Diabetes - serious diseaseFrom which, unfortunately, it is impossible to get rid of completely. As is known, on the background of the ailment there is a violation of hormonal secretion in the tissues of the pancreas. And quite often, patients are prescribed synthetic insulin "Isofane". This substance controls blood sugar levels, ensuring the normal operation of the whole organism.

Of course, patients are interested in any additional information about the preparation. How does semi-synthetic insulin "Isofane" affect the body? Instructions, contraindications, possible complications on the background of therapy is important momentswhich will be reviewed in the article.

Form release

It's no secret that diabetes common and dangerous diseasewhich requires the use of various drugs, including insulin. "Isofane" - the trade name of the drug, which is a finished mixture of semi-synthetic hormones. The medicine is produced in the form of a solution for subcutaneous administration. The drug is sold in 10 ml glass bottles with a dosage of 40m / ml. For the preparation of the solution used purified water for injection.

If other medications with the same composition and properties as insulin "Isofane". It is synonyms - this is "insuma", "Protafan" and "Himulin". It is worth it to immediately say that such drugs are released only by prescription or their endocrinologist gives them.

What properties is the drug?

Insulin "Isofane" is a semi-synthetic hormone, which has the same properties as the substance produced by the pancreas of man. The drug reduces the amount of glucose in the blood due to amplification of lipogenesis and gluconeogenesis processes.

Synthetic hormone interacts with insulin-dependent cell membrane receptors, activating metabolic processes inside the cell. After taking the drug, there is an activation of the synthesis of some enzymes, including glycogenesintheases, piruvatatinase and hexochinases.

The effect can be observed after 1-1.5 hours after the introduction of the solution. Depending on the dose and features of the patient's body, the maximum activity of synthetic insulin is observed 4-12 hours after the reception. The effect is kept from 11 to 24 hours.

Main reading for use

The drug "Insulin-Isophane" is used in a diabete of a second type (insulin-dependent form). It is also used for temporary insulin therapy. Sometimes such treatment is required at diabetes of the first type. For example, the introduction of the solution is recommended for patients in cases where they do not give the desired effect.

The introduction of human insulin is required after some surgical interventions. This medicine is also used in gestational diabetes mellitus (this form of the disease develops in women during pregnancy). Introduction of insulin by future mothers are recommended if diet therapy does not have the desired effect.

Semi-synthetic insulin "Isofane": instructions for use

With sugar diabetes of second type, patients need life therapy. Dose, daily rate, an introduction schedule - all this is determined by the attending endocrinologist. It is important to clearly follow all the prescriptions of the specialist. There are some general rules for using the insulin-isofan medication.

• The solution is designed exclusively for subcutaneous administration. In rare cases, the doctor may recommend introducing medicine intramuscularly. Intravenous injections are prohibited.
• The drug cannot be entered into the same place.
• First you need to shake the bottle several times, after which you get the required amount of solution into the syringe (the dose is selected individually).
• Injection must be carried out immediately after filling the syringe.

The bottles with a solution are stored in the refrigerator at a temperature of 2-8 degrees Celsius. Before administering the medication, you need to measure the level of glucose in the blood. In no case cannot be used the drug if you have noticed the clouding of the solution, the formation of precipitate on the walls of the bottle.

Are there contraindications?

The drug has some contraindications - this data contains instructions for use. Insulin Isofan is not prescribed patients with hypoglycemia. Contraindications include insulin, as well as hypersensitivity to the components of the drug components. It is worth noting that sometimes even changing the injection site may entail an allergic reaction and the emergence of other side effects.

Possible side effects

This drug is needed to patients with insulin-dependent forms of diabetes. Nevertheless, therapy is associated with some complications. What violations can the use of Medicine "Isofan-insulin" can lead to? The instruction contains the following information:

• The list of most frequent disorders can include allergic reactions that are accompanied by the appearance of rash and urticaria, sharp drop arterial pressure, increasing body temperature and adhesions.
• The dangerous consequence of insulin therapy is hypoglycemia - a condition characterized by a decrease in blood sugar levels. Symptoms include pallor of skin, rapid heartbeat, anxiety, sleep problems, constant feeling of hunger. A similar violation is usually associated with incorrect dosage or non-compliance with the doctor's prescriptions. In the most difficult cases, hypoglycemic coma develops.
• The beginning of treatment in some patients is associated with violations. Hard to worry about this is not worth it, because in most cases such side effects Pass themselves.
• To the list possible complications Immunological reactions can be attributed, which also pass as the body adapting to this form of insulin.
• At the beginning of the drug intake, skin reactions are possible, including redness and itching. They also pass by themselves.
• Introduction of too large doses of the drug fraught mental disorders. There is an increased irritability, anxiety, changes in behavior, the development of depression.

It is worth understanding that it is necessary to introduce insulin "Isofane" according to the schedule compiled by the doctor. Injection passage is accompanied by the development of diabetic acidosis.

Insulin "Isofane": Analogs

In modern medicine to control the level of glucose, synthetic human insulins (short and middle exposure) are used, analogs of the human hormone, as well as mixtures. Of course, the pharmaceutical market offers a lot of drugs that help temporarily eliminate symptoms of diabetes.

The list of analogues can be attributed to such medicines as "Aktrafan", Biogulin, "Diaphan". In some cases, patients recommend taking Protafan preparations, "Humodar", "Pensulin". Not bad also are the insulins "Basal" and "Fereyn". It is worth understanding that the hormones are serious drugs, and it is impossible to use them independently. Only a doctor can choose an analogue and determine the dose. For example, the presence in the solution at least one additive in some patients may cause a massive allergic reaction to anaphylactic shock.

Information on interaction with other medicines

Before starting therapy, you must provide a doctor about the medications taken. The effect of synthetic insulin is enhanced by simultaneously admission with sulfonamides, helium and anabolic steroids, Mao inhibitors, non-steroidal anti-inflammatory drugs. The hypoglycemic effect is more pronounced against the background of the simultaneous use of the drug "Isofane" with ketoconazole, cyclophosphamide, quinine, chlorochinin, quinidine, drugs containing lithium. By the way, on the background of therapy, it is not recommended to use alcohol, since ethanol reinforces the effect of synthetic insulin.

Estrogen, oral crossing, glucagon, heparin, thyroid hormones weaken the effect of the drug. The same can be said about Nicotine, marijuana, morphine, some diuretics (in particular, thiazide and loop), tricyclic antidepressants.

In any case, it is worth understanding that without the knowledge of the doctor you can not change the dose or an insulin reception schedule. About the appearance of deterioration and adverse Reactions We must immediately inform the attending endocrinologist.

