Ranitidine Tablets Indications for use. Reviews for Ranitidine. Special groups of patients
Ranitidine: Instructions for use and reviews
Latin name: Ranitidin.
ATX code: a02w02
Active substance: Ranitidine (Ranitidine)
Manufacturer: Tyumen Chemical Pharmaceutical Plant (Russia), North Star CJSC (Russia), Ozon LLC (Russia), OJSC Aveksim (Russia), Sopharma (Bulgaria), Hemofarm (Serbia), Shreya Life Sciences ( India), Panacea Biotec (India), Jaka-80 (Macedonia), FC "Health" (Ukraine), Mapichem (Switzerland) and others
Actualization of the description and photo: 14.08.2019
Ranitidine is an anti-sized drug that blocks H 2-pistamic receptors.
Release form and composition
Dosage form - Tablets covered with film shell: round shape, double-screw, light orange (in blisters of 10 tab., 2 blisters in a carton box).
The active ingredient: Ranitidine (in the form of hydrochloride) - 150 or 300 mg in 1 tablet.
Auxiliary components: collideon VA-64, corn starch, silicon colloidal dioxide, propylene glycol, polyethylene glycol 6000, sodium lauryl sulfate, hypimon, magnesium stearate, ethylcellulose, microcrystalline cellulose, titanium dioxide, dye solar sunset yellow.
Pharmacological properties
Pharmacodynamics
Ranitidine - histamine H 2 Blocker Parietal cells, constituting the gastric mucous membrane. It suppresses basal and stimulated hydrochloric acid production caused by the food load, irritation of baroreceptors and effects characteristic of biogenic stimulants (pentagastrine, gastin, histamine) and hormones. Ranitidine helps to reduce the volume of gastric juice and the concentration of hydrochloric acid in it and increases the pH of the contents of the stomach. This explains the reduced activity of pepsin during treatment with the drug. The duration of its action after one-time reception is about 12 hours.
Pharmacokinetics
When oral administration, the bioavailability of ranitidine is approximately 50%. The substance is associated with plasma proteins by no more than 15% and partially participates in the metabolic processes occurring in the liver. Its maximum plasma content is reached 2 hours after receiving tablets. The half-life of Ranitidine is 2-3 hours. Approximately 30% of the adopted dose of the drug is excreted through the kidneys unchanged, a slight amount of ranitidine - through the intestine. The substance penetrates through the placental barrier and is determined in breast milk.
Indications for use
- Exacerbation peptic disease stomach and 12 pans (treatment and prevention);
- Zollinger-Ellison syndrome;
- Erosive esophagitis and reflux-esophagitis;
- Ulcer of the stomach and 12-rosewood, developed due to the admission of nonsteroidal anti-inflammatory drugs (NSAIDs);
- Postoperative and stressful ulcers of the upper departments gastrointestinal tract (treatment and prevention);
- Prevention of Mendelssohn syndrome (gastric juice aspiration) during operations with the use of general anesthesia;
- Prevention of recurrence of bleeding from the upper departments of the gastrointestinal tract.
Contraindications
Absolute:
- Children's age up to 12 years;
- Pregnancy and lactation period;
- Individual increased sensitivity to ranitidine components.
Relative:
- Liver cirrhosis with portoystene encephalopathy in history;
- Hepatic and / or renal failure;
- Acute porphyria, as anamnesis, including.
Instructions for the use of Ranitidine: Method and dosage
Ranitidine tablets should be taken inside: swallowed entirely and drink sufficient liquid. Meal does not affect the effectiveness of the drug.
- Georny disease of the stomach and a 12-roll intestine: treatment of exacerbations - 150 mg in the morning and evening or 300 mg per night, in some cases it is possible to increase the dose to 300 mg 2 times a day, a course of treatment - from 4 to 8 weeks; Prevention of exacerbations - 150 mg 1 time per day for night, smoking patients - 300 mg per night;
- Georny disease due to the reception of the NSAID: treatment - 150 mg in the morning and evening or 300 mg at night a course of 8-12 weeks; Prevention - 150 mg in the morning and evening;
- Postoperative and stressful ulcers: 150 mg 2 times a day for 4-8 weeks;
- Zollinger-Ellison syndrome: 150 mg 3 times a day, if necessary, the dose is raised;
- Erosive reflux-esophagitis: 150 mg in the morning and evening or 300 mg per night, in some cases the doctor may increase the dose to 150 mg 4 times a day, the duration of therapy is 8-12 weeks. If necessary, long-term preventive therapy is prescribed 150 mg 2 times a day;
- Prevention of recurrent bleeding from the upper gastrointestinal tract: 150 mg 2 times a day;
- The prevention of Mendelssoh's syndrome: 150 mg in the evening before the operation, then 150 mg 2 hours before anesthesia.
In renal failure (creatinine clearance less than 50 ml / minute), the daily dose should not exceed 150 mg.
Patients with associated disorders of the liver function may also require a decrease in the daily dose.
Side effects
- Allergic reactions: bronchospasm, skin rash, urticaria, anaphylactic shock, swelling of quinque, multiform erythema;
- From the side of the cardiovascular system: atrioventricular blockade, bradycardia, reduction arterial pressure, arrhythmia;
- From the musculoskeletal system: Malgy, Arthralgia;
- From side nervous system: Headache, drowsiness, dizziness, increased fatigue; rarely - noise in ears, involuntary movements, irritability, confusion of consciousness, hallucinations (more often in older people and severe patients);
- From the blood formation organs: hypo- and aplasia of bone marrow, agranulocytosis, immune hemolytic anemia, thrombocytopenia, leukopenia, pancytopenia;
- From side digestive system: dry mouth, abdominal pain, diarrhea / constipation, nausea and / or vomiting; rarely - acute pancreatitis, cholestatic, hepatocellular or mixed hepatitis;
- From side endocrine system: Amenorrhea, gynecomastia, decreased libido, hyperprolactinemia, impotence;
- From the sides of the senses: paresis accommodation, the fuzziness of visual perception;
- Others: hypercreaticinemia, alopecia.
Overdose
Under the overdose of Ranitidine, the following symptoms may be observed: ventricular arrhythmias, bradycardia, convulsive seizures. In this case, symptomatic therapy is recommended, as well as washing the stomach and / or induction of vomiting. If convulsive seizures occur intravenously administered to diazepams. At the bradycardia are prescribed athropic, and with ventricular arrhythmias - Lidocaine. Hemodialysis is considered an effective procedure for the removal of ranitidine.
special instructions
Due to the fact that Ranitidine can mask the symptoms characteristic of the stomach carcinoma, before it is necessary to eliminate the presence of oncology.
In the period of therapy, it is recommended to refrain from drinking beverages, food and drugs that can irritate the gastric mucosa, as well as from driving a car and perform potentially dangerous work that requires the speed of psychophysical reactions and increased attention.
In weak patients with long use The preparation under stress conditions are possible bacterial gastric lesions with the subsequent spread of infection.
Like all H 2-gestamiblocators, Ranitidine should not be canceled sharply (there is a risk of developing the "ricochet" syndrome).
If you need to simultaneously use, histamine H 2-receptor blockers need to be taken 2 hours after receiving ketoconazole / mineraconasol, it is possible to significantly reduce their suction.
