It is difficult to find a person who would not have a teeth hurt, the temperature was not raised, and how many patients suffer from joint diseases, pain in the spine ... Doctor in such cases are prescribed anti-inflammatory non-steroid drugs. Drugs of this group reduce pain, lower the temperature, remove inflammatory processes. They are used in many areas of medicine: therapies, orthopedics, gynecology. Among them are familiar to everyone "Analgin" and "Aspirin". Let's figure out what kind of non-steroidal anti-inflammatory drugs and how they act on the body.

The mechanism of action of the NSAIDs

Anti-inflammatory non-steroidal products (NSAIDs) are used in treatment: colds, spinal hernia, arthritis and arthrosis. The mechanism of action is based on the fact that the components included in their composition:

• loose any inflammatory processes;
• reduce swelling;
• reduce pain in any diseases;
• are antipyretic;
• blood diluted.

It is worth noting that non-steroidal anti-inflammatory drugs have a lot of contraindications. They are very annoyed by the mucous membrane of the stomach and duodenal gut, causing bleeding, appearance of ulcers. In addition, they contribute to the discharge of blood. Therefore, they are not recommended to accept:

• in the diseases of the stomach, duodenum;
• in case of poor blood clotting;
• during pregnancy;
• when allergic to the components of the drug.
• during hypertension exacerbation;
• with kidney disease, liver.

Classification of drugs

When meeting anti-inflammatory non-steroidal drugs (NSAIDs) it is important to know:

1. According to the power of pain relief, they are similar to narcotic drugs, but do not cause addiction.
2. They have a strong anti-inflammatory effect, but are not hormonal (steroid) drugs and do not lead to diseases associated with their application.
3. By influence on the body, they are divided into two groups: selective, non-selective. Both are widely used in medicine, but require applying strictly to appoint a doctor.

Selective

Selective NSAIDs are distinguished by the fact that they provide local electoral action on the inflamed area. They do not annoy and do not destroy the mucous membrane of the stomach, intestines, are produced in different types. The group of these drugs belongs:

• "Naz". Tablets, ampoules, gel. Used with inflammation of ligaments, after operations in gynecology, during dentistry in dentistry.
• "Movied". Injection, tablets, candles for the treatment of arthritis, osteochondrosis.
• "Celecoxib". Capsules with inflammation of the joints, bones.
• "Paracetamol". Tablets like antipyretic with a cold, fever.

Non-selective

The peculiarity of non-selective NSAIDs is that they inhibit inflammatory processes, while affecting the gastric mucosa and duodenum. They relate to the strongest drugs in the treatment of osteochondrosis, arthritis, their dosage and application are necessarily coordinated with the doctor. Among these drugs:

• Diclofenac in the form of tablets, ointments, injections.
• "Ibuprofen". Recommended for use of pregnant women.
• "Indomethacin". It acts effectively, but affects the gastric mucosa.
• "Ketoprofen". Several times stronger than ibuprofen, has contraindications.

Basic effects

What is nonsteroidal anti-inflammatory drugs? This is medical drugs that greatly facilitate the life of a patient with joint diseases, spine. Help with colds, fever, reducing the temperature. Improve the state after operations, change the quality of life arthrites, arthosis. The action is based on the fact that substances in their composition have a strongly pronounced analgesic effect. The most important thing is the NSAIDs actively inhibit inflammatory processes anywhere in the body. In addition, they are antipyretic and thinning blood.

Anti-inflammatory

The use of anti-inflammatory non-steroidal preparations was widespread in the treatment of diseases of the musculoskeletal system. Here osteochondrosis, arthritis, arthrosis, inflammation of connecting tissues, radiculitis. In case of acute form, treatment is starting with injections, then tablets are prescribed, and anti-inflammatory ointment, gels are used. Assign Diclofenac (the trade name "Voltaren", "Orthofen"), "Viprosal", "Bystremgel". The main point in the use of funds is the presence of a pronounced anti-inflammatory effect.

Antipyretic

Who did not take at elevated "aspirin"? Together with "Ibuprofen", "Nay", Paracetamol is a group of anti-inflammatory non-steroidal drugs with an antipyretic effect. They have greatly proven themselves in the treatment of colds, fever. Good results gives to reduce the temperature of Diclofenak, Ketanov, Analgin. When influenza disease, they are prescribed together with antiviral drug "Aziltomyrin". To facilitate the state of the patient, they are more often taken in the form of tablets or candles.

Anesthetic

Strong back pains, migraine, neuralgia, often do not give peace of rest during the day or night. It is difficult to fall asleep when the teeth sick or a sharp attack of gout. Renal colic, status after operations, Lumbago, Ishias, injuries - everything requires use for the anesthesia of the NSAID. They are used in the form of injections, tablets and ointments. Excellent indicators in such drugs as "Naz", "Naproxen", "Kathetonal", "Ketanov". They help with head dental, articular pains.

Indications for use

Group of non-steroidal anti-inflammation preparations are recommended for all sorts of diseases. It is difficult to imagine the area of \u200b\u200bmedicine where they are not used. It is important not to engage in self-medication, but to use them only to appoint a doctor. At the same time, it is necessary to follow the reception rules:

• read the instructions;
• pills, capsules drink plenty of water.
• eliminate alcohol, carbonated drinks;
• do not lie down after taking the capsule for better passing it;
• do not take at the same time several NSABS.

