This page contains a list of all the analogues of Bususorelin-Long in composition and indication. A list of cheap analogues, and also be able to compare prices in pharmacies.

• Most cheap analog Buserelin-Long:
• The most popular analogue Bususorelin-Long:
• ATX Classification: Bususelin
• Existing substances / Composition: Bususelin.

Cheap analogs of Bususelin-Long

#	Name	Price in Russia	Price in Ukraine
1	triptohelin	1919 rubles	134 UAH
2	triptohelin Analogue according to the indication and method of application	2617 rubles	893 UAH
3	gozerellin Analogue according to the indication and method of application	3200 rubles	750 UAH
4	bususelina acetat Analogue in composition and indication	3285 rubles	1850 UAH
5	triptorelin Acetat Analogue according to the indication and method of application	5420 rubles	--

When calculating the cost cheap analogues Bususorelin-Long Considered the minimum price, which was found in the price list provided by pharmacies

Popular Analogues Bususorelin-Long

The list of drug analogues Based on the statistics of the most requested drugs

All analogues Bususorelin-Long

The above list of the analogues of the drugs in which are indicated replays Buserelin-Longis the most appropriate because they have the same composition of the active ingredients and coincide the indication to use

Analogs in the indication and method of application

Name	Price in Russia	Price in Ukraine
Leiprorelin	--	--
Leiprorelin	--	--
	16753 rubles	2437 UAH
Leiprorelin	16753 rubles	2437 UAH
Leiprorelin	--	--
Leiprorelin	7875 rubles	1926 UAH
Gozerellin	3200 rubles	750 UAH
Triptohelin	2617 rubles	893 UAH
Triptohelin	8076 rub	1915 UAH
Triptohelin	1919 rubles	134 UAH
triptorelin Acetat	5420 rubles	--

To compile a list of cheap analogues of expensive drugs, we use prices that we provide more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our site is always relevant as of the current day. If you have not found an analog you are interested in, please use the search above and select the medicine youest interest from the list. On the page of each of them you will find all the possible options for the analogues of the search drug, as well as the prices and addresses of pharmacies in which it is in stock.

How to find a cheap analogue of dear medicine?

To find inexpensive analog Medicine, generic or synonym, forward, we recommend paying attention to the composition, namely the same active substances and indications for use. The same drug actors will indicate that the drug is a synonym for a drug, a pharmaceutically equivalent or pharmaceutical alternative. However, do not forget about the inactive components of similar drugs that can affect safety and efficiency. Do not forget about the instruction of doctors, self-medication can harm your health, so before the drafting of any medical drug always consult your doctor.

Bususelin-Long Price

On the sites below you can find prices for Bususorelin-Long and learn about the presence in the pharmacy nearby

Buserelin-Long instruction

Instruction
for the use of drug
Buserelin-Long

Structure
The lyophilisate for the preparation of a suspension for intramuscular administration of a prolonged action containing 3.75 mg of buxeline.

pharmachologic effect
Pharmacotherapeutic Group:
antitumor agent, gonadotropinization of hormone (GNV) analogue.

Bususelin-Long, testimony for use
Hormone-dependent cancer prostatic gland;
Mammary cancer;
Endometriosis (pre- and postoperative periods);
Myoma uterus;
Hyperplastic processes endometrial;
For infertility treatment (when conducting an extracorporeal fertilization program (ECO)).

Contraindications
Pregnancy;
Lactation period;
Increased sensitivity to the components of the drug

Method of application and dose
In the hormone-dependent cancer of the prostate gland Buserelin-Long is introduced in a dose of 3.75 mg (1 injection) intramuscularly (in / m) every 4 weeks. In the treatment of endometriosis, endometrial hyperplastic processes The drug is administered at a dose of 3.75 mg in / m once every 4 weeks. Treatment should be started in the first five days menstrual cycle. Duration of treatment - 4 - 6 months. In the treatment of Mioma, Bususorelin-Long is introduced in a dose of 3.75 mg per / m once every 4 weeks. Treatment should be started in the first five days of the menstrual cycle. The duration of treatment - before the operation of 3 months, in other cases - 6 months; 2 In the treatment of infertility by the method of extracorporeal fertilization (ECO), bususneline is administered at a dose of 3.75 mg (1 injection) in a one-time at the beginning of folliculin (on the 2nd day of the menstrual cycle) or in the middle of the lutein phase (21 - 24 days ) Menstrual cycle preceding stimulation. After the blockade of the pituitary function, confirmed by a decrease in the concentration of estrogen in serum in no less than 50% of the initial level (usually determined after 12-15 days after the injectment of Bususorelin-Long), in the absence of the ovary cyst (according to the ultrasound), the thickness of the endometry is not More than 5 mm, it begins stimulation of supervolution by gonadotropic hormones under ultrasound monitoring and controlling level of estradiol in serum.

