All antibiotics should be applied only by appointment of a doctor. Assigning cefazoline, the doctor indicates which dosage and through what time intervals should be injected. By making an appointment, the doctor believes that the injection will be a nurse and therefore usually does not explain how to breed cefazolin. But in practice, in many cases of injections, we perform our relatives or neighbors who may not have this information.

0.5% or 1% solution of novocaine, 1% solution of lidocaine or water for injection is used to breed cefazoline. For intramuscular administration, cefazoline is diluted with water only in the case of individual intolerance to the patients with solutions of lidocaine and novocaine.

For intravenous administration Cefazoline is divorced by isotonic solutions, for example, 5% glucose solution or 0.9% sodium chloride solution.

How to breed cefazolin novokain

An adult for one injection is usually prescribed 1.0 g. In this case, 5.0 ml is recruited into the syringe. 0.5% - 1% novocaine solution. A protective foil is moved from the bottle. The rubber lid is carefully processed with a cotton swab dipped in alcohol. Novocaine is introduced inside the bottle with cefazolin. After that, the bottle shake several times to completely dissolve the preparation and the resulting solution is gained into the syringe.

Cefasoline Children: how to breed

Cefasoline children are usually assigned at the rate of 25 - 50 mg. per kilogram body weight. For heavy infections The doctor can increase the dose of up to 100 mg. On kg mass body weight. For example, your child has a body weight of 8 kg., And the doctor prescribed cefazoline to him at 400.0 mg. How to breed cefazoline in this case? It is best to buy bottles containing 0.5 g. 5.0 ml is added to the vial. Novocaine. As a result, we obtain a solution of an antibiotic containing in 1.0 ml. 100.0 mg. Drug. Because We need to perform 400.0 mg injection. Cephazolina, then in the syringe should be scored 4.0 ml. The resulting solution. Similarly, the drug is produced and in another packaging, for example, 1.0 g. Only not 5.0 ml should be used for children., And 10.0 ml. novocaine solution.

Diseases caused by various microbes and infections have been greatly distributed. Therefore, today they became very popular special drug drugs based on antimicrobial properties.

Composition and form of release

To such special medical agents Refers cefazoline. Indications for the use of this drug apply to a wide range of bactericidal and antimicrobial effects. Cephazoline includes sodium cefazoline, which is a semi-synthetic cephalosporin antibiotic for the first generation. This medication medicine Produced as a white powder for the manufacture of a special solution for injections.

Principle of operation of the drug

Cefazoline actively reacts to gram-positive and gram-negative microorganisms, has resistance to antibiotics, does not affect the rickettsia and other simple viruses. This is a drug like a famous penicillin, easily destroys the synthesis of the cell wall of bacteria. The important property of the cephazoline medication is not ignored, due to the rapid absorption of the drug. Almost 90% of the received medication binds to proteins in blood plasma.

When using cefazolin, indications for use this drug It is noted that after intramuscular administration, the maximum drug concentration is achieved within an hour, and after intravenous injection - almost immediately. Cephazoline has the ability to easily penetrate the tissue through the synovial shell in the joints. The special value of the use of this drug is that the therapeutic concentration of the medication is maintained in the blood of a person for almost 8 to 12 hours.

Indications for use

Doctors specialists are quite often prescribed cefazoline, indications for the use of which indicate its unique pharmaco-kinetic features. First of all, cefazoline is intended for the treatment of numerous infections caused by pathogenic gram-negative and gram-positive microorganisms sensitive to this preparation. The main indications for the use of the drug Cefazolin are infectious diseases of the respiratory tract, such as bronchitis, infected bronchiectases, bronchopneumonia, bacterial. This medicine is used to treat postoperative infections of the chest, abscesses of light, tonsillitis, middle otitis, other diseases of the ENT organs of the same nature.

Also in infections of the urogenital system, cefazoline helps remarkably. Indications for the use of this drug are directed to effective treatment diseases such as acute and chronic pyelonephritis, prostatitis, urethritis, cystitis. Infectious diseases of the skin, soft tissues, including cellulite, mastitis, corrosive inflammation, infected with gangrene, burn, wound and postoperative infections are also indications for the use of cefazolin. Use this medicine in ophthalmology with infections of eye tissues. Cephazoline is shown to use for treatment infectious diseases bones and joints, including septic arthritis, osteomyelitis.

This drug has been widely used in gynecology, in particular, in obstetrics. The injections of cefazoline are used, uterine infections, pelvic abscesses, salpingitis. People without injection of this drug in the treatment of venereal diseases - syphilis, gonorrhea. Surgeons doctors know that the preoperative purpose of the drug Cefazolin helps effectively reduce the incidence of postoperative infections. As a rule, the injections of cephazoline are carried out inkjet or drip, intravenously or intramuscularly. The necessary dosage is prescribed only attending physician.

Contraindications

Cephazolin with its own high efficiency It has certain contraindications. Cefazoline is contraindicated with a hyper of sensitivity to the antibiotics of the cephalosporine row, with not the perception of other beta-lactam antibiotics, during pregnancy. Little children under the monthly age, Cephazoline are prescribed only in case of extreme need.

It is believed that the drug cefazolin has enough high degree security. However, despite this, the reception of any medicinal product, especially the antibiotic, requires a mandatory advice from a qualified specialist doctor. Any self-medication threatens with dangerous complications. Observe the principle of rationality, never use drugs yourself. Good health!

Cephazolin is medical preparationAntimicrobial action. He found its use in pediatrics, in particular, in the hospital in terms of the child's placement in the infectious office.

Cefasoline: Indications for use

Cephazolin is the strongest antibiotic, capable of causing strongest adverse reactions. Therefore, it is used in the most extreme cases with such diseases as:

• diseases of the small pelvis;
• skin diseases, soft tissues;
• diseases bone system and joints;
• infections of the urogenital system;
• infections of the upper respiratory tract (bronchitis, bronchiectase, bacterial pneumonia, lung abscess, tonsillitis);
• sepsis;
• endocarditis;
• medium otitis;
• peritonitis;
• osteomyelitis;
• burn infections;
• postoperative infections.

This drug is quite efficient, because it has a long life on the body (up to eight hours).

Cephazolin Children: Dosage

Daily dosage in childhood is no more than 40 mg per kilogram of the child's weight. In the event of a severe course of the infectious disease in particularly emergency cases, 100 mg per kilogram of weight is possible. The full course of treatment is ten days.

The medicine is injected in 4 receptions.

In case of overdose, seizures, vomiting and tachycardia are possible.

How to prick cefazolin to children?

Cephazoline is prescribed in injections both intramuscularly and intravenously.

With intravenous administration of cefazolin, it is necessary to breed it with a special solution for injections. Injections for buttocks are bred by novocaina or lidocaine. It is not recommended to breed children with novocaine medicine, because with this method of administration is possible allergic reactions.

After injection, it is necessary to carefully monitor the state of the child, therefore, it is most advisable to carry out a course of treatment with cefazolin in a hospital.

Cefasoline: How to breed children?

For cefazolin dilution, it is necessary to purchase vials of 0.5 grams of the drug substance and 5 ml of 1% novocaine solution. For example, at a daily dosage of 400 mg 1 ml of the resulting solution contains 100 mg of cefazolin. Accordingly, in the syringe it is necessary to introduce 4 ml of the cefazoline solution with Novocaine.

With the use of vials of 1 gram for dilution, 10 ml of novocaine is added.

If a child does not tolerate novocaine, then a solution of lidocaine or water is used.

In the intravenous method of administration of cefazoline, it is divorced by 5% glucose or 0.9% sodium chloride.

The method of breeding cefazoline is as follows:

1. From the bottle, the protective foil is moved.
2. A rubber lid is treated with a tonic alcohol tampon.
3. Novocaine is added to the cefassoline vial.
4. The resulting solution is strongly shaken for dissolution.
5. Take the syringe and fill it with the resulting solution.

Antibiotic Cefazolin Children: Contraindications and side reactions

It is forbidden to use cefazoline to breast children under one month, as well as kids, prone to intolerance of drugs related to the group of cephalosporins.

If the kidney function is violated, a particular medical control is required.

In case of sensitivity to penicillin group medicinal preparations There are manifestations of allergic reactions to the skin.

During the course of treatment, the presence of sugar in the urine, which disappears at the end after the ceffation of cefazoline.

