Sartans are customary to call special means, the action of which is directed to the receptor blockers to angiotensin II. Often the doctors prescribe them to patients suffering from hypertension, since using medication data it is possible to improve the state of pathology.

Principle of impact

During the process of reducing pressure in the kidneys, the deficiency of oxygen is formed, as a result of which Renin is produced. It is with its help that an angiotensin I appears, which is converted to angiotensin II. This substance is considered to be active componentwhich has an impact on pressure, increasing it. Therefore, the reception of sartans in the presence of the patient helps to influence the receptors, which prevents from hypertension.

Benefits

It is believed that the most effective medicines from hypertension are sardans, they differ next to the advantages:

• the dependence on long-term reception does not appear;
• with normal pressure indicators, drugs do not reduce it;
• well tolerated and have a minimum of negative consequences.

Also, the preparations improve renal functioning in diabetic nephropathy, guarantee the regression of the hearty hypertrophy and lead in terms of heart failure to normal.

To achieve maximum efficiency, scientists are recommended simultaneously with angiotensin II use diuretics. For example, "Indapamide" and "dichlotiazide". Experts note if adhere to this rule, it is possible to increase performance by 1.5 times. Thanks to what is not only increased effect, but also the work of drugs is extended.

Additional impact of medication data:

1. Protection of cells is ensured nervous system. The medicine minimizes the adverse effect of the disease on the brain, being preventive tool from stroke. Since they affect the brain, often doctors prescribe them to patients who have normal pressure indicators, but there is a risk of vascular defeat.
2. The threat of paroxism of atrial fibrillation is reduced, which is ensured by the help of antiarrhythmic effects.
3. The risk of diabetes is reduced. For this, the metabolic effect corresponds to this, and in the presence of this disease, the patient's condition will be coming back, as the insulin resistance of the tissues is carried out.

Important! Such substances during hypertension normalize lipid metabolism, reduce cholesterol content, as well as triglycerides, uric acid volume. All this is very important when receiving diuretics.

Some sartans are beneficial for marfan syndrome, they strengthen the vessels and have prevention of their possible rupture. Also normalizes muscle state. Such an impact has "Lozartan".

Indications

Medical experts appoint Sartan to people who have such problems:

1. which is the main indicator to use them.
2. Heart failure, which can develop against the backdrop of the superchactive renin-angiotensin-aldosterone system. On the early stage Allows you to normalize the heart function.
3. Nephropathy - dangerous consequence diabetes arterial hypertension. For the disease there is a decrease in the number of proteins allocated with urine. Medicines contribute to the slowdown in the development of renal failure.

Such drugs do not affect the metabolism, the permeability of the bronchi, the organs of vision. In rare cases, it can cause a dry cough, an increase in potassium level. The effect of the use of medicines will be visible in a month.

Features

Independent treatment with sartans is prohibited, the therapy scheme must be selected individually for each patient. Before appointment of drugs, special diagnosis is carried out, and the patient's condition features are being studied.

Important! Preparations need to be used every day, without a break.

Often the doctors discharge a combination of funds from Sartan and Diuretics. The most famous preparations for the treatment of hypertension are:

These substances are also responsible for protecting the internal organs, they are safe, since they do not have side effects.

Classification of drugs

The cost of drugs depends on the manufacturer company, the duration of action. Using the cheapest drugs, the patient must understand that they are required to drink more often, as they differ in short exposure.

Preparations are divided according to the composition and exposure. Doctors divide them on prodrugs and active substances, based on the availability of active metabolite. By chemical composition Sartans are:

Without a recipe, all these funds can be purchased in specialized items. In addition, the pharmacies offer ready-made combinations.

Influence on organs

When using sartans, the patient does not have an increase in the number of heart cuts, which makes it possible to prevent the formation of vascular and cardiac hypertrophy. This is very important moment Cordiosclerosis, as well as when there is a cardiomyopathy hypertensive.

As for the effect on the kidneys, since the disease is striking this body, the reception of Sartan can help in this. This is carried out by influence on protein allocations in the urine, namely the medicine helps to minimize the level of these substances. But you should know that the drugs usually increase the plasma creatine, which leads to acute form Diseases.

Contraindications

Sartans in arterial hypertension most often do not cause a side reaction, but sometimes patients may mark such problems:

• dizziness;
• the appearance of sudden pain in the head area;
• a dream is disturbed;
• the temperature increases;
• nausea, accompanied by vomiting;
• constipation or diarrhea;
• it gets itching.

Therapy should be only under the supervision of the attending physician. Forbidden reception medicinal preparations During the rigging of the child and breastfeeding, you can not give them to children. With great care, medications are used with patients suffering from, as well as elderly people.

The doctor selects the patient a dosage individually, which guaranteed quickly leads to a good result, which is preserved for a long time.

Scientists conducted a large number of experiments to prove the effectiveness of funds. People who agreed to take part in the experiments helped learn in practice all the mechanisms of work of Sartan.

Today, there is a study that will check whether the medicines can cause cancer. These are the necessary procedures, as some experts express an opinion on the involvement of Sartan to provoking various tumors. They explain this to the fact that funds falling into the body cause a certain process of certain substances, which, in turn, plays an important role in regulating proliferation cells, which leads to a terrible fear.

Previously, the experiments have shown that people who are forced to use sartans have a great risk of tumor. Despite this, the risk of death from oncology is also in a person who takes the drug, and in the one who even never heard about him.

Modern medicine has not yet definitely answer this question. The reason for this is inhanging full information On the involvement of various medical drugs to the disease. Despite this funds are considered the best in the fight against hypertension.