Side effects
Allergic reactions: urticaria, hyperemia of the skin, rarely - angioedema swelling.
From the CNS: Frequent mood change, sleep disorders, depression, headache.
From side bone-muscular system: for long use - Demineralization of bones, which is the risk of osteoporosis.
In women - headache, depression, sweating and change of libido, dryness of the mucous membrane of the vagina, pain at the bottom of the abdomen, rarely - menstrual-like bleeding (during the first weeks of treatment).
In men, in the treatment of prostate cancer - during the first 2 - 3 weeks after the first injection, Bususorelin may cause aggravation and progression of the underlying disease (due to the incentive of the synthesis of gonadotropins and, respectively, testosterone), gynecomastia, are "tides", enhanced sweating and Reducing potency (rarely requires the abolition of therapy), the transient increase in the concentration of androgens in the blood, the retention of urination, "renal edema" - swelling of the face, eyelids, legs; Muscular weakness B. lower limbs. At the beginning of the treatment of patients with prostate cancer, a temporary increase in bone pain may occur; In this case, symptomatic therapy should be carried out. There were certain cases of the development of obstruction of the ureters and the compression of the spinal cord.
Others: In isolated cases (causal communication is not clearly established) - thromboembolism pulmonary artery, Dyspeptic disorders.

special instructions
In women, the patient with any form of depression during the treatment period should be under the careful observation of the doctor. The induction of ovulation should be carried out under strict medical supervision. IN initial stage Treatment with the drug is possible the development of the cyst of the ovary. 5 Before the start of treatment, it is recommended to exclude pregnancy and stop taking hormonal contraceptives, but during the first two months of the drug uses other (non-nonal) methods of contraception. After the cessation of treatment, the ovarian function is restored. The first menstruation is resumed after 3 months. In men in order to effectively prevent possible side effects in the first phase of the drug, the use of antiandrogen is necessary for two weeks before the first injection of Bususorelin-Long and for two weeks after the first injection.

Impact on the ability to drive a car and other mechanisms
Care should be taken when prescribing the drug to patients engaged in potentially hazardous species Activities requiring increased attention and speed of mental and motor reactions.

Medicinal interaction
The simultaneous use of the Buserelin-Long preparation with drugs containing sex hormones (for example, in ovulation induction mode), can contribute to the occurrence of the ovarian hyperstimulation syndrome. With the simultaneous use of Buserelin-Long can reduce the effectiveness of hypoglycemic agents.

Overdose
Currently, overdose cases have not been reported.

Storage conditions
In a dry, light-protected place at a temperature not higher than 25 ° C.
Keep out of the reach of children.

All information is provided for informational purposes and is not a reason to independently appoint or replace medication.

The neoplasms of malignant nature are currently occupied by one of the leading places in the level of mortality among the population almost all over the world. The longer the person puts his visit to the doctor, the harder and the path to recovery will be longer. It is in this direction of medicine that there will be more faithful words that the missed time of equivalent life will be.

In Arsenale modern pharmacology Currently there is a mass of medicines designed to fight malignant tumors affecting the most different organs human organism. For the treatment of hormone-dependent malignant neoplasms today, drugs are widely used - the analogues of the hypothalamus hormones (the brain department responsible for the operation of the neuroendocrine system). One of these drugs is Buserelin-Long.

Composition and form of release

Buserelin acetate is used as the main active component of the drug. From the number of auxiliary to the medicine, the copolymers of dairy and glycolic acids are included, polysorbat-80, sodium carmellosis, D-mannitol.

Today, the pharmacy chain of the Russian Federation offers its consumers this antitumor drug in two form of release. One is a nasal spray (for administration through the nose), the second - powdered composition for the preparation of a solution, which is then administered intramuscularly. Actually, the second form (solution) and is called Buserelin-Long. Instructions for use contains detailed information on the principle of pharmacological impact on the human body.

Usually in the contour cellular package embedded in the cardboard box, there is a bottle with a drug, an ampoule with a solvent, a disposable syringe (volume - 5 ml), 2 sterile needles (for solvent and for injection), a scarifier or a knife for opening an ampoule and 2 alcohol Napkins.

Pharmacodynamics

At the initial stage of the use of this drug, the process of enhanced release of gonadotropins is observed (hormones, the main function of which is the regulation of the function of the germ). During this period, in the composition of patients, the number of genital hormones may be observed in patients with briefly.

After 12-14 days, the effect of the drug causes a blocking of the gonadotropic function of the pituitary gland, which is characterized by the cessation of the secretion of hormones, stimulating the ripening of follicles and the production of lutein. The result is to inhibit the synthesis of sex hormones in the ovaries, and, as a result, the level of estradiol (main female hormone) to indicators characteristic of the post-lock period falls in the blood plasma. A condition of a "drug pseudomenopausova" is developing developing.

If this drug for sufficiently long time is used for therapy for therapy of the prostate gland, the result can be a significant decrease in the blood plasma concentration of testosterone (main male hormone). In a medical environment, this condition is called "Pharmacological castration".

Accessories based on Buserelin during the period preceding surgical intervention about endometriosis will help reduce the size of the foci of pathology, reduce their blood supply, attenuation inflammatory processes. In the postoperative period, the influence of the medication will reduce the formation of adhesions and reduce the frequency of recurrences.

Patients need to know that the influence of the drug is reversible. After canceling the medication, the level of genital male and female hormones in the composition of blood will gradually come to normal.