The following manifestations are possible as adverse reactions:

It is not recommended to breed cefazolin novocaine for children under 18, as it worsens the work gastrointestinal tract, promotes a failure heart Rhythm And the appearance of pain in the child's area in the child. When appointing cefazoline together with Novocaine on the recommendation of the doctor, it is necessary to pre-make a trial to novocaine. In the absence of allergic reactions, it can be used for breeding under the strict control of the doctor.

It should be remembered that this drug is a strong antibiotic, therefore the feasibility of its application should evaluate the pediatrician.

Of all the antibiotics of the cephalosporin row of cefazolin is the least toxic, and therefore it is quite safe, as far as possible to apply to antibiotics. This antimicrobial means has a wide range of use, however, questions may arise with its immediate application, since the drug needs to be prepared. How to breed cefazoline for children and adults? How to put it correctly?

This semi-synthetic antibiotic has an impact on most unicellular microorganisms, gram-positive and gram-negative bacteria. The blood plasma is preserved for 12 hours, the greatest concentration reaches 1 hour after administration intramuscularly or intravenously. Used in case:

• Staphylococcus, syphilis, gonorrhea, sepsis
• Inflammation of the abdominal cavity
• Infectilation of biliary and urinary tract, musculoskeletal system, LOR organs, respiratory system
• Blood infection
• In order to prevent complications after surgery

Side effects are most often observed in people with individual intolerance of cephalosporins and penicillins, but the body's response with increased sensitivity is possible. nervous system (cramps), digestive, urinary and skin manifestations (itching, inflammation, swelling). For long use Dysbacteriosis develops.

• Due to the fact that the drug by the kidneys is excreted, with any pathologies of this body, the use of cefazoline should be coordinated with the attending physician, while the dosage always decreases, the drug is introduced once in order to prevent its accumulation in the kidneys.
• The drug cannot be used during pregnancy and lactation, as well as in children under the age of 1 year, in premature children. It is undesirable to use cefazolin for intestinal diseases.

Since the main form of release of this antibiotic is powder, it needs to be prepared. It is mainly used sterile water for injections, but sometimes it is bred by novocaine or lidocaine, thereby reducing the sensitivity of the administration area. With intramuscular administration, the pain of the zone of cefazolin is always noted.

• When administered cefazoline intravenously, through a dropper, 1 g of powder is dissolved in isotonic sodium chloride or glucose solution with a 5% concentration. Liquid volume - 250 ml. The duration of the procedure is 30 minutes, the adult is carried out twice. Maximum dosage - 6 g
• With the introduction of cefazolin intramuscularly, through the injection, 0.5-2 g of powder accounts for 3 ml of water for injection. Sodium chloride can also be used. For injection, intravenously increases to 10 ml.
• How to breed cefazolin novokain? For this purpose, 1% novocaine solution (or smaller concentration) is used, per 1 g of cefassoline accounts for 5 ml of novocaine.

The system of breeding powder liquid looks like this:

1. Foil is removed, the cover is processed by medical alcohol.
2. The liquid flows into the bottle with a powder.
3. The bottle shakes the granules to dissolve.
4. The resulting solution is introduced into the syringe.

The dosage of this antibiotic for children should prescribe a doctor, however, in a critical situation, you can calculate it yourself, and also put the baby yourself.

• On each kg of pure weight is taken from 25 to 50 mg of cefazolin, depending on the sensitivity of the body.
• Powder bottle for children must contain 0.5 g of antibiotics for maximum accurate dosage. With more high concentration (1 g, 2 g) 10 and 20 ml of liquid are taken, respectively.
• Water for injection or novocaine is also added to the vial, the syringe is canceled by the desired number of ml for administration.

The instructions and recommendations for the use of cefazoline do not replace the consultation of the specialist. When manifesting any side effects, the use of an antibiotic should be discontinued. Remember that the cefazoline solution can be administered only if it is completely transparent.

Cefasoline is an

antibiotic belonging to the first generation of the group

cephalosporins . Cephazoline is administered only injectable, since when taking inside (in the form of tablets), it is destroyed in the gastrointestinal tract, not so much to be absorbed into the blood and have an antibacterial effect. The antibiotic has a wide range of action, so it can be used to treat various

infections

Which are caused by microbes sensitive to it. Cephazoline is used to treat organically all systems, such as respiratory, urinary, sex, leather, joints, etc.

Forms of release and name

The antibiotic cefazoline is available only in the form of a dry powder intended for the preparation of a solution for intramuscular or intravenous administration. Powder is packed in glass bottles and hermetically evacted.

On the latin The name of the drug is written as follows - CEFAZOLIN, which is international name Antibiotic. Commercial names may differ from the international, since each pharmaceutical firm It can produce a drug with a cephazoline active substance, but give it a memorable and simple name. For example, the antibiotic cefazoline is produced under the following commercial names - Amzoline, Annef, Atralacef, Wolmizolin, Soline, Zolfin, Intratzolin, Iphizol, Cefzol, Lizolin, Nacef, etc. However, there are antibiotics whose name coincides with international Name Substances, such as cefazolin-acos, cefazolin-sandoz, etc. All listed drugs are the same - antibiotic cefazolin, which is applied standard, regardless of the name of the manufacturer. Only the quality of the drug produced by various pharmaceutical plants may differ.

Dosage To date, various pharmaceutical concerns produce cefazoline in the following dosage options:

• 250 mg;
• 500 mg;
• 1 g (1000 mg).

It is so much (250, 500 or 1000) milligram powder is in one bottle.
Therapeutic effects and spectrum of the action of cefazolin

Cephazolin refers to semi-synthetic antibiotics from a group of beta-lactam. These antibiotics kill pathogenic

bacteria

By destroying their cell wall. Cephazolin is able to destroy many types of microorganisms, therefore relates to the antibiotics of a wide range of action. Compared to other drugs from the first-generation cephalosporins group, it is the safest medicine, since it has minimal toxicity.

Basic and chief therapeutic effect Cephazolina is the destruction of pathogenic microorganism, which caused infectious inflammatory disease. Accordingly, the drug effectively cures infections and inflammation caused by microbes to which cefazolin acts destructive.

To date, cefazoline is effective in relation to the following pathogenic microorganisms:

• Golden Staphylococcus (Staphylococcus aureus);
• Epidermal Staphyloccus Epidermidis;
• Beta hemolytic streptococci from group A;
• Pyreptococcus Pyogenes (Streptococcus Pyogenes);
• Diplococcus pneumonia (diplococcus pneumoniae);
• Hemolytic Streptococcus (Streptococcus Hemolyticus);
• Viridal Streptococcus (Streptococcus Viridans);
• Intestinal wand (Escherichia coli);
• Klebsiella (Klebsiella SPP.);
• Protea (Proteus Mirabilis);
• Enterobacteria (Enterobacter Aerogenes);
• Hemophilic stick ( Haemophilus influenzae.);
• Salmonella (Salmonella SPP.);
• Shigella (Shigella Disenteriae, etc.);
• Neisseria Gonorrhoeae and Neisseria Meningitidis);
• Corinbacteria (Corynebacterium Diphtheriae);
• Pathogen of Siberian ulcers (Bacillus Anthracis);
• Clostridium pertringens;
• Spirochetics (spirchaetoceae);
• Treponema (Treponema SPP.);
• Leptospira (Leptospira SPP.).

This means that cefazoline is able to cure an infection of any organ caused by the above pathogenic microorganisms. Unfortunately, in view of the frequent and unreasonable use of antibiotics, their spectrum of action is steadily reduced, since sustainable types of microorganisms appear. Therefore, after 5 years, this list of bacteria to which cefazoline is destructive, can change significantly.

The antibiotic does not act on the cinema stick, mycobacterium tuberculosis, viruses, fungi and the simplest microorganisms (trichomonas, chlamydia, etc.).

Indications for use

Due to the fact that Cephazoline is destructive effect on many pathogenic microorganisms, it is used to treat infections of various organs. To date, the testimony for the use of cefazoline are the following infectious and inflammatory diseases:

• acute and chronic bronchitis;
• infected bronchiectases;
• pneumonia caused by bacteria (not fungi or viruses);
• bronchopneumonia;
• infections of the chest, developing after surgery (for example, after puncture, etc.);
• empiama pleura;
• abscess lung;
• otitis the middle ear;
• tonsillitis;
• mastoid;
• acute and chronic pyelonephritis;
• cystitis;
• urethritis;
• prostatitis;
• gonorrhea;
• skin infections;
• cellulite;
• mastitis;
• ryg;
• carbuncules;
• infected gangrene;
• infection on the wound or burn surface;
• skin infection or soft tissues after surgery;
• eye infection;
• osteomyelitis;
• septic arthritis;
• infections of biliary tract;
• an infection after an abortion;
• infection of the uterus;
• salpingitis;
• pelvic abscess;
• endocarditis;
• syphilis;
• sepsis;
• peritonitis.

