Let us analyze the properties of the drug, indications for its purpose, instructions for use, and so on.

Characteristics of the drug

Leukocytic human interferon (international name- interferon alpha) is available in two forms - a solution for inhalation and intranasal use and a dry lyophilized powder (sometimes compressed into tablets). The liquid form has a shade from colorless to light pink, dry - from white to pinkish.

Human leukocytic interferon (Interferon leukocytic human) is a complex of proteins synthesized by leukocytes of donor blood under the influence of the interferon inducer virus. They are purified by ultra- and microfiltration methods.

Analogues of this immunomodulating drug:

The tool can be used in combination with other medicines. The drug is dispensed without a doctor's prescription and is valid for 2 years from the date of manufacture. It must be stored in a cool, dark (2-8 degrees above zero) place protected from light. Keep out of the reach of children!

Average prices for human leukocyte interferon are relatively low. So, in most pharmacies, a pack of 10 ampoules of the drug will cost one ruble.

Composition of the preparation

1 ml of liquid human leukocyte interferon contains:

• Interferon alphaME.
• Sodium chloride - 0.09 mg.
• Sodium dihydrogen phosphate dihydrate - 0.06 mg.
• Sodium hydrogen phosphate dodecahydrate - 0.003 mg.
• Distilled water for injection - about 1 ml.

Pharmacological properties

This immunomodulatory drug belongs to pharmacological group cytokines. Its properties stand out as follows:

• Immunostimulation - makes the immune response stronger.
• Immunomodulation - normalizes the immune status.
• Antibacterial effect - fight against different kind mixed infections.
• Antiviral action - helps the body to resist diseases such as herpes, flu, adenoviral diseases.
• Anti-inflammatory, anti-tumor effect.

Dry and liquid product is non-toxic, sterile, harmless when administered by respiratory tract... In this case, the use of powder for injection is prohibited.

Indications for use

Human leukocyte interferon is used both for the prevention of acute viral infections and for the treatment of early forms of disease with initial symptoms.

Indications can be divided into three main groups:

• Intranasal administration: preventive measures and treatment of ARVI, influenza.
• Parenteral administration: genital warts, hepatitis B and C, non-Hodgkin's lymphoma, malignant melanoma, multiple myeloma, renal carcinoma, Kaposi's sarcoma in AIDS sufferers (not sick at this time acute infections), hairy cell leukemia, fungal mycosis.
• Rectal administration: therapy of chronic and acute viral hepatitis.

Also, the drug will be effective for:

• chronic myeloid leukemia;
• primary and secondary thrombocytosis;
• transitional stage of chronic granulocytic leukemia, myelofibrosis;
• reticulosarcoma;
• multiple sclerosis.

Contraindications

Instructions for the use of human leukocyte interferon indicate the following contraindications to the use of the drug:

• Epilepsy.
• Dysfunction of the central nervous system.
• Dysfunction of the kidneys and liver, hematopoietic system.
• Organic heart disease.
• Chronic hepatitis in individuals whose recent treatment has consisted of immunosuppressants.
• Diseases thyroid gland.
• Chronic hepatitis.
• Cirrhosis of the liver with signs of liver failure.
• Pregnancy and lactation.
• Allergy.
• Increased individual sensitivity to active ingredient- interferon alpha, as well as to all preparations of protein origin, to chicken and eggs.

The drug is dangerous to take in the following cases:

• The expiration date has expired.
• The integrity of the packaging has been compromised.
• There is no marking on the container.

Dosage and administration

Instructions for the use of human leukocyte interferon prescribe:

• Children under 3 years of age should only administer the drug intranasally (spray, instillation).
• Children from 3 years old, adults are additionally allowed to inhale.

Intranasal administration. The ampoule with the medicine is opened immediately before use. Then cooled boiled or sterile distilled water is added to it strictly up to the line of 2 ml on the capsule. The product is gently shaken until completely dissolved.

The drug is instilled into the nose using a syringe without a needle or a medical pipette. Another method is spraying: you can use either a third-party spray bottle or the one that comes with the drug. The nozzle is put on the syringe without a needle, then brought close to the nasal passage or going into it about 0.5 cm. Spraying occurs by pressing the syringe plunger. In this case, the patient should sit with his head thrown up.

• Prevention: applied throughout the risk of infection. Instillation - 5 drops, spraying - 0.25 ml into each nasal passage. The manipulation is carried out up to 2 times per day with an interval of at least 6 hours.
• Treatment: when the first signs of the disease appear. 5 drops or 0.25 mg in each nostril. The procedure is repeated up to 5 times a day with an interval of 1-2 hours.

Human leukocyte interferon is administered to children and adults in the same doses.

Inhalation. Inhaled use is considered to be more effective. For it, you need to purchase an inhaler from any manufacturer. For one procedure, the contents of three capsules are required, which should be dissolved in 10 ml of water heated to 37 degrees. In this way, the drug is administered through the mouth and nose twice a day for 2-3 days.