Orthopedists, traumatologists are used with chondroprotectors Non-steroidal anti-inflammatory drugs for the treatment of joints. They remove the swelling, reduce inflammatory processes, facilitate pain, allow you to move, improve the quality of life. First prescribe injections, then pills and nonsteroidal anti-inflammatory ointments. "Indomethacin", "Flexen", "Nimesulid" well shown themselves in the treatment:

• osteochondrosis;
• arthritis, arthrosis;
• coxarthrosis of hip joints;
• spinal hernia;
• radiculitis;
• gout.

In gynecology, these drugs are used to reduce monthly menstrual pains, facilitating the state after operations, reducing the temperature during complications. In obstetrics, the use of such a drug as "Indomethacin" contributes to the relaxation of the muscles of the uterus. Preparations are used as painting with intrauterine spiral removal procedures, endometrial biopsy. They help with uterine diseases, genitals. It is important to remember that their use creates a risk for the intestine, causing the appearance of ulcers, bleeding, and not engage in self-medication.

Prescribe drugs with colds with increased temperature, with neuralgia, dental inflammation, pain. Sports injuries, renal colic - everything is an indication for the use of nonsteroidal anti-inflammatory drugs. Thanks to the property of the NSABS, it is used for the prevention of infarction, strokes, such as antombose preparations that reduce the likelihood of blood blocking. In ophthalmology, drugs are used with inflammation of the vascular shell of the eye, and as an antiallergic in conjunctivitis.

For adults

Adult patients should not be engaged in self-medication. It is necessary to undergo a survey so that the doctor put an accurate diagnosis, prescribed the necessary funds. At the same time, it is important to take into account the age of the patient, allergic reactions to drugs. Many drugs have a huge number of contraindications for diseases. With caution to the use of nonsteroidal anti-inflammatory funds, it is recommended to treat pregnant women, elderly people. You should not take several drugs at the same time. Only the doctor will appoint the necessary tool and give the scheme of its application.

In the treatment of adult nonsteroidal anti-inflammatory drugs, it is necessary to take into account that each of the drugs has its duration of action. Depending on your disease, the state, you will appoint the use of medicines three times a day or one. There are 3 groups for the term:

1. A short. It continues from two to eight hours. Preparations: "Ibuprofen", "Voltaren", "Ortofen".
2. Average. Specifies from ten to twenty hours. Medicines: "Naproxen", "Sulindak".
3. Long. Duration of day. Preparation "Celloxib".

For kids

It should be used with caution to apply nonsteroidal anti-inflammatory drugs for the treatment of children. Many funds have unambiguous strict contraindications. Some drugs are limited by age. For example, "Aspirin" is not prescribed to 16 years. "Ibuprofen" and "paracetamol" are considered completely safe for the child. Pediatricians prescribe them even to breast children from 3 months. Apply at the time when children have a cold, the temperature, the teeth are cut. Since a small child is difficult to drink a medicine, it is prescribed in the form of candles.

List of non-steroidal anti-inflammatory means of a new generation

NSAIDs are not recommended for long-term use due to numerous side effects. Modern pharmacology Developed a group of drugs safe at constant reception. NSAIDs of the new generation do not cause complications, do not have dangerous contraindications. They act softly and selectively. These drugs include:

1. "Nimesulid". Reduces the temperature, treats back pain.
2. "Celecoxib". Helps with osteochondrosis, arthrosis.
3. "Movied". Prescribed against inflammation, with spine pain, joints.
4. "Ksefokam". The potent painkiller does not cause addiction.

The peculiarity of non-steroidal anti-inflammatory drugs of the new generation is that they do not irritate the mucous membrane of the gastrointestinal tract, do not cause bleeding, the appearance of ulcers. They only act on the inflamed, sore place. In addition, they do not destroy the cartilage tissue. Apply these means with an outpatient treatment, in a hospital. Side effects include:

• dizziness;
• drowsiness;
• increase pressure;
• shortness of breath;
• fatigue;
• indigestion;
• allergies.

Side effects

Anti-inflammatory non-steroid drugs are used in many areas of medicine, but it is necessary to take very carefully to their application. Do it only on the recommendation of the doctor who examined you because there are side effects:

1. The occurrence of ulcers and bleeding in the stomach, duodenalist.
2. Violation of the kidney function.
3. Problems with blood coagulation.
4. Allergic reactions.
5. The appearance of tissue necrosis during injections.
6. Liver lesion.
7. Problems with hearing, vision.
8. Dizziness, fainting.
9. Destruction of intra-articular cartilage.

Video about diseases under which NSAIDs are used

Check out the video, and you will learn how to make nonsteroidal anti-inflammatory drugs. Vitely see how they act on the inflamed place. You will learn how to avoid severe complications from the use of these drugs. Why it is strictly forbidden to drink them with carbonated drinks, and what food should be excluded from the diet during treatment.

There is practically no such disease in which non-steroidal anti-inflammatory funds (NSAIDs, NSAIDs) were not applied. This is a huge class of stole tablets and ointments whose source is ordinary aspirin. The most frequent indications for their use are diseases of the joints, accompanied by pain and inflammation. Our pharmacies are popular with both long-proven, well-known drugs and anti-inflammatory non-steroidal drugs of a new generation.

The era of such medicines began for quite a long time - from 1829, when salicylic acid was first discovered. Since then, new substances and dosage forms have been emerging, capable of eliminating inflammation and pain.

