepressive activity.

The medication is available in tablets and injections, more precisely, lyophilisate and solvent. Guptor injections effective tablet As they immediately fall into the bloodstream and have a comprehensive treatment effect. Another advantage of their use is to provide a stable effect with smaller dosages. To renew the course, a tabletic form is used.

Important! When making a recipe in the name, the active substance is written - adhemethionine. This allows you to choose a drug on your own pocket. However, many doctors, knowing the reviews and efficacy of drugs, the recommendations indicate trade names, for example, heptor, heptral.

Indications for the use of heptor

The preparation and analogs in composition (for example, heptral) have medical propertiesTherefore, they are used for diseases and states:

• liver fluid dystrophy;
• states of cirrhosis and precipitation, intrahepatic cholestasis, including pregnant women;
• chronic hepatitis form;
• liver failure, encephalopathy;
• cholecystitis;
• cirrhosis of the liver;
• liver damage to various factors - alcohol, viruses, some medicines, narcotic substances;
• comprehensive treatment Depression.

Heptor - instructions for use

Injections of the drug and structural analogs are prepared immediately before administration by mixing the lyophilisate and solvent. Most effective method - intravenous route of administration. If unavailable, you can use the medicine intramuscularly. At the same time, the medicine is important to introduce very slowly to prevent unwanted reactions.

After treatment with injections, it is possible to extend the course and the appointment of adhemationine tablets, analogue of heptrala. Both forms additionally help against depression and tone the body, so they are not accepted in the evening.

Course treatment, dosage, additional medicines to enhance the effect and prevent unwanted reactions are prescribed by a doctor.

Heptor - how to take before eating or after

The drug and structural analogs (heptral) has a choleretic and hepatoprotective effect, therefore it is accepted in the prescribed dosage (2-4 tablets per day) for half an hour before meals. Other possible variant Reception - 2 hours after meals.

Tablets Heptor 400 mg can not be dissolved and chew. According to the instructions for use, the optimal time for receiving is the first half of the day.

Analogs of heptor

The medication is released on the recipe and is used exclusively for the treatment of liver disease. With a prophylactic goal, analogs can be used. For example, with long-term reception of antiviral drugs, antibiotics, hormonal agents are oppressed by the function of the organ. To protect the liver, restore, reduce the manifestations of intoxication, you can choose in a pharmacy freely implemented, without prescription substitutes.

Analogs of heptor and prices for familiarization (region - Moscow)

Analog	Form release	Price, in rubles	Producing country
	pills	900-1850	Russia
	injection	1100-1500
	pills	1600-2400	Germany, France or Italy
	shows	1600-2100
Samels	pills	800-1100	Russia
Carsil	dragee.	350-800	Bulgaria
Karsyl Forte	capsules	350-500
Legalong	capsules	300-800	Germany
Liv-52.	pills	300-470	India or Russia
Hepatrine	capsules	280-650	Russia
Ovesol	tablets, tea, solution	200-450
Silimar	pills	110-200
	capsules	450-650	Russia
	shows	1250-1650
Phosphoglie Forte	capsules	850-1200
	tablets, capsules	190-3700	Czech Republic
	capsules	540-1600	Spain or Germany
	injection	1100-1350

Carsil

Neckless medical I. preventive tool In case of diseases of the liver - Carsil (35 mg) and the reinforced form of Carsyl Forte (145 mg). The composition contains an extract of a distillation, which has a hepatoprotective, antioxidant, regenerative and disinfective action. Analog inhibits and prevents penetration into the liver toxic substances and cell destruction.

The analogue of the carcilate in the composition is a silmar, containing 100 mg of the extract of milk thistle.

When choosing between a castle or heptor, which is better - depends on the testimony. First tool vegetable originMore often used with a prophylactic goal. The second medication is produced in injections for fast and effective action, Tablets to continue the course. Such a scheme is effective with severe liver lesions.

Legalong

The analogue of the Carsyla Forte and the Karcila in composition (the extract of the milk thistle), contains different doses of the active substance - 70 and 140 mg. German is produced pharmaceutical company. It is prescribed for the treatment and prevention of toxic lesions of the liver - alcoholism, the effects of heavy metals, halogen breeding compounds, some drugs. Released freely, without a recipe.

Samels

Analogue of cheaper - Samels, manufactured by the Russian company of canonfarma in the form of tablets and bottles with lyophilisate and solvent for injection. In its composition, the same substance as in heptor and hepta is admethionine. Possible difference is the manufacturer of the raw material used, the degree of cleaning and technology. The medication is released by the prescription.

Other heptor substitutes (heptrala) with the same composition:

• Heptrazan (Russia);
• Adhemationine (China);
• Geargetta (RF).

Liv 52.

Analogue of Tablets Heptor - Liv 52, unique drug preparation. It contains the extracts of herbs - yarrow, capers, chicory, cassia, faunch and others. Thanks to the incoming elements, the actions:

• prevents the destruction of liver cells toxins;
• knips inflammation;
• improves digestion and learning;
• has anti-diabecable and choleretic properties;
• improves the indicators of blood elements;
• prevents the formation of stones and sand in the gallbladder;
• reduces the risk of "hanging" syndrome;
• with alcoholism improves the withdrawal of acetaldehyde from the body and reduces the risk of liver damage.

Liv 52 is released freely.

Hepatrine

The company Evallar is produced by Bad Hepatrine to maintain the liver and protect the organ from the effects of toxins. The analogue includes extract of artichoke and milk thistle, lecithin, group vitamins V. Doctors are not prescribed, more often used by patients for prophylaxis.

Ovesol

Another analog belonging to the BAA, used to prevent liver lesions - ovesol. Available in the form of tablets, reinforced Oatole form Forte, solution for intake and tea. Contains vegetable components - oats extracts, mint, immortelle and turmeric.

What is better hepta or heptor - the opinion of doctors

Heptral is an original drug based on adhemationine, equivalent to the composition of the heptor. He studied on patients, based on data based on the application to the drug group. This means that this substance, auxiliary components, the technology used gives the results described, have actions, the incidence of unwanted reactions is determined.

Heptor is also created on the basis of adhemationine, is generic or playback. Its effectiveness due to other production technologies, auxiliary substances and used raw materials may differ by 20-25%.

What is better and more efficient - heptor or heptral, opinions of doctors diverge. Some believe that more efficiently imported analog, especially in injections. It should not be prick independently, because There are subtleties (very slow introduction, in the morning). Heptor was not studied on bioavailability or digestibility.

Other doctors are confident that with non-heavy forms of liver diseases, with dissatisfaction with the price, it is possible to choose a heptor with a frequent control of liver indicators, ultrasound.

According to patients reviews when taking an analogue of heptor - hepta less often observed side effects: nausea, pain in the stomach, headache, allergic reactions et al. This indicator of the difference between hepta and heptor is subjective.

What is better - phosphogle or heptor

Phosphoglie is an analogue of heptor and heptrala based on phospholipids and glycyrrizinate. It protects liver cells from destruction. Additionally, antiviral and immunomodulatory action. It is used in lesions of the liver, body fatty organ. Included in the complex treatment of diseases of the skin - dermatitis, dermatosis, eczema, psoriasis. Does not have antidepressive action.