According to the instructions, Ranitidine can increase the activity of glutamatranspendase.
There are separate data that the drug can cause sharp attacks of porphyria.
Gistamine H 2-receptor blockers can counteract the effect of histamine and pentagastrine on the acid-forming function of the stomach, so it is not recommended to be applied to them within 24 hours before the test.
During treatment with ranitidine, it is possible to obtain a false positive reaction when conducting a sample for a protein in the urine.
Since N 2-histimic receptor blockers can suppress the skin reaction to histamine, they should be canceled before conducting diagnostic skin samples to detect an allergic skin reaction immediately.
Medicinal interaction
It should be borne in mind that Ranitidine:
- Inhibits metabolism in the liver indirect anticoagulantov, calcium antagonists, aminofenazone, glipizid, diazepam, lidocaine, metronidazole, propranolol, tapeson, theophylline, hexobarbital, bufform, aminoophylline, phenytoin;
- Increases the concentration in serum and the half-life of metoprolol;
- Reduces the absorption of ketoconazole and itraconazole.
Smoking reduces the effectiveness of the ranitidine.
With the simultaneous use of drugs that affect the oppressive effect on bone marrow Risk of neutropenia is increasing.
Antacid agents and sukralfat in high doses can slow down the ranitidine absorption, therefore, 2-hour intervals should be observed between the techniques.
Analogs
Analogues of the ranitidine are: Ranitidine Sofarma, Atzilok, Ranisan, Ranitidine-Lect, Zantac, Ranitidine-Akos, Histak, Zoran, Ranitidin-Feren, Ulran.
Terms and conditions of storage
Store in a dry, inaccessible place in compliance with the temperature regime 15-30 ° C.
Shelf life - 3 years.
Apo-Ranitidine; ASITEK; Accidex; Acylov; Vero-Ranitidine; Ranitidine gene; Geotloch; Hy-car; Hystak; Duoran; Zantak; Zantin; Zoran; Neameptine; Novo-Ranidine; Peptoran; Ranibl; Ranigast; Ranisan; Ranisson; Ranitab; Ranal; Ranitard; Ranitidine; Ranitidine Evaramed; Ranitidin Sediko; Ranitidine AKOS; Ranitidine Acry; Ranitidine apot; Ranitidine BMS; Ranitidine Vero; Ranitidine Ratiopharm; Ranitidine hydrochloride; Ranitine; Ranantag; Rank; Rintid; Ranks; Ulkodin; Ulkosan; Ulkuran; Ulran; Ulwex; Yazitin.
Ranitidine - Blocator H2-histamine receptors of the 2nd generation with strong and specific affinity for stomach parietal cells and providing a gastroselective action. It affects the main cause of heartburn and digestion disorders, normalizing the process of the production of acid in the stomach. Protection of the stomach for a long time. Gold Standard in the therapy of ulcer of the stomach and duodenal gut (including stress-ulcers, yatrogenic, NSAIDs-gastropathy, Zlinger-Ellison syndrome). It is also used in comprehensive therapy aimed at eliminating Helicobacter Pylori, with erosive and reflux-esophagitis, ugly dyspepsia.
What do you know about the Blockers of H2-histamine receptors?
Preparations blocking receptors to histamine carry out their action, occupying receptors on fat cells, but without causing further reaction. They are competitive reversible antagonists of histamine.
The main effect of histamine on H2 receptors is to stimulate the secretion of acid in the stomach. It is well known that histamine is an important mediator of acid secretion caused by all physiological incentives, for example, food, acetylcholine, gastrine, etc. H2-blockers do not act on H1 receptors.
The blockade of H2 receptors effectively suppresses day and night basal secretion of gastric acids, as well as secretion, stimulated by various secretory stimuli, including histamine, caffeine, food, etc. Therefore, H2 receptor blockers are an effective approach to the treatment of hypersecreator states and, undoubtedly, are a group of the most active drugs from all that are used now to relieve ulcerative pains and accelerate the healing of the ulcers.
The first H2 receptor antagonist, which has become widely used to treat peptic ulcers, was cimetidine.
Ranitidine / Ranitidine hydrochloride / Ranitidine.
Tablets (pills are hidden).
Injection.
Ranitidine
Ranitidine is a highly active histamine H2 receptor blocker. Ranitidine refers to the II generation of H2-histamine receptor blockers. It has a strong and specific affinity for stomach parietal cells and has a gastroselective action.
The main effect of ranitidine is aimed at reducing the aggressiveness of the gastric juice.
Ranitidine suppresses basal and stimulated by histamine, gastrine, pentagastrine and acetylcholine (to a lesser extent) secretion of hydrochloric acid. Ranitidine reduces both the volume of the gastric juice allocated and the concentration of hydrogen ions in it (increases the pH). Reduces pepsin activity.
In addition, Ranitidine slows down the degradation of fat cells, reduces the content of histamine in the periulhesive zone and stimulates the processes of healing of ulcers, increasing the number of DNA-synthesizing epithelium cells.
Ranitidine increases the glycserobolipid content, which can have a beneficial effect on healing of peptic ulcers (Sarosiek J. et al.).
Ranitidine increases the tone of the lower esophageal sphincter. This can contribute to the prevention of the cast of acidic and peptic content of the stomach in the esophagus.
Animal studies have shown that Ranitidine suppresses the formation of the stomach and duodenal ulcers, which are generated under the action of stress, histamine and NSAID (for example, aspirin, indomethacin).
In patients with peptic ulcers, Ranitidine significantly reduces the daily intragastric acidity and, especially, the night secretion of acid, thereby biving pain and contributing to the rapid healing of ulcers.
Ranitidine does not affect the concentration of gastrine in serum, the secretion of the internal factor, the pancreatic function, as well as the duodenal motorcy and the time of emptying the stomach.
Ranitidine is 3-5 times more active than cimetidine and acts longer. After oral application 150 mg of ranitidine effect occurs after 30 minutes; Its plasma concentration is sufficient to inhibit the secretion of acid for 12 hours. A single evening dose of 300 mg of raniotidine is sufficient to inhibit the secretion of gastric acid over the night and the next day.
Ranitidine practically does not affect hormonal status, immunological reactivity, liver microsomal enzymes and biotransformation of other drug compounds.
In contrast to other antagonists containing an imidazole ring, an aminoalkyl furan ring is included in the rinitidine structure, replacing the imidazole ring in cimetidine. Due to the unique structure, the action of the ranitidine on H2-receptors of the stomach is highly selected.
An important advantage of ranitidine compared to cimetidine is that it does not associate with the hepatic enzyme system of cytochrome R-450, which is responsible for metabolism various drugs. Thus, Ranitidine does not lead to any clinically significant drug interactions With preparations such as propranolol, oral anticoagulants, theophylline, digoxin, diazepams, etc. in patients with several diseases that can interact with cimetidine, Ranitidine has an explicit advantage.
It is known that cimetidine violates the hormone equilibrium, binding to the receptors to androgen. This imbalance can lead to an increase in prolactin concentrations, loss of libido, impotence and gynecomastia. These symptoms were often noted in the treatment with large doses, for example, with Zolinger Ellison syndrome. Sometimes even standard doses could cause the specified adverse reactions. Against the background of treatment with Ranitidine, these adverse reactions, on the contrary, are not only expressed slightly and developing rarely, but also disappear if they were caused by the preceding Cimetidine therapy.
