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Before using PENTALGIN-N, you should consult your doctor. These instructions for use are for informational purposes only. For more complete information please refer to the manufacturer's annotation.
03.010 (Combined analgesic-antipyretic)
Tablets of white or white color with a yellowish or creamy shade, flat-cylindrical, with the abbreviated name of the drug "PENT-N" embossed on one side.
Excipients: potato starch, low molecular weight polyvinylpyrrolidone (povidone), sodium citrate, magnesium stearate.
10 pieces. - contour cell packaging (1) - cardboard packs.
The combined preparation has analgesic, antipyretic and anti-inflammatory effects.
Metamizole sodium is an analgesic-antipyretic, a pyrazolone derivative. Has a pronounced analgesic effect.
Naproxen is an NSAID that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of COX, which regulates the synthesis of prostaglandins.
Caffeine causes dilation of blood vessels in skeletal muscles, brain, heart, and kidneys. Increases mental and physical performance, helps to eliminate fatigue and drowsiness. Increases the permeability of histohematogenous barriers and increases the bioavailability of non-opioid analgesics, thereby contributing to the enhancement therapeutic effect.
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Codeine stimulates opioid receptors in various parts of the central nervous system, which leads to the activation of the antinociceptive system and changes in the emotional perception of pain.
Phenobarbital and codeine increase the analgesic effect of sodium and naproxen.
The components of the drug are well absorbed in the gastrointestinal tract.
Metamizole sodium
In the intestinal wall, it is hydrolyzed to form an active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The binding of the active metabolite to proteins is 50-60%. Metabolites are excreted by the kidneys and excreted in breast milk.
Naproxen
Bioavailability is 95%. Binds to blood proteins. T1 / 2 - 12-15 hours. It is excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small quantities in the bile.
It is well absorbed in the intestines. T1 / 2 - 5 hours (sometimes up to 10 hours). It is excreted mainly by the kidneys in the form of metabolites, about 10% - unchanged.
Slightly binds to plasma proteins. Undergoes biotransformation in the liver (10% is converted to morphine by demethylation). It is excreted by the kidneys (5-15% - unchanged).
Phenobarbital
Bioavailability is 80%. Plasma protein binding - 50%. Penetrates well through the placental barrier. Biotransformed in the liver. The main metabolite has no pharmacological activity. It is excreted by the kidneys, incl. 20-25% - unchanged.
The drug is prescribed 1 tab. 1-3 times / day Maximum daily dose- 4 tab.
The drug should not be taken for more than 5 days as a pain reliever and more than 3 days as an antipyretic drug without a doctor's prescription.
Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, heart rhythm disturbances, delirium, weakness, respiratory depression.
Treatment: induction of vomiting, gastric lavage through a tube, administration of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.
The simultaneous use of the drug with other non-opioid analgesics can lead to increased toxic effects.
Tricyclic antidepressants, oral contraceptives, allopurinol increase the toxicity of metamizole sodium, which is part of the drug.
Barbiturates, phenylbutazone and other inducers of liver microsomal enzymes weaken the effect of sodium metamizole.
The simultaneous use of metamizole sodium with cyclosporine reduces the level of the latter in the blood.
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Sedatives and tranquilizers enhance the analgesic effect of the drug.
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
If necessary, prescribing the drug during lactation breast-feeding should stop.
From the side digestive system: epigastric pain, nausea, vomiting, constipation; with long-term use in high doses - liver dysfunction.
From the hematopoietic system: rarely - inhibition of hematopoiesis (leukopenia, granulocytopenia, agranulocytosis).
From the side of the central nervous system: dizziness, drowsiness.
On the part of the cardiovascular system: palpitations.
From the urinary system: with prolonged use in high doses - impaired renal function.
Allergic reactions: skin rash, itching, urticaria.
The drug should be stored out of the reach of children, in a dry, dark place at a temperature not exceeding 25 ° C. Shelf life is 3 years.
The drug should be used with caution when arterial hypertension easy and medium gravity, peptic ulcer stomach and / or duodenum in remission, as well as in elderly patients.
With prolonged (more than 5 days) administration of the drug, it is necessary to monitor the peripheral blood picture and liver function indicators.
Taking the drug Pentalgin®-N can make it difficult to establish a diagnosis in acute abdominal pain syndrome.
In patients with atopic bronchial asthma and hay fever, the risk of developing hypersensitivity reactions while taking Pentalgin®-N is increased.