From this article you will learn: what medications from hypertension belong to the last generation, and are they really better than earlier antihypertensive agents.

Publication date Articles: 07/14/2017

Date of update of Article: 02.06.2019

The concept of "last generation" of antihypertensive drugs does not have an accurate definition or annual release. Most often, this term is used for promotional purposes, promoting a certain drug - not necessarily the most efficient or new ones on the pharmaceutical market. But medical science does not stand still. The tests of new drugs from hypertension are constantly carried out, but their introduction to clinical practice is not one year. Not every new tool demonstrates higher efficiency and safety, compared with older, but also better than those experienced means. Almost every year, new tablets from hypertension are withdrawn to the pharmacological market, which have long known active substances or a combination thereof.

It is still worth it to note that some antihypertensive drugs really have generations, in such cases it is possible to talk about the latest generation of medicines from high pressure.

Most of the representatives from the list of drugs from the hypertension of the new generation are produced in the form of tablets for oral application. The exception is the labetalol - beta blocker, available as a solution for intravenous administration. There are other drugs for parenteral use (for example, nitrates, benzohexonium, nitroprusside sodium), but they are difficult to attribute to new medicines. Almost always intravenous administration of antihypertensive agents is used to treat.

In any case, before applying new products in the treatment of hypertension, you must consult with a cardiologist. You can also independently search for information about the scientific research and safety research. this drug Compared with already well-studied means.

Inhibitors of angiotensin glossy enzyme

Inhibitors of angiotensin glider enzyme (abbreviated IAPF) - this pharmaceutical preparationswhich are used mainly to treat high blood pressure and heart failure. This group of drugs suppresses the activity of an angiotensin gluttering enzyme, which converts inactive angiotensin 1 to active angiotensin 2, due to which the blood vessels expands and reduces the load on the heart.

The first preparation of the IAPF (captopril) was opened more than 40 years ago, from that time clinical practice, 12 drugs from this group were introduced.

Currently, the EAPF is most often used, which were invented back in the 1990s. Their list:

1. Ramipril.
2. Perindopril.
3. Zofenopril.
4. Quinapril.
5. Fozinopil.

Despite the long-time introduction into clinical practice, these drugs continue to be confidently leading among all IAPFs, proving their high efficiency and safety in many studies. Moreover, many scientific evidence suggests that there are almost no significant differences in the effectiveness and safety of various representatives of the IAPF. Effectively reduce blood pressure, both leased and fosinopril, although the value of these drugs in the pharmacy may vary at times.

In addition to the treatment of arterial hypertension, the IAPF is used at:

• Cardiac insufficiency - these drugs reduce the load on the heart.
• Diabetic nephropathy - IAPF help support functional state kidney.
• Chronic kidney diseases - IAPF can help slow down the progression of these diseases.
• Myocardial infarction.

People who should not be taken by IAPF:

• Pregnant and breastfeeding women.
• Patients with increased sensitivity to these drugs.
• Patients with certain kidney diseases - for example, renal artery stenosis.

The most frequent side effect of all - even the newest - IAPF is a dry cough, developing about 10% of people taking these drugs. Less often meet swelling on her lips, language or around the eyes, as well as the deterioration of kidney functions.

Calcium channel blockers

(Abbreviated BKK), sometimes called calcium antagonists, is a group of drugs that affect calcium ions inwards in certain muscle cells. They are used to treat various diseases, including arterial hypertension, angina, Reino and violation syndrome heart Rhythm, as well as to stop premature birth during pregnancy.

List of three main BKK groups:

1. Group of nifedipine (dihydropyridine).
2. Group of diltiazem (benzothiazepines).
3. Verapamil group (phenylalkylamines).

Digidropyridines, which have been developed in the 1960s, are most often used to reduce hell, which were developed in the 1960s.

There are 4 generations of drugs from the Nifedipine group:

• 1 generation - nifedipine;
• 2 generation - Nagardipine, Felodipine;
• 3 generation - amlodipine;
• 4 generation - cylnidipine.

IN clinical practice The most often used preparations of the first three generations, cylnidype doctors prescribed quite rarely.

Amlodipine is perhaps the most commonly prescribed drug from the BKK group. It began to be used in 1990. Amlodipine has demonstrated high efficiency in the treatment of arterial hypertension, as well as safety.

Tsylnidipine is new drug 4th generation from the BCC Group, which has certain advantages over other calcium antagonists. Compared with the representatives of the first three generations, which affect only the L-type of calcium channels, cylnidipine can also block their N-type. This property may have a useful clinical significance that manifests itself with the suppression of reflex tachycardia and a decrease in edema, which is sometimes observed when applying amlodipine and other, older, BKK. Cylnidipine has high lipophilicity, thereby having a prolonged action. Cylnidipine is produced under trade names "Duokard", "Cilacar", "Atellek".

Contraindications for the purpose of dihydropyridines include allergic reactions to a specific drug.

Also calcium antagonists need to be used with caution in the following situations	Possible side effects of the BCC from the dihydropyridine group include
Myocardial infarction and unstable angina	Edems on the legs
Arterial hypotension	Fatigue
Aortic Stenosis Click on photo to enlarge	Nausea
Pregnancy and breastfeeding	Dizziness
Renal and liver failure	Heart palpitations
Heavy heart failure	Tides (feeling of heat spreading throughout the body, especially in the field of face and neck)

Beta blockers

Beta blockers (BB) is a class of drugs that block endogenous catecholar receptors (norepinephrine and adrenaline), due to which they are used to reduce blood pressure, treatment of heart rate disorders, secondary myocardium.

