Heptral is a hepatoprotector with antidepressant action from Ebbot Corporation. The medicine is shown to the appointment in the composition complex therapy Many diseases that affect the liver, for example, when hepatitis C, cholestasy, or accompanied by depressive states. The medicine is produced in tablets (with a dosage of 400 or 500 mg of adhemationine in each) and in flocks with powder powder for parenteral solutions.

"Heptral": indications for use

Heptral refers to the hepatoprotective drug group. However, adhemethionine, which is part of its composition, "works" not only in the liver: it has a pronounced antidepressant effect. The drug can be used as parenterally (intravenously, intramuscularly) and inside. How to apply it, determines the attending physician. The method of use and necessary doses depend on what disease it is assigned.

For example, with an abstineent syndrome, it is advisable to use a parenteral medicine.

Heptral is shown for appointment at:

• liver inflammation (hepatitis);
• joy of bile (cholestazakh);
• inflammation of bile ducts (cholangitis) and non-calculous inflammation of the gallbladder (cholecystitis);
• fibrosis and cirrhosis of the liver;
• treatment of dependencies and abstinence syndrome;
• depressions and encephalopathy.

Contraindications for drug admission are the individual characteristics of the patient's body (allergic reactions, individual intolerance, age up to 18 years, methionine methionine metabolic disorders, cysteine, mental disorders).

"Heptral": adverse reactions

From the use of "Heptrala" one can expect the emergence of various types of unwanted actions from:

• digestive organs: nausea, vomiting, esophagitis, painfulness in stomach and stomach, flatulence, intestinal bleeding, diarrhea;
• cardiovascular system: Phlebitis, arrhythmias, heartbeat, bradycardia, raising or decrease in blood pressure;
• nervous system: Cefalgia, dizziness, irritability, insomnia, nervousness;
• skin: itching, rash, allergic skin reactions;
• muscles and joints: arthralgia, muscle spasms;
• kidney: infections, swelling.

With its admission, it is possible to overall making, weakness, subfebrile temperature, chills.

With caution, it is necessary to refer to the use of "heptra" to persons, cargo cars and complex devices. In the first days of use, the medication is desirable to refuse to control the car and dangerous mechanisms to eliminate possible dizziness and reduce attention during this.

Unwanted interactions with other drug drugs drug not visible. Symptoms of excess serotonin are possible when it is simultaneously admission to antidepressants and means containing tryptophan.

The list of possible adverse reactions depends on the form of the drug and the method of its use. Each manufacturer's country produces the drug only in one of the dosage forms - in the intestinal soluble tablets or in the flock powder. The heptral production of France, Greece or Germany is produced in vials, and the Italian drug is in the form of tablets. Accordingly, adverse reactions in the form of phlebitis will more often occur when the French production medication is applied, and pain in the stomach or other reactions from the digestive system - when taking the Italian production tablets.

Heptral: Medical Course

Begin treatment of adhemationine is necessary with parenteral administration. After intravenous or intramuscular course (14-20 days), the reception of the tableted form of the drug is assigned.

How many days later parenteral therapy will last, how much to drink tablets and what will be the duration of the entire course of treatment with "hepta" is determined by the doctor, taking into account the severity of the course of the disease and the response of the body to therapy (by biochemical indicators). On average, the parenteral part of the course of treatment lasts from 14 to 20 days, and tableted - up to 2 months. With sluggish diseases, for example, with hepatitis C, the duration of the course can be 4 or more months.

The recommended daily dose for parenteral use is 5-12 mg, and for receiving inside - 10-25 mg of the active substance for each kg of patient weight. Tablets are taken, not chewing and not blocked. Considering that the pills are produced with a dosage of 400 or 500 mg of adhemationine in each, this dose is recommended to divide for 2-3 receptions and take in the first half of the day.

Heptral: Analogs

In pharmacies, you can find other agents based on adhemationine: Heptor's pharmaceutical and a variety of biologically active additives (dietary supplements). All of them are produced in tablets. The drug-analogue "Heptor" is also available in powder in bottles and with a solvent in ampoules.

"Heptral" or "Heptor": What is better?

Heptral - Posted trademark, original drug produced by a group of European companies to order the Pharmaceutical Corporation "Ebbot". On the pharmaceutical market there is also another drug based on adhemationine - "Heptor". Its producer is Russian pharmaceutical company "Veropharm". Heptor is produced in intestinal-soluble tablets with an ademethionine content in the amount of 400 mg.

What of them take better: "heptral" or "heptor"? Opinions of doctors on this occasion are returned: some consider the original tool, others do not see the difference in their effectiveness. Both medications have similar indications, contraindications and adverse reactions. The great advantage of the "heptor" is its affordable price, and Heptrala is the possibility of applying parenterally, which increases the list of diseases in which it can be applied.

And Heptral, and Heptor are amino acid hepatoprotectors, but not to all people suffering from liver diseases, it is precisely amino acid adhemationine to restore hepatic functions. As part comprehensive treatment Hepatoprotectors based on:

• other amino acids ("Hep-Merz", Heptor-Farmex);
• phospholipids with vitamins, organic acids ("Essentialy", "Esshenitzal Forte", "Phosphorus");
• bile and bile acids (Ursosan, URSOFALK);
• substances of animal origin ("hepatosan", "hepatamin");
• plant components ("Maxar", "Carsyl", "Hofitol");
• homeopathic means ("Galstina", "Hepel").

The unanimous opinion of doctors about the need to appoint some kind of hepatoprotectors does not exist. They have different properties and have different times the onset of the therapeutic effect, therefore, with different diseases, it will be unequally effective.

