Gross formula

Pharmacological group of substance Platifillain

Nonological Classification (ICD-10)

CAS code

Characteristics of the substance Platifillain

Alkaloid of a crossover (bribant or broad-sized).

White crystalline bitter taste powder, easily soluble in water (1: 5 in hot, 1:10 in cold), weakly soluble in alcohol. pH 0.2% solution - 3.6-4.0.

Pharmacology

Blocks M-cholinoreceptors and has a direct relaxing effect on smooth muscles. Expands the vessels, lowers the tone of smooth muscles bile ducts And the gallbladder, bronchi, causes mydriasis.

Quickly and fully absorbed into the gastrointestinal tract. Easily passes through histohematic barriers, cellular and synaptic membranes. With the introduction of large doses accumulates in the tissues of the CNS in significant concentrations. I am excreted by urinary I. digestive systems. With proper assignment (dose, intervals between receptions) does not cumulate.

Application of a substance Platifillain

Smooth muscle spasms when peptic disease Stomach I. duodenal gut, intestinal, hepatic and kidney colikah, bronchial asthma, hypertonicity, angina, spasms of brain vessels, pain syndrome with pancreatitis, pancreatic coma, dyskinesia of biliary tract, reflux-esophagitis, bradyritium poisoning, acetone, boric acid, strong acids, arsenic, reserpine, diarrhea (imperative urge), in ophthalmological practice - to expand the pupil in diagnostic and therapeutic purposes.

Contraindications

Glaucoma, lack of liver and kidney function, paralytic obstruction or intestinal atony, ulcerative colitis, miastic.

Side effects of the substance Platifillain

Dry mouth, expansion of pupils, accommodation violation, heartbeat, decreased blood pressure, shortness of breath, intestinal atony, urine delay, excitation, cramps.

Interaction

Increases the duration of the hypnotic effect of the phenobarbital and sodium etame blocks the effects of the prozerban, increases - administered inside H 2-gestamolithics, digoxin and riboflavin (slows down the peristaltics and improves suction). Adrenomimetics (reinforce mydriasis) and nitrates will potenize the increase intraocular pressure, amizil, diphenhydramine, tricyclic antidepressants, chinidine sulfate, novocainamide, dizopiramide, isoniazide, Mao inhibitors, Midtenan - anticholinergic activity. Eliminates bradycardia, nausea and vomiting caused by morphine, bradycardia when receiving verapamila.

Overdose

Symptoms: dry mouth, voices fucking, swallowing disruption, expansion of pupils with a lack of reaction to light, tachycardia, hyperthermia, redness of the skin, excitation of the CNS, followed by oppression, violation of consciousness, hallucinations, convulsive syndrome, respiratory failure, intestinal paresis, acute urine delay.

Platiminal hydrothatrate (shape - solution) (pharmacological group - preparations for treatment functional disorders From the head of the gastrointestinal). The instructions for use allocate the following drug features:

• For sale only by prescription doctor
• During pregnancy: contraindicated
• When breastfeeding: contraindicated
• IN childhood: carefully
• With liver function violations: With caution
• With a violation of the kidney function: with caution

Packaging

Structure

One ampoule contains 1 ml of a hydrotathe platochillin solution (2 mg), as well as distilled water.

Pharmacopoeia (arch medical standards) Determines that the recipe for latin Formulated as: Platyphyllini HydrotartRas Solution Pro Injectionibus 0.2%.

Form release

The solution is intended for subcutaneous administration In the type of injection in the package:

• 10 ampoules in the cardboard box;
• 5 ampoules in a cell contour pack (2) in a carton box.

pharmachologic effect

M-cholinolitic, vasodilating (vasodilator) and soothing effect.

Pharmacodynamics and pharmacokinetics

Platifiline Hydrothatrate is characterized by a cholinitic effect: blocking M-choline receptors, turns them into insensitive to acetylcholine of the form. Thanks to the direct myotropic antispasmodic effect on the smooth muscles of the intestines, the biliary paths, bronchi and eyes are considered by the mechanism of exposure to the papaverine actuator. In addition, it has a weakly pronounced direct depressing effect on the smooth muscles of vessels, soothing the effect of the CNS, especially on the Vasomotor Center, exerting vasodilatory and hypotonic effects.