It is prohibited to inject the product by injection!

Side effects

When using this immunomodulatory drug, the following are possible side effects:

• From the gastrointestinal tract: a change in taste, dry mouth, flatulence, constipation, vomiting, diarrhea, nausea, loss of appetite. In rare cases, liver dysfunction.
• From the side of the central nervous system: ataxia, drowsiness or sleep disturbance, impaired consciousness, depression, nervousness.
• From the heart and blood vessels: arrhythmia, arterial hypotension.
• Dermatological consequences: skin rash, slight alopecia, erythema, dry skin.
• Flu-like syndrome: weakness, fever, myalgia, headache.
• Other: granulocytopenia, feeling of weakness, lethargy, weight loss, visual disturbances, dizziness.

special instructions

The remedy should be used with caution when:

• Recently suffered myocardial infarction.
• Myelodepression, changes in blood clotting.
• Elderly patients who have been diagnosed with side effects from the central nervous system when using high doses of the drug. It may even be worth stopping treatment.
• Patients with hepatitis C should be tested for the level of TSH in the blood before treatment. Only when normal performance interferon therapy can be started. In other cases, thyroid dysfunction is possible.
• Combination with opioid analgesics, hypnotics, sedatives.

Human leukocyte interferon is an effective immunostimulating anti-infective agent. It has a number of features of use and contraindications, therefore, before use, it is necessary to familiarize yourself with the instructions.

Interferon: instructions for use, price and analogues

Interferon is an antiviral and immunomodulatory drug.

The active ingredient of this pharmacological drug is human leukocyte interferon. This is the name of a group of proteins of alpha interferon, which are synthesized by blood leukocytes in the human body.

The drug is well tolerated by the human body and has practically no contraindications. This explains the fact that Interferon is often prescribed to infants.

The manufacturer of Interferon is the Russian pharmaceutical company OJSC "Biomed".

In accordance with the requirements of the instructions for use, the drug must be stored in a dark and dry place at a temperature of 2 to 10 degrees Celsius.

Subject to the storage conditions, the shelf life declared by the manufacturer of Interferon is 2 years from the date of issue indicated on the package.

It is forbidden to use this pharmacological agent for treatment after its expiration date.

Release form and price

Interferon is currently available in two forms:

The dry form of release is a freeze-dried porous powder of pinkish or white color.

Both forms are packed in glass ampoules. One package of medicine contains 10 ampoules.

The concentration of the antiviral drug is 1000 IU.

Interferon is distinguished reasonable prices... Of course, in different pharmacies the cost of this pharmacological agent will distinguish. But in general, we can talk about the availability of this drug for a wide range of consumers.

Currently, the price of Interferon in pharmacies ranges from 70 to 130 rubles.

Indications for use and pharmacological properties

In accordance with the instructions for use, Interferon is prescribed for preventive measures and the treatment of influenza and other acute respiratory viral infections (acute respiratory viral infections).

Moreover, this medicinal product as directed by a doctor, it is used for other diseases of a viral and oncological nature. In such cases, Interferon has proven effectiveness and excellent reviews from the medical community. Such diseases include:

• hepatitis B and C;
• fungal mycosis;
• hairy cell leukemia;
• reticulosarcoma;
• chronic myeloid leukemia;
• kidney cancer;
• multiple myeloma;
• secondary immunodeficiencies.

In addition, this medicine is widely used in the treatment of infectious catarrhal rhinitis (rhinitis). The thing is that, according to statistics, the vast majority of rhinitis has a viral etiology.

A huge plus is the ability to use Interferon to treat children, starting from the first days of their lives.

The drug has wide range antiviral and immunomodulatory action. Its pharmacological action is based on increasing resistance, that is, the body's immunity to the effects of pathogenic viruses.

The use of Interferon for the treatment of severe viral and oncological diseases is carried out under the strict supervision of the attending physician, who prescribes a specific therapeutic and therapeutic course.

As for the treatment of acute respiratory viral diseases and the common cold with Interferon, two simple rules must be remembered:

• it should be used when the first symptoms are detected (flu and rhinitis);
• it is applied intranasally, that is, in the form of drops, it is buried in the nasal passages.

The sooner treatment is started, the higher the chance of preventing the development of the disease.

The medicinal dose of Interferon for children and adults is the same.

In the prevention of ARVI and runny nose, 5 drops of the medicine should be instilled into each nostril twice a day.

The interval between instillations should be at least 6 hours.

The drug should be taken two weeks before the expected start of the SARS and influenza season. In conditions Russian Federation and the CIS countries, this season coincides with the autumn-winter period.

In the treatment of acute respiratory viral infections and rhinitis, 5 drops of the medicine should be instilled into each nostril 5-8 times a day.

The interval between taking drops should be 1-2 hours.