"Heptral" during pregnancy

Heptral is not recommended to apply pregnant in the first trimester when an active bookmark and the formation of the kid organs occurs. But in the second and third semesters the reception of the drug, on the contrary, is shown. Pregnant uterus rises from the cavity of a small pelvis in abdominal cavity And mechanically squeezes bile docks. As a result, pregnant women can appear temporary jaundice due to bile stagnation. Cholestasis is the main indication for the use of "Heptra" during the period of the child's rover.

Doctors adhere to the opinions that during pregnancy it is more expedient to appoint a medication intravenously in droppers: the reception of the tablets causes a unwanted load on the organs of the digestive tract.

"Heptral" and alcohol

Heptral restores the liver after alcohol abuse. It is often included in the complex treatment of alcoholic dependence and abstinence syndrome. From what state of the patient (acute or chronic) is planning to treat "hepta", the choice of the form of the release of the drug depends. Thus, in the treatment of chronic alcoholism, it is better to take tablets, and when removing the abstinence syndrome, use a solution for parenteral administration.

The course of treatment "Heptrall" can last not last one month, so patients are often interested in a doctor if you can drink alcohol during treatment. Speaking about the compatibility of "Heptrala" and alcohol, it is necessary to draw the attention of patients to the fact that the medication is intended for restoration of the liver, and alcohol and its decay products in human organism Very toxic to the liver. Does it make sense to be treated and cut off the liver?

"Heptral": reviews

Most of the recalls of patients who took Heptral, positive: medicine well eliminates pathological symptoms, improves digestion and well-being of patients. The only drawback of the drug, many happily consider its high cost, especially considering that the course of treatment requires not one drug packing.

thank

The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!

Heptral is a drug from a group of hepatoprotectors with an anti-depressive effect. The hepatoprotector has unique properties, such as the ability to improve bile outflow, normalize and improve the functioning of the liver, reduce the degree of damage to its cells in chronic diseases (hepatitis, cirrhosis, etc.) and damage to the organ (medication poisoning, poisons, alcohol, etc. d.), as well as prevent the liver rebirth in connect fabric. The latest heptra's ability is the ability to propagate the rebirth of the liver into the connecting fabric - this is, in fact, preventing cirrhosis and fibrosis against the background of long-term chronic diseases. Moderate antidepressant effect of the drug is used in the treatment of light psychological disorders.

Forms of release, varieties and composition of heptra

Currently, on the pharmaceutical market, there is only one type of drug preparation - it is heptral, which, in turn, is produced in two dosage forms - pills for intake and lyophilisate For the preparation of a solution for intravenous or intramuscular administration. However, there is still a biologically active additive with a similar name - heptlaight, which is only available in tablets for intake. This biologically active additive should not be confused with the drug, despite the very similar names.

In everyday life, almost no one calls drug forms of the drug completely, preferring to use certain terms and phrases to designate each variant, allowing you to easily recognize this or that form and variety of medication. Thus, heptral tablets are denoted by adding numbers to the word "heptral", reflecting the dosage of the active substance, for example, "heptral 400" or "heptral 400 mg".

For the designation of the lyophilisate for the preparation of a solution for intramuscular and intravenous administration, the following terms are used - "Heptral ampoules", "heptral injection" and "heptral injections". Food capacious terms allow you to quickly understand what is meant, all participants in conversation - and pharmacists, and doctors , and patients.

The composition of all varieties and dosage forms of hepta as an active substance enters admethionine in different dosages. Thus, heptral tablets contain 400 mg of adhemethionine. The lyophilisate contains 400 mg of the active substance for one bottle.
Heptrala tablets contain the following excipients:

• Silicon dioxide colloid;
• Microcrystalline cellulose;
• Carboxymethyl starch sodium;
• Magnesium stearate;
• Copolymer of methacrylic acid and ethyl acrylate;
• Macrogol 6000;
• Polysorbat;
• Siemeticone;
• Sodium hydroxide;
• Talc;
• Water.

Powder of lyophilisate does not contain any auxiliary components. However, the solvent for lyophilisate in addition to deionized water contains lysine and sodium hydroxide, which are necessary to stabilize the finished solution.

Heptral tablets have an oval, two-way form, covered with an intestinal-soluble shell of pure white or white-yellowish color and are produced in packages of 20 pieces.

Heptral lyophilisate is a white or white-yellow powder without any extraneous inclusions, fastened to glass bottles. Failed ampoules with a solvent are attached to the vials with lyophilisate, which is a transparent liquid of colorless or light yellow. A solution ready for use, obtained by mixing the lyophilisate with a solvent - transparent, painted in colorless or light yellow color, not having a visible precipitate or suspended particles. Heptral for injections is available in packages of 5 bottles with lyophilisate, to which 5 ampoules with solvent are attached.

Therapeutic effects of Heptra

Therapeutic effects of heptrala are as follows:

• Detoxifying effect;
• Halfainetic action;
• Choleretic action;
• Neuroprotective action;
• Hepatoprotective action;
• Antidepressive action;
• Antioxidant action.

All listed therapeutic effects Properties are provided by the properties of the active component of heptrala - adhemethionine. This substance is normally produced and is contained in all human cell cells, but its largest amounts are revealed in the brain and liver. That is why heptral has the most pronounced therapeutic effects on the liver and brain.

Hepatoprotective action consists in increasing the stability of the liver cells to various negative factors. Under the influence of hepta, liver cells become stronger and resistant to any damage, as a result of which the functional activity and the structure of the body are improved. In addition, the effect of the drug is improved by the process of growth and reproduction of liver cells, which replace the dead cell elements. The process of substitution of dead cells new, functionally active prevents the development of cirrhosis and liver fibrosis in chronic diseases (cholangitis, hepatitis, etc.).

