Cetrin ( Cetrine) - a modern antihistamine drug that has antiallergic, antiexudative, antipruritic effect. The drug is manufactured by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy network, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in a blister pack and in the form of a syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

The active substance of Cetrin is cetirizine (a metabolite of hydroxyzine), which is a blocker of H1-histamine receptors, competitive antagonist histamine. Ceterizine effectively relieves the manifestations of allergies, and also prevents its development. Possessing antiexudative and antipruritic action, Ceterizin helps to limit the release of inflammatory mediators, prevents the release of histamine, serotonin, bradykinin by mast cells, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, relieves smooth muscle spasm. In the treatment of mild bronchial asthma, Cetrin reduces histamine-induced bronchospasm.

When taking therapeutic doses of Tsetrin, there is no sedative effect. The therapeutic effect after taking 10 mg of the drug is noted after 30-60 minutes and lasts 1 day. Addiction to the antihistamine effect does not develop at therapeutic dosages. After stopping the intake of Tsetrin, the effect lasts for 3 days.

The active ingredients are a part of Tsetrin:

• Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
• Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, sorbitol solution 70%, purified water, flavor.

Ceterizin is absorbed quickly enough after oral administration, the maximum plasma concentration is observed after 60 minutes. The drug is recommended to be taken before meals, as the digestion processes slow down its absorption.

A small amount of Cetirizine is metabolized in the liver. The drug does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body mainly by the kidneys.

In case of impaired renal excretory function, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Tsetrin are allergic diseases:

• Seasonal and perennial rhinitis, conjunctivitis;
• Drug and food allergies;
• Dermatoses of allergic genesis (in complex treatment);
• Chronic recurrent urticaria;
• Quincke's edema;
• Atopic dermatitis (in combination treatment).

Contraindications to the appointment and side effects

When treating with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depressive conditions. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the appointment of Tsetrin are:

• Intolerance to the components of the drug;
• Pregnancy and lactation;
• For children under 6 years old, Tsetrin is prescribed in the form of a syrup.

Ways of using Tsetrin

Tsetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years old are prescribed 1 tab. (10 milligrams) once daily.

For children over 6 years old, give half a tablet (5 milligrams) twice a day.

Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, they give ½ tea. spoon once a day.

With hepatic and renal failure, adults are prescribed half a tablet (5 milligrams) once a day.

The course duration of treatment is 1-4 weeks. In the treatment of chronic allergic diseases, the duration of therapy can be increased up to 6 months.Read the instructions for use before taking Cetrin.

Can Cetrin be prescribed during pregnancy and lactation?

The active substance Cetirizine crosses the placental barrier, is found in breast milk, having a negative effect on the condition of the fetus and newborn, therefore, the drug is contraindicated in pregnancy and lactating breast milk.

Interaction with other medications

Tsetrin is used with caution in conjunction with sedatives. With simultaneous administration with theophylline, there may be an accumulation of Cetirizine and an overdose phenomenon.

An overdose of the drug is possible if the recommended dose is accidentally exceeded, accompanied by drowsiness, increased heart rate, hand tremors, pruritus, urinary retention. It is recommended to cancel the drug, gastric lavage, as well as the intake of enterosorbents: Polysorb, Enterosgel, Enterosorb, Lactofiltrum, Activated carbon. There is no specific antidote.

Are there analogues of Cetrin?

Similar pharmacological properties have antihistamines: Zyrtec, Zodak, which include Cetirizine, as well as Loratadin, Klarotadin, Claritin, the main active ingredient of which is Loratadin, Erius (Desloratadin), Ketotifen. The drugs of the first group belong to the latest generation of antiallergic drugs, their price in pharmacies is slightly higher. Loratadin Verte has the lowest cost among analogues of Cetrin. The effectiveness of antihistamines last generation slightly higher.

How to store the medicine correctly?

Store cetrin in a dark place. Storage temperature 15 to 25 degrees Celsius. The shelf life of the medicine is two years.