Who shows the application?

Buserelin-Long "instructions to the medicine recommends taking a reproductive system of human system, caused by absolute or relative hyper estogenic pathological processes. Sufficient grounds for the use of this drug can be considered in women such diseases as the mioma of the uterus, endometriosis, hyperplastic changes endometrial.

In addition, the medication is prescribed with malignant prostate neoplasms (hormone-dependent form, 3 and 4 stages), during breast cancer (if the menstrual cycle is saved, and progesterone and estradiol receptors are available).

Also that's medication It is widely used in the procedures of extracorporeal fertilization (ECO). The main function of the drug in this case is the suppression of the effect of its own hormonal system of a woman. Thus, an artificial controlled hormonal system "forms", allowing implanting a woman already fertilized egg. In the treatment of infertility, buxerlin-containing medicines stimulate the ovulation process.

Contraindications for reception "Bususorelin-Long"

It goes without saying that taking "Bususelin-Long" can not be patients suffering from hypersensitivity to the main or auxiliary components of the drug. Also unacceptably take this drug pregnant women and nursing mothers.

Careful and attentive to their well-being should be people who have a history of obstruction entries urinary tract. Patients should also behave, in whom a malignant prostate gland tumor metastassed into the spine. At the initial stage of treatment, such patients increase the likelihood of developing the exacerbation of the underlying disease.

Patients with diagnoses arterial hypertensionDepression, diabetes must also be under the close attention of the attending doctor at least at the initial stage of receiving a drug medication.

Possible side manifestations

At "Bususelin", as any complex drugs released by a doctor's prescription, are possible negative reactions from different systems and human organs.

The central nervous system can respond to medication by deviations in the processes of sleep and wakefulness, headaches and dizziness, reduction of ability to memorize information and concentration, fatigue and neuropsychic instability. It is possible to develop depression or deterioration of health care if available.

Probable deviations from the senses can be worsening hearing and vision (sensation of blur), noise in the ears. Sometimes patients talk about the feeling of reinforcement of pressure on the eyes.

The appearance of deviations of endocrine nature. Most often you can hear about the "tides" of blood to the face and top chest, to strengthen the sweating, to reduce sexual attraction, the sensations of dryness of the vagina in women, pain sensations At the bottom of the abdomen, the mineral depletion of bones. Not often, it is possible to read about the preparation "Bususelin-Long" reviews of patients (women), which strenching that during the first weeks of the drug, bleeding was observed similar to menstrual secretions.

Probable deviations from the cardiovascular system can be called tachycardia and increasing indicators arterial pressure In patients with a diagnosis of hypertension. The response of the gastrointestinal tract to the drug can be nausea, vomiting, diarrhea, constipation, noticeable fluctuations in one or another side of the body weight, disorders of appetite.

Possible allergic reactions For new preparations that have in their composition Buserelin as the main component (urticaria, itching, hyperemia of the skin). Not often, but we can talk about the development of bronchospasms, shocks (anaphylactic, anaphylactoid), on edema of angioederic origin.

There is a possibility of changing certain physiological indicators measured in laboratory conditions: hyperglycemia, a decrease in the susceptibility to glucose, thrombocytopenia, leukopenia, an increase in the activity of serum transaminases, deviations from the norm in the lipid spectrum.

Sometimes you can hear from patients about the appearance of edema zones in the field of ankles and stop, about nasal bleeding, about activating hair growth on the body and head.

In men's patients with therapy over the oncology of the prostate gland honey. Baseline-based preparations for 2-3 weeks after the first injection may provoke a relapse of the underlying disease, its progression. There is a risk of gynecomastia, an increase in sweating, reducing potency, urination delays. If bone pain occurs in the initial period of treatment, the instruction recommends that symptomatic therapy.

Application: Dosing Mode and Treatment Scheme

Medical preparations like "Bususorelin" must be appointed to receive only the attending physician. With therapy of hormone-dependent oncological diseases of the dairy or prostate gland, the medication is prescribed to the use of intramuscularly in a dosage of 3.75 mg (1 injection). Injections are made with periodicity of 4 weeks. The course of therapy takes a long period of time and must undergo under the control of the attending doctor.

If therapy is carried out over endometriosis, endometrial hyperplastic changes, the diagram of the therapeutic course is the same as during cancer problems (1 injection with periodicity of 4 weeks). To start treatment with the use of the Buserelin-Long preparation, the instruction regulates within 5 days from the beginning of the menstrual cycle. The course of therapy, as a rule, continues from 4 months to six months.

Treatment diagram and dosing mode with uterine Moma - 1 injection with a periodicity of 4 weeks. The beginning of the therapeutic course should be coincided by the first 5 days of the menstrual cycle. The duration of therapy before surgery is at least 3 months. Conservative treatment is usually for about six months.

