In one ml of the drug insulin humulin focused 100 meters of human insulin. Active components of the funds should be considered 30% of soluble insulin and 70% insulin isofane. As an additional components, such elements are used as a humid metacronol, phenol and some others. Special attention deserves readings for use, instructions and some other information.

All about the form of insulin

The injection composition of Humulin NPH Insulin is manufactured as a suspension for subcutaneous implementation. It is produced in 10 ml bottles, as well as in 1.5 and three ml cartridges, which are packed in five pieces. Cartridges are intended for use in Humapen and BD-Pen syringe knobs. It should be borne in mind that:

• the drug is capable of providing hypoglycemic effects;
• Humulin enters the category of DNA recombinant compositions and is a two-phase suspension for injection. At the same time, it is characterized by an average duration of impact;
• since the introduction of the drug, its pharmacological efficiency will be marked after at least 30, but not more than 60 minutes;
• maximum impact will be maintained for two to 12 hours;
• the total duration of exposure will be from 18 to 24 hours.

What are the indications for use and side effects?

Side effects are a diagnosed hypoglycemia, as well as an increased degree of susceptibility.

It is often enough in the process of treatment with hormonal components, including humulin NPH, identifies the formation of hypoglycemia. If it is characterized by an aggravated form, then it may well have an appropriate effect on the hypoglycemic (aggravation and loss of consciousness), as well as lead to the patient's death.

In some diabetics, certain allergic reactions can be identified, which will be associated with skin item, swelling and redness directly in the field of implementation of the composition. Traditionally, such symptoms by themselves pass after a number of days or even weeks from the start of the recovery course.

In some cases, the presented condition does not have any connection with the use of the most hormonal component. It may turn out to be the result of the impact of external factors or incorrect injected injection. In the most difficult situations, the allergic reaction can provoke a threat to diabetic life and need to provide maximum medical intervention. In certain situations, it may be necessary to replace the hormonal component or the implementation of desensitization.

In the process of using an animal insulin, resistance, an increased degree of susceptibility to the drug, as well as lipodystrophy, can be formed.

In the process of using insulin humulin NPH, the probability of such critical consequences is almost zero.

How to apply insulin?

Humulin is unacceptable to introduce an intravenous manner. It is strongly recommended to draw attention to the fact that:

1. when prescribing the hormonal component, the dosage and the implementation mode must select an exclusively specialist;
2. this should be individually carried out for each particular patient, depending on the glycemia indicators in the body;
3. Humulin is used for subcutaneous implementation, but it is permissible to use it and intramuscularly;
4. under the skin, the drug is introduced exclusively to the region of the peritoneum, hips, shoulder or one of the buttocks;
5. in the same place, the injection of the hormonal component is permissible to put no more than once every month.

When implementing the procedure, it is recommended to use the injection devices used exclusively to use. In particular, it is not recommended to allow the penetration of the needle to the region of blood vessels, not to massage the area of \u200b\u200bthe injection after it. In this regard, it will be very important to familiarize themselves with the rules on how the composition is being introduced.

How to introduce a tool?

In order to correctly conduct an injection drugIt is strongly recommended to first implement some preliminary procedures. First of all, the area of \u200b\u200bthe injection is determined, the hands are rinsed well, and the specified space is wiping into such a napkin, which was impregnated with alcohol. After that, with the needle, the syringe is highly recommended to remove the leap cap, stretch and fix the skin. Then stick the needle and the injection.

Next, the needle will need to be removed and for a few seconds, not rubbing, press the area of \u200b\u200bthe injection with a napkin. Next, with the help of a protective outer cap, you will need to unscrew the needle, remove it and re-put the cap on the syringe knob. It is also necessary to understand that two times in a row one and the same needle is urged urgently not recommended. The bottle or cartridge should be used to absolute devastation, after which it is ejected. The syringe knobs should be designed exclusively for the individual process of use to eliminate the likelihood of complications and negative reactions.

Is an overdose possible?