The duration of the therapeutic and therapeutic course is 2-3 days. If after this time the symptoms of the disease (ARVI or runny nose) persist, you should stop taking Interferon and seek further instructions to the attending physician.

Preparation of nose drops

The instruction for Interferon contains detailed description the process of preparing nasal drops.

The ampoule with the medicine must be opened immediately before use.

Dilute the powder with distilled and boiled water to the line corresponding to 2 ml.

When properly prepared, the resulting nasal drops from ARVI and runny nose are a colorless transparent liquid (there may be a barely noticeable yellow or pink tint).

Contraindications, overdose and side effects

Contraindications for the use of Interferon are:

• hypersensitivity and individual intolerance to antibiotics and chicken proteins;
• the presence of cardiovascular diseases;
• the presence of liver cirrhosis;
• the presence of kidney disease;
• the presence of epilepsy.

To date, there have been no cases of overdose with this pharmacological drug.

Interferon intake does not cause side effects in adults and children.

During pregnancy and lactation

Interferon during pregnancy and lactation can be used in accordance with the requirements of the annotation without any restrictions.

Analogs

Currently, such analogues of Interferon are produced:

For more information, read the article "Antiviral nasal drops".

Remember, only a qualified doctor can choose from the given analogs the appropriate drug in each specific case.

Efficiency and feedback

Interferon is a very commonly prescribed and used drug with excellent reviews.

Nevertheless, it should be noted that its effectiveness has been proven in the treatment of severe viral and oncological diseases. In the treatment of acute respiratory viral infections and rhinitis, its effectiveness has not been officially confirmed. This is evidenced by numerous reviews of practicing doctors.

However, there is a large group of experts who recommend using it for ARVI and runny nose.

Dear reader, if you have used Interferon before, please leave a review about it on our website. Your opinion and experience will help many people find a medicine.

It's funny that he is prescribed for any ARI. As if it would help. And for prevention. Although there is definitely no point in drinking it for prevention, the spectrum of action is too narrow. Better honey with milk at night to drink more sense.

Highly effective drug in diseases of viral etiology, in conditions of strict adherence to the dosage and the interval between instillations intronasally.

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Before applying the information obtained, consult your doctor.

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Interferon

Prices in online pharmacies:

Interferon is a drug that enhances the body's immune defenses.

Available in the form of lyophilized powder for injection, liquid solution and rectal suppositories.

Pharmacological action of Interferon

In accordance with the instructions for Interferon, 1 ampoule of dry lyophilized powder contains a mixture different types natural alpha-interferon of human blood leukocytes 1000ME.

The composition of 1 ml of a liquid solution of Interferon Alpha includes a mixture of subtypes of natural alpha-interferon from human donor blood 1000ME.

1 candle of Interferon contains a mixture of various types of natural alpha-interferon of human blood leukocytes 40000 IU.

The instructions for Interferon indicate that the drug is one of the factors produced by the body (protein), which prevents the body from damaging viral infections.

Human interferon is a group of endogenous proteins that are produced by leukocytes of human donor blood under the influence of various viruses.

Interferon Alpha is a highly purified sterile protein, which contains 165 amino acids. The drug is created by genetic engineering by means of recombinant DNA. The drug has an antitumor effect. When using Interferon, fluctuations in the concentration of the active substance of the drug in the blood serum are observed.

This drug has antiviral, immunostimulating and antiproliferative activity.

The antiviral effect is due to an increase in the resistance of body cells free from viral infections to possible influences. By linking with specific receptors located on the cell surface, the active substance of the drug changes the properties of the cell membrane, while stimulating specific enzymes; affects the RNA of the virus, thereby dulling its replication.

The immunostimulating effect of human interferon of all forms of release is due to the stimulation of the activity of NK cells and macrophages, which are involved in the body's immune response to tumor cells.

The drug is excreted from the body through the kidneys.

Interferon is effectively used for children and adults.

Indications for use

Interferon Alpha is prescribed for the treatment of Kaloshi's sarcoma (a disease of the vascular bed of the skin, which is accompanied by neoplasm of blood vessels, their swelling and proliferation) in AIDS patients, as well as for the treatment of leukemic reticuloendotheliosis, kidney cancer and Bladder, melanoma, shingles.

Human interferon is used to treat chronic and acute viral hepatitis (inflammation of the liver tissue caused by a virus). Effectively is the use of Interferon in the form of suppositories as part of the treatment of hemorrhagic fever with renal syndrome.

Local application (in the nose or eyes) of Interferon solution for children and adults is prescribed for the prevention and treatment of influenza, acute respiratory viral infections, conjunctivitis, keratouveitis and keratitis.