The first BB (propranolol) was synthesized in 1964. Many doctors and scientists agree that the discovery of this group of drugs is one of the most important events in clinical medicine and pharmacologyXX century.

Since that time, quite a lot of BB has been developed. Some of them act on all types of beta-adrenoreceptors, others - only one of them. It is on these properties that three generations of BB are distinguished:

1. 1 generation - propranolol, thymolol, sotalol (non-selective, block beta-1 and beta-2 adrenoreceptors)
2. 2 generation - metoprolol, bisoprolol, esmolol (selective, blocked only beta-1 adrenoreceptors)
3. 3 generation - carvedilol, nebivolol, labetalol (possess additional vasodilatory properties).

Carvedilol is one of the third generation BB, which has an additional property of extension of vessels. It acts on beta-1 and beta-2-adrenoreceptors, and also blocks alpha adrenoreceptors in vessels. Thanks to these effects, Carvedilol reduces harder arterial pressure, less affects the heart rate, does not increase the levels of lipids and glucose in the blood. The disadvantage of the drug is its effect on beta-2-adrenoreceptors, which increases the risk of bronchial spasms. Karreedilol must be taken twice a day, which is not very convenient for the patient.

Nebivolol is a drug that selectively acting on beta-1-adrenoreceptors, which additionally has vascular properties due to increased nitrogen oxide synthesis (NO) in the endothelium of vessels. Thanks to these effects, nebivolol better reduces blood pressure, less influences the heart rate, does not increase the levels of lipids and glucose in the blood, does not cause erectile dysfunction. The negative property of this drug is a rather weak effect on beta-blockers, so it is most often used in older people with heart failure.

LaBetalol is a drug with non-selective beta blocking properties and affecting alpha receptors. Labetalol is used primarily in the form of intravenous administration at which it has a very short time of action, which allows you to achieve good control over the effects of the drug. This is the most effective beta blocker for the treatment of hypertensive crises. It is often used at a peochromocytoma (tumor of adrenal glands) and preeclampsia (late toxicosis in pregnant women).

List of common for beta blockers side Effects:

Angiotensin receptor blockers 2

Angiotensin receptor blockers 2 (s), or sardans - the newest group of medicines widely used to treat arterial hypertension. The first Sartan (Losartan) was introduced into practice in 1986.

The action of sartans is based on the blockade of the latter level of the renin-angiotensin system, that is, to prevent the binding of angiotensin 2 with its receptors. Thanks to these effects, the sconium causes the extension of vessels, reduce the secretion of vasopressin and aldosterone (hormones that contribute to the fluid and sodium delay in the body), which leads to a decrease in blood pressure.

The most recent walls admitted to clinical application, Olmesartan (Cardosal), Fimasartan (Canarb) and Azilsartan (Earbie).

Indications for the use of sartans, including the newest drugs:

• Arterial hypertension.
• Heart failure.
• Pathology kidneynce sugar diabetes.
• Chronic kidney disease.

As can be seen, the testimony for the use of sartans is practically the same as for the use of another group of drugs affecting the renin angiotensin system - IAPF. In most cases, si are prescribed in those situations when the reception of the IAPP led to the appearance of side effects (dry cough). It should be borne in mind that older IAPPs have almost the same efficacy in reducing blood pressure, they cost less and have certain advantages over sartans in the treatment of patients with diabetes.

The reception of Sartan is usually well tolerated by most patients.

Renin direct inhibitors (Alisian)

Alisian is a medicine from the hypertension of a new generation, which has not yet acquired great prevalence. The only drug of this class is Alisian, who received permission for clinical use in 2007.

Alisianin binds to renin, suppressing its interaction with angiotensinogen, due to which the formation of angiotensin 1 and angiotensin 2 is prevented.

Alisianwood is used only for the treatment of arterial hypertension, and in this case, it is not recommended to use it as the first line of therapy.

Sartans were subsequently an in-depth study of the pathogenesis of diseases of the cardiovascular system. This is a promising group of drugs that already occupy the leading position in cardiology.

Sartans are considered inexpensive medicines that reduce blood pressure. In people with predisposition to hypertension, these medicines are one of the important ways to normalize vital activity.

The composition of these drugs have substances that have a corrective effect on the pressure throughout the day, they prevent the onset of hypertensive seizures and carry out the prevention of diseases. What is the classification of sartans?

Mechanism of action

These drugs are not inferior in the effectiveness of popular medicines from increased blood pressure, practically do not provoke side effects, eliminate symptoms of hypertension, have a protective effect on the heart and vessels, as well as the kidney and brain. In addition, these drugs are referred to as blockers. angiotensin-II receptors.

Indications

Sartanes are prescribed with hypertension. They effectively lower the pressure, but the result can be noticed only after 3-4 weeks after the start of therapy. In addition, Sartans are prescribed in chronic heart failure, as well as they prevent heart defeat in the early stages.

Drugs of this group eliminate chronic heart failure, heart attacks and strokes. Sartans are effective in nephropathy.

In addition, receptor blockers to angiotensin II are used to eliminate the following states:

1. Diseases of the heart and blood vessels with a diabete of a second type.
2. Defeatness of the heart and vessels at dyslipidemia.

Classification of Sartan

According to the active substance, four groups note:

1. Telmisartan is nebiffenyl derivative of Tetrazole.
2. Eprosartan - Nebiffenyl is not tetrazole.
3. Valsartan is a non-cyclic connection.
4. Lozartan, Irbesartan and Kandesartan belong to the biphenyl derivatives of Tetrazole.

Sartans began to use only nineties of the last century. Today, you can find many brands with these substances in the composition. They are in any pharmacy.