The pharmacies present several forms of the heptor analogue:

• capsules (without recipe);
• reinforced form of phosphogle forte;
• ampoules.

Like heptor, the substitute is used at first if necessary in injections, then for a stable result - in capsules inside.

What is better - heptor or phosphoggy depends on the testimony. Analogue in capsules is available at a price, sold without prescription and can be used for prevention. Other forms of phosphage and heptor are used exclusively by appointing a doctor.

Heptor or Ursosan

Ursosan is an analogue of heptor in 250 mg capsules and 500 mg tablets based on ursodoxicole acid. Sold by recipe. Like the adhemationine, has a choleretic and hepatoprotective effect. Used in the following states:

• chronic hepatitis;
• liver fluid dystrophy;
• cirrhosis;
• other liver diseases.

One of the differences - additional readings to use. Ursosan has a choleretic effect, therefore, it is used in dyskinesia of biliary tract, reflux-esophagitis and bile sickness.

Heptor and Ursosan are absolutely different drugs for the mechanism, excellent in the manufacturer, indications, restrictions, price. The choice between them is carried out in conjunction with the doctor on the basis of the patient's condition, then the recipe is written to acquire in a pharmacy.

What is better - Heptor or Esssential Fort

Essentialy - narrow-plated, safe analogue. It protects liver cells from destruction, restores lost links and reduces the manifestation of intoxication. Produced in capsules and injections. The first form is sold in pharmacies freely, the second is the doctor's prescription.

The counterpart includes phospholipids. They are effective at various lesions of the liver, toxicosis in pregnant women, radiation syndrome, psoriasis. In severe stages of the disease, an injection course is used, then the capsules inside.

Heptor, except for a positive impact on the liver, has a beneficial effect on gall-bubble, suppresses depression. Released exclusively by recipe regardless of the form.

The effectiveness of drugs depends on the testimony. With severe conditions, the doctor is often prescribed heptor.

Heptor, heptales and their analogues - In most cases, prescription drugs for the treatment of liver diseases. If they are assigned, you should consult with the doctor about the safety of replacement by analogs.

Thank you

The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!

Heptral represents drug Treatment From the group of hepatoprotectors with an antidepressant effect. The hepatoprotector has unique properties, such as the ability to improve bile outflow, normalize and improve the functioning of the liver, reduce the degree of damage to its cells in chronic diseases (hepatitis, cirrhosis, etc.) and damage to the organ (medication poisoning, poisons, alcohol, etc. d.), as well as prevent the liver rebirth in connect fabric. The latest heptra's ability - the ability to propagate the rebirth of the liver into the connecting fabric is, in fact, preventing cirrhosis and fibrosis on the background of long-term chronic diseases. Moderate antidepressant effect of the drug is used in the treatment of light psychological disorders.

Forms of release, varieties and composition of heptra

Currently, on the pharmaceutical market there is only one type of drug - heptral, which, in turn, is produced in two dosage forms – pills for intake and lyophilisate For the preparation of a solution for intravenous or intramuscular administration. However, there is still a biologically active additive with a similar name - heptlaight, which is only available in tablets for intake. This biologically active additive should not be confused with the drug, despite the very similar names.

In everyday life, almost no one calls drug forms of the drug completely, preferring to use certain terms and phrases to designate each variant, allowing you to easily recognize this or that form and variety of medication. Thus, heptral tablets are denoted by adding numbers to the word "heptral", reflecting the dosage of the active substance, for example, "heptral 400" or "heptral 400 mg".

For the designation of the lyophilisate for the preparation of the solution for intramuscular and intravenous administration The following terms are used - "Heptral Ampoules", "Heptrale Injection" and "Heptral Pricks". Suite capacious terms allow you to quickly understand what is meant to all participants in conversation - and pharmacists, and doctors, and patients.

The composition of all varieties and dosage forms of hepta as an active substance enters admethionine in different dosages. Thus, heptral tablets contain 400 mg of adhemethionine. The lyophilisate contains 400 mg of the active substance for one bottle.
Heptrala tablets contain the following excipients:

• Silicon dioxide colloid;
• Microcrystalline cellulose;
• Carboxymethyl starch sodium;
• Magnesium stearate;
• Copolymer of methacrylic acid and ethyl acrylate;
• Macrogol 6000;
• Polysorbat;
• Siemeticone;
• Sodium hydroxide;
• Talc;
• Water.

Powder of lyophilisate does not contain any auxiliary components. However, the solvent for lyophilisate in addition to deionized water contains lysine and sodium hydroxide, which are necessary to stabilize the finished solution.

Heptral tablets have an oval, two-way form, covered with an intestinal-soluble shell of pure white or white-yellowish color and are produced in packages of 20 pieces.

Heptral lyophilisate is a white or white-yellow powder without any extraneous inclusions, fastened to glass bottles. Failed ampoules with a solvent are attached to the vials with lyophilisate, which is a transparent liquid of colorless or light yellow. A solution ready for use, obtained by mixing the lyophilisate with a solvent - transparent, painted in colorless or light yellow color, not having a visible precipitate or suspended particles. Heptral for injections is available in packages of 5 bottles with lyophilisate, to which 5 ampoules with solvent are attached.

Therapeutic effects of Heptra

Therapeutic effects of heptrala are as follows:

• Detoxifying effect;
• Halfainetic action;
• Choleretic action;
• Neuroprotective action;
• Hepatoprotective action;
• Antidepressive action;
• Antioxidant action.

All listed therapeutic effects are provided with properties. active component Heptra - adhemationine. This substance is normally produced and is contained in all human cell cells, but its largest amounts are revealed in the brain and liver. That is why heptral has the most pronounced therapeutic effects on the liver and brain.

Hepatoprotective action consists in increasing the stability of the liver cells to various negative factors. Under the influence of hepta, liver cells become stronger and resistant to any damage, as a result of which the functional activity and the structure of the body are improved. In addition, the effect of the drug is improved by the process of growth and reproduction of liver cells, which replace the dead cell elements. The process of substitution of dead cells new, functionally active prevents the development of cirrhosis and liver fibrosis in chronic diseases (cholangitis, hepatitis, etc.).

The choleretic and chopinetic effect consists in increasing the production of bile with the simultaneous intensification of its outflow from the gallbladder in the duodenum. As a result of the choleretic effect, the bile is not stirred in the liver and does not expand its ducts, which contributes to the best functioning of the organ and the prevention of chronic inflammatory process. In addition, the chilestone effect normalizes the bile outflow from the gallbladder, which prevents and eliminates the cholestasis, and also prolongs the duration of the remission period during cholecystitis. Choleretic and chopinetic effects are preserved for at least three months after the cessation of the course of therapy.

The detoxifying effect consists in reducing the development and disposal of various toxic substancesCarried out from outside or synthesized by different organs and tissues. Heptral improves the functioning of the liver, which is much faster and more intensively neutralizes toxic substances than and the detoxification effect is achieved.

