Acid-alkaline balance is regulated by the systems of the body, which allows the latter to function normally. In the occurrence of acidosis, we are talking about the development of acid disorder towards the increase, which is the main symptom. Causes make it possible to determine the treatment. The metabolic acidosis is considered separately.
If the body increases the amount of acid, then the acidosis is developing. The reason is the insufficient removal of its body and oxidation. Also contribute to this intestinal disorders, starvation and feverish condition, which leads to formation in the urine of acetoxus acid, acetone, a comatose state in difficult cases.
Site site allocates several types of acidosis:
The most common type of acidosis is metabolic. With this form, a lot of acid is produced, which in very small quantities is displayed.
Metabolic acidosis is divided into types:
Metabolic acidosis manifests itself in the following symptoms:
This type of disease is diagnosed by analyzing blood to acid-alkaline balance. Treatment is aimed at eliminating the root cause. Sodium bicarbonate or sodium bicarbonate solution is intravenously introduced inside. So that there is no fatal outcome to which metabolic acidosis leads, it should be treated.
The lactic acidosis is another common disease in which there is a significant accumulation of lactic acid. Type A is marked with explicit tissue anoxy. Type in practically does not manifest itself.
Type A manifests itself more often. The type in manifests itself very quickly, the reasons for which scientists have not yet been reliably identified.
The type A of lactic acid acid is evolving due to:
The type in the lactic acid of acidosis develops due to the effects of pesticides, toxins and drugs.
Preservation of normal acid-alkaline balance It is an important factor as the absence of any infectious diseases. The main causes of the occurrence of acidosis are a lifestyle, a short-lived day of the day and improper nutrition. Also affects the ecology in which a person is abides.
Power plays a very important role. It seems that only acidic products contribute to the development of acidosis. In fact, acid in the body is the result of decay and oxidation of food elements. It is important that the kidneys and lungs worked well at the same time. The kidneys help in bringing non-volatile elements, and the lungs are volatile.
In addition, the organism should not be disturbed metabolism, and should also be absent chronic diseaseswhich provoke the latent flow of acidosis. These include tumors, allergic reactions, neurosis, rheumatism, inflammation of fabrics, etc.
Acidosis is often manifested by those symptoms that are expressed by the main disease. In a light form, it may not manifest at all. Sometimes it causes nausea, vomiting and fatigue. The heavy form is manifested in the impairment of the frequency and depth of breathing, heart abbreviations and stunning. Also, severe form is observed in the exchange of substances in the brain. This leads to constant drowsiness and coma.
The acute form of acidosis is recognized by the appearance of diarrhea and insufficient blood supply to tissues. Reducing blood flow provokes dehydration, shock, ostly blood loss and heart disease.
In children, acidosis can manifest itself due to the contest of the disease. This affects its development, leads to convulsions and injection of character.
The initial stage can be recognized by:
The aggravation of acidosis is accompanied by the appearance:
For sugar diabetes There is a smell of fruit in the mouth, among other signs.
With compensated form of disease, a change in sodium bicarbonate and coalic acid occurs. In decompensated form, there is a violation of the amount of acids and alkalis in the direction of excess one of the substances.
Quite often, acidosis arises against the background of non-spiratory causes. This is the accumulation of lactic acid, acetoxus or oxymaacean acid. The accumulation of lactic acid is often noted due to disorders in the work of the heart or lungs (oxygen starvation). The disease is also developing against the background of diarrhea. In this case, the body includes compensatory functions when the balance between acids and alkalis occurs.
Alkalosis and acidosis affect the work of the body. Breathing changes, the tone of vessels falls, the minute volume of the heart is reduced and arterial pressure. Violated aqueous I. electrolyte balance. Bones lose their hardness, gradually arise changes in the work of the heart.
Since the acidosis does not exhibit practically, the treatment is sent to eliminate the causes of its occurrence. However, the phenomenon itself is not ignored. Acidosis is treated with protein food with a slight form of its manifestation. From drugs prescribed sodium bicarbonate inside with a slight form or intravenously with severe. Calcium carbonate is prescribed if it is necessary to limit the amount of sodium and during hypocalcemia.