A somewhat differently looks like a diagram of using a medical preparation in the treatment of infertility using the ECO technique. The first injection "Bususelin-Long" is made either on the second day of the menstrual cycle (the beginning of the folliculin phase), or in the period from the 21st to the 24th day (middle of the lutein phase). After 12-15 days after injection, the number of estrogens contained in the blood serum will fall up to half of the original (blocking of the pituitary function). Further, if the patient does not have a cyst on the ovaries (ultrasound studies), and the thickness of the endometrial layer does not exceed 5 mm, it can be stimulated to stimulate supervision using gonadotropic hormones. These activities are carried out under ultrasound monitoring with the obligatory control of the level of estradiol. The dose of Buserelin-Long can be adjusted in one direction or another.

Before starting a course of therapy with the use of the Buserelin-Long medication, it will not be superfluous to familiarize themselves with some special recommendations that are contained in the instructions for the use of the drug.

Patients-women suffering from any form of depression, in the process of treatment with the drug, it is necessary to be under the close attention of the attending physician. Also strict medical control Requires the procedure for the induction of ovulation. Women should be borne in mind that in the initial period of drug use is the likelihood of the development of the ovary cyst.

Patients Before starting therapy with the use of Buuslelin, should refuse to receive hormonal contraceptive drugs, but for 2 months from the beginning of the course, use non-coroned methods of preventing the occurrence of pregnancy.

• Important! Women before proceeding with medicine, it is recommended to exclude the fact of the occurrence of pregnancy.

At the end of the course of therapy, the functioning of the ovaries will be restored. The first menstruation usually comes 3 months after the completion of treatment.

As for men's patients, in order to avoid the development of negative manifestations at the beginning of the therapy "Bususorelin", it was recommended for at least 2 weeks before the first injection to start taking anti-sandrogen and take them through the crescent after injection.

In addition, if you explore the antitumor preparation "Bususoreling-Long" reviews of health workers or at least carefully read the instructions, it will be possible to find out what patients who by the nature of their own labor activity drive vehicles or are related to the work, the execution of which requires high concentration The attention and speed of psychomotor reactions should be particularly careful when taking medication.

Interaction with other substances and drugs

Within the framework of our article, there remained to consider a few more points relating to the Medicine "Bususelin-Long". The price of the drug, its interaction with other medicines, analogues and feedback from patients - any of these issues are interested in people going to acquire a mentioned medicine. Below will dwell in more detail on each of them.

As any modern medicine, developed with the use of high technologies, Buserelin-Long obeys certain principles, interacting with other drug substances. For example, simultaneous use in the treatment of drugs under consideration by us and drugs, in its composition having sex hormones, during the induction of ovulation, it may cause the state of the state of the state, called the physicians of the ovarian hyperstimulation syndrome.

And the parallel reception of "Bususelin-Long" and drugs of hypoglycemic exposure reduces the effectiveness of the latter.

Price range. Analogs

How much is Buserelin-Long? The price of the drug can make thinking. In the pharmacy chain of Moscow, consumers can purchase this drug for the amount in the range from 3500 to 5,500 thousand rubles. It should be thought that in remote regions of Russia, the drug is even more expensive. However, the effectiveness of the medication fully justifies its fairly high cost.

The spray "Bususelin" is cheaper than the drug in the bottles (Buserelin-Depot - from 3900 to 7,000 rubles), and costs about 800-900 rubles.

As for similar antitumor agents, the Medication "Bususelin-Long" Analogues (structural) active substance - This Buserelin-FSintez medicines (spray), Buusreelin-Depot (lyophilisate for the manufacture of suspension, administration - intramuscularly), "Bususelin acetate" (bottle 0.2%), "Superfact" and "Superfect-Depot".

Opinion of patients about the Medicine "Bususelin-Long"

Like any modern drug, Buserelin-Long Patient reviews has both positive and negative orientation. Those who have positive treated experience drugscontaining Buserelin, talk about good results. A certain percentage of women assures that there are light rings, some have small allocations. After the end of therapy for 1-2 months, the menstrual cycle is restored. In men's patients, after discontinuation of the treatment of "bususlin", sexual attraction is fully restored, and potency.

Another part of the patients remained unhappy with treatment, as, according to their comments, the drug provoked the development of a whole list of side effects. Someone speaks of poor skin condition, about strong headaches, dizziness and constant nausea. In such cases, there may be several reasons. It is impossible to discount the presence of the individual intolerance of Bususorelin. Here the output is only one - change the drug (naturally, only by instructing the attending physician). Negative consequences can be non-compliance with the specialist scheme for receiving medication and changing the dosage of the received drug.

In any case, whatever good or bad experiences of patients describing honey. Preparations (Buserelin-Long "and the like), the decision to appoint a drug should be taken only by the attending doctor who will take into account all the individual characteristics of the disease in each particular patient. Only in this case can be hoped for the achievement of positive results of therapy without risk to cause serious damage to the state of health.

Buserelin is used for comprehensive treatment Hormone-dependent malignant tumors In men and women. This means is produced in the form of a nasal spray or solution for intramuscular injections. At the pharmacy, the medicine can be called the names: "Bususelin-Depot", "Bususelin-Long" and simply "Bususelin". This synthetic analogue of natural gonadotropin-rilizing hormone particularly helps in the treatment of endometriosis (the main complication of which is infertility).

