"Papaverine", what helps this antispasmodic? The medicine effectively lowers the tone and contractile work of smooth muscles. The agent has an antihypertensive and analgesic effect. The drug "Papaverine" instructions for use prescribe to use for cholecystitis, renal colic, angina pectoris.

Composition and form of release

The medicine "Papaverine", from which it helps with cramps and colic to various groups of patients, is produced in the following forms:

1. Tablets with an active element content of 10 or 40 mg.
2. Solution for injection. It is sold in ampoules of 2 ml with 2% inclusion active substance.
3. Rectal suppositories, 20 mg.

The active element is papaverine hydrochloride, from which the drug helps patients according to indications. Auxiliary components, depending on the type of drug, are: disodium edetate, sugar, methionine, talc, stearin and other substances.

Instructions for use are included in the box with the preparation.

Pharmacological properties

The action of the drug "Papaverine", which determines its effectiveness, is due to the anticonvulsant, analgesic and antihypertensive properties of the active element. After using the medication, muscle tone decreases. internal organs, blood flow improves, arteries and blood vessels expand.

Instructions for use of the drug "Papaverine" indicates its ability to lower blood pressure. When taking large doses, a sedative effect is observed, intracardiac conduction is inhibited, and myocardial excitability decreases. In small quantities, the drug has a weak effect on the nervous system.

Solution, suppositories, tablets "Papaverine": what helps

The medicine is indicated for use when:

• spasms of the muscles of the abdominal organs;
• renal colic;
• for the treatment of hypertensive crisis, the drug "Papaverine" is also prescribed, from which it helps in the composition complex treatment;
• cholecystitis;
• spastic colitis;
• endarteritis;
• pylorospasm;
• angina pectoris;
• spasms of the peripheral vascular bed;
• urinary retention of spastic etiology;
• bronchospasm;
• a decrease in the lumen of the vessels of the brain of the head;
• decreased arterial renal flow.

The drug is used before surgical interventions on internal organs, when relaxation of the patient's smooth muscles is required.

• The drug "Papaverine": instructions for use

The tablets are taken orally 3-4 times a day. The dosage for adult patients is 0.04 - 0.06 g. "Papaverine" tablets are given to children in a volume calculated depending on age. One-time quantity is:

1. Up to 2 years - 5 mg.
2. Up to 4 years old - 5-10 mg.
3. Up to 6 years old - 10 mg.
4. Up to 9 years old - 10-15 mg.
5. Up to 14 years old - 15 - 20 mg.

How to use papaverine injections

The solution can be injected into muscle tissue or under the skin up to 4 times a day. A single dose is 1-2 ml. Intravenous injections are performed slowly, while the solution must be diluted in advance with 0.9% saline in a 1 to 1 ratio.

Application of candles

Suppositories are indicated for adult patients only. You can use Papaverine candles up to 3 times per knock.

Side effects

The drug "Papaverine" can provoke negative reactions of the body from the circulatory, cardiac, vascular, gastric, intestinal, nervous systems... TO adverse reactions include:

• pressure drop;
• nausea;
• drowsiness;
• AB - blockade;
• constipation;
• eosinophilia;
• ventricular tachycardia;
• bloating;
• allergies;
• an increase in the activity of hepatic transaminases.

If the dosage is violated, the patient may experience diplopia, weakness, drowsiness, and decreased pressure.

Contraindications

Means "Papaverin" instructions for use prohibit prescribing at:

• increased sensitivity of the patient to the components;
• low blood pressure;
• acute kidney failure;
• glaucoma;
• atrioventricular conduction;
• children under 6 months;
• elderly people.

The use of the drug "Papaverine" during pregnancy

According to the instructions, the effect of the drug "Papaverine" during pregnancy on the fetus is not fully understood. The provisions of the annotation recommend refraining from taking the medication. However, doctors have been prescribing this remedy for several decades. They set the dosage and duration of therapy individually for each patient.

In this case, any undesirable consequences not visible. Reviews of women expecting the birth of a child also indicate that there were no violations after using the product. Why do papaverine candles help during pregnancy? The main indication is uterine hypertonicity, which is the cause of premature birth and miscarriage.

Price and analogues

A similar antispasmodic effect is exerted by drugs: "" and "Drotaverine Hydrochloride". You can buy papaverine tablets for 10-15 rubles. The price of 10 injections is 40 rubles. You will have to pay 60 - 70 rubles for candles.

Conditions of release and storage

Papaverine refers to antispasmodic drugs prescription dispensing. Shelf life of tablets is 5 years, solution for injection is 24 months.

Papaverine hydrochloride Papaverine hydrochloride

Active substance

›› Papaverine

Latin name

Papaverini hydrochloridum

Pharmacological groups: Vasodilators
›› Myotropic antispasmodics

Composition and form of release

Substance for preparation dosage forms; in double-layer bags of 7 kg.

Characteristic

Flavourless white crystalline powder. Soluble in chloroform, moderately soluble in water, slightly soluble in alcohol 95%, practically insoluble in ether.

pharmachologic effect

pharmachologic effect- antispasmodic, hypotensive... Inhibits phosphodiesterase, promotes intracellular accumulation of cAMP. Lowers tone and reduces smooth muscle contractile activity.

Shelf life

Storage conditions

List B. In a dry, dark place at a temperature not exceeding 25 ° C.

. 2005 .

See what "Papaverine hydrochloride" is in other dictionaries:

PAPAVERIN HYDROCHLORIDE- Papaverini hydrochloridum. Properties. White crystalline powder slightly bitter in taste. It dissolves slowly in water (1:40), poorly in alcohol. Aqueous solutions(pH 3.0 4.5) sterilized at 100 ° C for 30 minutes. Release form. They release ... Domestic veterinary drugs

Active ingredient ›› Papaverine (Papaverine) Latin name Papaverine ATX: ›› A03AD01 Papaverine Pharmacological groups: Vasodilators ›› Myotropic antispasmodics Composition and release form Suppositories for rectal administration1 ... ... Dictionary of Medicines

PAPAVERIN (Raraverinum). An alkaloid found in opium. Currently, they are obtained synthetically. It is produced in the form of papaverine hydrochloride (Paraverini hуdro chloridum). In terms of chemical structure, it is 6.7 dimethoxy 1 hydrochloride (3.4 ... Dictionary of Medicines