The neuroprotective action of heptrala is to increase resistance to negative factors of cerebral cells and nerve fibers. Thanks to this effect, even with severe poisoning and intoxication, encephalopathy is presented. In addition, heptral stimulates the growth and reproduction of nerve cells, due to which the substitution of dead cell elements occurs and fibrosis and sclerosis is propose.

The antioxidant effect consists in increasing the stability of all human cell cells to the damaging effect of free radicals.

An antidepressive effect is developing from 6 to 7 days of treatment and reaches maximum severity by the end of the second week of receiving the drug. Heptral will effectively stop depressions that are not amenable to amitripital therapy and interrupts the recurrences of this disorder.

In osteoarthritis, the drug reduces the intensity of pain and improves the recovery of cartilage tissue. In cirrhosis and hepatitis hepatitis reduces the strength and intensity of the skin, and also supports the level of bilirubin, the activity of alkaline phosphatase, asate, alt, etc. With toxic lesion of the liver (poisoning of poisons, drugs, drug intake, etc.) heptral reduces the phenomena of abstinence ("breaking") and improves the functioning of the organ.

Heptral - Indications for use

Heptral is shown to use in diseases that cause stagnation of bile in the liver, such as:

• Liver fluid dystrophy;
• Chronic hepatitis;
• Toxic liver damage by various factors, such as alcohol, viruses, drugs (antibiotics, antitumor means, antiviral and anti-tuberculosis drugs, tricyclic antidepressants, oral contraceptives);
• Chronic cholecystitis without rock formation;
• Cholangitis;
• Cirrhosis of the liver;
• Cholestasis inholenny (stagnation of bile in hepatic ducts) in pregnant women;
• Encephalopathy associated with hepatic insufficiency;
• Abstinence syndrome (alcoholic, narcotic);
• Depression.

Instructions for use

Consider the rules for use, dosage and therapy scheme with pills and heptrane solution.

Tablets Heptral - instructions for use

Tablets should be taken inside, swallowing entirely, not chewing, not scholating and not shredding in other ways, but drinking a small amount of water. The drug must be taken in breaks between meals, preferably in the morning hours, because heptral has a tonic effect.

You should not pull the pills from the blister in advance and shift into any box or a jar, as it can negatively affect the properties of the drug. Remove the pills from the blister is necessary immediately before receiving.

After the required number of pills is taken out of the blister, you should carefully look at them and evaluate the color. If the tablets are not white or white-yellowish, but painted in any other colors and shades, it is impossible to take them.

In various diseases, heptral should be taken in a daily dosage of 800 - 1600 mg (2 - 4 tablets). Usually, the daily dosage is divided into 2 - 3 receptions per day, the last of which is carried out by a maximum of 18-00 hours. Optimally taking heptral twice a day - in the morning after awakening, and between dinner and dinner.

The duration of the treatment of therapy heptral is individual, and is determined by the doctor based on the speed of normalization of the state. On average, the course of therapy continues from 2 to 4 weeks. Repeated treatment Heptral can be made through the interval of 1 to 2 months after the end of the previous course of therapy.

Instructions for the use of hepta injection (in ampoules)

Packaging for injections Contains bottles with heptrala lyophilisol and ampoules with solvent. It is this attached solvent that should be used to dilute the lyophilisate and obtaining a solution ready for intramuscular or intravenous administration.

With various diseases and pathologies of the liver, heptral is injected intramuscularly or intravenously at 400 - 800 mg per day (1 - 2 lyophilisate vial) daily for two weeks. Then, if necessary, you can continue therapy, going to the reception of heptrala in the form of tablets of 800 - 1600 mg (2 - 4 tablets) per day. The duration of reception of tablets after heptra injections should not exceed 4 weeks.

When depressed heptral is also administered intravenously or intramuscularly at 400 - 800 mg (1 - 2 bottles) per day daily, within 15 - 20 days. After completion of the course, it is possible to continue the heptra in the form of tablets of 800 - 1600 mg (2-4 tablets) per day for another 2 to 4 weeks.

For the introduction of the solution, intravenous injection is preferable compared to intramuscular, since the risk of complications is much lower.

The lyophilisate is always bred by a solvent immediately before administration, and not in advance. Ready solution should be used immediately and not stored even for several hours. If some part of the drug remained after performing the injection, then it must be disposed of, and not to leave until the next time.

Heptral can not be mixed in one syringe or a bottle with solutions containing calcium ions. With other solutions for infusions (for example, glucose, saline, etc.) the drug is compatible.

So, immediately before performing the injection, the solvent from the ampoule should be milled. To do this, the end of the ampoule is inscribed and gently shaped, after which the solvent is gaining a sterile syringe. From a vial with a lyophilisate, an aluminum coating of a soft cover is removed. Then the needle of the syringe with the solvent scored in it is introduced into the vial with a lyophilisate, the pitching soft cover through. The solvent is neatly produced into the vial, not allowing the sharp pressing of the piston so that the particles of lyophilisate do not scatter over the walls. Then, for the complete dissolution of the lyophilisate, without removing the needles, carefully chat the bottle from side to the side, without turning it upwards.

When all the lyophilisate is dissolved, the finished solution should be without impurities and suspended particles and painted in white or white-yellowish color. If there are particles in the solution or its color differs from white-yellowish, then the drug cannot be used, it should be thrown out.

Ready solution, subject to normal external view, dial into the syringe, which is removed from the plug. Then the solution is introduced by the same syringe intravenously or intramuscularly. You can add a solution into the dropper from the syringe and enter the drug in the form of intravenous infusion.

How to enter hepta intravenous (dropper)

An intravenously ready solution of heptrala obtained after dilution of the lyophilisate solvent can be administered in two ways - inkjet or infusion. The inkjet solution is administered unchanged by simply injected it into a vein (as at intramuscular injection). Infusion heptraral is introduced slowly, dropwise, and it is pre-added in 250-500 ml of physiological solution. The infusion administration of hepta is usually called the "dropper", as the drug really gets into a vein dropped.

For the inkjet administration of hepta, the lyophilisate is diluted immediately before performing the injection and dial into the syringe. Then the syringe is put on a thin needle for intravenous injection. Syringe hold B. vertical position The needle up and tapping a finger along the wall towards the needle holder so that all air bubbles accumulate in one place. Then press the syringe piston and produce a small amount of solution, which allows you to remove the air outward.

Next, the skin in the injection area is wiped with a tampon, moistened with an antiseptic, and gently introduce the needle to Vienna. Then the solution from the syringe is slowly introduced (the ampule is introduced at least 2 to 3 minutes). After that, the needle is removed from the vein and again wipe the place of puncture with a swab, moistened with an antiseptic.

For infusion administration, first the lyophilisate in the vial is divorced by a solvent from the ampoule. The finished heptrala solution is poured into an infusion solution. At the same time, the ratio is observed - one fluorite bottle by 250 ml of infusion solution. The infusion solution usually take saline or 5% glucose. The prepared infusion solution is installed in the system and begin to enter 15 - 25 drops per minute.

