Spironolactone (spironolactone)

Composition and release form of the drug

Pills white or white with a yellowish tinge, round, flat-cylindrical, with a line on one side and bevel on both sides, with a characteristic odor.

Excipients: lactose monohydrate (milk sugar) - 117 mg, corn starch - 50 mg, K25 - 5 mg, magnesium stearate - 2 mg, colloidal silicon dioxide - 1 mg.

10 pieces. - blister packs (1) - cardboard packs.
10 pieces. - blister packs (2) - cardboard packs.
10 pieces. - blister packs (3) - cardboard packs.
10 pieces. - blister packs (4) - cardboard packs.
10 pieces. - blister packs (5) - cardboard packs.
20 pcs. - blister packs (1) - cardboard packs.
20 pcs. - blister packs (2) - cardboard packs.
20 pcs. - blister packs (3) - cardboard packs.
20 pcs. - blister packs (4) - cardboard packs.
20 pcs. - blister packs (5) - cardboard packs.
10 pieces. - jars made of polyethylene terephthalate (1) - cardboard packs.
20 pcs. - jars made of polyethylene terephthalate (1) - cardboard packs.
30 pcs. - jars made of polyethylene terephthalate (1) - cardboard packs.
40 pcs. - jars made of polyethylene terephthalate (1) - cardboard packs.
50 pcs. - jars made of polyethylene terephthalate (1) - cardboard packs.
100 pieces. - jars made of polyethylene terephthalate (1) - cardboard packs.

pharmachologic effect

Potassium-, magnesium-sparing diuretic. It is a competitive antagonist of aldosterone in terms of its effect on distal parts nephron (competes for binding sites on cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent area of ​​the collecting ducts and distal tubules), increases the excretion of Na +, Cl - and water and reduces the excretion of K + and urea, and reduces the titratable acidity of urine. Increased diuresis causes a hypotensive effect, which is variable. The antihypertensive effect does not depend on the level of renin in the blood and does not manifest itself at normal blood pressure.

The diuretic effect appears on days 2-5 of treatment.

Pharmacokinetics

After oral administration, it is absorbed from the gastrointestinal tract, absorption is 90%. It is metabolized in the liver, the main active metabolite is canrenone.

T 1/2 is 13-24 hours. It is excreted mainly by the kidneys, a certain amount is excreted in the bile.

Indications

Edema in chronic heart failure, cirrhosis of the liver (especially with the simultaneous presence of hypokalemia and hyperaldosteronism), with nephrotic syndrome.

Edema in the II and III trimesters of pregnancy.

Arterial hypertension, incl. with aldosterone-producing adrenal adenoma (as part of combination therapy).

Primary hyperaldosteronism. Aldosterone-producing adrenal adenoma (long-term maintenance therapy with contraindications to surgical treatment or in case of refusal). Diagnostics of the hyperaldosteronism.

Hypokalemia and its prevention in the treatment of saluretics.

Polycystic ovary syndrome, premenstrual syndrome.

Contraindications

Addison's disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, hepatic failure, diabetes mellitus with confirmed or suspected chronic renal failure, diabetic nephropathy, I trimester of pregnancy, metabolic acidosis, violation menstrual cycle or breast enlargement, hypersensitivity to spironolactone.

Dosage

Set individually, depending on the severity of violations of water-electrolyte metabolism and hormonal status.

With edematous syndrome - 100-200 mg / day (less often - 300 mg / day) in 2-3 doses (usually in combination with a "loop" or / and thiazide diuretic) daily for 14-21 days. Dose adjustments should be made taking into account the values ​​of the concentration of potassium in the plasma. If necessary, courses are repeated every 10-14 days. With pronounced hyperaldosteronism and a reduced content of potassium in plasma - 300 mg / day in 2-3 doses.

Side effects

From the side digestive system: nausea, vomiting, abdominal pain, gastritis, ulceration and bleeding in the gastrointestinal tract, intestinal colic, diarrhea or constipation.

From the side of the central nervous system: dizziness, drowsiness, lethargy, headache, lethargy, ataxia.