Absolutely for all trouble there is its own reason. So the bump from the injection in the buttock just does not occur. In violation of the technique of formulation of intramuscular injection, an inflammatory process can be launched, leading to a seal in the place of injection, redness, pain and swelling of this area. We list the main, often encountered, the reasons for the appearance of "cones":

1. Accelerated drug administration. In this case, the drug simply does not have time to evenly distribute in the muscle tissue, remains in one place, forming a seal from the injection, which can incere with time.

2. Insufficient needle length. Some people who put injections at home or with loved ones are mistakenly believed that it is best to use the most thin needles, and use insulin syringes to injections into the buttock. The long needle does not reach the muscle, and medicinal substance Entered in the subcutaneous fat layer. The same effect will be if a syringe is taken with an adequate needle long, but during the needle procedure entered less than half.

3. Tension muscles. Since childhood, we all remember the phrase of the nurses before making the injection of the "Relax Pop". In the tense muscle, the medicine will not be able to quickly solve and infiltrate after the injection can be formed, by simple - "bump". Also, the main and fairly serious danger of injection into the tense solid muscle is that the needle can be broken, and then it will have to extract a chip surgically. Therefore, during the injection, relax and do not agree to put injection standing.

4. Some drugs have an oily structure. They must be introduced into the muscle slower than others, it is desirable to heat them before the body temperature.

5. It is rarely encountered allergic reaction to medicines. Allergic injection infiltrate has its own characteristics: the rapidness of the occurrence, swelling and redness of the injection site, sometimes itching. In such cases, you need to immediately notify your doctor so that he accepted necessary measures By correction of therapy.

Bump after injection how to cure

Sugar level

At home, you can successfully remove cones from injections on the pope. However, if you have such symptoms as a local temperature increase at the injection site, expressed swelling, redness and painfulness of this area, in no case do not self-medication, immediately ask for advice to the surgeon. In such cases, there is a risk of the development of abscess, which is treated extremely surgically. To do not bring it before, the seal after the injection is necessary to start treated in a timely manner.

How to treat bumps from injections:

1. Carefully massage the injection area to improve local blood circulation and accelerate the absorption of infiltrate.

2. The simplest and most well-known means - iodine mesh. Draw the meshes with a cotton waller dipped in iodine solution. It is necessary to make this procedure 2-3 times a day.

3. The following means - applying a juicy cabbage sheet or aloe leaf at night (need to cut a sheet and attach a juicy side). It is known for this method from our grandmothers, it is really effective, and many doctors recommend it for the treatment of inflammatory post-delicious infiltrates.

4. Compress with "Dimeksid" divorced with vodka in a ratio of 1: 4. It is advisable to lubricate the skin with anti-inflammatory cream

Despite its unpleasant specific smell, "Dimeksid" is very effective tool and, moreover, it is inexpensive, which is also important

5. Local use of trocserutin or heparin ointments. It will remove the inflammation and acknowledge the zone with a shishk. Effective and convenient in the use of gels are also offered, also made on the basis of heparin.

6. Excellent proven herself in treatment inflammatory processesWhat are the "bumps" from injections, homeopathic ointment based on the grass "Traumel C". Due to its unique composition, this ointment is able to eliminate the bumps after injections on the buttocks. Similar effect possess others homeopathic ointments Based on Arnica.

The folk tips and drugs listed above and drugs at the timely beginning of treatment will help get rid of "cones" from injections and avoid unpleasant complications.

And, finally, I want to say, please entrust the recommendations of qualified doctors and use the Time Time. It is not necessary to look for on the Internet and test dubious advice to apply a piece of sala or compress from urine. Unless as a joke! Be healthy!

You still seem to cure diabetes impossible

Judging by the fact that you are currently reading these lines - the victory in the fight against the high level of blood sugar is not yet on your side ...

And you already thought about inpatient treatment? It is understandable, because diabetes is a very dangerous disease, which in late treatment can end with death. The constant thirst, stripped urination, the fuzzy of vision ... All these symptoms are familiar with you not at the break.

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Etodiabet.ru »All about insulin» Important information about insulin

Folk remedies against cones caused by injections

Popular treatment with such a problem is very effective and can quickly eliminate bumps caused by injections.

• An effective means for getting rid of cones after injections is a propolis tincture, which can be easily purchased in any pharmacy. For the treatment of the area of \u200b\u200bthe skin around the bumps is abundantly lubricated with children's cream and impose a cotton disk, moistened with tincture onto the seal. Fix it with the help of a leucoplasty. On the day they make 1 procedure for a duration of 3 hours. The course of treatment is 10 days.
• The cabbage leaves and honey are perfectly saved even from the allied cones. To carry out therapy, it is necessary to take 1 cabbage sheet and repel it with a hammer. After that, on the surface of the sheet, lay 1 teaspoon of honey and smeared slightly. The honey side is applied to a chish and fixed with a patch. Leave cabbage all night. Such treatment continues, depending on the resorption rate of the cones, from 7 to 14 days.
• Aloe is a very effective medicine against cones. In order to apply the plant in the treatment, it is required to cut 1 sheet from it and put in the refrigerator for 24 hours. After that, it is necessary to prepare Cashitz from the leaf. It is applied to the scene of the bumps, cover with top polyethylene and, fixing the plaster, insulate the wool cloth. This compress is placed on the whole night. Conduct treatment until the bump is dispersed, but not more than 15 days. If during this time the neoplasm did not disappear, you should seek medical help.
• Salted cucumbers - beautiful tool against seals formed by the fault of Ukolov. In order to use them as a medicine, it is necessary to take 1 cucumber, cut it into thin circles and attach them into several layers to the seal. From above, the cucumber is covered with polyethylene and fixed the leukoplasty. The action of the compress is lasting throughout the night. In most cases, there is a noticeable improvement in the patient in the morning. All treatment takes from 5 to 7 days.
• Banana peel is also an excellent medicine against cones left by injections. For treating from the peel, a piece is cut off, the size of which will allow fully closing the seal, and applied to the patient to the inside. Fixing the peel with the plaster, it is left overnight. This treatment continues for 10-14 days. In most cases, the bump begins to decrease in size after 3 days of therapy.
• The cranberry compress is also very effective when the seal caused by the shift. To carry out 1 tablespoon of cranberry berries, ticks and laid out on a folded 2 times gauze. Then the means is applied to the affected area, covered with polyethylene, fixed with the plaster and leave for 12 hours. Make this compress from the evening. The duration of treatment directly depends on the rate of recovery.
• Lilac leaves also quickly eliminate bumps. For treatment, it is enough to simply apply a raised leaf of the plant to the affected place and replace it every 3 hours. At night, the leaves are put in 3-4 layers. Usually, recovery comes in a week.