Therapeutic doses of ranitidine do not affect the heart rate in peace or blood pressure. Cimetidine can cause confusion of consciousness, especially in patients of senile age. Ranitidine rarely leads to by-road reactions from the CNS.
The above-described actions on the liver metabolism of drugs, endocrine function and CNS are connected mainly with a dose, that is, they are observed in the treatment of cimetidine, since the latter has to be prescribed in large doses. Against the background of therapy with Ranitidine or Famotidine, these reactions are rare.
Ranitidine is well absorbed from the gastrointestinal tract. When taking inside, the bioavailability of ranitidine is 40-80%. The maximum concentration in the blood plasma is reached 1-3 hours after intake. Eating and antacids slightly affects the degree of suction.
After the I / M of the introduction quickly and almost completely absorbed from the injection site. Cmax is achieved after 15 minutes.
The binding of ranitidine with proteins is about 15%.
The half-life of Ranitidine ranges from 2 to 2.5 hours. 10 hours after the purpose of 150 mg of Ranitidine, the suppression of acid secretion of the stomach is still significantly expressed.
Ranitidine is metabolized in the liver, exposed to the effect of the "first passage" through the liver. It is displayed mainly with urine. About 30% oral dose is excreted in the urine unchanged, and about 8% in the form of metabolites. The residue is excreted with the feces. The rate of excretion is reduced by impaired liver or kidney function.
Ranitidine can pass through the placenta and stands out with breast milk.
Indications:
Method of use and dose:
Dosing mode is installed individually. The duration of treatment is determined by the testimony to use.
Adults and children over 14 years old:
The recommended dose of the ranitidine during the exacerbation of the duodenal ulcers or benign stomach ulcers is 300 mg, which are divided into two receptions (150 mg in the morning and evening) or take 300 mg once a day. If necessary, the daily dose of the drug can be increased to 450 mg. Treatment must be continued to scarring ulcers or if the re-examination is not possible, within 4-8 weeks. In most cases, duodenal and gastric ulcers Heat after 4 weeks. In some cases, it may be necessary to continue treatment up to 8 weeks. When treating ulcerative disease, a sharp abolition of the drug is not recommended (especially before the scarring of ulcers), it is usually recommended to transition to a supporting dose of 150 mg per night.
For the prevention of peptic ulcer of the stomach and / or duodenum, 150 mg of the preparation is prescribed 1 time / day before bedtime in the flows.
In the occurrence of postoperative ulcers, Ranitidine is prescribed 150 mg 2 times / day. Healing usually occurs within 4 weeks.
For the prevention of stressful ulcers in severely ill patients, the drug is prescribed 150 mg 2 times / day.
For states with pathological hypersecretion, for example, Zolinger-Ellison syndrome, recommended by the dose of ranitidine equalsimensing a day in 3 receptions. In severe cases, doses were used to 6 g per day, which were well tolerated by patients.
With reflux-esophagite, the recommended dose is 150 mg twice a day for 8 weeks, if necessary to 150 mg 4 times a day. In addition, the improvement of the state will contribute to lifting the head end bed and treatment of metoclopramide.
In the treatment of non-ugly dyspepsia and gastritis, a shorter course is possible. In many countries, Ranitidine 75 mg is sold as a drug of non-receptible vacation for use with a nonsense dyspepsia by 75 mg 4 times a day.
To eliminate Helicobacter pylori, Ranitidine can be used according to the following scheme: $ 150 mg twice per day in a complex with amoxicillin 500 mg 4 times a day, or a tetracycline of 500 mg 3 times a day or a clarithromycin 250 mg 4 times a day. Then 18 days of Ranitidine 300 mg per night.
Shown high efficiency The following scheme: Ranitidine 300 mg twice a day, clarithromycin 250 mg 2 times a day, metronidazole 500 mg 2 times a day for 14 days, then receiving ranitidine for another 4 weeks.
The usual dose for the prevention of recurrent gastrointestinal bleeding in patients with ulcerative disease is 150 mg twice a day.
Surgical patients who have the risk of aspiration of gastric content, you need to give 300 mg of ranitidine inside in the evening before the operation.
Children Assign inside 2-4 mg / kg 2 times a day with a stomach and duodenal ulcer (maximum / day), with reflux-esophaghetteg / kg 3 times a day.
Surgical patients at risk of aspiration of gastric contents (including for childbirth), for prophylaxis gastric bleeding and stressful ulcers: 50 mg in / in or V / m Zamin to anesthesia, then ending (2-4 ml) in / m or in / every 6-8 hours.
A / m is introduced 50 mg of ranitidine without breeding.
For in / in administration of 50 mg, up to 20 ml are diluted in the corresponding solution and introduced in / in slowly for 5 minutes (rare cases of bradycardia are described with rapid administration).
For B / in drip administration, 50 mg is dissolved not more than 100 ml and administered at a speed of 25 mg / h.
Ranitidine Injection is usually compatible with the following solutions: 0.9% sodium solution chloride, 5%, 10% dextrose, Ringer lactate, 5% sodium bicarbonate for injections.
In patients with severe renal failure, the dose should be reduced. Patients with creatinine clearance less than 50 ml / min, daily dose Ranitidine must be reduced to 150 mg per day (75 mg 2 times / day). The appointment of half of the usual dose creates adequate concentrations of the drug in the plasma without signs of its cumulation.
Treatment: induction of vomiting or washing of the stomach, during convulsions - diazepams in / in, in bradycardia - atropine, with ventricular arrhythmias - lidocaine.
Contraindications:
Restrictions on use: liver cirrhosis, renal impairment.
Application during pregnancy and lactation:
Ranitidine passes through the placenta and secrets into breast milk.
Adex-wage and well-controlled research of safety of the use of ranitidine during pregnancy was not carried out, and therefore the use during pregnancy is contraindicated. Ranitidine can be assigned during pregnancy only by absolute indications.
If necessary, the use of Ranitidine during lactation should be stopped breastfeeding.
Ranitidine is considered a preparation with high security. As in short-term and long-term studies, Ranitidine was moved well. The frequency of side action is low and comparable to such on placebo.
From the side of the cardiovascular system: in isolated cases, arrhythmias (tachycardia, bradycardia, asistolia, AV blockade, extrasystolia).
From the digestive system: rarely - diarrhea, constipation, nausea, vomiting, meteorism, dry mouth; In isolated cases - hepatitis.
From the CNS: rarely - headache, dizziness, fatigue, drowsiness, blurredness; In isolated cases (in seriously ill) - confusion of consciousness, hallucinations. The confusion of consciousness and depression, which may be observed when taking cimetidine, especially in patients of senile age, is extremely rare with Ranitidine therapy.
From the system of blood formation: rarely thrombocytopenia; With long-term use in high doses - leukopenia.
From the metabolism: rarely - a slight increase in creatinine in blood serum at the beginning of treatment (these changes are not clinically significant). Rare cases of interstitial necrosis, which were observed in the treatment of cimetidine, is not described for ranitidine.