From the side of metabolism: increased urea concentration, hypercreatininemia, hyperuricemia, impaired water-salt metabolism and acid base balance (metabolic hypochloremic acidosis or alkalosis).

From the hematopoietic system: megaloblastosis, agranulocytosis, thrombocytopenia.

From the side endocrine system: at long-term use- gynecomastia, erectile dysfunction in men; in women - dysmenorrhea, amenorrhea, metrorrhagia in menopause, hirsutism, coarsening of the voice, breast tenderness, breast carcinoma.

Allergic reactions: urticaria, maculopapular and erythematous eruptions, drug fever, pruritus.

Others: muscle spasms, decreased potency.

Drug interactions

When used simultaneously, the hypotensive effect of spironolactone is potentiated.

With simultaneous use with ACE inhibitors, hyperkalemia may develop (especially in patients with impaired renal function), because ACE inhibitors reduce the content of aldosterone, which leads to a retention of potassium in the body against the background of limited excretion of potassium.

With simultaneous use with potassium preparations, other potassium-sparing diuretics, table salt substitutes and dietary supplements containing potassium, hyperkalemia may develop.

With simultaneous use with salicylates, the diuretic effect of spironolactone decreases due to the blockade of canrenone excretion by the kidneys.

And mefenamic acid inhibits renal excretion of canrenone.

With simultaneous use, the hypoprothrombinemic effect of oral anticoagulants decreases.

When used simultaneously with digitoxin, it is possible to both increase and decrease the effects of digitoxin.

With the simultaneous use of spironolactone inhibits the excretion of digoxin by the kidneys and, probably, reduces its volume of distribution. This can cause an increase in the concentration of digoxin in the blood plasma.

With simultaneous use with, losartan, eprosartan, there is a risk of developing hyperkalemia.

With simultaneous use with cholestyramine, cases of hypochloremic alkalosis have been described.

With simultaneous use with lithium carbonate, an increase in the concentration of lithium in the blood plasma is possible.

With simultaneous use with it is possible to reduce the sensitivity of blood vessels to norepinephrine.

With simultaneous use, the effect of triptorelin, buserelin, gonadorelin is enhanced.

special instructions

Use with caution in AV blockade (the possibility of strengthening due to the development of hyperkalemia), decompensated liver cirrhosis, surgical interventions, taking drugs that cause gynecomastia, when taking local and general anesthetics, in elderly patients.

Against the background of the use of spironolactone, drugs containing potassium, as well as other diuretics that cause potassium retention in the body, should not be prescribed. The use of spironolactone with carbenoxolone, which causes sodium retention, should be avoided.

During the period of treatment, periodic determination of the content of electrolytes and urea in the blood should be carried out.

When using spironolactone in combination with other diuretic or antihypertensive drugs, it is recommended to reduce the dose of the latter. When spironolactone is used concomitantly with digoxin, it may be necessary to reduce both the saturating and maintenance dose of the latter.

Contraindicated in liver failure. Use with caution in decompensated liver cirrhosis.

Use in the elderly

Use with caution in elderly patients.

Recipe (international)

D.t.d: No. 20 in tab.
S: 1 tab. in the morning inside.

Recipe (Russia)

Rp: Tab. Spironolactoni 0.025
D.t.d: No. 20 in tab.
S: 1 tab. in the morning inside.

Prescription form - 107-1 / y

Active substance

pharmachologic effect

Diuretic, potassium-sparing, antihypertensive.
Competes with aldosterone for binding sites on cytoplasmic mineralocorticoid receptors. Inhibits aldosterone-regulated exchange of sodium ions for potassium ions in the collecting ducts and distal tubules. It inhibits the reabsorption of sodium ions through the apical membrane of the cells of the renal epithelium, increases the excretion of sodium, chlorine and water ions with urine, reduces the secretion and excretion of potassium (potassium-sparing effect), magnesium, urea and increases their concentration in the blood. Reduces the titratable acidity of urine. It has a moderate long-term diuretic effect and a weak antihypertensive effect. The diuretic effect after taking multiple doses appears on the 2-5th day and lasts for 2-3 days after stopping the intake. Spironolactone as a diuretic is most effective in edema associated with increased production of aldosterone, especially when a potassium-sparing diuretic effect is desired, incl. with congestive heart failure, liver cirrhosis and nephrotic syndrome. The potassium-sparing effect makes it possible to use it for hypokalemia caused by other diuretics, as well as for hypersensitivity to digitalis drugs due to hypokalemia.