Platiminal hydrothatrate is well absorbed from the subcutaneous layer of epidermis. However, the introduction of large doses causes a cumulation in the TsNS tissues in a significant concentration. It is derived by urinary, as well as the digestive system.

Indications for use

Used with functional disorders of the digestive tract, including in the spasome of the smooth muscles of the stomach and duodenal ulcers, colic (intestinal, hepatic and kidney).

In addition, the remedy is effective with diseases such as cholecystitis, bronchial asthma, hypertension or angina, bradycardia with arrhythmia, spasm of brain vessels, diarrhea, painfulness In case of pancreatitis, dyskinesia of biliary tract, inflammation of the mucosa of the esophagus.

It is used in poisoning with substances such as acetone, boric acid, strong acids, arsenic, reserpine.

Used in diagnostic ophthalmology (research of the eyeboard and the definition of eye refraction) and in the treatment of keratitis, irita, iridocyclitis, various eye injuries, in rare cases, is used to expand the pupil.

Contraindications

Not recommended application when glaucoma, various degrees Lack of liver or kidney function, ulcerative colitis, myasthenia, paralytic obstruction or intestinal atony. Contraindication is increased sensitivity to the components of the drug components.

Side effects

The most likely are the following adverse reactions When applying high doses: dry mouth, expansion of pupils, intestinal atony, decreased blood pressure or tachycardia, accommodation violation, dizziness, shortness of breath, acute urine delay, headaches, excitation of CNS and convulsions.

Instructions for use (method and dosage)

Apply inside, parenterally (subcutaneously, intravenously), rectally or locally.

Platiminal hydrothatrate intramuscularly used if necessary - is assigned and adjusted by the attending physician, which is responsible for this purpose. The dose is determined depending on the symptoms and the degree of the disease, the path of administration and age of the patient.

Usually platifillin hydrotatherate are prescribed in treatment:

• The relief of acute ulcerative pain, intestinal, hepatic or kidney colic, which prolonged bouts of bronchial asthma, cerebral and peripheral angiospams adults - 1-2 ml 1 or 2 times a day.
• how antispasmodic Adults - 1 ml daily for one month. The maximum one-time dose for an adult subcutaneously - 10 mg per day no more than 30 mg.

Overdose

Clinical Picture of Overdose Platimin Hydrottom:

• dry mouth;
• an increase in heart rate and decreased blood pressure;
• extended pupils and lack of reactions to light;
• accommodation paresis;
• acute difficulty of urination;
• intestinal paresis;
• convulsions;
• dyspnea;
• hyperthermia and redness of the skin;
• the excitation of the CNS with its subsequent oppression;
• various violation of consciousness, including hallucinations;
• respiratory failure.

The activities carried out in this case: forced diuresis, the use of enzyme inhibitors - Holinesterase (for example, Fizostigmin, Galanamin or Prezero) to weaken the intestinal paresis and reduce tachycardia.

If the excitation of the central nervous system is moderate, and the convulsions are not expressed, then it is recommended to use magnesium sulfate, in heavy conditions - Oxybutirate sodium, hydrocerapy, conduct artificial ventilation lungs.

Interaction

• Platifin hydrothatrate is able to extend the hypnotic effect of the phenobarbital, etame of sodium, magnesium sulfate;
• capable of blocking prozer;
• may increase the effect of H2-histamine blockers, digoxin and riboflavin;
• can enhance mydriasis with adrenomimetics and nitrates, increasing intraocular pressure;
• compatible with caffeine in spasms of brain vessels;
• compatible with cordamine and diaphillin;
• with morphine eliminates bradycardia, nausea, vomiting;
• with Verapamil eliminates bradycardia.

Terms of sale

On prescription.

Storage conditions

In the place protected from light and inaccessible to children.

Shelf life

Five years.

Analogs

• Platifillin;
• Infraak;
• Enterosphazmil.

