Glucose E solution. Drug: Glucose E. Contraindications to the use of glucose-u
Indications for use:
Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, intoxication with liver diseases (hepatitis, dystrophy and liver atrophy, incl. Liver failure), hemorrhagic diathesis; Dehydration (vomiting, diarrhea, postoperative period); intoxication; Collapse, shock.
As a component of various bloodstream and anti-shock liquids; For the preparation of LS solutions for in / in administration.
Possible substitutes:
Glucose (from 5.00 rubles), glucose Brown (from 28.00 rubles), glucose buffin (from 53.00 rubles), glucosteril (from 700.00 rubles), glucosteril 20% (from 700.00 RUB) Warning: the use of substitutes should be coordinated with the doctor.
Dosage form:
solution for intravenous administration, solution for infusion, pills
Contraindications:
Hypersensitivity, hyperglycemia, diabetes, hyperlactacidemia, hyperhydration, postoperative disorders of glucose disposal; circulatory disorders threatening the brain and lungs; Brain swelling, pulmonary edema, acute left vehicle failure, hyperosmolar coma.c caution. Decompensated HSN, CPN (oligognuria), hyponatremia.
Method of use and dose:
In / in drip, 5% solution is administered at a maximum speed of up to 7 ml (150 cap) / min (400 ml / h); Maximum daily dose for adults - 2 liters.
10% solution - up to 60 CAP / min (3 ml / min); Maximum daily dose for adults - 1 l.
20% solution - up to 30-40 Cap / min 1.5-2 ml / min; Maximum daily dose for adults - 500 ml.
40% solution - up to 30 CAP / min (1.5 ml / min); Maximum daily dose for adults - 250 ml.
B / in inkjet - 10-50 ml of 5 and 10% solutions.
In adults with normal metabolism, the daily dose of administered dextrose should not exceed 4-6 g / kg, i.e. about 250-450 g (with a decrease in the intensity of metabolism daily dose Reduce up to 200-300 g), while the daily volume of the injected fluid is 30-40 ml / kg.
Children for parenteral nutrition Along with fats and amino acids, 6 g of dextrose / kg / day are introduced on the first day, subsequently to 15 g / kg / day. When calculating the dose of dextrose with the introduction of 5 and 10% dextrose solutions, it is necessary to take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45 -100 ml / kg / day.
Introduction speed: at the normal state of metabolism, the maximum rate of administration of dextrose adults - 0.25-0.5 g / kg / h (with a decrease in the intensity of metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of administration of dextrose should not exceed 0.5 g / kg / h; As for 5% solution - about 10 ml / min or 200 CAP / min (20 cap \u003d 1 ml).
For a more complete absorption of dextrose administered in large doses, insulin is prescribed at the same time at the calculation of 1 sneakers at 4-5 g of dextrose. Patients with diabetes dextrose are administered under the control of its content in the blood and urine.
Participates in various metabolic processes in the body, enhances the redox processes in the body, improves the antitoxic liver function.
The infusion of dextrose solutions partially fills the water deficit. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively involved in many links of the organism.
5% Dextrose solution has a disintellation, metabolic effect, is a source of valuable easily durable nutrient. During the metabolism of dextrose in the tissues, a significant amount of energy is released, necessary for the vital activity of the body.
Hypertensive solutions (10%, 20%, 40%) increase the osmotic blood pressure, improve the metabolism; improve myocardial reductions; Improve the antitoxic function of the liver, extend the vessels, increase the diuresis. Theoretical osmolarity of 10% dextrose - 555 mosm / l, 20% - 1110 mosm / l.
solution for infusion
Owner / registrar
SPK, OJSC
International Classification of Diseases (ICD-10)
E86 Reduced liquid volume R57.0 Cardiogenic shock R57.1 Hypovolemic shock R57.8 Other types of shock T79.4 Traumatic shockPharmacological group
Drug for rehydration and disintellation for parenteral use
pharmachologic effect
Means for rehydration and disinfection.
An isotonic solution of dextrose (5%) is used to replenish the organism with liquid. In addition, it is a source of valuable nutrient that is easily absorbed. In the metabolism of glucose in the tissues, a significant amount of energy required for the life of the body is distinguished.
When in / in the introduction of hypertensive solutions (10%, 20%, 40%), the osmotic pressure of the blood increases, the current of the fluid from the tissues into the blood increases, the processes of metabolism increase increase, the antitoxic function of the liver increases, the cutting activity of the heart muscle increases, the vessels increase, increases diuresis.
Pharmacokinetics
Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively involved in many links of the organism. Excreted by the kidneys.
Reimbursement of lack of carbohydrates in the body. Correction of dehydration due to vomiting, diarrhea, in the postoperative period. Disinfecting infusion therapy. Collapse, shock (as a component of various blood-blowing and anti-shock liquids). Used to prepare for solutions of medicines for in / in administration.
Hyperglycemia, diabetes, hyperlactacidemia, hyperhyrastation, postoperative disorders of glucose disposal; circulatory disorders threatening the brain and lungs; Brain swelling, pulmonary edema, acute left vehicle deficiency, hyperosmolar coma.