Homemade means

Practical, effective, convenient tools for the treatment of seals after injections are always in the arsenal of any mistress. Popular folk Methods They will help to get rid of the unpleasant consequences of insulin therapy. These recipes are tested by patients. diabetes. They provide an effective confirmed result.

Honey in pure form and honey pellet

Sick place can be lubricated with natural honey.

Natural natural medicine will come to help in the fight against insulin cones. Honey can be smeared compacted places, leaving for two hours. And from it prepare a healing pellet. For this take an egg, on a tablespoon of honey and butter. Flour poured on the eye. We knead a ridicule, but also a loose cake. It is stored in the refrigerator. Each time it pinch a piece and make a circle. Its diameter must correspond to the size of the seal, and the thickness to be up to a centimeter. The circle is applied to the seal and fix the bandage or bandage. It is left overnight or held within an hour.

How to use potatoes during seals?

Potatoes are used to treat insulin cones in raw form. For this, a well-washed raw potatoes are cut longitudinally in half. After that, each half is applied to subcutaneous seals. Potato juice will have a useful effect, softening and reduce the bumps. From the purified tuber, they are preparing Cashitz, for this rubbing it on a shallow grater. Lay it on the dressing, and make compress.

Cucumber in the treatment of cones

Salted cucumber helps to cope with seals at the injection site. It is finely cut with circles. The rings are applied with rings of the appropriate size and attached with a patch. Such compress is kept for a long time, make on the night. By morning the seal disappear or significantly reduced in size. If necessary, the procedure is carried out on the next night.

Other homemade assistants

Capported leaf fights well with such formations.

Cabbage leaves are an excellent agent for the treatment of insulin infiltrates. Fresh leaves are cut slightly, beamped with a hammer, so that they let me down. They are applied to the bumps up to 3 times a day. You can add honey if there is no allergies to its components. The only minus cabbage is the inconvenience of moving. Therefore, it is well imposed in the evening before bedtime, or during the planned holiday. Effective, proven recipe - Aloe leaves. For treatment, the bottom leaves of the plant are needed. They are cut and leave in the refrigerator for a day. Then wash, remove sharp edges, and beat off with meat hammer until the healing cashem turns out. It is applied to the bandage and recorded on the bump area.

Medical treatment of cones

For medical treatment Cryes use multicomponent ointments. They are resolving, anti-inflammatory and disinfecting effect.

Cones from injections on hand, the outer surface of the thigh or buttocks can be cured using proven and confidence in ointment:

How to apply ointment:

The ointment of Vishnevsky or the balsamic liniment is superimposed by a compress for 3 hours, once a day. For treatment, you need to make procedures for one or two weeks.

Heparina ointment and throksevazine make a massage. Massage with ointment is necessary, strictly in the direction of the muscle.

Magnesium sulfate compress

Magnesium sulfate is an inorganic substance widely used in medicine. In the pharmacy you can buy an already ready solution for magnesium sulfate or a mixture to cook it.

For the treatment of cones, we make a compress for the night: you need to moisten the bandic or cotton swab in the solution of magnesium sulfate and put on the conex. Top to cover with a compress with a food film and fasten a gauze bandage.

Iodine mesh

The most affordable, simple and common way to treat and prevent cones from injections. Take cotton wand I smelly smoke it in food and put the seal from the injection mesh to the place. It is necessary to make this procedure three times a day.

For treatment, iodine mesh is used in a complex with other methods, for a better result. During the course intramuscular injections The iodine mesh is recommended to do for preventing cones.

How to remove after insulin cones

The main rule for patients with diabetes mellitus is not to introduce a long insulin in the same place. It is recommended to alternate zones for injections, for example, the area of \u200b\u200bthe abdomen or hips to replace the buttocks and the blades. If it does not work yourself to prick in new places, it is better to seek help. To dissolve compacted infiltrates, it suffices to leave the place of their location without injection impacts for a month, as well as follow the rules of personal hygiene. In this case, use disposable syringes as it should be, not extending their service life. For the treatment of seals, use pharmacological resorption drugs, physiotherapy, vegetable and natural agents.

Why bumps appear from insulin injections

A sugar hormone is necessary to the patient several times a day, so the patient does not have the opportunity to often change the place of injections, which leads to the appearance of painful tubercles. Lipodystrophic cones represent a seal of adipose tissue, and have the type of elevation, lifting above the skin. There are still lipoatrophy - small compacted depressions in places of injections. The main reason for the appearance of cones is a repeated use of insulin needles. Patients save syringes, and more than a week make injections with the same needle. With them long use The end is dulled and injured the epidermis. In the subcutaneous layer there is inflammation.

Why after the injection the bump appeared

With a proper enclosure, the medicine appointed by the doctor falls into the muscular layer, quickly is absorbed and passes through the tissues of the body, having a healing effect. If a bump appeared on the spot of the injection and is not resolved for a long time, this suggests that errors are allowed when conducting the injection procedure.

Why on the buttock can form a bump from injections:

The nurse introduced the drug too quickly.
The syringe has an inappropriate needle size. This means that the needle is shorter than it should be. In this case, the medicine is not in the muscle, but in the subcutaneous layer of adipose tissue, where it is very difficult to solve it - hence the seal.
Unprofessional procedure. In which the needle also not introduced deep enough and did not get into the muscle. This happens when the injection makes someone from family members, regrets the patient and is afraid to deliver pain.
Muscle overvoltage

During an injection, it is important to relax muscles. But now in the procedural office usually do not offer patients to lie, which is right, and make injections standing

Once in the tense muscle, the medicine is not distributed evenly, and the resulting hematoma appears.
Oil injections. Before the procedure, the oil solution must be warm and introduced very slowly. If these rules are not complicing, there is a complication in the form of painful seals.
Crightening cotton. It is believed that the use of cotton reduces pain from injections. The needle in this case is introduced at right angles, quickly and sharply. And, as a result, the medicine is also injected too quickly, and the drug does not have time to distribute uniformly.
Damaged blood vessel. At which there is some amount of blood. At this place appears bloating, redness and seal.
Allergy to the introduced drug. In this case, besides the appearance of the bump you will be disturbed itching, redness, temperature is possible.
Fit into nervous endings. With incorrectly performed procedure, you can get into sedal Nerve. In this case, you can feel numb in the buttock, legs.
Infection. An non-sterile tool, the needle contact before administration with any surfaces lead to the path in the fabric of pathogenic microorganisms. As a result, inflammation and sepsis. The symptoms of sepsis, besides the bumps, are burning, redness, severe pain, purulent discharge, high temperature.
Increased muscle sensitivity. This is a satisfied rare phenomenon, but in this case the muscles are sharply reacting to any intervention. As a result, the injection place is formed connective tissuewhich looks like a scar and seal.