The above pathologies are amenable to successful cure with cefassoline. However, the antibiotic can also be used to prevent the development of infection before and after surgery when removing the uterus, gallbladder, heart, bones and joint operations.
Zols Tsefazolin - instructions for use

Cephazoline is introduced intramuscularly or intravenously, pre-dissolving the necessary dose of powder in water, lidokain or novocaina. Dosage and frequency of cefazoline injections are determined by the severity of human condition and the potential danger of infection.

Crosses put in part of the body, where the muscular layer is well developed, for example, in the thigh, shoulder, buttock, etc. intravenously, cefazoline can be administered in the form of injections or dropper.

Powder should be brewed in the necessary person dosage. For example, if you need to enter 0, 5 g, the bottle is taken with the corresponding dosage of cephazoline powder. It is impossible to take a bottle with a dosage of 1 g and divide it in half to get a dose of 500 mg. But to obtain a dose of 1 g, you can take two bottles of 500 mg or four to 250 mg.

Intravenously injections of cefazoline in the dosage of less than 1 g are introduced in the form of slow injection. The solution is introduced into a vein for 3 to 5 minutes. If cefazoline is intravenously introduced in the dosage of more than 1 g, then the dropper should be used. An antibiotic solution in this case is entered at least 30 minutes.

The antibiotic solutions must be prepared immediately before use. High-quality solution should be transparent and do not contain any impurities, suspended particles, sediment or mut. A light yellowish shade of the finished solution is allowed, which is the norm and does not indicate the damage to the drug. If the resulting solution is not transparent, it is impossible to use it. It is also not allowed to use a solution prepared in advance. In exceptional cases, it is allowed to store the finished solution in the refrigerator no longer than 2 days.

The dosage of cefazoline is determined by the severity of pathology. Adults who do not suffer to renal failure should receive an antibiotic in the following dosages:1. Fine degree infections caused by Cockkops (staphylococci, streptococci) require the use of cefassoline at a dose of 500 mg - 1 g every 12 hours. You can enter 500 mg every 8 hours. The maximum daily dose is 1.5 - 2 g.

2. Acute uncomplicated urinary tract infections (

urertritcistics

etc.) - cefazoline administered 1 g every 12 hours. The daily dose of the antibiotic is 2 g.

3. Pneumonia

Caused

pneumococci

Requires the introduction of cefazolin at 500 mg every 12 hours. The daily dosage of the antibiotic is 1 g.

4. Heavy or moderate infections require the use of cefazolin at 500 mg - 1 g every 6 to 8 hours. Daily dose is 3 - 4 g.

5. Infections, threatening life, are treated with the introduction of 1 - 1.5 g of cefassoline every 6 hours. At the same time, a person receives 4 - 6 g of antibiotics.

It is possible to increase the dosage of cefazoline to 12 g per day when severe condition man when there is a question of life and death. Older people who do not have disorders of the kidney function are obtained by cefazoline in a conventional adult dosage.

People suffering from renal failure receive cefazolin in smaller doses. The specific dosage and the administration interval is determined by the value of the coefficient of creatinine filtering (QC) according to the rebarga sample. Daily, single doses and cefazolin administration interval for people with renal failure are reflected in the table:

If the kidney function in a person is unstable, it is necessary to constantly monitor creatinine clearance with the help of Rarba sample. In this case, the dose of cefazoline is determined every day, depending on the laboratory indicators.

Cefasoline injections are appointed at 7 to 14 days. It is not allowed to use an antibiotic less than 5 days, since the causative agent of infection can be destroyed not completely, and then sustainable types will be repaired, which is very difficult to treat. It is also not recommended to use cefazoline longer than 14 days, since in this case the sustainable subspecies of microorganisms can also be formed.

Cephazoline is applied not only with therapeutic goalBut for the prevention of infection with various surgical interventions. The preventive dosage of the drug is determined by the volume of operational intervention, and its duration. If the operation lasts less than 2 hours and its volume is small, then 1 g of cefassoline intramuscularly administered for the prevention of infection, 30 - 60 minutes before it starts. If the operation lasts more than 2 hours, then the cefazoline administration scheme is as follows: 1 g intramuscularly 30 minutes before the start, then 0.5 - 1 g intravenously every 2 hours during surgery.

After the operation to prevent infection, 0.5 - 1 g of cefasoline is administered every 6 - 8 hours, during the day. If the operation was extensive, complex and long, you can extend the course preventive application Antibiotic up to 3 - 5 days. At the same time, it is necessary to introduce cefazolin strictly every 6 to 8 hours, so that the blood concentration of the antibiotic is constantly maintained in the blood of a person.

If a person has an allergy to penicillin antibiotics or carbapenes, it is necessary to use cefazolin carefully. When developing signs of an allergic reaction, immediately stop using an antibiotic, or stop the introduction.

It is not recommended simultaneously with cefazolin to use antibiotics - aminoglycosides (for example, kanamycin, streptomycin, gentamicin, etc.), since in this case the risk of damage to the kidneys is significantly increasing.

How to breed antibiotic cefazoline - recipe

For intramuscular injection, cephazoline powder can be divorced in sterile water, lidocaine or novocaina. Since the injection of the antibiotic is very painful, it is preferable to breed a powder in lidocaine or novocaine, which are

anesthetic drugs

To prepare a solution for intramuscular injection into the vial with a powder, 2 - 3 ml of sterile water, 0.5% lidocaine or 2% of novocaine are introduced. After that, the bottle shakes intensively, up to the complete dissolution of the powder and the formation of a transparent fluid.

For intravenous injection, cephazoline powder is dissolved in sterile water. At the same time, not less than 10 ml of water, to ensure the introduction of the drug for 3 to 5 minutes. It is allowed to dissolve an antibiotic minimum in 4 ml of water, at the rate of 1 g of powder.

A solution for intravenous infusion (dropper) is prepared using 100-150 ml of the main solvent. The following drugs are applied as a solvent:

• sterile saline;
• 5% or 10% glucose solution;
• glucose solution in saline;
• glucose solution in Ringer's solution;
• 5% or 10% solution of fructose water for injection;
• ringer's solution;
• 5% sodium bicarbonate solution.

Most often, in domestic conditions, intramuscular injections of cefazoline are used. Therefore, we consider in detail how to properly breed the powder in solutions of anesthetics of lidocaine and novocaine.
Cephazoline with Novocaine and Cephazoline with Lidokain - how to breed?

For breeding cefazolin powder, 2% will be required

Novocaine

Lidocaine

Which are sold in pharmacies in sealed ampoules. You will also need sterile syringes. Methods of preparation of the cefazolin solution on Novocaine or Lidokain for intramuscular administration:

1. Gently inscribe and break the tip of the ampoule with a 2% novocaine solution or 0.5% lidocaine.

2. Open sterile syringe, put on the needle and lower it in an ampoule with novocaine or lidocaine.

3. You need to dial the amount of novocaine or lidocaine in the syringe (2 or 4 ml).

4. Remove the syringe from the ampoule with the novocaina or lidocaine.

5. Remove the metal cover from the bottle with the cefassoline powder.

6. Switch the needle syringe rubber bottle cover with cefazolin.

7. Gently squeeze all the contents of the syringe into the bottle with a powder.

8. Without removing the syringe, shake the bottle so that the powder is completely dissolved.

9. Screw the finished solution into the syringe.

10. Remove the syringe from the rubber plug, turn it up the needle.

11. Touch your finger on the surface of the syringe in the direction of the piston to the needle, so that air bubbles gathered at the base.

12. Press the syringe on the piston to release the air.

13. Make intramuscular injection.

The amount of lidocaine or novocaine is determined by the dosage of cefazolin. For breeding 500 mg of cefazoline, 2 ml of novocaine solution or lidocaine will be needed. And for dilution of 1 g cefassoline, 4 ml of novocaine or lidocaine is necessary.