Classification of sartan for generations:

1. Lozartan is produced under the following names: "Vasotenz", "Zisakar", "Lozell", "Lozartan", "Lotter", "Blocktrans".
2. Olmertan: "Cardosal", "Olimes".
3. Azilsartan: "Earby".
4. Eprosartan - Tevevent.
5. Valsartan is also available under the following trade names: "Valaar", "Voz", "Valsak", "Diva".
6. Iberzartan: "Ibertan", "Irsar", "Firmasta".
7. Kandesartan: "Angicand", "Ataandan", "Kandekor", "Ordissa".
8. Telmisarthane: "Macardis", "Pruiter".

In addition, ready-made combinations of sartans with diuretic drugs and calcium antagonists are produced. Next, the most popular hypotensive medicines will be considered.

"LOOP"

The medication contributes to a decrease in the total peripheral resistance of the vessels, and also has a diuretic effect, reduces post-loading and pressure in a small circulation circle.

What instructions for use, the price and reviews "Lozaz" have? People with chronic heart failure in the use of this drug rises tolerance to physical exercises, hyperrophy of the muscles of the heart is prevented.

The "Lozell" medicine contributes to uniform blood pressure control throughout the day, in accordance with circadian rhythms, does not provoke the cancellation syndrome. The cost of "Lozapa" varies from 120 to 1100 rubles.

People who suffer from cirrhosis of the liver, after applying the hypotensive drug, mark the high content of the active substance and its more active metabolism than in healthy patients. In connection with which it is necessary to make lower dosages.

With a violation of the kidney work, hypercalemia is possible. Therefore, during therapy, it is recommended to constantly monitor the level of this trace element.

With a combination of drugs that affect the renin-angiotensin system, people with kidney stenosis can increase the concentration of creatinine and urea. After stopping the preparation of the drug, the patient's condition is usually stabilized. The tool has positive feedback among patients, effectively lowers blood pressure and leads to normal.

It is also necessary to carry out regular laboratory control of the level of biochemical indicators of the function of the glomerular kidney apparatus, since the means is contraindicated to people with a violation of its operation.

Waltacor

The medication is a drug for oral administration, the pharmacological effect of which is aimed at stabilizing the level of blood pressure and improved heart and blood vessels.

The drug does not have an impact on the heart rate, in contrast to other medicines with a hypotensive effect. People who used Walsakor noted the elimination of shortness of breath, as well as extregnity edema and pain sensations In the field of heart.

The pharmacological effect from the use of medication is observed already two weeks after the start of therapy. The active substances of the drug provide the emergence of salts, chlorine, potassium and extra liquid. With a single use of the tablet therapeutic effect persists within twenty-four hours.

With therapy, the "Valscor" the patient may have reduced attention and deterioration of the reaction rate, which must be taken into account when driving a car.

This medication with extreme caution is prescribed to people with autoimmune inflammation of the walls of vessels and systemic red lupus, narrowing aorta and mitral valve, as well as patients with hypertrophic cardiomyopathy, which is accompanied by the obstruction of large blood vessels.

Dosing the drug and the duration of treatment determines the doctor individually for the patient. It depends on the diagnosis, as well as age, general status organism and other factors.

"Blottrans"

"Blocktat" can be used in conjunction with other medications from hypertension. It should be controlled by blood pressure, since it is proved that active substance Helps to have a hypotensive influence of drugs from beta-adrenobators, diuretic and sympatholytic drugs.

In people suffering from stenosis of the renal arteries, the medication provokes an increase in the content of urea and creatinine in the blood.

The use of "PLATTRAD" requires periodic control of the concentration of potassium in the blood, especially for kidney diseases and in patients of retirement age.

In renal disorders, the dosing of the medication is not reduced, but the patient's condition should be under the constant supervision of medical professionals. When lesions of the liver, it is necessary to reduce the concentration of the drug, as well as observe the condition of the organs and systems.

For people of retirement age, there is no need to adjust the dose. Children under eighteen years old are contraindicated to apply "Blocktat".

Symptoms of strong dosage excess serve:

• tachycardia;
• bradycardia;
• a pronounced decrease in blood pressure below the norm.

In case of poisoning, diuresis forced, as well as symptomatic treatment, liquidating arrhythmia and hypotension, are prescribed. Hemodialysis is not advised due to its inefficiency.

"DOVAN"

After one-time use, antihypertensive action is observed in the first two hours, and the maximum pharmacological effect Manifested four or six hours later. Efficiency after consumption continues more than a day.

A sharp discontinuation of the medication does not lead to a quick increase in blood pressure or other negative consequences. Clinical information confirm that "doda 80" does not affect the amount of uric acid, as well as general cholesterol, glucose and triglycerides in the blood.

The main component (valsartan) of the drug "doda" in a small amount accumulated in the body. He is eliminated by S. called masses And Urina.

In the treatment of people with medicine that suffer from essential arterial hypertension, it is not necessary to regularly monitor laboratory indicators.

In persons who have a pronounced lack of sodium in the body, sometimes the pressure and symptoms of arterial hypotension may occur at the beginning of treatment.

When the patient's hypotension appears, it is necessary to put with raised legs and introduce intravenously physical. After the normalization of blood pressure, therapy with the medicine "doda 80" can be continued further.

In people with renovascular hypertension, which appeared after the unilateral stenosis of the renal artery, the renal hemodynamics, the number of creatinine and nitrogen urea, does not change during treatment.

But, given that other similar medicines can increase the amount of creatinine and urea in the blood, it is important to comply with security measures and control these indicators.