Humulin NPH, like the rest medications In the presented category drugs, do not have a specific overdose. This is due to the fact that serum glucose indicators will depend on the difference during the day between the glucose indicators, the hormonal component and other metabolic states. Of course, an insulin overdose can be characterized by a truly negative impact. It is strongly recommended to draw attention to the fact that:

• hypoglycemia is formed as a result of the inconsistency between the insulin ratio in the blood plasma and energy costs consumed by food;
• for developing hypoglycemia, such symptoms such as lethargy, tachycardia, vomiting, as well as excess sweat, are peculiar;
• in certain situations, admit, with significant duration sugar diabetes Or its constant monitoring, symptoms of developing hypoglycemia can be the most different.

A slight type of hypoglycemia can be deleted through the use of glucose or sugar. In certain situations, the need to adjust the number of insulin, revising diet nutrition or changing the pace physical Loads. In the future, to exclude recurrence of hypoglycemia, diabetics will have to eat food that is saturated with carbohydrates. A truly aggravated degree of hypoglycemic state implies emergency hospitalization.

What are the storage conditions and special instructions?

Humulin NPH can be purchased at the pharmacy exclusively by the prescription of the attending specialist.

The drug is strongly recommended to be stored at temperature indicators from two to eight degrees. In this case, the hormonal component is unacceptable not only to freeze, but also to expose the sunlight, as well as heating. The opened bottle with insulin is strongly recommended to be stored at temperature indicators from 15 to 25 degrees for 28 days. Subject to the required temperature regime, the NPC will be stored at least three years.

All about medicinal interaction

Independent completion of treatment or the use of incorrect dosages (which in particular concerns insulin patients) can affect the development of diabetic ketoacidosis or hyperglycemia. As you know, the presented states are potentially dangerous to preserve the vital activity of diabetics. In a certain category of people, when applying the human hormonal component, symptoms of developing hypoglycemia may differ from the signs that are characteristic of the hormonal component of animal origin. Also, they may well have much weaker manifestations.

The transition of diabetics to other compounds of Insulin NPH or varieties should be carried out exclusively under the supervision of a specialist. The replacement of the component for the drug with other activity indicators of the production method (for example, DNA recombinant, animal) may well require the most quickly or, on the contrary, the smooth adjustment of the dosages used by Humulin NPH.

In pathological deviations in the work of the kidneys or liver, insufficient work of the pituitary gland, destabilization of the functioning of adrenal glands and the endocrine gland, the need for a hormonal component in a patient can significantly decrease. With the strong psychological tension and other pathological conditions, on the contrary, it is even more significant - there are such changes, according to experts, quite often.

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The drug humulin NPH is produced in the form of a suspension used for p / k administration. Packaging may contain: Flakes of 4 or 10 ml; 1.5 and 3.0 ml cartridges, designed for syringe knobs of type Quixpin.

pharmachologic effect

Hypoglycemic.

Pharmacodynamics and pharmacokinetics

Humulin NPH is DNA recombinant human insulin with the average exposure duration, the main effect of which is to regulate glucose . Also, the drug is manifested anabolic efficiency.

In tissues human organism (except for brain tissues) Insulin Humulin NPH activates transportation and glucose and also speeds up processes anabizm Belkov . In parallel in the liver, the drug contributes to education glycogen of glucose , stimulates transformation surplus glucose in fat , inhibits.

The initiation of insulin humulin NPH is noted 60 minutes after the administration, with the achievement of maximum efficiency in the period from 2 to 8 hours and the duration of the action within 18-20 hours.

Observed individual discrepancies in efficiency insulin depend on the choice of dose, the injection site, as well as the physical activity of the patient itself.

Indications for use

The drug humulin NPH is shown to use at:

• first diagnosed;
• sugar diabetes , in case of reading for destination;
• pregnancy on the background insulin-dependent diabetes (type 2).

Contraindications

• hypoglycemia observed at this time;
• hypersensitivity on the ingredients of Humulina NPH.

Side effects

The main side effect is hypoglycemia which in the case of severe flow can cause loss of consciousness and even death (rarely).

There is also a minimum probability of formation. lipodystrophy .

Allergic manifestations of systemic nature:

• labored breathing;
• lower hell ;
• increased;
• pulse increase.