About "Isophane" in diabetes

In the process of treating such a disease, like diabetes mellitus, a sufficiently large number of various drugs are applied. One of them is insulin "Isofane", which is a drug with an average duration of the duration of the impact type. What kind of composition, there are contraindications and other trifles further in the text.

About the composition

Insulin "Isofane" is obtained at active application Such technologies like recombinant DNA. This is one of the most modern methods. It is known to ensure the maximum possible effect in the process of use with diabetes mellitus of the first and second type.

Such a composition is a real guarantee that insulin "Isofane" will affect the organism of diabetics in the most positive way. In this regard, it is necessary to note some information on pharmacological impact.

On pharmacological effects

On pharmacological nuances

The duration of the effects of drugs of the presented insulin mainly depends on the suction rate. The suction rate is directly dependent on certain parameters. For example:

• dosage;
• method;
• implementation area.

In this regard, the impact profile, which is determined by insulin "Isofane", is subjected to serious fluctuations not only from a variety of people, but also at the same person. The averaged data after subcutaneous implementation indicate that the start of exposure occurs after an hour and a half, the maximum possible effect begins to form in the interval between the four and 12 hours, the duration of exposure reaches 24 hours. That is what can be said about insulin "Isofane".

The degree of completeness is determined not only by the suction, but also the beginning of the effect of the drug, as well as the introduction site (the region of the peritoneum, hips, buttocks), dosage (the volume of the component being introduced), the insulin concentration in the drug and many others. The same insulin "Isofane" is distributed by the human tissue is not identical enough, moreover, it does not have a property to penetrate the placental barriers, as well as in breast milk. Destruction occurs with insulinase exclusively in the field of liver and kidneys. This type of insulin is also displayed using kidneys, it falls from 30 to 80%.

About dosage

How to decide on the dosage?

Insulin "Isofane" Human should be administered exclusively under the skin. The dosage is determined by a specialist individually for each of the patients, which is done on the basis of blood sugar ratio. The average daily dosage of the drug is experiencing oscillations from 0.5 to 1 IU per kg. It also depends on the individual characteristics of the organism of diabetics and the ratio of blood sugar.

Insulin "Isofane" The human most often is introduced under the skin in the thigh area. By themselves, the injections are more than permissible to do in the front wall of the abdominal region, one of the buttocks or to the area of \u200b\u200bthe specific shoulder muscle. Temperature indicators of the injected drug should be in accordance with the room.

About Precautionary Measures

In the process of using any drug should take into account precautions. So, using insulin "Isofane" Human recommended:

1. change the areas of injection within the boundaries of one anatomical area. This will make it possible to prevent the formation of lipodystrophs of various genesis;
2. taking into account insulin therapy, it is recommended to continuously monitor the ratio of blood sugar.

In addition, it should be borne in mind that the causes of hypoglycemia, in addition to significant excess of insulin, it may be: replacement of the drug, passing food use, vomiting and other disorders of the gastrointestinal system, changing the degree of physical activity in any direction.

Also, there may be affected by diseases that reduce the need for a hormone (destabilization of the work of such organs such as liver and kidney, hypo functioning of adrenal cortex, pituitary gland or endocrine gland).

How to avoid hyperglycemia?

The use of improper dosage or interruption in the introduction of insulin, especially those who have encountered sugar disease The first type can trigger the occurrence of hyperglycemia. Most often, the primary manifestations of hyperglycemia begin to form at the growing, for several hours or even the day.

They imply the formation of thirst, urination, and other symptoms. Also, for additional caution, it is necessary to remember the contraindications that are reduced to an increased degree of sensitivity and hypoglycemia.

Thus, the use of such an insulin of human type with an average exposure duration called "Isofan" should be carried out in accordance with the recommendations submitted. It will be the key to the maximum possible effect With such a disease, like diabetes mellitus.

Modern pharmaceuticals offers many medicines aimed at treating diabetes.

Medicines based on new substances are being developed to ensure normal life as many patients as possible. Among these funds should consider such a drug as insulin isofane.

General information, reading for use

The means belongs to the insulin group. The main function is the fight against manifestations of sugar diabetes insulin-dependent form.

Made in the form of an injection suspension, the current component of which is human genetically engineering insulin. The basis of its development is the technology of recombinant DNA. The drug is distinguished by the average life expectancy.

Like most drugs of this group, Isophan should only be used on the recommendation of the doctor. We need an accurate dose calculation so as not to provoke the attack of hypoglycemia. Therefore, patients must clearly follow the instructions.

Start using this tool only if necessary. The attending physician is usually a survey to make sure that such treatment is appropriate and in the absence of contraindications.

He is prescribed in such situations as:

• type diabetes type 1;
• type 2 diabetes (if there are no results from using other medicines with the hypoglycemic effect or if these results are too small);
• development of diabetes due to pregnancy (when the level of glucose is not amenable to correction using a diet).

But even the presence of an appropriate diagnosis does not mean that this drug must be used. He has certain contraindications, although they are a bit.

A strict prohibition concerns only patients with individual intolerance to this medication. It is also necessary to exercise caution when selecting dosage patients with increased tendency to hypoglycemia.

There are several drugs based on isophane substance. In essence, this is the same drug. These drugs are inherent in the same properties, they have the same side effects and contraindications, differences can be observed only in the number of main ingredients and in the trade name. That is, these are drugs synonyms.

Among them can be called:

• PROTAFAN;
• Humulin;
• Arise;
• General;
• Insuran.

These means are analogs of isophane in composition. Despite their similarity, the same patient may have difficulties when using any of them, and when choosing another drug, these difficulties disappear. Sometimes you have to try several different medicines, before you can choose, which is characterized by the greatest efficiency in a particular case.

pharmachologic effect

The result of the effect of the substance is to reduce the amount of glucose in the body. This is achieved due to its compounds with cell membrane receptors, during which an insulin-selector complex is formed.

Such complexes contribute to the active flow of intracellular processes and the synthesis of enzymes. The amount of sugar is reduced due to a faster pace of its movement between the cells.

This ensures his absorption with muscle tissue and organs. In this case, insulin slows down the production of glucose in the liver. Also under its influence, protein production increases, glycogenogenesis and lipogenesis processes are activated.

The duration of the medication depends on how quickly the active substance is absorbed. This affects the dosage of the drug, the method of administration and place of the injection. Because of this, the profile of the influence of the medication is distinguished by instability. Efficiency indicators may differ not only from different people, but also in one patient. In most cases, the drug begins to act 1.5 hours after injection. The peak of efficiency is observed within 4-12 hours. The medicine continues to influence the patient about a day.

The beginning of its impact and the activity of the assimilation is also due to the dose, concentration active substance and a place of injection. The distribution occurs unevenly. The substance does not have the ability to penetrate the placenta barrier, as well as in breast milk. The destruction of isophanes occurs in the kidneys and the liver, the extension of its greater part is carried out by the kidneys.