With the creation of aspirin preparations NSAIDs Allocated in a separate group of non-steroidal anti-inflammatory drugs. Their name determined that in its composition they do not contain hormones (steroids), and have less pronounced side effects than steroid.

Despite the fact that in our country most NSAIDs in pharmacies can be purchased without a recipe, there are some items that need to know. Especially to people who think that it is better to choose the years offered drugs, or modern NSAIDs.

The principle of the operation of the NSAID is the influence on the enzyme cyclooxygenase (COF), namely, on his two varieties:

1. COF-1 is a protective enzyme of the gastric mucosa that protects it from acidic content.
2. COG-2 - inducible, that is, a synthesized enzyme, which is produced in response to inflammation, or damage. Thanks to him, the inflammatory process is played in the body.

Since the non-steroids of the first generation are non-selective, that is, they also act on COF-1, and on COF-2, along with the anti-inflammatory effect, they have strong side manifestations. It is fundamentally important to take these tablets after meals, as they act annoyingly on the stomach, and can lead to erosion and ulcers. If there are already peptic stomach lesions, you need to take them with proton pump inhibitors (omeprazole, nonxium, controls, etc.), which protect the stomach.

Time does not stand still, nonsteroids develop, and are becoming increasingly selective for COX-2. Now there are currently medicines that selectively affect the COG-2 enzyme, on which inflammation depends without affecting COF-1, that is, without damaging the gastric mucosa.

About a quarter century ago there were only eight NSAID groups, but today they are more than fifteen. Woning wide popularity, nonsteroid pills quickly displaced opioid painkillers of analgesics.

Today there are two generations of nonsteroidal anti-inflammatory agents. The first generation is the NSAD drugs, mostly non-selective.

These include:

• Aspirin;
• Cititamon;
• Naproxen;
• Voltaren;
• Nooofen;
• Butadion and many others.

Nonteroidal anti-inflammatory drugs of a new generation are safer in terms of occurrence of side effects, and they have more expressed ability to remove pain.

These are such selective nesteroids as:

• Nimesil;
• Naz;
• Nimesulide;
• Kebrex;
• Indomethaxin.

This is not a complete list and not the only classification of a new generation NSAID. There are their separation on non-acid and acid derivatives.

Among the NSAIDs last generation The most innovative drugs are oxicams. These are non-steroidal anti-inflammatory drugs of a new generation of acid-acting group, affecting the body much longer and brighter than others.

This includes:

• Lornoksikov;
• Pyroxics;
• Meloxicam;
• Thosexico.

The acidic group of drugs includes the following series of nonzeroids:

To non-acid, that is, non-affecting the gastric mucosa means include the NSAID of the new generation of the group of sulfonamides. Representatives of this group - "Nimesulid", "Ropekoxib", "Celloxib".

A wide application and the popularity of the new generation NSAID won due to their ability not only to remove pain, but also have an excellent antipyretic effect. Preparations will focus the inflammatory process, diseases do not develop, so they are prescribed when:

• Muscular tissue diseases. Nonteroids are used to treat injuries, wounds, bruises. They are indispensable in arthrosis, arthritis and other diseases of rheumatic nature. Also, with the hernias of intervertebral discs and myosites, the tools have an anti-inflammatory effect.
• Strong pain syndromes. Success is successfully used in the postoperative period, with biliary and renal colic. Tablets have a positive effect with head, gynecological pains, successfully remove pain in migraines.
• Risk of blood clots. Since non-steroids are antiagregant, that is, we have diluted with blood, they are prescribed during ischemia, and for preventing strokes and heart attacks.
• High temperatures. These pills and injections are the first antipyretic agent for adults and children. They are recommended to be used even with feverish states.

Means are also used for gout and intestinal obstruction. For bronchial asthma It is not recommended to use NVPP independently, a preliminary consultation with the doctor is necessary.

Unlike non-selective anti-inflammatory funds, the NSAIDs of the new generation do not have an irritant action on the gastrointestinal system of the body. Their use in the presence of ulcers of the stomach and duodenum does not lead to exacerbation and occurrence of bleeding.

However, their long-term use can cause a number of unwanted effects, such as:

• increased fatigue;
• dizziness;
• dyspnea;
• drowsiness;
• destabilization of blood pressure.
• appearance in the urine of protein;
• indigestion;

Also, during long-term reception, the manifestation of allergies is possible, even if there were no previous susceptibility to any substances.

Non-selective nesteroids, such as "ibuprofen", "paracetamol" or "diclofenac" have greater hepatotoxicity. They are very strongly affected by the liver, especially Paracetamol.

In Europe, where all NSAIDs are prescription, in the large go of a non-receptive paracetamol (taken as an anesthesia to 6 tablets per day). There appeared such a medical concept as "paracetamol damage to the liver", that is, cirrhosis against the background of taking this medication.

A few years ago, a scandal broke out abroad for the influence of modern nesteroids - cocksibs on the cardiovascular system. But our scientists did not divide the concerns of foreign colleagues. The domestic association of rheumatologists act as opponent Western cardiologists, and proved that the risk of heart complications against the backdrop of a new generation NSAID is minimal.

It is absolutely impossible to use most anti-inflammatory nesteroids during pregnancy, especially in the third trimester. Some of them can be appointed by a doctor in the first half of pregnancy under special testimony.

By analogy with the NSAID antibiotics of the new generation, it is impossible to take too short courses (2-3 days I drove and stopped). It will be harmful because in the case of antibiotics, the temperature will go, but the pathological flora will acquire resistance (stability). The same thing with Nesteroids is to take them at least 5-7 days, as pain can leave, but this does not mean that the person recovered. Anti-inflammatory action occurs a little later anesthetic and flows slower.