Method of administration and dosage

Interferon is used in the form of a solution prepared on the basis of boiled or distilled water room temperature... To do this, pour water into the opened ampoule up to the mark that corresponds to 2 ml. After that, the ampoule must be shaken until the powder is completely dissolved. After dilution, the solution turns red; it should be stored in a cool place for no more than 48 hours. In each nasal entrance, 5 drops of the solution should be injected 2 times a day. The interval between application is at least 6 hours.

The most effective is the inhalation method of using Interferon. To do this, the contents of 3 ampoules should be dissolved in 10 ml of water and heated to a temperature not exceeding 37 degrees. Frequency rate of procedures - 2 times a day. The duration of treatment is 2-3 days.

For the treatment of acute respiratory viral infections, according to the instructions, Interferon must be used when the first signs of the disease appear.

Before starting treatment with Interferon Alpha, the susceptibility of the microflora that caused the disease should be determined. For the treatment of leukemic reticuloendotheliosis, an initial dose of BME is prescribed for daily subcutaneous or intramuscular administration for 4-6 months. The maintenance dose is equal to ME for intramuscular administration 3 times a week. Treatment must be carried out under the supervision of the attending physician.

For the treatment of Kaloshi's sarcoma in AIDS patients, an initial dose of ME is prescribed intramuscularly. The duration of therapy is 2-3 months. A maintenance dose of ME is administered daily 3 times a week.

The course of therapy rectal suppositories Interferon should not exceed 15 days. The dose of the drug is prescribed individually and adjusted by the attending physician.

Side effects of Interferon

During the use of the drug, side effects may occur such as headaches and muscle pains, lethargy, fever, sweating, vomiting, dry mouth, diarrhea, loss of appetite and weight, flatulence, constipation, nausea, heartburn, liver dysfunction, hepatitis.

Active substance, which is part of Interferon of all forms of release, can cause visual disturbances, sleep disturbances, depression, increased peristalsis, itching, skin rash, ischemic retinopathy, dizziness, nervousness, joint pain.

Contraindications for use

Interferon of all forms of release is not prescribed to patients who have:

• Severe heart disease;
• Dysfunctions of the kidneys, liver and central nervous system;
• Epilepsy;
• Cirrhosis of the liver;
• Chronic and autoimmune hepatitis;
• Diseases of the thyroid gland;
• Hypersensitivity to the components of the drug.

Overdose

In case of an overdose of Interferon, the body may experience allergic reactions accompanied by skin rash, hives, itching, flaking of the skin, redness.

Additional Information

With caution, it is necessary to take the drug simultaneously with opioid analgesics, sedatives and hypnotics.

The instructions for Interferon indicate that it is necessary to store the drug in a dark, cool, dry place out of the reach of children. The shelf life of powder for solution preparation is 1 year, liquid solution - 2 years, candles - 2 years.

Dispensed from pharmacies on prescription from your doctor.

Human leukocyte interferon 1000ME No. 10 ampoules

Interferon leukocyte people N10

Human leukocyte interferon liquid 1000IU / ml 5ml No. 1 bottle

Human leukocyte interferon liquid solution 1000 IU / ml 5 ml

Interferon leukocyte liquid 1000 IU / ml 5 ml N1 vial with dropper

Each person at least several times in his life has come across such an unpleasant disease as a runny nose. Most often, a stuffy nose with p.

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Many people are interested in this question. If more recently the bathhouse was considered 100% useful, then recently a number of concerns have appeared, pod.

What we eat every day begins to excite us at the moment when the doctor makes an unexpected diagnosis of "atherosclerosis" or "ischemic pain.

A smear for oncocytology (Pap test, Pap test) is a method of microscopic examination of cells that are taken from the surface of w.

Each person can prevent the penetration and development of various infections, the main thing is to know the main dangers that lie in wait on the site.

When using materials from the site, the active reference is obligatory.

Interferon. Instructions for the drug, application, price, release form

The site provides background information. Adequate diagnosis and treatment of the disease is possible under the supervision of a conscientious doctor.

Definition of the medication

Types of medication, commercial names of analogues, release forms

The mechanism of the therapeutic action of the drug

• antiviral action;
• antitumor effect.

The antiviral effect of interferon lies in its ability to inhibit the process of virus multiplication in the cells of the human body (virus replication). Interferons are cellular regulators of immunity, which are produced when the virus enters the body. Further, by binding to specific receptors (signaling molecules on the cell surface), interferon triggers a number of processes. By acting on a special enzyme, oligoadenylate cyclase, interferon prevents the virus from penetrating into nearby cells, and also inhibits the production and release of viral particles. In fact, these cytokines not only block viral replication, but also inhibit the production of cellular proteins. In addition, interferon is able to affect the genetic material of human cells (DNA), which ultimately also increases the barrier function of cells in relation to viral infection... Interferons also stimulate the release of the immunoproteosome protein and the histocompatibility complex, which leads to the activation of cells of the immune system (T-helpers, macrophages, T-killers). In some cases, in severely damaged cells under the influence of interferon, apoptosis (programmed death of the affected cell) occurs.