The price of a medicine in a pharmacy network

Cetrin can be purchased at most drug stores. The average cost of the drug is:

• Cetrin syrup, 60 ml (1 mg / ml) - 95 - 105 rubles;
• Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.

Against the background of increased production of histamine, lacrimation is observed, natural breathing is disrupted, there is a feeling of itching and burning. The development of side effects is highly undesirable during gestation.

The therapeutic regimen of pregnant women includes sparing antihistamines of 3 generations, among which "Cetrin" is widespread. The active components are devoid of a cardiotoxic sedative effect, have high selectivity, and are not addictive. Is it possible to drink "Cetrin" during pregnancy, and in what doses / course, so as not to harm the health of the baby and mother?

The feasibility of taking "Tsetrina" at different periods of gestation

The drug is presented on the pharmacological market syrup and tablets coated with a multicomponent dissolving shell. Regardless of the form of release, the main composition forms a competitive histamine antagonist - cetirizine.

H1 histamine receptor blocker exhibits antipruritic, antiexudative and antiallergic activity... The therapeutic effect is enhanced by the presence of excipients in the composition: corn starch, lactose, povidone KZO.

"Cetrin" relieves symptoms of an allergic reaction, prevents the development of pathological changes in the influence of antigens. The action of the drug is aimed at inhibiting the synthesis of stimuli, reducing the cells of the leukocyte lineage, increasing the throughput of capillaries.

The components are quickly absorbed in the gastrointestinal tract, the medical effect occurs within an hour after ingestion, lasts up to 24 hours.

The productivity and safety of Cetrin is explained by the fact that it does not affect serotonin and cholinergic nerve endings. Research that would prove possible harm the health of the mother and the unborn child was not carried out on patients.

For reference! The constituent components can be excreted in milk during breastfeeding, therefore antihistamines are prohibited during lactation.

According to the instructions for the use of "Cetrin" during pregnancy, the drug is included in the therapeutic regimen at all stages of gestation, when the threat to the health of the mother and child exceeds the potential harm from taking the medication.

In order to prevent the risk of side effects it is necessary to take an allergic drug according to the recommendations of a doctor and under medical supervision.

The minimum toxic effect on the fetus is exerted by the use of "Cetrin" in the 2nd trimester. Bookmark internal organs completed, the placenta is formed, the embryo is protected from the effects of the constituents of the drug.

Contraindications

Due to the fact that the drug is excreted from the body mainly by the kidneys, it is prescribed with caution to patients with a history of renal and hepatic insufficiency.

For reference! In the therapeutic regimen for the elderly, "Cetrin" is included in a reduced dosage.

In pediatrics, the pharmaceutical product is approved from the age of six, mainly in the form of a syrup. With hypersensitivity of the body to individual components or overdose, the development of the following disorders is noted:

• headaches;
• signs of intoxication;
• depressive state;
• dizziness;
• increased blood pressure, tachycardia;
• tremor of the upper limbs;
• sensations of dry mouth.

"Cetrin" during early pregnancy

After fertilization of the egg, the embryo formation period begins, which covers the first 13 weeks. At this time, the laying of organs and systems takes place. The multiplying cells of the fetus are sensitive to external factors.

Use of pharmacological products in early gestation fraught with serious pathological disorders.

A weak placental barrier does not create hope of protection against the penetration of medicinal components, as a result - the development of fetal hypoxia, spontaneous abortion.

The ability of an antihistamine to affect the fetus is predetermined by physiological features the patient and the condition of the placenta, course and dosage.

Contraindications "Tsetrina" during pregnancy in the 1st trimester indicate an increase in the likelihood of side effects, but this does not mean that pathological changes are characteristic for each clinical case.

Therefore, in order to prevent the risk of defectiveness of the unborn child, it is advisable to show increased concern for your health and the baby in order to eliminate the need for drug treatment.