Instructions for use

One of the main aspects of the success in treatment is compliance with the instructions for the use of drugs. Their violation leads to adverse consequences in the form of complications. That is why it is not allowed to independently make changes to the doctor appointed by the doctor.

Insulin Isophane is intended exclusively for subcutaneous injections (in rare cases, intramuscular administration is used). It is advisable to make them before breakfast. The frequency of injections is 1-2 times a day, and the time of their execution should be the same.

Doses of drugs are selected in accordance with the level of glucose. In addition, it is necessary to take into account the age of the patient, the degree of sensitivity to insulin and other features. This means that adjusting the graph of injection without orders of the attending physician is unacceptable.

An important nuance of using the drug is the choice of place for injections. They should not be done on the same body of the body, as this may cause violations in the assimilation of active substances. Injected in the shoulder, femoral and buttock zones are allowed. You can also enter the medicine into the front abdominal wall.

Video lesson on insulin introduction using a syringe knob:

Side reactions and overdose

The occurrence of side effects from insulin isofane is a rare phenomenon, if follow the rules. But even with their observance, it is impossible to exclude the likelihood of advent of negative reactions.

Most often arise:

In case of overdose, the patient may dramatically decrease the amount of blood sugar, which is due to hypoglycemia. Methods for the relief of this state depend on the degree of gravity. Sometimes hospitalization and treatment can be required with medicines.

Insulin Isofanes need to combine with others medicinal preparations. Since diabetes is often complicated by other diseases, it is necessary to use different means.

But not all of them are combined with each other. Some drugs are able to strengthen each other's action, which leads to overdose and side effects.

In relation to Isophane, the means are:

• inhibitors of Mao and APE;
• beta adrenoblocators;
• tetracyclines;
• anabolic steroid;
• means with hypoglycemic effect;
• alcohol-containing medicines;
• sulfonamides, etc.

Usually doctors try to avoid sharing insulin drugs and listed funds. But if it is impossible, you need to adjust the doses of both.

There are medicines that, on the contrary, reduce the effect of the drug under consideration, making treatment ineffective.

These include:

• diuretics;
• glucocorticoids;
• means of hormonal contraception;
• some types of antidepressants.

If you need to receive them simultaneously with insulin, you need to select a suitable dosage.

Caution must also be observed with respect to salicylate and reserpine, which can provide both reinforcing and weakening effects.

When taking this medication, you need to abandon the frequent use of alcohol. At the beginning of insulin therapy it is worth avoiding the management of the mechanisms, since the patient may violate the attention and reaction rate.

To replace this medicine to another without the knowledge of the doctor should not. If there is an unpleasant feeling, you should report them to a specialist and with it together determine which drug is better to use.

Assigns to control blood sugar and lead workflows in the body. You can use for complete and partial treatment.

Composition and action

Insulin Isofan is human genetically engineering (lat. Insulinum IsoPhanum Humanum Biosyntheticum) Hormon, the action of which is identical to the body identically and refers to medium-long.

The composition of the medication contains in 1 ml of 100 units of the effective ingredient, as well as additional substances, including water for injections, protamine sulfate, sodium dihydrophosphate, phenol crystalline, metaceol and glycerol. Produced in the form of a suspension. Provides such actions:

• enhances lipogenesis and glukegenesis, which reduces blood sugar levels;
• increases the absorption of glucose tissues;
• activates intracellular metabolic processes;
• lowers glycogenize;
• after the introduction begins to act 1-1.5 hours;
• efficiency is maintained for 11-24 hours.

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When are you prescribed?

Indications for application:

The drug is appointed with diabetes in pregnant women.

• diabetes mellitus 1 and 2 types;
• stage when the body has resistance to opposing drugs taken orally;
• diabetes mellitus 2 in pregnant women (in the absence of effect from diets);
• partial resistance to sucroppy drugs in comprehensive therapy;
• complications of the disease;
• surgical interventions (as part of integrated or single treatment).

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Instructions for the use of "Insulin-Isophane"

The medicine is administered subcutaneously, sometimes you can prick intramuscularly. The average dosage per day is 0.5-1 IU / kg. When carrying out manipulations, the drug must be room temperature. The injection is made 1-2 times a day for 30-45 minutes before breakfast 8-24 pieces disposable. The place of procedure is changed each time (thigh, buttock, front abdominal wall). The dosage is selected individually, based on the blood glucose indicators and the urine, as well as the disease.

The instruction recommends that children and adults with increased sensitivity use the daily dose of up to 8 months, and low - it can be above 24 meters. Patients who introduced 100 and more, with the replacement of the hormone, should be hospitalized. If the patient is used by a substitute for a medical preparation, the blood glucose level should be controlled. According to the instructions for the use of intravenous injections, insulin, medium-continuous operation is prohibited.

Contraindications

In addition to useful qualities, the drug has such contraindications:

• increased sensitivity to the components of therapeutic agent;
• reduction of blood sugar and during pregnancy;
• the presence of a pancreatic tumor leading to excessive production of insulin hormone (insulinoma);
• carefully apply patients over 65 years and having problems with liver and kidneys.

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Sideflines

Although "insulin" is an important medical examination for diabetics, it has such side effects:

• allergic rash in the form of urticaria;
• lower pressure;
• temperature increase;
• sweep quinque and anaphylactic shock;
• feeling of cold and shortness of breath;
• hyperglycemia;
• in place of injection swelling and itching;
• violation of visual functions;
• feeling of fear and feelings of hunger, lack of sleep, depressive condition and others.

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Compatibility

There are medical preparations that enhance the properties of "Insulin-Isophane" with joint admission, they include:

• hypoglycemic drugs in tablets;
• monoaminoxidase inhibitors, angiotensin-shift enzyme, NVPS;
• sulfamide;
• separate antibiotics;
• assimilative steroids;
• funds from fungal diseases;
• "Theophyllin" and "clofibrate";
• drugs with lithium.

Reduces the effect of nicotine preparation, alcohol enhances the sugar effect. And also exist drugs that affect the strengthening and decrease in the effectiveness of "insulin-isophane" - these are β-adrenoblays, "reserpine", "pentamidine". The preparations that reduce the action include:

• hormones thyroid gland and adrenal cortex;
• "Heparin";
• diuretic drugs;
• antidepressants;
• "Danazole" and "Morphine";
• oral contraceptive means.

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Symptoms overdose

If overdose happened therapeutic agent, there may be changes in mental statewhich are manifested by fear, depression, irritability, unusual behavior. And also the occurrence of hypoglycemia is a decrease in blood sugar levels. It is treated by administering dextrose or glucagon. In the case of the hypoglycemic coma, the patient is administered to dextrose until the condition stabilizes. Then welcome food with increased content Carbohydrates.