GASTRITIS- honey. Gastritis is a lesion of the gastric mucosa with a pronounced inflammatory reaction in the case of an acute course or with morphofunctional rearrangement in the case of chronic course... Frequency 248.0 (registered patients with a diagnosis ... ... Disease Handbook

PANCREATITIS ACUTE- honey. Acute pancreatitis is an inflammatory necrotic lesion of the pancreas caused by enzymatic autolysis caused by various reasons. Etiology Diseases of the biliary tract (cholelithiasis, choledocholithiasis, stenosis ... ... Disease Handbook

Jaundice, mechanical- honey. Obstructive jaundice is a pathological syndrome caused by impaired outflow of bile from bile ducts... Frequency. Most common reasons cholelithiasis (29.2% of cases), malignant tumors(67.3% of cases). In the group of patients up to 30 ... ... Disease Handbook

Chronic recurrent disease, the main symptom of which is the formation of a defect (ulcer) in the stomach wall or duodenum... In foreign literature, this disease is usually referred to as "ulcer ... ... Medical encyclopedia

- (analgetica; Greek negative prefix a + algos pain) drugs that selectively weaken or eliminate pain. In therapeutic doses And. Page. oppress only pain sensitivity and do not disturb consciousness. Traditionally they distinguish ... Medical encyclopedia

Active ingredient ›› Bendazol * + Metamizole sodium * + Papaverine + Phenobarbital * (Bendazol * + Metamizole sodium * + Papaverine + Phenobarbital *) Latin name Andipalum ATX: ›› N02BB72 Metamizole sodium in combination with psychotropic ... ... Dictionary of Medicines

Active ingredient ›› Codeine + Morphine + Narcotine + Papaverine hydrochloride + Tebaine (Codeine + Morphine + Narcotine + Papaverine + Tebaine) Latin name Solutio Omnoponi pro injectionibus ATX: ›› N02AX Other opioids Pharmacological ... ... Dictionary of Medicines

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The site provides background information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. A specialist consultation is required!

Papaverine(Latin - papaverine) is a widespread medicinal substance, which has antispasmodic, vasodilatory and hypotensive effects. By origin and chemical structure, papaverine is alkaloid opium poppy, that is, it is obtained from poppy straw, but is not a narcotic substance.

Varieties, names, release forms and composition of Papaverine preparations

Papaverine is at the same time tradename certain medications, and international name(INN) active ingredient in many drugs. Preparations with the trade name "Papaverine" are one and the same with the active substance "papaverine". This substance is called either simply papaverine, or papaverine hydrochloride... Moreover, papaverine hydrochloride is the chemical name for papaverine, and from the point of view of a doctor or patient, there is no difference between these terms.

Currently in countries the former USSR drugs that contain only papaverine as an active ingredient are usually referred to simply as "papaverine". In some cases, letters or abbreviations may be added to the word papaverine, encoding the name of the manufacturer of the drug, for example, "Papaverine MS", "Papaverine Bufus", etc. However, in all cases we are talking about the same drug produced by different factories , but containing the active component papaverine.

In addition, there are multicomponent drugs with other names that simultaneously contain several active substances, among which there is papaverine. These are drugs such as Papazol, Andipal, Theodibaverine, etc. However, in this article we will consider exclusively monocomponent preparations containing only papaverine as an active substance and having the same name, respectively. In order to distinguish and not confuse the active substance and the name of the drug, we will write the first with a small letter, and the second with a capital letter.

Mono-component preparations containing only papaverine as an active substance are currently produced under the following commercial names:

• Papaverine;
• Papaverine Bufus;
• Papaverine MS;
• Papaverine hydrochloride.

All four drugs are synonymous and come in three dosage forms - oral tablets, rectal suppositories and injection. Suppositories are often called "papaverine suppositories", and the solution is often called "papaverine injections", "papaverine ampoules" or "papaverine injections".

Accordingly, the composition of the three dosage forms contains papaverine hydrochloride as an active substance in the following dosages:

• Tablets for adults - 40 mg;
• Tablets for children - 10 mg;
• Solution for injection - 20 mg per 1 ml;
• Rectal suppositories - 20 mg per suppository.

The composition of the auxiliary components for the same dosage form, for example, tablets, may vary depending on the manufacturer, so you should always carefully read it in the enclosed leaflet with instructions for use.

Since the pharmacological action of papaverine is multidirectional, it is simultaneously attributed to two groups of drugs, such as vasodilators (vasodilators) and antispasmodics... Accordingly, as an antispasmodic, Papaverine is used to treat functional disorders gastrointestinal tract, and as a vasodilator - in the treatment of erectile dysfunction.

Therapeutic effects of papaverine

Papaverine, by blocking the work of a number of enzymes, reduces tone and relaxes the smooth muscles of all internal organs. The fact is that the internal organs (stomach, intestines, blood and lymph vessels, bronchi, lungs, urethra, etc.) are equipped with exceptionally smooth muscles, due to the work of which their general tone increases or decreases. With an increase in tone, the organ contracts, that is, its spasm occurs, and when it decreases, on the contrary, relaxation and expansion of the existing lumen occurs.

For example, with an increase in the tone of the smooth muscles of the intestines, bronchi or gallbladder, the organs are strongly compressed, characteristic spastic pains appear and the movement of the contents along their lumens is impaired. That is, in the intestine, the movement of the food lump is delayed, bile stops flowing from the gallbladder, and the required amount of air cannot pass through the bronchi. In addition, any spasm of internal organs is accompanied by pain syndrome of varying intensity. Papaverine relieves spasm, relaxes organs, thereby restoring their function and relieving pain. Since the drug is not selective, it effectively relieves spasms and pains of any internal organ, and therefore is widely used. Basically, Papaverine has the same properties and therapeutic effects as the more widely known No-Shpa.

Papaverine has a relaxing effect only on internal organs, since it affects smooth muscles and does not affect striated muscles. The fact is that on the human body and in the heart there are only striated muscles, which have different properties and react to completely different stimuli and substances. Therefore, antispasmodics acting on smooth muscles do not affect the contractility of skeletal and cardiac muscles. Thus, Papaverine is able to relieve spasms and relax the muscles of internal organs without affecting the myocardium and body muscles.

Summarizing the described effects, the following main therapeutic effects of Papaverine can be distinguished:

• Relaxes smooth muscles and relieves smooth muscle spasms blood vessels, organs of the digestive, respiratory and genitourinary systems;
• By relaxing the muscles of the blood vessels and their subsequent expansion, it reduces blood pressure;
• High doses reduce the excitability of the heart muscle and slow down the conduction of the impulse through the heart;
• In high dosages, it has a sedative effect on the central nervous system.