From the endocrine system: with long-term use in high doses, it is possible to increase the content of prolactin, gynecomastia, amenorrhea, impotence, a decrease in libido. Patients, poorly carrying cimetidine, were translated into Ranitidin, while the relapses of side effects of the type of gynecomastia and impotence were not.
From side bone-muscular system: Very rarely - Arthralgia, Malgy.
Allergic reactions: rarely - skin rash, urticaria, angioedema edema, anaphylactic shock, bronchospasm, arterial hypotension.
Others: rarely - recurrent vapotitis; In isolated cases - hair loss.
Special instructions and precautions:
With caution prescribe a drug to patients with severe disorders of the liver function and / or kidney. Since the ranitidine is excreted mainly by the kidneys, patients with severe renal failure of its dose should be reduced. The dose must be reduced in severe liver failure. In senior patients with impaired liver or kidney, it is possible a disorder (confusion) of consciousness, which causes the need to reduce the dose. There are separate reports that Ranitidine can contribute to the development of an acute attack of porphyry, and therefore it is necessary to avoid its use in patients with acute porphyrene in history.
Ranitidine treatment can mask the symptoms of malignant tumors of the stomach. Before starting the use of the drug, it is necessary to eliminate the presence malignant disease esophagus, stomach, duodenum.
An undesirable discontinuation of the reception of the ranitidine due to the danger of recurrence of ulcerative disease. If it is necessary to cease treatment, the drug is canceled, gradually reducing the dose.
With long-term treatment in weakened patients under stress conditions, bacterial gastric lesions are possible, followed by the spread of infection.
Efficiency preventive application Ranitidine when taking the drug by courses for 45 days in the spring-autumn period is higher than with its constant reception.
Instant tablets contain sodium, which must be considered when prescribed by patients who are shown to limit its reception, and aspartame, unwanted for patients with phenylketonuria.
The rapid / in the introduction of Ranitidine in rare cases causes bradycardia, usually in patients predisposed to violation of the heart rhythm.
Against the background of the use of Ranitidine, distortion of laboratory research data is possible: increasing the level of creatinine, the activity of gamma-glutoratranspendase and liver transamamine in blood plasma.
Clinical data on the safety of ranitidine in pediatrics are limited.
Antacids and sucralfat can reduce absorption. In cases where Ranitidine is used in combination with antacids, the break between the reception of antacids and the ranitidine should be at least 1-2 hours. With the simultaneous use of ranitidine with a suction of high doses (2 g), a breaking of the ranitidine suction is possible, so the break between the reception of these medicines There must be at least 2 hours.
Ranitidine minimally inhibits the hepatic metabolism of kumarine derivatives, teofiline, diazepam, propranolol, glipezide, glipiside, glyburide, metoprolol, midazolam, nifedipine. With the simultaneous use of Ranitidine, it may increase the effect of indirect anticoagulants.
With simultaneous use with Ranitidine, it is possible to increase the concentration of phenyotine in the blood and an increase in the risk of ataxia development.
Ranitidine leads to inhibition of paracetamol metabolism, depending on the dose.
With simultaneous use with Ranitidine, the concentration of procanamide in the blood plasma increases due to a decrease in its rebel.
Propantelin-bromide is delayed by the resorption of the ranitidine, so that the relative biological availability of ranitidine is growing during the simultaneous use of two drugs.
Smoking reduces the effectiveness of the ranitidine.
Ranitidine changes the suction and excretion of other medicines (in accordance with their acid-base properties).
Store at room temperature in a place protected from light and moisture.
Keep out of the reach of children!
Shelf life is specified on the package. Do not use after the expiration date indicated on the package.
Vacation from pharmacies - by prescription.
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Ranitidine - instructions for use, composition, indications, analogues and reviews
The Ranitidine preparation is an anti-sized, antisecretory drug. Thanks to Ranitidin, the histamine H-2 selected recipers that are located in the gastric mucosa are blocked. The drug can be extinguished from heartburn. When assigned comprehensive therapy With many diseases gasts. Especially Ranitidine requires underlying patients who suffer from a violation of swallowing reflex and diseases of the gastrointestinal tract.
Composition and form of release
Ranitidine is produced in tablets. One tablet may contain 150 or 300 mg of active substance. Packaging has 10.20.30, 100 pieces of tablets. Ampoules 2 ml ampoules are produced for injections.
In one tablet, 150 mg with film shell contains ranitidine with hydrochloride form. With auxiliary substances: microcrystalline cellulose, sodium croscarmellosis, silicon with colloid dioxide, magnesium stearate. The shell consists of hypimlolose, triacenetin, titanium Dioxide E171, Talca.
In one tablet of the drug Ranitidine 300 mg with a film shell, besides all of the above presence of brownlak-dyes. The tableted form of a drug 150 mg is bobbly convex, white - yellowish-white color, with a characteristic smell. Tablets 300 mg have a pale pink color and characteristic smell.
Instructions for use in various dosage forms
Ranitidine: Application in the form of tablets
1 Tablet 150 or 300 mg of Ranitidine comprises: Ranitidine hydrochloride. Auxiliary components: microcrystalline cellulose, cornflower starch, collideon IA-64, silicon colloidal dioxide, magnesium stearate, hypronelosis, ethylcellulose, polyethylene glycol, 6000, propylene glycol, sodium lauril sulfate, titanium dioxide, dye sunny sunset yellow.
Ranitidine is accepted both before and after eating, drinking the ranitidine with water in large quantities. Must be to be the recommendation of the doctor. He prescribes a dose of medication, the term of treatment and additional preparations, for example, to neutralize the acidity of the gastric juice, it will prescribe an antacid drug. Tablets are not chewed and drove in large amounts of water. Produced, also swiming tablets. One tablet needs a glass of water so that it dissolved there. After its complete dissolution, the solution can be enjoyed.
The use of ranitidine at ulcer of the stomach and 12 pans
If the patient has a peptic ulcer of the stomach and a 12-rosewoman, then take 1 to 150 mg ranitidine tablets in the morning and evening day. Or 2 at 150 mg tablets immediately during a waste to sleep. If necessary, the dose of use increases to 4 to 150 mg of tablets per day. Usually the course of treatment takes from 1 to 2 months. In preventive measures, it is necessary to take the drug by Ranitidine 1 tablet for 150 mg per night. Smoking patients-2 tablets of 150 mg.
The use of ranitidine when applying the NLC
If the patient is taking a taking non-steroidal anti-inflammatory drugs, then treatment is prescribed: 150 mg per day, or 300 mg per night from 1 to 2 months. With prevention 2 times a day-150 mg.
Ranitidine: Application in the form of injections
Ranitidine solution for parenteral administration is made in ampoules. The injection in Vienna is slow, within 5 minutes. Breaks the drug with a 0.9% solution of chloride sodium or 5% dextrose. The dropper is set for 2 hours at the rate of 25mg / h. The muscle makes the injection from 3 to 4 times a day. Injections can apply children over 14 years old and adults. How many days to make injections, solves the attending physician. Everything will depend on the severity of the disease. The injections of the drug Ranitidine are prescribed: under the ulcer of the stomach, ulcerative disease 12 of the rosewood, with stressful and symptomatic ulcers. The injections of the drug Ranitidine patients with increased sensitivity to the contents of the drug are strictly prohibited. It is very important to track the time between injections.