Metabolic acidosis is treated:
In pathologies, the rehydration salt, dimfosphone orally take orally.
The main emphasis is on proper nutrition. During treatment, the coffee and alcoholic beverages should be abandoned. Fruits, fats of plant origin, berries, fresh vegetables Accepted with white bread, pasta, animal fats. It is actively recommended to take decoction from rice to remove toxins, slags and other harmful elements.
Acidosis affects the functionality of the whole organism. If the acid-alkaline balance is broken, then other systems are violated. Mostly suffer from heart, lungs and kidneys. However, acidosis often indicates the development of other diseases that affect the violation of metabolic processes. The forecast is fully dependent on therapeutic measures to eliminate the cause and the most acidosis.
Life expectancy depends on how quickly a person treats acidosis. In some cases, we are talking about a fatal outcome, if the patient does not take any measures.
Acidosis is developing due to the accumulation of products that are formed when excessive oxidation of organic compounds, when the body does not have time to withdraw them in a timely manner. This is called as internal reasonsand external. Internal factors talk about pathologies of functions of various systemswhich lead to metabolic disorders and accumulation of metabolites formed during oxidation. External reasons include, first of all, inhalation of the air mixture in which is observed increased content carbon dioxide. The hardest complications of acidosis become a shock or coma state. Extremely possible outcome is also possible.
Regardless of the etiological factor, the acidotic state leads to serious complications. These include:
There are several criteria for which it is possible to distinguish the types of acidotic states.
If the acidity indicator reaches minimally permissible values \u200b\u200b(below 7.24), this can lead to denaturation of proteins in the body tissues, the destruction of the cell wall, cell death, pathological changes in the functioning of enzymes, which in the aggregate leads to irreparable consequences up to death.
Acidosis is a pathological condition and is not classified as a separate disease. It arises as a result of action on the body of etiological factors to which include:
The symptoms of this disease are quite difficult to differentiate from the signs of other pathologies. The manifestations of the main symptoms include:
Light forms of pathology may not cause the development of a clear clinical picture.
The doctor also examines an inspection and collection of anaman data, which can help in establishing the cause of the pathological condition.
Since the acidosis is caused by the pathologies of many systems, then for its treatment, first of all, it is necessary to determine the main reason and to send efforts to eliminate it. That is, therapeutic measures are taken with respect to the main disease.
In metabolic acidosis therapy should include introduction of the missing fluid by intravenous infusion. Heavy forms of the acidotic state should be relocated to the appointment of medicines that contain sodium bicarbonate. Infusion and drinking forms of this drug are able to increase the level of the hydrogen indicator to the required values. Also, bicarbonate must be added to glucose infusions or physiological solution of sodium chloride, the proportions are determined by the degree of metabolic disorders.
In the manifestation of pronounced signs of a painful state, symptomatic therapy may be appointed. If the acidotic pathology arose as a result of entering into the body of toxic substances, it is necessary to take measures to eliminate them. Sometimes dialysis may be required.
It is worth noting that it is important to cure the main pathology, which caused the development of acidosis.
If it is not eliminated by its etiological factors, the acidotic state may occur again, which destructively affects the functioning of all systems internal organs. Therefore, it is necessary not to simply bring the indicator of the pH of the medium, but also to find out and adjust the cause that caused an increase in acidity inside the body. This will avoid unwanted consequences, which include heavy pathologies - shock, comormed states, as well as fatal outcome.
The emergence and development of acidosis can be prevented if you lead correct image Life. Also should not be allowed situations under which disorders of metabolic processes inside the body are possible. Reduce the likelihood of an acidotic state, if you follow a series of measures:
For timely diagnosis and appointing correct therapeutic measures outcome prognosis of acidosis may be favorable. In cases of a launched state, a number of serious complications may occur, which include shocks and to whom. In rare cases, acidosis leads to a fatal outcome. Therefore, it is important to carry out the necessary diagnostic events, Repeated medical Helpwhich should include bringing the pH to normal.