How to enter heptal intramuscularly

For intramuscular administration of heptrala immediately before performing manipulation, a solvent is lyophilisate. The finished solution is gained into the syringe, they attach a relatively long and thick needle to it, designed specifically for intramuscular injection. Should closely monitor that the syringe does not have a thin needle for intravenous or subcutaneous administration solutions because they can slip from the holder and go into the depths of soft tissues. Such needles that fell into muscles can be in them for years, periodically causing a pain in a person.

After a set of the solution in the syringe, it is held vertically, the needle up, and on the wall slightly tapping a finger in the direction from the piston to the needle, so that air bubbles gathered in one place. Then pressed on the piston, releasing a little solution into the air, which allows you to remove all the gas bubbles of the syringe.

The syringe prepared for the production of injection is laid on a sterile napkin or bandage. Then the injection site is wiped with a tampon moistened with an antiseptic. It is optimally injected into the side upper third of the thigh or in the upper outer third of the shoulder, since in these areas the muscles are close to the skin. You should not enter a solution into the buttock, since the muscles lie deeply and the risk of making subcutaneous injection.

Prepare the injection site, again take the syringe and introduce the needle deep into the tissue vertically to the skin surface. Then slowly pressed on the piston, releasing the entire solution in the tissue. After the introduction of the solution, the syringe is removed, and the injection site is again wiped with a tampon moistened with an antiseptic.

For the production of injection, each time deviates from the previous minimum of 1 cm to minimize the risk of bruising and abscesses.

special instructions

Older people (over 65) are well tolerated heptral, so the dosage reduction is not required. However, elderly people are encouraged to start receiving hepta with minimal dosages, gradually increasing them if necessary.

Against the background of treatment, a person can appear anxiety, which usually passes after a decrease in the dosage of the drug. Such anxiety is not an indication for cancellation of heptrala.

Since heptral has a tonic effect, then you should not enter or take the drug in the evening, shortly before the deposit to sleep.

When using hepta under cirrhosis of the liver, it is possible to periodically determine the concentration of residual nitrogen, urea and creatinine in the blood. Also, on the background of therapy, the drug is recommended to take vitamins of group B, especially in 12 and folic acid, since heptral is poorly absorbed by the lack of specified vitamins.

Do not apply the drug to relieve depression in people suffering from mania.

Impact on the ability to manage mechanisms

Heptral can provoke dizziness, so on the background of therapy with the drug, it is recommended to abandon any activity related to the need for high speed of reactions and concentration of attention.

Overdose

Heptral overdose cases were not recorded during the entire period of observation clinical application drug.

Interaction with other drugs

A confirmed and reliably established interaction of heptrane with other drugs was not detected. However, there are data from individual observations on the emergence of overpowering serotonin on the background of receiving heptrala. Therefore, it is recommended to use heptral with tricyclic antidepressants with caution, selective inhibitors Reverse seizure of serotonin and preparations containing in tryptophan.

Side Effects of Heptra

Tablets and heptrala injections can provoke the same adverse reactions, among which are most common nausea, abdominal pain and diarrhea. In addition to them, heptral in any dosage form can provoke the following side effects from various organs and systems:
1. The immune system:

• Highland swelling;
• Allergic reactions (swelling of quinque, skin reactions, shortness of breath, bronchospasm, pain in the back, tachycardia, bradycardia, etc.).

2. Skin covering:

• Irritation at the injection site.

3. Nervous system:

• Dizziness;
• Headache;
• Paresthesia (feeling of the running of goosebumps, etc.);
• Feeling of concern and anxiety;
• Confusion of consciousness;
• Fever.

8. Infection urinary tract.

Contraindications for use

The lyophilisate and pills of heptrala are contraindicated to use if a person has the following diseases or states:

• Genetic disorders that determine the impaired methionine cycle, homocideurium or hypergomocysthenemia;
• Vibrant vitamin metabolism in 12;
• Increased individual sensitivity to the components of the drug;
• Age under 18 years old;
• II II trimesters of pregnancy (until the 27th week of gestation inclusive);
• Breastfeeding period.

Heptral - analogs

The pharmaceutical market has synonyms and heptrane analogs. Synonyms are drugs containing the same active substance as heptral. Analogues consider other drugs from the hepatoprotectors group containing other actants, but possessing the most similar spectrum of therapeutic effects.

Synonyms heptra

• Heptor Tablets and lyophilisate;
• Heptor n tablets.

Analogues of Heptra The following drugs are:

• Brency Forte Capsules;
• Vg-5 tablets;
• Hep-Merz Granules and concentrate for the preparation of the injection solution;
• Hepatosan capsules;
• Hepor Capsules;
• Heptong solution for injections;
• Histidine solution for injections;
• Glutarteine \u200b\u200bconcentrate and solution for injection;
• Glutamic acid pills and granules for the preparation of the solution for intake;
• Dipana pills;
• Potassium orotat tablets and pellets for cooking syrup;
• Carnituity solution and tablets;
• CARNITTIN Capsules, solution and concentrate;
• Carsil Dragee;
• Carsil Forte Capsules;
• COMIRELT MN Solution for subcutaneous administration;
• Essliver Forte Capsules.

What is better heptra?

In medical practice there is no concept of "best" in relation to various drugs. Practitioners doctors prefer to use the term "optimal", under which the drug is understood, which is suitable for a particular person in the current situation in the best possible way. That is, for different people, depending on the individual characteristics at the same pathology, various drugs will be optimal. Moreover, for the same person suffering from chronic disease, various drugs can be optimal at different stages of life. It is a drug that optimally suitable concrete person in this situation will be the best for him.

Thus, it is impossible to distinguish any of the best drug, which would be invariably and equally effective in various diseases among different people. And in each situation, one or another drug may turn out to be the best. Therefore, it is not possible to distinguish a number of drugs that would be "better" heptra.

Choosing between heptales and other hepatoprotectors, you should navigate only on your own sensations. If someone is subjectively suited and transferred heptral, then it needs to be considered "the best" drug. If the same person at another point is more suitable, for example, Essentialya, then this particular drug will be "best", etc.

If we compare heptral with synonyms, also containing adhemationine as an active substance, then all the presented drugs are worse than heptrala in the pharmaceutical market, because more often cause side effects and are heavier tolere. From this position there is nothing better than heptrala.

Hepatoprotekotors are prescribed to improve the functioning of the liver. Their group includes heptrals, the medicine other than hepatoprotective properties is endowed with other therapeutic effects.

Composition and properties of medication

The main active component is adhemethionine. Produced in two dosage forms - in tablets and in ampoules with lyophilisate for the preparation of an injection solution.

The main property of heptra is hepatoprotective. That is, the drug improves the regeneration of hepatocytes, strengthens the protection of body tissues and has a cleansing effect on the liver. In addition, the medication is endowed with other therapeutic effects:

Due to the integrated effect on the organism, heptral is used to treat the pathologies of the liver flowing with concomitant diseases.

Assign the drug should a doctor after evaluating the results of the survey conducted, independent use does not always lead to the desired result.

Heptral is primarily a hepatoprotector, so basically medicine is used to improve the functioning of the liver.