The use of Ranitidine in Zlinger-Ellison syndrome
Zlinger-Ellison syndrome, with a combination of stomach ulcers and a benign tumor in the pancreas, the drug is accepted 3 times a day at 150 mg or 2 times a day at 150 mg 1-2 months. It all depends on the prescriptions of the doctor.
Indications, contraindications, side effects of Ranitidine
Indications for the use of Ranitidine
- In case of diseases, as well as preventive measures related to the exacerbation of the stomach ulcers, the 12-risos.
- With inflammation of the esophagus, if the integrity of its mucous membrane is disturbed, when throwing gastric content into the esophagus. Reflux Ezophagitis, erosive esophagitis. Apply: twice 150 mg in 24 hours. If the aggravation is 4 times, from 1 to 2 months.
- Syndrome Zolinger-Ellison. When the patient is combined with a gastric ulcer and a benign tumor in the pancreas.
- In the treatment and preventive measures of postoperative stomach ulcers.
- With prophylactic measures related to recurrences of bleeding of the upper gastrointestinal tract.
- In prevention, in the case of gastric juice in airways, during the operation under anesthesia, the aspiration of the gastric juice. 2 hours before anesthesia 150 mg and before operation in the evening 150 mg. If there is a concomitant violation of the liver, then the dose is underestimated. In the renal failure of the QC less than 50 ml / min, it is necessary to take the drug in the amount of 150 mg per day.
From which Ranitidine helps, from what diseases
It is used in preventive measures and in treatment. The doctor appoints a Panitidine patient if there is:
- Gastritis
- Stomach ulcer
- 12 rosisets
- Syndrome Zlinger Ellison,
- Gastrooforous reflux,
- Heartburn.
Gastric juice and hydrochloric acid decreases in terms of volume. There is a decrease in the acidity of the stomach, and the activity of pepsin falls. The gastric mucosa is improved, gives the background for healing the ulcers.
Ranitidine refers to those drugs that are possible when applied sideflines. Under the acceleration of Ranitidine, there may be side effects associated with the nervous, cardiovascular systems, with the gastrointestinal organs, with rash rash on the skin. Rarely patient can feel: headacheFatigue. In seriously ill drug, Ranitidine can cause a drowned state, dizziness, insonuations, vertigo, depression. In rare cases, after taking the tool, disorders associated with the confusion of consciousness, hallucinations, reversible vision, violation of the accommodation of the eyes may appear.
A person may feel: arrhythmia, such, bradycardia. It may feel a bad condition and in the gastrointestinal organs: nausea, vomiting, constipation, diarrhea. If Ranitidin is used in large doses (more than 450mg per day), then men can begin to increase the dairy glands, impotence will appear. Patients of both sexes will decrease libido. Women will have a violation of the menstrual cycle.
Contraindications for the use of ranitidine
It is impossible to use Ranitidin to the future mothers. For breastfeeding. Children under 12 years old. Patients with increased sensitivity to the drug. It is impossible to use food, beverages and drugs, acting negatively on the gastric mucous membrane. Also, it is not prescribed with increased sensitivity to the drug and its components.
Ranitidine: Overdose Symptoms
When making too much dose, the funds must necessarily call an ambulance. Because the head can be sprinkled, the coordination of movements will break, you can faint
Under the overdose of the use of Ranitidine, it is necessary to pay attention to the symptoms. If in the patient: a head got sick, dizziness began, he pulled him into sleep, began to be confused in thoughts, a rash appeared on the skin, I urgently need a doctor. And before arrival it is necessary to cause a patient a vomit reflex and then give activated coal. What to do if the patient did not take the dose of the drug on time? You can take it as soon as I remember it. And if the time comes to apply the next dose, it is not necessary to apply the missed tablet. It will be a doubling of a dose of medication that can badly affect well-being.
How long can I use Ranitidine
Ranitidine in tablets can be applied as much as the doctor will allow. Cancel the use of the drug must be gradually. In weakened patients have long been treated, diarrhea can develop. During treatment there is a decrease in the concentration of attention and psychomotor reactions. It is advisable to quit smoking during the preparation period. Refuse alcohol consumption. Smoking and alcohol irritate the mucous membrane of the stomach, and therefore the effectiveness of treatment with Ranitidine is reduced.
The use of ranitidine during pregnancy
It is not taken during pregnancy, lactation. The medicine is quickly absorbed, and his penetration concerns not only the placenta, but also the fetus. Clinical researches Not conducted. Therefore, there is no data on the use of it during pregnancy. In addition, he has side effects.
Ranitidine: Application for children
Ranitidine does not appoint children under 12 years old.
Therapeutic effects of Ranitidine
During the use of Ranitidine, there is a decrease in the basal and stimulated secretion of hydrochloric acid, which arises due to irritation of barroreceptors, food loads, hormone actions and biogenic stimulants. The medicine is valid for about 12 hours. It is available only in tablets with a film sheath of 150 mg, which dissolves after its adoption in the stomach.
For injections, a solution of ranitidine is used. If the patient came to a doctor with chronic diseases In the field of heart, with porphyria, diseases associated with the kidneys, with the liver, then he must tell about it. The doctor for each patient has an individual approach to the use of the drug. Do not forget that the conclusion of the drug Ranitidine is carried out by the kidneys, so the doctor will be able to write a small dose of the drug then with a violation of their work. Do not take the drug yourself. In any case, a specialist consultation is required.
Ranitidine interaction with other drugs
If you take increased doses of asits and sukralfat, the drug will be badly absorbed. Therefore, to use each raniotidine is needed after 2 hours with a break. If the ranitidine and procanamide is simultaneously used, the procainamide will be badly excreted by the kidneys. And the threat to increasing its plasma concentration will continue. Ranitidine can interact with such drugs as: Glipisid, Gaiburid, Metoprolol, Midazolam, Nifedipine, Phenitoin, Teophylline, Farfarin.
Ranitidine domestic and foreign
Ranitidine has the highest availability, that is, quantity medicinal substanceswho reach the place of action among their interchangeable analogues. The list of the most popular analogues of the Ranitidine preparation looks like this:
Treats heartburn, dyspeptic disorders, if not organic diseases in the digestive system.
Analogue of Ranitidine - Ranisan
It is used in the testimony: ulcer of the stomach and 12 pans, chronic gastritis, Zollinger-Ellison syndrome.
Apply under heartburn
Used when heartburn
They have one or more substances, with ranitidine, with the use of which act equally.
Price of the drug in pharmacies
Check out the price of Ranitidine in 2018 and cheap analogues \u003e\u003e\u003e The cost of the drug Ranitidine in different pharmacies can differ significantly. This is due to the use of cheaper components in the preparation, and the pricing policy of the pharmacy network. But it is important that the price difference between overseas and russian analogues It remains almost unchanged.
On Medmoon.ru. medications Classified both alphabetically and by action on the body. We are published only the most relevant and new drugs. Instructions for use Ranitidine is regularly updated at the request of manufacturers.