For what pathologies is it prescribed?

(a disease caused by the human papillomavirus)

(numerous malignant tumors skin)

(a group of malignant neoplasms that affects the human lymphatic system)

(malignant lymphocyte disease)

(neuroendocrine tumors that most commonly occur in the gastrointestinal tract)

(a tumor that arises from pigment cells)

(presence of atypical cells in the cervix)

(characterized by periodic weakening and intensification of symptoms)

How to use the medication?

• viral hepatitis;
• tumor diseases;
• diseases of the central nervous system.

Viral hepatitis

Tumor diseases

• Non-Hodgkin's lymphoma. Treatment of non-Hodgkin's lymphoma must be done in conjunction with chemotherapy. Typically, interferon is injected subcutaneously at 5 million IU. You need to use the drug 3 times a week (every other day).
• Hairy cell leukemia. Interferon is used one-time at 3 million units every other day (three times a week). The medication can be administered both intramuscularly and subcutaneously. The course of treatment is selected by the attending physician.
• Malignant melanoma. The weekly dosage of interferon is 80-100 million units. It is necessary to use the drug 4 - 5 times a week. The duration of treatment is 30 days, after which they switch to maintenance therapy - 10 million units 3 times a week. The course of treatment with the use of maintenance therapy, on average, is 11 - 12 months.
• Carcinoid tumors. Interferon is injected subcutaneously at 3-9 million units 3 times a week. If there is no effect, they switch to another treatment regimen - 5 million units of interferon daily (35 million IU per week).
• Carcinoid tumors with metastasis. Treatment is carried out daily in the form subcutaneous injection 3-4 million units of interferon. Gradually every two weeks single dose increase to 5, 7, 10 million units. The course of treatment is selected by the doctor.
• Multiple myeloma. 5 million units of interferon subcutaneously three times a week. The duration of treatment can only be selected by the attending physician.
• Renal cell carcinoma. Interferon is taken three times a week, 3-10 million units. The course of treatment is individual.

Diseases of the central nervous system

Possible side effects

• disorders of the digestive tract;
• disorders of the nervous system;
• allergic manifestations;
• disorders of the cardiovascular system;
• disorders of the hematopoietic system;
• disorders of the upper and lower respiratory tract.

Digestive tract disorders

• nausea;
• vomit;
• diarrhea;
• constipation;
• abdominal pain.

It is also often observed and toxic effect interferon on liver tissue. This is manifested by an increase in some indicators biochemical analyzes blood. As a rule, there is an increase in the level of hepatic transaminases (enzymes involved in the transformation of some amino acids).

Nervous system disorders

• depression;
• anxiety;
• headache;
• migraine;
• dizziness;
• insomnia;
• violation of consciousness;
• suicidal thoughts (rare);
• hallucinations (very rare).

Irritation of the nerve cells that make up the vestibular auditory nerve can cause pain in the ears or manifest as tinnitus (tinnitus). In the future, the severity of these symptoms gradually decreases.

Allergic manifestations

• hives;
• erythema;
• Quincke's edema;
• Stevens-Johnson syndrome;
• toxic epidermal necrolysis (Lyell's syndrome).

Hives are the most common form of drug allergy. With urticaria, a rash appears on the skin in the form of flat raised, itchy blisters. These blisters are very similar to the blisters that appear with nettle burns. Hives can appear on almost any part of the skin. Sometimes hives are accompanied by symptoms such as pain in the abdomen, nausea and vomiting.

Disorders of the cardiovascular system

Violations of the hematopoietic system

• anemia;
• thrombocytopenia;
• leukopenia.

Anemia, or anemia, is a pathological condition characterized by a decrease in the number of red blood cells (red blood cells) and hemoglobin (a protein that is involved in the transport of gases). Anemia is characterized by a perversion of taste and smell (change in taste habits, addiction to unpleasant odors), damage to the mucous membrane of the upper part digestive system(mouth, pharynx, esophagus), headache and dizziness. Also, anemia can lead to fainting. Often, against the background of anemia, damage to the skin, nails, and hair occurs.

Upper and lower respiratory tract disorders

• sinusitis;
• pneumonia.

Sinusitis is inflammation of the lining of the paranasal sinuses. Sinusitis can occur against the background of a runny nose or ARVI (flu). This pathology is characterized by symptoms such as heaviness in the paranasal sinus, fever, nasal discharge (thick), painful sensations in the sinus with sharp turns of the head. The maxillary (maxillary) and frontal sinuses are most often involved in the inflammatory process.

The approximate cost of the medication

It should be noted that recombinant interferon beta-1b (artificially created using special biotechnologies) is used to treat relapsing multiple sclerosis, as well as secondary progressive sclerosis. This type of interferon is obtained on the basis of a specific fermentation of bacteria (E. coli is used, which contains the human gene responsible for the synthesis of interferon betaser17). The technology for producing interferon beta-1b is quite expensive, and therefore the price for it differs significantly from other types of interferon. Recombinant interferon beta-1b can be found in pharmacies at a price of 6,200 rubles to rubles (depending on the number of ampoules in the package).