Antihypertensive activity is due to an increase in the excretion of sodium ions and a decrease in BCC and extracellular fluid. Spironolactone is most effective for reducing elevated SBP and DBP in patients with primary hyperaldosteronism, in most cases of essential hypertension (even though the level of aldosterone secretion in benign essential hypertension may be within normal limits). The hypotensive effect is manifested in the 2-3rd week of treatment.

Carcinogenicity, mutagenicity, effects on fertility

In studies of chronic toxicity in rats, the oncogenic effect of spironolactone has been established, especially in relation to the endocrine organs and the liver. In one study, male rats treated with spironolactone at doses 25, 75, and 250 times higher than daily dose for humans (2 mg / kg), there was a statistically significant dose-dependent increase in the incidence of benign adenomas thyroid gland and testicles. Female rats showed a statistically significant increase in frequency malignant tumors breast when using medium doses. In male rats, a dose-dependent increase in the frequency of proliferative changes in the liver was found. At the highest level doses (500 mg / kg), the revealed effects included hepatocytomegaly, foci of hyperplasia, and hepatocellular carcinoma (the development of the latter was not statistically significant at p = 0.05). Dose-dependent (at doses over 20 mg / kg / day) cases of myelocytic leukemia were observed in rats fed daily with food for 1 year with potassium canrenoate. In long-term (two-year) carcinogenicity studies of potassium canrenoate in rats with oral administration myelocytic leukemia and tumors of the liver, thyroid gland, testicle and breast were observed. Potassium canrenoate did not cause mutagenic effects in tests using bacteria or yeast. It caused a mutagenic effect in some in vitro tests on mammalian cells after metabolic activation, but was not mutagenic in vivo. The main metabolites of potassium canrenoate are canrenone and canrenoic acid. Spironolactone is also metabolized to canrenone. An increase in the incidence of leukemia was not observed in the study of chronic toxicity in rats using spironolactone doses up to 500 mg / kg / day.

When taken orally, it is well absorbed from the gastrointestinal tract (bioavailability is more than 90%), absorption increases when taken simultaneously with food (bioavailability is almost 100%). It is rapidly and extensively biotransformed in the liver with the formation of several sulfur-containing metabolites, incl. 7-alpha-thiomethylspirolactone (TMS), 6-beta-hydroxy-7-alpha-thiomethylspirolactone (GTMS) and the main active metabolite, canrenone. Antimineralocorticoid activity of spironolactone metabolites was assessed in adrenalectomized rats and was 1.10 for canrenone, TMS and GTMS; 1.28 and 0.32 activities of spironolactone, respectively; the affinity of metabolites in relation to aldosterone receptors in rat kidneys was 0.19; 0.86 and 0.06 that of spironolactone, respectively. In humans, the ability of TMS and 7-alpha-thiospirolactone to restore the electrolyte composition of urine, changed under the influence of a synthetic mineralocorticoid - fludrocortisone, was 0.33 and 0.26 compared with spironolactone, respectively.

The binding of spironolactone and canrenone to blood plasma proteins is more than 90%. Spironolactone and its metabolites pass through the placental barrier, canrenone penetrates into breast milk... With a daily intake of 100 mg for 15 days in 12 healthy volunteers, C_max of spironolactone was reached 2.6 hours after the next morning intake and amounted to 80 ng / ml, C_max of canrenone (181 ng / ml) was recorded after 4.3 hours, TMS (391 ng / ml) - after 3.2 hours, GTMS (125 ng / ml) - after 5.1 hours.It is excreted mainly in the urine in the form of metabolites, 10% - unchanged, and also in the form of metabolites with bile / feces ... T_1 / 2 of spironolactone - 10 minutes, T_1 / 2 of canrenone is 13-24 hours (on average 19 hours) when taken 1-2 times a day, 9-16 hours (on average 12.5 hours) when taken 4 times a day ... It was reported about the possibility of using spironolactone alone or as an additional agent in the treatment of hirsutism in women with polycystic ovary syndrome, with premenstrual syndrome, with familial premature puberty in young men, with bronchopulmonary dysplasia in children; to treat acne (acne vulgaris) and relieve altitude sickness.