Allergic manifestations of a local character:

• euchness or in the field of injection (as a rule, they stop over several weeks);
• hyperemia .

Instructions for the use of humulin NPH

Dosage Humulin NPH is selected individually, consistent with the patient's level.

B / in injection humulin NPH is prohibited!

Emulsion should be administered to P / K, in some cases allowed in the injection. P / k administration is carried out in the abdomen, shoulder, buttocks or hips. The location of the introduction should be alternate in such a way that for 30 days in one place there was no more than one injection.

P / k injections require a certain introduction skill and precautions. It is necessary to avoid the needles to circulate blood vessels, not massage the place of injection, as well as how to properly handle devices for the administration of the drug.

Preparation and introduction of humulin NPH

With the aim of resuspending insulin , Before using the vials and cartridges of the drug humulin NPH, it is recommended to roll in the palms in the palms and to shake (turning 180 °) to the preparation of a condition close to milk or homogeneous muddy liquid. Vigorously shake the drug should not be vigorously, since the foam formed in this way may interfere with an accurate dose set.

Flakes and cartridges need to be checked with special care. Avoid use insulin with sediment cereal or white particles, sticking to the walls or the bottom of the bottle, forming the impression of a frostite pattern.

The design of the cartridge does not allow mixing in it its contents with other insulin , as well as re-fill the cartridge itself.

When using bottles, the emulsion is gained in that insulin syringe which by volume corresponds to the input insulin (for example, 100 IU / 1 ml insulin \u003d 1 ml syringe) and introduced, consistent with the recommendations of the doctor.

When using cartridges, you need to adhere to the instructions of the manufacturer of the syringe knob to install, fasten the needle, as well as the introduction of insulin, for example, instructions on humulin NPH into the syringe knob of the Quixpin.

Immediately after the injection, use the outer cap of the needle, remove the needle itself and destroy it in a safe way, then close the handle with the cap. This procedure Provides further sterility, warns air from entering, prevents the drug leakage and its possible clogging.

Needles and syringe knobs are not subject to reuse and exploitation by other persons. The bottles and cartridges use once before the completion of the drug, after which they are thrown out.

It is possible to introduce humulin NPH in combination with. For what, in order to prevent the penetration of the bottle insulin more prolonged action, first in the syringe are gaining insulin short action. This mixture is recommended to enter immediately after mixing. For accurate dosage two insulinov can use different syringes.

Overdose

As such a specific overdose of Humulin NPH no. Symptoms are considered manifestations hypoglycemia accompanied by elevated, lethargy, headache, pallhy skin cover shivering , vomiting.

In some cases, the symptoms preceding hypoglycemia ( long diabetes Or its intensive control) may change.

Manifestations hypoglycemia easy degree, as a rule, are stopped by oral administration sahara or glucose ( ). In the future, you may need a diet regime adjustment, dose insulin or physical exertion.

Adjustment hypoglycemia middle severity is carried out by p / k or in / m injection, with further oral administration carbohydrates .

Manifestations heavy hypoglycemia may be accompanied neurological disorders or convulsions which are localized in / in injection concentrated glucoses (dextrose ) or p / k or per / m introduction glucagon . In the future, in order to prevent the repetition of symptoms, we need to eat food rich carbohydrates .

Interaction

Hypoglycemic Efficiency of Humulina NPH decreases with parallel reception, hormones thyroid gland, glucocorticoids , tiazid Diuretikov , tricyclic antidepressant , Diazoxide .

Combined application ethanol , hypoglycemic drugs (oral), salicylate , Mao inhibitors, sulfanimide , beta adrenoblocators Enhance the hypoglycemic effects of humulin NPH.

For emotional overvoltage and in some pathologies there may be an increased need for insuline .

Sometimes the adjustment of the dosage is advisable when changing or increasing physical Loads .

In some patients, in the case of use insulin man , symptoms preceding hypoglycemia may differ from those when used animal insulin or be less pronounced.

Normalization of plasma glucose levels due to intense, leads to the disappearance of all or some manifestations hypoglycemia What you need to inform the patient.