Precautions

Before injection, you need to make sure that the solution is transparent, without clouds. When flakes, muddy, sediment drug is prohibited. If a patient has a cold or other infectious disease, it is recommended to consult a dosage doctor. The temperature of the medication before the enroll should be adjusted to room floor. It is necessary to constantly change the injection injection zone.

Analogs of the drug

The use of substitutes of the drug must be coordinated with the doctor, because hormones are serious drugs that can lead to undesirable reactions. Analogues of Insulin-Isophane have been created, which have the trade name "Insumal", "Humulin", "Biogulin", "Pensulin", "Insulidd", "Sensulin", "Aktrafan", "arise" and others. Preparations to the patient can only be prescribed by the doctor based on the composition, as well as the dosage that is selected individually.

Information is given only for general familiarization and cannot be used for self-medication. Do not deal with self-medication, it can be dangerous. Always consult your doctor. With partial or complete copying of materials from the site, an active reference to it is required.

Insulin Isofane: Instructions for use and price of the drug

Insulin treatment has a substitution, because the main task of therapy is compensation of failures in carbohydrate exchange By introducing a special preparation under the skin. Such a medicine affects the body as well as natural insulin produced by the pancreas. At the same time, treatment is full or partial.

Among the means used in diabetes, one of the best is insulin isofane. The drug contains human genetically engineering insulin of the average duration of action.

The tool is produced by B. various forms. It is introduced in three ways - subcutaneously, intramuscularly and intravenously. This allows the patient to choose the optimal version of the level of glycemia.

Indications for the use and trade names of the drug

The use of the means is shown in the insulin-dependent form of diabetes. Moreover, therapy should be lifelong.

Insulin as Isophane The human genetically engineering drug is appointed in such cases:

1. diabetes 2 Type (insulin-dependent);
2. surgical manipulations;
3. resistance to sugar-imaging agents assigned orally as part of comprehensive treatment;
4. gestational diabetes (in the absence of effectiveness of diet and therapy);
5. interpurrente pathologies.

Pharmaceutical companies produce human genetically engineering insulin under various names. The most popular - engaged-n, biosuline-H, Protafan-nm, Insuran-NPH, general-n.

Other types of isophanes insulin are used with the following trade names:

• Insumal;
• Humulin (NPH);
• Pensulin;
• Isophane Insulin NM (Protafan);
• Akratran;
• Insulidd n;
• Biogulin H;
• PROTAFAN-NM PENIFILL.

It is worth noting that the use of any synonym of Isophane insulin should be coordinated with the doctor.

pharmachologic effect

Human insulin has a hypoglycemic effect. The drug interacts with the receptors of the cytoplasmic cell membrane, forming an insulinseptor complex. It activates the processes occurring inside the cells and synthesizes the main enzymes (glycogenxintytase, piruvatkinase, hexochinase, etc.).

A decrease in sugar concentration is carried out by increasing its intracellular transport, lowering the glycosis rate of the liver, stimulation of suction and further absorption of glucose tissues. Also, human insulin activates protein synthesis, glycogenogenesis, lipogenesis.

The duration of the means depends on the speed of absorption, and it is due to various factors (area of \u200b\u200badministration, method and dose of application). Therefore, the effectiveness of isophane insulin can be flawed both in one patient and in other diabetics.

Often after injection, the effect of drugs is observed after 1.5 hours. The highest performance of efficiency is 4-12 hours after administration. Duration of action - one day.

So, the fullness of the absorption and the beginning of the action means depend on such factors as:

1. region of administration (buttock, thigh, belly);
2. concentration of the active substance;
3. dosage.

Preparations of human insulin are distributed in the tissues unevenly. They do not penetrate the placenta and are not absorbed into breast milk.

Insulinsee is destroyed mainly in the kidneys and liver, withdrawing with the kidneys in the amount of 30-80%.

Methods of application and dosage

Instructions for use to insulin isophane says that it is often administered subcutaneously to 2 times a day before breakfast (Zamin). At the same time, it is necessary to change the area of \u200b\u200bthe injection daily and store the used syringe with room temperatureand new - in the refrigerator.

Sometimes the means is injected intramuscularly. And an intravenous way to use insulin of an average action is practically not applicable.

The dosage is calculated individually for each patient, based on the level of sugar concentration in biological fluids and the specifics of the disease. As a rule, the average daily dosage fluctuates in the range of 8-24 IU.

If patients have hypersensitivity to insulin, then the optimal daily amount of the drug is 8 meters. With poor susceptibility of hormone, the dosage increases - from 24 meters per day.

When the daily volume of the means is greater than 0.6 meters per 1 kg of mass, then 2 injections are made in different parts of the body. Patients daily dose which from 100 me and more, in the event of insulin replacement, should be hospitalized.

Moreover, when translating from one type of means to another, it is necessary to monitor the sugar content.

Side reactions and overdose

The use of human insulin can cause allergic manifestations. Most often is angioedema edema (hypotension, shortness of breath, fever) and urticaria.

Also, the dosage can also lead to hypoglycemia, manifested by the following symptoms:

• insomnia;
• leather pale;
• depression;
• hyperhydrosis;
• fear;
• excited state;
• frequent heartbeat;
• headache;
• confusion of consciousness;
• vestibular disorders;
• hunger;
• tremor and so on.

Even the side effects include diabetic acidosis and hyperglycemia, which manifests the hyperemia of the face, drowsiness, poor appetite and thirst. Most often, such states are developing against the background of infectious diseases and fever, when the injection pass, incorrect dosage and in the event of non-compliance with the power mode.

Sometimes there is a violation of consciousness. In difficult situations, a precomath and comatose state develops.

At the beginning of treatment, transitional failures may occur in the visual function. There is also an increase in the titer of anti-zulin bodies with further progression of glycemia and immunological reactions of cross-character with human insulin.

Often, the place of introduction swells and zudit. At the same time, the subcutaneous fatty tissue is hypertrophy or atrophy. And at the initial stage of therapy, temporary disorders of refraction and swelling may occur.

In case of overdose hormonal drugs The blood sugar level is greatly reduced. This causes hypoglycemia, and sometimes the patient falls into someone.

With a slight output of the dose, highly carbonate food should be accepted (chocolate, white bread, bun, candy) or drink a very sweet drink. In the case of fainting the patient in / in a solution of dextrose (40%) or glucagon (p / k, V / m).

When the patient comes into consciousness, it must be fed by food, abundant carbohydrates.

This is allowed to prevent hypoglycemic recurrence and glycemic to whom.