Mode of application

For adults: Inside.
The dosage regimen is set individually. Usual Adult Doses: 25-200 mg / day in one or more divided doses; if necessary, the dose is increased to 400 mg / day.

Precautions: Prescribed with caution during surgery against the background of local and general anesthetics, elderly patients (increased risk of hyperkalemia). You should not prescribe spironolactone in conjunction with drugs that cause gynecomastia.
At doses over 100 mg / day, endocrine / antiandrogenic effects develop more often, an effect on the central nervous system and irritation of the gastrointestinal mucosa are manifested. During therapy, it is necessary to carefully monitor the content of electrolytes, the level of urea nitrogen, urea and creatinine in the blood (especially in elderly patients with impaired renal and / or liver function), regularly monitor blood pressure.
With the development of hyperkalemia, you should stop taking spironolactone. Avoid ingestion of excessive amounts of potassium, incl. exclude or limit foods rich in potassium (potatoes, apricots, raisins, tomato juice etc.), as well as drugs containing potassium.

When treating with spironolactone, alcohol should be avoided. At the beginning of treatment with spironolactone to drivers Vehicle and people whose profession is associated with increased concentration of attention should not use it while working. When conducting a glucose tolerance test in patients with diabetic nephropathy, spironolactone should be canceled at least 3 days before the test (due to the risk of severe hyperkalemia).
For kids: Inside.
Children are usually prescribed at the rate of 3 mg / kg / day, once or in 2 doses, the dose is selected individually.

Indications

Edematous syndrome in chronic heart failure
- cirrhosis of the liver (especially with the simultaneous presence of hypokalemia and hyperaldosteronism)
- nephrotic syndrome;
- essential hypertension in adults;
- ascites;
- diagnosis and treatment of primary hyperaldosteronism (Conn's syndrome);
- prevention of hypokalemia in the treatment of saluretics and in patients receiving cardiac glycosides, myasthenia gravis (adjuvant).

Contraindications

Hypersensitivity
- Addison's disease
- acute or rapidly progressive renal failure
- chronic renal failure with a significant decrease in excretory function (Cl creatinine less than 10 ml / min)
- anuria
- hyperkalemia
- hyponatremia
- hypercalcemia.

Restrictions on use: Decreased renal excretory function, impaired liver function (increased sensitivity to changes electrolyte balance), diabetes mellitus (especially diabetic nephropathy), a predisposition to metabolic acidosis (with acidosis, the hyperkalemic effect of spironolactone increases, spironolactone can contribute to the development of acidosis), menstrual irregularities and / or enlargement of the mammary glands, AV blockade (possibly increased due to the development of hyperkalemia) ...

Application during pregnancy and lactation: There are no data on the negative effect of spironolactone on the course of pregnancy and fetal development. However, the use of spironolactone is contraindicated in the first trimester of pregnancy. In the II and III trimester of pregnancy, it is possible only for strict indications, if the expected effect of therapy outweighs the potential risk to the fetus. At the time of treatment should be discontinued breast-feeding(canrenone, an active metabolite of spironolactone, passes into breast milk).

Side effects

- From the side nervous system and sense organs:
dizziness, drowsiness, lethargy, lethargy, headache, ataxia, confusion.
- On the part of the digestive tract:
nausea, vomiting, diarrhea, cramps, intestinal colic, gastritis, ulceration and bleeding in the gastrointestinal tract, abnormal liver function.
- From the genitourinary system:
gynecomastia (usually reversible, in rare cases it can persist after drug withdrawal), pain in the mammary glands, erectile dysfunction in men, decreased potency in men, menstrual irregularities or amenorrhea, metrorrhagia in menopause, hirsutism, voice change in women.
- on the part of the skin:
maculopapular or erythematous skin rash, alopecia, hypertrichosis, pruritus, urticaria.

Others: cramps of the calf muscles, benign neoplasms of the mammary gland, chest pain, leukopenia (including agranulocytosis), thrombocytopenia, electrolyte imbalance, hyperkalemia, increased blood urea nitrogen, creatinine, osteomalacia, drug fever.
Cases of breast cancer have been reported in men and women treated with spironolactone, but a causal relationship has not been established.

Release form

Produce tablets of 0.025 g (25 mg), 10 tablets per pack.

ATTENTION!

The information on the page you are viewing was created for informational purposes only and does not in any way promote self-medication. The resource is intended to familiarize healthcare workers with additional information about certain medications, thereby increasing their level of professionalism. The use of the drug "" without fail provides for a consultation with a specialist, as well as his recommendations on the method of application and dosage of the medicine you have chosen.

Is a synthetic aldosterone antagonist, is.

The drug is a potassium and magnesium-sparing diuretic. Competitive antagonist aldosterone, increases the excretion of Cl-, water and Na +, reduces the excretion of urea and K +, reduces the titratable acidity of urine. Diuresis causes an unstable hypotensive effect that does not depend on the level of renin in the blood plasma and does not manifest itself at normal blood pressure.

Application

Edema syndrome caused by chronic heart failure or liver cirrhosis. With hyperaldesteronism, with Conn's syndrome, with hypokalemia.

Side effect

Gynecomastia, impotence, hyperkalemia, acidosis, vomiting, diarrhea, stomach pains and cramps, dry mouth, thirst, dizziness.

Contraindications

Hypersensitivity, Addison's disease, hyperkalemia, hypercalcemia, hyponatremia, chronic renal failure, anuria, liver failure, diabetes mellitus (with confirmed or suspected chronic renal failure), diabetic nephropathy, pregnancy (1st trimester), metabolic acidosis, menstrual irregularities or breast enlargement. C caution ... AV blockade (the possibility of strengthening due to the development of hyperkalemia), decompensated cirrhosis of the liver, surgery, taking drugs that cause gynecomastia, local and general anesthetics, old age.

Forms of issue

tablets (0.025; 0.05), solution in ampoules (0.2% - 10 ml).

Spironolactone recipe

Rp .: Tab. Spironolactoni 0,025 No. 20

D.S. Inside, 2 tablets 3 times a day with edema syndrome

Diuretics occupy a large niche in the pharmaceutical industry. This is due to their fast and effective action, which is used in many fields of medicine.

Water retention in the body leads to edema, increased pressure, increased stress on the kidneys and heart.

For people with hypertension, increased content body fluids can lead to a hypertensive crisis.

In addition, excess water creates additional stress on the entire vascular system and subsequently can lead to venous expansion of the veins and the resulting complications. One of the most widely used diuretics is Spironolactone.

Diuretics are used to remove excess fluid from the body. This is necessary for many diseases accompanied by edematous syndrome, for example:

As adjunctive therapy Spironolactone is prescribed for:

• the use of cardiac glycosides to reduce their side effect - the removal of potassium cations from the body;
• myasthenia gravis.

Mode of application

Spironolactone is taken orally with water. The doctor sets the dosage and frequency of administration individually.

With constant intake, it is mandatory to monitor the indicators of kidney function and electrolyte composition blood plasma. The duration of treatment also depends on the course of the patient's illness and is selected individually. Most often, the drug is taken for a long time, several years.

With essential hypertension, the patient is prescribed 50-100 mg of the drug once, most often in the morning. You need to take Spironolactone for 2 weeks to get a full reaction of the body to the therapy. If necessary, the dose is changed gradually.

With hyperaldosteronism, the initial dose varies about 300-400 mg, but after receiving positive dynamics from the therapy, it is reduced to 25 mg per day.

With edema of a nephrological nature, the dosage of Spironolactone is 100-200 mg.

With heart failure chronic course the daily rate is 100-200 mg, then an effective maintenance dose is selected.

Release form

Manufacturers produce Spironolactone in tablets of various dosages and in capsules.

The dosage is 25, 50, 100 mg.

Composition

The active ingredient is spironolactone, which is an aldosterone antagonist. Aldosterone is a hormone of the adrenal cortex naturally produced in the human body.

A feature of aldosterone is to enhance the excretion of potassium ions from the body and increase the ability of tissues to retain water. As a result, a person develops edema, muscle weakness, and increases the load on the kidneys and heart.

Spironolatone has a diuretic and potassium-sparing effect, as a result of which it also exhibits a hypotensive effect. The diuretic effect occurs only 2-5 days after the start of treatment. The drug is 100% absorbed into the blood.

Drug interactions

When taken simultaneously with indomethacin, triamterene, potassium preparations or a group ACE inhibitors development of hyperkalemia is very likely.

Carbenoxolone reduces healing effect Spironolactone due to its antagonistic effect on sodium ions.

If anesthesia is required, it should be noted that Spironolactone can reduce sensitivity to norepinephrine.

Aspirin reduces the diuretic effect of the drug.

Spironolactone enhances the effect of other diuretics or drugs for high blood pressure, which requires a significant correction of their doses.

Weakens the effect of anticoagulants. Increases the toxicity of digoxin. When taken together with drugs of the NSAID group, renal function should be monitored.

Drinking with alcohol is absolutely contraindicated.

Glucocorticoid hormones, when taken simultaneously with Spironolactone, increase the diuretic effect, and also have a side effect - they increase the excretion of potassium.

Side effects

The complexity of the mechanism of action and interference with the hormonal system of the body determines the breadth of possible side effects that affect most body systems.

1. Arterial hypotension, arrhythmia, vascular lesions.
2. Anemia, thrombocytopenia.
3. Headache, paralysis, dizziness, lethargy.
4. Vomiting, gastritis, decreased appetite, diarrhea, bleeding, constipation, ulcers.
5. Disorders in the liver.
6. Renal failure.
7. Convulsions.
8. Metabolic disorders, porphyria, increased urea levels.
9. Decreased libido, hormonal imbalance, infertility, tumors.
10. Allergic rashes, erythema, eczema.
11. General weakness, fatigue.

Contraindications

The drug Spironolactone is contraindicated for use in diseases:

1. Hyperkalemia.
2. Addison's disease.
3. Hyponatremia.
4. Renal failure
5. Anuria.
6. Lactose metabolism disorders.
7. Lactation period.
8. Pregnancy.
9. Children under 3 years old.
10. Individual sensitivity.

If a patient has diabetes mellitus and hypercalcemia, Spironolactone is prescribed with caution. You should also consult about the possibility of using the drug in elderly patients and during surgery.

People whose work requires increased concentration, as well as drivers, should be careful when first taking Spironolactone.

Application during pregnancy

The drug passes the placental barrier very well, and also penetrates into breast milk, which is why its use during these periods is prohibited.

Storage conditions

Spironolactone must be stored at temperatures up to 25 degrees, in a dark, dry place.

Price

Price in Russia: 60 rubles (25 mg), 170 rubles (50 mg), 250 rubles (100 mg). The cost of the drug in Ukraine: 60 UAH (25 mg), 75 UAH (50 mg), 120 UAH (100 mg).

Analogs

Spironolactone analogues are: Veroshpiron, Aldacton, Spiriks, Spironol, Urakton.

In the fight against high blood pressure, blood will help effective drug prolonged action spironolactone. This medicine helps to remove excess fluid from the body (diuretic), but reduce the exit from the body of the extremely useful for the work of the heart and other vital internal organs potassium and magnesium. The benefits of its use are noticeable literally on the third day of taking this medication inside.

What the drug Spironolactone consists of

The main thing active substance- spironolactone. Additional constituents: monohydrate and calcium, as well as lactose and starch.

An effective medicine Spironolactone will be for such ailments as:

• Increased blood pressure blood (hypertension);
• When there is little potassium in the blood (this disease is called hypokalemia);
• Diseases of organs such as the adrenal glands, which cause an increase in blood pressure in the blood;
• Liver disease (cirrhosis), causing swelling of the legs;

Spironolactone belongs to three groups of drugs in pharmacology:

1. Diuretic medicines;
2. Medicines that have a beneficial effect on kidney function;
3. T. n. "Loop" means that remove excess fluid from the body.

The drug described by us is used both as monotherapy and together with the main treatment. It is prescribed for those who take cardiac glycosides.

How to take Spironolactone medicine

The most effective and useful, safe and effective instruction on the use of Spironolactone, a personal consultation with a doctor is considered. When a doctor prescribes a treatment regimen, he takes into account the existing diseases and medications taken.

Based on the symptoms of the disease, the doctor will dose the medicine. The dosage must be adhered to every day, unless a fractional use of the medication is prescribed. Slowly but surely, the dosage of the drug is increased (in order to achieve the maximum effect).

It is necessary to drink the described drug at the same time, taking it with meals. This approach will increase the efficiency of drug absorption into the body, and hence its speed. How long to be treated depends on the patient's condition and the degree of influence of the drug on the body.

How to take spironolactone for children

Minors (from 3 years old) can drink this medication only on the recommendation and prescription of the attending doctor, as a diuretic drug. The dose of the medicine per day is determined by the doctor. He does this knowing the child's body weight (calculated as 3 mg / kg per day) and the type of disease.

And adults and
minors who are taking this medication should follow a diet that excludes or restricts the intake of salty and fatty foods. Should be kept healthy image life, loading your body every day physical exercise doing exercises, walking, skiing, swimming.

It's important to know!

During drug treatment (and indeed) it is strictly forbidden to use alcoholic drinks and smoking. Otherwise, a state is possible in which the head is spinning, loss of consciousness. The dose of the drug Spironolactone or its analogs is determined individually, calculated based on the hormonal state of the patient and the type of disturbance in the exchange of water and salt in the body. An adult can take up to two hundred milligrams per day, it is extremely rare to prescribe a dose of up to four hundred milligrams per day. The course lasts 21 days, but if necessary, it can be repeated after 10 days.

Spironolactone and the post-conception period

In the first three months after conception, spironolactone should not be taken. If more than three months have passed after conception, taking the drug can only be allowed by a doctor and only as a last resort. Drinking this drug while breastfeeding is possible only when the child is transferred to artificial feeding as part of the refusal to breastfeed.

When you shouldn't drink spironolactone

Spironolactone should not be taken
simultaneously with other potassium-sparing diuretics, in order to avoid hyperkalemia (excess potassium in the body). Do not prescribe this medicine during such diseases and conditions:

• In the first three months of pregnancy;
• With renal failure;
• With Addison's disease, when the adrenal glands do not produce a certain hormone;
• If there is too much sodium, potassium and calcium in the body;
• At diabetes mellitus, accompanied by kidney pathology;
• If you are highly sensitive to this drug;
• The drug is not prescribed to children under the age of three years;
• It is contraindicated for mothers during breastfeeding.

Spironolactone is prescribed with caution to elderly patients. At the beginning of taking this medication, you cannot drive a car, since this drug affects the psychomotor reaction, lowers concentration.

Price

The price of this effective diuretic that lowers blood pressure is more than democratic - from 35 to 65 rubles (depending on the manufacturer). The dosage of spironolactone in one tablet is 25 mg or 100 mg. Packages are available in 20 and 30 tablets. Spironolactone is sold by prescription in Latin, in pharmacies.

Side effects:

1. Nausea;
2. Vomit;
3. Stomach ache;
4. Intestinal colic;
5. In case of overdose: dizziness and headache, lethargy, drowsiness;
6. In men, potency decreases;
7. Dysmenorrhea occurs in women;
8. In children side effect may manifest as hives (allergies in the form of a skin rash).

Spironolactone reduces the effectiveness of such medicines, like heparin, anticoagulants, mitotane, therefore, the simultaneous administration of these drugs is contraindicated.

Spironolactone: analogues of this drug

1. Spiriks;
2. Spironaxan;
3. Spironol;