Method of administration and dosage

Widespread in ENT practice is the tablet form of the release of an antiallergic product. 1 tablet contains 10 mg. cetirizine dihydrochloride. This is a one-time norm for adults. With reduced renal function, the dose is halved - half a tablet (5 mg). The daily rate is limited to two steps.

For reference! In chronic renal failure, "Cetrin" is prescribed at 5 mg. in one day.

Duration of the drug regimen determines the form of the lesion, the etiology of the pathogen, the general course clinical picture... For prophylaxis, the course of application varies from 2 weeks to a month.

For therapeutic purposes, it is prescribed in a cycle from 14 days to six months. Medicinal effect persists for the next 3 days after discontinuation of the drug.

The digestion process does not slow down the absorption period active ingredients, therefore, it is allowed to take the tablets before or after meals with plenty of water.

The scheme for taking the liquid form does not differ from the previous variation. From the age of twelve, 10 ml is prescribed. syrup twice a day, provided that there are no pathological disorders of the kidneys.

Conclusion

Before using "Cetrin" it is recommended to study the annotation in order to prevent the development of side effects. The 3rd generation antihistamine exhibits a high therapeutic effect in a gentle form with conjunctivitis, hay fever, dermatosis, in complex therapy at bronchial asthma.

Minimal development risks side effects from the use of the drug are observed in the 2nd trimester of pregnancy. Therefore, early and late periods are contraindications for the appointment.

Cetrin is medication antihistamine action of 3 generations. It is used to combat allergic reactions in patients of various ages. At the moment, it is the most effective and safe drug against allergies. Below is an annotation of Tsetrin and instructions for its use.

Name: Cetrin
Dosage: syrup is available in bottles of 30 and 60 ml. The weight of one tablet is 10 mg, one blister contains 10 tablets, and each carton pack contains 2 or 3 blisters.
Release form: coated tablets or syrup.
Impact group: respiratory system drug
Pharmacological group: antihistamine. Use orally.

Properties of the drug

Cetrin blocks H1-histamine receptors, providing antiallergic effect. The drug does not block serotonin and cholinergic receptors.

Doesn't cause frustration when used correctly nervous system and drowsiness. Thanks to the active substance Cetirizine, the agent effectively removes the manifestations of allergies at an early and late stage, and also reduces the migration of blood cells (, basophils and neutrophils). Cetrin is able not only to quickly relieve allergy symptoms, but also to prevent its occurrence.
Pharmacological properties of Cetrin tablets also include:

• Reducing smooth muscle spasm and delaying the onset of edema
• Reduced capillary permeability
• Elimination of skin reactions to allergens (for example)
• Reducing the manifestations of bronchial asthma

In most patients, improvement occurs within 60 minutes after taking the drug. Five percent of patients noticed a positive effect of the drug within twenty minutes after use. The duration of action is more than 24 hours. It is not addictive even after a long course of therapy, and after completion of treatment, the drug continues to act for 72 hours.

Main components and form of release

Cetrin tablets contain lactose, corn starch, sorbic acid, magnesium stearate, dimethicone, titanium dioxide, hypromellose, talc, povidone, polysorbate and macrogol as excipients. Each tablet contains 10 mg of the active ingredient cetirizine dihydrochloride. The tablets have a round convex shape and are covered with a white shell. The average price for the drug ranges from 140 to 220 rubles.

Cetrin syrup is often colorless, sometimes slightly yellowish, of a homogeneous structure with a pronounced fruity odor. One milliliter of syrup contains 1 mg of cetirizine. Additional ingredients are purified water, glycerol, sucrose, disodium edetate, benzoic acid, sodium citrate, sorbitol solution, and fruit flavor. The cost of the syrup is about 130 rubles.

Analogs of the remedy are Zetrinal, Zirtek, Zodak, Parlazin, Anallergin. All of them are produced in different forms(tablets, drops and syrups).