Reviews about Platifillina Hydrothatrate

Numerous reviews about the preparation talk about its effectiveness and accessibility, but many are interested in the complexity of the application in terms of interaction with other drugs, the method of administration and dosage. All this should be strictly monitored and adjusted by the attending physician who wrote as a recipe.

Price where buy

10 ampoules of platifilline hydrotatherate can be purchased almost in any pharmacy at a price of 45-70 rubles.

Reviews

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Platifillain Platifillain

Active substance

›› Platyphylline (Platyphylline)

Latin name

Pharmacological groups: M-cholinolics
›› Miotropic spasmolitics

Nonological Classification (ICD-10)

Composition and form of release

1 ampoule with 1 ml of injection solution contains platifylin hydrotatherate 2 mg; In a carton box 10 pcs.

Characteristic

Vinnocamean alkaloid salt contained in a cross.

pharmachologic effect

pharmachologic effect - antispasmodic, vasodilative, sedative. Inhibits cholinoreactive systems that ensure excitation transmission from the end parasympathetic nerves The executive bodies have a soothing effect on vascular centers.

Indications

Spasm smooth musculature internal organs, ulcerative ulcer of the stomach and duodenum, bronchial asthma, hypertension.

Contraindications

Glaucoma, liver renal failure.

Side effects

Dry mouth, accommodation paresis, tachycardia, difficulty urination.

Method of application and dose

P / k - 2-4 mg 3 times a day. The highest one-time dose is 10 mg, daily - 30 mg.

Shelf life

Storage conditions

List a.: In the place protected from light, at a temperature not higher than 30 ° C. (in tightly closed packaging).

* * *

Platifillin (PLATYPHYLLINUM). Alkaloid Platifillain is contained in a diagonal diagram, or broad-sin. Senecio Platyphylus D.C., Sez. COMPOSITAE). Refers to the Heliotridan derivative (1-methyl pyrrolized poster). In medical practice, platform hydrotatrate (PLATYPHYL-LINI HYDROTARTRAS) is used. Synonym: Platyphyllinum Hydrotartaricum. White crystalline powder of bitter taste. Easily soluble in water (1: 5 in hot, 1:10 in cold), very little - in alcohol; pH 0.2% solution 3.6 - 4.0. Solutions are sterilized at +100 "C for 30 minutes. Platifillain has a cholinolitical effect. By affecting peripheral cholinoreactive systems is close to atropyne. Less active than atropine, but at the corresponding doses is not inferior in action atropine; better is transferred. Stronger than Atropine , Inhibits cholinoreactive systems of vegetative nerve nodes. At the central nervous system, especially on vascular centers, has a soothing effect. It also has spasmolytic (papaverine) properties. Assign in the spasms of smooth muscles of organs abdominal cavity, ulcerative ulcer of the stomach and duodenum, bronchial asthma; The drug reduces spasms blood vessels (for hypertensive disease, angina), spasms of brain vessels. In ophthalmologic practice is used to expand the pupil. Comparatively with atropine, the effect on the accommodation is noticeable. The effect on the pupil is less long than the action of atropine and homatropine (see). To relieve acute ulcerative pains, as well as intestinal, hepatic, renal colic, platifillain is administered under the skin of 1 -2 ml of 0.2% solution. For exchange rate treatment (10 - 15 - 2O days), they are prescribed inside (before meals) at 0.00s - 0.005 g or 10 - 15 drops of 0.5% solution 2 - 3 times a day or administered under the skin 1 - 2 ml 0.2% solution. The drug can also be prescribed in the candles of 0.01 g 2 times a day or in microclism of 20 drops of 0.5 - 1% solution 2 - 3 times a day. In the eye practice, 1% solution for diagnostic purposes and 2% solution for therapeutic purposes are used. Children are prescribed 0.0002 g (0.2 mg) - 0.003 g (3 mg) on \u200b\u200breception depending on age. In s and e d o z s for adults inside and under the skin: one-time 0.01 g, daily 0.03 g. The overdose of platificity can cause the same phenomena as an overdose of atropine (dry mouth, heartbeat, the expansion of pupils, The excitation of the CNS, etc.). Contraindicated in glaucoma, as well as organic diseases Liver and kidney. Forms of release: powder; Tablets at 0.005 g (5 mg); 0.2% solution in ampoules 1 ml. Storage: List A. In a well-visited container. RP.: TAB. Platyphyllini Hydrotartratis 0,005 N. 6 D.S. 1 tablet 2 - 3 times a day RP.: Platyphyllini Hydrotartratis 0.005 Papaverini Hydrochloridi 0.02 D.T.D. N. 10 IN TAB. S. 1 tablet 2 - 3 times a day RP.: Platyphyllini Hydrotartratis Oh, 003 Paravini Hydrochloridi 0.03 THEBROMINI 0.25 D.T.D. N. 10 IN TAB. S. 1 tablet 2 - 3 times a day (with angiospasm) RR: SOL. PLTUPHOULINI HOUDROTARTRATIS 0.2% 1 ML D.T.D. N. 10 in AMPULL. S. subcutaneously 1 ml 2 times a day RR.: SOL. РЛАТURHULLINI HOUDROTARTRATIS 0.5% 20 ML D.S. Inside 10 drops 2 times a day RR: SOL. РЛАТURHULLINI HOUDROTARTRATIS 1% (2%) 10 ML D.S. Eye drops (To expand the pupil) Tepafillain tablets (Tobulletae "Therarhulinum"). Ingredients: Platiminal hydrothatrate 0.003 g, hydrochloride papaverine and phenobarbital 0.03 g, theobromin 0.25 spasmolytic, cholinolitical, vasodilator. Assign 1 tablet 2 - 3 times a day (List a). Tablets "Palefin" (Tabulettae "Relufinum"). Ingredients: Platiminal hydrothatrate 0.005 g, phenobarbital and hydrochloride papaverine for 0.12 g. Antispasmodic and cholinolitic agent. Assign 1 tablet 2 3 times a day (List a).