From the metabolism: Disturbances of ion balance, hyperglycemia are possible.
From the side of the cardiovascular system: Hypervolemia, acute left left failure.
Others: fever.
Local reactions: Rarely local irritation, development of infection, thrombophlebitis.
special instructions
Caution is prescribed dextrose in decompensated heart failure, chronic renal failure (oliganuria), hyponatremia.
To increase the osmolarity, a 5% dextrose solution can be combined with an isotonic solution of sodium chloride.
With renal failure
Caution is prescribed dextrose in chronic renal failure (oliganuria).
Application in pregnancy and breastfeeding
It is possible to use dextrose during pregnancy and during lactation ( breastfeeding) According to the testimony.
Dextrose solutions are introduced into / in drip.
5% solution: maximum to 150 drops / min, maximum daily dose for adults - 2 l;
10% solution: maximum up to 60 drops / min, maximum daily dose for adults - 500 ml;
20% solution: maximum up to 40 drops / min, maximum daily dose for adults - 300 ml;
40% solution: maximum up to 30 drops / min, maximum daily dose for adults - 250 ml.
Release form: Liquid medicinal forms. Solution for infusion.
General characteristics. Structure:
Active Component: monohydrate dextrose (in terms of anhydrous) 50 g or 100 g;
auxiliary components: sodium chloride 0.26 g, 0.1 m hydrochloric acid solution to pH 3-4.1 (or to pH 3-6), water for injection to 1 liter.
Description:
Transparent, colorless liquid.
Pharmacological properties:
Pharmacodynamics.
Participates in various methods of metabolism in the body. The infusion of dextrose solutions partially fills the water deficit. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively involved in many links of the organism.
5% Dextrose solution isotonic blood plasma.
10% hypertensive solution increases the osmotic blood pressure, increases diuresis.
Theoretical osmolarity of 10% dextrose - 555 mosm / l.
Pharmacokinetics.
It is absorbed in a fully organism, the kidneys are not displayed (the appearance in the urine is a pathological basis).
Indications for use:
Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, intoxication during the disease of the liver (hepatitis, and, incl.) ,.
As a component of various bloodstream and anti-shock liquids: dehydration (vomiting,); ; shock.
For the preparation of drug solutions for intravenous administration.
Important! Get acquainted with treatment
Method of use and dose:
Intravenously drip.
5% (isotonic) glucose solution is introduced with a maximum speed of up to 7 ml (150 Cap / min or 400 ml / h); Maximum daily dose for adults - 2 l; 10% (hypertensive) glucose-e solution - up to 60 kap / min (3 ml / min); Maximum daily dose for adults - 1 l.
In adults with normal metabolisms, the daily dose of the administered dextrose should not exceed 4-6 g / kg, i.e. About 250-450 g (with a decrease in the intensity of metabolism, the daily dose is reduced to 200-300 g), while the daily volume of the injected fluid is 30-40 ml / kg.
Children for parenteral nutrition along with fats
The amino acids on the first day are introduced 6 g of dextrose / kg / day, subsequently to 15 g / kg / day. To calculate the dose of dextrose with the introduction of 5% and 10% glucose solutions, it is necessary to take into account the allowable amount of injected fluid: for children with a body weight of 2-10 kg is 100-165 ml / kg / day, children with body weight 10-40 kg - 45-100 ml / kg / day.
At the normal state of metabolism, the maximum introduction rate Glucose-e-adults - 0.25-0.5 g / kg / h (with a decrease in the intensity of metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the imposition rate of glucose-e should not exceed 0.5 g / kg / h; As for 5% solution - about 10 ml / min or 200 CAP / min (20 cap \u003d 1 ml).
For a more complete assimilation of dextrose introduced in large doses, insulin is prescribed at the same time short action At the rate of 1 uninterplication of a short action for 4-5 g of dextrose.
Sick diabetes mellitus is administered under the control of its blood content and urine.
Features of application:
For a more complete and rapid assimilation of dextrose, subcutaneously 4-5 units of a short action can be introduced, at the rate of 1 unin-insulin of a short action for 4-5 g of dextrose.
Side effects:
Hypervolemia ,.
At the place of administration - the development of infection ,.
Interaction with other drugs:
When combined with others drugs It is necessary to visually control compatibility (invisible pharmaceutical incompatibility is possible).
Contraindications:
Hypersensitivity, hyperhyrastration, diabetic coma, incl. hyperlactacidemia, postoperative disorders of glucose disposal; circulatory disorders threatening the brain and lungs; , Outragia left vehicle failure ,.
Carefully:
Decompensated, (Oliguria,), pregnancy and lactation period.
Overdose:
Symptoms: hyperglycemia, glucosuria, hyperglycemic hyperosmolar coma, hyperhyrastration, violation of the water and electrolyte balance.
Treatment: stop the introduction of glucose-e, introduce short-acting insulin, symptomatic therapy.