Application features

Cetrin for children in syrup and tablets for adults is equally well absorbed by the digestive system. The drug can be taken with food, and the maximum content of the active substances of the drug in the blood occurs an hour after ingestion.

The half-life of the drug from the body is 10 hours, but it can increase by half in elderly people and people with impaired liver function. In children, the drug is excreted longer (from two years - 3 hours, 2-5 years - 5 hours, up to 12 years - 6 hours). Mostly the drug is excreted in the urine, and only a small part of it is excreted during bowel movements. Cetrin tends to penetrate and accumulate in breast milk.

The appointment of Tsetrin for the treatment of allergies is carried out in the following cases:

• Seasonal or chronic conjunctivitis and rhinitis
• For treatment atopic dermatitis and with dermatoses accompanied by itching.
• To relieve itchy skin, urticaria, etc.
• At hay fever accompanied by sneezing, itching and increased tearing, as well as during atopic bronchial asthma.

Cetrin tablets for the treatment of adults and children over six years of age (daily intake - 10 mg / 1 tablet):

• Adults: 1 tablet per day
• Children after 6 years of age: half a tablet twice a day
• Patients with kidney disease halve the standard dosage.

The medicine should be taken with water.

Tsetrin syrup is best taken in the evening, but it is allowed to take the drug at any time of the day, regardless of food. The syrup should be taken with water.

• Children over six years old and adults: 10 ml (2 scoops) of syrup once a day. If necessary, the dosage is divided into two doses.
• Children 2-6 years old, people with kidney disease: 5 ml of the drug once a day or 2.5 ml twice a day.

The dosage of the syrup directly depends on the weight of the child. Babies up to 30 kg are prescribed one measuring spoon of the product, and if they weigh more than 30 kg - 10 ml or 2 measuring spoons.

Side effects

In most patients, Cetrin does not cause side effects... But in some cases, such adverse effects can be observed:

• Central nervous system disorders: headache, migraine, general weakness, increased sleepiness, nervous excitement, dizziness.
• Digestive organs: pain and discomfort in the abdomen, dry mouth,.
• Less commonly, urticaria, itching, swelling and other manifestations of allergies occur.

With a severe overdose of the drug (exceeding the therapeutic norm by 30-40 times), pronounced allergy symptoms appear: rash, itching, tachycardia and dry mouth. Exceeding the dose may also be accompanied by urinary retention, constipation, increased weakness and fatigue, and trembling of the limbs.

To eliminate the consequences of an overdose, gastric lavage is performed, and when grave condition the patient is given additional symptomatic therapy.

Cetrin and pregnancy

During the drug test, no negative effects of Cetrin on the fetus were noticed. However, insufficient research on the possible risks to the fetus makes Cetrin unsuitable for use during pregnancy and lactation.

The main contraindications

Patients with hepatic insufficiency are advised to use Cetrin in limited quantities and only after the dosage is prescribed by a doctor. Children under one year old and elderly patients are advised to use the product only when absolutely necessary and with great care. Contraindications for the drug also include:

• Pregnancy and lactation
• Individual intolerance or hypersensitivity to drug components
• Children under two years old (syrup), children under six years old (tablets).

Use with other medicines

Studies have shown that Cetrin does not interact with such drugs: glipeside, diazepam, ketoconazole, cimetidine and analogues. The simultaneous administration of Cetron and theophylline reduces the antihistamine effect of Cetron. Carefully take the drug together with sedatives.

Knowing exactly what the Cetrin tablets are prescribed for, you can avoid a negative reaction of the body. If the dosage is observed, the drug does not enhance the effect of ethanol, but the simultaneous use of alcohol is still not recommended.

Syrup Cetrin, according to studies, does not affect the speed of the reaction, but if the dosage is exceeded (10 mg per day), it slows down the psychomotor system. Therefore, Tsetrin is prescribed with caution to patients working with mechanisms, in transport or production requiring high concentration attention.