Cefasoline Prix - Instructions for the use of children

Cephazolin U.

infants

it can only be applied if there is an acute need and threat of a child's life. In this case, the antibiotic is used only under the supervision of the doctor.

The dosage of cefazoline in children is determined by the weight pathology and body weight of the child. It is by mass that the daily dose of an antibiotic is calculated, which is divided into 2 to 4 administration. If the child suffers to renal failure, then the dosage also affects the glomerular filtration rate (QC), determined according to the rebar's sample.

Dosage cefazolin for children who do not suffer from kidney pathology, the following:

• With lung and medium-free infections, the daily dosage is calculated at the rate of 25-50 mg of an antibiotic per 1 kg of the child's mass. The resulting amount is divided into 2 - 4 administration per day.
• With severe infections, the dosage is calculated at the rate of 100 mg of cefazoline per 1 kg of the child's mass. The calculated daily dosage is divided into 3-4 administration.
• Newborn and premature body less than 2 kg are obtained by cefazoline in a one-time quantity of 20 mg per 1 kg, every 12 hours. That is, the daily dose of the antibiotic is 40 mg per 1 kg of body weight.
• Children over 7 days, and with a mass of more than 2 kg, the daily dose of the preparation is determined at the rate of 60 mg per 1 kg of weight.

Newborn and children under 1 month, the rate of removal of cefazoline is low, therefore it is not recommended to exceed the recommended dosage.

If the child suffers to renal failure, the cefazolin dosage definition algorithm is the following:1. Calculate the dose by body weight, as for a child who does not suffer from kidney pathology.

2. Conduct the rebar test and evaluate Creatinine clearance.

3. Calculate the dose of Cefazolin, which can be introduced to the child, according to the relations reflected in the table:

However, the first dose of Cefazolin to children suffering from renal failure is completely injected. And then all subsequent decrease to the required quantity depending on the clearance of creatinine.
Cephazolin injections to children - how to breed?

Cefazoline injections should be breed solely on novocaine or lidocaine solutions. Moreover, it is better to choose that anesthetic that has the best painkillers from this particular child. In most cases, lidocaine has a more pronounced analgesic effect, therefore it is recommended to use this drug to prepare a cefazolin solution for injections. If there is an opportunity, you can make a child one injection of cefazoline with novocaine, and one - with lidocaine, so that the baby himself rated, which solution has a better painkillers.

Cephazolin powder for intramuscular injuries to children are bred immediately before use. The dose of an antibiotic less than 500 mg is diluted in 2 ml of novocaine or lidocaine. A dose of more than 500 mg requires 4 ml of lidocaine or novocaine. The sequence of cephazoline breeding actions is as follows:

1. Open the ampoule with lidocaine or novocaine, omit the tip of the syringe needle into the solution.

2. Dial the required amount of solution - 2 or 4 ml of novocaine or lidocaine.

3. Purify the needle the bottle cover with Cephazolin powder.

4. Pull novocaine or lidocaine into the vial and without removing the needles, vigorously mix the contents to obtain a solution.

5. Gently draw all the contents of the bottle into the syringe.

6. Remove the syringe from the bottle and make an intramuscle.

Application during pregnancy

Cephazoline penetrates the placenta and has an impact on the fetus, therefore the antibiotic

pregnancy

it can only be used if there is absolute indications when the threat arises for the life of the mother. To date, it is definitely not clear what kind of cefazoline on the fetus is affected, so when deciding on the use of antibiotic is pregnant, it is necessary to carefully weigh the ratio of the possible risk / intended benefit.

To date, the tests of cefazoline were carried out only on pregnant rats. Moreover, the drug in large doses did not cause teratogenic action, that is, did not lead to the formation of congenital reasons of the fetus. However, such controlled studies on pregnant women for obvious reasons were not conducted.

Cephazoline also penetrates into breast milk, although it is detected in small concentrations. However, if it is necessary to use it during breastfeeding period, a child should be transferred to artificial blends during treatment.

How to prick antibiotic cefazoline?

The intramusculin should be administered to the cefazoline only in those parts of the body, where the person is well developed a muscular layer. It is usually anterior and side surface of the thigh, buttocks, shoulders or abdominal press. Since the injection is very painful, and at the place of introduction it is often a seal is formed, it is recommended to change the fields of the loop in turn. For example, one injection is placed in the buttock, the second is in the thigh, the third one is in the shoulder, the fourth - in the abdominal press. Then begin again from the buttocks, and so alternate the place of administration of cefazoline until the very end of the course of treatment.

Intramuscular injection should be done slowly - at least 3 - 5 minutes, gradually introducing a medicine. The needle should be introduced deep into the muscle so that the medicine does not fall into subcutaneous fatty tissue. After the introduction of cefazoline, the injection site should not be warm, as this may lead to the development of aseptic inflammation. When conducting cefazoline injections should be observed general requirements to the performance of data from medical manipulations:

1. Processing the place of injection by antiseptic (70% alcohol, etc.).

2. Use only a sterile syringe with a sterile needle.

3. Release air from a syringe with a finished solution.

4. Place the needle vertically to the skin surface and introduce it deep into the muscle.

5. Slowly put pressure on the piston, introducing a medicine for 3 to 5 minutes.

6. By entering the whole solution, take out the needle, holding it over the edge, put on the syringe.

7. Handle

antiseptic

Many people are used for intramuscular cephazolin injections (especially children) needles for intravenous injections, seeking to reduce pain. However, this cannot be done, because a thin needle for intravenous injections often slipping and goes into the crowd of muscles, while remaining there for many years and delivering a person an inconvenience. Surgeons often face similar phenomena when they have to get the needles from the syringes from the buttocks and the hips, which broke down and went to the "muscle" a few years ago. In addition, the use of a thinner needle does not reduce the pain of the administration of cefazolin.

How much to prick cefazoline?

The duration of the use of cefazoline depends on the severity of infection and the rate of recovery. The course of treatment lasts from 7 to 14 days. It is impossible to use cefasoline injections less than 5 or more than 15 days, since in this case there is a high risk of developing microorganisms resistant to antibiotic. These stable microorganisms are able to again cause an infection that will have to be treated again, only with the use of another, even stronger antibiotic. Unfortunately, a great risk is that the microorganism may be stable to another antibiotic. In this case, the forecast for life is unfavorable, since there are very few antibiotics in the world that can cope with sustainable microbes. And if they do not help, then you can only count on

immunity

sick.

That is why the use of antibiotics, including cefazolin, must be referred to. It is impossible to throw injections as soon as a person becomes better, considering the treatment ended. At least 5 days of cefazolin injuries must be done, overcoming pain and reluctance. This is especially true for children. After all, the child is faster and easier than an adult, can "purchase" sustainable types of microbes that will constantly cause infections, difficult to treat.

Side effects

For the most part, the side effects of cefazolin concern the organs of the gastrointestinal tract, or are limited to increased sensitivity. If a person suffers from hypersensitivity in relation to any other

medications

The risk of development is also high to the cefazoline. In addition, there relatively often develops increased sensitivity to antibiotic in people who have a tendency to allergic reactions,

bronchial asthmepolynoz.u.

Consider the specific symptoms of the side effects of cefazolin on the part of various organ systems.

Gastrointestinal tract. Most often, side effects are observed in the form of loss of appetite, glossite, heartburn, pain in the abdomen, nausea, vomiting and diarrhea. It is less likely to develop candidiasis or pseudomambranous colitis. According to laboratory tests, an increase in the activity of alkaline phosphatase, AST and Alt (drug hepatitis) is possible, as well as an increase in the concentration of bilirubin in the blood (stagnant jaundice).

Allergic reactions. The antibiotic can cause the development of hypersensitivity reactions, which are manifested by drug fever, skin rash (urticaria), itching, spasp of respiratory tract and increasing the number of eosinophils in the blood. In rare cases, the development of swelling (angioedema edema), pain in the joints, allergic jade, anaphylactic shock or multiform exudative erythema is possible.

Blood system. Rarely rarely cefazoline is capable of decreasing the number of neutrophils, platelet and leukocytes in the blood. This reduction in blood cells is reversible, their normal amount is restored after the discharge of the drug. A single cases of blood clotting disorders and the formation of hemolytic anemia have been revealed.

Urinary system. It is possible to increase the concentration of urea and creatinine in the blood according to laboratory tests. When using large doses of the antibiotic, a violation of the functional activity of the kidneys is possible. In this case, the dosage of cefazoline is reduced, and further treatment is carried out under constant control of the concentration of urea and creatinine in the blood.