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How to take Ranitidin
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- What cheap analogs and substitutes are "Overty"
As the drug acts
Ranitidine refers to a group of histamine receptor blockers that reduce the production of hydrochloric acid and reinforcing the operation of the secrecy in the stomach and intestines. This leads to stabilization of the pH level of the gastric juice and contributes to the protection of cells from damage and education erosions. "Ranitidine" is produced in a tablet form and in the form of a solution for injections. The effectiveness of the effect of the drug does not depend on the time of meals.
Indications for the use of "Ranitidine"
Thanks positive impact drug on the mucous membranes of the stomach and intestines, it is successfully applied at complex treatment The ulcerative disease of the stomach and duodenal intestine, heartburn, gastrointestinal reflux and gastritis due to increased acidity.
How to use drug
The dosage "Ranitidine" depends on the purpose of its use. For example, when gastritis, the medicine is used for 1 tablet 2 times a day for 10 days.
Contraindications and side effects of "Ranitidine"
Take the drug is not recommended for pregnant women, while breastfeeding and children under three years old, since there are no reliable data about unwanted impact Medicines on the body. "Ranitidine" is contraindicated in gastritis with reduced acidity and insufficient developing of digestive enzymes.
Diseases of the gastrointestinal tract - an extremely common problem, from which people suffer regardless of age and gender. For example, gastritis is often diagnosed among adolescents, and sometimes young children. Fortunately, modern medicine offers a lot of inflammatory processes of the digestive tract. And one of them is the drug "Ranitidine". Indications for use of this medication is very wide. So what is included in his composition and how effective is this tool?
Preparation "Ranitidine": composition and form of release
The main active substance of the drug is rainitidine hypochloride. In natural form, it is a granulated white powder (sometimes with a yellowish tint) with a characteristic smell of sulfur and bitter taste. This substance has antagonistic properties with respect to histamine H2 receptors.
The drug is produced either in the form of tablets, or in the form of a solution for intramuscular or intravenous administration. There are so-called "effervescent" tablets for the preparation of aquatic solution.
Tablets have a round, two-way shape, covered with light orange shell on top. As auxiliary substances are used: sodium lauryl sulfate, colloid corn starch, magnesium stearate, hypimon, polyethylene glycol 6000, ethyl cellulose and yellow dye.
To date, pharmacological companies offer tablets, which contain either 150 mg, or 300 mg of active substance. We are produced in 2 ml glass ampoules.
Pharmacological properties of the drug "Ranitidine"
As mentioned, the main active substance of the drug blocks H2-reviews of histamine. This medicine affects mainly the work of the stomach mucosa parietal cells. Under its influence, the extraction of hydrochloric acid is oppressed, which leads to a decrease in the volume of its acidity released as well. By the way, that is why Ranitidine preparation from heartburn is very effective.
It is worth noting that histamine receptor blockers reduce the concentration of digestive enzymes (pepsin) in gastric juice. The oppression of secretion creates optimal conditions for healing ulcers on the mucous membrane, which naturally accelerates the process of cure.
Moreover, active components The drug affects the gastroduodenal zone, increasing the activity of local protective mechanisms, increasing the allocation of protective mucosa secret. The drug also speeds up regeneration processes.
At the same time, the medicine does not have some dangerous impact on the body. In particular, it does not affect the concentration of calcium ions in the blood, does not disrupt the work of the endocrine system, does not affect the processes of spermatogenesis. The results of the research also showed that the drug does not have a carcinogenic effect and does not cause mutations. On the other hand, the active substance penetrates through the placental barrier and in breast milk.
After taking the medicine is quickly absorbed by the wall of the digestive tract. The maximum concentration in the blood is observed already after 2-3 hours. In most cases, the effect is kept for about 12 hours. In the process of metabolism, partially converted into the liver. Fully excreted from the body to kidney during the day after admission.
Preparation "Ranitidine": Indications for use
This medicine is widely used as nonetheless, there are a lot of violations, in which doctors prescribe a "Ranitidine" medicine. Indications for use are as follows: 
It is worth noting that acute diseases - Not the only aids requiring treatment with the help of the drug "Ranitidine". Indications for use include the prevention of exacerbations of chronic gastritis and ulcerative disease.
How to take a medicine?
Of course, before the use of this medicine requires a doctor consultation. All doses are determined individually, as they depend on the age and state of the patient, the form of the disease, the purpose of reception (treatment or prevention):
- Adult patients are shown to receive tablets with a dose of an active substance of 150 mg twice a day. In some cases, doctors recommend taking two pills at once before bedtime.
- For the prevention of bleeding, the patient is injected intramuscularly (or intravenously) at 0.05 - 0.1 g with a periodicity of 6-8 hours (if necessary, the dose can be increased to 0.9 g).
- Teens, as a rule, take 150 mg twice a day.
- In the treatment of benign tumors, the recommended dose is 150 mg of the active substance three times a day.
As a rule, the duration of treatment is from four to eight weeks. If it comes to prevention, then some patients are recommended to take the drug for several months, and sometimes a whole year, but under constant supervision of the doctor and with regular endoscopic studies.
Contraindications for the use of the "Ranitidine" medicine
Like any other medicine, this drug can be used not every patient. In particular, it is forbidden to apply for the treatment of women during pregnancy and breastfeeding, as active substances easily penetrate into milk and undergo a placental barrier. Contraindication is an increased sensitivity to any component of the drug. "Ranitidine" is not used in the process of treating children under 14 years.
In addition, this remedy is used to treat patients who are diagnosed with hepatic or renal failure, as well as acute porphyria and liver cirrhosis.
What side effects are possible during treatment?
Unfortunately, the active components of the drug affect almost all organ systems. Therefore, in some patients, the drug may be conjugate with some side reactions:
- Often there are headaches, drowsiness, increased anxiety, fast fatigue, dizziness, blurredness. In more serious cases, the medicine may lead to confusion, the development of depressive states, hallucinations.
- Disorders of the cardiovascular system, in particular, decrease in blood pressure, aplastic or hemolytic anemia, arrhythmia, tachycardia, thrombocytopenia, less often - bone marrow hypoplasia.
- Allergic reactions are often accompanied by the appearance of skin rashes and itching, increasing temperature, swelling, eritrem. Extremely rarely receive the drug leads to anaphylactic shock.
- The appearance of nausea and vomiting, abdominal pain. Extremely rare treatment leads to the development of pancreatitis and some forms of hepatitis.
When anyone appears side Effects It is worth stopping the medication and describe the symptoms of the doctor.
Additional information about the medicine
Before starting this medication, as a rule, a careful inspection is carried out, as it is extremely important to make sure there are no malignant tumors in the stomach and thin intestines. The fact is that the drug can mask the main symptoms of cancer.
Long-term treatment of patients with weakened immune system And the exhaustion of the body can lead to a bacterial affix of the tissues of the stomach.
Reception "Ranitidine" needs to be stopped gradually, a day after day reducing the dose. A sharp cancellation of the drug can provoke aggravation of peptic ulcer.
How is the drug "Ranitidine" with other drugs interact?
Quite often, therapy includes simultaneously using this anticance and antacids, which reduce the acidity in the stomach. In such cases, the break between the use of these drugs should be at least 1-2 hours.
The Ranitidine preparation makes it difficult to absorb ketoconazole, and also oppresses the exchange processes in the liver diazepam, metronidazole, lidocaine and some other drugs. By the way, smoking significantly reduces the effect of receiving this fund.