Thus, Papaverine has two main pharmacological effects- antispasmodic (relieves spasm and relaxes smooth muscles) and hypotensive (lowers blood pressure).

Papaverine is rapidly absorbed into the bloodstream by any route of administration (tablets, rectal suppositories, intramuscular injections) and excreted by the kidneys. Half of the administered dose of the drug is excreted after 0.5 - 2 hours.

Papaverine (tablets and injections) - indications for use

The indications for the use of pills, injections and rectal suppositories of Papaverine are exactly the same, since regardless of the dosage form, the drug is absorbed into the blood and has systemic therapeutic effects.

Papaverine tablets, injections and suppositories are indicated for use in the following diseases and conditions:

• Spasms of smooth muscle elements of the gastrointestinal tract with various diseases, such as pylorospasm, colitis, cholecystitis, cholangitis, etc .;
• Cramping pains (for example, with colitis, flatulence, menstruation, irritable bowel syndrome (IBS), constipation, etc.);
• As part of complex therapy cholecystitis and renal colic as an anesthetic and spasm-relieving drug;
• Spasms and pains in the organs of the genitourinary system (cystitis, pyelitis, kidney stones or urethra, etc.);
• Bronchospasm;
• Cerebrovascular spasm;
• Spasm of peripheral vessels, for example, with endarteritis and other diseases;
• As part of the complex therapy of angina pectoris;
• As an auxiliary drug in pre-anesthetic preparation (premedication).

Papaverine (papaverine hydrochloride) - instructions for use

Consider the rules and nuances of using each dosage form of Papaverine (tablets, suppositories and injection solution) separately.

Papaverine tablets - instructions for use

The tablets should be taken orally, swallowing whole, without chewing, biting or crushing in other ways, but with a sufficient amount of water (about 200 ml). Papaverine can be taken regardless of food, and as needed, that is, when spastic pains or painful spasms occur. However, if there are spastic pains in the organs of the gastrointestinal tract, then it is better to take Papaverine 15-30 minutes before meals, so that the drug stops the symptoms, and the person can eat and drink calmly.

For spasms and spastic pains of internal organs, adults and adolescents over 15 years of age are recommended to take Papaverine 40-60 mg (1-1.5 tablets) 3-4 times a day. Children should be given tablets with a special pediatric dosage of 10 mg. Moreover, the dosage of Papaverine for children is determined by age:

• 6 - 24 months - 5 mg (1/2 baby tablet) 3 - 4 times a day;
• 2 - 4 years - 5 - 10 mg (1/2 - 1 children's tablet) 3 - 4 times a day;
• 5 - 6 years old - 10 mg (1 tablet for children) 3 - 4 times a day;
• 7 - years old - 10 - 15 mg (1 - 1.5 baby tablets) 3 - 4 times a day;
• 10 - 14 years old - 15 - 20 mg (1.5 - 2 children's tablets) 3 - 4 times a day.

The duration of therapy depends on the rate of disappearance of spastic pain or relief of organ spasm. In acute conditions, papaverine is usually taken for 2 to 5 days, and in chronic conditions, 1 to 3 weeks.

Papaverine in ampoules - instructions for the production of injections

The ampoules contain a sterile 2% solution of Papaverine, ready for administration, containing 20 mg of active substance in 1 ml. Since the ampoule contains 2 ml of solution, the total dosage of Papaverine in a whole ampoule is 40 mg, which is equivalent to one adult tablet. The solution can be administered intact subcutaneously or intramuscularly, and after reconstitution - intravenously.

For adults and adolescents over 10 years of age, the solution is administered 2 to 4 times a day, and for children under 10 years of age - 2 times a day. A single dosage of Papaverine is determined by age:

• 6 - 24 months - 0.25 ml of solution 2 - 4 times a day;
• 2 - 4 years - 0.25 - 0.5 ml of solution;
• 5 - 6 years old - 0.5 ml of solution;
• 7 - years old - 0.5 - 0.75 ml of solution;
• 10 - 14 years old - 0.75 - 1 ml of solution;
• 15 years and older - 1 - 2 ml of solution.

That is, in the indicated dosages, the solution is administered 2 times a day to children under 10 years old, and 2 to 4 times a day to adolescents over 10 years old and adults.

For subcutaneous or intramuscular administration, the injection site is selected first. Intramuscularly, it is optimal to inject the solution into the upper lateral outer surface of the thigh or the outer upper part shoulder, and subcutaneously - in the area around the navel. Before the injection, the skin is wiped with an antiseptic, after which the required amount of solution is drawn into the syringe and injected into the prepared place. For intramuscular injection, the needle is inserted deep into the tissue perpendicular to the surface of the skin. And for subcutaneous injection first, grasp about 1 cm of the skin with your thumb and forefinger, making a fold out of it. After that, the needle of the syringe is set at approximately 45 ° to the skin surface and inserted into this fold. The solution is released into the tissue and the needle is carefully removed, after which the injection site is again wiped with an antiseptic. Each time, the solution should be injected at a point that is at least 1 cm away from other marks from past injections.

For intravenous administration you must first dilute the required amount of Papaverine in 10 - 20 ml of saline. Then this mixture is injected intravenously, slowly. Intravenous injections should be made only in a hospital setting, and subcutaneous or intramuscular injections can be done at home on their own, if the person has mastered their technique and does not feel fear.

Papaverine - instructions for the use of suppositories

Suppositories are inserted into the rectum by gently pushing with the index finger through the anus. Candles should be inserted with clean hands that have just been washed with soap or with sterile gloves. The dosage of suppositories for various diseases accompanied by spasms and spastic pains is determined by age and is 1 - 2 suppositories 2 - 3 times a day for adults, and 1 suppository 2 times a day for children over 10 years old. For children under 10 years old, the candles are cut into 2 or 4 equal parts and injected with these pieces containing the required amount of the active substance. So, children under 4 years old are injected with a quarter or half of a candle, and from 5 to 10 years old - half a suppository, 2 times a day.

Dosage for various diseases

The dosage of Papaverine in all dosage forms is the same for various diseases and conditions, but differs only depending on the age of the person using the drug. So, single dosages of solution, suppositories and papaverine tablets for people of different ages are as follows:

• 6 - 24 months - 5 mg each;
• 2 - 4 years - 5 - 10 mg each;
• 5 - 6 years - 10 mg each;
• 7 - years - 10 - 15 mg each;
• 10 - 14 years old - 15 - 20 mg each;
• Over 14 years old - 20 - 60 mg.