Comparative characteristics of hepatoprotectors

Hepatoprotectors are a large group of pharmaceuticals, each of which has its own testimony and contraindications to use. Choosing medicines, their composition should be taken into account, the mechanism of action, the therapeutic effect and the likelihood of developing adverse reactions. It is necessary to take into account the opinion of the doctor, since the specialist of the treatment regimen is prescribed on the basis of the severity of the disease, the age of the patient and the accompanying pathologies.

When choosing one of the drugs to improve the functioning of the liver, it is necessary to take into account their combination with the medications used at the moment of treatment.

Preparations that normalize the work of the body provide the best therapeutic effect while complying with diet and therapy during their use.

A number of hepatoprotectors have a cumulative property, that is, they begin to act only after several days or weeks of reception. Therefore, to achieve necessary effect Preparations should be drunk in full compliance with the instructions.

Instructions for use

The daily dosage of heptrala 800 - 1600 mg, which is 2-4 tablets. Take them in two three times. Tablets are better to drink in the first half, as the medicine has a tonic effect on the body. They should not be chewed and grind, after use, the drug is powered by a small amount of water. The duration of the reception of the tablets is determined by the doctor. On average, the medication should be taken from 2 to 4 weeks.

The lyophilisate in ampoules is intended for intramuscular and intravenous administration. Powder is bred immediately before use. Preference is given to intravenous injections, since after administration to the muscle, the likelihood of local adverse reactions is high.

Daily dosage - 1-2 ampoules, a course of treatment for 2 weeks, in the future, if necessary, go to the tablet form of the drug. Medicine in ampoules are prescribed for treating patients with depression. In this case, injections can be installed for 15-20 days.

Opinion of doctors about the effectiveness of the means

Practicing doctors heptrals consider one of the most powerful hepatoprotectors, the use of which significantly reduces the risk of liver cirrhosis in predisposing violations.

However, a number of specialists believe that it is not appropriate for all pathologies of the body.

The need for medicines with a pronounced therapeutic effect is estimated after laboratory and tool methods Surveys.

If the liver functions are changed slightly, it is better for the restoration of the body to use gently affecting hepatocytes drugs, including certified dietary supplements.

Analogs with similar impact

Analogues of heptrala, endowed with a hepatoprotective effect, quite a lot. The cost of medicines from this group will vary greatly. So, for example, heptral costs about 1,800 rubles per pack, and about 350 rubles. But it must be borne in mind that several packages may be required for the entire course of treatment of a cheap analogue.

Name	Structure	Features	average cost
Hep-Merz.	Ornithine Aspartat	Suitable for eliminating the effects of medicinal and alcohol poisoning	Hepamerts in oral powder costs about 800 rubles
Maksar	Maakia Amur Wood Extract	Contraindicated patients under 18	1100 rubles
Rezalyut	Phospholipids	Effective in the treatment of psoriasis, neurodermit, radiation lesion of the liver	450 rubles

Updated: 07/07/2019 18:42:55

Expert: Evgeny Ginzburg

Heptral and heptor are popular hepatoprotectors, around which disputes are being disputes about efficiency. We disassembled drugs to understand what better.

Features of Heptrala

The enzymatic hepatoprotective agent heptral contains adhemationine. Released in France and Italy by Ebbot Labatoriz. It has two forms of release - capsules and lyophilisate.

Admethionine protects liver cells from adverse effects of exposure, namely toxic substances, heavy metals, slags. The substance leads to normal the secretory function of the gallbladder, stimulates the removal of bile in the intestine.

Heptraly promoted recovery processes In the liver. The medicine has an anti-inflammatory effect, reduces acid toxicity, prevents cirrhosis and fibrosis. At the same time, the tool has an anesthetic effect during osteoarthritis and according to some data positively affects the work of the brain.

The properties of ademethionine:

normalizes exchange processes;

activates the development of liver enzymes;

contributes to the normalization of the energy cell balance;

dissolves cholesterol counters;

enhances immunity at the intracellular level;

normalizes the level of biochemical indicators, including transaminases.

The effect of the drug is preserved for 12 weeks after passing the main course. Neuroprotective action is observed within 2 weeks from the beginning of the course, which is manifested in preventing anxiety and depressive disorder.

Research and efficiency

Heptral acts as an effective medicine in the treatment of inflammatory liver diseases and cholestasis. The effect of application is largely determined by the duration of treatment and the chosen dosage doctor. The tolerability of the drug is good with long use and a short course.

Research that was conducted with the participation of 60 patients with chronic pathologies The liver showed a high effect of the use of hepta in patients with alcoholic lesions. The most part had a positive dynamics of the organ size. Almost all such treatment was accompanied by the subsequent improvement of the condition with the disappearance of clinical manifestations.

Source: O.N. "Ademethionine in the treatment of chronic liver diseases with cholestasy", 2008.

Contraindications

The drug heptral is contraindicated in minors. It is used with caution during pregnancy and lactation. Contraindications will be some genetic anomalies, allergies to components, bipolar disorder.

Side effects

Unwanted symptoms in the treatment are possible from the following systems and organs:

immunity - anaphylactic shock and allergies, swelling of quinque;

GCT - flatulence, bloating, vomiting, dryness of the mucous membrane, esophagitis, gastrointestinal bleeding;

Sss - phlebitis, tides;

other are muscular spasm, fever, flu-like state, arthralgia, asthenic syndrome.

With a long-term course of therapy there is also the likelihood of urinary tract infection. If any unwanted symptoms appear, you need to immediately visit your doctor for correction of the treatment regimen.

Dosage

The solution is used intravenously and intramuscularly. For cooking, powder is divorced in L-lysine. Intensive therapy implies an introduction of 400-800 mg per day for 2-3 weeks.

For supporting treatment, tablets are assigned. In this case, 800-1600 mg per day is shown. The medicine in the first half of the day is bought, which is associated with a minor nervous excitation that heptral provokes. The duration of oral administration is from 14 days to 2 months.

Who fits

Heptral has the following testimony to the appointment:

cholestasis;

cholecystitis;

cholangitis;

toxic, viral, drug, alcohol damage;

fatty dystrophy;

1. abstineent syndrome;

   depressive disorder.

Tool Description Heptor

Heptor - hepatoprotector and antidepressant based on adhemethionine. It has the same effect as heptral, but is produced by the domestic company Veropharm. Release form - tablets and powder.

Heptor provides several actions:

antidepressive;

hepatoprotective;

antioxidant;

antifibrosis;

neuroprotective;

regenerating;

detoxy.

Research and efficiency

The drug heptor favorably affects the recovery of patients with alcohol liver damage. The medicine reduces the severity of pain syndrome, reduces dyspepsia, asthenic syndrome. After a 3-week course of reception, the improvements of blood indicators are noted. Heptor is able to reduce the severity of cholestatic and inflammatory syndromes.

Treatment time to achieve the desired effect should continue from 3 months. After this time, hepatoprotective and metabolic properties of the drug are maximally implemented.

Such conclusions did D.M. Tkachenko E.I. In its article "The clinical capabilities of the drug Heptor in the treatment of patients with liver alcohol disease."

Contraindications

The drug does not apply with increased sensitivity to the component in the composition. The medicine is not appointed under 18 years and is not recommended for use in 1-2 trimesters of pregnancy.