While using the drug, it is possible to change the results of doping control in athletes.
Influence on the ability to drive vehicles and use mechanisms
When taking the drug Pentalgin®-N, you should refrain from driving vehicles and practicing potentially dangerous species activities requiring increased concentration of attention and speed of psychomotor reactions.
The drug is contraindicated for use in severe renal impairment.
The drug is contraindicated for use in severe liver dysfunction.
The drug is approved for use as a non-prescription drug.
tab .: 10 pcs. LS-002271 (2017-06-10 - 0000-00-00)
Film-coated tablets
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The combined preparation has analgesic, antipyretic and anti-inflammatory effects.
Drotaverine - has a myotropic antispasmodic effect due to inhibition of phosphodiesterase IV, acts on smooth muscles in the gastrointestinal tract, biliary tract, genitourinary and vascular systems.
Pheniramine is a blocker of H1-histamine receptors. It has an antispasmodic and mild sedative effect, reduces exudation phenomena, and also enhances the analgesic effect of paracetamol and naproxen.
Paracetamol is a non-narcotic analgesic that has antipyretic and analgesic effects due to the blockade of cyclooxygenase in the central nervous system and the effect on the centers of pain and thermoregulation.
Naproxen is a non-steroidal anti-inflammatory drug that has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of cyclooxygenase, which regulates the synthesis of prostaglandins.
Caffeine - causes dilation of blood vessels in skeletal muscles, heart, kidneys; increases mental and physical performance, helps to eliminate fatigue and drowsiness; increases the permeability of histohematogenous barriers and increases the bioavailability of non-narcotic analgesics, thereby enhancing the therapeutic effect. Has a tonic effect on the vessels of the brain.
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Artrozilene capsules 320 mg, 10 pcs.
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Gel
Carefully the drug should be used for mild and moderate arterial hypertension, gastric ulcer and / or duodenal ulcer in remission, as well as in elderly patients.
The use of the drug during pregnancy and lactation (breastfeeding) is contraindicated.
Simultaneous use should be avoided Pentalgina with other drugs containing paracetamol and / or other non-steroidal anti-inflammatory drugs, as well as with drugs to relieve the symptoms of "cold", flu and nasal congestion.
When using the drug for more than 5-7 days, it is necessary to monitor the parameters of peripheral blood and functional state liver.
Paracetamol distorts the results of laboratory tests of the content of glucose and uric acid in the blood plasma.
If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study. It should be borne in mind that naproxen increases bleeding time.
Effect of caffeine on central nervous system depends on the type of the nervous system and can manifest itself as excitement and inhibition of higher nervous activity.
During the period of treatment, you should not consume alcoholic beverages.
In some cases, it is possible to reduce the concentration of attention and the speed of psychomotor reactions, therefore, during the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.
1 tablet contains: paracetamol 325 mg, naproxen 100 mg, caffeine 50 mg, drotaverine hydrochloride - 40 mg, pheniramine maleate - 10 mg;
Excipients: microcrystalline cellulose, potato starch, croscarmellose sodium, hyprolose (hydroxypropyl cellulose (clotsel EF)), citric acid monohydrate, butyl hydroxytoluene (E 321), magnesium stearate, talc, quinoline yellow dye (E 104) (indigo carmine).
Pentalgin taken orally 1 tablet 1-3 times a day.
The maximum daily dose is 4 tablets.
The duration of treatment is no more than 3 days as an antipyretic agent and no more than 5 days as an anesthetic.
Continuation of treatment with the drug is possible only after consulting a doctor.
Allergic reactions: skin rash, itching, urticaria, angioedema;
From the side of the hematopoietic organs: thrombocytopenia, leukopenia, agranulocytosis, anemia, methemoglobinemia;
From the nervous system: agitation, anxiety, increased reflexes, tremors, headache, sleep disturbances, dizziness, decreased concentration;
On the part of the cardiovascular system: palpitations, arrhythmias, increased blood pressure;
From the digestive system: erosive and ulcerative lesions gastrointestinal tract, nausea, vomiting, epigastric discomfort, abdominal pain, constipation, liver dysfunction;
From the urinary system: impaired renal function;
From the senses: hearing loss, tinnitus, increased intraocular pressure in patients with angle-closure glaucoma;
Others: dermatitis, tachypnea (rapid breathing).