The suspension for p / to administration is not applied with solutions of other LS. And joint taking with sulfonamides, aPF inhibitors/ Mao / carboangendresses, NSAIDs, ethanol, anabolic steroids, chlorochinine, androgens, quinin, bromocriptine, podoxin, tetracycline, drugs, cloth, phenfloramine, ketonozol, cyclophosvamide, theophylline, furnacesol effect.

The weakening of hypoglycemic action contributes:

1. blockers H1-histamine receptors;
2. Glucagon;
3. Somatopin;
4. Epinephrine;
5. Phenytoin;
6. oral contraceptives;
7. Epinephrine;
8. Estrogens;
9. calcium antagonists.

In addition, the reduction of sugar causes joint use of isophane insulin with loop and thiazide diuretics, clone, BMKK, diazoxide, danasol, thyroid hormones, tricyclic antidepressants, sympathomimetics, heparin and sulfinpyrazone. Also, hypoglycemia enhances Nicotine, marijuana and morphine.

Pentamidin, beta-adrenoblays, octreotide and reserpine can enhance or relax glycemia.

Precautions for the use of Isophane insulin in the fact that a person, with diabetes, must constantly change the places where the insulin injection will be made. After all, it is possible to prevent the appearance of lipodystrophy.

Against the background of insulin therapy, it is necessary to regularly monitor glucose concentration. After all, in addition to joint admission with other drugs, other factors can cause hypoglycemia:

• diabetic diarrhea and vomiting;
• replacement of the drug;
• diseases that reduce the need for hormone (renal and liver failure, pitpofunction of thyroid, pituitary gland and other);
• non-time meal;
• change in the injection area.

Incorrect dosage or large pauses between insulin injections may contribute to the development of hyperglycemia, especially when type 1 diabetes. If the therapy is not adjusted on time, then the patient sometimes develops a ketoacidotic coma.

In addition, the change in the dose is required if the patient is greater than 65, it has the functioning of the thyroid, kidney or liver. It is also necessary for hyponituitarism and Addison's disease.

In addition, patients should know that human insulin preparations reduce alcohol tolerance. At the initial stages of therapy, in case of replacement of funds, stressful states, strong physical Loads Do not drive a car and other complex mechanisms Either to engage in potentially hazardous activities requiring increased concentration and speed of reactions.

Pregnant patients should be borne in mind that in the first trimester the need for insulin decreases, and in 2 and 3 - increases. Also fewer hormone may be needed at generic activity.

About the pharmacological features of Isophane will tell the video in this article.

Insulin-Isofan: Instructions for the use of suspension

Active Substance: Insulin

human genetically engineering isofan

Manufacturer: Novo Nordisk, Denmark

Pharmacy vacation condition: prescription

Storage conditions: T in the range of 2-8 degrees

Human genetically engineered insulin isophane is used for state therapy associated with the insufficiency of the organism of its own hormone using an insular apparatus. There is no drug with such names on sale, as it is a form of a valid substance, but there are analogues. A vivid example of such a substance on sale - Rinsulin.

Indications for use

The main indication is the therapy of the diabetes of the first type, but in some cases it may be written in the presence of an insulin-dependent form of the disease. Any trading name isophane is suitable for human therapy, which is no longer taken by hypoglycemic substances due to complete or partial resistance. Less often, medicine is used in pregnant women with the second type of diabetes.

Composition and form of release

1 ml of solution consists of 100 units of the active active ingredient. Auxiliary components - Protamina sulfate, sterile water for injections, crystalline phenol, sodium dihydrate phosphate, glycerol, metacrezol.

Suspension for injection, transparent. One bottle contains 3 ml of substance. In one package there are 5 cartridges or for sale in one bottle of 10 ml of the drug at once.

Medical properties

Isophane insulin is a secondary duration of the hypoglycemic agent, which was manufactured using recombinant DNA technology. After subcutaneous administration, the endogenous hormone binds to an insulin geceptor complex, as a result of which the synthesis of many enzyme compounds - hexokinase, pyruvatkinase and others occur. Due to the substance administered from the outside, the intracellular glucose space increases, so that it is absorbed by the tissues, and the rate of synthesis of sugar liver is significantly reduced. For frequent use The medication launches lipogenesis, glycogenesis and proteinogenesis.

The duration of action and the rate of occurrence of the effect of different people depends on many factors, in particular from speed exchange processes. What means - this process is individual. On average, since this is a hormone of average speed, the beginning of the effect is developing after an hour and a half from the date of subcutaneous administration. The duration of the effect is a day, peak concentration occurs within 4 - 12 hours.

The tool is absorbed unevenly, excreted mainly through the kidneys, the severity of the effect depends directly from the place of administration (abdomen, arm or thigh). The medication does not penetrate the placental barrier and in breast milk, therefore allowed pregnant and recently born mothers.

Mode of application

The average cost of medication in Russia is 1075 rubles per pack.

Pricking subcutaneously, once a day, in different places. The frequency of injections in one place should not exceed more than 1 time per month, so the location of the medication is changed each time. Before direct use, the ampoule is rolled in the palms. Injection instructions for injections Basic - sterile treatment, the needles are entered subcutaneously at an angle of 45 degrees into a clamping fold, then the place is carefully disinfected. Dosages are selected by the doctor individually.

During pregnancy and breastfeeding

The drug is allowed to use in these periods.

Contraindications and precautions

These include: the intolerance of a specific active substance and low sugar levels at a specific point.

Cross drug interactions

Reduce the effect of the drug: systemic glucocorticoids, oral contraception, estradiol and progesterone, anabolic steroids, diuretics, antidepressants, thyroid hormones.

Enhance efficiency: alcohol, salicylates, sulfonamides and beta blockers, Mao inhibitors.

Side Effects and Overdose

Hypoglycemia or lipodystrophy is possible when not complying with the injection and appointed dosage rules. Less frequent system side effects in the form allergic reactions, shortness of breath, reduction of blood pressure, hyperhydroposis and tachycardia.

When overdose, classical signs are manifested low sugar In the blood: a strong sense of hunger, weakness, loss of consciousness, dizziness, sweating, the desire to eat sweet, in severe cases - a comatose state. Easy signs are stopped by the reception of fast carbohydrates, medium-in-decrement injections or glucose intravenously. Heavy situations require an urgent call to doctors.

Analogs

Rincelin PNH

Herofarm Bio Ltd., Russia

The average cost in Russia is 1000 rubles per pack.

Riosuline is a complete analogue and consists of an insulin of isophane an average duration of action. This medication form is good because it does not require frequent subcutaneous administration.

• Not from the cheapest
• Side effects are possible.

Humulin NPH

Eli Lilly East, Switzerland

The average price in Russia is 17 rubles.

Humulin NPH is an analogue of the average impact speed.