Side effects

Due to the acid pH of the active component, some patients experience unpleasant sensations in the epigastric area. Discomfort short-term and does not cause the course to stop the course.

Dosage

Tablets are accepted inside between meals. For supporting therapy, the dosage is 800-1600 mg. Duration - 2-4 weeks. Intravenous and intramuscular administration is carried out in the hospital when carrying out intensive therapy.

Who fits

Heptor can be assigned with the following violations:

cholestasis;

1. secondary encephalopathy;

   abstineent syndrome;

   depression;

   hepatitis.

Cost and analogs

What drug is better

Heptra and heptor - interchangeable medicines. Doctors are often prescribed first heptor due to its lower cost. Heptral applies in the case when domestic drug Causes adverse reactions. Both drugs are well tolerated and there are no significant differences.

with long-term treatment, it is necessary to regularly donate blood test to the level of creatinine and urea;

adhemationine with caution is combined with antidepressants and preparations based on tryptophan;

when operating transport and mechanisms, it should be borne in mind that drugs on adhematione can cause dizziness.

In the treatment of liver pathologies, it is necessary to be guided by the appointment of a doctor. Before taking funds, a specialist consultation is needed.

Hi friends! In this article we will try to figure out that heptor or hepta.

Earlier in the previous 2 articles, we have already discussed each of them separately: as well.

Here we will conduct a kind of comparative analysis of both drugs, in order to reveal which one is better based on patient reviews.

Some experts argue that in the Russian heptor, the chemical formula of the original drug heptral is not exactly reproduced, which adversely affected its clinical efficacy.

Here we will try to determine how true this statement is and what medication is really better.

What is better heptor or heptral

In modern clinical conditions, the need for an effective hepatoprotector is very common - a preparation of rapidly regenerating liver parenchyma cells (hepatocytes).

And since the original Italian drug Heptral is quite expensive (presumably it, all the same, better), the Russian pharmacological concern Veropharm has developed a cheaper generic (substitute). Togo and other drug is identical contraindications To which include:

• Hypersensitivity to additional components;
• The second and third trimesters of pregnancy;
• Age up to eighteen years.

Although these medicines and absolutely identical pharmacological effect and similar clinical effect, but the Russian medication produced in Belgorod is characterized by a large number of side effects.

Probably the reason for this is very different than the Italians, auxiliary substances. The active substance of both is hepatoprotective amino acid adhemationine, produced by naturally human organism.

It has a positive impact on metabolic processes in liver and brain cells. Therefore, the reception of each of them not only increases the concentration of adhemationine in tissues, but also stimulates the production of this amino acid.

To side effects As heptor and his "brother" belong:

1. Possible pain in the area of \u200b\u200bgastrointestinal tract;
2. Dyspeptic disorders;
3. Heartburn;
4. Allergic manifestations.

As you can see, in these indicators they are equal, therefore, we better try, listening to the statements of patients, to evaluate each of them.

Heptor reviews

The network gathered a provisional number of opinions, which gives abundant food for analysis.

Statement №1:

So one user in his recall claims that he has experience in reception and the other drug. To say that it can not be better, since he did not notice the differences between them in the therapeutic effect. However, the domestic heptor is several times cheaper that with the duration of courses is of great importance.

But, about the preparation heptor reviews for the most part bore in the tonality.

Statement number 2:

For example, another user claims that after receiving the heptor, heptacled headaches all night.

Such different estimates may indicate the need individual choice Hepatoprotector on the basis clinical Indications and anamnesis. And now we know what patients are written about Heptra.

Heptral Reviews

Analyzing that people write that you can say that diametrically opposite statements come across - one better than the other. Therefore, if you start learning about heptral reviews - you can come to some confusion.

The network is a review of the user's review of the following content:

"He took heptral during the week. For the fourth day, multiple side effects began to be manifestable: nausea, general weakness, chills, colic in the liver area. Not such a harmless medicine. "

This opinion is dissenisled with a review of another user:

"To date, this is the best hepatoprotector. After two courses, no adverse events were observed, all the indicators of hepatic samples improved. "

And from all this it is possible to make a logical conclusion that the perfect hepatoprotector has not yet been invented. If we talk about what is better heptor or heptralBoth of them have a similar clinical action and the whole beams of similar side effects.

annotation

Heptral (MNN in Latin "Heptral") is a medicine that is used as a hepatoprotector for the liver and is antidepressive. Combines regenerating, antioxidant and dense properties. The drug has a way to clean the liver well. (Information provided Wikipedia and Vidal Directory)

What helps, indications for use

Prescribe the drug when it is necessary to treat the liver, gallbladder, ducts. It can be recommended and used as a preventive preparation.

As a rule, prescribed during hepatitis, with psoriasis, during depression, with fatty hepatosis, with cirrhosis, with pancreatitis. You can also apply after chemotherapy.

Composition how much costs

Release form: ampoules for injection, tablets.

Structure: The ademitonine active substance is 400 mg. As auxiliary: Calloid silicon dioxide, MCC, magnesium stereate, sodium carboxymethyl starch.

Pills covered White shell.

Manufacturer: Country Italy.

average cost In Moscow, in St. Petersburg 1500 rubles for 20 tablets.

Analogs

Analogs that are much cheaper than a lot. But the difference in them is essential. There are many non-contained generics. It is a walkpap, Carsil, Heptor, Essentialy Forte, Ursosan, Phosphoglie, Essliver, Hep-Merz, adhemethionine, Remaksol.

The opinion of the doctors, what exactly of them is better, diverged. But, before replacing the drug, consult your doctor who will write a recipe and prescribe a dosage of medication.

What is better than Esssential Forte or Heptral?

These drugs should appoint only a doctor to the patient, as they have a therapeutic effect. Essentialy contains more vitamin complex and it can be taken for a long time, about 2 months, while hepta is a steadily active substance. Doctors for treatment are more often prescribed heptral, but as a dropper. So its action is enhanced.

Heptor or heptral What is better?

Heptor is a Russian hepta substitute, generic. Produced means Belgorod. Their differences are weighty. Heptral is quite expensive, but has fewer side effects than heptor. Cause in additional substances.

Heptral instructions for use

The medicine must be taken inside in the first half of the day, between food. Why receive in the first half of the day? Because it can cause excessive activity of the body, nervous excitement, which is not needed before bedtime. How many days will be a treatment, appoints exclusively by the doctor.

Injection

Daily dose of dry preparation 400-800 mg. For the treatment of liver 2 weeks, from depression - 3 weeks. Preparation of the solution is possible only before the dam.

Ampoules intravenous, drip injections

If you need to put a dropper, then it is additionally bred in physical and slowly, gradually administered to Vienna.

But you can also do not breed and enter insert into Vienna. In more detail, how to drip the medicine, the doctor will tell.

Pills

Tablet drink in the morning. It is possible before meals (lunch), do not chew and wash with plenty of water.

During pregnancy, you can?

Drink the drug during pregnancy, without harm to the child, can be with the III trimester. The rest of the time, as well as in breastfeeding (lactation), only if the benefit of the mother exceeds the risk for the child.