At the same time, Papaverine in the indicated dosages is taken a different number of times a day, depending on the dosage form - tablets 3 to 4 times, the solution is injected 2 to 4 times a day, and suppositories - 2 to 3 times. Moreover, children under 6 years old should use Papaverine the smallest of the permissible amounts once a day, and at the age of 6 years, the frequency of taking the drug is determined by the person's condition, and can be maximum.

The maximum permissible single dose of Papaverine is the highest dose indicated for each age, multiplied by four. That is, for an adult, the maximum permissible single dosage is 60 * 4 = 240 mg, for a child from 10 to 14 years old - 20 * 4 = 80 mg, etc. The maximum allowable daily dosage is equal to the maximum single dose, multiplied by three.

special instructions

For any diseases that are indications for the use of Papaverine, you can choose the dosage form that seems most convenient at the current time. For example, if it is most convenient for a person to take pills, then this particular form should be chosen.

If you need a quick achievement therapeutic effect, especially in the early days of an exacerbation of the disease, then injections should be used. After 2 to 3 days, if a person can swallow, injections should be replaced with tablets or rectal suppositories. It is not recommended to perform the entire course of therapy using subcutaneous or intramuscular injections, since this entails greater risks compared to taking pills. Therefore, injections should be given only if suppositories and tablets cannot be used for some reason. In general, doctors recommend being guided by a simple rule in choosing the form of the drug - always use either suppositories or tablets, and use injections only if necessary to obtain a quick therapeutic effect, but replace them with tablets or suppositories as soon as possible.

If a person suffers from gastrointestinal spasms, then he can use Papaverine both in suppositories and in tablets, based solely on personal preference. However, it should be remembered that when using papaverine suppositories, the clinical effect occurs faster than from tablets. Therefore, if you need to get a quick effect, it is better to use candles. It is also recommended to choose suppositories if a person, for some reason, cannot swallow pills.

With spastic pain in the organs of the urinary system, Papaverine suppositories are the best option, since when they are introduced into the rectum, the active substance very quickly reaches the affected tissues and has a powerful therapeutic effect. If, for some reason, suppositories are impossible or difficult to enter into the rectum, then they should be replaced with tablets.

In children, it is recommended to use Papaverine in the form of suppositories or special children's tablets with a low dosage of the active substance of 10 mg. Children should not be given halves or quarters of Papaverine tablets for adults, which contain 40 mg of the active substance.

Papaverine is not a drug intended for long-term course use, therefore it is used exclusively for a one-time relief of spastic pain against the background of an exacerbation of a disease or condition. This means that pills, suppositories or injections of Papaverine can be used on their own for 2 to 3 days, after which an improvement should necessarily appear, expressed in a decrease in spastic pain and discomfort in the area of ​​localization of the pathological process. If there is no improvement, then you should immediately consult a doctor, as this may indicate the development of severe surgical pathology, for example, appendicitis, bleeding, peritonitis, etc.

As prescribed by a doctor, Papaverine is usually used for 7-14 days or a little longer, until the complete relief of painful spastic pains. If a person has long been suffering from any chronic disease, for example, cholecystitis, then he knows very well the symptoms of its exacerbation and the dynamics of improvements that occur while taking papaverine, and therefore can independently determine the duration of taking the drug.

If a person is faced with spastic pain for the first time, then the first course of therapy should be carried out exclusively under the supervision of a doctor and independently record their own feelings, as well as positive dynamics. In the future, with an exacerbation of the disease, the relief of spasms will also be performed by antispasmodics, and their dynamics will not fundamentally differ from that which was recorded for the first time. And a person who remembers well the dynamics of reducing spastic pain and normalizing the condition, during periods of exacerbations in the future will be able to independently control how well and how well the treatment is going without visiting a doctor or going to the hospital. In addition, he will be able to record any distinctive manifestations of the dynamics of treatment and report them to the doctor, who, in turn, will specifically look for their cause and deal with the problem of diagnosing combined or atypical pathology.

Overdose

An overdose of papaverine is possible and is manifested by the appearance of double vision, weakness, drowsiness and a decrease in pressure. For the treatment of an overdose, the stomach is washed, after which the person is given sorbents (activated carbon, Polysorb, etc.) and milk, and the pressure is maintained at a normal level.

Interaction with other medications

Papaverine reduces the therapeutic effect of Levodopa and Methyldopa.

In addition, No-Shpa with Papaverine is often used to prepare the cervix for childbirth, for which women take 1 tablet or inject 1 suppository of each drug 2 times a day for 2 weeks before the expected date of birth. This practice is widespread, but these preparations for preparing the cervix do more harm than good, because just before childbirth, when the uterus must actively contract and prepare, it is artificially "inhibited" by antispasmodics, relaxing muscles and reducing tone. As a result of the use of No-Shpa with Papaverine "to prepare the cervix", the likelihood of weakness in labor increases and, accordingly, the use of labor stimulation, labor induction and the imposition of forceps or vacuum. That is, it is not the preparation of the cervix that occurs, but the oppression of labor.

The use of No-Shpy with Papaverine does not reduce the risk of rupture, which in most cases depends only on the competent management of childbirth by a doctor. And to prepare the cervix for childbirth, which is carried out only with prolonged gestation or the need for urgent delivery against the background of a threat to the mother's life, completely different drugs (Prostin, etc.) and non-pharmacological agents (kelp, Foley catheter, etc.) are used.

Papaverine for children

Papaverine in any dosage form can be used in infants from three months of age. The instructions usually indicate that the drug is approved for use from 6 months, but practicing pediatricians, on the basis of many years of observation of the use of Papaverine, consider it justified and safe to use it from 3 months. After all, Papaverine is also part of the popular drug Omnopon, which is used for pain relief in childbirth.

In babies of the first year of life, Papaverine is used mainly to relieve spastic pain and intestinal colic, and in older children - to relieve bronchospasm, as well as in the complex therapy of pancreatitis, hepatic colic and urethral spasms. In addition, if the child has a high fever and white, cold hands and feet, then Papaverine is given for the purpose of vasodilation 15 to 20 minutes before the antipyretic drug. In a situation where the hands and feet are cold, and the temperature is very high, antipyretic without first taking an antispasmodic (Papaverine, No-Shpy, Drotaverin, etc.) will not work, since the constricted, spasmodic vessels will not give off excessive heat and cool the body ...