1. In no case do not combine non-steroids from different groups. If with pain in the morning, drink one tablet, and then another, their useful action is not summed, and does not increase. And side effects increase in geometric progression. It is especially possible to combine heart aspirin (aspirin-cardio, cardiomagnet) and other NSAIDs. In this situation, the danger of cardiac attack arises, as the action of aspirin, diluted blood, is blocked
2. If some joint hurts, start better with ointments, for example, based on ibuprofen. They need to be used 3-4 times a day, especially for the night, and intensively rub into a sore place. You can make self-massage sick place with ointment.

The main condition is peace. If you continue in the treatment process to actively work or play sports, the effect of drug use will be very few.

The best drugs

Having come to the pharmacy, each person thinks that non-steroidal anti-inflammatory drugs choose, especially if he came without a doctor's prescription. The choice is huge - nonsteroids are produced in ampoules, tablets, capsules, in the form of ointments and gels.

Tablets are the greatest anti-inflammatory effect - derived acids.

Good painkillers for diseases of the musculoskeletal tissue have:

• Ketoprofen;
• Voltaren or diclofenac;
• Indomethacin;
• Ksefokam or Langnocks.

But the strongest means against pain and inflammation are the latest selective NSAIDs - Koksibi, which have the least side effects. The best non-steroidal anti-inflammatory drugs from this series - Arkoxy, Naz, Molovas, Celloxib, Ksefokam, Economic and Kenetsib.

Ksefokam

Analogue tools are Langnoksikov, Rapid. Active substance - Ksefokam. Effective medicine with a pronounced anti-inflammatory effect. Does not affect the heart rate arterial pressure and breathing frequency.

Produced in form:

• tablets;
• ukolov

For patients of old age, special dosage is not required in the absence renal failure. For kidney disease, the dose must be reduced, since the substance is derived by these organs.

Under the excessive duration of treatment, manifestations are possible in the form of conjunctivitis, rhinitis and shortness of breath. With asthma, used with caution, since an allergic reaction is possible in the form of bronchospasm. With the introduction of an injection, soreness and hyperemia at the injection site are possible.

The preparation of the Arkoxy or its one is an equivalent examples used in acute gouty arthritis, osteoarthritis of rheumatoid type, and in the treatment of postoperative states associated with pain. Produced in the form of pills for oral administration.

The active ingredient of this drug is designers, which is the most modern and safe substance among selective inhibitors COF-2. The remedy will greatly stop pain, and begins to act on the pain bar after 20-25 minutes. The active substance of the drug is absorbed with blood flow and is distinguished by high bioavailability (100%). Examined with urine unchanged.

Nimesulid

Most specialists of sports traumatology are distinguished by such a nesteroid, as nims or its analogues of Nimille or Nimulide. Names there are many but active substance They have one - Nimesulid. This medicine is quite cheap, and takes one of the first places on sales.

This is a good analgesic drug, but nimesulide-based funds can not be used for children under 12, since the likelihood of occurrence allergic reactions.

Available in the form:

• powders;
• suspensions;
• gels;
• tablets.

It is used in the treatment of arthritis, arthrosis, in diseases of Bekhterev, sinusitis, lumbago, and pains of various location.

Molovas is much more selective to COX-2 than the Naz, and, accordingly, with respect to the stomach, there is even fewer side effects.

Release form:

• candles;
• pills;
• shots.

For long use Increased risk of developing heart thrombosis, heart attacks, angina. Therefore, people with predisposition to these diseases are required to be taken care. It is also not recommended for women planning pregnancy as affects fertility. Displays in the form of metabolites, mainly with urine and feces.

Kesetoxib

In the group with the most proven base in terms of security - the NSAID of the new generation of celecoxib. It was the first drug from the group of selective koksibov, which combines three strengths of this class - the ability to reduce pain, inflammation, and sufficiently high security. Release form - Capsules of 100 and 200 mg.

The current component of the celecoxib selectively acts on COX-2, without affecting the gastric mucosa. Quickly absorbed into the blood, the largest concentration of the substance reaches 3 hours after 3 hours, but the simultaneous reception with fatty food can slow down the absorption of the drug.

It is prescribed celecoxib under the or rheumatoid arthritis, osteoarthritis and ankylosing spondyloarthritis. This agent is not prescribed during liver and renal failure.

Ropecoxib

The main substance of ropecoxib effectively helps restore the motor function of the joints, quickly removing inflammation.

Available in the form:

• injectable solutions;
• tablets;
• candles;
• gel.

The substance is a highly selective cyclooxygenase inhibitor 2, after receiving a quickly rested by the gastrointestinal tract. The maximum concentration in the blood substance reaches after 2 hours. It is removed mainly in the form of inactive metabolites with kidneys and intestines.

The result of long-term reception may be disorders from the nervous system - a sleep disorder, dizziness, the impertness of consciousness. Treatment is recommended to start with injections, then switch to tablets and external means.

When choosing any NVPS, not only the price and their modernity should be guided, but also to take into account the fact that all such medicines have their own contraindications. Therefore, it should not be engaged in self-medication, it is best if they are appointed a doctor taking into account age and the presence of diseases in history. It should be remembered that the mindless use of drugs can not only bring relief, but also make a person treat many complications.