. 2005 .

Watch what is "Platifillain" in other dictionaries:

SUT., Number of synonyms: 1 Alkaloid (862) Dictionary of Synonyms ASIS. V.N. Trishin. 2013 ... Synonym dictionary

- (Lat. Platyphyllinum, applied in the form of hydrotathe lat. Platyphyllini HydrotartRas) alkaloid, anticholinergic agent, muscarinic receptor antagonist. Contents 1 Getting ... Wikipedia

Drug from a group of cholinolithic agents (see cholinolitic agents); Alcaloid contained in the SEENCIO Platyphylloides) and Rabbit PolyphylLoDes (Senecio Platyphylus). By… … Great Soviet Encyclopedia

See pyrrolized alkaloids ... Chemical encyclopedia

platifillain - Platifill Ying, and ... Russian spelling dictionary

Platifillain - (Platyphyllinum), the alkaloid contained in the SEENCIO PlatyphylLus (Senecio Platyphylus) family of comprehensive. Apply P. hydrotartrate (Platyphyllini HydrotartRas; FC, list A) - cholinolitical (antispasmodic, mydritic) ... ... Veterinary Encyclopedic Dictionary

Active substance \u003e\u003e Papaverine + Platyphyline (Papaverine + Platyphylline) Latin name Tablettae Platyphyllini, Papaverini Mez ATH: \u003e\u003e A03AD51 Papaverin in combination with other drugs Pharmacological group: Antispasmodics ... ... Dictionary of medical preparations

Platifillin (PLATYPHYLLINUM). Alkaloid Platifillain is contained in a diagonal diagram, or broad-sin. Senecio Platyphylus D.C., Sez. COMPOSITAE). Refers to the Heliotridan derivative ... ... Dictionary of medical preparations

Contain pyrrolizidine residue in the molecule. Detected in 14 families, as well as in animal organisms. Naib We are rich in these alkaloids of clans of clans Buzotnoe (Ligularia) and a cross series (Senecio) of families of complex color, Cynoklone (Cynoglossum), ... ... Chemical encyclopedia