Every family medicine cabinet, especially if there are small children, should contain interferon and detailed instructions on its use. This medicine is an ambulance for the occurrence of diseases or for their prevention. In addition to being able to shorten the time of illness, he also prevents it if there is contact with a sick person.

Interferon stimulates the protective functions of the body of children during infectious diseases. If all the recommendations are taken into account, which includes the instructions for this drug, then it is allowed and safe even for babies.

The medicine has an effective effect during the onset of the disease, its complications and for prevention. It does not fight viruses directly, but warns the cells of the body about danger and activates them to fight it.

The following functions of interferon are distinguished:

1. Anti-inflammatory. Can handle hidden inflammatory processes in the body, which lead to various symptoms.
2. Antiviral. A universal remedy against viruses such as adenoviruses, herpes and influenza.
3. Immunomodulatory. Normalizes natural human immunity.
4. Immunostimulating. Helps raise antibodies that fight infections.
5. Antineoplastic.
6. Bacteriostatic. Contributes to the death of mixed infections.

While taking the drug with colds in children, an even greater increase in temperature and the appearance of chills can be observed. This is a normal reaction, as the body has begun to fight harder against pathogenic microbes.

The solution for inhalation and ointment should be stored in a cool dry place. Candles and liquid solution are stored for 2 years, dry solution - 1 year.

Any dosage form (ointment, solution for inhalation, suppositories) is used as directed by a doctor.

Areas of use

The drug is effective against many viruses and bacteria, from which the scope of its application is huge (ophthalmology, gastroenterology, gynecology, pediatrics).

Only a doctor will select the most appropriate dosage and form of drug release.

Characteristics of the main forms of the drug

Children's health in modern world under threat - poor environmental conditions, hereditary factors, unhealthy diet. Children are more likely to get colds and viral diseases. Human body itself produces interferon (a protein that protects the body from infections). But during the period of epidemics or acute illness, they become insufficient, so various dosage forms based on interferon come to the rescue.

Children's interferon has the following forms of release: ointment, drops, suppositories, the medicine is released in ampoules, and a solution for inhalation is also used.

To each dosage form an instruction is attached, which describes in detail in what dosage and how long to take the drug. It is approved for use even for newborn babies.

Nasal drops

The medicine in ampoules is intended for the treatment and prevention viral diseases... It is necessary to bury it in the nose.

Before instillation into the nose, the solution should be diluted with water to the mark that is on all ampoules (equal to 2 ml). If the droplets have been diluted correctly, the resulting liquid will be clear or slightly yellow.

Drops for children in preventive purposes used in the nose twice a day, after 6 hours, 5 drops. The duration of the course depends on the general situation in the area where the child lives. For the treatment of the disease in the acute period, it is supposed to instill 5 drops every two hours, no more than three days.

You can not take the medicine with other drops and if you have allergies. Drops are used exclusively in the nose.

Getting into the stomach and interacting with gastric juice, the drug stops acting due to decay. The drops begin to act immediately, but the visible result in children will be noticeable after two days of use.

Babies should apply 2-3 drops of the medicine to a cotton swab and place in the nasal passage for a few minutes. The nose should be pre-cleaned and rinsed with salt water.

Inhalation

The effectiveness of inhalation with interferon is much higher than all other forms. For one inhalation, three ampoules are required, the contents of which are dissolved in water (10 ml).

Inhalation is possible through the nose or mouth twice a day. Better to use modern nebulizers.

If the nose is swollen and a runny nose is present, a vasoconstrictor should be instilled. After such a procedure, the benefits of inhalation will be greater.

Candles

Interferon in candles can be given even to babies. Enter rectally, one suppository twice a day (morning and evening), for 5 days.

Candles are non-allergenic and side effects on the part of the digestive organs, they are immediately absorbed into the bloodstream, so their effect is noticeable quickly.

Various dosages are available for different ages of children. In rare cases, local irritation may occur. If after five days there is no improvement in the condition, then after a few days the course can be repeated.

Ointment

Interferon ointment is indispensable in conditions when the child needs to be protected from the effects of viruses and bacteria.

The ointment is applied to the nose, twice a day (after 12 hours). It is advisable to apply it in the morning after waking up and in the evening before going to bed. The course of treatment can be up to two weeks. Usually during this period there is a complete recovery of children.

Also, the ointment is used as a preventive measure. During the month, three times a week, babies are smeared with nasal passages.

In addition, the ointment can be used for inflammatory formations. oral cavity(tonsils, stomatitis).

Side effects

The instruction of the medicinal product warns of possible side signs that may appear, but in very rare cases:

Side effects can occur during drug overdose. In this case, you need to seek help from a doctor.