Cetrin ( Cetrine) - a modern antihistamine drug that has antiallergic, antiexudative, antipruritic effect. The drug is manufactured by the Indian pharmaceutical company Dr. Reddy's Laboratories Ltd.

In the pharmacy network, Cetrin is presented in the form of tablets containing 10 mg of Cetirizine, 20 tablets in a blister pack and in the form of a syrup containing 1 mg of Cetirizine in 1 ml.

How does Cetrin work for allergies?

The active substance of Cetrin is cetirizine (a metabolite of hydroxyzine), which is a blocker of H1-histamine receptors, a competitive antagonist of histamine. Ceterizine effectively relieves the manifestations of allergies, and also prevents its development. Possessing anti-exudative and antipruritic action, Ceterizin helps to limit the release of inflammatory mediators, prevents the release of histamine, serotonin, bradykinin by mast cells, reduces capillary permeability, prevents the migration of neutrophils, basophils, eosinophils, relieves smooth muscle spasm. In the treatment of mild bronchial asthma, Cetrin reduces histamine-induced bronchospasm.

When taking therapeutic doses of Tsetrin, there is no sedative effect. The therapeutic effect after taking 10 mg of the drug is noted after 30-60 minutes and lasts 1 day. Addiction to the antihistamine effect does not develop at therapeutic dosages. After stopping the intake of Tsetrin, the effect lasts for 3 days.

The active ingredients are a part of Tsetrin:

• Tablets: the active substance is cetirizine dihydrochloride (10 milligrams); excipients: starch, povidone, lactose, magnesium stearate, macrogol 6000, hypromellose, talc, titanium dioxide, polysorbate.
• Syrup: 1 ml contains 1 mg of cetirizine dihydrochloride; excipients: sucrose, glycerol, disodium edetate, benzoic acid, sodium citrate, sorbitol solution 70%, purified water, flavor.

Ceterizin after oral administration is absorbed rather quickly, the maximum plasma concentration is observed after 60 minutes. The drug is recommended to be taken before meals, as the digestion processes slow down its absorption.

A small amount of Cetirizine is metabolized in the liver. The drug does not have a cumulative effect (does not accumulate in organs and tissues), penetrates into breast milk, and is excreted from the body mainly by the kidneys.

In case of impaired renal excretory function, the half-life of the drug increases.

For what diseases is Cetrin prescribed?

Indications for the use of Tsetrin are allergic diseases:

• Seasonal and perennial rhinitis, conjunctivitis;
• Drug and food allergies;
• Dermatoses of allergic genesis (in complex treatment);
• Chronic recurrent urticaria;
• Quincke's edema;
• Atopic dermatitis (in complex treatment).

Contraindications and side effects

When treating with Cetrin, side effects may occur: headaches, dizziness, drowsiness, insomnia, hand tremors, depressive conditions. Also possible: dry mouth, nausea, vomiting, increased heart rate, increased blood pressure, allergic reactions.

Contraindications to the appointment of Tsetrin are:

• Intolerance to the components of the drug;
• Pregnancy and lactation period;
• For children under 6 years old, Tsetrin is prescribed in the form of a syrup.

Ways of using Tsetrin

Tsetrin tablets are taken orally before meals with a small amount of water.

Adults and children over 12 years old are prescribed 1 tab. (10 milligrams) once daily.

For children over 6 years old, give half a tablet (5 milligrams) twice a day.

Cetrin syrup is prescribed for adults and children over six years of age from 1 to 2 teaspoons (5-10 milligrams) once a day. For children from two to five years old, they give ½ tea. spoon once a day.

With hepatic and renal failure, adults are prescribed half a tablet (5 milligrams) once a day.

The course duration of treatment is 1-4 weeks. In the treatment of chronic allergic diseases, the duration of therapy can be increased up to 6 months. Read the instructions for use before taking Cetrin.