Patients who have violations in the work of the kidneys do not necessarily adjust the dose. With significant lesions, therapy should be carried out with extreme caution.

"Macardis"

The drug from the classification of Sartan belongs to the telemisartan. With caution, the drug is prescribed to people with a narrowing of the mitral valve and aorta, as well as both renal arteries, obstructive hypertrophic cardiomyopathy, with lesions of the organs gastrointestinal tract, severe liver, kidney and heart disease.

Patients whose dehydration is observed due to diarrhea and vomiting, as well as therapy with diuretics, the medication is prescribed in minimal concentrations.

Contraindicated to use medicine to patients with intolerance to fructose and primary aldosteroneism. If pregnancy is planned, then before this should be replaced by McCardis.

With a combination of drug for treatment hypertensive disease With liquidia medicines, it is important to monitor the concentration of lithium in the body, since there is a chance of a temporary increase in its level.

With special care you need to use Macardis to patients who manage the car or are engaged in work requiring increased attention. The drug can provoke light dizziness or drowsiness.

In humans suffering from diabetes, coronary heart disease, either by other cardiovascular diseases due to the use of the medication increases the likelihood of the appearance of a fatal myocardial infarction and sudden death.

Heart ischemia with diabetes can flow without visible symptoms and not diagnosed initially. Therefore, before treating "Macardis", you need to diagnose, which defines the IBS.

The drug is allowed to be used together with diuretics, which have an additional hypotensive effect. Recommended dosages for complex treatment with hydrochlorodiazide are: "Mycardis" 40 mg or 80 mg + 12, 5 mg of diuretic substance.

"Earbi"

According to the instructions for use, the azilsartan is part of the hypotensive drug. After the start of treatment, a clinically significant hypotension may appear in people with a reduced amount of circulating blood. Before therapy, hypovolemia must be adjusted. Start using "Earby" is necessary with 20 milligrams per day.

People with primary hyperaldosteronism in most situations are resistant to treatment with hypotensive drugs that affect the renin-angiotensin-aldosterone system, so the medication is not recommended to assign.

In patients with hypertension comprehensive treatment Medicine "Earbi" with potassium-saving diuretic products or substitutes of potassium salts can lead to hypercalemia.

In patients of retirement age, with kidney diseases, as well as diabetes mellitus or other concomitant diseases, the risk of hypercalemia increases, including fatal. This category of people is advised to monitor the concentration of potassium in the blood.

"VOLZ"

Before starting therapy, this medicine needs to restore the level of electrolytes and fluid. To do this, reduce the concentration of diuretic agents. If a person has renovascular hypertension, it is necessary to ensure regular control of the level of creatinine and urea in the blood.

According to the instructions for use, it is known that when using the preparation-sardan in chronic heart failure at the very beginning of therapy, blood pressure can be reduced, therefore its regular control is important.

In the treatment of medicine, there are sometimes changes in the functioning of the kidneys. During the course of therapy, drugs must be safely managed by car and engage in other activities that require increased attention.

"Cardosal"

According to the instructions for use, Olmertan is part of the drug. The medication is made in tablet form, it is intended for oral administration. When using the drug, people with a violation of the kidney function, it is necessary to constantly control potassium and creatinine in the blood.

It must be remembered that a strong decrease in pressure in patients with heart ischemia or cerebral changes can cause a heart attack or stroke. Driving a car during therapy by this drug requires care.

According to the instructions for use, Olmertan is not recommended to simultaneously apply with potassium medicines, potassium-saving diuretic agents or other drugs that are able to increase the concentration of potassium in the blood. The hypotensive effect of therapy Olmertan is intensified when comprehensive application with other antihypertensive means.

Arterial hypertension is a stable increase in blood pressure, which varies within 145/95 mm Hg. Art. but can rise and above. During therapy of this disease, it is necessary to be extremely attentive with the choice of drugs. How already showed the practice of treatment, optimal and effective method You can consider sartans for arterial hypertension. This kind of preparations - sconium (angiotensin receptor blockers), many years have clearly demonstrate their quality, efficiency and impact on the body.

Brony action mechanism

The main task of angiotensin receptor blockers - the oppression of the activity of Raas, thereby this process has a positive effect on the work of many human bodies. Sartans are considered best drugsFollowing the list medicinal groups from high pressure. It should be noted that the price policy of these drugs is significantly different from the branded drugs - they have more affordable. According to the statistics of the Sartan reception - 70% of patients are conducting courses of therapy up to several years, while the level of performance of a particular organ is not reduced.

These facts may only indicate that angiotensin receptor blockers have a minimum list of side effects, and some are not at all.

With regard to confirmation or refutation of the fact that Sartans cause cancer, this type of disputes is still under thorough control.

Groups

By chemical properties You can divide the sconce on 4 subspecies:

1. Bifenyl formed from Tetrazole - Losartan, Irbesartan, Candesartan.
2. Nebifenolized formed from Tetrazole - Telmisartan.
3. Nebifenol Netzetrazole - EPROSARTAN.
4. Non-cyclic compounds - Valsartan.

To introduce this kind of drugs to the process of arterial hypertension therapy has become since the 1990s, and at the moment it is possible to note a rather considerable list of drugs:

• Lozartan: Blocktatran, Vasotenz, Zisakar, Karzarttan, Kozar, Losarel, Lozartan, Lorist, Losakor, Lotor, Prezartan, Renyikard;
• Eprosartan: Teveven;
• Valsartan: Valaar, Valsafors, Valsakor, Diva, Nortivan, Tantordio, Tareg;
• Irbesartan: Approvnel, Ibertan, Irsar, firma;
• Kandesartan: Angicand, Ataandan, Candarent, Candesar, Ordiss;
• Telmisartan: Macardis, Pruiter;
• Olmertan: Cardosal, Olimes;
• Azilsartan :.