Combination of the course conservative treatment Buserelin with surgical intervention in endometriosis significantly reduces blood loss during surgery and its duration. In the recovery period, the use of these hormones suppresses the development of the remaining foci of inflammation, improves the processes of restoration and regeneration of tissues.

Pregnancy after Bususelin Depot or Long can come in 2-4 months. In addition to endometriosis, Bususelin is used in the treatment of prostate cancer in men, breasts in women and moma uterus.

Comparison of types of produced drugs

Bususorelin Long and depot - what the difference can be seen in the comparative table. And what kind of form it is better to choose for successful treatmentcan only say the attending physician.

Bususelin.
Active substance:
Treatment method:	Intramuscular injections		Nasal spray
Set:	dark glass bottle; solvent in ampoule; two needles syringe.		dark glass bottle with 17.5 ml with sprayer
Bususelina acetate:
Excipients:	dairy and glycolic acid; sodium carmellosis; mannitol; polysorbat-80.		benzalconium chloride and water for injection
Solvent: 0.8% Mannitol solution	in 1 ml of water for injection	in 2 ml of water for injection
Released:	Requires a doctor's prescription
Storage conditions:	Temperature no more than 25 ° C
Storage Term:	Flower bottle - no more than 2 years Ampoule with solvent - 3 years	Flower bottle - no more than 3 years Solvent ampoule - 5 years	Up to 3 years

Everyone drug Treatment Developed and manufactured according to certain technologies and principles. The substances included in its composition can in combination with other pharmaceutical means to give undesirable results. Preparations containing bususlin can not be used in parallel with drugs that reduce blood sugar levels and with sex hormones (when stimulating ovulation).

In which diseases can be appointed Bususorelin

Treatment by this drug is carried out in pathological diseases of the childbearing system:

• myoma uterus;
• hyperplastic changes in endometrial;
• ovarian tumors;
• mammary cancer;
• prostate cancer.

The preparation of Buserelin has proven well in the treatment of infertility with the help of extracorporeal fertilization. He suppresses the work of the hormonal system of the woman itself and makes it possible to artificially manage the processes of ripening egg, its fertilization and implantation in the uterus. It helps a woman successfully become pregnant.

What happens in the body under the action of Bususorelin

Bususorelin is a synthetic analogue of gonadotropin-rilizing hormone (abbreviated GNVG). It refers to stimulating hormones and effectively spurs the pituitary. The active work of this gland internal secretion turns off the production of follicularity-linguing and luteinizing hormones and fully stops ovulation in women. During treatment in the blood, the estradiol content is very low - at the level of post-glimacterial values, and physical and psychological condition Patients correspond to the period of sexuality (mood jump, tides and severe heartbeat).

Under what circumstances the medicine is contraindicated

The preparation of Buserelin can not be taken independently (without appointing a doctor). The doctor will surely check the number of hormones in the blood, will hold an ultrasound examination internal organs And other necessary tests.

The hormonal preparation containing the substance Busenerin is not prescribed if:

• Woman pregnant. The use of medication when carrying a child can lead to a delay in the development of an embryo or miscarriage. Immediately after childbirth, it is also impossible to undergo a course of treatment if the woman feeds the baby's chest. The drug has the ability to penetrate the milk and affect the baby.
• The woman began the period of Klimaks.
• The patient has a period of depression. Besernelin intake may worsen the psychological state.
• It is diagnosed with diabetes or high blood pressure. Vessels with these diseases become fragile and no longer withstand additional load.
• The patient did not reach puberty (so as not to destroy the formative hormonal background).
• With individual intolerance to the components of the drug.

How does the body react in general for treatment

The brain manages all the processes inside a person, producing certain hormones. Any interventions in this difficult process cause deviations in all organs. That is why Bususorelin is accepted only under the supervision of a doctor: to control and in time to minimize negative manifestations. Patients describe such side effects:

Among women	In men
Depression, insomnia, plasticity	The exacerbation and strengthening of the underlying disease, severe pains in the bones
Headaches	Muscular weakness in the legs
Dry vagina	Delay urination
Reducing sexual attraction	Reduced potency
Bleeding similar to menstrual (in the first weeks of reception); Pains at the bottom of the belly	Gynecomastia (breast increase)
Riding	Swelling legs, faces
Increased sweating
Hyperemia (redness)
Urticaria and other allergic reactions (up to an anaphylactic shock)
Washing out calcium from bones (leads to osteoporosis)
Increased blood pressure and tachycardia (nasal bleeding can begin with weak vessels)
The smell is worse, vision becomes fuzzy and blurred
Nausea and vomiting, diarrhea or constipation
Disruption of appetite (causes noticeable fluctuations in weight)

Nasal spray Bususelin

Endometriosis is most often treated drops. They have more affordable pricethan in the drug for intramuscular administration. The daily rate (900 μg) is divided into three receptions. From one spray, the body receives 150 μg of medication. The reception scheme is this: one injection into each nostril three times a day. The nose must be clean so that the entire medication is on its intended purpose. Rubber is not contraindicated courses. The main thing is to follow the purity and passability of the nasal sinuses. Salt solutions can be used to pre-purify the nose from the accumulated mucus.