Storage conditions:
In a dark place, at temperatures from 2 to 25 ° C.
Keep out of the reach of children.
Shelf life - 2 years.
Do not use after the expiration specified on the package.
Leave terms:
On prescription
Packaging:
100, 200, 400 and 500 ml in glass bottles for blood, transfusion and infusion preparations, with a capacity of 100, 250, 450 and 500 ml, respectively.
100, 200, 250,400 and 500 ml in a bottle of polymeric capacity 100, 250 and 500 ml, respectively.
100, 250, 500 ml into polymer containers for single-use infusion solutions.
Each container of polyvinyl chloride is placed in a bag of polyethylene film.
1 bottle with instructions for medical application Place in a pack of cardboard boxes.
2 bottles with a capacity of 100 or 250 ml or 15 bottles with a capacity of 450 or 500 ml with an equal number of medical instructions are placed in the boxes of corrugated cardboard with gaskets and lattices "sockets" from corrugated cardboard [for hospitals].
72 container container or bag with a capacity of 100 ml, 34 containers or a container bag with a capacity of 250 ml or a container 22 container or a bag with a capacity of 500 ml with an equal number of medical instructions are placed in the boxes of corrugated cardboard [for hospitals].
solution for intravenous administration, solution for infusion, tablets
Pharmachologic effect:
Participates in various metabolic processes in the body, enhances the redox processes in the body, improves the antitoxic liver function. The infusion of dextrose solutions partially fills the water deficit. Dextrose, entering the tissue, phosphorylated, turning into glucose-6-phosphate, which is actively involved in many links of the organism. 5% Dextrose solution has a disintellation, metabolic effect, is a source of valuable easily durable nutrient. During the metabolism of dextrose in the tissues, a significant amount of energy is released, necessary for the vital activity of the body. Hypertensive solutions (10%, 20%, 40%) increase the osmotic blood pressure, improve the metabolism; improve myocardial reductions; Improve the antitoxic function of the liver, extend the vessels, increase the diuresis. Theoretical osmolarity of 10% dextrose - 555 mosm / l, 20% - 1110 mosm / l.
Indications:
Hypoglycemia, insufficiency of carbohydrate nutrition, toxicoinfection, intoxication with liver diseases (hepatitis, dystrophy and liver atrophy, incl. Liver failure), hemorrhagic diathesis; dehydration (vomiting, diarrhea, postoperative period); intoxication; Collapse, shock. As a component of various bloodstream and anti-shock liquids; For the preparation of LS solutions for in / in administration.
Contraindicated:
Hypersensitivity, hyperglycemia, diabetes, hyperlactacidia, hyperhydration, postoperative disorders of glucose disposal; circulatory disorders threatening the brain and lungs; Brain swelling, pulmonary edema, acute left vehicle failure, hyperosmolar coma.c caution. Decompensated HSN, CPN (oligognuria), hyponatremia.
Side effects:
Hypervolemia, acute left left failure. At the place of administration - the development of infection, thrombophlebitis. Decoration. Hyperglycemia. Treatment is symptomatic.
Method of use and dose:
In / in drip, 5% solution is administered at a maximum speed of up to 7 ml (150 cap) / min (400 ml / h); Maximum daily dose for adults - 2 liters. 10% solution - up to 60 CAP / min (3 ml / min); Maximum daily dose for adults - 1 l. 20% solution - up to 30-40 Cap / min 1.5-2 ml / min; Maximum daily dose for adults - 500 ml. 40% solution - up to 30 CAP / min (1.5 ml / min); Maximum daily dose for adults - 250 ml. B / in inkjet - 10-50 ml of 5 and 10% solutions. In adults with normal metabolism, the daily dose of administered dextrose should not exceed 4-6 g / kg, i.e. About 250-450 g (with a decrease in the intensity of metabolism, the daily dose is reduced to 200-300 g), while the daily volume of the injected fluid is 30-40 ml / kg. Children for parenteral nutrition, along with fats and amino acids, 6 g of dextrose / kg / day are introduced on the first day, subsequently - up to 15 g / kg / day. When calculating the dose of dextrose with the introduction of 5 and 10% dextrose solutions, it is necessary to take into account the permissible volume of the injected fluid: for children with a body weight of 2-10 kg - 100-165 ml / kg / day, children with a body weight of 10-40 kg - 45 -100 ml / kg / day. Introduction speed: at the normal state of metabolism, the maximum rate of administration of dextrose adults - 0.25-0.5 g / kg / h (with a decrease in the intensity of metabolism, the rate of administration is reduced to 0.125-0.25 g / kg / h). In children, the rate of administration of dextrose should not exceed 0.5 g / kg / h; As for 5% solution - about 10 ml / min or 200 CAP / min (20 cap \u003d 1 ml). For a more complete absorption of dextrose administered in large doses, insulin is prescribed at the same time at the calculation of 1 sneakers at 4-5 g of dextrose. Patients with diabetes dextrose are administered under the control of its content in the blood and urine.