Local reactions. The main local response is strong pain in the introduction of an antibiotic. In some cases, a seal may form at the injection site. In rare cases, intravenous administration of the antibiotic can provoke the development of a phlebitis.

Other organs and systems. Cephazoline can lead to the development of such side effects as dizziness, squeezing feeling in chest, cramps, dysbacteriosis, accession of another infection, candidiasis (candidoid stomatitis or vaginitis). When developing candidiasis or accession of another infection, it is necessary to resolve the further feasibility of the use of cefazoline.

Contraindications

In the presence of allergies to any other antibiotics from the cefalosporins group, cefazoline is categorically prohibited. If a person has allergies to penicillin antibiotics, then Cephazoline is introduced carefully, having prepared a set to combat anaphylactic shock, since there are cross allergy between the data of two groups of drugs.

Also an antibiotic is contraindicated to use during pregnancy and breastfeeding. Babies up to 1 month cefazoline are not introduced, since there are no scientifically confirmed data on its safety for newborns.

Today, the antibiotic cefazoline is produced under different names, but all these drugs are synonymous, since they contain the same active ingredient. All synonyms of cefazolin are powder designed to prepare a solution for intramuscular or intravenous administration. On the domestic pharmaceutical market there are the following synonyms of Cefazolin:

• Amzoline;
• An'ncef;
• Atralacef;
• Wulmizolin;
• Solin;
• Zafin;
• Intrasoline;
• Iphizol;
• Cefzol;
• Lysoline;
• Natsef;
• Orizoline;
• Orpin;
• Transoline;
• Reflin;
• Totacef;
• Cesiline;
• Cephazolin-Biochemi;
• Cephazolin-Watham;
• Cephazolin-KMP;
• Cephazolin Nikomed;
• Cephazolin Sandoz;
• Cefazolin-teva;
• Cephazolin Elf;
• Cephazolin-AKOS;
• Cephazolin-Fereyn;
• Cefazolina sodium;
• Cefhamesein;
• Cefaprim;
• Cefezol;
• Cefzolin;
• Cefow.

Only antibiotics from the first-generation group of cephalosporins, which are intended for use inside or injectable, can be attributed to the analogues of the cefazolin. That is, analogues are antibiotics that have the same spectrum of action, as well as cefazoline, and belong to the same group and the same generation. The counterparts of cefazoline include the following drugs:

• Granules, capsules, powder and tablets cephalexin;
• Cephalotin powder;
• Capsules Ecocoufron.

Reviews

Cephazolin is powerful and effective antibioticTherefore, the reviews about it are predominantly positive. Often, this drug is used to treat an angino when amoxicillin turned out to be ineffective. Especially often positive feedback on Cefazoline leave parents who managed to cure children from any serious infection after a long period of use of other antibiotics that were ineffective. Also positively respond about the preparation of adults, which used the drug for therapy acute infections urinary tract.

The negative quality of Cefazolin, according to most people, is soreness of injections. However, against the background of the high efficiency of the antibiotic, people perceive this factor as a lack, which, however, can be survived and endured.

Negative cephazoline reviews are extremely rare. Leave their people to whom the drug did not help cure the disease or caused a strong allergic reaction in the form of itching. Unfortunately, there are types of microorganisms resistant to cefazolin, and the allergies are one of the side effects of the drug, so it is not suitable for all people.

The cost of cefazoline may be different, depending on the manufacturer's company. The estimated prices of cefazoline of various dosages and manufacturers are presented in the table:

When buying cefazoline should pay attention to the integrity of the packaging. If the vials are packaging with damage, it is not necessary to purchase the drug, since it may turn out to be poor quality.
Cephazolin for cats

Cephazoline is successfully used by veterinarians for the treatment of severe infectious diseases in cats. The antibiotic helps to cope with blood infection,

meningitimeritonitis

Infections of genital, urinary and respiratory organs, as well as bones, joints and skin. In addition, Cefazoline heals infections of wound and burn surfaces.

Cats can develop allergies to the drug. Also K. by-effects Cats include diarrhea, vomiting, dizziness and itching. At the place of administration of cefazoline can be formed a small seal.

Cephazoline cats are introduced into the back of the thigh on the back leg. The drug is bred in lidokain or novocaine. The course of therapy is from 5 to 10 days. The dosage is calculated by the weight of the animal, at the rate of 10 mg per 1 kg of mass.

ATTENTION! The information posted on our website is a reference or popular and provided with a wide range of readers for discussion. The purpose of medicines should be carried out only by a qualified specialist, on the basis of the history of the disease and the results of diagnosis.

Medicinal Cephazolin is a semi-synthetic antibiotic tool I have a generation wide spectrum Antimicrobial influence. The drug is used for therapy of infectious lesions of the skin, soft tissues, a bone-topic apparatus, endocarditis, pneumonia, peritonitis, abscess of light, inflammatory processes of infectious nature in urinary tracts, as well as a means of preventing complication after surgical operations. Cefasoline is contraindicated to children up to 1 month, pregnant patients, people with hypersensitivity and nursing mothers.

Dosage form

Cephazoline is produced in the form of a powder intended for the preparation of an injection solution. It can be packaged into transparent glass bottles of 0.5 g, 1 g or 2 g. In each cardboard pack is 1, 5, 10 or 50 bottles of the drug.

Description and composition

The cefazoline preparation is a hygroscopic white powder with a yellowish tinge. 1 bottle contains 1 g sodium salt Cefazolina.

Pharmacological group

Cefasoline is an antimicrobial agent of a semi-synthetic form I generation, which has an extensive spectrum of antibacterial influence. The tool has a pronounced bactericidal effect on a series of gram-positive (staphylococci, streptococci, diphtheria Corinbacterium) and gram-negative (protea, Salmonella, Schigella, Chlebseyella Pneumonia, intestinal wand, enterobacter, hemophilic wand, gonococcus) microorganisms. To the influence of cefazoline resistant viruses, simplest, rickettsia, indole-positive strains of protein bacteria and mushrooms. The drug oppresses the synthesis and development of the cell wall of the microorganism. By pharmacological action Cephazolin compare with penicillins.

After intramuscular administration, cefazoline is quickly absorbed. The maximum concentration in the blood plasma is observed 60 minutes after administration and can be maintained at an effective level for 8-12 hours. The removal is carried out mainly by the kidneys (up to 90%). Displays unchanged.

In the case of intravenous administration, the concentration of the blood serum is significantly higher than with intramuscular administration. However, the removal of medication from the body is faster. The half-life can be about 120 minutes.

Cephazoline penetrates through a placental barrier. May be observed in breast milk In extremely minor concentrations.

It has a high degree of penetration in the body of the joints through a synovial shell, subject to inflammatory process.

Indications for use

The preparation of cefazoline is used to treat pathologies caused by microorganisms sensitive to the action.

for adults

The main indications for the use of cefazoline tools are the following states:

• infectious damage to urinary tract (including acute form pyelonephritis);
• endocarditis;
• infections of connective and bone tissues (including osteomyelitis);
• septicemia;
• syphilis;
• infectious lesions of the lower and upper respiratory tract;
• mastitis;
• infections of skin and soft tissues (including burn and wound infectious damage);
• gonorrhea;
• bacterial infections of biliary tract and abdominal organs.

Also, the medication is used to prevent the development of infectious infection in operational interventions.

for kids

For children under 1 month, it is forbidden to accept the means of Cefazoline. Children aged from 1 month, the use of the drug is prescribed by the same indications as the patients of the adult category.

Patients who carry a child are contraindicated receiving funds. The use of cefazoline can be undertaken exclusively in cases where the expected benefit for a woman significantly exceeds the possible negative effects for the development of the fetus. Nursing mothers for the use of the medication should be abandoned by GW. Otherwise, the use of cefazolin is prohibited.

Contraindications

Cefasoline contraindicated:

• nursing mothers;
• kids up to 1 month;
• patients with individual intolerance and hypersensitivity to cefassoline or other antibiotic drugs of the cephalosporin group;
• pregnant women.

Caution should be taken to the agent to patients, with renal failure.

Applications and doses

Cooked injection solution Cephazolina must be administered exclusively intravenously or intramuscularly. Drop or inkjet administration is allowed.