The main disadvantage of such a form of administration is precise compliance with time intervals. Between receptions (injections) can take place from 6 to 8 hours. Even a night rest will have to adjust, taking into account the reception schedule of medication. The course lasts 3-6 months and, according to the reviews of patients, requires a large patience and self-discipline.

Application of the drug in ampoules

In the form of injection therapy, Bususorelin passes through a simpler diagram than a spray: every 28 days an intramuscular injection is made. For each diagnosis there is a certain method of receiving the drug:

• If treatment is carried out about endometriosis, uterine misa or endometrial hyperplastic processes, then the first injection is made in the period from 1 to 5 days from the start of menstruation. Subsequent injections are set with an interval of 4 weeks. Course therapy - from 3 to 6 months.
• Men with prostate cancer and women with breast cancer are prescribed injections for a similar scheme.
• In case of treating infertility or in preparation for Eco, the first injection can be done on the second day of the cycle (the follicular phase only begins) or in a segment from 21 to 24 days (the lutein phase in the middle). 2 weeks after the administration of the medication, the amount of estrogen in the blood plasma is shrinking twice, and if the ultrasound examination did not show the problems in the uterus and ovaries in the form of cysts, the doctor prescribes the stimulation of the ovulation process (gonadotropic hormones are used). This complicated procedure is carried out under ultrasound monitoring. In the process of therapy, the level of estradiol is constantly monitored, and the dose of Bususelin, the doctor may change depending on the situation.

How to prepare an injection solution

Pharmacy packaging of the drug for intramuscular administration contains a pair of bottles and syringe with two needles. In one bubble there is a drug, and in the second is a solvent. Needles are needed: one for mixing medication, the other for injection. The solvent is recruited by a syringe and is introduced into the capsule with the main suspension. The mixture must be thoroughly shaken, and give the drug to completely dissolve. Then the needle on the syringe is changing and the injection can be performed.

A medication is prepared immediately before entering into the body strictly according to the instructions. To eliminate accidents when intramuscular injectionshould be injected in a procedural office.

Bususorelin is a means for combating malignant tumors. The drug is applied if the growth of the neoplasm depends on the products of hormones. In the treatment of such tumors, synthetic analogues of the rillation hormones are used. Bususorelin is one of these analogues of natural hormones. Bususorelin Long is a prolonged form of the drug. because of long action It is used 1 time a few weeks.

In contact with

The composition of the drug

Drug substance drug is Bususelina acetat. The medication also includes copolymer compounds of dairy and glycolic acids, sodium carmellosis, polysorbat-80 and D-mannitol. Bususoreling Long is produced as a powder. It is bred in a solvent and introduced intramuscularly. The bottle bottle contains a 3.75 mg of the active substance - Buserelin acetate. In one package Buserelin Long is a powder bottle, a solvent in ampoule, syringe, 2 needles (for solvent and for injection), 2 napkins and a knife for opening an ampoule.

Drug action drug

At the first stage of treatment, the content of gonadotropins and genital hormones increases. This increase in the hormonal level is temporary.

14 days after the injection of Bujelin Long Gonadotropin hypophysome generation is blocked. Women stop the production of pituitary hormones that are responsible for the ripening of follicles in the ovaries. As a result, the level of female genital hormones is sharply reduced. The content of estrogen in young women falls to indicators characteristic of the menopausal period. Such a state of doctors is called drug pseudomenopause.

In men, the drug leads to a sharp drop in the level of androgen (male genital hormones). The parameters of sex hormones fall to the level of the postcase period. Doctors call it pharmacological castration. Patients need to remember that in the treatment of Buserelin Long, the decrease in the level of estrogen and androgens is reversible. After the termination of therapy, the content of genital hormones returns to normal indicators.

What diseases do the drug apply?

Instructions for use Buserelina Long speaks about following testimony for treatment Drug:

• uterus diseases caused by excess estrogen (uterine mioma, endometriosis, endometrial hyperplasia);
• breast tumors (with preserved menstrual function and preserved estrogen and progesterone receptors);
• before and after operations over endometriosis (the drug reduces endometrous foci and adhesion formation after surgery);
• hormone-dependent forms of prostate cancer;
• before carrying out an extracorporeal fertilization (ECO) - the drug suppresses the natural synthesis of estrogen, which makes it possible to create an artificial hormonal status required for the embryo substitution.

Who can not take Bususelin Long?

Bususorelin Long is a potent drug that strongly changing human hormonal status. therefore not every patient shows such a means:

Possible side effects when receiving the drug

When treating such a potent drug side effects are not excluded.