With the simultaneous use of agents that have a depressing effect on the central nervous system (including sedatives and tranquilizers), an increase in the severity of the sedative effect and the depressing effect on the respiratory center is likely. Enhances the effect of ethanol on the psychomotor reaction.
Metamizole sodium reduces the concentration of cyclosporine. Metamizole sodium, displacing oral hypoglycemic drugs from the connection with protein, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity.
Tricyclic antidepressants, oral contraceptives, allopurinol disrupt the metabolism of metamizole in the liver and increase its toxicity.
The simultaneous use of the drug with other non-narcotic analgesics can lead to increased toxic effects.
Barbiturates, phenylbutazone and other inducers of liver microsomal enzymes weaken the effect of metamizole.
Check the interaction of other drugs with "Pentalgin"Symptoms: nausea, vomiting, gastralgia, drowsiness, tachycardia, heart rhythm disturbances, delirium, weakness, respiratory depression.
Treatment: induction of vomiting, gastric lavage through a tube, the appointment of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.
Store in a dry, dark place at a temperature not exceeding 25 ° C.
Does not belong to VED
Does not contain narcotic drugs, psychotropic substances and their precursors
Pentalgin-N: instructions for use and reviews
Latin name: Pentalginum-N
ATX code: N02BB72
Active substance: codeine + caffeine + metamizole sodium + naproxen + phenobarbital (codeine + caffeine + metamizole sodium + naproxen + phenobarbital)
Producer: Pharmstandard-Tomskkhimfarm, JSC (Russia)
Description and photo update: 22.11.2018
Pentalgin-N - combination drug with analgesic, antipyretic and anti-inflammatory effects.
Dosage form Pentalgin-N - tablets: flat-cylindrical, from white to white with a cream or yellowish tint, with the abbreviated name of the drug "PENT-N" printed on one side (in a cell or non-cell contour packaging 10 pcs., In a cardboard box 1 or 2 packs).
Composition of one tablet:
IN composition of Pentalgin-N includes active substances with analgesic, antispasmodic, antipyretic, anti-inflammatory and sedative effect.
Metamizole sodium is a pyrazolone derivative. It has analgesic and antipyretic effects.
Naproxen, being a non-steroidal anti-inflammatory agent, has anti-inflammatory, analgesic and antipyretic properties, which are due to non-selective inhibition of the activity of the enzyme cyclooxygenase, which is responsible for the production of prostaglandins from arachidonic acid.
Caffeine helps to dilate the blood vessels of skeletal muscle tissue, heart, brain, kidneys, increase physical and mental performance, reduce fatigue and drowsiness. By increasing the permeability of histohematogenous barriers and increasing the bioavailability of non-narcotic analgesics, caffeine leads to an increase in their therapeutic effect.
Codeine has the property of stimulating opioid receptors in various parts of the central nervous system, leading to the activation of the antinociceptive system and an improvement in the perception of pain at the emotional level.
Phenobarbital and codeine increase the analgesic effect of metamizole sodium and naproxen.
The active substances of the drug are well absorbed in the gastrointestinal tract.
Some pharmacokinetic characteristics of the active ingredients of Pentalgin-N:
Absolute:
Relative (use of the drug requires caution):
Pentalgin-N tablets are taken orally.
In case of an overdose of Pentalgin-N, the development of following symptoms: nausea, vomiting, drowsiness, weakness, gastralgia, disturbances heart rate, tachycardia, delirium, respiratory depression.
Treatment in case of an overdose consists in the induction of vomiting, gastric lavage through a tube, the use of adsorbents (for example, activated carbon), symptomatic therapy aimed at maintaining the functioning of vital organs.
While taking Pentalgin-N, it may be difficult to establish a diagnosis in case of acute abdominal pain syndrome.
In patients with hay fever and atopic bronchial asthma, the risk of developing hypersensitivity reactions increases with the use of the drug.
In the case of prolonged (more than five days) administration of Pentalgin-N, it is necessary to monitor liver function indicators and the picture of peripheral blood.
During the period of use of the drug, the results of doping control in athletes may change.
Since Pentalgin-N can cause such adverse reactions like dizziness and drowsiness, while taking the pills should refrain from driving Vehicle and performing potentially hazardous activities that require increased concentration of attention and quick psychomotor reactions.
According to the instructions, Pentalgin-N is contraindicated for use by pregnant and breastfeeding women.