In addition to the above, you can meet from the classification of these drugs and combined components: with diuretics, with CA antagonists, with antagonists Renin Aliskiren.

Scope of Science Bra

Angiotensin II receptor blockers give the highest efficacy with diseases such as:

• arterial hypertension;
• insufficient performance of the heart muscle;
• Problems with the work of the cerebral blood system;
• Glucose shortage in the body;
• Nephropathy;
• Atherosclerosis;
• Sexual disorders.

Any of drugs, with antihypertensive effects, allowed to assign, even in a complex with other dosage forms. Type of preparations A - II is often prescribed when they are more preferable. In this case, they can be considered better than the ACE inhibitors at elevated pressure, sharp blood pressure jumps. Inhibitors often happen allergic reactionIt is practically impossible when using Sartan, as well as their positive parties can be allocated in terms of reception during the development of 2 types of diabetes, as well as nephropathy, which cannot be said about ACE.

From contraindications, the following types of population can be distinguished: women in the position, the lactation period, childhood From birth up to 14 years old. Caution is accepted in disabilities of the kidneys, liver.

Impact

Bra - this is primarily effective drugs from pressure. But the result of therapy with these medicine can be different, depending on the degree of development of the disease. In the case when the pressure is consistently elevated, the A-II antagonists can show good efficiency.

Modern drugs - Sartans are considered one of the best on the impact on such organs as kidneys, heart, liver, brain, etc.

The main positive moments in the reception of Sartan can be considered:

• When taking this kind of drugs, the tag of the pulse is not observed;
• With constant drug intake, pressure jumps do not occur;
• With insufficient work of the kidney, under the influence of these drugs there is a decrease in protein;
• Reduced level of cholesterol, glucose, acid in the urine;
• Positively affect the lipid process;
• Improving sexual ability;
• During the reception of Sartan, a dry cough was noticed.

It's important to know! During the course of a sharp stroke, it is not recommended to use drugs to reduce pressure within 5-8 days. Exception can only be over high rates Pressure.

It should also be aware that Sartans have a beneficial effect on muscle tissues, especially good for those patients who have missed Miodistrophi.

It's important to know! With the flow of bilateral narrowing of the renal artery, the agent for therapy of Ara is strictly forbidden to take - kidney failure can develop.

What better to purchase?

Provide information about the best sconce just unrealistic, as there are quite a large amount in their quantity and diversity effective drugs, But each of them has its own functions. According to clinical Studies It was revealed, which sartans can help with a certain disease:

It's important to know! During therapy, it is strictly forbidden to assign two or more types of Sartan simultaneously!

Advantages over other drugs

During the treatment of arterial hypertension, preparations should be aware of the preparations that cardiologists will be prescribed:

• This kind of drugs can be used to receive more than several years;
• Side effects in this case are either minimum or absent;
• With therapy of arterial hypertension, the reception of the tablets must be up to two times at 12 o'clock;
• Reduction of blood pressure occurs not sharply, within 20-24 hours;
• With a stable pressure (120/80), when receiving sartans, the pressure will not further decrease further;
• Patients are not accustomed to this kind of drugs;
• With a sharp not use of drugs of this group, there will be no sharp pressure jumps;
• Modern types of drugs have high efficiency and reception quality during therapy and prevention.

A warning! After the first reception of the blockers, do not wait for the quick result. They are not capable of fast decline Hell, but are able to bring it back for 10-15 days, and a stronger effect - after 20-25 days of reception.

Reception of drugs must be implemented as follows (example):

The interaction of sartan and diuretic drugs

Often, cardiologists insist on the therapy of the sconium and diuretic products.

Many pharmacy points have a considerable amount of pressure pills, which include sartans and diuretic products:

• Ataandan - 0.16 g Candesartan and 12.5 mg Hydrochlorothiazide;
• Co-doda - 80 mg valsartan and 12.5 mg Hydrochlorothiazide;
• Lorist - 12.5 mg Hydrochlorothiazide and 50-100 mg of losartan;
• McCardis - 80 mg of televisartan and 12.5 mg Hydrochlorothiazide;
• Teveven - Eprosartan - 600 mg and 12.5 mg HydrochlorOrothiazid.

In conclusion, I would like to note that according to medical research, all the above-mentioned scores in arterial hypertension, have a protective effect not only to work the heart, but also for many internal organs Thereby, thereby reducing the risk of stroke, heart attack, heart failure, MBS and many other serious diseases.

Sartans are preparations of a new generation, which are used to reduce blood pressure in arterial hypertension. The first variants of these types of drugs were synthesized in the early 90s of the last century.

The mechanism of the action of drugs is to suppress the activity of the renin-angiotensin-aldosterone system, which is favorably reflected on human health.

Sartans are not inferior on the efficiency of well-known drugs from increased pressure, they practically do not cause side effects, eliminate hypertension symptoms, have a protective effect on the cardiovascular system, kidneys and a brain. Also, such drugs are called angiotensin-II receptor blockers or angiotensin receptor antagonists.

If we compare all the preparations from arterial hypertension, the Sartans are considered the most effective drugs, while the price is quite affordable. As medical practice shows, many sartan patients are steadily accepted for several years.

This is due to the fact that such drugs from high pressure, to which eprosartan and other means belong to the minimum of side effects.