Slavic Slavnik - SoneCio Platiphyllus (Bied) D.C. Family complex color. A perennial grassy plant with a height of 50 250 cm. Rhizome is long, creeping, grayly brown, with transverse scars from fallen leaves, with a wide loose core inside or hollow, ... ... Encyclopedia medicinal plants

Tradename:Platifillain

International UnPatented Name:

Chemical rational name:
3-ethylidene-6-hydroxy-5,6-dimethylpergidro-1,8-dioxacyclodododine pyrrolizin-2,7-dion (in the form of hydrotathetrate)

Dosage form:

Structure
In 1 ml of the solution contains:
Active substance: Platiminal hydrothatrate - 2 mg
Ancillary: water for injections.

Description: Transparent colorless liquid.

Pharmacotherapeutic Group:

ATX code: AOCA

pharmachologic effect
Blocator M-cholinoreceptors. It has a myotropic antispasmodic and weak sedative effect. Reduces the tone of smooth muscles gastrointestinal tract (Gastrointestinal tract), bronchi. Reduces the secretion of salivary, tear, bronchial, sweat glands. Expands the pupil, causes moderately pronounced accommodation paralysis and an increase in intraocular pressure.

Indications for use
Ulcerative disease of the stomach and duodenum; to relieve seizures of spastic pains (intestinal, hepatic, renal colic); as auxiliary means at bronchospasm in patients bronchial asthma.

Contraindications
Hypersensitivity, closed-coronal glaucoma, cachexia, pronounced atherosclerosis, heart failure II-III Art., Arrhythmia, Tachycardia; hyperplasia prostatic gland; liver and / or renal failure; Pyloroduodenal stenosis, a diaphragmal hernia in combination with reflux-esophagitis, paralytic ileus, intestinal atony, bleeding from the gastrointestinal tract, megolone complicated with ulcerative colitis; Elderly and senile age.

Carefully - pregnancy; lactation period; ischemic disease hearts; Mitral stenosis; arterial hypertension; acute bleeding; thyrotoxicosis; increased temperature bodies; GCC diseases accompanied by obstruction (including ahalasia and stenosis of the gatekeeper); diseases with increased intraocular pressure (including open-hearted glaucoma); age older than 40 years (danger of manifestation of undiagnosed glaucoma); nonspecific ulcerative colitis; dry mouth; chronic diseases lungs, especially in children younger age and weakened patients; Miasti; Vegetative (autonomous) neuropathy (urine delay and accommodation paralysis may increase); urine delay or predisposition to it or disease accompanied by obstruction urinary tract; Gestosis; Dauna disease; childish cerebral paralysis.

Method of application and dose
To relieve acute pain in the ulcer of the stomach and duodenum, intestinal, hepatic and renal colic, the preparation is administered under the skin of 2-4 mg (1-2 ml of 0.2% solution). For exchange rate treatment (10-20 days), they are administered subcutaneously at 2-4 mg 2-3 times a day.
The highest dose for adults: one-time - 10 mg, daily - 30 mg.
One-time doses For children per 1 kg of body weight: newborn and breast -0.035 mg / kg (0.0175 ml / kg), 1-5 years - 0.03 mg / kg (0.015 ml / kg), 6-10 years - 0.025 mg / kg (0.0125 ml / kg), 11-14 years - 0.02 mg / kg (0.01 ml / kg).
Higher daily doses for children: newborn and breast - 0.07 mg / kg, 1-5 years -0.06 mg / kg, 6-10 years - 0.05 mg / kg, 11-14 years - 0.04 mg / kg.

Side effect
Dry mouth, thirst, reduction of blood pressure, tachycardia, mydriasis, accommodation paralysis, intestinal atony, dizziness, headache, photophobia, convulsions; urine delay; acute psychosis (in high doses); Atelectas lung.