Symptoms of the coming hypoglycemia can be smoothed or change in case of parallel use beta adrenoblocators , diabetic neuropathy or long.

In some cases, local allergic manifestations can develop for not related to the effects of the drug reasons (for example, skin irritation Due to the use of a cleansing agent or incorrect injection).

Rarely, systemic allergic reactions may require immediate therapy (conducting desensitization or replacing insulin ).

because of possible manifestation Symptoms hypoglycemia it is necessary to take all precautions when performing dangerous work and driving a car.

Analogs

• Insulin Fereyn EFS ;
• Monotdard HM. ;

The genetically engineered insulin allows to achieve significant results of control of sugar disease in patients with 1 type of diabetes, pregnant women and nursing mothers, patients with diagnosis of SD 2, even on the background of insulin resistance or lack of effect from standard sugar therapy.

The effect of the analogue begins an hour after subcutaneous maintenance, the order of 16-20 hours continues and reaches the maximum in the range of 4-8 hours. The presence of the action complicates therapy, but this deficiency is easily leveled with a competently selected diet, compliance with the time mode, adequate physical activity planning.

Usually hormone is used 1-2 times a day depending on the level of glycemia, individual sensitivity to the drug. Mixing the medication (even in one injection) with short analogues of the same manufacturer, thus, decreases the number of injections per day.

Humulin Regular

Refers to short insulin. Begins to work in half an hour after administration (the injection is placed in 15-30 minutes before meals), achieves maximum activity after 1.5-3 hours, it has a residual effect on the glycemia of 5-7 hours.

The medicine is perfect for compensation for patients leading a measured lifestyle that complies with the approximate mode of the day. It is recommended when carrying pregnancy against the background of the existing chronic sugar disease. It is not bad for the elderly, as well as all patients, the course of the disease of which is complicated by concomitant diseases.

Often therapy of insulin humulin regular starts during the preparation of patients to serious surgical interventions or in the period of sharp infectious diseases. As a rule, good results of therapy become a significant factor in order to maintain this treatment regimen and after these therapeutic measures.

Such high-quality analog is rarely serious side effectsis easily transferred. The occurrence of lipodystrophs is usually associated with an elementary impairment of technology, and severe hypoglycemia appear only due to the overdose of the drug. The transition to humulin should be regularly carried out only under the control of a qualified physician, because it may be necessary to make a serious adjustment of the usual insulin-therapy scheme. The ideal option is the selection of the right dose in a specialized hospital.

Increase / reduction The number of injections and their volume can occur against the background of stress, diseases, physical activity. Also important is the place selected for injections, individual sensitivity to the active substance.

Humulin MZ.

Also refers to the group of analogue of the average duration of action. It has a rather sharp start of work, because after an hour (sometimes there is enough 30 minutes) after entering the skin, it develops good activity, the maximum occurs after 1.5-8 hours, remains in the body up to 15 hours. Entered only subcutaneously / intramuscularly!

The suspension contains 30% Humulin Regular, the rest falls on the humulin NPH. To change the profile of the drug, it is recommended to track the individual reaction to the change of injection site, increase / reduce the gap between injection and food intake.

The use of medication obliges the patient to carefully refer to the compliance of the storage rules and the introduction of this insulin. Before applying the bottle, you need to ride between the palms (about 10 times) for uniform mixing. The finished composition should acquire a muddy-white (milk) color, homogeneous consistency.

To achieve a worthy compensation, a 3-hook, daily diet, a day mode adjusts to the profile of an artificial hormone as possible to achieve.

Storage

All drugs of this manufacturer are stored in the refrigerator before opening. After the start of using the bottle should be kept when room temperature. Freezing leads a medicine in a non-working condition. The shelf life of the open analog is just 4 weeks.

Handle syringe uses the same as for (Humapen, Humapen Lucsura). It is allowed to use disposable syringes.

Remember, any methods of therapy in endocrine pathologies can only be applied after agreeing with the attending physician! Self-treatment can be dangerous.

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Medicine Humulin NPH Instructions for use describes as a drug adopted during diabetes. It acts as a substitute for insulin in people with diseases of the pancreas. Khumulin is appointed by a doctor with a shortage of this hormone in the patient. How to make a medicine?