What is NVPS drugs? These are non-steroidal anti-inflammatory drugs (NSAIDs, NVPS), which are able to stop inflammation, pain and heat. Preparations from the NSAID group block specific enzymes, the function of which is the formation of prostaglandins - compounds that cause inflammatory processes, feverish conditions and pain.

NSAIDs are nonsteroidal drugs, it means that they do not contain in their composition steroid hormones or their artificial analogues.

The origins of nonsteroidal anti-inflammatory drugs go to a very distant past. Another famous hippocrate was offered to use Crara Willow as an analgesic agent, and at the beginning of our era Celsius stated that the Cara Willow could really paint the articular pain and even take signs of the inflammatory process.

Then, about this agent was forgotten for many years, and only in the 18-19th century, scientists were able to extract from the bark. It was Salicin, who became the predecessor of those drugs that we use now, and then to get 30 grams of substances, the scientist had to recycle about 2 kilograms of the Willow Corn.

In the middle of the 19th century, salicylic acid was obtained - a slicin derivative, but it turned out quickly that it causes strong harm to the gastric mucous membrane. Scientists with new forces began to conduct experiences and look for new substances. By the end of the 19th century, German scientists were opened a new era in pharmacology - they were able to turn a strong toxic experiments through numerous experiments and experiments. salicylic acid and safer acetylsalicyl. It was aspirin.

For a fairly long time, Aspirin was the only representative of a group of non-steroidal anti-inflammatory drugs, but in the middle of the last century, pharmacists and chemists began to synthesize all new and new funds, and each next was safer, and at the same time, the previous one.

The mechanism of work of drugs

Inflammatory reaction B. human organism - This is a chain of reactions that run each other. Prostaglandins are involved in this process, and they have a negative inflammatory effect, but also take part in the protective factors of the gastric mucosa. That is, there are two types of COF-1 enzymes and COF-2. The first is "inflammatory", which in a healthy body remain in inactive form, and the second - the "protective" enzymes of prostaglandin synthesize. The mechanism of action of the NSAIDs is directed to them, the drugs depress the enzymes of COG-2, but at the same time also violate the barrier protection of the stomach is side effects.

In addition, non-steroidal anti-inflammatory drugs are actively affected by cellular metabolism, as a result of which there is an anesthetic effect, the side effects are also due to the use of drugs - inhibition, apathetic, lethargy.

When the tablets of non-steroidal anti-inflammatory drugs fall into the human body, they, as a rule, dissolve and absorbed in the stomach, and only a minor part is absorbed in the intestine. The level of absorption in drugs is poured if it is a means of the last generation, it can be 95%, and the drug in a special shell dissolving in the intestines is absorbed much worse, such as aspirin-cardio.

The metabolism of drugs occurs in the liver, this explains the side effects and the impossibility of receiving the NSAID in the pathologies of this organ. Only a relatively small part of the dose of the drug is excreted by the kidneys. Scientists are constantly looking for methods for reducing the toxicity of the NSAIDs of drugs for the liver, and also try to reduce their effect on the COX-1 enzyme.

Classification of medicines

The classification of the NSAIDs is based on the principle of their actions, in connection with this distinguish selective NSAIDs and non-selective. If you understand the terms, then selectivity is the ability of the drug to influence selectively, those are therapeutic effect It turns out relative to a certain link of the general pathological process. Selective NSAIDs block COG-2, and have an impact only on COF-1.

Selective, as well as non-selective NSAIDs - this is, in principle, almost all drugs of this group, but there are still selective NSAIDs COG-1 inhibitors. This small group of funds, its example there may be low dosage acetylsalicylic acid.

If we talk about the list of NSAIDs, there are quite a few drugs on the market on the market, today it is 15 subgroups, so the complete list of NVPS will be impossible to lead within this article. However, it can be said that drugs are classified into two main groups:

• the first generation is a voltar, aspirin, ibuprofen, diclofenac, methadanol, butadion and other;
• new generation - Naz, Kebrex, Nimille and so on.

There is another classification of NSAIDs:

• salicylates - an example - aspirin;
• phenylacetic acid - an example - diclofenac;
• pirazolidin - an example-compere-band;
• anthranyl acid - an example - a mefenaminate;
• propionic acid - an example - ibuprofen;
• isonicotic acid - an example - Amizon;
• pyrazolone derivatives - an example - analgin;
• oxycams - example - pyroxics;
• non-acid drugs are an example -Nmesulide.

This list includes the most famous drugs, but in each group of their dozens. Summing up the classification of the NSAID, it is impossible not to say about the comparative classification of funds:

• the pronounced anti-inflammatory effect is observed, for example, in Indomethacin;
• ketoprofen is well anesthetics;
• reduces the temperature is better than hors, nourofen or aspirin.

Many trade names medicinal preparations may differ, so buying drugs, you need to pay attention to the active ingredient, and not the name.

Scope of application

In the medicine of the present time, the use of these drugs is very diverse. Tablets are prescribed to knock down the hanged temperature and to relieve pain syndrome to remove heat in children, most often prescribe candles. If the patient's condition is severe may be required injecting, ointments and gel with NSAIDs are prescribed to remove the inflammatory process in the joints, in the spine, to remove the pain symptom at edema and inflammation. If articular diseases are treated, then pills and injections can be combined, and ointment can be used as additional therapy.