• From Central nervous system Perhaps dizziness, headache, insomnia, reduction of memory and scattered attention, fatigue. Understanding depressive disorders Perhaps the deterioration of the mental state.
• From the side of the senses, it is possible to deteriorate hearing and vision, noise in the ears, a feeling of pressure on the eyes.
• Cardiovascular system can also respond to the drug. It is possible to increase blood pressure, tachycardia.
• Manifestations from digestive organs are expressed in dyspeptic phenomena, impaired appetite.
• In patients prone to allergies, skin rashes and itching are possible. Bronchospasm, anaphylactic shock, edema are very rarely observed.
• Very often found side manifestations From the endocrine organs, since the drug is an analogue of pituitary hormones. Many women complain of blood tides to face, reinforced sweating, a decrease in libido, pain at the bottom of the abdomen, increased fragility of bones, dryness in the vagina. This is due to the ability of Bususelin Long sharply reduce the level of female sex hormones. In men because of reduced level Androgen is observed an increase in the chest glands (gynecomastia), a reduction in potency, rare and difficult urination.
• In patients undergoing treatment with prostate cancer, it is possible to exacerbate the symptoms in the first days of treatment with the drug.
• Everything side effects Strengthen when drinking alcohol during the course of treatment.

When therapy of the Buserelin Long is possible changes in blood analysis: reduction of leukocytes and platelets, increasing the level of glucose, changes in the lipid composition of blood.

Treatment scheme Buserelin Long

This drug belongs to potent toolsTherefore, its use is permissible only by appointment of a doctor.

In the treatment of malignant breast tumors and prostate Make 1 injection (3.75 mg) intramuscularly 1 time in 4 weeks. The course of treatment takes a long time and is carried out under careful medical control.

In the treatment of pathologies of female genital organsassociated with excess estrogen (endometriosis, mioma, endometrial hyperplasia), also make 1 shock every 4 weeks. According to the instructions for the drug, treatment is starting in the first 5 days of the menstrual cycle. The course of treatment continues from 3 to 6 months. Therapy before the operation on the moma of the uterus should last about 3 months.

Before conducting the ECO procedure The first injection of Bujelin Long is made either on the second day of the menstrual cycle, or in the period from the 21st to the 24th day. Two weeks after injection, the estrogen level decreases by 2 times. After that, there are an ultrasound examination in order to eliminate the ovarian cysts. Then with the help of gonadotropic hormones stimulate supervision under monitoring ultrasound.

special instructions

In the instructions for the drug are indicated features of the use of Bususorelin Long.

Bususline interaction with other medicines

The medicine is not recommended to be used together with estrogen. The simultaneous admission of burselin and estrogen can cause the ovarian hyperstimulation and the formation of a cyst. Bususrelin can reduce the effect of the use of hypoglycemic drugs. It is necessary to keep in mind the patient diabetesTaking medicine.

Many patients are interested in the value of Buserelin Long bloc. The price of this medicine in pharmacies can be from 3500 to 5,500 rubles. Analogues of the preparation for the active substance are:

The closest means of the means is Bususorelin Depot. Both drugs are generics of the same medicine.

Latin name:Buserelin Long.
ATH code: L02ae01.
Active substance: Bususelin
Manufacturer:F-Synthesis, Russia
Pharmacy vacation condition: On prescription

Buserelin Long is applied to the number of antitumor drugs, is a synthetic analogue of hormone gonadotropin-rilizing.

Indications for use

The use of LS is shown in order to treat hormonal dysfunctions that are caused by hyperal generation (both absolute and relative):

• Endometriosis (therapeutic therapy before the operation and after it)
• Hyperplastic changes endometrial layer of uterus
• The presence of myomatous nodes.

Buserelins can be assigned to the aim of conducting extracorporeal fertilization (ECO) during the treatment of infertility.

Structure

The lyophilisate contained in ampoules contains Buserelin Long - 3.75 mg. Additional components include substances:

• DL dairy and glycolic acid - 200 mg
• D-Mannitol - 85 mg
• Sodium Carmellosis - 30 mg
• Polysorbate - 2 mg.

To dissolve the lyophilisate, mannitis (0.8% solution) is used in 1 ml of purified water.

Medical properties

Bususorelin Long FS is a highly efficient antitumor LS, similar to the natural GGF. The effect on the Buserelin body is based on the time stimulation of the growth of sex hormones in the blood, it is due to this a competitive connection occurs specific receptors cells located on the surface of the front lobe of the pituitary gland.

If the use of the drug is carried out exclusively in therapeutic dosages, there is a blocking of gonadotropic pituitary activities (usually after (12-14 days). The method of testosterone, LG and FSH decreases on Buserelina, which subsequently contributes to the braking of the synthesis of sex hormones inside the gonad. At the same time Women level estradiol is equal to post-glimacteric indicator, in men - the average value of testosterone is reduced to the level characteristic of the postcase period.

During the continuous use of the Buserelin Long FS drug for 2-3 weeks. The testosterone rate is significantly reduced, thereby reaches the state of orchiectomy (the so-called pharmacological castration is observed).

After the injection in the muscle, the bioavailability of drugs is quite high.

The highest concentration of the preparation of the drug is observed after 2-3 hours after the injection (dose - 3.75 mg), in the future, is maintained at the level that is necessary for braking production of gonadotropins by hypophysome (at least 4 weeks).

Form release

Price from 3400 to 4400 rubles.

Buserelin Long FS in the form of lyophilisate is produced in dark glass bottles with a volume of 10 ml, the solvent (2 ml) is additionally attached in the neutral glass ampools with the instruction. Inside the cell packaging are located:

• bracker Bususorelin Long.
• solvent amppy
• disposable syringe (5 ml)
• scarifier
• 2 napkins impregnated with alcohol.