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Under the medical term "acidosis" implies the condition of the human body, in which the acid-alkaline balance is broken.
The disorder of acid-alkaline equilibrium occurs as a result of insufficient oxidation and removal of organic acids. Generally, W. healthy man These products are removed from the body quickly. In some diseases and states (for example, during pregnancy, with intestinal disorders, starvation, febrile diseases, etc.) they are removed very slowly. In light cases, this is manifested by the appearance in the urine of acetone and acettoacetic acid (such a state is called acetionary), and in heavy (for example, with diabetes mellitus) leads to a coma, shock and even the death of a person.
Thus, the causes of acidosis, or rather, factors that accompany the development of this state may be:
It is worth noting that it is not always possible to establish the cause of acidosis.
By origin, acidosis is divided into:
In turn, irregular acidosis classified on:
By the level of the pH (at a rate of 7.25-7.44), acidosis is divided into:
In the case when the pH level in the body reaches extremely low (less than 7.24) indicators (actually, as extremely high), denaturation of proteins (i.e., the loss of their natural properties), and the function of enzymes is reduced, cell destruction occurs - It can lead to the death of the body.
Acidosis can cause such critical states as:
The symptoms of acidosis are severely differentiated from the signs of various diseases, and in light shapes, they are not associated with a disorder of acid-alkaline equilibrium.
The symptoms of acidosis in a light form can be:
More heavy conditions Acidoza may be accompanied by:
Heavy acidosis can lead to circular shock developing as a result of disorders of myocardial reductions and the reaction of peripheral vessels on catecholamines.
As mentioned above, the symptoms of acidosis are not specific. In addition, they are very often disguised by signs of the underlying disease, so the diagnosis is not always able to install immediately.
For accurate diagnosis, patients conduct the following studies:
The last two studies allow you to determine not only the availability of acidosis in humans, but also its type (respiratory or metabolic).
In order to determine the cause of acidosis, a number of additional research may be needed.
Due to the fact that the described condition is the result of the violation of the functioning of the organism systems, the purpose of the treatment of acidosis is to eliminate the factors that have become a starting mechanism. In particular, we are talking about the treatment of basic diseases, pathological conditions or dysfunctions, which provoked a shift of acid-alkaline equilibrium of the body.
The correction of heavy forms of acidosis suggests:
The targeted correction of the acid-alkaline state by administering solutions of buffers is carried out only at a pH level of less than 7.25 (with decomposed acidosis).
The symptomatic treatment of acidosis implies abundant drinking, intake of soda, as well as the elimination of related signs (malaise, nausea, arrhythmias, increased pressure etc.). In case of poisoning, drugs are prescribed toxic substances From the body, dialysis is carried out in severe cases.
Treatment of acidosis in children is similar to therapy of this state in an adult.
Acidosis I.