Papaverine in children is used in all three dosage forms at dosages depending on age:

• 6 - 24 months- 5 mg (1/2 child's tablet, 0.25 ml of solution or 1/4 suppository) 2 times a day;
• 24 years- 5 - 10 mg (1/2 - 1 children's tablet, 0.25 - 0.5 ml of solution or 1/4 - 1/2 suppositories) 2 times a day;
• 5 - 6 years old- 10 mg (1 children's tablet, 0.5 ml of solution or half a candle) 2 times a day;
• 7 - 9 years old- 10 - 15 mg (1 - 1.5 children's tablets, 0.5 - 0.75 ml of solution or 1/2 - 2/3 candles) 2 - 3 times a day;
• 10 - 14 years old- 15 - 20 mg (1.5 - 2 children's tablets, 0.75 - 1 ml of solution, 2/3 - 1 candle) 2 - 3 times a day;
• Teenagers over 14 years old- 20 - 40 mg each (1 adult pill, 1 - 2 ml of solution or 1 - 2 suppositories) 3 - 4 times a day.

Children need to be given only special children's papaverine tablets, which contain 10 mg of the active substance, and not be broken into small parts by adults. When using a solution, small syringes should be taken in order to accurately measure the required amount of the drug. And when using candles, they must be cut into pieces along, not across. In small children, it is recommended to use Papaverine in suppositories or solution, since they still have difficulty swallowing tablets. In older age groups, any convenient dosage form can be used.

Papaverine from pressure

Papaverine dilates blood vessels and moderately lowers blood pressure; however, it is not used as a specific antihypertensive drug for long courses of treatment. Papaverine in combination with Dibazol is usually injected for hypertensive crisis

• Hypersensitivity to drug components;
• AV block;
• Liver failure;
• Elderly age over 65;
• Children under 6 months of age.

In addition to these contraindications, there are a number of conditions in which Papaverine should not be used until recovery or complete rehabilitation. These conditions are temporary restrictions on the use of the drug, since after their cure or stabilization of the condition, Papaverine can be used with caution. So, restrictions on the use of the solution, suppositories and tablets of Papaverine are the following conditions:

• Traumatic brain injury suffered during the last 6 months;
• Shock conditions;
• Chronic renal failure 1. Biospa tablets;
  2. Vero-Drotaverine tablets;
  3. Droverin injection, tablets;
  4. Drotaverin MS, Drotaverin forte, Drotaverin-UBF, Drotaverin-Teva and Drotaverin-FPO - tablets;
  5. Drotaverin-Ellara injection solution;
  6. Nikoverin tablets;
  7. No-Shpa tablets and injection;
  8. No-shpa forte tablets;
  9. Nosh-Bra injection and tablets;
  10. Papazol and Papazol-UBF tablets;
  11. Platyphyllinum with papaverine tablets;
  12. Ple-Spa tablets;
  13. Spazmol injection and tablets;
  14. Spazmonet and Spazmonet forte tablets;
  15. Spazoverin tablets;
  16. Spakovin injection and tablets.

  The drug "Papaverine" in injections belongs to the group of myotropic antispasmodics. This remedy has a relaxing effect on the smooth muscles of the internal organs and vascular walls. Papaverine is widely used due to its affordable cost and safe medicinal properties.

  Active substance

  "Papaverine" is an alkaloid of the opium poppy. Despite the fact that the medicine is made from poppy straw, it is not a narcotic drug. Papaverine injections are prescribed to combat muscle hypertonia in various body systems, including the gastrointestinal tract, respiratory, cardiovascular and genitourinary systems.

  "Papaverine" is at the same time a trade name medicinal product, and the international name of the active ingredient. Papaverine hydrochloride is an active substance that helps to dilate the arteries and accelerate blood flow. This remedy is often used to lower blood pressure, since the drug has a pronounced hypotensive effect.

  The medicine quickly enters the bloodstream: Papaverine reaches the site of the main effect in 20-30 minutes, while its concentration is evenly distributed throughout the body. The active ingredient is broken down in the liver, which eliminates the likelihood of accumulation of the substance with repeated use. The antispasmodic leaves the body with urine.

  Who is appointed

  This drug is available not only in injections. "Papaverine" is sold in tablets and in the form rectal suppositories... Indications for the use of the drug, regardless of the form of release, do not change. The active substance is absorbed into the patient's blood in exactly the same way and has a systemic therapeutic effect.

  In the predominant number of cases, "Papaverine" is prescribed for the complex treatment of diseases and conditions such as endarteritis, bronchospasm, pylorospasm, cholecystitis, angina pectoris and spastic colitis. It is recommended to use this medication:

  • in order to prevent spasms of muscle tissues of the smooth structure of internal organs - we are talking about inflammation of the gallbladder, irritable bowel syndrome, spasms of the stomach, respiratory organs;
  • for relief of acute pain syndrome in renal and hepatic colic;
  • with systemic therapy of impotence, erectile dysfunction against the background of diseases of the small organs, disorders of vascular etiology;
  • to eliminate spasms in vascular pathologies, accompanied by involuntary contraction of the arteries of the brain, upper and lower extremities.

  Sometimes injections of "Papaverine" are given to patients before the operation. The drug is used as an adjunct agent that helps prepare the patient for the introduction of anesthesia - to reduce the degree of anxiety and enhance the effect of anesthesia.

  

  Instructions for the use of "Papaverine" in injections

  The drug produced in ampoules is a sterile solution of papaverine hydrochloride 2%, ready for parenteral administration. Each 2 ml ampoule contains 40 mg of active ingredient - this amount is equivalent to a single dose for an adult. The same amount of papaverine hydrochloride is contained in a tablet.

  When using a whole undiluted solution, the drug can be administered only subcutaneously or intramuscularly. After dilution, an intravenous injection of "Papaverine" is allowed. The dosage depends on the age of the patient:

  • adults and adolescent children can enter no more than 2 ml of medication at a time, while the maximum daily dose is 4-8 ml;
  • children 7-10 years old are allowed to give 0.5-0.75 ml of the drug no more than twice a day;
  • babies from six months to two years old - 0.25 solution up to four times a day;
  • children 2-4 years old - up to 0.5 ml of medicine twice a day;
  • children from 4-7 years old - 0.5 ml no more than two times.

