Cheap analogues Flemoklav Solutab: a list with reviews and prices

The development of inflammatory processes caused by infection requires antibiotic treatment. Among the multitude pharmaceuticals This group is distinguished by Flemoklav Solutab. The medicine has positive reviews, however, sometimes it is necessary to replace Flemoklav Solutab with an analogue.

About the drug

The complex action drug belongs to the group of antibacterial drugs. Flemoklav Solutab is a potent antibiotic containing penicillin.

The active ingredients are amoxicillin trihydrate together with the addition of clavulanic acid. The drug is sold in the form of tablets (dispersible). Flemoklav Solutab 875 mg, 500 mg, as well as 125 mg are produced.

The indication for taking the medicine is an infectious lesion:

• bronchi and lungs;
• urinary organs;
• otolaryngological tissues;
• genital area;
• skin and soft tissues.

The drug is also prescribed for osteomyelitis, when an infection occurs after surgery and in order to prevent the listed pathologies.

Contraindications to the prescription of the medication:

• kidney disease;
• liver failure;
• mononucleosis;
• lymph leukemia;
• children less than 12 years old;
• body weight less than 40 kg;
• intolerance to any components of the composition.

Tablets can cause a number of side effects (you can read the list in the instructions), therefore, during pregnancy, it is not recommended to take it in the first trimester, and from the middle of the gestation period, drug treatment can be carried out only under the supervision of the attending physician.

The price of a medicine depends on its dosage. The minimum cost is 300 rubles. The medication is on the list of prescription drugs.

Analogs

In the event that a Flemoklav replacement is required, a specialist decides on a suitable analogue. All drugs in this category belong to the prescription group, therefore, it is impossible to purchase Flemoklav Solutab analogues without a doctor's prescription in an official pharmacy.

Given the effectiveness of the original product, the reason for the search for a substitute is most often its cost, or side effects... If there are contraindications, it is recommended to select an analogue of Flemoklav Solutab, which has the same active substance.

Analogues are cheaper:

• Amoxicillin;
• Panclave;
• Flemoxin Solutab;
• Ecoclave;
• Augmentin;
• Amoxiclav.

Consult a specialist before using any medication.

Amoxiclav

The drug Amoxiclav has a combined effect on the body and is prescribed to eliminate infection, accompanied by inflammation.

Amoxiclav release form:

• suspension powder;
• oral tablets;
• powder for injection.

Amoxiclav was developed by a Slovenian company. The antibiotic contains a potent component of amoxicillin. To increase the effect of the drug, clavulanic acid is added to the composition.

• for the treatment of infectious diseases arising on the skin and soft tissues, as well as in the bones;
• at complex therapy diseases internal organs respiratory tract;
• to eliminate otolaryngological, odontogenic and gynecological infectious pathologies;
• with inflammatory processes that have arisen in the gastrointestinal tract and urinary tract.

An injectable form of the drug is prescribed to treat an infection developing in the area abdominal and genitals. Injection powder is also used for prophylaxis before surgery.

Flemoklav substitute is contraindicated for the following health problems:

• a tendency to allergies to the active substance of the composition or additional components;
• infectious form of mononucleosis;
• lymphocytic leukemia.

During therapy, the patient may experience side effect symptoms that affect many body systems. The instructions for use describe in detail all possible reactions of the body to the medication. If a negative reaction occurs, you should stop taking Flemoklav and choose a substitute with a different composition.

Amoxiclav is relatively inexpensive drug, the price of which differs depending on the form of the medicine.

Average cost:

• tablets - 200 rubles;
• suspension - 100 rubles;
• injection powder - 550 rubles.

Flemoxin Solutab

Inexpensive analogue Flemoklav Solutab 500 mg. - Flemoxin. The drug is used to prevent an infectious process in the body.

The active ingredient - amoxicillin and clavulanic acid, have an antibiotic effect, preventing the development of an inflammatory and infectious process in the tissues of internal organs, joints, muscles and on the skin.

Flemoxin Solutab is available only in tablet form. Dispersible tablets have three main dosage types: 125 mg, 250 mg and 500 mg. Flemoxin Solutab 1000 mg is also sold.

Indications for use include infections:

• urogenital area;
• respiratory system;
• digestive system;
• muscle tissue;
• surfaces of the skin.

The maximum price for Flemoxin Solutab 1000 mg is 470 rubles, and the minimum price is 238 rubles. (125 mg).

Augmentin

Flemoklav Substitute - Augmentin is designed to eliminate health problems during the development of infection and subsequent inflammation in the human body. Reviews of the medication indicate its high effectiveness.

The drug contains active substances - amoxicillin / clavulanic acid. Unlike the original, the product is produced not only in the form of tablets, but also in the form of a suspension powder.

Augmentin has similar indications, including infection with:

• musculoskeletal system;
• dermis surfaces;
• soft tissues;
• urinary system;
• respiratory organs;
• oral cavity;
• genital area.

List of contraindications:

• allergy to the composition;
• kidney / liver pathology.

Treatment of children and pregnant women is permissible only if the risk to life is exceeded. Suspension is recommended for children from three months, tablets over 12 years old. The duration of treatment is determined exclusively by the treating specialist.

The cost of Augmentin differs significantly depending on how much the active substance is contained - amoxicillin.

Augmentin 125 milligrams is cheaper than the original - from 140 rubles.

Amoxicillin

When choosing domestic analogues, it is recommended to pay attention to the original drug, which has a name identical to the active ingredient - Amoxicillin. Unlike other analogues, this drug does not contain clavulanic acid.