Acidosis (acidosis; lat. Acidus sour + -SIS)
one of the forms of disorders of the acid-alkali equilibrium of the body; It is characterized by an absolute or relative excess of acids, i.e. substances that give hydrogen ions (protons), in relation to the grounds that attach them. Acidosis can be compensated and noncompensated depending on the value of the pH - hydrogen indicator of the biological medium (usually blood) expressing the concentration of hydrogen ions. With compensated acid acidosis, the blood pH is shifted to the lower boundary of the physiological norm (7.35). With a more pronounced shift in the acidic side (pH of less than 7.35), acidosis is considered noncompensated. Such a shift is due to a significant excess of acids and the insufficiency of physico-chemical and physiological mechanisms for the regulation of acid-alkaline equilibrium. (Acid-alkaline equilibrium)
By origin A. may be gas, negascin and mixed. Gas A. arises due to alveolar hypoventilation (insufficient removal of CO 2 from the body) or as a result of inhalation of air or gas mixtures containing elevated carbon dioxide concentrations. At the same time, carbon dioxide (RSO 2) in arterial blood exceeds the maximum values \u200b\u200bof the norm (45 mm RT. Art.), i.e. occurs . Negazova A. is characterized by an excess of non-volatile acids, a primary decrease in the content of bicarbonate in the blood and the absence of hypercaps. Its main forms are metabolic, excretory and acidosis. Metabolic A. arises due to the accumulation of excess acidic products in tissues, insufficient binding or destruction; With increasing products of ketone (), lactic acid (lactate-acidosis) and other organic acids. develops most often in diabetes mellitus, as well as in starvation (especially carbohydrate), high fever, severe insulin hypoglycemia, with some types of anesthesia, alcoholic intoxication, hypoxia, extensive inflammatory processes, injuries, burns, etc. Lactat-acidosis is most common. A short-term lactate-acidosis occurs with enhanced muscle work, especially in incredible people, when the production of lactic acid increases and its absence of its oxidation occurs due to the relative oxygen deficiency. Long-term lactate acidosis is observed in severe liver lesions (, toxic), decompensation of cardiac activity, as well as with a decrease in oxygen flow in due to the insufficiency of external respiration and with other forms of oxygen starvation. In most cases, metabolic A. develops as a result of an excess in the body of several acidic products. Selective A. As a result of a decrease in the elimination of non-volatile acids, the kidney diseases (for example, in chronic diffuse glomerulonephritis), resulting in the difficulty of removing acid phosphates, organic acids. Enhanced derivation of sodium ions caused by the development of renal A., is observed in the conditions of braking of acido- and ammoniogenesis processes, for example, long use sulfanimide drugs, some diuretic products. The excretory A. (gastroenterical form) can develop with an increased loss of bases through the gastrointestinal tract, for example, with diarrhea, a stubborn vythe of the alkaline sideline, as well as with a long-enhanced salivation. A. It comes to introduce a large amount of acidic compounds into the body, incl. Some drugs. The development of mixed forms A. (a combination of gas and various types of negotiane A.) is due, in particular, by the fact that CO 2 diffuses through alveolokapillary membranes by about 25 times easier than 2. Therefore, the difficulty of discharge CO 2 from the body due to insufficient gas exchange in the lungs is accompanied by a decrease in blood oxygenation and, consequently, the development of oxygen starvation with the subsequent accumulation of unsophisticated interstitial exchange products (mainly lactic acid). Such forms of A. are observed in the pathology of cardiovascular or respiratory systems. Moderate compensated by A. flows almost asymptomatic and recognized by studying buffer blood systems, as well as urine composition. At deepening A. One of the first clinical symptoms It is reinforced, which then goes into a sharp breath, pathological forms of breathing. The noncompensated A. is characterized by significant disorders of the functions of the Ts.S., the cardiovascular system, the gastrointestinal tract, and other A. leads to an increase in the content of catecholamines in the blood, so when it appears, the increase in cardiac activity, the increase in pulse, increase minute volume of blood, rise. As I deemed, A. decreases adrenoreceptors, and despite the increased content of catecholamines in the blood, cardiac activity is depressing, hell drops. In this case, often arise different kinds Heart arrhythmias, right up to ventricular fibrillation. In addition, A. leads to a sharp strengthening of vagus effects, causing, increasing the secretion of bronchial and digestive glands; Often there are diarrhea. With all forms of A. The dissociation curve of oxymemoglobin is shifted to the right, i.e. The affinity of hemoglobin to oxygen and its oxygenation in the lungs are reduced. For the correction of subcompensated metabolic A. In children (pH 7.35-7-7.30), hydrochloride of caocarboxylase, riboflavin mononucleotide, is