Release form and appointment conditions

Humulin NPH is sold in the form of injection fluid. 1 ml of the medicine contains 100 meters. The suspension includes about a dozen secondary components. Packaging medication contains:

• bottles with a suspension of 4 to 10 ml volume;
• katridges are 1.5 and 3 ml for insulin syringe knobs of the type of quicpen.

Humulin is a DNA recombinant human Insulin, designed to regulate the metabolism of sugars in the body. The hormone moves the glucose and amino acids, increases the absorption rate of the protein. In the liver, the medicine transforms glycogen from glucose, and its excess converts into fat. The drug begins to act in an hour after applying. It becomes most effective after 2-8 hours, the duration of the drug action is up to 20 hours.

The use of medication is possible with the following diseases:

• diabetes mellitus if insulin therapy is needed;
• insulin-dependent diabetes during pregnancy.

It is not necessary to prescribe a drug yourself. This should do a doctor, explaining the patient how to calculate the dosage.

When can not be used?

Contraindications for the use of humulin a little. These include: hypoglycemia, which is fixed before taking the drug, and individual sensitivity to components. The main negative effect is hypoglycemia, which can cause fainting and even lead to death, but such by-effect It is extremely rare.

You can meet allergic reactions more often:

Sometimes local allergic manifestations may occur, such as hyperemia, swelling. In case of overdose, the following organism reactions arise:

The hypoglycemia must be monitored very carefully, since in certain cases, symptoms may change. To eliminate the pathology of a light degree, a small dose of glucose can be taken. Next, you will need to adjust the mode and diet, as well as physical exertion. For middle degree Hypoglycemia introduced glucagon in the form of injection and oral administration is carried out. The severe form of the disease can be characterized by a coma, cramps, disorders of the nervous system.

How to apply the drug?

The dosage of the humin must be selected strictly individually. The drug cannot be administered intravenously. The most common way of infusion is under the skin, sometimes intramuscularly. For subcutaneous administration, the area of \u200b\u200bthe thighs, buttocks, shoulder, belly are suitable. During the month, more than 1 injection can be done in one place. Since for subcutaneous injections The drug requires certain skills, it is better to charge this procedure for medical personnel at the first time. When the medication is introduced, it is important not to get into the vein and not to rub the area of \u200b\u200bthe injection.

Katridges and vials before use you need to ride 10 times in the palms and shake so that the suspension gets a matte tint or color close to the milk. Cropstically to shake the contents of the bottles cannot be, since the resulting foam will make it difficult to accurate dosage determination. Preparing insulin for injection, you need to carefully check the contents of the ampoule. If it is noticeable lumps, white precipitate, pattern on the walls like frosty, such a drug cannot be used.

For an injection, it is necessary to take the syringe of the volume that corresponds to the required dosage. After the procedure, the needle is recommended to destroy and close the handle using the cap. This is necessary in order to preserve the sterility of the drug, prevent the falling of foreign components and air into the vial. Use the needle or syringe for the second time it is impossible. Store the drug is needed in a dark cool place. After the start of using the bottle, you can keep no more than a month.

With the introduction of Humulina NPH, some features of its application should be taken into account:

• dependence on insulin in the patient decreases if the functions of the kidneys, adrenal glands, pituitary gland, the thyroid gland are affected;
• in stress, the patient requires more insulin;
• the dose adjustment is necessary when the diet is changed or at exercise;
• allergies arising from a patient may not be associated with insulin intake;
• sometimes the introduction of the drug may require emergency medical care.

Due to the risk of the development of hypoglycemia after injection, it is necessary to refrain from driving vehicle and managing mechanisms.

The effectiveness of the drug is reduced if it is parallel to take oral contraceptives, thyroid hormones, antidepressants, diuretics, glucocorticoids. The action of the medication is enhanced if you drink simultaneously with it:

• ethanol;
• hypoglycemic drugs;
• salicylates;
• beta adenoblocators;
• sulfonamides;
• inhibitors of Mao.