Choleretic and chopinetic action is to increase bile production with the simultaneous intensification of its outflow from the gallbladder in duodenal gut. As a result of the choleretic effect, the bile is not stirred in the liver and does not expand its ducts, which contributes to the best functioning of the organ and the prevention of chronic inflammatory process. In addition, the chilestone effect normalizes the bile outflow from the gallbladder, which prevents and eliminates the cholestasis, and also prolongs the duration of the remission period during cholecystitis. Choleretic and chopinetic effects are preserved for at least three months after the cessation of the course of therapy.

The detoxifying effect is to reduce the production and neutralization of various toxic substances in the outside or synthesized by different organs and tissues. Heptral improves the functioning of the liver, which is much faster and more intensively neutralizes toxic substances than and the detoxification effect is achieved.

The neuroprotective action of heptrala is to increase resistance to negative factors of cerebral cells and nerve fibers. Thanks to this effect, even with severe poisoning and intoxication, encephalopathy is presented. In addition, heptral stimulates the growth and reproduction of nerve cells, due to which the substitution of dead cell elements occurs and fibrosis and sclerosis is propose.

The antioxidant effect consists in increasing the stability of all human cell cells to the damaging effect of free radicals.

An antidepressive effect is developing from 6 to 7 days of treatment and reaches maximum severity by the end of the second week of receiving the drug. Heptral will effectively stop depressions that are not amenable to amitripital therapy and interrupts the recurrences of this disorder.

In osteoarthritis, the drug reduces the intensity of pain and improves the recovery of cartilage tissue. In cirrhosis and hepatitis hepatitis reduces the strength and intensity of the skin, and also supports the level of bilirubin, the activity of alkaline phosphatase, asate, alt, etc. With toxic lesion of the liver (poisoning of poisons, drugs, drug intake, etc.) heptral reduces the phenomena of abstinence ("breaking") and improves the functioning of the organ.

Heptral - Indications for use

Heptral is shown to use in diseases that cause stagnation of bile in the liver, such as:

• Liver fluid dystrophy;
• Chronic hepatitis;
• Toxic liver damage by various factors, such as alcohol, viruses, drugs (antibiotics, antitumor means, antiviral and anti-tuberculosis drugs, tricyclic antidepressants, oral contraceptives);
• Chronic cholecystitis without rock formation;
• Cholangitis;
• Cirrhosis of the liver;
• Cholestasis inholenny (stagnation of bile in hepatic ducts) in pregnant women;
• Encephalopathy associated with hepatic insufficiency;
• Abstinence syndrome (alcoholic, narcotic);
• Depression.

Instructions for use

Consider the rules for use, dosage and therapy scheme with pills and heptrane solution.

Tablets Heptral - instructions for use

Tablets should be taken inside, swallowing entirely, not chewing, not scholating and not shredding in other ways, but drinking a small amount of water. The drug must be taken in breaks between meals, preferably in the morning hours, because heptral has a tonic effect.

You should not pull the pills from the blister in advance and shift into any box or a jar, as it can negatively affect the properties of the drug. Remove the pills from the blister is necessary immediately before receiving.

After the required number of pills is taken out of the blister, you should carefully look at them and evaluate the color. If the tablets are not white or white-yellowish, but painted in any other colors and shades, it is impossible to take them.

For various diseases Heptral should be taken in a daily dosage of 800 - 1600 mg (2 - 4 tablets). Usually, the daily dosage is divided into 2 - 3 receptions per day, the last of which is carried out by a maximum of 18-00 hours. Optimally taking heptral twice a day - in the morning after awakening, and between dinner and dinner.

The duration of the treatment of therapy heptral is individual, and is determined by the doctor based on the speed of normalization of the state. On average, the course of therapy continues from 2 to 4 weeks. Repeated treatment Heptral can be made through the interval of 1 to 2 months after the end of the previous course of therapy.

Instructions for the use of hepta injection (in ampoules)

Packaging for injections Contains bottles with heptrala lyophilisol and ampoules with solvent. It is this attached solvent that should be used to dilute the lyophilisate and obtaining a solution ready for intramuscular or intravenous administration.

With various diseases and pathologies of the liver, heptral is injected intramuscularly or intravenously at 400 - 800 mg per day (1 - 2 lyophilisate vial) daily for two weeks. Then, if necessary, you can continue therapy, going to the reception of heptrala in the form of tablets of 800 - 1600 mg (2 - 4 tablets) per day. The duration of reception of tablets after heptra injections should not exceed 4 weeks.

When depressed heptral is also administered intravenously or intramuscularly at 400 - 800 mg (1 - 2 bottles) per day daily, within 15 - 20 days. After completion of the course, it is possible to continue the heptra in the form of tablets of 800 - 1600 mg (2-4 tablets) per day for another 2 to 4 weeks.

For the introduction of the solution, intravenous injection is preferable compared to intramuscular, since the risk of complications is much lower.

The lyophilisate is always bred by a solvent immediately before administration, and not in advance. Ready solution should be used immediately and not stored even for several hours. If some part of the drug remained after performing the injection, then it must be disposed of, and not to leave until the next time.

Heptral can not be mixed in one syringe or a bottle with solutions containing calcium ions. With other solutions for infusions (for example, glucose, saline, etc.) the drug is compatible.

So, immediately before performing the injection, the solvent from the ampoule should be milled. To do this, the end of the ampoule is inscribed and gently shaped, after which the solvent is gaining a sterile syringe. From a vial with a lyophilisate, an aluminum coating of a soft cover is removed. Then the needle of the syringe with the solvent scored in it is introduced into the vial with a lyophilisate, the pitching soft cover through. The solvent is neatly produced into the vial, not allowing the sharp pressing of the piston so that the particles of lyophilisate do not scatter over the walls. Then, for the complete dissolution of the lyophilisate, without removing the needles, carefully chat the bottle from side to the side, without turning it upwards.