Including patients on them there is no reaction in the form of a dry cough, which is often occurring during the reception of ACE inhibitors. As for the approval that drugs can provoke cancer, this issue is on a thorough study.

Sartans and treatment of arterial hypertension

Initially, Sartans were developed as a drug from high pressure. As scientific research has shown, drugs such as eprosartan and others are capable of reduced blood pressure as efficiently as the main form of medicines against hypertension.

Angiotensin-II receptor blockers are taken once a day, these medicines smoothly reduce blood pressure indicators during the day.

The effectiveness of the action of drugs directly depends on the degree of activity of the renin-angiotensional system. The most efficient is the treatment of patients who have a high activity of renin in blood plasma. To identify these indicators, the patient is prescribed a blood test.

Eprosartan and other sartans, prices for which preparations are comparable to similar on the target effect, reduce blood pressure long period (on average for 24 hours).

The persistent therapeutic effect can be seen after two or four weeks of continuous treatment, which is significantly intensified at the eighth week of therapy.

Advantages of drugs

In general, the medicine of such a group has enough positive feedback from doctors and patients. Sartans have numerous advantages over traditional drugs.

1. With long-term use of the medication for more than two years the drug does not cause dependence and addiction. If you sharply stop taking medication, it does not provoke a sharp increase in blood pressure.
2. If a person has normal blood pressure, the sartans do not lead to an even stronger decrease in the indicators.
3. Angiotensin-II receptor blockers are better transferred to patients and practically do not cause side effects.

In addition to the main function of lowering blood pressure, drugs have a favorably affect the operation of the kidneys in the presence of a diabetic nephropathy in a patient. Sartans also contribute to the regression of the Hypertrophy of the left ventricle of the heart and improving the indicators in people with heart failure.

For better therapeutic effect, angiotensin-II receptor blockers are recommended to be taken in combination with diuretic drugs in the form of dichloatiazide or indapamide, it enhances the effect of the drug one and a half times. As for thiazide diuretics, they have not only reinforcing, but also the extensive effect of blockers.

Additionally, Sartans have the following clinical effect:

• The cells of the nervous system are protected. The drug protects the brain in arterial hypertension, reduces the risk of stroke. Since the medicine directly acts on brain receptors, it is often recommended to patients with normal indicators Pressures having a high risk of vascular disaster in the brain area.
• Due to the antiarrhythmic effect, patients decreases the risk of atrial fibrillation.
• With the help of a metabolic effect with regular drug intake, the risk of the development of a diabetes of the second type is reduced. In the presence of a similar disease, the patient's condition is quickly adjusted by reducing tissue insulin resistance.

When using drugs, the patient improves lipid exchange, cholesterol and triglycerides are reduced. Sartanes contribute to a decrease in the amount of uric acid in the blood, which is necessary in the case of long-term treatment with diuretics. In the presence of a disease of the connecting tissues, the walls of the aorta are strengthened and the gap is prevented. In patients with Miodistrophia Duzhenna, the condition of muscle tissues is improved.

The price of drugs depends on the manufacturer and duration of the drug. Lozartan and Valsartan are considered the cheapest options, but they have a shorter validity period, therefore require more frequent reception.

Classification of drugs

Sartans are classified by chemical composition and effect on the body. Depending on whether active metabolite is in medicine, drugs are divided into so-called prodrugs and active substances.

According to chemical composition, Sartans are divided into four groups:

1. Kandesartan, Irbesartan and Lozartan are biphenyl derivatives of Tetrazole;
2. Telmisarthane performs nebiffhenyl derivatives of Tetrazole;
3. Eprosartan is nebiffenyl netsole;
4. Valsartan is considered non-cyclic compound.

In modern times, there are a large number of drugs of this group that can be purchased at the pharmacy without the presentation of the doctor's prescription, among which Eprosartan, Lozartan, Valsartan, Irbesartan, Kandesartan, Telmisartan, Almertan, Azilsartan.

Additionally, in specialized stores, you can buy a ready-made combination of sartans with calcium antagonists, diuretics, an antagonist for the secretion of Renin Aliskiren.

Instructions for use of the drug

Reception The doctor appoints individually, after the full examination. The dosage is drawn up according to information that displays the instructions for the use of the drug. IMPORTANT TO TAKE medicine Every day to avoid passes.

The doctor prescribes the reception of angiotensin-II receptor blockers when:

• Heart failure;
• Suffered myocardial infarction;
• Diabetic nephropathy;
• Proteinuria, microalbuminuria;
• Hypertrophy of the left ventricle of the heart;
• Atrial fibrillation;
• Metabolic syndrome;
• Intolerance to ACE inhibitors.

According to the application instructions, in contrast to ACE inhibitors, Sartans do not contribute to increasing the level of protein in the blood, which often leads to an inflammatory response. Due to this, the drug does not have such side effects as angioemical shock and cough.

In addition to the fact that eprosartan and other drugs reduce blood pressure in arterial hypertension, they additionally have a positive effect on other internal organs:

1. Reduced hypertrophy of the mass of the left ventricle of the heart;
2. The diastolic function improves;
3. Zastricultural arrhythmia decreases;
4. The selection of protein is reduced through the urine;
5. Increases blood flow in the kidneys, while the speed of glomerular filtration is reduced.
6. Does not affect the indicators of sugar, cholesterol and purines in the blood;
7. The sensitivity of the tissue is increasing to insulin, due to which insulin resistance decreases.

Researchers held many experiments on the effectiveness of the drug in the treatment of arterial hypertension and the availability of advantages. Participation in experiments took patients with a violation of the work of the cardiovascular system, due to which it was possible to test the mechanism of operation drugs and prove the high efficiency of the drug.

At the moment, research is underway whether Sartan is capable of provoking cancer.

Sartan with diuretic drugs

A similar combination efficiently eliminates the arterial hypertension, and angiotensin-II receptor blockers when using diuretics have a uniform and long impact on the body.

There is a specific list of drugs, which contain a certain amount of sartan and diuretic drugs.

• The composition of Atacand Plus includes 16 mg of Kandesartan and 12.5 mg of hydrochlorotiazide;
• Coadovan contains 80 mg of valsartan and 12.5 mg of hydrochlorotiazide;
• The Lorist ND / ND preparation contains 12.5 mg of hydrochlorotiazide and 50-100 mg of losartan;
• The McCardis Plus medicine includes 80 mg of telmisartan and 12.5 mg of hydrochlorotiazide;
• The composition of teveten PLUS includes Eprosartan in the amount of 600 mg and 12.5 mg of hydrochlorotiazide.

As practice and numerous positive feedback from patients shows, all these drugs included in the list are well helped with arterial hypertension, have a protective effect on the internal organs, reduce the risk of developing stroke, myocardial infarction, renal failure.

All these drugs relate to safe, as practically no side effects. Meanwhile it is important to understand that therapeutic effect is usually visible immediately. It is objective to assess whether the drug helps at elevated pressure, you can only after four weeks of constant treatment. If this is not taken into account, the doctor may hurry and appoint a new drug stronger action, which will negatively affect the patient's health.

The effect of the drug on the heart muscle

When decreasing blood pressure indicators during the reception of sartan, the patient does not increase the frequency of heart abbreviations. A special positive effect can be observed with the blockade of the activity of the Renin-angiotensin-aldosterone system in the vascular walls and myocardium areas. It protects against hypertrophy of blood vessels and hearts.

Such a feature of the drugs is especially useful in the presence of a patient with hypertensive cardiomyopathy, ischemic DiseaseCardiosclerosis. Additionally, sartans reduce atherosclerotic damage to the blood vessels.

Action Medication on the kidneys

As you know, with arterial hypertension, the kidneys are the target organ. Sartans in turn contribute to a decrease in the selection of protein in the urine in people with kidney damage in diabetes and hypertension. Meanwhile, it is important to take into account that in the presence of one-sided stenosis of the renal artery, angiotensin-II receptor blockers often increase the level of plasma creatinine and cause acute renal failure.

Due to the fact that the drugs suppress the inverse suction of sodium in the proximal canal, oppress the synthesis and release of aldosterone, the body is getting rid of salt through the urine. This mechanism in turn causes a certain diuretic effect.

1. Compared to Sartan, when using ACE inhibitors, a side effect is observed in the form of a dry cough. This symptom sometimes becomes so strong that patients have to abandon the use of medication.
2. Sometimes the patient develops angioedema edema.
3. Also, specific kidney complications include a sharp decrease in glomerular filtration rate, which causes increasing potassium performance and creatinine in the blood. The risk of developing complications in patients with atherosclerosis of renal arteries, congestive heart failure, hypotension and decrease in blood circulation volume is especially large.

In this case, Sartans are the main drug, which slowly reduces the speed of glomerular filtration of the kidneys. Due to this, the amount of creatinine in the blood does not increase. Additionally, the medicine does not allow to develop nephrosclerosis.

The presence of side effects and contraindications

Preparations have a healing effect, similar placebo, so they have a minimum of side effects and are well tolerated, compared to ACE inhibitors. Sartans do not cause a dry cough, also the risk of the appearance of angioedema edema is minimal.

But it is necessary to take into account that angiotensin II receptor blockers in some cases are able to quickly reduce blood pressure due to the activity of renin in the blood plasma. With a bilateral narrowing of the renal arteries, the patient may break the work of the kidneys. Sartans are not allowed for use during pregnancy, as this negatively affects the development of the fetus.

Despite the presence of undesirable effects, Eprosartan and other sartans belong to drugs that are well tolerated and rarely cause adverse reactions In the treatment of high pressure. The medicine is well combined with other drugs against hypertension, the best healing effect is observed during the additional use of diuretic drugs.

Also, there are no disputes of researchers about the feasibility of using Sartan, given the fact that these drugs can provoke cancer at a certain situation.

Sartan and cancer

Since angiotensin eprosartan receptor blockers and others use an angiotensin-regenine system action mechanism, angiotensin type 1 and type 1 receptors are involved in the process. These substances are responsible for the regulation of cell proliferation and tumor development, which provoke cancer.

To find out whether the risk is really great that patients taking regular sardans can develop cancer, numerous scientific research was conducted. As the experiment showed, in patients taking blockers angiotensin receptors, the risk of developing oncology became higher, compared with those people who did not accept the medicine. Meanwhile, cancer with the same risk leads to death as after receiving the drug, and without it.

Despite the conclusions obtained, the doctors still cannot accurately answer the question, whether Eprosartan and other sartans are provoking oncological disease. The fact is that the absence of complete data on the involvement of each drug to cancel diseases doctors cannot argue that Sartans cause cancer. Today, research on this topic is actively continuing, and researchers are very ambiguous in this matter.

Thus, the question remains open, despite the similar effect, provoking cancer, doctors consider Sartan a truly effective medicine, which can be an analogue of traditional drugs from hypertension.

However, there are certain angiotensin receptor blockers that help to treat cancer. In particular, this refers to the lung and pancreatic cancer. Also, some types of drugs are used during chemotherapy in hypertensive, which have pancreatic cancer, esophagus and stomach. Interesting video This article will summarize the discussion about Sartan.