An inexpensive medication has a list of indications, including an infectious process in the tissues of organs / systems:

• gastrointestinal tract;
• eNT organs - area;
• genitourinary system;
• upper and lower respiratory tract.

The use of a domestic substitute for the original is not recommended when diagnosing:

• allergic diathesis;
• infectious mononucleosis;
• bronchial asthma;
• respiratory viral infections;
• intolerance to the body of the components of the medication

A cheap analogue of Amoxicillin has a minimum price of 28 rubles.

Ecoclave

One more is enough cheap substitute - Ecoclave. The medicine also applies to antibiotic medications penicillin series.

Ekoklav's activity is based on the action of the substance amoxicillin and clavulanic calcium, which are part of the drug in the form of active ingredients.

Ekoklav is produced by the manufacturer in a standard tablet form with an established dosage of 500 mg. and in the form of a suspension powder with a dose of 125 mg.

Experts prescribe Ekoklav for the treatment of pathologies that have arisen against the background of the activity of an infection sensitive to active ingredients in the respiratory organs, urinary and its excretory system, the genital area and otolaryngology. The same medicine is used to treat the skin, osteoarticular and soft tissues.

Before use, it is necessary to consult with a specialist and determine whether the patient has contraindications, which are indicated in the instructions.

Side effects, according to reviews, are rare and of low intensity.

The price for Ekoklav in powder is from 150 rubles, and for tablets - from 250 rubles.

Panclave

You can also replace the original with Panklav. The drug is produced by a Serbian company and has an average cost of 300 rubles per drug with a dosage of 875 mg. The medication does not belong to cheap counterparts, but its price is slightly lower than Flemoklav.

The drug, as well as all of the listed analogs, contains substances that prevent infectious processes (clavulanic acid and amoxicillin), in the genital and urinary organs, oral cavity, respiratory system, as well as in diseases of bone, articular and epidermal tissues.

Panklav is contraindicated in children under 12 years old, during the period of gestation of a fetus by a woman, during breastfeeding, with infectious mononucleosis and with intolerance to the composition.

Replace Flemoklav with similar medicines possible only with the permission of a doctor. All medicines are antibiotics, which should be taken strictly according to the instructions or instructions of a specialist.

Instructions for use Flemoklav Solutab describes the features of the use of this combined semi-synthetic antibiotic, based on two active substances - amoxicillin and clavulanic acid. The predecessor of Flemoklav was the original drug Augmentin, which first appeared on the pharmaceutical market in 1979. It was this remedy, which successfully combined a combination of two active substances, that gave impetus to the creation of an effective generic - the Flemoklav Solutab dispersible tablets.

Flemoklav Solutab - principle of action

Popular penicillin antibiotic with a beta-lactamase inhibitor, it exhibits a wide spectrum of antibacterial action due to the peculiarities of its composition. It is known that many bacteria quickly enough managed to adapt to the chemical formula of benzylpenicillins and learned to produce special enzymes that destroy the beta-lactam ring. As a result, the use of penicillins could no longer provide the desired therapeutic effect.

The modern antibiotic amoxicillin is more resistant to the destructive force of pathogenic bacteria, however, it also needs a protective component to show maximum effectiveness. Clavulanic acid became such protection, which in its structure is close to penicillin, but exhibits very little antimicrobial activity.

However, due to its structural similarity to the antibiotic molecule and the presence of a beta-lactam ring, clavulanic acid takes a “hit” by interacting with destructive bacterial enzymes. As a result, the antibiotic amoxicillin receives reliable protection, exhibits increased resistance and the ability to destroy wide range pathogens.

The principle of action of the drug is based on the introduction of an active substance into a microbial cell, followed by blocking the synthesis of a special compound (peptidoglycan), which is responsible for the construction of cell membranes. As a result of the deficiency of this compound, the growth and development of the microbial cell stops, and it dies. The bactericidal effect of Flemoklav Solutab extends to most strains of pathogenic microflora, including gram-positive and gram-negative anaerobic and aerobic microorganisms.

After oral administration, the active substances are rapidly absorbed, penetrate the placental barrier and can be excreted in breast milk. At the same time, the simultaneous administration of the drug with food does not affect the absorption of the active ingredients. The drug is excreted from the body by the kidneys, within 6 hours up to 80% of amoxicillin and up to 50% of clavulanic acid are removed.

Release form

Flemoklav Solutab is available in the form of large, oblong dispersible white tablets with small brown blotches. The main difference between the medication is that the active substances are enclosed in microspheres - special capsules that protect the antibiotic from the aggressive effects of gastric juice and digestive enzymes.

Due to this, their release occurs only in the upper section. small intestine and duodenum, that is, in that part of the digestive system, where the most complete and rapid absorption of the drug is possible. Due to this feature, the dispersible form of the drug is better tolerated and safer, eliminates irritation of the intestinal mucosa and provides the most gentle action.

Good to know

The term "dispersible tablet" means that the drug rapidly dissolves in a minimum volume of liquid, forming a suspension.

Before ingestion, it should be homogenized, that is, thoroughly stirred. Due to its pleasant apricot taste, the suspension does not cause disgust and, unlike most bitter antibiotics, it is much easier to take.

Flemoklav Solutab is produced in four main forms:

1. Flemoklav Solutab 125 mg (125 mg + 31.25 mg);
2. Flemoklav Solutab 250 mg (250 mg + 62.5 mg);
3. Flemoklav Solutab 500mg (500mg + 125mg);
4. Flemoklav Solutab 875 mg (875 + 125 mg) - this option is often called Flemoklav Solutab 1000 mg by the sum of the main components.