When all the lyophilisate is dissolved, the finished solution should be without impurities and suspended particles and painted in white or white-yellowish color. If there are particles in the solution or its color differs from white-yellowish, then the drug cannot be used, it should be thrown out.

Ready solution, subject to normal external view, dial into the syringe, which is removed from the plug. Then the solution is introduced by the same syringe intravenously or intramuscularly. You can add a solution into the dropper from the syringe and enter the drug in the form of intravenous infusion.

How to enter hepta intravenous (dropper)

An intravenously ready solution of heptrala obtained after dilution of the lyophilisate solvent can be administered in two ways - inkjet or infusion. The inkjet solution is administered unchanged by simply injected it into a vein (as at intramuscular injection). Infusion heptraral is introduced slowly, dropwise, and it is pre-added in 250-500 ml of physiological solution. The infusion administration of hepta is usually called the "dropper", as the drug really gets into a vein dropped.

For the inkjet administration of hepta, the lyophilisate is diluted immediately before performing the injection and dial into the syringe. Then the syringe is put on a thin needle for intravenous injection. Syringe hold B. vertical position The needle up and tapping a finger along the wall towards the needle holder so that all air bubbles accumulate in one place. Then press the syringe piston and produce a small amount of solution, which allows you to remove the air outward.

Next, the skin in the injection area is wiped with a tampon, moistened with an antiseptic, and gently introduce the needle to Vienna. Then the solution from the syringe is slowly introduced (the ampule is introduced at least 2 to 3 minutes). After that, the needle is removed from the vein and again wipe the place of puncture with a swab, moistened with an antiseptic.

For infusion administration, first the lyophilisate in the vial is divorced by a solvent from the ampoule. The finished heptrala solution is poured into an infusion solution. At the same time, the ratio is observed - one fluorite bottle by 250 ml of infusion solution. The infusion solution usually take saline or 5% glucose. The prepared infusion solution is installed in the system and begin to enter 15 - 25 drops per minute.

How to enter heptal intramuscularly

For intramuscular administration of heptrala immediately before performing manipulation, a solvent is lyophilisate. The finished solution is gained into the syringe, they attach a relatively long and thick needle to it, designed specifically for intramuscular injection. Should closely monitor that the syringe does not have a thin needle for intravenous or subcutaneous administration solutions because they can slip from the holder and go into the depths of soft tissues. Such needles that fell into muscles can be in them for years, periodically causing a pain in a person.

After a set of the solution in the syringe, it is held vertically, the needle up, and on the wall slightly tapping a finger in the direction from the piston to the needle, so that air bubbles gathered in one place. Then pressed on the piston, releasing a little solution into the air, which allows you to remove all the gas bubbles of the syringe.

The syringe prepared for the production of injection is laid on a sterile napkin or bandage. Then the injection site is wiped with a tampon moistened with an antiseptic. It is optimally injected into the side upper third of the thigh or in the upper outer third of the shoulder, since in these areas the muscles are close to the skin. You should not enter a solution into the buttock, since the muscles lie deeply and the risk of making subcutaneous injection.

Prepare the injection site, again take the syringe and introduce the needle deep into the tissue vertically to the skin surface. Then slowly pressed on the piston, releasing the entire solution in the tissue. After the introduction of the solution, the syringe is removed, and the injection site is again wiped with a tampon moistened with an antiseptic.

For the production of injection, each time deviates from the previous minimum of 1 cm to minimize the risk of bruising and abscesses.

special instructions

Older people (over 65) are well tolerated heptral, so the dosage reduction is not required. However, elderly people are encouraged to start receiving hepta with minimal dosages, gradually increasing them if necessary.

Against the background of treatment, a person can appear anxiety, which usually passes after a decrease in the dosage of the drug. Such anxiety is not an indication for cancellation of heptrala.

Since heptral has a tonic effect, then you should not enter or take the drug in the evening, shortly before the deposit to sleep.

When using hepta under cirrhosis of the liver, it is possible to periodically determine the concentration of residual nitrogen, urea and creatinine in the blood. Also, on the background of therapy, the drug is recommended to take vitamins of group B, especially in 12 and folic acid, since heptral is poorly absorbed by the lack of specified vitamins.

Do not apply the drug to relieve depression in people suffering from mania.

Impact on the ability to manage mechanisms

Heptral can provoke dizziness, so on the background of therapy with the drug, it is recommended to abandon any activity related to the need for high speed of reactions and concentration of attention.

Overdose

Heptral overdose cases were not recorded during the entire period of observation clinical application drug.

Interaction with other drugs

A confirmed and reliably established interaction of heptrane with other drugs was not detected. However, there are data from individual observations on the emergence of overpowering serotonin on the background of receiving heptrala. Therefore, it is recommended to use heptral with tricyclic antidepressants with caution, selective inhibitors Reverse seizure of serotonin and preparations containing in tryptophan.

Side Effects of Heptra

The pills and injections of heptrala can provoke the same adverse reactions, among which are most common nausea, abdominal pain and diarrhea. In addition to them, heptral in any dosage form can provoke the following side effects from various organs and systems:
1. The immune system:

• Highland swelling;
• Allergic reactions (swelling of quinque, skin reactions, shortness of breath, bronchospasm, pain in the back, tachycardia, bradycardia, etc.).

2. Skin covering:

• Irritation at the injection site.

3. Nervous system:

• Dizziness;
• Headache;
• Paresthesia (feeling of the running of goosebumps, etc.);
• Feeling of concern and anxiety;
• Confusion of consciousness;
• Fever.