  Injection technique

  With subcutaneous or intramuscular injection, you first need to determine the injection site. How to do Papaverine injections? In this case, the technique is practically no different from the parenteral administration of other drugs. The best place for intramuscular injection, the upper lateral outside surface the thighs or the upper outer part of the shoulder, and for the subcutaneous, the umbilical region.

  Before entering the tissue with a needle, the skin around the injection site must be treated with an antiseptic. Then the required amount of "Papaverine" is drawn into the syringe and injected intramuscularly into the prepared area. It is important that the needle goes deep into the tissue, making a right angle with the skin surface.

  If there is a need to perform a subcutaneous injection of "Papaverine", then the injection should be done differently. First, you need to grab approximately 1 cm of the skin fold with two fingers, then set a syringe at an angle of 45 degrees to the surface of the epidermis and inject the solution into the fold. As soon as all the medicine is injected, the needle is carefully removed and a cotton pad with an antiseptic is tightly applied to the injection site. If it is necessary to repeatedly inject the solution with each subsequent injection, one should step back from the previous injection marks by 1-2 cm.

  

  For intravenous infusion, the drug is diluted in the required amount with sodium chloride solution, then the resulting mixture is slowly injected into a vein in the arm. It is advisable to make such injections within the walls of a hospital. At the same time, subcutaneous and intramuscular injections The patient is allowed to put "Papaverine" on his own at home, if he owns the described technique.

  How to give in childhood

  "Papaverine" in ampoules, tablets and suppositories can be used to treat infants from the age of three months. Despite the fact that the instructions contain a contraindication to the use of this drug for children under six months of age, most domestic pediatricians consider taking the drug justified and safe from three months. The doctors' arguments are based on long-term observations of the use of "Papaverine". In addition, its active ingredient is part of "Omnopon" - a medicine that is intended for women in childbirth. The drug based on papaverine hydrochloride has an analgesic effect and helps to transfer childbirth easier.

  For children of the first year of life, the drug is prescribed mainly for the relief of spastic pain syndrome, intestinal colic. At an older age, "Papaverine" in ampoules can be used to relieve bronchospasm, be an element of the complex treatment of diseases of the pancreas, liver, urinary tract.

  If you are going to give a child an injection, it is advisable to draw a solution from an ampoule with a small syringe, which will allow you to accurately measure the required amount of medicine. The dosage of the drug for young patients is determined by the doctor.

  If we talk about pills "Papaverine", then they should be given to children in a special dose. The so-called children's "Papaverine" is produced, one pill of which contains 10 mg of the active ingredient. In the absence of tablets in the children's dosage, you can find another way out: calculate the dosage and divide the adult pill into small parts. If the child has been prescribed rectal suppositories, they can also be divided into two or four parts, but you need to cut it not across, but along the candle.

  

  Tablets "Papaverine" are rarely prescribed to children under two years old, like any other drugs in tablet form: babies can hardly swallow bitter pills. Doctors are more likely to prescribe suppositories and injection solutions. The action of "Papaverine" in injections is in no way inferior to the therapeutic effect achieved when taking pills, but, on the contrary, even surpasses it. In the absence of an opportunity to give an injection, a rectal suppository is placed on the child. In older and adolescent years, you can use any of the dosage forms of this drug.

  Features of use during pregnancy

  In the annotation to this drug, the manufacturer notes that the effect of the drug during pregnancy has not been studied. At the same time, in practice, "Papaverine" has been used for a long time for various health problems in expectant mothers without any consequences.

  Obstetricians-gynecologists everywhere prescribe this antispasmodic during pregnancy. In the reviews about "Papaverine" in injections, women note that experts call gestosis and hypertonicity of the uterus, which in itself is a threat of termination of pregnancy, as an indication for its appointment. Specialists, prescribing a medicine for expectant mothers at any stage of pregnancy, as a rule, pursue the following goals:

  • relax the muscles and reduce muscle tone;
  • improve blood supply to the fetus and pelvic organs;
  • reduce performance blood pressure.

  Why are Papaverine injections prescribed? Women carrying a baby can use this drug in the presence of the same diseases and conditions that are indications for using the product in the absence of pregnancy.

  "Papaverine" in candles or injections - which is better?

  For pregnant women, the drug is often prescribed in the form of rectal suppositories to reduce uterine tone. Suppositories are injected into the rectum, one piece 2-4 times a day, depending on the doctor's prescription. The drug is administered with clean hands, previously washed with antibacterial soap.

  

  With hypertonicity of the uterus, suppositories are a more suitable form of the drug, since they provide a quick and targeted supply of the desired concentration of the active substance. On the other hand, knowing how long the Papaverine injection lasts, it may seem that an injection is a preferable option. Antispasmodic effect after the injection occurs in about half an hour, and in order for the suppositories to take effect, it takes at least two hours. What to appoint in a particular case - suppositories or injections, the doctor must decide.

  For any other violations, pregnant women are advised to take pills in the same dosage as injections of "Papaverine". The indications for taking the drug, which are most often found in expectant mothers, are renal colic and stomach cramps.

  "No-Shpa" and "Papaverine" - a dangerous combination

  This drug complex is often used to prepare the cervix for the upcoming birth. "No-Shpu" and "Papaverine" are administered twice a day for two weeks before the expected date of birth of the baby. You can use not only injections, but also tablets, suppositories.

  Many pregnant women are prescribed these drugs in combination with each other. This is a very common practice, but in fact, these means for preparing the cervix do more harm than good to a woman. Before labor, the uterus must be actively contracted and prepared for childbirth, and instead of stimulating its contractions, the process is artificially stopped by antispasmodics, which relax the muscles and reduce the tone. The result of the use of "No-Shpy" with "Papaverine" is a weak labor activity, which will subsequently be the basis for the use of labor-stimulating, labor-stimulating drugs, the use of obstetric forceps or vacuum.

  In fact, "Papaverine" together with "No-Shpa" inhibits generic activity. The opinion that these drugs supposedly help prevent tissue rupture in a woman is erroneous. This moment depends solely on the experience and qualifications of the obstetrician-gynecologist. In modern clinics, such a combination of drugs has not been used for a long time. If necessary, to prepare the cervix for childbirth, the woman is prescribed other drugs and methods (for example, "Prostin", kelp sticks, Foley catheter). The doctor may decide to intervene after the fortieth week of pregnancy or, if necessary, urgent delivery due to the threat to the woman's life.