The first figure indicated in the dosage of the drug means the concentration of the antibiotic amoxicillin, the second indicates the dose of clavulanic acid. Accordingly, the lower the concentration of the main active ingredient, the lower the dose of the protective component that stops the destructive force of bacteria.

Antibiotic tablets, 4 pieces, are packed in blisters and placed in cardboard boxes, each of which contains 5 blisters. Flemoklav Solutab 1000mg tablets are sold in packs containing 2 blisters containing 7 antibiotic tablets.

Indications

Modern antibacterial drug it is used in the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to Flemoklav. It is prescribed under the following conditions:

• eNT infections - organs, upper and lower respiratory tract (otitis media, sinusitis, frontal sinusitis, tonsillitis, pharyngitis, acute and chronic bronchitis, pneumonia, lung abscess, pleural empyema);
• infectious processes in the pelvic organs and genitourinary system (urethritis, prostatitis, cystitis, pyelonephritis, salpingitis, endometritis, bacterial vaginitis, complications after abortion, postpartum sepsis, gonorrhea, syphilis);
• infections of soft tissues and skin (infected dermatoses, impetigo, erysipelas, phlegmon, abscesses, infected wounds);
• infections of the joints and bone tissue (osteomyelitis);
• postoperative infections (sepsis).

The drug is often prescribed for dental infections that cause the destruction of bone tissue (periodontitis) or maxillary sinusitis, which is associated with an infectious process in the tissues upper jaw... As a prophylaxis, an antibiotic is used in surgery to prevent postoperative bacterial complications.

Instructions for use

Dispersible tablets are taken orally, after dissolving in 1/3 cup of water and mixing the contents thoroughly, or by swallowing the tablet whole and drinking plenty of liquid. It is recommended to take the drug before meals, since the medicine taken on an empty stomach can provoke irritation of the mucous membrane of the digestive tract.

The dosage of the medication and the duration of the course of treatment are determined by the doctor, taking into account the severity inflammatory process, type of disease, general condition of the patient and other nuances. The standard dosages of the drug, according to the instructions, are as follows:

Adult patients and adolescents over 12 years of age are prescribed 1 tablet (500 mg) every 8 hours, in severe cases this dose is doubled.

Flemoglav for children is used in a lower dosage. The daily dose of the drug is calculated by the doctor taking into account the child's body weight. Usually for babies aged 3 months to 2 years, 1 tablet (125 mg) is prescribed. The frequency of admission is twice a day. From three to seven years, the dosage of the drug is the same, but the frequency of administration is increased to three times a day. For children from 7 to 12 years old, the dose of the drug is doubled, that is, they are given 1 tablet (250 mg) every 8 hours.

The duration of treatment depends on the severity of the disease; on average, the course of antibiotic therapy takes 10 to 14 days.

Contraindications

Flemoklav Solutab exhibits less toxicity in comparison with other antibacterial agents, however, there are a number of pathologies that preclude the use of this drug. The antibiotic is contraindicated in the following conditions:

• hypersensitivity to the components of the drug or individual intolerance to beta-lactam antibiotics of the penicillin or cephalosporin series;
• lymphocytic leukemia.

Flemoklav Solutab 1000mg tablets cannot be used in the treatment of children under 12 years of age and weighing less than 40kg. In addition, this form of the drug should not be prescribed for renal failureif the glomerular filtration rate is less than 30 ml / min.

With extreme caution and under the supervision of a physician, the drug is prescribed for severe hepatic and chronic renal failure, pathologies of the digestive system, including colitis, developed against the background of the use of penicillins.

Adverse Reactions

Like any antibiotic, Flemoklav Solutab is capable of causing adverse reactions on the part of various body systems. Most often, such manifestations are noted from the digestive system. Taking pills can provoke flatulence, abdominal pain, nausea, vomiting, diarrhea. Much less often there are symptoms of intestinal candidiasis, colitis (hemorrhagic, pseudomembranous) or staining of the upper layer of tooth enamel.

Not uncommon and allergic reactions, which are accompanied by a rash, hives, itching. With prolonged use, measles-like exanthema, drug fever, serum sickness, or bullous dermatitis may develop. The most severe manifestations - anaphylactic shock, laryngeal edema or Quincke's edema, appear in exceptional cases. At the first sign of an allergic reaction, the drug should be discontinued and seek medical help... The patient may need the introduction of adrenaline or prednisone and measures to restore respiratory functions.

The following are much less common side effects:

1. On the part of the cardiovascular and nervous system - vasculitis, dizziness, migraine, insomnia, increased anxiety, aggressiveness, hyperactivity, changes in consciousness.
2. On the part of the hematopoietic organs - thrombocytosis, hemolytic anemia, leukopenia, granulocytopenia, thrombocytopenia, increased bleeding. But these disorders quickly disappear after drug withdrawal.
3. On the part of the liver, there is an increase in the activity of liver enzymes, in rare cases - manifestations of cholestatic jaundice or hepatitis. Genitourinary system - itching, burning, vaginal discharge, symptoms of nephritis (interstitial).
4. In very rare cases, against the background of prolonged use of the drug or repeated courses of antibiotic therapy, bacterial or fungal superinfections develop.

Flemoklav Solutab during pregnancy

Despite the fact that the active substances easily penetrate the placental barrier, clinical researches did not reveal the teratogenic effect of the drug on the fetus and the appearance of congenital malformations in a newborn baby. However, in the first trimester of pregnancy, Flemoklav Solutab should be prescribed only after assessing the potential risk to the fetus. During this period, the drug is prescribed with caution, such a form as Flemoklav 1000mg tablets are prohibited for use. You can use only those forms of the drug in which the active substance is present in lower concentrations.