Hepatoprotector, has antidepressant activity. It has choleretic and chopinetic effects. It has detoxification, regenerating, antioxidant, antifibering and neuroprotective properties.

It fills the deficit of adhemationine and stimulates it in the body in the body, primarily in the liver and the brain. Participates in the biological reactions of transmelorination (donator of the methyl group) - the S-adenosyl-L-metyonine molecule (adhemationine), is a donator of the methyl group in the reactions of methylation of phospholipids of cell membranes, proteins, hormones, neuromediators; Participates in translucelfating reactions as a cysteine \u200b\u200bprecursor, taurine, glutathione (provides an oxidation and reduction mechanism of cell detoxification), coenzyme acetylation. Increases glutamine content in liver, cysteine \u200b\u200band taurine in plasma; Reduces the content of methionine in serum, normalizing metabolic reactions in the liver. In addition to decarboxylation, it is involved in aminopropyl processes as a precursor of polyamine - Pretrasin (stimulator of cell regeneration and hepatocyte proliferation), spermine and sperm included in the ribosoma structure.

It has a choleretic effect due to an increase in the mobility and polarization of hepatocyte membranes, due to the stimulation of the synthesis of phosphatidylcholine. This improves the function associated with membranes of hepatocytes of bile acids and contributes to the passage of bile acids in the biliary system. Effective with intra-robber variant of cholestasis (violation of synthesis and bile current). Promotes the detoxification of bile acids, increases the content in hepatocytes of conjugated and sulfated bile acids. Conjugation with Taurin increases the solubility of bile acids and eliminating them from hepatocyte. The process of sulfatization of bile acid contributes to the possibility of their elimination by the kidneys, facilitates passing through the hepatocyte membrane and elimination with bile. In addition, sulfated bile acids protect the liver cell membranes from toxic action inculfated bile acids (in high concentrations of hepatocytes present in intra-brand cholestasis). In patients with diffuse diseases of the liver (cirrhosis, hepatitis) with intrahepatic cholestase syndrome, reduces the severity of the skin and changes in biochemical indicators, incl. Level of direct bilirubin, SHF activity, aminotransferase.

Pharmacokinetics

After one-time intake, in a dose of 400 mg C Max, adhemethionine in the plasma is achieved after 2-6 hours and is 0.7 mg / l. The bioavailability of the drug when taking inside is 5%, at a per / m administration - 95%.

Bonding with serum proteins is slightly.

Penetrates through the BC. Regardless of the path of administration, there is a significant increase in the concentration of adhemationine in spinal fluid. Metabolized in the liver. T 1/2 - 1.5 h. Is excreted in the kidneys.

2. Form release

Tablets, coated with an intestine-soluble shell of yellow, oblong, double-screwed.

Auxiliary substances: Crospovidone (Polyplastone X EL-10) - 19 mg, microcrystalline cellulose - 53 mg, mannitol (mannitis) - 53 mg, magnesium stearate - 15 mg.

The composition of the shell: acrylic - 61.3 mg, oxypropylmethylcellulose - 21 mg, copovidon (PlayDon ES-630) - 9 mg, polyethylene glycol 6000 - 3.7 mg.

10 pieces. - Packaging cell contour (2) - packs cardboard.

3. Dosage

Apply inside, in / m or in / in (very slow).

When ingestion, the daily dose is 800-1600 mg.

With / in or per / m administration daily dose is 400-800 mg.

The duration of treatment is established individually depending on the severity and course of the disease.

In elderly patients, treatment is recommended to begin with the smallest recommended dose, taking into account the decrease in the hepatic, renal or heart function, the presence of related pathological conditions and the use of other drugs.

4. Interaction

There is a report on the development of serotonin syndrome in a patient who used adhemationine and clomipramine.

It should be used to use adhemethioles simultaneously with selective inhibitors of serotonin inverse seizure, tricyclic antidepressants, preparations and vegetable means containing tryptophan.

5. Side effects

From the digestive system: often - nausea, abdominal pain, diarrhea; Rarely - vomiting, dry mouth, esophagitis, dyspepsia, meteorism, gastrointestinal pain, gastrointestinal bleeding, hepatic colic.

From the nervous system: rarely - confusion, insomnia, dizziness, headache, paresthesia.

From side bone-muscular system: Rarely - arthralgia, muscle cramps.

From the side of the urinary system: rarely - urinary tract infections.

From the side of the skin: rarely - hyperhydrosis, itching, skin rash.

Local reactions: rarely - reactions at the injection site; Very rarely - reactions at the injection site, skin necrosis at the injection site.

Allergic reactions: rarely - anaphylactic reactions; Very rarely - the swelling of Quincke, the swelling of the larynx.

Others: rarely - tides, surface phleets, asthenia, chills, flu-like symptoms, weakness, peripheral swelling, hyperthermia.

6. Indications

Intrahranny cholestasis with preciprotic and cirrotic conditions, including: liver fluid dystrophy; chronic hepatitis; Toxic lesions of the liver various etiology, including alcoholic, viral, medicinal (antibiotics, antitumor, anti-tuberculosis and antiviral drugs, tricyclic antidepressants, oral contraceptives); chronic besamen cholecystitis; cholangitis; cirrhosis of the liver; Encephalopathy, incl. associated with hepatic insufficiency (including alcoholic).

In the II and II trimesters of pregnancy, adhemationine apply only in case of extreme necessity, when the expected benefit for the mother exceeds the potential risk to the fetus. The use of adhemationine in high doses in the third trimester of pregnancy did not cause any unwanted effects.

The use of adhemationine during breastfeeding period is possible only if the expected benefit for the mother exceeds the potential risk for the child.

Application in children

Contraindication: children's and teenage age up to 18 years.

special instructions

With caution to use adhemationine in patients with renal failure, with bipolar disorders, simultaneously with selective inhibitors of serotonin reverse seizure, tricyclic antidepressants (such as clomipramine); preparations of vegetable origin and preparations containing tryptophan; In elderly patients.

The insufficiency of vitamin B 12 and folic acid may lead to a decrease in the concentrations of adhemationine, therefore their associated use in ordinary doses is recommended.

Patients with depression need careful observation and constant psychiatric care in the treatment of adhemationine in order to control the effectiveness of treatment.

When applying in patients with cirrhosis, a systematic control of the nitrogen level is necessary in the background of hyperasotemia. During long-term therapy, it is necessary to determine the content of urea and creatinine in serum.

Impact on the ability to driving vehicles and control mechanisms

When using adhemationine, dizziness may be dizz. Patients should not be controlled by vehicles or work with other mechanisms to completely disappear symptoms that may affect the reaction rate under the specified activities.

The drug is produced in the form of tablets that cover the yellow sheath dissolving in the intestine. In the transverse section, two layers are visible. Tablets are packed in a blister of 10 pieces, 1 or 2 such blisters are stacked in a cardboard box. The tablets are also implemented in the cans from the polymer or from dark glass, in which 20, 40 or 50 tablets are packed.