For the preparation of intramuscular injections, it is necessary to dissolve the contents of the vial in 5 ml of saline or water for injection. Imagine the solution should be deep inside the muscle tissue.

For the preparation of intravenous injection injection injection injection, the necessary dosage of the medication in 8-10 ml of physiological solution should be selected. Introduction should be carried out within 4-5 minutes.

The drip administration solution is created by mixing the contents of the vial (0.5-1 g) in 150-250 ml of physiological solution or a 5% glucose solution. Drip administration should be carried out within 30 minutes at a speed of 65 to 80 drops per minute.

for adults

The daily rate of the drug cefazoline directly depends on the nature of the pathology and sensitivity of pathogenic microflora to the action of an antibiotic. On average, the daily dose can be from 1000 mg to 4000 mg.

In the treatment of pathologies caused by gram-positive microorganisms, it is necessary to take the drug in a dosage of 250 mg to 500 mg every 8 hours.

For therapy of infectious diseases caused by gram-negative bacteria, 500-1000 mg of cefazolin is assigned every 8 hours.

For pneumococcal infections Respiratory organs, as well as urinary tract diseases, should be taken from 500 mg to 1000 mg of medication every 12 hours.

For the treatment of severe forms of pathologies (for example, endocarditis, urological diseases, acute hematogenous osteomyelitis, peritonitis, sepsis, destructive pneumonia), it is necessary to take a one-time dosage of the drug in the amount of 600 mg at an interval of 6-8 hours.

In case of violations, the kidney work should increase the interval between the receptions and reduce the dosage of the drug. With significant kidney pathologies, the daily rate should be 10% of the usual dosage. In this case, the interval between injections should be at least 24 hours.

for kids

Children under the age of 1 month are assigned to the reception of cefazolin in the amount of 20-50 mg of the drug for each kg of the child's weight. With severe pathologies, it is allowed to take 100 mg / kg.

With minor disorders of kidney function in children, the average daily dosage should be 60% of the standard norm. With severe disorders of the kidneys, the reception of cefazoline is contraindicated.

Children up to 1 month are prohibited from taking an antibiotic.

for pregnant women and during lactation

Pregnant patients and nursing mothers are forbidden to take cefazoline. With the most needed, the doctor can allow the reception of the means of pregnant. In this case, constant monitoring of the condition of the patient and the fetus is necessary. For reception during lactation, you should stop feeding with maternal milk.

Side effects

The most common side effects Against the background of using cefazolin are:

• dysbacteriosis;
• dizziness;
• diarrhea;
• drowsiness (less often insomnia);
• bronchospasm;
• pain in the abdomen;
• an increase in the concentration of creatinine and nitrogen of urea in blood serum;
• rash on the skin;
• swelling quinque;
• loss of appetite;
• jaundice;
• leukocytosis;
• feeling of heat;
• anxiety and irritability;
• agranulocytosis;
• nightmares;
• rhinitis;
• breast pain;
• stevens-Johnson syndrome;
• weakness;
• cough;
• confusion of consciousness;
• nausea and vomiting;
• hives;
• transient hepatitis;
• pseudomambranous enterocolitis;
• hyperthermia;
• layella syndrome;
• violation of colorability;
• leukopenia;
• renal failure;
• thrombocytopenia;
• candidiasis;
• vaginitis;
• flebitis in the field of intravenous injections;
• hemolytic anemia;
• hypoglycemia (less often hyperglycemia);
• pain in the field of intramuscular administration.

Interaction with other medicines

Due to the existing antagonism between cefazolin and bacteriostatic antibiotics (for example, erythromycin, tetracycles, chloramphenicol, sulfanimides), the simultaneous use of these drugs is not recommended.

Permanent control of blood coagulation parameters should be conducted by combining cefazoline with high heparin dosages or oral anticoagulants.

The probelexide contributes to a decrease in renal clearance of the drug Cefazolin.

There is a mutual decrease in pharmacological activity while simultaneously use of cefazoline with aminoglycosides.

Also, combination with aminocosides and diuretic medicines can provoke the development of toxic reactions.

special instructions

When combining cefazoline with lidocaine, positive results may be observed at the reception of doping athletes.

If the patient has a serious degree of diarrhea, an option for the development of pseudommabranous colitis is not excluded. It is forbidden to take medicines affecting the peristaltic.

Also, cefazoline can give a false positive result of the tests for the content of glucose in the urine when using the Feling solution, Benedict or the clinitesty preparation.

The tool may cause confusion of consciousness, dizziness or drowsiness. In the period of therapy, it should be extremely careful when managing vehicles or work with potentially dangerous mechanisms.

Overdose

Symptoms of overdose:

• thrombocytopenia and thrombocytosis;
• convulsions;
• pain syndrome;
• leukopenia;
• paresthesia;
• dizziness;
• eosinophilia;
• an increase in the prothrombin index;
• improving the level of liver enzymes, creatinine; Bilirubin and urea nitrogen in the blood.

• cessation of medication;
• conducting symptomatic treatment;
• control of the functioning of the body and carrying out laboratory tests;
• conducting hemodialysis (especially severe cases).

Storage conditions

The remedy is released from the pharmacy according to the recipe.

Store cefazolin follows in a direct light and access children room temperature (up to 25˚C).

Shelf life - 3 years.

Prepared solutions must be stored at a temperature of 2-8˚C no more than 24 hours.

The drug Cefazolin has several popular analogues on the drug medicine market.

Cefhamesin

The direct analogue of the means is a powder for the preparation of a / m and in / in injections Cefhamesein. The drug has similar properties and can be proposed as a direct substitute for cefazoline during the therapeutic process.

Produced in the form of powder for the preparation of oral suspension. The current component is cephalexin. It is a semi-synthetic antibiotic agent of a group of cephalosporins with a wide range of influence. The most priority is the use for the treatment of infectious pathologies of the ENT organs and the respiratory system, osteomyelitis, infections of the genitourinary system, skin and soft tissues.

Cefadroxyl

It is a cephalosporin antibiotic for systemic use. Used for the treatment of infections of the urinary system, respiratory tract, skin and soft tissues and osteomyelitis. It can also be used to treat septic arthritis. Produced in the form of powder for the preparation of oral suspension. Active Component - Cefadroxyl.

The cost of cefazoline averages 290 rubles. Prices fluctuate from 17 to 1002 rubles.

Antibacterial drug Cephazolin is a semi-synthetic antibiotic, which is intended for parenteral administration (that is, in a vein or in the muscle). Cefazolina in tablets, as well as instructions for their use, does not exist, as it is completely destroyed in the digestive tract.

The medicine is a breeding powder in glass bottles. Often used in hospitals in order to prevent infections in the early postoperative period. Ambulatory is appointed usually in the case of inflammation of the respiratory tract, the skin and the organs of the urinary sphere.

Cefasoline Prix - Instructions for use

The drug is a powerful antibiotic, which is permissible to use only on the recommendation of the attending physician. Before starting treatment, it is desirable to determine the specific variation of the pathogen with the help of Bakposev, since the cefalosporins of 1 generation, despite the wide range of antimicrobial activity, do not act on some common strains. In addition, the dosage requires individual calculations to make a doctor. Treatment time also establishes a specialist.

The composition of the drug

The active ingredient is cefazoline, a semi-synthetic compound from the first generation of beta-lactam antibiotics-cephalosporins. According to the mechanism of bactericidal exposure, it is similar to penicillins: destroys the cell wall by inhibiting peptidoglycan and prevent biosynthesis. The antimicrobial spectrum of the action cefazoline includes the following pathogens:

• Gram-positive pneumatic and staphylococci (including strains forming penitzzinase), Bacillus Anthracis, diphtheria stick ..
• Gram-negative pathogenic neisseria meningitidis and gonorrhoeae, haemophilus influenzae, intestinal wand, enterobacter aegenes. The clinical significance of antibiotic therapy Shigell and Salmonella last studies are questioned.
• Some spiral bacteria (leptospiraceae and spirocaetaceae).

Antibiotic resistance exhibit some anaerobes, pseudomonads, protea, tuberculosis wand. In general, for the cephalosporins of the first generation, antimicrobial activity is characterized in relation to mainly gram-positive microorganisms.

Cephazolin and Ceftriaxone: What is their difference?