During breastfeeding, both active substances penetrate into breast milk in rather large volumes, but they do not harm the baby. Therefore, it is possible not to transfer the child to artificial mixtures during the treatment of the mother with this antibiotic. But if a newborn develops hypersensitivity reactions - diarrhea, candidiasis of the mucous membranes, breast-feeding will have to stop for a while.

The use of the drug in patients with severe liver dysfunctions requires special care. In this case, the dosage of the antibiotic is reduced and regular laboratory control and monitoring of the patient's condition are carried out.

Good to know

A balanced approach requires prescribing the drug in persons with severe forms of bronchial asthma or allergies, especially in cases where allergic reactions have occurred previously to the use of antibiotics from the group of penicillins or cephalosporins.

Flemoklav Solutab should not be administered simultaneously with disulfiram, aminoglycosides, laxatives, as this reduces the absorption of active substances. You should not combine taking an antibiotic with indirect coagulants, since this tactic increases the risk of bleeding.

Analogs

The structural analogs of Flemoklav Solutaba include the following drugs:

• Augmentin;
• Bactoclav;
• Lyclavus;
• Panclave;
• Taromentin;
• Fibell.

The decision to replace the antibiotic with similar means should be made only by the attending physician.

Price

The cost of the drug depends on the form of release and the concentration of active substances in the tablets. Average prices for Flemoklav Solutab in pharmacies:

• Tablets 125mg (20pcs) - from 290 rubles;
• Tablets 250 mg (20 pcs) - from 400 rubles;
• 500mg tablets (20pcs) - from 380 rubles;
• Tablets 875 mg (14 pcs) - from 370 rubles.

For children, one of the suspensions is well suited:

Price

Average online price *, 421 p. (tab 500mg + 125mg)

Where could I buy:

Instructions for use

Flemoklav Solutab is a broad spectrum antibiotic. It is used to treat children and adults, including can be used by women during the period breastfeeding.

Indications

The drug is intended for the treatment of infectious and inflammatory diseases caused by sensitive microorganisms:

• diseases of the upper respiratory tract and ENT organs (sinusitis, tonsillitis, pharyngitis, otitis media, etc.);
• infections of the skin and soft tissues;
• lower respiratory tract diseases (COPD, community-acquired pneumonia, exacerbations chronic bronchitis and etc.);
• infections of the urinary system (pyelonephritis, cystitis, etc.).

Tablets 875 mg + 125 mg are also prescribed in obstetrics, gynecology and for the treatment of infections of bones and joints (osteomyelitis, etc.).

Method of administration and dosage

The medicine is taken orally before meals - this helps prevent the appearance of dyspeptic disorders. The tablets are swallowed whole without chewing and drinking water. Another option is to dissolve the tablet in 30 ml of water, stir and drink. The maximum duration of taking the drug is 14 days, but on the recommendation of a doctor, the course of treatment can be extended.

Adults, children from 12 years old and younger children weighing 40 kg or more take 500 mg + 125 mg 3 times a day or 875 mg + 125 mg 2 times a day.

The tablets are drunk at regular intervals. Doses are sometimes doubled if the patient has a severe, chronic, or recurrent infection.

Children under 12 years of age weighing less than 40 kg take the drug in smaller doses: 125 mg + 31.25 mg; 250 mg + 62.5 mg or 500 mg + 125 mg.

Children aged 2-7 years with a weight of 13-25 kg are prescribed 125 mg + 31.25 mg 3 times a day, children 7-12 years old weighing up to 37 kg - 250 mg + 62.5 mg. If the infection is severe, the daily dose can be doubled.

Renal failure

Due to the delayed excretion of amoxicillin and clavulanic acid by the kidneys, the drug at a dosage of 875 mg + 125 mg is prescribed provided that glomerular filtration is at a rate higher than 30 ml / min.

The total dose of the drug, expressed in the amount of amoxicillin, should not be higher than the values \u200b\u200bindicated in the table:

Liver pathology

The drug is prescribed with caution. During the period of treatment, it is necessary to constantly monitor liver function.

Contraindications

Absolute contraindications:

• intolerance to the components of the drug;
• intolerance to other beta-lactam antibiotics (penicillins and cephalosporins);
• lymphocytic leukemia;
• infectious mononucleosis;
• previous jaundice or liver dysfunction while taking amoxicillin and clavulanic acid.

Tablets 875 mg + 125 mg should also not be taken by children under 12 years of age weighing less than 40 kg and patients with renal insufficiency in whom the glomerular filtration rate is 30 ml / min. and less.

Relative contraindications:

• severe kidney failure;
• diseases of the gastrointestinal tract (including previous colitis caused by treatment with penicillins);
• chronic insufficiency kidneys.

Pregnancy and lactation

Treatment with the drug during lactation is allowed. If the baby develops diarrhea, sensitization, or mucosal candidiasis, the mother must stop breastfeeding until treatment ends.

Overdose

If these symptoms appear, the victim should take activated charcoal. He is also shown symptomatic treatment.

Side effects

Tablets 125 mg + 31.25 mg; 250 mg + 62.5 mg; 500 mg + 125 mg can provoke a number of negative reactions:

• urticaria and exanthema;
• diarrhea;
• nausea with vomiting;
• violations in the liver;
• vasculitis;
• changes in the composition of the blood;
• cholestatic jaundice;
• hepatitis;
• interstitial nephritis;
• development of superinfection;
• anaphylactic shock (isolated cases).