Also, the drug is produced in the form of a lyophilisate from which a solution is prepared. It is introduced intravenously and intramuscularly. The medicine is contained in the bottle, which is packed in a cardboard pack.

pharmachologic effect

Heptor It is a hepatoprotective agent, which, moreover, has antidepressant influence. On the body, this tool has a regenerating, antioxidant, detoxification, antifiberous, neuroprotective impact.

Active component of the means is admethionine . This substance takes part in some biochemical processes in the human body, activates the products of endogenous adhemationine. This substance is in the tissues, as well as in the biological fluids of the body. It is involved in biochemical reactions. Also, adhemationine is the predecessor of polyamines, including Pretradescin, stimulating the recovery of cells and the proliferation of hepatocytes.

Pharmacodynamics and pharmacokinetics

The preparation in the form of tablets covers the shell, which dissolves in the intestine, therefore, the active ingredient is released directly in the duodenum. After oral use, bioavailability equals 5%. The maximum concentration of the drug is observed 2-6 hours after the patient takes it in a dose of 400 mg once.

The active ingredient is slightly associated with plasma proteins. In the cerebrospinal fluid there is a high concentration of the drug. The active substance penetrates through the BC.

Biotransformation The means occurs in the liver. It is excreted from the body by the kidneys, the half-life is 1.5 hours.

Indications for the use of heptor

Indications for the use of the drug are as follows:

• treatment of patients with S. intrahranny cholestazom ;
• , precimirotic states;
• treatment hepatitis various genesis, including toxic, medicinal, and also;
• secondary origin;
• development;

Contraindications

The drug is not prescribed if the patient has the intolerance to a certain component of the drug. Caution is treated with heptor of people who are diagnosed with liver cirrhosis, associated with hyperazotemia. In this case, treatment is carried out only under the condition of constant control of nitrogen content in blood plasma.

Side effects

As a rule, heptor is well tolerated. In some cases, in the process of treatment, there is a sense of discomfort in the field of epigastrium associated with acidic pH of the active substance. As a rule, this side phenomenon disappears independently and does not require cancellation of treatment or additional therapy by other means. Rarely can develop.

Instructions for the use of heptor (method and dosage)

Before taking the drug heptor, instructions for use must be carefully read. The tool is applied orally, the tablets are preferably swallowed by the whole, not chewing and grinding them. You need to remove the tablet from the package immediately before receiving. The instruction on the use of the heptor provides that it is desirable to receive a heptor to obtain the maximum effect during the period between meals.

How much time the treatment should continue, the doctor determines, taking into account the patient's condition. For supporting treatment, adults are prescribed from 2 to 4 tablets daily. They need to be taken in several techniques.

On average, the treatment with the means continues from 2 to 4 weeks. If there is such a need, a re-treatment may be appointed. Tablets and ampoules Heptor should not be used in the evening, as the influence of the body on the body can be observed.

Overdose

There is no information about overdose by the drug Heptor.

Interaction

There is no information about the manifestation of drug interaction.

Terms of sale

In pharmacies, the heptor is implemented according to the recipe.

Storage conditions

It is necessary to save tablets in the original packaging, you should take them from entering direct sunlight. At the same time, the temperature should be from 15 to 25 degrees.

Shelf life

Heptor can be stored for 2 years.

special instructions

Due to the fact that the drug has a tonic effect, the means should not be used before bedtime.

If the course of treatment with this LS is prescribed to people suffering from cirrhosis of the liver against the background of hyperazotemia, it is necessary to ensure clear control of nitrogen content in the blood.

The special shell of the tablets dissolves exclusively in the intestine, so the release of the active substance occurs after the tablet falls into the duodenum.

In people who suffer from bipolar affective disorder, inversion inversion can be induced in the treatment of adhemationine.

In the treatment of heptor, there is no influence on the ability of a person to driving transport and working with accurate mechanisms.

Synonyms

Analogs of heptra

Coincidences on the ATX 4 level code:

Analogs of the drug Heptor - these are medicinal products and Adenosylmethionine Suppose of a similar effect on the patient's body.

What is better: heptor or heptral?

And heptor, and heptral based on a similar active ingredient - adhemethionine. Therefore, their effect on metabolism in the cells of the liver and the human brain is practically no different. Heptral is realized in the form of tablets, as well as injections for administration intravenously and intramuscularly. The main differences are the manufacturer and the cost of these drugs. Heptor - drug of domestic production. Heptral produced in Italy, respectively its cost above.

Children

Not applied to the therapy of children and adolescents until 18 years.

During pregnancy and lactation

In the first two trimesters it is impossible to use heptor. In the third trimester, the tool can be appointed only if such a decision takes the attending physician. It is important to regularly and very clearly monitor the state of health of the mother and fetus. In the months of feeding, a woman can practice heptor treatment only after the doctor's appointment, which decides on the possibility of continuing breastfeeding.

In modern conditions, it is very often necessary to restore the patient's liver condition, it is necessary to assign an effective and affordable hepatoprotector - substances that promotes the regeneration of hepatocytes (liver parenchyma cells). Despite the fact that some experts believe that the perfect hepatoprotector is the same unattainable ideal, as well as the philosopher's stone, there are real movements in scientific developments and now heptral is indeed the most demanded drug of this kind. But when prescribing this medicinal product, most patients have a question - is it possible to find an analogue of heptrala on the pharmaceutical market, comparable to it by the mechanism of action and clinical effects and more affordable.

Heptral - clinical effects and comparison with other hepatoprotectors

Active substance Heptrala is an adhemationine - amino acid of the human body, which has a direct impact on the metabolism processes in the cells of the liver and brain, and the introduction of this drug not only introduces an additional amount of amino acid into the body, but also stimulates it by the production of liver cells, due to which it turns out to be disinfection, regenerating, Antioxidant, neuroprotective and antifibrosted action. In the pharmacy network, the drug is in two dosage forms - heptral injections for intramuscular or intravenous administration and heptral tablet pills.

An analogue of the hepta of domestic production is heptor, but this drug in the pharmaceutical market is represented only in the form of tablets for intake. The cost of it is much lower than the cost of the original drug, but this medicine It can not even be attributed to generic heptrala - in it the chemical formula of the original substance is not fully reproduced. The composition of heptrala contains a more active left-handing isomer of adhemethionine, while the heptor includes a leaving isomer, whose activity is somewhat less. In a sense, the methionine itself can be viewed as an analogue of heptrala, but the reception of this medicinal substance for patients with impaired liver functions is practically practically useless - effective metabolism of methionine during hepatic insufficiency is impossible, and this drug often use only novice bodybuilders. In the treatment of patients with damage to liver cells of any origin, if possible, it is not necessary to use an analogue of heptrala, but an original preparation.

In any case, especially when severe condition The patient treatment with this drug should be started with intramuscularly or intravenously - the solution of the drug very quickly decomposes into the light, therefore it is prepared by mixing two components (dry powder and a special solvent) immediately before use. Simultaneously with the parenteral administration of this medicinal substance, it is necessary to start receiving adenometonine inside - if possible, use the original drug or an analogue of heptrala for which there is no form for injection. The patient himself can choose - what a medicine it will use for treatment, but the doctors' duty and provision explain that the difference in the clinical effects of heptra and heptor is noticeable, especially in the treatment of severe lesions