So, the fields of application of the NSAID look like this:

• rheumatic diseases - pills, injections, ointment;
• diseases of the bone-articular apparatus, which have no rheumatic character - tablets, injections, gel;
• neurological diseases - tablets;
• colic (both hepatic and kidney) - tablets, injections;
• inflammatory diseases in acute form - pills, injections;
• ischemic heart disease - tablets;
• gynecological problems - tablets;
• pain syndrome of any etiology - pills, injections, ointment.

Side effects

The NPBS has a lot of side effects, so before you start their reception, it is necessary to read a sheet of liner, and find out what can take the reception of these drugs.

The most common side effects are as follows:

• preparations can provoke ulcerative ulcer of the stomach, as well as intestines, or to exacerbate the existing disease;
• they can cause various dyspeptic phenomena;
• quite often, the NSAID disrupts the functionality of the nervous system.
• we provoke allergies.

Such side effects can with a high frequency to occur when using tableted form of drugs, as well as injections and suppository. Ointment, injections that are introduced into the joint, as well as a non-steroid anti-inflammatory gel of such effects do not give.

In addition, there is another group of side effects that can cause NSAIDs - influence on blood formation. Preparations have a rather strong blood thinning effect, so it must be taken into account patients who have problems with blood, otherwise you can very seriously undermine health. An even more dangerous is the fact that the NSAID oppresses the blood formation processes, the number of blood elements is reduced, which leads to dangerous consequences. Initially, anemia develops, after this, thrombocytopenia may appear, and in the end - pancytopenia.

Other side effects can be studied in detail in the liner sheet, which is available to each drug. Do not think that ointment, candles, cream or gel are safer. And these forms of drugs have side effects, so consultation with a specialist is obligatory anyway.

NVPS gastropathy

NVPS-Gastropathy is ulcers formed in the gastroduodenal zone as a result of taking drugs of a non-steroidal anti-inflammatory group. NVPS-Gastropathy in half cases flows without any symptoms, but if they are, then they are manifested in nausea and vomiting, in the bloating of the abdomen and the feeling of gravity in the epigastric area. Anorexia or some other dispersal disorders may develop.

In the absence of symptoms of the NSAIDs - gastropathy is even more dangerous, since the first signs of the problem can become bleeding, such a phenomenon is often observed in patients of old age.

If NSPIDs gastropathy originated, then you need to immediately cancel the reception of the drug, and then act on the recommendations of the doctor. Most often IIP is prescribed, or histamine blockers.

NSAIDs-gastropathy is treated for a long time - about 2-3 months, so patients prone to the development of ulcerative disease (or already having it) NSAIDs are prescribed very carefully - either choose drugs with low toxic dosage, or it is recommended to use gel, injections and tablets in intestinal soluble shell.

Contraindications for use

Mostly it concerns NSAID tablets. Contraindications are associated with "whites" of drugs. NSAIDs do not write down to people who have ulcerative disease of the stomach and intestines, especially in a sharp period. We also take the preparations are contraindicated to people suffering from blood diseases - problems with coagulation, anemias, leukemia and leukemia.

Preparations are not prescribed simultaneously with the means that worsen blood clotting, for example, heparin, as well as the same NSAIDs can not be taken simultaneously, even in different formsSince it can strengthen side effects. This is especially true of the funds, which contains diclofenac or ibuprofen.

Often, the reception of drugs provokes the development of non-specific allergic reactions, and the intensity of allergic manifestations has no connection with what exactly dosage form NSAIDs applied. Allergies with equal frequency occurs when taking a tablet, and when using ointments, and when injections. The aspirin asthma is very dangerous - it is severe attack, which can develop when taking a drug containing aspirin. Allergies need to be sure to test before using the drug, and if it is a tablet for form, then start receiving with a minimum dose.

Non-steroidal anti-inflammatory drugs are essential drugs for the treatment of joints. They are able to provide symptomatic help: to remove pain syndrome, lead the body temperature to normal, relieve inflammation. This is especially important with such a spine pathology as osteochondrosis. After all, with the exacerbation of the disease, a person feels not only strong back pain, but the inability to fully move is that in the future can lead to disability. Even during the remission, many patients note reduced muscle tone and increased fatigue. In order to facilitate the symptoms of the disease and there are nonsteroidal anti-inflammatory agents and drugs (NSAIDs and NSAIDs).

Mechanism of action

Non-steroidal anti-inflammatory facilities are the preparations of a new generation. The principle of their action is based on the blocking of activity cyclooxygenase. These enzymes provoke an inflammatory process in abnormal foci of mediators, which leads to extension of vessels and occurrence pain sensations.

The enzymes of the cyclooxygenase group exist in the human body itself and have two isomeric forms:

• COF-1 is actively involved in the production of substances necessary for normal operation internal organs. In particular, it protects the gastric mucosa from of hydrochloric acidwhich is contained in gastric juice. Therefore, the blocking of COG-1 may lead to the appearance of gastritis, gastric bleeding and ulcers.
• COG-2 can be found only in the area of \u200b\u200bthe body where inflammation is present. That is why NSAIDs, blocking this form of enzymes, can eliminate pain syndrome and remove the inflammatory process.

In order to choose non-steroidal anti-inflammatory drugs, you need to consult a doctor. Only a specialist who has the results of your analyzes in his hands and knowing all clinical picture your diseases may pick up proper medicine And the desired dosage.

Assign independently such serious medicines in the form of injections, injections in ampoules, tablets or ointments for the treatment of arthrosis and chondrose stricter is prohibited. Similar amateur may be dangerous for your health.