Overdose
Symptoms: paralytic intestinal obstruction, acute urine delay (in patients with prostate adenoma), accommodation paralysis, increasing intraocular pressure; dryness mucous membrane sheath, nose, throat, difficulty swallowing, speech, mydriasis (up to the complete disappearance of iris), tremor, cramps, hyperthermia, excitement, depression of central nervous system, Suppression of the activity of respiratory and vascular centers.
Treatment: Forced diuresis, parenteral administration of chicnosis and anticholinesterase agents. With hyperthermia - wet wipes, antipyretic agents; when excited - in / in the introduction of sodium thiopental or rectal chlorine; at mydriase - locally, in the form eye drops Phosphall, Fizostigmin, Pilocarpine. In the event of the development of the bosome attack, a 1% pylocarpine solution is instilled in a conjunctival bag through each hour of 2 cap and p / k - 1 ml of 0.05% sosmene solution 3-4 times a day.

Interaction with other medicines
Enhances the sedative I. sleeping action Phenobarbital, sodium etamine, magnesium sulfate. Other M-cholinoblockers, Amantadine, Haloperidol, Phenothiazine, Monoaminoxidase inhibitors (MAO), tricyclic antidepressants, some antihistamines increase the risk of development side Effects. Antagonism - with anticholinesterase preparations. Morphine enhances the depressing effect on the cardiovascular system; Mao inhibitors are positive chrono- and bathemopic effects; Cardiac glycosides - a positive battle effect; County, Novocainamide -Holino-blocking effect. With pains associated with smooth muscle spasms, the action enhances analgesics, sedatives, tranquilizers; With vascular spasms - hypotensive and sedatives.

special instructions
During the treatment period, it is necessary to refrain from potentially dangerous species Activities requiring increased attention.

Form release
Solution for subcutaneous administration 2 mg / ml in 1 ml ampoules. 10 ampoules with the instructions for use, a knife with an ampumen or scarifier in a pack of cardboard. When packing ampoules with notches, rings and dots to open the knife or scarifier ampulle do not invest.

Shelf life
5 years. Do not use the expiration date specified on the package.

Storage conditions
List A. In the place protected from light and inaccessible to children at temperatures from 10 to 25 ° C.

Conditions of vacation from pharmacies
On prescription.

Manufacturer / organization accepting complaints:
FSUE "NPO" Microgen ", Russia 115088, Moscow, ul. 1st Dubrovskaya, d. 15.
Address of production: 614089, Perm, ul. Fraternal, d. 177.

Publication date: 26-11-2019

Why do Pancreatitite prescribe platform hydrotatrate?

Strong spasms - a signal about the presence of problems in the body. The symptom may indicate different violations, therefore, depending on the disease, adequate medicine is selected.

Registration number and ATH

ATH code - A03A.

Registration number - P N002256 / 01-2003.

Platiminal hydrothatrate is a universal means suitable for the treatment of many diseases.

From what is prescribed

Indications for the purpose of the means are these pathologies and violations:

• angina;
• vascular spasms;
• damage to the gallbladder;
• ulcerative damage to the duodenum;
• colic arising in the liver or in intestinal spasmod;
• increased pressure (hypertension);
• lung diseases flowing into chronic form, including in weakened patients;
• the need to reduce the tone of smooth muscles;
• arsenic poisoning, boric acid or acetone;
• violation of motorcycles of biliary tract;
• pancreatitis;
• asthma exacerbation - medicine is assigned to prevent bronchial spasms;
• renal colic;
• ulcerative illness of the stomach, accompanied by a spasp of a smooth muscles of the organ;
• inflammatory process that struck the mucous membranes of the esophagus;
• reduced heart rate (bradycardia) flowing on arrhythmia.

In ophthalmology, medication applies to fulfill the following diagnostic measures:

• identifying pathologies: iridocyclitis, irita or keratitis;
• studies of eye injury;
• defraction definitions;
• studying the eye dna.

pharmachologic effect

The medicine is a m-cholinoreceptor blocker and has the following features of pharmacodynamics:

• violates the transfer of nerve impulses;
• improves the conductivity of the heart;
• inhibits the secretion of bronchial glands;
• contributes to the extension of vessels;
• inhibits the work of the internal secretion glands to a lesser extent compared to;
• lowers arterial pressure due to the expansion of vessels and blocking of sympathetic ganglia;
• reduces the tone of smooth muscles.