If it is necessary to use the drug during the lactation period, breastfeeding should be discontinued.
It is prohibited to prescribe Pentalgin-N to children under 12 years of age.
Take the drug in patients with severe renal failure contraindicated.
In case of severe violations of liver function, it is not recommended to prescribe Pentalgin-N.
Elderly patients should be careful when taking the drug.
The use of Pentalgin-N simultaneously with some drugs can lead to the development of the following effects:
Keep out of the reach of children.
Shelf life is 3 years.
Pentalgin is a combined drug that has an effective anti-inflammatory and analgesic effect. The therapeutic effect of the drug is due to the five main active components that make up its composition. Instructions for the use of Pentalgin tablets describe it in detail pharmacological properties and effects on the body. According to her, the drug has the ability to inhibit the synthesis of prostaglandins by blocking in central nervous system an enzyme such as cyclooxygenase.
Pentalgin is a highly effective remedy for the elimination of severe pain of various etiological nature. This non-steroidal and non-narcotic drug is able to cope with severe pain syndrome, as well as to have a high anti-inflammatory and antipyretic effect. I.e, this drug very quickly eliminates pain, various spasms, lowers the temperature and eliminates the focus of inflammation.
The medicine has analgesic, antispasmodic, psychostimulating properties and effectively blocks H1-histamine receptors. The action of the drug is provided by the following medicinal substances included in the composition:
Effectively eliminates spasms of any nature, has a beneficial effect on smooth muscles, biliary tract, genitourinary and vascular system... The substance has a pronounced antispasmodic myotropic effect.
It is a non-narcotic analgesic that effectively lowers heat and relieves pain. Its analgesic and antipyretic effect is due to the blockade of certain enzymes of the central nervous system, which leads to an effective effect on pain centers and regulates body temperature.
Anti-inflammatory non-steroidal component that quickly eliminates inflammatory process, has a pain relieving effect and can also reduce fever. The action of the substance is associated with the suppression of the enzyme cyclooxygenase, which regulates the synthesis of prostaglandins. Naproxen actively prevents the development of inflammation and pain.
Expands blood vessels tissues and muscles, has a beneficial effect on the kidneys and heart, eliminates fatigue, drowsiness, increases physical and mental performance. Caffeine enhances the bioavailability and effect of analgesics that are included in Pentalgin. It increases the permeability of barriers and helps to increase the therapeutic effect of the drug. Caffeine has a tonic effect on the blood vessels of the brain.
It is a blocker of histamine receptors. Effectively relieves spasms and pains of various types, enhances the analgesic effect of paracetamol and naproxen.
What does Pentalgin help from? The tool has a very wide range application. The drug is effective for headaches, rheumatic pains, pain after surgery. The main indications for the use of the drug:
Also, these drugs are often prescribed:
The drug is a tablet. The maximum allowable dose of the drug is 4 tablets per day. It is important to know that long-term use of Pentalgin tablets can cause drug addiction. It is not recommended to use the drug in treatment for more than seven days. In case of such a need, it is required to monitor the functioning of the liver and kidneys, as well as the composition of the blood.
Pentalgin should not be used while carrying a baby and while breastfeeding. Also, the drug is not used in the treatment of children under 12 years of age. The main contraindications:
Pentalgin must be taken with caution in elderly people with epilepsy.
The drug Pentalgin N contains sodium metamizole, phenobarbital, codeine, naproxen and caffeine. The medicine is available in tablets, in a blister contour packaging (10 pieces). Phenobarbital provides a sedative effect, calms the nervous system. Codeine blocks certain receptors and effectively relieves pain. The drug is a non-narcotic analgesic. It has an analgesic effect and effectively copes with pain in various diseases.
Pentalgin N is used to eliminate any pain and in febrile conditions. It is used after operations, for colds, neuralgia, myalgia, radiculitis and other diseases. The drug is very effective in relieving toothache, muscle pain and quickly eliminating migraines.
The medication is contraindicated for:
There is also such a medicinal variety as a drug Pentalgin icn... In its composition, this drug contains paracetamol, caffeine, phenobarbital, codeine phosphate, sodium metamizole. It is a combined medication that has anti-inflammatory, analgesic and antipyretic effects. The drug effectively blocks pain by acting on the centers of inflammation. Reduces the motility of the intestinal sphincters, relaxes smooth muscles, eliminates spasms.