Can Cetrin be prescribed during pregnancy and lactation?

The active substance Cetirizine penetrates the placental barrier, is found in breast milk, having a negative effect on the condition of the fetus and newborn, therefore the drug is contraindicated in pregnancy and lactating breast milk.

Interaction with other medications

Tsetrin is used with caution in conjunction with sedatives. With simultaneous administration with theophylline, there may be an accumulation of Cetirizine and an overdose phenomenon.

An overdose of the drug is possible if the recommended dose is accidentally exceeded, accompanied by drowsiness, increased heart rate, hand tremors, pruritus, urinary retention. It is recommended to cancel the drug, gastric lavage, as well as the intake of enterosorbents: Polysorb, Enterosgel, Enterosorb, Lactofiltrum, Activated carbon. There is no specific antidote.

Are there analogues of Cetrin?

How to store the medicine correctly?

Store cetrin in a dark place. Storage temperature 15 to 25 degrees Celsius. The shelf life of the medicine is two years.

The price of a medicine in a pharmacy network

Cetrin can be purchased at most drug stores. The average cost of the drug is:

• Cetrin syrup, 60 ml (1 mg / ml) - 95 - 105 rubles;
• Cetrin tablets (10 mg), No. 20 - 160 - 170 rubles.

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Cetrin and pregnancy: the concepts are incompatible

Allergy in pregnant women most often manifests itself in the form of an allergic rhinitis or conjunctivitis. Less commonly, there are skin rashes and bronchial asthma. In all these cases, obstetricians-gynecologists recommend preparing for pregnancy, visiting an allergist in advance and, if necessary, conducting a course of specific treatment.

What to do if allergies get worse during pregnancy

First of all, no amateur performance: all treatment should take place only under the supervision of a doctor. First, the doctor will try to cope with allergies in a drug-free way: a hypoallergenic diet, excluding possible household allergens (including dust, particles of animal hair, fish scales, and so on).

If it is not possible to help the woman in this way, then drug treatment, including the use of the safest antihistamines.

What is the danger of antihistamines during pregnancy

Antihistamines are used during pregnancy, but only on strict indications. The fact is that drugs in this group block the action of histamine, a biologically active substance that is not entirely superfluous in the body of a pregnant woman.

With the assistance of histamine, the fertilized egg is introduced into the wall of the uterus and the embryo develops in it. In later stages of pregnancy, histamine easily crosses the placenta and regulates the metabolism between the mother and the fetus. The process of laying tissues and the development of fetal organs depends on its effect.

The use of antihistamines drugs can disrupt all these processes. And since there are practically no clinical trials on pregnant women, no one can say for sure how this or that antihistamine will affect the condition of the woman and the fetus.

In the first 12 weeks of pregnancy, these drugs cannot be used categorically, but in the future they are used with caution, taking into account all the indications and contraindications, the condition of the woman and the fetus is still sometimes used. But since there are no carefully tested and absolutely safe antihistamines among antihistamines, their use should take place under the constant supervision of a doctor.

How does cetrin affect pregnancy?

Cetrin is devoid of many of the shortcomings of its predecessors, but, just like them, cetrin suppresses the action of histamine, therefore it cannot be absolutely safe. Manufacturers of the drug (Indian pharmaceutical company Dr. Redi's Laboratories LTD) takes into account possible consequences the use of this antihistamine on a pregnant woman and fetus and therefore does not recommend its use during pregnancy.

How dangerous is cetrin for a pregnant woman and a fetus? No one will answer this question, since adequate clinical research this drug has not been tested on pregnant women. V clinical practice also, there is not yet enough experience with its use in pregnant women, since it is a relatively new drug.

The main thing that a pregnant woman should know is that she can take any pills only as directed by a doctor, but not on her own.

Questions and answers

• How quickly does Cetrin ® begin to act?

Cetrin ® begins to act within 20 minutes after taking and quickly removes various symptoms allergies.