Sometimes patients have such a question after appointing the drug. Both of them belong to the parenteral antibiotics-cephalosporins, but Ceftriaxone has already belongs to the third generation and has obvious advantages over the predecessor. First, the spectrum of action is significantly wider, which increases the list of indications for use. Secondly, this antibiotic is excreted out of the body longer than cefazoline, respectively, and injections can be done less often (enough 1 time per day with medium-sized pathology forms).

Release form Cefazolina

By writing the drug, the doctor draws up a recipe for cefazoline on Latin as follows:
RP.: CEFAZOLINI PRO INJECT 1.0

S.: Before use the contents of dilute in 4 ml of water for injections, enter 2 ml of the resulting solution every 12 hours.

In Latin, the pharmacist reports the name and form of the drug, dosage and number of bottles. That is, need cefazoline for injection, 10 bottles of 1 gram active substance. The Russian instructions are given in Russian. More details of the breeding rules are considered in the relevant section.

Release form Cefazolina

White powder (sometimes slightly yellowish) color is an antibiotic in the form of a water-soluble sodium salt. Produced by pharmaceutical enterprises different countries. In pharmacies you can meet the drug of Russian, Belarusian, Indian, Swiss production under various trade names.

Photo Cefazolin

The original remedy is sold in glass bottles with a rubber plug, an enhanced metal cap. Vials (one or several pieces) are packed in a cardboard box. There are several dosage options for antibiotics: 0.25, 0.5 or 1 gram. Before the / m and in / in the introduction of the powder is divorced by anesthetic, water for injection or saline in accordance with the appointment.

Pharmacies also encounter gel drops in nose with cefazolin. Designed for the treatment of bacterial rhinitis, including children. Produced in small (10 ml) plastic bottles with a dropper nozzle. In addition to 0.5 g of antibiotics, water, aminocaproic acid, suprastine, xylomezoline and starch-agar gel are included. In addition to bactericidal, a vasoconstrictor and antihistamine action is rendered.

Cephazolin - Indications for use

In accordance with the spectrum of antimicrobial activity, the drug is assigned to inflammatory processes Different organs and systems. The main indications for the purpose of injection of this ABP are:

• severe localized or generalized infections (peritonitis, endocarditis and sepsis);
• caused by susceptible microorganisms of inflammation of the respiratory tract and putty sinuses nose (especially effective cefazoline during hymorite);
• bacterial damage to bones, muscles and skin;
• inflammatory processes in small pelvis organs, including STIs such as gonorrhea and syphilis.

The special importance of cefazoline has in the perioperative prevention of infections. For this purpose, intravenous injections are often prescribed in hospitals before surgery and after it.

Contraindications

Cephalosporins belong to one of the most harmless antibiotics and have very few restrictions on use. The main month of the life of the child and the individual intolerance of beta-lactam are antibacterial drugs. Since the active ingredient enters the milk, the appointed cefazoline during breastfeeding requires temporary termination of the latter. Milk should be contacted in order to preserve lactation. Careful approach to the appointment requires colitis and renal failure in the history of the patient.

Cephazoline during pregnancy

After parenteral administration, the antibiotic quickly penetrates almost all the fabrics and organs, overcoming, including the placental barrier. However, convincing research on the effect of the drug on the growing fruit was not conducted, but clinical practice did not reveal the teratogenic effect. Therefore, today Cephazoline during pregnancy is applied on any of its period, without restrictions. However, it is recommended to simulate the need for antibiotic therapy and its possible negative consequences.

Dosage cefazoline for adults

The drug is quite quickly excreted from the body, so it is required to make 2-3 injections per day to maintain its blood concentration. It is introduced both intramuscularly and intravenously, and the course of treatment is 1 or 2 weeks.

• Infection middle severity It is usually treated intramuscular injectionswhich are set with 8-12-hour intervals. The one-time dose is determined by the doctor in the range of 0.25-1 grams of the antibiotic.
• Heavy inflammations require an increase in dosage up to 4-6 g per day, and the minimum motherwise dose Must be from 0.5 to 1 gram.
• Prevention of postoperative purulent complications is carried out in several stages. An hour before, 1 g of the drug is introduced, sometimes in the same dose once in the process and for the next day three or four times at 500-1000 mg.
• Persons with deficiency of the kidneys are prescribed reduced doses (in accordance with the Creatine Clementine Clementines), but the initial must always be maximum.

Before administration, the powder is divorced according to the instructions for the use of cephazoline injections, where it is indicated how to breed novocaine: water for injection or saline. Under the hospital conditions for intravenous injections through a dropper, saline, solution of dextrose, sodium bicarbonate, or ringer in an amount of 50-100 ml. Ambulatory treatment is usually intramuscular injections for which there are separate methods.

Water breeding for injection

Annotation to the drug, for example, the Cefazoline AKOS instruction recommends using injecting water. Its quantity depends on the dosage of the antibiotic in the vial: for every 0.5 g of the powder there should be 2 mg of fluid - a one-time dose. However, if it is 1 gram of a valid substance, then a 2.5 ml of solvent can be taken. But, since injections are rather painful, doctors often advise the use of anesthetics for breeding.

How to breed cefazoline lidocaine or novocaine

Previously, the antibiotic was dissolved in novocaina (0.25 or 0.5% r-p), from the calculation of 5 ml per 1 gram of powder. However, today it is recommended to apply another anesthetic - lidocaine for this purpose, which is more suitable as a solvent for parenteral antibacterial agents.

To carry out the manipulation, the bottle will need a bottle in a prescribed dosage doctor, ampoule 10 ml of lidocaine solution (1%) and a pair of disposable syringes. The sequence of actions looks like this:

• Open the ampoule with anesthetic and remove the central part of the metal cover from the bottle with the powder.
• Screw to a sterile syringe of 3.5 ml of r-ra lidocaine, enter the needle into a bottle with an antibiotic (directly into the rubber stopper) and pour anesthetic.
• Without taking out the needles, vigorously shake the mixture so that it becomes homogeneous.
• Imagine fluid back into the syringe, disconnect it from the needle and put on it to other, sterile to perform an injection. Air bubbles at the same time should not be inside.

If dilution by 2 injections is made (for example, in the vial of 1000 mg of the active substance, and the one-time dose is 500), 5 ml of lidocaine is taken, 2.5 ml of the resulting solution is used for injection, and the rest is stored in the refrigerator until next time.

How to make pricks tofazolin children?

Age limitations for the drug - the first month of the life of the child, especially for premature babies. This is due to possible renal dysfunction, but there is no reliable data on the influence of newborns. Starting from a two-month age, the antibiotic is assigned from the calculation of 25-50 mg per kilogram of body weight per day (in the case of a heavy infection - up to 100). This amount is divided into equal parts and is introduced with a six-hour or eight-hour interval.

Side effects Cefazolin

Due to the low toxicity of cephalosporins, the negative reactions of the organism on the drug are rarely noted. There may be such phenomena as:

• allergies (from rash and itching to anaphylactic shock);
• dyspeptic disorders, intestinal candidiasis, liver dysfunction;
• bleeding disorders, hemolytic anemia;
• failures in the work of the kidneys, itching outdoor genital organs.

Since the medicine is applied parenterally, sometimes developing a flashlight at the site of intravenous administration or an intramuscular pain occurs.

Cephazolin and alcohol

Most often, the harmful effects of such a combination, as antibiotic therapy and alcohol, are associated with increased liver load. Most antibiotics and ethanol are metabolized in this body, whose cells are not cope with the double work and massively dying.

However, the preparation considered in becoming is derived from the kidneys, by practically no effect on hepatocytes. Does this mean that cefazolin and alcohol can be combined? No, it is impossible to do this, since both of them fall into the bloodstream and cause intoxication. There are vomiting, heat, headache, Tachycardia and other symptoms of disulfram-like reaction, up to seizures. At the end of treatment, it is also necessary to withstand a pause of at least 3 days.

Cephazoline - Analogs

The list shows preparations containing cefazolin and which are its analogues on the active substance:

• Orizolin
• Amzolin.
• Reflin
• Cephazolin Sandoz
• Cephazolin Elf
• Nacef
• Atralacef
• Wulmizolin
• Zolin
• Zavfin
• Intrazolin
• Cephazoline "Biokhemi"
• Iphizole
• Cefazolina sodium salt
• Cephazolin-Teva
• Cefzol
• Lizolin
• Cefezol
• Cephaprim
• Cefzolin
• Cephazolin-KMP
• Cephazolin Nicomed
• Annef.
• Sefazol.
• Totacef
• Cesiline
• Cephazolin Watham.
• Cefhamesin
• Cefow
• Cephazolin-AKOS
• SPOROLIN.