Classification: Best Review Review

Most often for the treatment of osteochondrosis doctors prescribe modern drugs, in which there are diclofenak (Voltaren, Ortofen, Dicloran, Diclac, etc.). This medicine, created in 1966, has perfectly proven itself in the fight against inflammation and painful syndrome. The indisputable plus of this nesteroid is that it can be combined with analgesics, thereby improving their action.

But diclofenac has a number of contraindications: it cannot be taken to children, pregnant women and patients with ulcerative disease.

For selective anesthesia, the desired body area can also be assigned the following drugs Internal action:

• Nimesulid - Nonteroid preparation from the class of sulfonanildes. It is able to inject COX-1 to a small degree, while it has a well-pronounced antioxidant effect. This medicine is often used to remove pain syndrome, but it can cause nausea, increased drowsiness, headaches. The drug is also prohibited by the use of women in the position, children under 18 and those who suffer from ulcer.
• Naproxen- drug from the group of naphthyl-propionic acid derivatives. It is widely used in the treatment of spinal diseases, as it reduces the pain and eliminates inflammation. It has the same contraindications to use, as well as nimesulide.
• Indomethacin - a drug internal applicationwhich is an indoletaceous acid derivative. It copes well with pain syndrome and inflammatory process, but can provoke the development of diseases of the gastrointestinal tract. This medicine can not be used to children under 6 years old, pregnant women, mothers in the period breastfeeding.

Medicines outdoor use

To reduce the swelling, eliminating the local inflammatory process and pain often use external anti-inflammatory drugs:

• Indomethacin (ointment). This non-steroidal drug is able to quickly save you from pain and edema. Reduced inflammation You will already feel during the first week of application. Most often, this medicine is discharged in the inflammatory process in the joints and soft tissues, as well as with pain in the spine. The drug has a number of contraindications: childhood, pregnancy and period of breastfeeding, liver disease and stomach, problems with blood formation.
• Ibuprofen. (gel) is a non-steroidal anti-inflammatory agent aimed at fighting edema, hyperemia and pain. It is often prescribed during osteochondrosis, as special contraindications, in addition to the intolerance of the components of the drug, he does not have.
• Ketoprofen. (ointment, gel). This drug is prescribed with acute pain for removing pain, reducing swelling and temperature. It can not be used patients with diseases of the gastrointestinal tract and liver, children and pregnant women.
• Butadion (ointment) are often discharged to combat cervical osteochondrosis. This drug is used locally; It removes inflammation, reduces swelling, eliminates pain. It can also be used to remove pain in the joints of feet and arms, lower back, knee and locks Sustava. To achieve the effect, the ointment is applied by a thin layer on the focus of inflammation within 10 days. From side effects, the following are the following: eczema, peeling, itching, edema. The means is contraindicated to the use of pregnant women in the first and third trimester.

Terms of application

Non-steroidal anti-inflammatory tools have quite a lot of side effects, so it is necessary to take them with caution, observing certain rules:

1. Anti-inflammatory pills need to be used after eating, drinking with a small amount of water. This is due to the fact that they can have a negative impact on the work of the stomach and liver.
2. The diagram and duration of treatment cannot be extended by you individually, without approval of the doctor. Overdose can provoke negative organism reactions;
3. Even local outdoor use drugs can provoke the development of gastritis, so ointments and gels need to be dispensed clearly by instructions;
4. In parallel, the use of NSAIDs is often assigned to the reception of Almaty to protect the gastric mucosa from the effects of nesteroids;
5. Assign the reception of the NSAID can only a doctor.

Contraindications and side effects

Non-steroidal anti-inflammatory agents are sufficiently strong drugs, it is necessary to relate to their reception. It is not surprising that they have an impressive list of contraindications to use. Even more good medicine It may harm if you use it incorrectly and without appointment by a specialist.

Therefore, if you do not want to encounter negative consequences when taking the NSAID, you first specify whether it is possible to use it.

Most often, the following restrictions meet in the list of prohibitions:

• diseases of the kidneys and liver - how acute formsand chronic;
• gastritis, colitis, peptic disease are contraindications for taking NSAIDs in the form of tablets and injections. With these diseases, the use of suppositories (candles) is recommended;
• the pathologies of the rectum, in turn, prohibit the reception of nesteroids in the form of candles - in this case, shots and tablets are shown.

The most safe nesteroids are considered ibuprofen and paracetamol. Their use can be appointed even children of the olden age. As for the possible side effects when taking other anti-inflammatory means, it is worth noting the possibility of the appearance of leukocytosis. Therefore, when appointing the NSAID, it is important to regularly pass blood tests to prevent a critical reduction in the number of leukocytes.

To prevent the development of diseases of the gastrointestinal tract when taking non-steroidal drugs, it is important to observe therapeutic diet. You can also encounter such unpleasant consequences as diarrhea, headache, allergic, tendency to bleeding, abdominal pain, swelling, drowsiness. When the first side effects appear, it is necessary to immediately consult a doctor to pick up you another drug.

Conclusion

The pain syndrome in diseases of the spine and joints delivers many inconvenience and unpleasant moments to patients. It is not necessary to endure pain - this is the body of the body that it needs your help and attention. Anti-inflammatory drugs of the new generation are able to significantly alleviate the state of the patient, so it is not necessary to fear their use. Their main goal is to anesthetize, reduce inflammation, reduce swelling. The main thing is to do everything with permission and under the control of the doctor, and then the NSAID will become your reliable assistants in the fight against the disease.