8. Urinary tract infections.

Contraindications for use

The lyophilisate and pills of heptrala are contraindicated to use if a person has the following diseases or states:

• Genetic disorders that determine the impaired methionine cycle, homocideurium or hypergomocysthenemia;
• Vibrant vitamin metabolism in 12;
• Increased individual sensitivity to the components of the drug;
• Age under 18 years old;
• II II trimesters of pregnancy (until the 27th week of gestation inclusive);
• Breastfeeding period.

Heptral - analogs

The pharmaceutical market has synonyms and heptrane analogs. Synonyms are drugs containing the same active substance as heptral. Analogues consider other drugs from the hepatoprotectors group containing other actants, but possessing the most similar spectrum of therapeutic effects.

Synonyms heptra

• Heptor Tablets and lyophilisate;
• Heptor n tablets.

Analogues of Heptra The following drugs are:

• Brency Forte Capsules;
• Vg-5 tablets;
• Hep-Merz Granules and concentrate for the preparation of the injection solution;
• Hepatosan capsules;
• Hepor Capsules;
• Heptong solution for injections;
• Histidine solution for injections;
• Glutarteine \u200b\u200bconcentrate and solution for injection;
• Glutamic acid pills and granules for the preparation of the solution for intake;
• Dipana pills;
• Potassium orotat tablets and pellets for cooking syrup;
• Carnituity solution and tablets;
• CARNITTIN Capsules, solution and concentrate;
• Carsil Dragee;
• Carsil Forte Capsules;
• COMIRELT MN Solution for subcutaneous administration;
• Essliver Forte Capsules.

What is better heptra?

In medical practice there is no concept of "best" in relation to various drugs. Practitioners doctors prefer to use the term "optimal", under which the drug is understood, which is suitable for a particular person in the current situation in the best possible way. That is, for different people, depending on the individual characteristics at the same pathology, various drugs will be optimal. Moreover, for the same person suffering from chronic disease, various drugs can be optimal at different stages of life. It is a drug that optimally suitable concrete person in this situation will be the best for him.

Thus, it is impossible to distinguish any of the best drug, which would be invariably and equally effective in various diseases among different people. And in each situation, one or another drug may turn out to be the best. Therefore, it is not possible to distinguish a number of drugs that would be "better" heptra.

Choosing between heptales and other hepatoprotectors, you should navigate only on your own sensations. If someone is subjectively suited and transferred heptral, then it needs to be considered "the best" drug. If the same person at another point is more suitable, for example, Essentialya, then this particular drug will be "best", etc.

If we compare heptral with synonyms, also containing adhemationine as an active substance, then all the presented drugs are worse than heptrala in the pharmaceutical market, because more often cause side effects and are heavier tolere. From this position there is nothing better than heptrala.

The liver is the main body responsible for the detoxification of the body. Despite the high ability of liver cells to self-renewering, over time, it requires support that modern drugs can be provided, such as heptor or heptral. Below in a small review, we tried to tell about their therapeutic efficacy and the main differences.

What is the difference between hepta and heptor?

Preparations belong to the group of hepatoprotectors and contain the same existing substance S-adenosyl-L-metyonine, registered entitled admethionine.

Heptor produced in Russia by Veropharm in the form of:

• tablets (0.4 g),
• lyophilisate (powder) for cooking injection form (0.4 g).

The origin is the main thing than the heptral heptor is different. This is an imported drug that produces pharmaceuticals Abbott Laboratories (Germany). Medicinal forms The same, but there is also a larger dosage of tablets of 0.5 g. So, the differences between drugs are minimal, and they can replace each other.

Action and effectiveness of ademethionine

Many biologically important molecules of our organism, proteins, nucleotide bases, carbohydrates, phospholipids have a methyl group. Almost 60 years ago, adhemationine coenzyme was opened, which, during biochemical reactions, adds a methyl radical to different molecules, making them active in the performance of its functions.

Admethionine has a number of biological effects:

• participates in the reactions of transmelorination, translucelifications and aminopropyllations,
• can restore glutathione antioxidant stock in the liver,
• regulates growth, differentiation and apoptosis of hepatocytes,

• increases interferon antiviral effect,
• has a contradressive action
• is safe I. effective drug To reduce jaundice,

The liver can be considered as an adhemationine plant, since 85% of all transmelorination reactions and 50% methionine methiolar metabolism passes in it. At the same time, the organ struggling with:

In patients with chronic liver disease, admethionine biosynthesis is suppressed, and therefore one of the principles of therapy of such states is the introduction of it from the outside.

In Russia and in some European countries, this substance is a drug, and in the USA it is registered only as food additive (SAM). Over the past 20 years, 11 major international clinical studies Admethionine, which included 705 patients with 7 kinds of chronic liver diseases.

A reliable reduction in the level of hepatic aminotransferase (ALT / AST) and other indicators in some chronic diseases and alcohol defeat after the course of adhemationine is from 400 to 1000 mg per day. However, in the treatment viral hepatitis Placebo-controlled tests did not reveal its effectiveness.

Another study conducted in India in 2013 included 250 patients with intrahepatic cholestasis. Admethionine was prescribed in a complex with other drugs and, according to the evaluation of doctors, this led to a decrease in the severity of the symptoms of the disease and the normalization of hepatic samples.

What is hepta and heptor differ from other hepatoprotectors?

Direct comparison of hepta with other hepatoprotectors incorrectly, since they all have a different mechanism of action. Preparations of this series can be divided into 3 groups:

1. preventing hepatotoxins,
2. warning damage to liver cells,
3. contributing to healing and restoration.

All known essentials restores the hepatocyte membranes, and the extract of the milk thistle contained in the carcylene and hepatrine, activates their division (regeneration). When performing its important tasks, the liver consumes vitamins and bile acids, so these substances as hepatoprotectors are located as part of the popular drugs of Ursosan and Essliver.