Contraindications

Interferon is a safe and effective medication provided the instructions for use are followed. It should be used with caution in the following diseases:

Interferon is a drug that has a direct effect on immune system organism. It has a pronounced antiviral, antiproliferative and antitumor effect.

Release form and composition

The active ingredient of the drug Interferon is a specific protein synthesized by human leukocytes.

The medicine is available in the following forms:

• Freeze-dried powder;
• Solution for topical use;
• Injection;
• Rectal suppositories.

Indications for use

According to the instructions attached to Interferon, indications for its use depend on the form of release of the drug.

Injection:

• Hepatitis B and C;
• Genital warts;
• Leukemia, hairy cell leukemia - tricholeukemia;
• Tick-borne encephalitis;
• Condition after surgical treatment respiratory papillomatosis of the larynx;
• Multiple myeloma;
• T-cell lymphoma - fungal mycosis;
• Non-Hodgkin lymphomas;
• Chronic myeloid leukemia;
• Reticulosarcoma;
• Kaposi's sarcoma in patients with acquired immunodeficiency syndrome;
• Malignant melanoma;
• Thrombocytosis - primary (essential) and secondary;
• Chronic granulocytic leukemia and myelofibrosis are transitional forms.

Interferon in the form of suppositories:

• Hemorrhagic fever with renal syndrome;
• Viral hepatitis;
• Secondary immunodeficiency conditions.

Lyophilized powder and topical solution:

• Prevention and treatment of influenza, ARVI;
• Diseases of the eyes of viral etiology.

Contraindications

The use of Interferon is contraindicated in the following diseases and conditions:

• Hypersensitivity;
• Chronic heart failure;
• Acute myocardial infarction - acute period;
• Autoimmune diseases;
• Diabetes mellitus - severe forms;
• Lung disease;
• Hepatic or renal failure;
• Chicken pox;
• Cirrhosis of the liver;
• Diseases of the thyroid gland;
• Severe mental disorders, epilepsy;
• Lactation period.

The use of Interferon requires caution in postinfarction cardiosclerosis, arrhythmias, herpes simplex, disorders of bone marrow hematopoiesis, as well as during pregnancy.

Method of administration and dosage

According to the instructions, Interferon in injection solution should be used parenterally - subcutaneously, intramuscularly or intravenously. The dosage depends on the nature of the disease and the age of the patient.

Interferon in the form of a powder and a solution for topical application is used intranasally and conjunctivally. The drug is administered by inhalation using an inhaler of any system or by instillation aqueous solution- before use, the powder is diluted in 2 ml of distilled or cooled boiled water.

In order to prevent influenza and ARVI, the medicine is instilled in 5 drops into each nasal passage twice a day with an interval of 6 hours.

For the purpose of treatment, the drug Interferon should be used on early stage diseases when the first symptoms of malaise appear, 5 drops after 1-2 hours at least 5 times a day for 2-3 days.

In ophthalmic practice in the acute period of the disease, the drug is administered 2-3 drops into each eye from 3 to 10 times a day. When the condition improves - up to 5-6 times during the day. The course of treatment is no more than 14 days.

Interferon in the form of suppositories is used rectally for hemorrhagic fever, acute hepatitis B in children, and secondary immunodeficiency states. The dosage is determined individually, the duration of treatment is no more than 14 days.

Side effects

The use of Interferon, especially when administered parenterally, may cause the following side effects:

• Flu-like syndrome - headache, myalgia, fever, chills;
• Decreased appetite, impaired stool, nausea, vomiting, dryness of the oral mucosa, heartburn, liver failure;
• Anemia, a decrease in the number of leukocytes and platelets in the blood;
• Pressure fluctuations, pain in chest, arrhythmias;
• Dizziness, decreased cognitive function and concentration, sleep disturbance, drowsiness, numbness of the limbs or face, confusion, paresthesia, calf muscle cramps;
• Blurred vision, ischemic retinopathy;
• Dry skin, rash, itching, hair loss, hyperhidrosis;
• Disruption of the thyroid gland.

special instructions

During treatment antiviral drug Interferon should be monitored for blood counts and liver function. With severe thrombocytopenia, the drug should be administered subcutaneously.

In the event of side effects from the central nervous system in patients receiving high doses of the drug, additional examination is required, if necessary, the drug should be canceled.

To reduce the severity of influenza-like syndrome, parallel administration of paracetamol is indicated.

At the initial stage of treatment with Interferon, it is necessary to carry out hydration therapy.

In patients with hepatitis C antiviral agent can cause dysfunction of the thyroid gland, therefore, its use should be started only when normal level hormones.

During the period of use of the drug Interferon, care must be taken when administering vehicles and other moving mechanisms.

Analogs

Interferon synonyms include drugs Alfaferon, Diaferon, Interlok, Inferon, Leukinferon, Lokferon.