Gistamine H 2-receptor blocker. Anti-sized preparation
Active substance
Ranitidine (in the form of hydrochloride) (Ranitidine)
Release form, composition and packaging
Tablets covered with film shell Light orange color, round, double-screwed.
Auxiliary substances: microcrystalline cellulose, corn starch, collideon VA-64, silicon colloidal dioxide, magnesium stearate, hypimosellos, ethylcellulose, polyethylene glycol 6000, propylene glycol, sodium lauryl sulfate, titanium dioxide, dye solar sunset yellow.
10 pieces. - Blister (2) - cardboard boxes.
pharmachologic effect
Ranitidine blocks histamine H 2-receptors of parietal cells of the stomach mucosa, reduces basal and stimulated secretion of hydrochloric acid caused by irritation of baroreceptors, food load, the action of hormones and biogenic stimulants (gastrin, histamine, pentagastrin). Ranitidine reduces the volume of gastric juice and the content of hydrochloric acid in it, increases the pH of the contents of the stomach, which leads to a decrease in the activity of pepsin. After oral administration in therapeutic doses does not affect the level of prolactin. Inhibits microsomal enzymes.
The duration of action after one-time reception to 12 hours.
Pharmacokinetics
Quickly absorbed, food intake does not affect the degree of absorption. When taking inside, the bioavailability of ranitidine is about 50%. C max B is achieved in 2-3 hours after reception.
Binding with plasma proteins does not exceed 15%. Multimitably metabolized in the liver with the formation of desmethylranatidin and s-oxide of Ranitidine.
It has the effect of the first passing through the liver. The speed and degree of elimination are little dependent on the liver condition.
T 1/2 after intake - 2.5 hours, with CC 20-30 ml / min - 8-9 h. It is excreted mainly with urine (60-70%, unchanged - 35%), a slight amount - with a fee. Poor penetrates through the hematostephalic barrier. Penetrates the placenta. It stands out with breast milk (concentration in breast milk in women during lactation is higher than in plasma).
Indications
- Treatment and prevention of aggravations of ulcer of the stomach and duodenum;
Inhibits metabolism in the liver of the fenason, aminofenazone, diazepam, hexobarbital, proprakolol, diazepama, lidocaic, phenytoin, theophylline, aminoophylline, indirect anticoagulants, glypizid, buform, metronidazole, calcium antagonists.
Drugs, inhibiting bone marrow, increase the risk of neutropenia.
With the simultaneous use of C, sukralfat in high doses, it is possible to slow down the ranitidine absorption, so the break between the reception of these drugs should be at least 2 hours.
special instructions
Ranitidine treatment can mask the symptoms associated with the carcinoma of the stomach, so before starting treatment it is necessary to eliminate the presence of cancer-ulcers.
Ranitidine, as well as all H 2-gestamiblockers, is undesirable to abruptly cancel ("Ricochlet" syndrome).
With long-term treatment of weakened patients under stress conditions, bacterial gastric lesions are possible, followed by the spread of infection.
There is information that Ranitidine can cause sharp attacks of porphyria.
Blocators H 2 -Gistamine receptors should be taken 2 hours after receiving itraconazole or ketoconazole in order to avoid a significant reduction in their suction.
It can increase glutamatranspendase activity.
It may be the cause of a false-positive reaction to the sample on the protein in the urine.
Blocators H 2 -Gistamine receptors can counteract the effect of pentagastrine and histamine on the acidic function of the stomach, therefore, for 24 hours, the preceding test, it is not recommended to use N2-histamine-historical blockers.
Blocators H 2 -Gistamine receptors can suppress the skin reaction to histamine, thus, leading to false-positive results (before conducting diagnostic leather samples to detect an allergic skin reaction of an immediate type, the use of Blocators H 2 -Gistamine receptors is recommended to stop).
During treatment, the use of food, beverages and other drugs can be used, which can cause irritation of the stomach mucosa.
Use in pediatrics
Security and efficacy of ranitidine children under 12 Not installed.
Impact on the ability to driving vehicles and control mechanisms
During the treatment period, it is necessary to refrain from classes potentially hazardous species Activities requiring increased concentration of attention and speed of psychomotor reactions.
Result: positive feedback
12 +
Advantages: cheap, quickly helps, reduces pain, long effect, with low doses there are practically no side effects
Disadvantages: with long-term treatment there is addictive, strong side effects appear
When your ulcer is caused by increased acidity, you can not get rid of constant pain and discomfort so easily. I prescribed a gastroenterologist to drink Ranitidine, although when I saw his cost, it was in shock - a pill for 150 mg 20 pieces cost 30 rubles. Somehow I did not care when I bought, it hurts cheap Means. But I decided to try, if it does not help, to quit later. The preparation immediately pleases that it does not depend on eating food - drink, when you want, I love such pills. Take only 2 times on the tablet - in the morning and in the evening. It was written that the effect was already enough for 12 o'clock, well, I think they were alleged accurate. I will not say that the pain of the Namig disappeared - no. But after two hours, it began to fade, gradually so, leisurely, but in the end, it disappeared at all. I waited, waiting for the return of pain, but did not wait. Of course, the manufacturer little brought a little for a red sense - as long as 12 hours one tablet does not work, but I personally had enough for 8 hours - this is from the start of the action, and not from the moment of reception. But in fact, even when the action of the tablet ends, the pain does not return in full - such an effect from the first day. For such a price, it is very impressive, words are not. And there are no cracks after these pills at all, you can forget about discomfort. I also liked it that the stomach did not normally digest food, no problems arise - neither bloating, no meteorism, nor bumps, nor severity. The course of treatment has made a month. During this time, I forgot about the ulcers at all and decided to drink a different ulcer of this type and cannot be kept in the ultrasound. But here I encountered that gradually the efficacy of the drug decreases. Approximately a month and a half again began to return - light, but tangible. I had to take 3 tablets already, but after a couple of weeks and they helped weakly ...
Result: positive feedback
During the reception of the NSAID, it is indispensable - protects the stomach from ulcers
Advantages: inexpensive, affordable. It is convenient to take, eliminated heartburn and pain, protects the stomach from ulcers
Disadvantages: Not immediately after reception, not for continuous use - side effects
That always said that it is not worth spending money on expensive medicines - we are full of cheap and effective drugs. Ranitidine, I periodically support the body when the radiculitis is exacerbated and there is a handful of nonsteroidal anti-inflammatory drinks. They are strongly so the acidity of the stomach is raised, and what we have in the end - an ulcer! I and so because of the huge amount of aspirin, drunk in childhood, gastritis - often heartburn happens, stomach hurts, if you eat food, which the same acidity increases (fatty, oral food, etc.). It is worth a penny, I immediately buy 30 pieces, 70 rubles all, here and drink with a calm soul. Usually, if without this, I drink ipuprofen, all, write was gone - from the first day of the heartburn begins (which, if not provoked, is rarely) and in the stomach, the stomach occurs. And with Ranitidine, another thing is already two tablets grabs forget about the problems. It is better to drink in the morning, before eating, so that it has already begun to act - the drug does not immediately. Such in the instructions and write that at any time you can, when you drink the NSAIDs, you need to drink in advance, but I tried to drink with Ibuprofen, so I managed to have a heartburn. Yes, then she disappeared, but heartburn out of those things that do not feel better at all. And if you first drink, then eat and ibuprofen drink, heartburn simply will not even arise. So the week was actively sitting on the preparations, and there was no discomfort even. The drug does not simply eliminate the heart rate itself, it does it so that the acidity rising from nesteroids does not bring gastritis to ulcers. If you constantly take such drugs, Ranitidine is simply an indispensable thing - I calm down the lower back with confidence that the FGDS will once show that I have an ulcer ...