When taking 875 mg + 125 mg tablets, the following are possible:

• allergic reactions;
• development of superinfection;
• thrombocytosis and hemolytic anemia;
• headache and dizziness;
• convulsions;
• abdominal pain;
• nausea with vomiting;
• diarrhea;
• flatulence;
• a slight increase in the activity of liver enzymes;
• cholestatic jaundice;
• hepatitis.

Composition

The active substances are amoxicillin (125; 250; 500 or 875 mg) and clavulanic acid (31.25; 62.5 or 125 mg).

Auxiliary components: crospovidone, vanillin, MCC, apricot flavor, magnesium stearate, saccharin.

Pharmacology and pharmacokinetics

Flemoklav Solutab is a broad spectrum antibiotic. It inhibits the synthesis of the bacterial wall.

The drug is active against gram-negative and gram-positive microorganisms, including strains that produce beta-lactamases.

Clavulanic acid has a high affinity for penicillins.

Therefore, it forms a stable complex with the enzyme and prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases. As a result, the spectrum of its action expands.

Shelf life

3 years (2 years for 875 mg + 125 mg tablets).

Name:

Flemoclav Solutab

Pharmachologic effect:

Flemoklav Solutab is a broad-spectrum antibiotic that is active against gram-positive and gram-negative microorganisms, including bacteria that produce beta-lactamases. Amoxicillin in combination with clavulanic acid has a significantly wider spectrum of action than monotherapy.

Amoxicillin is a beta-lactam antibiotic of the penicillin group. Amoxicillin violates the integrity of the bacterial cell membrane, as a result of which the death of the microorganism occurs. Amoxicillin is inactivated by beta-lactamases, therefore, when monotherapy is inactive against strains that produce beta-lactamases.

Clavulanic acid - has a slight antimicrobial effect. Clavulanic acid inactivates the beta-lactamases of staphylococci and gram-negative bacteria.

Flemoklav Solutab is effective against Streptococcus faecalis, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis, Moraxella catarrhalis, Haemophilus influenzae, Proteus mirabilis, as well as Bacteroides fragilis. ...

Absolute bioavailability of amoxicillin at oral administration depends on the dose and is about 72-94%, clavulanic acid - about 60%. The peak plasma concentration of amoxicillin and clavulanic acid is reached within 1-2 hours. Food intake does not affect the rate of absorption and bioavailability of Flemoklav Solutab.

Amoxicillin is excreted mainly by the kidneys, the half-life is about 1-1.5 hours, in patients with renal dysfunction, the half-life of amoxicillin increases. Amoxicillin crosses the blood-placental barrier and is determined in breast milk.

Indications for use:

Flemoklav Solutab is intended for the treatment of patients with infectious diseases of various localization and severity, which are caused by microflora sensitive to the combination of amoxicillin and clavulanic acid.

In particular, Flemoklav Solutab is prescribed in otolaryngological practice and for infectious diseases of the skin, soft tissues, respiratory tract and urinary tract organs.

Flemoklav Solutab can also be prescribed for sepsis, osteomyelitis, peritonitis and postoperative infections.

Application method:

Flemoklav Solutab is intended for oral administration. Dispersed tablets should be swallowed whole or chewed with a little drinking water. In addition, tablets can be taken by first dissolving in half a glass of drinking water. To reduce the risk of developing undesirable effects from the digestive tract, the drug should be taken immediately before meals. To achieve maximum therapeutic effect tablets are recommended to be taken at regular intervals. The drug therapy should be continued for at least 3 days after the disappearance of the symptoms of the disease. For infections caused by hemolytic streptococcus, the duration of therapy should be at least 10 days.

The duration of administration and the dose of Flemoklav is determined by the attending physician.

Adults and adolescents weighing more than 40 kg, as a rule, are prescribed 500 mg of the drug three times a day. In chronic, recurrent infections, as well as severe forms of diseases, the dose can be increased to 875-1000 mg of amoxicillin three times a day.

Children weighing 13 to 37 kg are usually prescribed 20-30 mg / kg of body weight per day. The daily dose should be divided into three doses. For chronic, recurrent infections, as well as severe forms of diseases, the dose can be increased to 60 mg / kg of body weight per day.

Elderly patients with normal renal function do not require dose adjustment of Flemoklav.

For patients with renal dysfunction, the dose of amoxicillin and clavulanic acid is calculated depending on creatinine clearance.

Adults with a creatinine clearance of 10 to 30 ml / min, as a rule, are prescribed 500 mg of amoxicillin twice a day.

Adults with creatinine clearance less than 10 ml / min, as a rule, are prescribed 500 mg of amoxicillin per day.

Children with creatinine clearance of 10 to 30 ml / min, as a rule, are prescribed amoxicillin at a dose of 15 mg / kg body weight twice a day.

Children with creatinine clearance less than 10 ml / min are usually prescribed amoxicillin at a dose of 15 mg / kg of body weight per day.

Adverse events:

During the period of therapy with amoxicillin and clavulanic acid, the following undesirable phenomena may develop:

From the hepatobiliary system and the gastrointestinal tract: pain and discomfort in the stomach, nausea, flatulence, vomiting, diarrhea, dyspepsia, discoloration of tooth enamel, dryness of the oral mucosa, changes in taste and increased levels of liver enzymes. In some cases, the development of pseudomembranous colitis, hemorrhagic colitis, intestinal candidiasis, hepatitis (including cholestasis) and severe liver dysfunction was noted.

From the side of blood vessels, heart and hematopoietic system: hemolytic anemia, thrombocytosis, granulocytopenia, leukopenia, thrombocytopenia, pancytopenia, anemia and myelosuppression. In addition, there was an increase in bleeding time and the development of vasculitis.