Similar pharmacological action have such medicines, how:

• Avonex;
• Altevir;
• Betaferon;
• Viferon;
• Genfaxon;
• Genferon;
• Ingaron;
• Layfferon;
• Reaferon;
• Extavia;
• Rebif;
• Ronbetal and others.

Terms and conditions of storage

According to the instructions attached to Interferon, the drug should be stored in a dry place at a temperature of 2-8 ° C.

Expiration date - 1 year.

Formula, chemical name: is a mixture of various subtypes of natural alpha interferon from human blood leukocytes with molecular weight about 20 kDa.
Pharmacological group: interferons; antiviral (with the exception of HIV) drugs.
Pharmachologic effect: immunomodulatory, antiviral, antiproliferative, antitumor.

Pharmacological properties

Interferon alpha prevents the infection of cells with viruses, changes the properties of the cell membrane, prevents the penetration and adhesion of the virus into the cell. It initiates the formation of some specific enzymes, disrupts the synthesis of RNA of the virus and virus proteins inside the cell. Changes the cytoskeleton of the cell membrane, metabolism, preventing the proliferation of tumor cells. It has a modulating effect on the formation of some oncogenes, which leads to inhibition of tumor growth and normalization of neoplastic cell transformation. Interferon alpha has a stimulating effect on the process of antigen presentation to immunocompetent cells, modulating the activity of killer cells, which are involved in immunity against viruses. When administered intramuscularly, the rate of absorption from the injection site is uneven. In plasma, the maximum concentration is reached after 4–8 hours. 70% of the administered dose is distributed in the systemic circulation. The half-life is 4-12 hours. It is mainly excreted by the kidneys.

Indications

Hairy cell leukemia; viral hepatitis B or C; multiple myeloma; secondary and primary thrombocytosis; kidney cancer; chronic myeloid leukemia; transitional form of myelofibrosis and chronic granulocytic leukemia; Kaposi's sarcoma, which is associated with AIDS; fungal mycosis; multiple sclerosis; reticulosarcoma; therapy and prevention of acute respiratory viral infection (ARVI) and influenza.

Method of administration of interferon alpha and doses

Interferon alpha is administered intramuscularly, intranasally, subcutaneously. Dosages, duration of therapy and frequency of administration are set depending on the indications, form and severity of the disease, the patient's individual response, and the route of administration.
If you miss the next intake of interferon alpha, you must urgently consult your doctor.
Use with caution in patients with a history of recent myocardial infarction, as well as with myelodepression and changes in blood clotting. In case of thrombocytopenia with a platelet count of less than 50,000 / μl, it is necessary to apply the drug subcutaneously. If side effects from the central nervous system appear in elderly patients who receive interferon alfa in high doses, it is necessary to carefully examine the patient, and, if necessary, discontinue therapy. Patients taking interferon alfa require hydration therapy, especially during the initial period of therapy. In patients with hepatitis C who receive interferon alfa, thyroid disorders in the form of hyper- or hypothyroidism are possible. Therefore, prior to treatment, it is necessary to determine the serum TSH level and start therapy only when the TSH levels in the blood are normal. Use interferon alfa with caution with drugs that affect the central nervous system (hypnotics, sedatives, opioid analgesics, etc.) and with immunosuppressants. During the entire course of treatment, it is necessary to control the content of blood corpuscles and liver function. To soften side effects(in the form of flu-like symptoms), the simultaneous administration of paracetamol is recommended.

Contraindications for use

Hypersensitivity, acute myocardial infarction and other severe heart disease, severe disorders of the kidneys, liver or hematopoietic system, chronic hepatitis with decompensated liver cirrhosis, epilepsy and / or other disorders of the central nervous system, chronic hepatitis in patients who are receiving or have recently received treatment with immunosuppressants (except for short-term pretreatment with steroids).

Restrictions on use

Pregnancy, breastfeeding, childhood.

Application during pregnancy and lactation

It is possible to use interferon alfa during pregnancy only in cases where the potential benefit to the mother is higher than the potential risk to the fetus. If it is necessary to use interferon alfa when breastfeeding, then it is necessary to decide on the termination of breastfeeding.

Side effects of interferon alpha

Lethargy, chills, fever, loss of appetite, headache, muscle pain, joint pain, nausea, sweating, vomiting, dry mouth, change in taste, weight loss, abdominal pain, diarrhea, constipation, increased peristalsis, flatulence, heartburn, hepatitis, impaired liver function, dizziness, ischemic retinopathy, visual disturbances, depression, sleep disturbances, impaired consciousness, drowsiness, nervousness, allergic skin reactions (itching, rash).

Interaction of interferon alpha with other substances

Interferon alpha disrupts the metabolism of phenytoin, cimetidine, warfarin, diazepam, theophylline, propranolol, therefore, the toxic effects of these drugs may increase.