  

  Analgin plus Papaverine plus Diphenhydramine

  The classic lytic mixture with powerful antipyretic properties is an injection of "Analgin" with "Papaverine" and "Diphenhydramine". What does this medication cocktail help with? The mixture is intended for rapid decline high temperature. Especially efficient use drugs is for the so-called cold hyperthermia - a condition in which a person has a strong fever, but the limbs remain cold and pale. Against the background of cold hyperthermia, the risk of febrile seizures increases in children.

  "Analgin" in combination with "Diphenhydramine" knocks down the temperature, and "Papaverine" is usually given to dilate blood vessels. The antispasmodic is administered 15-20 minutes before the antipyretic agent. If the patient has icy limbs at a high temperature of the whole body, by itself, "Analgin" with "Diphenhydramine" may not be effective enough. Without first taking an antispasmodic, constricted vessels are not able to give off excess heat and cool the body.

  "Analgin" with "Diphenhydramine" and "Papaverine" is often used in inpatient surgery departments. This medicinal blend helps relieve pain postoperative period, stop inflammation and lower body temperature. In addition, other drug combinations can be used. For example, “Papaverine” together with “Diphenhydramine” is an effective analgesic combination for people with postoperative spastic pain, and with “Analgin” it is a simplified variation of the above-described lytic mixture.

  High pressure

  The hypotensive property of "Papaverine" is explained by its ability to moderate dilation of blood vessels. However, the drug is not suitable as a specific antihypertensive agent for a long course of treatment. This is also stated in the instructions for the use of "Papaverine" in injections. In combination with "Dibazol", this agent is administered parenterally for hypertensive crisis. This drug mixture helps to quickly reduce blood pressure, but cannot be used as a drug for systemic treatment... After relief, the patient should see a doctor. The specialist will select another drug for the patient for permanent use.

  

  Are there any chances of side effects?

  Papaverine hydrochloride preparations are considered relatively safe. Side effects from Papaverine injections most often occur on the background of allergies or adverse reactions from the gastrointestinal tract. According to reviews, this drug can cause:

  • redness on the skin;
  • small itchy rash;
  • swelling;
  • constipation;
  • nausea;
  • bloating;
  • disturbances of intestinal peristalsis.

  In addition, "Papaverine" has antihypertensive properties, which means that people with reduced pressure it is necessary to take the drug with extreme caution. In case of exceeding the daily volume of the drug or overdose, the activity of hepatic enzymes increases, which leads to eosinophilia. Some patients report drowsiness, dizziness, hyperhidrosis. If the solution is injected too quickly into the vein, violations are possible heart rate and the development of atrioventricular block.

  Symptoms such as double vision, weakness, and increased fatigue may indicate a severe overdose. You can get rid of them by conducting detoxification therapy, which involves washing the stomach, taking sorbents and maintaining blood pressure.

  About contraindications

  All restrictions associated with the use of "Papaverine" apply to any form of drug release. This remedy is contraindicated in diseases and conditions such as:

  • high sensitivity to drug components;
  • atrioventricular heart block;
  • glaucoma;
  • chronic liver failure;
  • over 65 years of age and under 6 months.

  In addition to absolute contraindications, it is worth noting a number of other conditions in which it is not recommended to give injections with "Papaverine":

  • traumatic brain injury suffered during the last six months;
  • shock state;
  • chronic renal and adrenal insufficiency;
  • hypothyroidism;
  • hyperplasia prostate;
  • tachycardia.

  

  Popular analogues

  The drug-synonym, identical in composition with "Papaverine" does not exist. At the same time, in pharmacy chains, you can easily find analogues of this agent containing several active ingredients, one of which is papaverine hydrochloride. There are also many medicines, which, like Papaverine, belong to the group of antispasmodics, have the same therapeutic effect, but they contain completely different active substances. The following drugs in the form of a solution for injection are considered to be analogues of Papaverine:

  • "Droverin".
  • "Nosh Bra".
  • "No-Shpa".
  • "Spazmol".
  • "Spakovin".

  How patients respond to the drug

  Most of the responses that are dedicated to Papaverine come from pregnant women. Comments from non-pregnant patients and men are mostly positive. People note that the drug quickly relieves sudden and sudden spasms, especially in the abdomen or pelvis. Patients like the cheapness and widespread availability of the drug - it can be bought at any pharmacy for less than 100 rubles.

  "Papaverine" is effective for spasms on the background of hypertonicity in pregnant women. Thanks to this particular drug, many women managed to bypass the threat of miscarriage and give birth to a baby on time.

  As for negative reviews about Papaverine injections, they are usually written by patients who have encountered side effects from the use of the medication. The appearance of weakness, dizziness and drowsiness associated with a drop in blood pressure is often noted. In addition, the pricks have a number of disadvantages to use. An injection can only be made within the walls of a medical facility, while a pill can be drunk anywhere at any convenient time. However, it is the injections that cause a quick response of the body, help in difficult and critical situations when patients require intensive medical care.

  Papaverine tablets are antispasmodic drugs used in medicine for various pathologies to relieve smooth muscle tone, eliminate spasms. The drug has a fairly quick action, is used in diseases of the digestive, urinary system, in the complex therapy of diseases of the cardiovascular, respiratory system and for the treatment of other conditions. The medicine has a mild hypotensive, analgesic effect, it is prescribed for adults and children.

  Composition of the preparation

  The composition of papaverine tablets includes a medicinal substance such as papaverine hydrochloride. Each tablet contains 10 mg of the active ingredient and excipients (stearic acid, talc, sugar, potato starch).

  Release form

  Tablets are one of the forms of papaverine release. In addition, the drug is produced in the form of rectal suppositories and ampoules with a solution for injection. Suppositories and injections have the same effect as a remedy for oral administration... Tablets are available in 10 pieces in one blister, placed in a cardboard box. Each package contains instructions for the use of papaverine tablets, from which you can find out detailed information about the medication.

  pharmachologic effect

  Consider what papaverine tablets are used for and what effect the drug has on the body. For adults and children, medication is prescribed to eliminate spasms and pain at various conditions... In addition, the medicine has an easy vasodilating action, due to which it can lower blood pressure.

  Tablets help relieve spasm of smooth muscles of the uterus, stomach, intestines, gallbladder, bronchi, larynx, kidneys, Bladder, blood vessels and some other organs.

  After the penetration of the active component into the blood, the activity of the phosphodiesterase enzyme is inhibited, which leads to a decrease in the amount of calcium in the human body, as a result of which the ability of smooth muscles to contract is reduced and this process slows down.