Preparation "Hepatrine"

Widely spent amino acids in the liver are aspartate, ornithine and methionine. The first two are contained in the preparation of Hep-Merz, and methionine - in heptor and its analog.

Medicines heptral or heptor, like other hepatoprotectors are prescribed depending on what is better consistent with the treatment profile. The appointment depends on the symptoms of the disease, the degree of damage and the concomitant factors (age, alcoholism, transferred diseases, etc.). No need to quickly drink hepatoprotectors in order to "clean" the liver. This can lead to the opposite effect and aggravate the painful state.

Cost of treatment

The injection form of hepatoprotectors is prescribed by the course 2 weeks 2 AMP / SUT (check with your doctor's doctor the dosage you need!). A total of 28 ampoules or almost 6 packs of medication will be required. Packaging heptrala (5 AMP) costs about 1700 rubles, and the whole course will cost about 10 thousand rubles. The lyophilisate of domestic production is cheaper 1.4 times.

The average cost of packing of the heptor tablets (20 pcs.) Is about 800 rubles. Heptral in the same dosage and quantity is approximately 1.5-2 times more expensive.

Heptral or heptor - what is better?
- All about medicines for the site

Information The site is a reference and generalizing, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medicines in the course of treatment.

The liver is an important organ in the body, so any pathology significantly worsen the quality of human life. To restore organ functions, different means are used, but hepatoprotectors have proven themselves in the treatment of the liver and are very popular in patients. Heptor or heptral - what is better, the opinion of doctors. The pharmacies are present both original drugs and generics, their price is quite different, so it is necessary to understand the main differences in two analogues.

Both medicines belong to hepatoprotective drugs with antidepressant effect. The main task of drugs is aimed at regeneration of liver cells - hepatocytes, which are involved in blood purification process and may suffer due to the increased influence of toxic compounds.

These drugs are prescribed with various pathologies of liver, such as cirrhors or hepatitis, cholecystitis and other diseases. Their use allows you to stop the destructive influence of viruses or toxins and include the mechanism of regeneration of the Parenhima organ.

Features of drugs:

1. Heptral is produced in Italy, is the original hepatoprotective agent with the passage of relevant research and the perfect combination medical components For the effectiveness of treatment.
2. Heptor is manufactured in Russia and is a generic. This means that its composition is copied from the original drug without passing tests, it is permissible to use the raw material of the worst quality, but the price of such a drug will be 2-3 times lower.

It is important to understand that these medicines are not a means of preventing liver pathologies, therefore should be taken in strict accordance with the appointment of a doctor. During therapeutic therapy, you should stick to the gentle menu and eliminate all synthetic and harmful products.

The main effect of heptraly is aimed at regeneration of the liver parenchyma, the medicine exhibits such properties:

• antioxidant;
• restorative;
• neuroprotective;
• protection against fibrous formations.

And the drug has a clearly pronounced property - removal of the depressive state of the patient. The main operating component has a multilateral effect on the patient's body:

1. Prevents the occurrence of pathological foci in the liver of various nature.
2. Eliminates the pathology of the nervous system, which are a consequence of alcohol intoxication. Neurotic and depressive states are counted here. The peak effect is achieved by the tamph of medication.
3. Heptral contributes to the intensification of the production of yellow, which has a beneficial effect on the digestive system, improves intestinal peristalsis.

Indications for the preparation of the drug are such pathologies:

• damage to the energy production mechanism in the body;
• chronic form cholecystitis (without rock formation);
• encephalopathy;
• hepatosis, cirrhosis;
• hepatitis of viral, drug or toxic nature (hormonal or highly toxic drug therapy);
• abstineent state or depression.

Medication is prescribed by the attending physician (hepatologist) after passing necessary diagnostics patient.

The success of therapeutic therapy will depend on the right reception of the drug, as well as on compliance with all the recommendations of the doctor regarding nutrition, sleep and physical exertion for the patient. Proper food will help to improve the liver, help the body to lose weight if excess weight.

The medication is available in the form of tablets or in the form of ampoules for injections that are entered into vein. The ampoules are divorced by lyophilisate (L-lysine). When using heptra, there are features:

• slow administration of medication;
• per day is allowed to introduce 400-800 milligram drugs;
• treatment term in 2-3 weeks;
• the introduction of the medication in the first half of the day, since it has a clearly pronounced invigorating effect;
• in case of complex liver states, heptral in ampoules is used to stabilize, it is later permissible to switch to the tablet form;
• tablets are accepted by one-piece, in the first half of the day, moaned with clean water.

The duration of the course of medication depends on the state of the patient and is determined by the doctor individually, so treatment can exceed 3 weeks.

Heptral is well tolerated by patients, and manifestation side Effects It is extremely rare, the symptoms are expressed weakly. These include heartburn, manifestation of arrhythmias or digestion of the gastrointestinal tract. Headache and insomnia, as well as allergic symptoms - Itching or urticaria. With manifestation side phenomena Consult your doctor.

During pregnancy, the use of the drug is prohibited in 1 and 2 trimesters, for the third trimester is necessary special instructions Specialist, such as heavy cholestasis pregnant. During lactation, the medicine does not apply, so it is necessary to stop breast-feeding.

It is also not used by the drug in the presence of allergies, ulcers, aggressive and feverish states. It is impossible to take an increased dose of drug treatment, as this can increase by-manifestations.

Acceptance of medication Heptor fills the lack of adhemationine and stimulates it in the body. The effect of medication is directed to:

• enhancing protective functions and liver regeneration;
• stimulation of highlighting of yellow;
• antioxidant effect;
• protection of the nervous system;
• blocking fat or fibrous liver pathologies;
• improving the mental state of the patient.