From the side of the central nervous system: convulsions, headache, dizziness, unreasonable anxiety, increased fatigue, aggression.

Allergic reactions: urticaria, exanthema, itchy skin, Stevens-Johnson syndrome, exudative erythema multiforme, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, and Quincke's edema. In isolated cases, the development of anaphylactic shock (including fatal) was noted in this case, adrenaline, parenteral glucocorticosteroids are prescribed and therapy for respiratory failure is carried out.

Others: superinfection, vaginal candidiasis, vaginitis, interstitial nephritis, crystalluria.

Contraindications:

Flemoklav is not prescribed for patients with individual intolerance to amoxicillin, clavulanic acid and beta-lactam antibiotics (including penicillins and cephalosporins).

Flemoklav should not be used in patients who have developed liver dysfunctions during previous use of clavulanic acid or amoxicillin, as well as in patients with diseases of the digestive tract, which are accompanied by chronic diarrhea and vomiting.

Flemoklav is contraindicated in infectious mononucleosis and lymphocytic leukemia.

Special care should be taken when prescribing Flemoclav to patients with a tendency to develop anaphylactoid reactions, bronchial asthma and impaired liver and kidney function.

Patients who drive a car or operate potentially unsafe machinery should be especially careful during the period of therapy with Flemoklav.

During pregnancy:

Amoxicillin and clavulanic acid do not adversely affect fetal development. The combination of amoxicillin and clavulanic acid may be prescribed during pregnancy after a careful assessment of the risks and benefits. In the first trimester of pregnancy, safer alternatives are recommended.

If it is impossible to avoid taking Flemoklav during lactation, it is recommended to resolve the issue of temporarily interrupting breastfeeding.

Interaction with other medicinal products:

During the period of therapy with Flemoklav, it is not recommended to prescribe chemotherapeutic drugs and antibiotics that have a bacteriostatic effect (with combined use, the effectiveness of amoxicillin decreases).

The effectiveness of amoxicillin can increase when combined with cephalosporins, rifampicin, vancomycin and cycloserine.

The combined use of amoxicillin with disulfiram is prohibited.

There is an increase in the level of plasma concentrations of amoxicillin when combined with probenecid, oxyphenbutazone, butadione, indomethacin, sulfinpyrazone and acetylsalicylic acid.

The risk of developing skin allergic reactions with the combined use of the drug Flemoklav with allopurinol.

Amoxicillin reduces plasma concentrations of sulfasalazine and increases plasma concentrations and toxicity of methotrexate when used in combination.

Flemoklav, when used simultaneously, can increase the absorption of digoxin.

The risk of bleeding increases with the combined use of coumarin anticoagulants and Flemoklav.

The combination of amoxicillin and clavulanic acid can lead to a decrease in the effectiveness of estrogen-containing oral contraceptives and a change in some laboratory results.

Ascorbic acid increases the absorption of amoxicillin, and laxatives, glucosamine, antacids and aminoglycosides reduce intestinal absorption of amoxicillin.

Overdose:

When using overestimated doses of amoxicillin and clavulanic acid in patients, the risk of developing and the severity of undesirable effects increases.

In case of an overdose of Flemoklav, it is possible to develop disorders of the digestive tract, violations of the water-electrolyte balance and seizures.

In case of severe intoxication with amoxicillin, patients report disturbances of consciousness, muscle cramps, hemolytic reactions, acidosis and renal failure, as well as shock and crystalluria.

There is no specific antidote. When taking high doses of Flemoklav, gastric lavage, enterosorbent drugs and osmotic laxatives are indicated. In case of overdose, control water and electrolyte balance and blood pH.

When seizures develop, diazepam is prescribed. In severe renal failure, hemodialysis should be performed.

The development of a state of shock requires immediate resuscitation.

In order to reduce the plasma concentration of amoxicillin, forced diuresis is also indicated.

Release form of the drug:

Dispersed tablets containing 125, 250 or 50 mg of amoxicillin, packaged in 5 pieces in blisters, in a cardboard box 4 blisters.

Dispersed tablets containing 875 mg of amoxicillin, packaged in 5 or 7 pieces in blisters, in a cardboard box 2 blisters.

Storage conditions:

Flemoklav is stored for no more than 3 years from the date of manufacture in rooms at a temperature not exceeding 25 ° C.

The appearance of marbling and small brown dots on the surface of the tablets during storage is allowed.

Synonyms:

Amoxiclav, Augmentin, Medoklav.

Composition:

1 tablet of the drug Flemoklav 125 + 31.25 contains:

Amoxicillin - 125 mg

Clavulanic acid - 31.25 mg,

1 tablet of the drug Flemoklav 250 + 62.5 contains:

Amoxicillin - 250 mg

Clavulanic acid - 62.5 mg,

Additional substances including vanillin and saccharin.

1 tablet of the drug Flemoklav 500 + 125 contains:

Amoxicillin - 500 mg

Additional substances including vanillin and saccharin.

1 tablet of Flemoklav 875 + 125 contains:

Amoxicillin - 875 mg,

Clavulanic acid - 125 mg,

Additional substances including vanillin and saccharin.

Drugs with a similar action:

Medoclav Bicillin-3 (Bicillinum-III) Amoxil Clonacom-X Clonacom-P

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The page provides instructions for use Flemoklava solutab... It is available in various dosage forms the drug (tablets 125 mg, 250 mg, 500 mg, 875 mg and 1000 mg dispersible), and also has a number of analogues. This annotation has been checked by specialists. Leave your feedback on the use of Flemoklav Solutab, which will help other site visitors. The drug is used for various diseases (tonsillitis, bronchitis, sinusitis, otitis media and others infectious diseases). The tool has a number of side effects and interactions with other substances. Doses of the drug differ for adults and children. There are restrictions on the use of the drug during pregnancy and lactation. Treatment with Flemoklav Solutab can only be prescribed by a qualified doctor. The duration of therapy can vary and depends on the specific disease.