Cloofelin and reserpine can generate hypoglycemia symptoms.

Analogs and prices

The average price for the packaging of the humulin NPH varies within 1000 rubles. In the absence of a drug in pharmacies, you can use one of its analogues. It:

1. Insulin-Fereyn EFS. It has a semi-synthetic human insulin. The medicine is produced as a solution for subcutaneous injections.
2. Monotdard nm. The drug refers to a group of insulin with an average duration of action, produced in the form of a suspension of 10 ml in the vial.
3. Humodar B. contains insulin of a person, is also produced by 100 meters in 1 ml.
4. Pensulin SS is another structural analogue of the average duration.

Among the substitutes of Humulina, NPH allocate:

Modern pharmacology is ready to offer a large selection of insulin drugs with diabetes. However, due to the differences in the composition and duration of action, only a qualified specialist should be equally determined by the dosage in accuracy.

Composition and form of release

Insulin Humulin NPH, for injection Contains recombinant human insulin 100 me / ml, 3 ml in cartridges, in a package of 5 pcs.

pharmachologic effect

It has a hypoglycemic effect. Humulin NPH It is an insulin drug average duration. The beginning of the drug is 30 minutes after administration, the maximum effect of action is between 1 and 8.5 hours, the duration of action is 14 to 15 hours. Individual differences in insulin activity depend on such factors as a dose, the choice of injection site, the physical activity of the patient and others.

Indications

Sugar diabetes I and II types.

Contraindications

Hypoglycemia, increased sensitivity to insulin or one of the components of the drug.

Method of application and dose

The dose determines the doctor individually depending on the level of glycemia. The drug should be administered to the p / k, in / in, possibly an introduction. The drug is injected into the shoulder, hips, buttocks or abdomen. The injection site must be alternate so that the same place is used not more than about 1 times / month. When the Introduction it is necessary to exercise caution to avoid getting into blood vessel. After injection, you should not massage the place of administration.

Side effects

Allergic reactions: Local allergic reactions are possible - hyperemia, edema or itching at the injection site (usually stopped within a period of several days to several weeks); Systemic allergic reactions (less often arise, but are more serious) - generalized itching, difficulty breathing, shortness of breath, decreased blood pressure, pulse increase, increased sweating. Heavy system cases allergic reactions May be threatening for life.

Others: The likelihood of the development of lipodystrophy is minimal.

Rules of preparation and administration of the drug

Cartridges Humuminulina NPH Before use, it should be done between the palms 10 times and shake, turning 180 ° also 10 times to resuspend insulin to the state until it acquires the type of homogeneous turbid liquid or milk. Should not be vigorously shake, because This may lead to the appearance of a foam, which can prevent the correct dose set.

Cartridges should be carefully checked. You should not use insulin if there is flakes in it after stirring, if the liner or walls are riveted with solid white particles, creating a frosty pattern.

The cartridge device does not allow you to mix their contents with other insuls directly in the cartridge itself. Cartridges are not intended for re-filling.

When using cartridges, follow the manufacturer's instructions for refueling the cartridge and fastening the needle. The drug should be administered in accordance with the manual of the manufacturer of the syringe knob.

Using the outer cap of the needle, immediately after the introduction, turn out the needle and safely destroy it. Removing the needle immediately after injection provides sterility, prevents leakage, air enter and possible needle clogging. Then put the cap on the handle.

Needles should not be reused. Needles and syringe knobs should not be used by other persons.

Humulin NPH can be administered in combination with Humulin Regular. For this, a short action insulin should be chosen in the syringe first to prevent ingress of insulin in long action. It is desirable to be prepared simply after mixing. To introduce an accurate amount of insulin of each type, you can use a separate syringe for Humulina regular and humunin NPH.
Insulin syringe should always be used, which corresponds to the concentration of insulin insertion.

Storage conditions and shelf life

The drug should be stored in the refrigerator at a temperature of from 2 ° to 8 ° C, prevent freezing, take care of the direct impact of light. Shelf life - 2 years.

The drug in the vial or in the cartridge should be stored at room temperature (from 15 ° to 25 ° C) not more than 28 days.