Most often, the heptor is prescribed during such pathologies:

1. Hepatitis of various nature - viral, toxic, reactive.
2. Fibrosis or cirrhosis.
3. A disorder of the horizontal function.
4. Encephalopathy.
5. As a method of prevention during chemotherapy or reception of highly toxic drugs (for example, hormones).
6. Abstineent state or depression.

The medicine has a positive effect on the cellular composition of the liver tissues, forcing hepatocytes to output toxic and other poisonous compounds, includes active regeneration and protective functions of the organ.

The maximum treatment effect is achieved using a wellness diet and exercise.

Gentle nutrition significantly reduces the toxic effect on the liver and makes it possible to start the organ recovery processesAnd sport stimulates the active exchange and elimination of toxins from the body. The bonus will be slimming if the patient suffers from excess weight.

The drug is produced in Russia, in pharmacies can be found in the form of tablets or ampoules for administration to vein or intramuscularly. The ampoules are divorced by a lyophilisate, which goes along with the medicine.

Features of the use of heptor:

• ampoules are prepared immediately before injection. Used for injections and droppers, it is required extremely slow intravenous administration drug;
• daily dose is 0.8-1.6 grams of drugs in tablets, and in ampoules 0.4-0.8 grams;
• the medicine is accepted in the first half of the day, the tablets must be used between breakfast and lunch;
• ampoules are prescribed during acute liver pathologies, after stabilization of the patient's state, you can switch to the tableted form of the drug.

Long therapy is determined by the attending physician and depends on the set of factors, an average treatment takes 2-4 weeks, during sharp states the duration can double. Also used therapy by courses.

Side effects often appear weakly, many develop only at the beginning of treatment and quickly pass. These include:

1. Possible pain or nausea, as well as diarrhea. Infectilation of small pelvis organs may develop.
2. Manifestation of migraine, sleep disturbance, dizziness. Rarely commemorates muscles.
3. Allergic effects in the form of itching or urticaria, heavy complications - Svetq quinque, anaphylactic shock, Svetka Lastani.

And also possible manifestations general weakness, primary symptoms of influenza, chills or elevated temperature, which also may indicate the presence of side effects. It is necessary to inform you to inform the doctor about the status and correct therapeutic therapy.

The drug is well tolerated by patients quite well and practically does not cause side effect. But there are factors that prohibit the admission of heptor:

• allergic reaction to components;
• 1 and 2 trimester of pregnancy, lactation period;
• age up to 18 years.

Also, the drug is used with special care:

• in psycho-emotional disorders, in rare cases, a negative manifestation of mania is possible;
• for renal failure, during the cirrhosis against the background of an excess of nitrogenous protein metabolic products in the patient's blood;
• if the patient suffers in the lack of vitamin B12 and folic acid, the necessary complex will contribute to therapeutic therapy;
• elderly patients first apply the minimum dose and if the body transports normally, gradually increase the dose to optimal.

And it should also be reduced to a minimum management of motor vehicles or complex mechanisms that require attention and reaction.

The use of the drug in the 3 trimester of pregnancy did not cause any destructive influences on the fetus, therefore allowed for the treatment of future mom. During breastfeeding, the drug is not used.

When using the medicine heptor reviews specialists have a positive color, but with small details. Medicine qualitatively affects general state patients and improve emotional tone.

The advantage of the drug is his affordable priceTherefore, it is suitable for most patients for long-term liver recovery therapy. Some doctors on the forums note that this is the only active hepatoprotector from drugs of domestic production.

If you compare the difference between the heptral medication with heptor, according to the reviews of patients, there is a slow motion effect of the first drug, but this is compensated by the price.

Heptral Reviews

Both doctors and patients celebrate high efficiency medication. Liver indicators are rapidly improved, and the tone rises and a positive attitude appears in the patient, which is important for successful therapy. It is used by patients as part of a comprehensive treatment.

Doctors noted that the ampulle release form quickly and effectively relieves pain, reduces inflammation and helps the liver recovery. But the drug in tablets acts slower, so heptral heptral is often appointed with acute liver pathologies.

After stabilizing the condition of the patient, you will rotate to prescribe a tablet form as hepta, the heptor. If the patient is a multi-month hepta therapy not by pocket, you can safely choose heptor, the effectiveness of tablets or capsules is almost identical. Other differences patients and doctors noted.

The only minus of the drug heptral patients call a high price, otherwise negative reviews are practically absent.

Heptral is a medicine related to hepatoprotectors. It is intended mainly to normalize the functioning of the liver. Also, the medication has an anti-depressive effect. Typically, doctors prescribe heptral patients suffering from cirrhosis, chronic hepatitis, inflammation of the gallbladder and its ducts, cholestasis, alcoholism. In pharmacies you can find efficient, but cheaper analogs of the drug.

Effect of drug on the human body

The drug effectively affects the liver tissue. The active ingredient is the ademethionine necessary for proper metabolism.

This substance supports protective forces of hepatic tissues at the optimal level, but its amount in the body decreases due to age and negative factors.

Often, a decrease in the concentration of adhemationine is associated with the emergence of depression in a patient. Heptral not only eliminates the deficiency of adhemationine in the body, but also stimulates the synthesis of matter in the tissues of the liver and brain.

Based on the foregoing, the drug has the following impact on the body:

• activates the production of bile;
• helps bile stand out in the intestinal tract;
• normalizes the functioning of hepatic tissues;
• removes toxic compounds from the body;
• prevents damage and early aging of body tissues;
• it has a strong antidepressant effect.

Application of drug

The reception of heptrala is allowed by a doctor's prescription. Tablets are accepted by 1 piece 3 - 4 times a day. It is advisable to receive before noon between breakfast and lunch.

The tablet is swallowed without chewing, watered with water. The course of treatment usually lasts a month.