Non-steroidal anti-inflammatory funds (NVPS): principle of operation, indications, contraindications, side reactions from use. Natural anti-inflammatory funds.

What does Nesteroid funds mean?

For our body, all non-steroidal anti-inflammatory agents are alien substances. The human body has its own anti-inflammatory system, which is started in case of severe injuries or stress. The main anti-inflammatory effect in the human body is carried out by a number of steroid hormones of adrenal glands (gluchicorticida), the synthetic analogs of which are used in the manufacture of hormonal anti-inflammatory drugs.
The term "Nesteroid" means that medicines from the NSAID group do not belong to the group of steroid hormones and are deprived of a number side effects Specific for drugs from this group.

In what cases use non-steroidal anti-inflammatory funds?

As antipyretic drugs, nonsteroidal anti-inflammatory drugs are used for:

• Treatment of temperature, against the background of various diseases in children and adults

As anti-inflammatory drugs, the NSAIDs are used to treat:

• Diseases of the musculoskeletal system (arthritis, osteochondrosis, the hernia of the intervertebral disc, mositis, with injuries and stretching)

As an anesthetics, nonsteroidal anti-inflammatory drugs are used in treatment:

• Migraines and other headaches, pain when menstruation and some gynecological diseases, in the treatment of bile or renal colic, etc.

As an angihagregant, non-steroidal anti-inflammatory drugs are used to treat:

• Ischemic heart disease, infarction and stroke prevention.

In what cases can not be used non-steroidal anti-inflammatory agents?

Nonteroidal anti-inflammatory funds cannot be used in the following cases.

• Patients with ulcerative gastric and duodenal disease
• Patients with increased sensitivity to these drugs
• During pregnancy or breastfeeding, without observing the doctor.

Side effects of nonsteroidal anti-inflammatory drugs

The most dangerous side effects from the use of non-steroidal anti-inflammatory are associated with their action on blood and gastric mucosa.
The adverse effect of nonsteroidal anti-inflammatory drugs on the human body is explained by the fact that they block the production of prostaglandins not only in the focus of inflammation, but also in healthy organs and blood cells. In healthy tissues, in particular in the gastric mucosa, prostaglandins play an important protective role (protection of the stomach tissues from the aggressive effects of acidic gastric juice), therefore the use of non-steroidal anti-inflammatory drugs contributes to the appearance of the stomach and duodenal ulcers. By blocking the production of prostaglandins in blood cells, non-steroidal anti-inflammatory drugs reduce blood reducingness, which can be dangerous in people with a high risk of bleeding.
Less dangerous side effects of nonsteroidal anti-inflammatory drugs are associated with the possibility of developing allergies and with their annoying effect on gastrointestinal (nausea, vomiting, abdominal pain, bloating).
Before using any of the drugs from this group, carefully examine the list of contraindications and side effects.

Natural (natural) anti-inflammatory funds

The use of nonsteroidal anti-inflammatory drugs in medicine began with the discovery of such properties in some natural products. In particular, it was noted that there is a substance of salicyllate in the extract, which has a strong anti-inflammatory and antipyretic effect. Later, on the basis of salicyllate, one of the most famous of modern drugs - acetylsalicylic acid or aspirin was synthesized.
In traditional medicine, some other means with antipyretic and anti-inflammatory effect are known. Here is some of them:

• Raspberry jam and tea from raspberry branches - reduces the temperature and inflammation against a cold background
• Infusion of chamomile or calendula - have a strong anti-inflammatory and antimicrobial effect with local use

In addition to folk anti-inflammatory funds, pharmacological and homeopathic medicines made on the basis of natural raw materials are available: Rume-gel, sabelnik tincture, etc.

Ankylosis (ICD) is a disease that starts with mobility disorders (contractures) and leading over time to complete immobility of the joints. The ankylosis of the joint is not a separate disease, but the symptom of other pathological changes. The disease is striking both large and small joints (fingers and legs)

Arachnoiditis is the inflammation of the cute shell of the head or spinal cord. This pathology accounts for about 5% of the total organic lesions nervous system. As a rule, the arachnoiditis is diagnosed in patients under the age of 40 years (it can often be detected in a child).

Benzidamine hydrochloride is a non-steroidal anti-inflammatory agent, an indazole derivative, without a carboxyl group. Has an anti-inflammatory and local painkillers, has antiseptic (against wide spectrum Microorganisms), as well as antifungal action.

Acetylsalicylic acid belongs to the NSPV, that is, a group of non-steroidal anti-inflammatory funds. Her main therapeutic effect - It is anesthesia, removal of feverish state, blood dilution, by braking the platelet aggregation process.

Sulfasalazine refers to the means that are used in systemic pathologies of an inflammatory nature, as well as non-specific diseases. It has an immunosuppressive effect on the body, due to the fact that inhibits autoimmune reactions. That is why it is used in therapy rheumatoid arthritis and other systemic diseases.

Salicyl ointment - This is a very effective non-steroidal anti-inflammatory drug, which is intended exclusively for local outdoor use. This drug is widely used in the course of therapy of various leather pathologies.

Nimide is a drug from the classic NSAID group (non-steroidal anti-inflammatory drugs with a soft anti-inflammatory effect. It is used for various inflammatory diseases with pain syndrome (inflammatory diseases of the nasopharynx, throat, postoperative pains, during sports injuries.