The pharmacokinetics of the medication is represented by similar characteristics:

• exposure to hydrolysis, resulting in platinoscopic acid;
• good absorption.

The active ingredient is metabolized in the liver.

Composition and form of production of hydrotathe platoofillin

The medicine is produced as a solution for subcutaneous administration. The medication is contained in ampoules.

As active substance Applied Platimatin hydrothatrate.

An additional component is distilled water.

How to prick platofillin hydrothatrate

The tool is injected intramuscularly or intravenously. If necessary, medication is used locally or rectally.

Dosage

Duration of application

The duration of therapy depends on the severity of the course of the disease and the age of the patient.

The duration of the medication is selected individually.

Features of application

Pregnancy and lactation

Security Information Tools for Application breastfeeding And there is no pregnancy. Consultation with a specialist is necessary.

Childhood

The medication is appointed with caution.

Elderly age

The therapy of elderly patients should be carried out in compliance with the rules of security.

When violations of the liver function

With violations of the kidney function

Used with caution in the presence of a patient with any forms of renal failure.

Side effects of hydrotathe platoofillin

Adverse reactions are characterized by the following features:

• headache;
• dry mouth and thirst;
• urine delay;
• increased excitation;
• convulsions;
• psychosis;
• accommodation paralysis characterized by impairment of view on small distances;
• reducing the heart rate reduction (tachycardia);
• reduced pressure;
• a decrease in the contractile ability of intestinal peristals (atony);
• expansion of pupils;
• dizziness.

Impact on the management of the vehicle

During the use of the drug, it is necessary to refrain from driving a car.

Contraindications

The drug is prohibited to apply for the treatment of patients suffering from the following pathologies:

• miasthenia;
• deterioration of the contractile ability of intestinal muscles;
• clothing glaucoma;
• ulcerative colitis, because High doses may result in intestinal obstruction;
• hypersensitivity to medicine;
• paralytic intestinal obstruction.

Interaction with other drugs

When sharing the platform of hydrotrite with other drugs, the following effects of interaction appear:

• sedative and hypotensive medicines enhance the time of the drug during vascular type spasms;
• mAO inhibitors lead to a positive battlefield effect, but the risk of adverse signs is increasing;
• analgesics enhance the effect of hydrotathe platoophylline in spasms of smooth muscles;
• morphine contributes to the oppression of the cardiovascular system;
• antihistamine medicines and other M-cholinoblocators increase the likelihood of side effects;

Compatible with alcohol

The tool is not combined with alcoholic beverages.

Overdose

If the medication is used in unacceptable dosages, signs arise:

• respiratory failure; reduced pressure;
• excitation that is replaced by the oppression of the central nervous system;
• an increase in intraocular pressure;
• dyspnea;
• an increase in the frequency of heart cuts;
• violation of consciousness;
• difficulty urination;
• lowering the tone of the intestinal wall;
• paris accommodation.

Conditions of vacation from pharmacies

Recommend to the recipe in Latin.

How much is

Price - 50-70 rubles per pack.

Storage conditions

It is necessary to protect the medicine from sunlight.

Shelf life

Give for 5 years.

Analogs

The drug can be replaced with analogues to which funds belong:

1. Infofol - medicine with antispasmodic and M-cholinolitic effect.
2. Aproofen - contributes to the expansion of vessels and eliminates spasms.
3. Sports - reduces the contractile activity of the muscles of the gastrointestinal bodies.
4. Skptolamine is a means with a sedative and antiemetic effect. Available in the form of a solution.
5. Metacin - means in the form of a solution and tablets affecting M-cholinoreceptors. Reduces the tone of smooth muscles.
6. Blessing is a medication with phenylsalicylate and beautification extract.
7. Atropine sulfate - a medicine of cholinolitical exposure, produced in the form of a powder for the preparation of a solution. It has spasmolytic and mydritic properties.

The drug can be replaced by analogues to which metacin belongs.