Zols Tsefazolin Children - Reviews

Since the toxicity of the drug is low and it can be prescribed from the second month of the child's life, it is one of the most commonly used in pediatrics. Doctors characterize an antibiotic as very effective tool In the fight S. dangerous infectionsWhat is confirmed by the reviews of the parents. Adverse reactions Little patients are extremely rare, and the disease quickly retreats.

The only minus of medications, like all parenteral forms of medical preparations, is painful introduction. Children of injections do not like, so sometimes the use becomes problematic. However, if you breed anesthetic powder, then pronounced pain can be avoided. Sometimes parents have difficulty calculating the dose, which are also easily solved attentive reading instructions and consulting the pediatrician.

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Clinical and Pharmacological Group

Cephalosporin I generation

Release form, composition and packaging

White or almost white.

Powder for preparing a solution for in / in and in / m administration

Glass bottle (1) - cardboard boxes.

Powder for preparing a solution for in / in and in / m administration From white to almost white.

Glass bottle (1) - cardboard boxes.

pharmachologic effect

Cephalosporin antibiotic I generation. Acts bactericidal.

It has a wide spectrum of antimicrobial action. Active as with respect to gram-positives (Staphylococcus SPP., Non-producing and producing penicillinase, Streptococcus SPP., Pneumocccccus SPP., C. Diphtheriae, B. Antracis) and gram-negative microorganisms (N. Meningitidis, N. Gonorrhoeae, Shigella SPP., Salmonella SPP., E. coli, Klebsiella SPP.). Actively is also active with the SpirocaetaEae and Leptospiraceae.

The drug is not effective in relation to P. Aeruginosa, Indo-positive strains Proteus SPP., M. tuberculosis, anaerobic microorganisms.

Pharmacokinetics

When taking inside collapses. T Cmax after the introduction of 0.25, 0.5 and 1 g - 1-2 hours, the value of Cmax - 17, 38 and 64 μg / ml, respectively. After the introduction of 1 g of Cmax by the end of the infusion of 188 μg / ml, after 8 h - 4 μg / ml.

Communication with plasma proteins is 85%. Vd - 0.12 l / kg. Penetrates the organs and tissues of the body (including joints, sss, abdominal cavity, kidneys and urinary paths, middle ear, placenta, airways, skin I. soft fabrics). In patients with a normal function of biliary tract, the concentration in the tissue of the gallbladder and the bile is significantly higher than in the plasma. In case of obstruction of the biliary tract, the concentration in bile is significantly less than in the plasma.

Metabolized in the liver. T1 / 2. — 1.4-1.8 h (in newborns under the age of 1 week - 4.5-5 h). Examined by the kidneys of the exempted form during the first 6h - 60-90%, after 24 hours - 70-95%. If the kidney function is violated T1 / 2 - 3-42 hours. Moderately excreted during hemodialysis.

Indications

Infectious-inflammatory diseases caused by the sensitive drug by the pathogens:

Peritonitis;

Endocarditis;

Respiratory tract infection;

Infections of the urinary tract, incl., Syphilis and gonorrhea;

Infectious damage to bones and joints.

Prevention of postoperative complications.

Contraindications

Pregnancy;

Lactation;

Increased sensitivity to drugs of a group of cephalosporins and other beta-lactam antibiotics.

Do not prescribe newborns.

FROM caution - Renal / hepatic insufficiency, pseudomambranous enterocolitis.

Dosage

In / m, in / in (stove and drip). Average daily dose for adults - 0.25-1 g; The multiplicity of administration is 3-4 times / day. Maximum daily dose - 6 g (in rare cases - 12 g). The average duration of treatment is 7-10 days.

For prevention of postoperative infection - V / in 1 g for 0.5-1 hours before surgery, 0.5-1 g - during the operation and 0.5-1 g - every 8 hours during the first day after the operation.

Patient S. disorders of the kidney function KK 55 ml / min and more with KK 54-35 ml / min with KK 34-11 ml / min Kk 10 ml / min and less

Children 1 month and older - 25-50 mg / kg / day; for severe course infection The dose can be increased to 100 mg / kg / day. The multiplicity of administration is 3-4 times / day.

W. children with impaired kidney function The correction of the dosing mode is carried out depending on the values \u200b\u200bof the QC: when KK 40-70 ml / min - 60% of the average daily dose and introduce every 12 hours; for KK 20-40 ml / min - 25% of the average daily dose at intervals of 12 hours; for KK 5-20 ml / min - 10% of the average daily dose every 24 hours. All recommended doses are injected after the initial shock dose.

Preparation of injection and infusion solutions: 0.5 g of the preparation is dissolved in 2 ml of water for injection, 1 G is 4 ml of injection indices. For in / in bolus administration, the resulting solution is breed 5 ml of water for injection, then injected slowly for 3-5 minutes. For in / in drip administration, the drug is breeding 50-100 ml of 5% or 10% dextrose solution, 0.9% solution of sodium chloride, ringer solution, 5% sodium solution of bicarbonate.

During breeding bottles, it is necessary to vigorously shake up to complete dissolution.

Side effects

Allergic reactions:urticaria, chills, fever, rash, itching; Rarely - bronchospasm, zozinophilia, exudative multiform erythema, malignant exudative erythema (Stevens-Johnson syndrome), toxic epidermal necrolis (Layella syndrome), angioedema edema, anaphylactic shock.

From the sides of the digestive system:nausea, vomiting, diarrhea or constipation, meteorism, abdominal pain, dysbacteriosis, candidiasis gastrointestinal tract (including candidide stomatitis), violation of the liver function (increasing activity of hepatic transaminases, progress, hyperbilirubinemia), rare-stomatitis, glossitis, hepatitis and Cholestatic jaundice, pseudomambranous enterocolitis.

On the part of the blood formation organs:leukopenia, neutropenia, granulocyptopenia, thrombocytopenia, hemolytic anemia, reduced hematocrit, increase in prothrombin time.

From the urogenital system:violation of the kidney function (azotemia, increasing the level of urea in blood, hypercreatininemia), anal itching, itching of genital organs.

Local reactions:flebit, pain in the course of veins, soreness and infiltration in the place of the introduction.

Others: Superinfection, candidiasis.

Loop diuretics and drugs that block the channel secretion increase the concentration of cefazoline in plasma.

Aminoglycosides increase the risk of kidney damage.

Pharmaceutically incompatible with aminoglycosides (mutual inactivation). To prepare a solution for in / in administration (inkjet or drip), it is impossible to use lidocaine.

special instructions

Patients who have an anamnesis of allergic reactions to penicillins may have increased sensitivity to cephalosporin antibiotics.

With caution, the drug is prescribed to patients with gastrointestinal diseases (especially with colitis).

When using cefassoline, it is possible to appear positive direct and indirect Cumbas samples.

When applying cefasoline, it is possible to obtain a false positive reaction to glucose in the urine.

The safety of the use of the drug in premature children and children of the first month of life is not established.

Pregnancy and lactation

If necessary, applying the drug breast-feeding stop.

Childcare

Do not prescribe newborns.

With violations of the kidney function

FROM caution - Renal failure.

Patient S. disorders of the kidney function Requires a change in the dosing mode according to the values \u200b\u200bof the QC: KK 55 ml / min and more or at a concentration of creatinine in a plasma 1.5 mg% and less can be administered a full dose; with KK 54-35 ml / min or concentration of creatinine in a plasma 1.6-3.0 mg% can be administered a full dose, but the intervals between injections must be increased to 8 hours; with KK 34-11 ml / min or concentration of creatinine in plasma 3.1-4.5 mg% - 1/2 dose at intervals of 12 hours; for Kk 10 ml / min and less Or at a creatinine concentration in plasma 4.6 mg% and more - 1/2 of the usual dose every 18-24 hours. All recommended doses are introduced after the initial shock dose of 500 mg.

When violations of the liver function

FROM caution - liver failure.

Conditions of vacation from pharmacies

The drug is released by the prescription.

Terms and Storage Terms

The drug should be stored in an inaccessible place at a temperature not higher than 25 ° C. Shelf life - 2 years. Do not use the deadline specified on the package.

Description Cefasoline is based on officially approved application instructions and approved by the manufacturer.