Instructions for use and dosage

Adults and children over 12 years old and children under 12 years old weighing more than 40 kg Flemoklav Solutab at a dose of 875 mg / 125 mg is prescribed 2 times a day (every 12 hours).

Children under 12 years old with a body weight of less than 40 kg are prescribed Flemoklav Solutab in lower dosages.

For adults and children weighing more than 40 kg, the drug is prescribed 500 mg / 125 mg 3 times a day. For severe, chronic, recurrent infections, this dose can be doubled.

The daily dose for children is usually 20-30 mg of amoxicillin and 5-7.5 mg of clavulanic acid per kg of body weight. Possible dosing regimen for children, depending on the age and body weight of the child:

• age from 3 months to 2 years - body weight from 5 to 12 kg - daily dose tablets 125 mg / 31.25 mg 2 times a day;
• age from 2 to 7 years - body weight from 13 to 25 kg - daily dose of a tablet 125 mg / 31.25 mg 3 times a day;
• age from 7 to 12 years - body weight from 25 to 37 kg - daily dose of a tablet 250 mg / 62.5 mg 3 times a day.

When severe infections these doses can be doubled (the maximum daily dose is 60 mg of amoxicillin and 15 mg of clavulanic acid per kg of body weight).

The duration of treatment depends on the severity of the infection and should not exceed 14 days unnecessarily.

To prevent the appearance of side effects from the digestive system, it is recommended to take the drug at the beginning of a meal. The tablet is swallowed whole with a glass of water, or dissolved in half a glass of water (at least 30 ml), stirring thoroughly before use (a suspension is obtained that is convenient for children to take).

Forms of issue

Dispersible tablets 125 mg, 250 mg, 500 mg, 625 mg, 875 mg and 1000 mg.

There are no other forms of release, be it syrup, injections in ampoules or capsules.

Composition

Amoxicillin trihydrate (Amoxicillin) + Potassium clavulanate (Clavulanic acid) + excipients.

Flemoklav solutab - broad-spectrum antibiotic; combination drug amoxicillin and clavulanic acid - a beta-lactamase inhibitor. Active against gram-positive and gram-negative microorganisms (including strains producing beta-lactamases).

Amoxicillin acts bactericidal, inhibits the synthesis of peptidoglycan of the bacterial cell wall. Clavulanic acid inhibits beta-lactamase types 2, 3, 4 and 5. Inactive against type 1 beta-lactamases produced by Enterobacter spp., Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp. Clavulanic acid has a high tropism for penicillinases, due to which it forms a stable complex with the enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamases and expands its spectrum of action.

Flemoklav Solutab is active against aerobic and anaerobic gram-positive bacteria, aerobic and anaerobic gram-negative bacteria.

Pharmacokinetics

Amoxicillin

After oral administration, it is rapidly absorbed from the gastrointestinal tract. Oral absorption of amoxicillin is 90-94%. Concomitant food intake does not affect absorption. Amoxicillin crosses the placental barrier and is excreted in breast milk in small amounts. Approximately 60-80% of amoxicillin is excreted through the kidneys within the first 6 hours after taking the drug.

Clavulanic acid

After oral administration, it is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability is approximately 60%. Concomitant food intake does not affect absorption. Serum protein binding is 22%. Clavulanic acid crosses the placental barrier. There are no reliable data on excretion in breast milk. Clavulanic acid is extensively metabolized by hydrolysis and subsequent decarboxylation. Approximately 30-50% of clavulanic acid is excreted through the kidneys during the first 6 hours after taking the drug.

Indications

• bacterial infections caused by sensitive pathogens: lower respiratory tract infections (bronchitis (acute and chronic exacerbation), pneumonia, pleural empyema, lung abscess);
• eNT infections (sinusitis, tonsillitis, tonsillitis, otitis media);
• infections of the genitourinary system and pelvic organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingo-oophoritis, tubo-ovarian abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvioperitonitis, chancroid soft);
• infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses, abscess, phlegmon, wound infection);
• osteomyelitis;
• postoperative infections;
• prevention of infections in surgery.

Contraindications

• liver dysfunction (including jaundice) with a history of amoxicillin / clavulanic acid;
• infectious mononucleosis;
• lymphocytic leukemia;
• renal failure (glomerular filtration less than 30 ml / min) - for dispersible tablets 875 mg / 125 mg;
• children under 12 years of age weighing less than 40 kg (for dispersible tablets 875 mg / 125 mg);
• hypersensitivity to amoxicillin, clavulanic acid and other components of the drug;
• hypersensitivity to other beta-lactam antibiotics (penicillins and cephalosporins).

special instructions

When taking Flemoklav Solutab, there is a possibility of cross-resistance and hypersensitivity with other penicillins or cephalosporins.

If anaphylactic reactions develop, the drug should be stopped immediately and appropriate therapy should be carried out: for the treatment of anaphylactic shock, urgent administration of epinephrine (adrenaline), glucocorticosteroids (GCS) and elimination of respiratory failure may be required.

Superinfection (eg, candidiasis) may develop, especially in patients with chronic diseases and / or functional impairment immune system... In the event of superinfection, the drug should be discontinued and / or the antibiotic therapy should be changed accordingly.

For patients with severe gastrointestinal disorders accompanied by vomiting and / or diarrhea, the appointment of Flemoklav Solutab is inappropriate until the above symptoms are eliminated, because possible impairment of absorption of the drug from the gastrointestinal tract.

The appearance of severe and persistent diarrhea may be associated with the development of pseudomembranous colitis, in which case the drug is discontinued and prescribed necessary treatment... In case of development of hemorrhagic colitis, immediate withdrawal of the drug and corrective therapy are also necessary. The use of drugs that weaken intestinal motility in these cases is contraindicated.

In case of impaired liver function, the drug should be prescribed with caution and under constant medical supervision. Do not use the drug for more than 14 days without assessing liver function.

In a single study, prophylactic use of amoxicillin / clavulanate in women with premature rupture of membranes increased the risk of necrotizing enterocolitis in newborns.

While taking the drug, there may be an increase in prothrombin time. Therefore, Flemoklav Solutab should be prescribed with caution to patients receiving anticoagulant therapy (it is necessary to monitor blood clotting indicators).

In connection with high concentration amoxicillin in the urine, it can deposit on the walls of the urinary catheter, so such patients need periodic catheter changes. Forced diuresis accelerates the excretion of amoxicillin and reduces its concentration in plasma.

During the period of application of Flemoklav Solutab, non-enzymatic methods for determining glucose in urine, as well as a test for urobilinogen, can give false positive results.

During the course of treatment, it is necessary to control the functions of the hematopoietic organs, liver and kidneys.

In case of seizures during therapy, the drug is canceled.

It should be borne in mind that 1 dispersible tablet 875 mg / 125 mg contains 25 mg of potassium.

Side effect

• thrombocytosis, hemolytic anemia, leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia;
• increased prothrombin time and bleeding time;
• dizziness;
• headache;
• convulsions;
• anxiety;
• anxiety;
• insomnia;
• violation of consciousness;
• aggressive behavior;
• vasculitis;
• abdominal pain;
• nausea, vomiting;
• flatulence;
• diarrhea;
• pseudomembranous colitis (in case of severe and persistent diarrhea while taking the drug or within 5 weeks after the end of therapy);
• intestinal candidiasis;
• hemorrhagic colitis;
• cholestatic jaundice;
• itching, burning, and vaginal discharge;
• interstitial nephritis;
• skin rash and itching;
• bark-like exanthema;
• hives;
• bullous or exfoliative dermatitis (erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis);
• anaphylactic shock;
• drug fever;
• eosinophilia;
• angioedema (Quincke's edema);
• laryngeal edema;
• serum sickness;
• hemolytic anemia;
• allergic vasculitis;
• bacterial or fungal superinfections (with prolonged therapy or repeated courses of therapy).

Drug interactions

With simultaneous use with some bacteriostatic drugs (for example, chloramphenicol, sulfonamides), antagonism with amoxicillin / clavulanic acid was noted.

Flemoklav Solutab should not be administered concomitantly with disulfiram.

The simultaneous administration of drugs that inhibit the renal excretion of amoxicillin (probenecid, phenylbutazone, oxyphenbutazone and, to a lesser extent, acetylsalicylic acid, indomethacin and sulfinpyrazone), increases the concentration and a longer stay of amoxicillin in the blood plasma and bile. The excretion of clavulanic acid is not impaired.

With simultaneous use with Flemoklav Solutab antacids, glucosamine, laxatives, aminoglycosides slow down and reduce the absorption of amoxicillin, ascorbic acid increases the absorption of amoxicillin.

The simultaneous use of Flemoklav Solutab with allopurinol may increase the risk of developing skin rashes.

Ethanol (alcohol) reduces the rate of absorption of Amoxicillin in the gastrointestinal tract.

Aminopenicillins can reduce serum sulfasalazine concentrations.

Amoxicillin reduces the renal clearance of methotrexate, which may lead to an increased risk of it toxic effect... When taken simultaneously with amoxicillin, it is necessary to monitor the concentration of methotrexate in the blood serum.

The simultaneous use of amoxicillin / clavulanic acid and digoxin may increase the absorption of digoxin.

With the simultaneous use of Flemoklav Solutab and indirect anticoagulants, an increase in the risk of bleeding is possible.

In rare cases, while taking amoxicillin, there was a decrease in the effectiveness of oral contraceptives, so the patient should be advised to use non-hormonal methods of contraception.

Analogs medicinal product Flemoklav solutab

Structural analogues for the active substance:

• Amovikomb;
• Amoxiclav;
• Amoxiclav Kviktab;
• Amoxicillin + Pfizer Clavulanic Acid;
• Arlet;
• Augmentin;
• Bactoclav;
• Verclave;
• Klamosar;
• Lyclavus;
• Medoclav;
• Panclave;
• Ranklove;
• Rapiklav;
• Taromentin;
• Fibell;
• Ecoclave.

Application during pregnancy and lactation

When using Flemoklav Solutab during pregnancy, it was not noted negative influence on a fetus or newborn. The use of the drug in the 2nd and 3rd trimester of pregnancy is possible after a medical risk / benefit assessment. In the 1st trimester of pregnancy, the use of Flemoklav Solutab should be avoided (only for dispersible tablets 875 mg / 125 mg). Dispersible tablets 125 mg / 31.25 mg, 250 mg / 62.5 mg, 500 mg / 125 mg in the 1st trimester of pregnancy should be administered with caution.

Amoxicillin and clavulanic acid penetrate the blood-placental barrier and are excreted in breast milk. It is possible to use the drug during breastfeeding.

If the child develops sensitization, diarrhea or candidiasis of the mucous membranes, breastfeeding should be discontinued.