Bususorelin Long: Instructions for use

The drug Buserelin Long should be administered only intramuscularly. There is no significant difference at what time of day the injection is made.

The preparation of a dosage suspension with bousereline is carried out before administration using the attached solvent.

Prepare a solution and pricking hp should be a health worker.

Treatment with this drug is prescribed depending on the type of disease:

• Oncoprocesses in the prostate (hormone-dependent) - 1 in. in the muscle (3.75 mg) with a temporary interval of 4 weeks.
• Hyperplastic changes of the endometrial layer and endometriosis - therapeutic therapy begins on 5th day of MC in the unified dosage of 3.75 mg, the drug administration is carried out every 4 weeks, the course of therapy is 4-6 months.
• The uterine myoma is a unite introduction into the muscle injection with a dosage of 3.75 mg, the LAN is repeatedly necessary after 4 weeks. Treatment should be started for 5 days. From the date of the beginning of the MC, before operation, therapy is carried out for 3 months, in other cases - 6 months. (In combination with different drugs).
• Reception of infertility - Introduction 1 in. In the muscle for 2 days. MC (the possibility of an injection of 21-24 days is not excluded. MC) before the hyperstimulation procedure. After the estrogen level decreases by 2 times, the reception of gonadotropic hormones is assigned. Therapeutic therapy for infertility of other LS is carried out in the absence of cystic ovaries and with regular control of estradiol and ultrasound.

Application during pregnancy and gv

This group of patients is not appointed.

Contraindications

• Increased susceptibility to Busushelin
• Pregnancy, guv.

Precautions

To prevent development adverse Reactions In men in the first phase of the LS, it is recommended to combine use this drugs with androgen drugs (for 2 weeks before the introduction of Bususelin and after 2 weeks after the injection).

In the signs of the development of depression during antitumor therapy, it is best to provide patient constant medical control.

To achieve good results in infertility treatment (conducting the ECO procedure), it is necessary to control the induction of ovulation against the background of the use of booring.

Usually the drug of the domestic producer is moved well, but under some cases, the growth of ovarian cysts can be diagnosed.

Before holding therapy, it is necessary to exclude the onset of pregnancy and replace the accepted COC to the drug, which is distinguished by another content of hormones (the first 2 months. Medical therapy).

After complete cancellation of the drug Buserelin Long FS, there is a restoration of the ovarian function (after 3 months), no differences in their activities in comparison with the period before treatment is not observed.

It is required to observe special care when driving a car and while working with accurate mechanisms.

It is not recommended to acquire the drug outside the pharmacy network, paying attention to the announcements "sell or sell Buserelin Long at a low price." The difference between drugs acquired in the pharmacy network and "from the hands" may be significantly, because the acquisition of a fake is impossible.

Cross drug interactions

It is worth paying attention to the interaction of bushelin with other drugs, which includes different sex hormones. It is impossible to say that they are not compatible with the medicine Buserelin Long FS, but on the background of complex reception, the ovarian hyperstimulation syndrome can develop.

Drug is able to lower therapeutic effect from the use of hypoglycemic drugs.

If we talk about compatibility with other drugs, there are currently no reliable information.

Compatible with alcohol

Bususorelin and alcohol can not be combined. During treatment, it is necessary to completely abandon the use of alcoholic beverages. There is a negative effect of alcohol on the functioning of the reproductive system. Under the influence of alcohol violated exchange processes, slows down the synthesis of genital hormones.

Side effects

Although the drug is characterized by good medical propertiesAgainst the background of therapy, adverse reactions may arise.

In men:

• The exacerbation of the flow of oncoprocesses in the prostate
• Gynecomastia
• Erection deterioration
• Strong blood tides to the head
• Excessive selection of sweat
• Growing the level of androgens in the blood
• Edema of the limbs as well as faces
• Weakness in muscles
• Humped urinary removal
• The development of ureteral obstruction, rarely - disruption of the spinal cord.

Among women:

• Breakthrough bleeding by type menstruation
• Development of depressive state
• Strong headaches
• Violation of the quality of sleep
• Change emotional attitude
• Dryness inside vagina
• Sensation of "tides"
• Painful sensations in the lower abdomen
• Increased sweating
• Discardial libido.

Common symptoms may also be observed:

• Skin hyperemia
• Handle
• Demineralization of bone tissues
• Rarely - the development of dyspeptic phenomena, the development of thromboembolism of one of the arteries of the lungs.

Storage conditions and shelf life

Store the antitumor agent Buserelin Long FS follows at a temperature not exceeding 25 S. Saving term is 2 years.

Analogs

Farmsintez, Russia

Price from 3624 to 4611 rubles.

Buserelin depot is a great preparation with antitumor properties, the current component is Bususrelin. It is appointed for the treatment of cancer of the genitourinary system in men and women, it is used for infertility therapy. Produced in the form of lyophilisate.

Pros:

• Has good antandrogenic properties
• Used to treat endometriosis
• High efficiency in the treatment of malignant neoplasms of the breast.

Minuses:

• Expensive
• Recommenders are released
• High risk of developing adverse reactions.