It happens that the doctor prescribes heptral in the form of a solution for injections. In this case, the daily dose of medication ranges from 400 to 800 ml. Drug Solution introduced by either dropper or intramuscular injection. For 2 - 3 weeks, intensive therapy is carried out, then a supporting treatment is carried out about 4 weeks.

The hepatoprotector has a tonic effect on the body, so it is not recommended to take before bedtime, sometimes insomnia may occur. Also should not use a medication before controlling vehicle or before work for complex mechanismBecause the active ingredient drug can cause dizziness and negatively affect the concentration of attention.

Contraindications

The list of contraindications is small. It is forbidden to use the drug:

• people sensitive to the components of the drug;
• pregnant women, especially in the early launchers of the fetus;
• breastfeeding mothers;
• children and adolescents under the age of 18.

It should be extremely careful to use medicine to people suffering from manic-depressive psychosis.

It is undesirable to use the drug in renal failure, when taking tricyclic antidepressants and tryptophans. Elderly to apply heptral is allowed, but under medical control.

Side effects

Usually, the medication does not cause unpleasant reactions of the body. Side effects are noted only if the instructions for use are not compared. From side effects most often observed:

Cost of heptra

You can buy the drug in any pharmacy by providing a doctor's recipe. It costs heptralshevo. Packaging, including 20 tablets, will cost the buyer at 1450 - 1500 rubles. And the injection solution is also more expensive: 1650 - 1800 rubles. Such an expensive medicine for pocket is far from all customers. Fortunately, there are many analogues of heptrala standing cheaper.

List of cheap heptra

How to replace expensive heptral? From cheap and efficient analogs of the drug can be noted:

• Heptor (Russia);
• Phosphoglie (Russia);
• Esssential (France);
• Berlition-600 (Germany);
• Reserve about (Germany);
• Phosphycial (Russia);
• Livolin Forte (Thailand);
• Hepatosan (Russia);
• Carsil (Bulgaria);
• Ademethionine-Wal (China);
• Maxar (Russia).

Heptral or heptor - what is better?

Heptor and hepta - analogues on the active component. Both drugs are intended to eliminate liver pathologies: cirrhosis, cholestasis, alcohol poisoning, hepatitis, secondary encephalopathy.

Also, medicines are eliminated from depression, returned to the norm mental and emotional patient's condition.

Heptor has a tonic effect, so it is desirable to take it to lunch to avoid insomnia. The dosage is established by a doctor, but is usually 800 - 1600 mg per day. The drug is contraindicated in pregnant women, children, people with intolerance to the components of the drug. In case of overdose, an allergic reaction is noted.

Packaging heptor, including 20 tablets, costs 700 - 950 rubles.

What to choose - Heptor or Heptral? According to doctors, both medications act equally efficiently. But heptor is the only cheap analog Heptrala for chemical composition.

Heptral or phosphoglie - what to purchase?

Phosphoglie - analogue of heptra pharmacological groupbut not by chemical composition. Active components The drug is phospholipids and glycyrrhizinic acid.

These actors purify the liver tissue, restore damaged organs of the organ, have an antioxidant and anti-infectious effect. Glycyrrhizinic acid is able to inject a viral infection.

Phosphorus is intended for the treatment of cirrhosis, hepatitis, liver poisoning to toxins or alcohol. It is impossible to take the drug to children under the age of 12. Reception is carried out at 1 - 2 capsule 3 times a day during meals.

Heptral or phosphoglie - what is better to choose? These medicines have a different chemical composition. Heptral is a hepatoprotector relating to amino acids, and phosphoglie is a standard drug for liver disease therapy.

Heptral restores damaged liver cells, enhances the body's ability to fight toxins. Phosphogle eliminates the cause of the liver disorders - an inflammatory reaction, resulting in damage to the liver cells.

It should be noted that phosphoglie is the only medication from the hepatoprotectors group, which contains glycyrrhizinic acid. Phospholipids and glycyrrhizinic acid - a complex, standard used for the treatment of liver pathologies.

It stands phosphoglie not cheap, but cheaper than heptral. The average price is 800 rubles.

Heptral or Esssential - What to choose?

Essential is a hepatoprotector based on phospholipids allocated from soy. The drug is intended to treat violations of the liver: cirrhosis, hepatitis, body fatty organ.

Plus the Essentialist in the fact that the medication is easily transferred by the body, proper use Does not cause side effects. The drug is contraindicated only for children under 12 years old, and people having the intolerance to the components of the drug. Reception is carried out 2 capsules 3 times a day during meals.

At the price of Esssential, heptrala is much more profitable. Packaging, including 30 capsules, will cost 650 rubles, and containing 90 capsules, will be released at 1200 rubles.

Heptral or Maxar - what to buy?

Heptral - hepatoprotector based on components of synthetic origin. Maxar is a drug that includes a natural actant - Amur Maiac Extract.

In kind of origin is the advantage of Maxar. The drug acts on the body is softer than heptral, does not give side effects, if you follow the instructions.

Maksar or Heptral - what is better? According to doctors, heptral is optimally suitable for the treatment of severe inflammatory response in the liver, and Maksar is recommended to use when the disease is in the remission stage, there are no pronounced symptoms in the patient.

Maxar improves the yoy output from the ducts, as a result of which the patient disappears unpleasant symptoms: nausea, poor appetite, bitter taste in the language. There is a fairly monthly course of receiving medication to restore appetite, lead to a mass of body mass, eliminate depression.

The drug is forbidden to take pregnant women feeding breasts to mothers, children under the age of 18. Reception is carried out at 1 tablet 3 times a day half an hour before meals. The duration of the course of therapy is a month.

Maksar is cheaper than heptrala, therefore it is suitable for patients forced to pass several liver treatment courses. Packaging, including 50 tablets, will cost an average of 1150 rubles.