  Important! Despite the ability of the drug to relax smooth muscles, the motor activity of a person after taking the drug is completely preserved.

  Indications

  The drug should be taken only with the permission of a doctor. It is strictly forbidden to independently carry out treatment with this tool, since it has some contraindications. Papaverine tablets are recommended for the treatment of the following conditions:

  • renal colic;
  • inflammatory process gallbladder, accompanied by spasm and pain;
  • spastic colitis;
  • hepatic colic;
  • to relieve the tone of the uterus;
  • in the complex therapy of bronchospasm;
  • treatment of angina pectoris, recovery after a heart attack, stroke.

  Papaverine eliminates spasm, has a mild analgesic effect

  Most often, Papaverine is prescribed as a complex therapy, for self-treatment the drug is used less often, since it only relieves the symptoms of a particular pathology.

  Contraindications

  Papaverine should be used in strict accordance with the instructions for use or according to the scheme prescribed by the doctor. Violation of the method of administration and dose of the drug can cause serious complications and side effects.

  Medication contraindications:

  • child's age up to six months;
  • elderly age... Among patients who have reached 65 years of age, the agent is recommended to be used under the strict supervision of a specialist;
  • persistent hypotension;
  • Availability allergic reaction on the active ingredient of the drug or its excipients;
  • precoma or coma;
  • violation of atrioventricular conduction;
  • glaucoma.

  Papaverine tablets cannot be combined with some medications, therefore, before using it, you should consult your doctor and tell him if you have taken any medications before.

  Dosage and methods of administration

  You need to take Papaverine according to the scheme selected by the doctor based on the patient's diagnosis. The tablets are intended for oral administration. It is recommended to drink the medicine with water. The standard dosage regimen for adults is 3 tablets throughout the day. For children, the dosage is 1-2 tablets, depending on weight, age and other individual characteristics. The duration of therapy is selected for each patient separately.

  
  The dose and dosage regimen of the drug are selected by the doctor.

  Use by pregnant women

  How to take the medicine for women in position? Papaverine during pregnancy is prescribed to patients by the leading physician if there are indications such as increased uterine tone, high blood pressure and some other conditions accompanied by smooth muscle spasm. The dose of the drug is selected individually, usually 3 tablets throughout the day. The duration of treatment depends on the symptomatology and the shown therapeutic effect. In late pregnancy, the drug is used to lower blood pressure in uncomplicated gestosis.

  Important! Every woman should strictly adhere to the doctor's recommendations, observe the dosage and the regimen of the drug.

  Papaverine in Pediatrics

  From what and in what dosage is the remedy prescribed for small patients? For children, Papaverine is prescribed from six months of age, if there is a medical indication for this. Patients under 4 years of age are usually prescribed half a tablet 1-2 times a day. From 4 to 6 years old - 1 tablet, from 6 to 9 - 1.5-2 tablets. The duration of treatment for children is selected by the doctor depending on the diagnosis and clinical picture the patient.

  Side effects

  Papaverine has predominantly positive reviews. Side effects are extremely rare. The reason for the negative consequences is the violation of the dosage and the drug intake regimen.

  The main side effects while taking the medication:

  • nausea;
  • rarely vomiting;
  • a strong decrease in pressure;
  • rash on the body of an allergic nature;
  • eosinophilia;
  • excessive sweating;
  • dyspeptic disorders;
  • heart block.

  
  TO side effects include headache, nausea and other manifestations

  Taking too large a dose of the drug can cause disruption of the heart, drowsiness, double vision. If these symptoms appear, the patient should be immediately taken to the hospital, where gastric lavage and other medical activities.

  Analogs

  Papaverine's analogs, similar in their indications and field of application, are as follows:

  • Riabal - indicated for patients with organ diseases digestive system accompanied by pain and smooth muscle spasm. The drug is widely used for diseases of the urinary system;
  • - antispasmodic medication, which has a mild analgesic, vasodilator, hypotensive effect. Among the indications for the use of the drug are pathologies that cause spasms of blood vessels, exacerbation of hypertension, diseases of the digestive system, accompanied by spasm, and other conditions. The drug is produced in the form of tablets and a solution for intravenous administration;
  • Platyphyllin is an agent that has a sedative, antispasmodic, analgesic effect on the body. The medicine is used for stomach cramps, gastritis, ulcers, acute and chronic pancreatitis, cholecystitis, bronchospasm, as well as to lower blood pressure in hypertension and other diseases of cardio-vascular system;
  • No-Shpa is a widely used drug used as an adjunctive therapy for many pathologies. No-Shpa is prescribed to eliminate spasms of internal organs and blood vessels. The medicine helps to relieve pain in case of gastrointestinal tract pathologies, diseases of the respiratory system, heart and blood vessels, diseases of the genitourinary system and other organs;
  • GastroComfort is an herbal medicine that includes caraway seeds, dill, fennel and other ingredients. The remedy is prescribed for patients with diseases of the digestive system. Among the main indications are pain, stomach and intestinal cramps, flatulence and other manifestations.

  
  Dibazol is one of the analogues of Papaverine

  Important! Each of the analogs has its own contraindications, so they can be used only with the permission of a doctor.

  Drug interactions

  In combination with other medications, the effect of Papaverine may increase or, conversely, decrease.

  Enhance the action of the drug:

  • barbiturates;
  • Procainomide;
  • Quinidine;
  • Reseprin;
  • tricyclic antidepressants.

  Reduce action:

  • Levopoda;
  • Methylpoda.

  Before using Papaverine, you should inform your doctor about any drugs that are taken by the patient or taken the day before.

  The medication Papaverine is prescribed exclusively by a doctor. The specialist selects the dose and dosage regimen. The course of therapy usually lasts from 7 to 14 days until the pain is completely eliminated.

  Give medicine to children with extreme caution. If the child has not learned to swallow the pill, it is recommended to crush it into powder, mix it with a little water, and give it to the baby.

  
  It is strictly forbidden to combine Papaverine with alcoholic beverages

  With acute pain syndrome caused by severe diseases of the gastrointestinal tract, respiratory system and cardiovascular system, papaverine tablets should be replaced with injections.

  The tool does not affect concentration and memory, therefore it can be prescribed to patients with different professional activities.

  Terms of sale and price of funds

  From the pharmacy, the drug is dispensed by prescription, as it refers to myotropic antispasmodics. It is recommended to store the medicine when room temperature in a protected area from children. The approximate cost of Papaverine tablets is from 25 to 35 rubles.

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