Insulin Isophane - Human hormone made using genetic engineering

In supporting therapy in diabetes, both 1 and 2 degrees, an important role is played by a hormone introduced into the body. New drug Insulin Isophane will help to safely live patients with diabetes. Treatment of diabetes with insulin has substitution.

The purpose of such medication is to fill the loss or oversupply of carbohydrates as part of metabolism using the subcutaneous introduction of a special hormone. This hormone affects the body identically natural insulin, which produces pancreas. Treatment can be partial or complete.

Among the preparations successfully used for the treatment of diabetes mellitus 2 and 1 degree, insulin Isofane has proven well. It includes the human genetic engineering insulin, which has an average duration of action.

This medicine, this hormone, indispensable for the full-fledged life of a person who has problems with sugar in

blood is produced in different forms:

• For leading under the skin;
• For introduction to Vienna;
• For intramuscular administration.

Such a choice gives the opportunity to keep a diabetes of varying degrees to keep the blood sugar level under control by any method of its introduction to the blood, adjusting it when necessary.

Insulin Isofane - Indications for use:

1. Resistance to sucroppural drugs that need to be drunk in the form of tablets within the framework of complex treatment;
2. Diabetes 2 and 1 degree, insulin-dependent;
3. Diabetes gestational, if there is no effect from diets;
4. Intercurrent type pathology.

Isophan: Analogs and other names

Trade names of Isophane insulin may be as follows:

How valid

Insulin Isophane The human genetic engineering influences the body, having hypoglycemic effect. This drug is in contact with the membrane cell cytoplasm receptors. This is how an insulin gelector complex is created. His task is to make an active metabolism, which is carried out inside the cells themselves, as well as assistance in the synthesis of the main of all existing enzymes.

Reducing the amount of blood sugar passes by increasing the transportation of it inside the cell, as well as a reduction in sugar production rate, using the suction process. Another advantage of human insulin is protein synthesis, activation of lithogenesis, glycogenogenesis.

Time, as a long time, this drug is directly proportional to the absorption rate of the drug into blood, and the suction process depends on the method of maintaining and dose of the drug. Therefore, the effect of this drug in different patients is different.

Traditionally, after an injection, the medication begins after 1.5 hours. The peak of efficiency falls at the time 4 hours after the administration of the drug. Duration of action - 24 hours.

Isophane suction intensity depend on the following:

1. Injection place (buttock, belly, thigh);
2. Concentration of active substance;
3. Dose.

This medicine is derived to the kidneys.

How to use: reading to use

According to the instructions for the use of isophane, it is necessary to enter it subcutaneously twice a day: in the morning and in the evening before meal (they will be removed before meals). The injection site must be changed every day, the used syringe should be stored at normal, normal temperature, and the new one is in the package, in the refrigerator. Rarely this drug is introduced into the muscle, and intravenously - almost never, since it is an insulin of an average action.

The dose of this drug is calculated individually for each suffering from diabetes, as part of consultation with the attending physician. Based on the volume of sugar in the plasma and the specifics of diabetes. The average daily dose is traditionally varied within 8-24 IU.

In the case of hypersensitivity to insulin, it is necessary to take no more than 8 months per day if the hormone is perceived poorly, the dose can be increased to 24 and more of me during the day. If the daily dose of the drug should exceed 0. 6 IU per kilogram of the patient's body mass, then at once there are 2 injections in different places.

• Hives;
• Hypotension;
• Temperature increase;
• Chills;
• Dyspnea;
• Hypoglycemia (fear, insomnia, face pallor, depression, over-excitation, sucking feeling of hunger, shaking limbs);
• Diabetic acidosis;
• Hyperglycemia;
• Impairment;
• Edema and itching at the injection site.

Overdose by this preparation is fraught with hypoglycemia and a coma. Dose excess can be neutralized if you take a high carbohydrate food (chocolate, candy, cookies, sweet tea).

In the case of loss of consciousness, enter the patient intravenously a solution of dextrose or glucagon. When consciousness returns, you should give a patient to food, with a high content of carbohydrates. It will give the opportunity to avoid both the glycemic coma and hypoglycemic recurrence.

Insulin Isofane: Is it possible to eat with other medicines

Increases the hypoglycemic effect (bringing the volume of blood sugar to normal) isophane symbiosis with:

1. Sulfonamides;
2. Chlorochinin;
3. ACF / MAO / carboanhydrase inhibitors;
4. Ethanol;
5. Negroesol;
6. Funds belonging to the group by anabolic steroids;
7. Phenfloramine;
8. Tetracycline drug preparations;
9. Clofibrate;
10. Medicines of theophylline group.

The hypoglycemic effect decreases (bringing the amount of blood sugar to normal) due to the symbiosis of isophane with such drugs:

The amount of sugar in the blood is reduced due to symbiosis of isophane insulin with thiazide and loop diuretics, with BMKK, as well as with thyroid hormones, sympathomimetics, clone, danasol, sulfintizon. Morphy, marijuana, alcohol and nicotine also reduce the amount of blood sugar. Drinking and smoking patients with diabetes can not.

In addition to the joint admission of unsuitable drugs with isofan, hypoglycemia can provoke such factors as:

• Transition to another medicine supporting sugar levels normally;
• Vomiting caused by diabetes;
• Diabetes diarrhea;
• Enhance physical. load;
• Diseases that reduce the need for insulin (pituitary gland, thyroid pit hypofunction, liver failure, renal failure);
• When the patient did not sing on time;
• Change point of injection.

Incorrect dose or a large temporary interval between injections can cause hyperglycemia (especially in diabetes 1 degree). If you do not adjust therapy in time, the patient can go to the ketoacidotic to whom.

Consisting of this medicine patient older than sixty years old and the more the one who has broken the work of the thyroid gland, kidneys, liver, it is necessary to consult with the attending physician about the dosage of insulin isofan. The same measures should be taken if the patient suffers from hypocituitarism or Addison's disease.

Insulin Isofane: Cost

The price of Isophane insulin varies from 500 to 1200 rubles per package in which 10 ampoules are included, based on the producer and dosage country.

How to prick: special instructions

Before tying a medicine into a syringe, check that the solution is not dying. It must be transparent. If there are flakes, foreign bodiesThe solution became muddy, a precipitate was formed, it was impossible to use the medicine.

The temperature of the injected drug must be room. If you are currently colder or more than another infectious disease, you must consult with a doctor about a dose. When replacing the drug, it should be done under the supervision of a doctor, we are prudent to go to the hospital.

Pregnancy, lactation and insulin isofane

Pregnant, suffering sugar diabetes, you can take insulin isofan, it will not get to the fetus through the placenta. You can use them and nursing mothers forced to live with this disease. It is important to know that during pregnancy in 1 trimester, the need for insulin decreases, and in the second and third - rises.