The medicine is indicated to eliminate pain syndrome of any etiology, it is used for headaches, colds, rheumatism, after surgery. Also, the remedy perfectly eliminates toothache and muscle pain. The drug should not be used for a long time and uncontrollably.
Contraindications:
The drug is very well tolerated by the body and rarely causes side effects... When taking the drug, in rare cases, manifestations such as:
In case of an overdose of the drug, vomiting, nausea, weakness, a decrease in heart rate and blood pressure may occur. Also, in case of an overdose, an allergic reaction manifests itself, suppression of the central nervous system.
Bearing a fetus requires a pregnant woman to pay special attention to her health. Any intake of medications can cause the risk of developing various pathologies and developmental disabilities in the unborn child. A pregnant woman needs to be as careful as possible when treating with medications. Any desire to take medications should be agreed with a gynecologist who knows the peculiarities of the course of pregnancy.
The drug Pentalgin and its varieties Pentalgin N, Pentalgin icn cannot be used during pregnancy! The instruction for the drug from the manufacturers of the drug prohibits its use during the period of bearing a child at any stage of pregnancy. It is better for the mother-to-be to use other, less dangerous drugs... Today, the pharmaceutical market offers pregnant women a large selection of various safe homeopathic remedies that are allowed to be used when carrying a fetus.
Also, Pentalgin is not used during the period of breastfeeding. The active substances that are part of the drug are very quickly absorbed into the bloodstream and penetrate into breast milk. For treatment with Pentalgin, it is better to transfer the child to artificial feeding or refuse to take this medication.
Taking the drug is allowed after 12 years. Before the indicated age, Pentalgin cannot be used in the treatment of children according to the manufacturer's instructions. medication... For children over 12 years old, it is undesirable to use single dose in the form of an acceptable two tablets. Otherwise, the drug will have an extremely negative effect on children's organism... You should also limit your treatment to two to three tablets per day. The instruction allows children to be given 1 tablet of Pentalgin three times a day.
With the appearance of weakness, nausea, allergies, vomiting, dizziness, tinnitus and other negative side effects taking the drug must be stopped and a doctor must be consulted.
The drug is a very strong pain reliever, so it is often used to relieve various pains after surgery. Also, the drug can be effectively used after tooth extraction. It is undesirable to take two tablets at a time. The components of the drug are focused on fast action, so you should wait for the pain to subside.
This drug is widely used during the recovery period after severe operations. You should know that a prescription for Pentalgin without codeine is not required to purchase the drug in a pharmacy. If the type of drug does not include codeine in its composition, the drug can be freely purchased at pharmacies.
The high efficiency of Pentalgin in eliminating pain after surgery is due to the active properties of the components of the drug. In the body, paracetamol binds to plasma proteins and steadily blocks the development of prostaglandins. The medicinal substances of the drug act directly on the receptors that cause pain.
Phenobarbital, which is part of the drug, has a relaxing effect on the nervous system, soothes nerve receptors and reduces excitability. The complex effect of all the components of Pentalgin allows you to quickly and steadily eliminate stabbing, cutting, pulling pains after surgery.
The pharmaceutical market today offers a wide variety of pain relievers. Pentalgin has its advantages over other anesthetic drugs, but sometimes it becomes necessary to replace it with similar drugs. There are cheaper analogues of Pentalgin, which have a similar composition and effect. When choosing a drug from a group of analogs, it is important to consult with your doctor in advance. Perhaps due to the characteristics of the body similar drug will not work.
The main analogues of Pentalgin:
In a retail pharmacy, the price of a drug may vary. Approximate cost:
Average price of peers:
/ Pentalgin-N
Dropped in pharmacies
without recipe
Manufacturer
Pharmstandard-Leksredstva, Russia
Pharmacological group
Analgesic
Active substance
metamizole sodium, codeine, phenobarbital, caffeine, naproxen (combination drug)
"Pentalgin-N" - effective drug, which has a strong analgesic, anti-inflammatory effect. Relieves pain syndrome different etiology... It is especially effective for severe pain, including postoperative pain. From pharmacies it is dispensed by prescription, is taken only according to indications, for an appointment, you must contact your doctor.