Result: positive feedback
One of the key components in the treatment of reflux-esophagitis
Advantages: price, efficiency
Disadvantages: side effects, it is impossible to abruptly cancel, not everywhere sold, it helps not in one day
From reflux-esophagitis itself, he does not cure, which the manufacturer does not promise, but it certainly helps to live normally. I always thought - just heartburn. It turned out that everything is serious - now I have an ulcer of the esophagus, that's what I brought. There are different preparations for treatment, but the doctor said that one of the best ranitidine is not only the secretion of gastric juice reduces (why the mucous meal ceases to be damaged), but still stands up - food is moving faster, therefore, there will be more from the stomach In the esophagus fall. I saw a month and a half already. Well, taking into account the cost of the medication is nothing terrible. In parallel, preparations were taken to cope with the gastric reflux themselves, so the disease eventually managed to cure. But for the period of treatment, Ranitidin became my Savior - after eating especially and during the day such a heartburn was that it seemed like - liquid fire in the area of \u200b\u200bthe esophagus, and even the pain was very strong - but also clearly, an ulcer, yes to her Even every time the acid falls, burning terrible. Here with Ranitidine the case went to the way, let and not immediately. Heartburn in the first days was the same frequent, but was not such an acidic acid, so it was smaller in the esophagus. Somewhere in a week-to-one and a half and the frequency decreased very much, the bumping is acid so at all disappeared - and before it was that tears from the eyes. For the month of this trouble, it was not at all - I had so much joy! Thanks to other drugs and ulcers, he began to heal, and the reflux himself became a rare none. There is one feature here - after the cancellation of the drug, if you took only it, the heartburn will return, because Ranitidine is just a temporary means that blocks the production of acid. It is a means that serves to prevent further damage to the mucous ...
Result: negative feedback
Definitely does not help with Zolinger-Ellison syndrome
Advantages: Cost
Disadvantages: no side effects, a lot of contraindications
For some reason, when I have a Zolinger-Ellison syndrome, we prescribed non-inhibitors of proton pump, and ranitidine - receptor blocker. Yes, they both reduce acid production, but act differently. I will only talk about my illness, I don't know how there is a case with simple ulcers and helps whether, but with my diagnosis - no. In the abdomen, heartburn and terrible belching, I was at the beginning of an ulcer, which I had, but when "Acid" diarrhea went, ran to another doctor, there is a survey and a diagnosis - a tumor. Do not immediately make the operation, first they will try to treat. Ranitidine showed himself with not so good side - he is weak for such a disease. Reducing the production of hydrochloric acid with this disease is easy to notice not only in the absence of heartburn and belching, everything is clear here in diarrhea, in which there is always an excess acid. So here. Two weeks of reception, the frequency of such diarrhea fell slightly - from 5 times to 3 per day. Heartburn has become a little less strong, belching is slightly less acidic, but they were just the same frequent. Tried a dose to increase, but 500 mg saw. But first there was no effect, and then a completely unexpected side effect appeared - heard about such a thing as Porphyria? It is when from the sun on the skin of the ulcers and spots appear. And I just drank in the summer, and now you - on the ear, the yazelka appeared, on the face - small bright red spots, and the skin was sick strong. It turned out, this is also a side effect. The most frequently added to it, especially if you apply high doses for a long time (long - more than 2 weeks in my case) - and itching throughout the body, and drowsiness, and mutton constantly, in the mouth is always dry, as in Sakhar, yes The chest is heavy and painful becomes due to the ability of the drug hormones to command. There is a month to be treated, without a sense ...
Result: neutral feedback
There is not enough effect for a long time, and even the pancreatitis caused
Advantages: low cost
Disadvantages: Effect long to wait, it quickly passes, the drug does not treat, side effects, spoils tests
To whom, I have no progress from this suspiciously cheap tool, but problems were just. In case of ulcers, it was prescribed very often, I was gastritis, and we were prescribed just that it does not turn into an ulceance due to high acidity in the stomach. I bought a big pack, began to drink. The effect to wait like the coming, I thought I will drink and there will be no heartburn, but not to you - I drank when I eaten, heartburn was still, the stomach was sick. Fed to eat drink. So it seems better, but still, it turns out that the effect is starting and heartburn still happens. Well, long to wait for him - this is another one, so it also goes quickly. I have heartburn and then when we do not eat, and just get or even in an incomprehensible reason - 5-6 times per day. So, less rare the attacks of steel, but not much - 3-4 times the stomach "burned", because if when taking a pill after eating heartburn and did not happen, after a couple of hours, she again returned, so no longer - well, however Here two pills on the day do something? And no more drinking, I tried to have a risk and risk - so the stomach fell ill and it became sick, that the nightmare is simple. For the night of drinking, too, useless - heartburn It is strong at night, because you are lying, and since the drug acts just a couple of hours, what to drink it - you still wake up. As stopped drinking, so the heartburn returned, as if I didn't drink anything at all - even a couple of days, at least a weak effect was not preserved. Yes, he still has a lot of side effects - probably, who has some body weaker. According to that and beats, because I had a pancreatic unhealthy, but I walked pancreatitis. I think that, I put mashed, and after a couple of weeks of reception already in the left hypochondrium, it was so sick and twisted so that she was plafhmy ...
Do not seduce on low price. It is quite explained by the presence of a huge number of side effects. The most dangerous of them relate to women - our hormonal balance. I would never have thought that the pills to reduce the production of acid in the stomach may have such serious consequences to lead the ranitidine ulcers. In fact, ulcers only do not cure if it is bacteria Helicobacter Pilori is caused, but without him - too, because antibacterial drugs They will not work in full force when around the aggressive environment. I was treated with 3 drugs: 2 antibiotics and ranitidine, which was the cheapest of them. 2 weeks were treated, and then the drug was prescribed for another 2 months to drink, so that the wound itself - ulcer - could calmly be heard after the bacterium extermination A couple of days after the start of use, the stomach stopped to whine, and the gases became much smaller. Couples tablets per day for such an effect enough with interest, as not to start them to admire? As long as he was treated, it was generally comfortable to live. And in general, at first I also praised the drug and scolded the doctors who advised me to sit on expensive medicines. And after a month, I got a shot menstrual cycle. Monthly were scarce, scary painful, and still chest sucked as never before. I tied it with stress, hormones, and that's it. Another month passed, during which my chest had a stronger and stronger from me, and the monthly did not happen at that month. I went to the gynecologist, there are tests, ultrasound. When I learned the results, I almost fell - I had prolactin over 2000! And the ultrasound killed so much - fibrous-cystic mastopathy, it just because of this level prolactin and appeared ...