used, solution nicotinic acid, glutamic acid solution, sodium bicarbonate. Sodium bicarbonate is part of the oral rehydration salt proposed for oral rehydration during acute gastrointestinal diseases. Children over 6-8 years old can be prescribed a solution of dimphosphon; Used in acute and exacerbation of chronic bronchology pathology, diabetes mellitus, ricket-like diseases, etc. Dimphosbon can cause dyspeptic disorders. Treatment of heavy, noncompensated metabolic A. (pH 7.29 and lower) requires compulsory infusion of infusion lesheluoric therapy (usually a solution of sodium hydrocarbonate, which is determined by the formula formula). In order to limit sodium intake, trisamine is used to limit sodium hydrocarbonate. Compared with sodium bicarbonate, trisamine is a good diuretic, has a stronger alkalizing effect and reduces the level of RSO 2. It is shown at a pH of about 7.0. However, newborns, especially in premature, it is not recommended to apply it, because It oppresses his breath, causes an intracellular obscure effect, predisposes to the emergence of hypoglycemia and hypokalemia. It should not be applied to children as a base of sodium lactate, which was previously widely promoted as an integral part of the Darrow mixture. For the treatment of lactate-acidosis, dichlorocetate, activating the enzyme complex of pyruvate dehydrogenase, as well as liquipoic acid preparations, is used. When appropriate antiacidotic funds, strict control of acid-alkaline equilibrium indicators with the simultaneous definition of the ionogram is required. With metabolic A., arising from rapidly developing pathological processes, the danger of complications from the obsching solutions is greater than the benefit of the rapid normalization of blood pH. First of all, it concerns young children. So, intravenous administration Cocarboxylase having a soft leaning action can cause a sudden stopping of the heart. Hypertensive solutions of sodium bicarbonate, leading to hypernatremia and blood plasma hyperosmolarity, can contribute to the development of intracranial hemorrhages, especially in premature. The inkjet administration of these solutions can cause a metabolic, as a result of which the content of ionized calcium in the blood decreases with subsequent Tetania and apnea. Therefore, newborns are expediently corrected by A. Sodium bicarbonate solution. Gas A. Treatment is carried out on the principles of treatment of respiratory failure (respiratory failure) .
With a timely manner and systematically conducting treatment, you can ensure normal development of the child. the shape of the disorder of acid-alkaline equilibrium in the body, characterized by a shift of the ratio between anions of acids and base cations towards an increase in anions. Acidosis excretory (a. Excretoria) - A. resulting from significant amounts of foundations or disruption of non-violating acids; to A. in. Related kidney A, and Gastroenterst A.
The body is a very complex system consisting of various parts: organs, tissues, cells. And if a failure occurred at some level, the functioning of the entire body will certainly be impaired.
For example, if the number of acids (they are certainly present in tissues, blood) will increase, then the acidosis will arise. And what are his symptoms? And how should be held effective treatment?
Acidosis is not an independent disease, but a condition that occurs as a result of a disorder of the acid-alkaline balance of the body.
Each organism contains acids, they are necessary for its operation. And in the normal state, these most acids should be output, which provides balance.
But if this for some reason does not happen, they will accumulate in the blood, in the urine and even in some organs. This will certainly tell the alarming symptoms. It is worth noting that treatment should be timely, since strong oxidation is not normal, it can lead to sad consequences.
Several varieties of such a disease are distinguished. For example, if you take a condition for the development mechanism, the following types can be distinguished:
There is also a mixed form at which accumulating and carbon dioxide, and non-volatile acids.
Uncredit acidosis can also be classified:
Depending on the concentration of acids (it is determined by the level of pH) allocate:
Such a condition cannot develop unprepaid. There are many negative factors that can provoke an acid-alkaline balance disorders:
Symptoms of such a disease like acidosis light form Diseases or at the initial stage can not manifest itself and do not disturb. And sometimes they are expressed only in the signs of the underlying disease, which led to the accumulation of acids and the development of this state.
But the manifestations are important to recognize on time to begin treatment and avoid heavy consequences, one of which is coma, and later death.
That's what symptoms should alert:
It is possible to identify acidosis using blood and urine tests, as their composition will certainly change.
With such a disease, such as acidosis, immediate treatment is required, since in difficult cases there is a fatal outcome. So if there is alarming symptoms, immediately consult a doctor.
Here are basic measures:
Acidosis is curable if measures are timely. Health to you!