Tempalgin is a combined analgesic (pain reliever) agent with antipyretic and sedative effects. It is used for febrile conditions due to high body temperature, for toothache and headache, pain relief after surgery. When using Tempalgin, fear, anxiety, excitement go away, and arterial pressure... Tempalgin is a fast-acting drug that has a sedative effect in half an hour, and an anesthetic effect in an hour. It cannot be applied by the course, but should be immediately canceled as soon as the opportunity arises.
Everyone has their own pain threshold and sometimes it is simply impossible to tolerate pain, especially toothache and headache. Tempalgin will help relieve moderate pain and dull acute toothache. It contains analgesic and sedative substances, so the pain will go away within 10-15 minutes after taking the pill, and the analgesic effect will last for several hours. Take the pill after meals with plenty of water. Dosage for adults - 1-2 tablets three times a day (no more than 6 tablets per day). Children over the age of 14 can be given 1 tablet twice a day. Do not use Tempalgin for more than 5 days!
Pentalgin-N is available in the form of tablets of white or white color with a yellowish or creamy shade, flat-cylindrical, with the abbreviated name of the drug PENT-N embossed on one side. One tablet contains:
Pentalgin-N tablets can be purchased in 10 pieces in a blister strip packaging. 1 or 2 blister packs together with instructions for use in a cardboard box.
Pentalgin-N is a combined drug that has analgesic, anti-inflammatory and antipyretic effects. Naproxen and metamizole sodium have analgesic and anti-inflammatory effects. Codeine stimulates opioid receptors in various parts of the central nervous system, which leads to the activation of the antinociceptive system and changes in the emotional perception of pain. Codeine and phenobarbital increase the analgesic effect of metamizole sodium and naproxen. Caffeine dilates the vessels of skeletal muscles, kidneys, heart, and brain.
Pentalgin-N increases mental and physical performance, eliminates fatigue and drowsiness; increases the permeability of histohematogenous barriers and increases the bioavailability of non-opioid analgesics, thereby enhancing the therapeutic effect. The drug is biotransformed in the liver, excreted by the kidneys, and penetrates the placental barrier.
Pentalgin-N tablets are indicated for use in mild and moderate pain syndrome of various origins, including pain in joints, muscles, sciatica, menstrual pain, neuralgia, toothache and headaches (including migraine). They also help with post-traumatic and postoperative pain syndrome.
Pentalgin-N is contraindicated for use in the following cases:
Take with caution with arterial hypertension of mild and moderate severity, in old age. A doctor's consultation is required.
Application of Pentalgin N during pregnancy and breastfeeding: the drug is contraindicated during pregnancy and lactation, penetrates into breast milk.
Pentalgin-N is taken orally. The drug is taken 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets. The drug is not recommended to be used for more than five days as an analgesic and for more than three days as an antipyretic without the appointment and supervision of a doctor.
Allergic reactions, including Steven-Johnson syndrome, Lyell; bronchospasm.
It causes addiction and drug dependence with prolonged use.
Symptoms of drug overdose: nausea, vomiting, gastralgia, drowsiness, tachycardia, heart rhythm disturbances, respiratory depression, delirium, weakness.
Overdose treatment: induction of vomiting, gastric lavage through a tube, prescription of adsorbents (activated carbon), symptomatic therapy aimed at maintaining vital functions.
The simultaneous use of Pentalgin N with other non-opioid analgesics can lead to increased toxic effects. Sedatives and tranquilizers enhance the analgesic effect of the drug. The simultaneous use of metamizole with cyclosporine reduces the level of the latter in the blood. Barbiturates, phenylbutazone and other inducers of liver microsomal enzymes weaken the effects of sodium metamizole. Tricyclic antidepressants, oral contraceptives, allopurinol increase the toxicity of metamizole sodium included in the drug.
During treatment, you should stop drinking alcohol. With prolonged use (more than 5 days), it is necessary to monitor the peripheral blood picture and liver function indicators. Against the background of the use of the drug, it is possible to change the results of doping control of athletes.
In some cases, it is possible to reduce the concentration of attention and the speed of psychomotor reactions, therefore, during the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions. Taking the drug can make it difficult to establish a diagnosis in acute abdominal pain syndrome.
Pentalgin-N is dispensed strictly according to the prescription. Form 148-1 / y-88. There is a dispensing rate for 1 prescription, taking into account an indivisible package of 20 tablets.
In a dry place, at a temperature not exceeding 25 C. Keep out of the reach of children! Do not use the drug after the expiry date indicated on the package.
You can replace Pentalgin-N with the following analog drugs: