Bacterial infections cannot be cured without the use of antibiotics. To provide minimal harm to the body and avoid the development of adverse symptoms, doctors prescribe preparations from the penicillin group. Flexin is considered convenient in the reception, because it is sold in the form of dispersible tablets.

Other names and classification

Flemoxin Solutab, Amoxicillin, Flexin 500. Antibacterial drug from penicillin category.

International non-proprietary title

Amoxicillin.

Trade names

Flexin SOLUTAB.

Registration number

LS-001852-300517.

ATX

Composition and dosage forms

The antibiotic is offered to buyers only in dispersible tablets. They have a whitish or slightly yellowish tint and oval shape. Each tablet has a pharmacological company logo with a digital image "234" and a dividing strip.

Added additional ingredients:

• dispersible pulp;
• microcrystalline cellulose;
• crospovidon;
• vanillin;
• mandarine flavoring;
• lemon flavoring;
• saccharin;
• magnesium stearate.

5 tablets are placed in one contour cell. Total number - 20 pcs.

Pharmacological group

Antimicrobial medication of semi-synthetic origin from the penicillin group.

pharmachologic effect

The medication is characterized by a wide range of action. It is a 4-hydroxyl analog of ampicillin. Distinguished by a bactericidal property.

It shows activity in relation to aerobic gram-positive bacteria in the form of staphylococci and streptococci. Effectively struggles with aerobic gram-negative microbes in the form of Neisseria Gonorrhoeae and Meningitidis, Eshehiriyia, Shigella, Salmonella, Klebsiella.

The acting substance is not susceptible microorganisms producing penicillinase.
In aggregate with metronidazole is able to eliminate activities Helicobacter pylori..

When using a tablet inside the active component is instantly absorbed into the intestinal walls. It is not subjected to destroying in an acidic stomach. In the blood is found in 1-2 hours. Equally applies to the tissues and body fluids. The greatest concentration is observed in the liver. It is displayed along with urinus unchanged.

From what is prescribed Flexin 500

The annotation says that antimicrobial medicine is used to treat patients with development:

• angina, Farriagita;
• pneumonia, bronchitis in chronic form;
• sinusitis and sinusitis of acute and chronic character;
• acute inflammatory process in the middle part of the aisle;
• pyelonephritis, pyelitis, cystitis, urethritis, cervicitis, endometritis;
• grinding inflammation, dermatosis, secondary damage to the skin and soft tissue structures;
• angocholite, peritonitis, abdominal typhoid, cholecystitis, salmonellosis, dysentery.

It can be appointed as prevention of complications after suffering heavy pathologies. Helps with purulent wounds.

In pediatrics

Flexin Soluteab refers to one of the frequently appointed funds. In pediatrics, the antibiotic is used when infected with bacteria respiratory tract. Based on numerous experience, it was proved that the tool allows you to quickly achieve a positive result in the occurrence of sinusitis, acute unmarginous otitis, chronic bronchitis, bronchopneumonia, tonsillitis and angina.

How to take Flexin 500

The drug with a dose of 500 mg is used to treat adolescents and adults with weight more than 40 kg. In a facilitated variety of disease, 250-500 mg is prescribed. Under development heavy Current The dose is raised to 1 g per day.

How many times a day

How many days to drink

The duration of therapeutic course depends on the flow and severity of the disease. On average ranges from 1 to 1.5 weeks. In complicated cases, 14 days continues.

How to give children

Flexin can be prescribed to children. Then the tablet is divided into several techniques:

1. Children from 5 to 10 years have shown 250 mg.
2. A child from 2 to 5 years is given by 125 mg.
3. For children under 2 years old, the dose is calculated based on body weight according to the following formula: 1 kg of weight goes 20 mg per day.

Before use, the tablet is dissolved in a spoonful of warm water until the formation of a homogeneous suspension.

Dosage

Selection of dose depends on the age of the patient and the variety of the disease.

With prostatitis

Amoxicillin is often used to treat prostatitis in men. Patients are appointed 2 g per day. The daily dosage is divided into 2-3 receptions at an equal period of time. Treatment lasts for 14 days.

With angina

Angina is characterized by the defeat of the sky almonds. The medication applies only when pathology is caused by amoxicillin-sensitive bacteria. Adult dosage is 500-700 mg. Multiplicity of application - twice a day. For the treatment of children, a dose of 125-250 mg is used, just to take a medication 3 times a day. The course of treatment lasts 10 days. This is necessary in order to avoid complications on other organs.

With hyimorite

Treatment of sinusitis with antimicrobial agents is carried out only if the disease is caused by bacteria and is not allergic. In acute flow, the patient is assigned to 1 g per day. The dosage is separated by 2 receptions at the interval at 12 o'clock. Treatment lasts 7 days.
For chronic flow The daily dosage is 1.5 g. Take the medicine. It is necessary to 1.5-2 weeks.

With bronchitis

With this type of disease, the dosage increases depending on age. Adults are appointed at 750 mg three times a day. IN childhood The amount of the preparation is determined by the following formula: 1 kg of weight accounts for 60 mg per day. The duration of therapeutic course is 10 days.

Special guidelines when using Flexin 500

It is possible to develop a cross-reaction to penicillins and cephalosporins.

When developing a pseudommable colitis and rack diarrhea, the drug should be canceled.

If patients have lympholoicosis or infectious mononucleosis, the reception of the medication leads to an increase in the risk of a non-allergic examination.

After use, the composition of the intestine microflora is normal with bifidobacteria.

During pregnancy and breastfeeding

The medicine can be appointed future mothers after 12-13 weeks of pregnancy. But the doctor must appreciate the benefit and risk to the fetus.

It may be necessary to stop lactation and the translation of the child to artificial feeding.

When violations of the liver function

Carefully used to treat patients with liver diseases. It is not recommended to take with liver failure.

With violations of the kidney function

When the kidney function is impaired, the dosage and break between the receptions should be adjusted depending on the clearance of creatinine. It is forbidden to drink pills when hard renal failure.

Side effects Flexin 500

During drug therapy, a patient can manifest a side symptoms in the form of:

• urticaria, exudative erythema, itching and redness, rash on skin;
• nausea, changes in taste, diarrhea, vomiting urges;
• neutropenia, agranulocytosis.

With prolonged use of drugs, dizziness, ataxia, confusion of consciousness, convulsions are observed.

In complicated cases, anaphylactic shock arise, swelling, feverish state, superinfection, the development of hepatic insufficiency.

Impact on the ability to control vehicles and other mechanisms

Does not affect work nervous system. Therefore, the patient can continue to drive a car and work with complex mechanisms.

Contraindications

The medication is prohibited from some diseases in the form:

• infectious mononucleosis;
• lympholecosis;
• heavy infections digestive tract;
• respiratory viral infections;
• an allergic diatese in history;
• bronchial asthma;
• hay fever;
• strong susceptibility to basic and auxiliary substances.

Caution is prescribed with renal or hepatic pathologies, as well as in heart disease.

Overdose

In case of non-compliance with the dose, symptoms of overdose in the form of nausea, vomiting, disorders appear water salt balance. In such situations, the doctor gives the following appointments: washing the stomach, reception of sorbents and salt laxatives, adjusting the balance of water and electrolytes.

Interaction and compatibility

The effect of oral contraceptives is reduced when taking an antibiotic. During the therapy, it is recommended to use additional methods protection.

With simultaneous use with aminoglycosides, cephalosporins, vancomycin and rifampicin, synergism is developing.

The active ingredient increases influence indirect anticoagulantovAt the same time suppressing the intestinal microflora and reducing the synthesis of vitamin K.

Reducing concentration medicinal substance And the slowdown of absorption occurs against the background of the use of antacids, glucosamines, laxatives.

Manufacturer

The manufacturer is a pharmacological company from the Netherlands - ASTELLAS PHARMA EUROPE B.V.

Conditions of vacation from pharmacies

The pharmacies require a recipe from the doctor.

Price

The averaged price of tablets with a dosage of 500 mg ranges from 380-420 rubles.

Conditions and shelf life

The medicine is stored as room temperature away from sun rays. You should take care of children. Medication is 5 years.

Analogs

In the pharmacy, you can buy cheaper tools similar in composition:

1. Amoxicillin in capsules and suspension.
2. Amosin.
3. Gramoks-d.
4. Ospamex.
5. Ecobol.

Similar impact possess:

1. Ampicillin.
2. Standatskillin.
3. Augmentin.
4. Amoxiclav.

Preparation Fleaxin

Flexin with cystitis

This bactericidal remedy refers to semi-synthetic penicillins. Effective against all sorts of microorganisms, including gram-negative (capable of a long time resist the action of antibiotics). The active substance is the amoxicillin trihydrate, is 50% of the mass of the drug. In addition to him, the components are microcrystalline and dispersed cellulose, crosspovidon, magnesium stearate, as well as flavoring additives.

Form release

The manufacturer produces flossin in the form of white or light yellow tablets. Weighing 125, 250, 500 and 1000 mg, with engraving, respectively: 231, 232, 234, 236. The price in pharmacies depends on the size of the portions and ranges from 240 to 480 rubles. One package contains 20 tablets. The manufacturer is the Japanese company Atellas. Keep the medicine at a temperature of 15-25 ° C.

Pharmacological effect of the drug

Flexin does not give bacteria to create cell membranes due to blocking the main component of synthesis - peptidoglycan. This medication is quickly absorbed in gastrointestinal. The convenience of using it is associated with the possibility of free intake of food even simultaneously with the medicine, it will not affect the effect. Like any antibiotic, Flexing can only be used in accordance with the prescription prescribed.

The action of the medication begins shortly after use, and after an hour and a half reaches the maximum. Reception 1000 mg of Flexin brings concentration active substance in blood to 8 μg / l, in liquid gallbladder - 25 μg / l, in the octoplodic waters during pregnancy - 2.5 μg / l. These figures increase in proportion to the increase in dose.

Fifth part active component Enters into relationship with blood proteins. The accumulation of the drug occurs in the inner shells of hollow organs, bone tissue, eye chamber fluids, as well as in the mucous discharge from the respiratory tract and lungs. The remainder of the substance continues to operate in the body, creates additional protection against infection and speeds up recovery.

The healing compound does not pass through the BC (the barrier between the blood and central nervous system). But under meningitis, it falls in sufficient quantity into the cerebrospinal fluid.

The time of the preparation of the drug in adults from one to one and a half hours, in newborns and infants 3 times more. 90% of the substance comes out of the body for 8 hours, of which two thirds - with urine. Most of the products of amoxicilline metabolism are no effect on the body.

From what helps

Flexin is successfully struggling with various species Streptococci, tetanus and hemophilic stick, moraxella, sheets, chelicobacter pylori. It can be used against fecal enterococcus, protea Mirabilis, Salmonella (causing abdominal typhoid), Schigella zone, cholera vibrion. Does not affect microorganisms capable of synthesize beta lactamase. These include a blue rod, some proteins, enterobacteria.

List of readings:

• Bronchial, trachene and light diseases. For example, influenza, sinusitis, sinusitis.
• Inflammatory kidney pathologies (pyelonephritis), bladder (cystitis), leather (furuncoolosis, streptodermia, face), bone tissue (osteomyelitis), gastrointestinal tract.
• Some diseases of gynecology (adnexitis).
• Together with other medicines helps to cope with infectious mononucleosis, Blood infection, membranes.
• Used after surgical operations to prevent complications.

How to take adults

The individual dosage is influenced by such factors as the severity of the disease, susceptibility of this type of microorganisms to the drug, the age of the patient. During the day, an adult takes 1000-4000 milligrams of medicines for two servings.

Course of treatment with infections easy and middle severity lasts no more than a week. This period increases to 10 days when streptococcal infection. If the disease retreated, you can only stop the reception on the third day after the disappearance of the symptoms.

Method of application and dose, official instruction

How to take children

Calculation of children's dosage is carried out based on body weight. For each kilogram, about 40 mg of matter per day at the average severity of the disease and up to 180 are complications. A child over 10 years old needs to give two portions of 500 or 1000 milligrams. For younger age Doses of 250 mg are used, which are accepted 3 times during the day. Children 1-3 years old give 125 milligram three times per day.

Tablets are used both before meals and after it. The way they are in charge of the body can be like swallowing entirely, debris, drinking with glass of water and the preparation of a syrup or suspension. The soluble SOLUTAB shape is convenient for its pleasant taste (thanks to a lemon-tangerine filler) and rapidly absorption.

Angina reception scheme

This disease is caused by stafil and streptococci, very sustainable microorganisms. Only some antibiotics are able to effectively destroy them. Angina is accompanied by symptoms similar to cold: high temperature, sore throat, chills, weakness.

The study that detects the sensitivity of the pathogenic flora to medicines requires the cost of time that may not be in the case acute form Diseases. Flexin will be a good solution, because it acts quickly, universal and soft in terms of side Effects (Compared to other bactericidal means).

For a day, children over 10 years old and adults need to take about 1000-4000 milligram drugs for two servings. Better dissolve the remedy in water, the child willingly drink this suspension with pleasant odor. As an additional way to relieve inflammation will help inhalations.

The course of treatment with infections of easy and moderate severity lasts no more than a week. In cases where no improvements are observed within two days, the doctor must appoint another antibiotic. After recovery, it is recommended to pass therapy by probiotics to restore the natural balance of microorganisms in the intestine.

Scheme of reception at a hymorite

This disease is inflammation of air filled cavities connected with the nose. Symptoms: chills, temperature rise, mucus and purulent discharge, pressure of the nose, headache When tilting or compressing teeth. In the absence of treatment, this disease can go to chronic form and cause problems with vision, otitis, meningitis, periostites, systemic inflammation of the body (sepsis).

The disease can be caused by bacteria, viruses, fungi, allergic reactions. The presence of a pus with a high probability indicates a microbial source of infection. It is in the case bacterial infection The antibiotic is extremely effective. If the disease is caused by fungi, its use is contraindicated, and it does not work for viruses. Instructions for use advises to take 2000-3000 milligrams medicines for two servings. Allergic form Schimorite, like sometimes virus pass on their own.

Taking cystitis

A common disease of the bladder is also effectively treated with Flexin. In the first place, women and girls are in the first place of pathology, the second children are rarely infected with cystitis men. Since inflammation of the bladder walls is caused by bacteria, therapy with antibiotics becomes indispensable. During the day, it is recommended to take two tablets Flexin solutab 500 mg or 1000 mg.

Since insensitive bacteria can be attributed to the pathogens of cystitis, urine analysis should be made to identify the pathogen. In some cases, viruses act as sources of the disease, and therefore, Flexing will not help. During pregnancy, not only inflates bladder, but also the kidneys (pyelonephritis). In this case, there is a risk of miscarriage.

• Safety spasmolitis (but-shpa, drootaverin). They facilitate the tolerability of pain.
• Antipyretic (paracetamol). It is advisable to consist only at a temperature of more than 38 ° C.
• Medicines for comprehensive action, such as Uricesan and Kanefron. They remove inflammation, help against microbes and facilitate pain.

Useful also:

• Drink up to 3 liters of fluid during the day (pathogenic microbes come along with urine).
• Observe a diet. Salt and sharp spices cause irritation in mucous membranes.
• Applying a stomach book.

Flexing Salute and Alcohol

The use of drug with alcohol beverages is unacceptable because it weakens the protective systems of the body. Low immunity does not allow a person to resist the disease normally. As a result, the side effects specified in the annotations appear much more intensively. The digestive system is frustrated, the attacks of strong nausea and vomiting appear, sometimes disappears appetite. This adds destructive impact on the liver and kidney. Possible malignant tumors In the organs of the urogenital system.

Contraindications

• It is impossible to take people having sensitivity to polyicillin-based medicines and cephalosporin or to any of its components.
• It is not recommended to take during pregnancy and breastfeeding, with the exception of situations where other methods do not help.

Side effects

Unwanted treatment effects depend on the duration of reception of the means, the age of the patient and the individual characteristics of its body.

• More often responds to this drug digestive system. In such cases, there is an increase or decrease in appetite, diarrhea, nausea and vomiting. These symptoms may indicate an overdose of funds. Occasionally there is an acute diarrhea with blood, this is a sign of hemorrhagic colitis.
• If the patient is inclined to allergies, there is an edema and peeling on their arms and face, the rattling fever, a rash with itching.
• Less often arises tremor limbs, dizziness, fainting is possible.
• In rare cases, the cough is observed, the narrowing of the bronchi, the edema of Quint.
• If the patient is sick with mononucleosis or malignant lesion of lymphatic tissue, rash on the skin appears in most cases. This phenomenon occurs regardless of the sensitivity of the patient to Penicillin. With such a reaction, it is not necessary to stop receiving the means.
• There is also the likelihood of superinfection.
• Resisting the effects of penicillins, microorganisms produce cross-resistance to cephalosporins.
• In the treatment of cystitis, possible inflammatory processes In the kidneys of non-infectious nature.

Interaction with other substances

• Bactericidal medicines like rifampicin, reinforce the effect of the drug.
• Drugs Samplesid, phenylbutazone and xifenebutayon reduce the speed of half-life amoxicillin, respectively, its concentration in the blood increases.
• Flexin sometimes reduces efficiency contraceptive tablets With simultaneous use.
• If we use with it preparations, the overwhelming ability of bacteria to reproduction (tetracycline group, macrolides, chlorazphenicol), it can negatively affect its action.

Analogs

In addition to amoxyllicin, the active substance is clavulating acid, which allows the means to effectively cope with bacteria producing beta lactamase. This is due to the slowdown in the development of the protective enzyme by microorganisms. Produced in the form of tablets, syrup, injection powder, dry matter for the preparation of droplets and suspension.

Atelllas Pharma John B.V. Astellas Pharma Jourk B.V. / Ortat Za Yamanuchi Yourk B.V. / "Ortat"

Country of origin

Netherlands Netherlands / Russia Russia

Group of goods

Antibacterial drugs

Antibiotic group penicillins wide spectrum Penicillinase

Forms of release

• 5 - blisters (4) - Putures Cardboard 5 - blisters (4) - Cardboard packs. 5 - blisters (4) - Cardboard packs. 5 - blisters (4) - Cardboard packs.

Description of the dosage form

• Dispersible pills

pharmachologic effect

Bactericidic acid-resistant antibiotic of a wide range of action from a group of semi-synthetic penicillins. It is active against gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing beta-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori. Less active with respect to Enterococcus Faecalis, Escherichia Coli, Proteus Mirabilis, Salmonella Typhi, Shigella Sonnei, Vibrio Cholerae. Inactive with respect to microorganisms producing beta lactamases, Pseudomonas SPP., Proteus SPP. (Indol positive strains), Serratia SPP., Enterobacter SPP.

Pharmacokinetics

Suction after administration inside amoxicillin is absorbed quickly and almost completely (93%), acid resistant. Food reception practically does not affect the absorption of the drug. After the intake of 500 mg of amoxicillin Cmax of the active substance, a component of 5 μg / ml, is noted in the blood plasma after 2 hours. With an increase in or decrease in the dose of the drug 2 times the Cmax in the blood plasma is also changed by 2 times. The distribution of about 20% of amoxicillin binds to plasma proteins. Amoxicillin penetrates the mucous membranes, bone tissue, intraocular fluid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in the blood plasma is 2-4 times. In amniotic fluid and cord vessels, the amoxicillin concentration is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicilline penetrates poorly through the BGB; However, when inflammation brain shells Concentration B. spinal fluid It is about 20% of the blood plasma concentration. Amoxicillin metabolism is partially metabolized in the liver, most of its metabolites are not microbiologically active. The removal of amoxicillin is eliminated mainly by the kidneys, about 80% by canalish excretion, 20% - by glomerular filtration. In the absence of impaired kidney functions, the T1 / 2 amoxicillin is 1-1.5 hours. In premature, newborns and children under 6 months - 3-4 hours. Pharmacokinetics in special clinical cases T1 / 2 amoxicillin does not change when the liver function is disrupted. When the kidney function is violated (KK? 15 ml / min), the T1 / 2 amoxicillin increases and reaches 8.5 h under Anuria.

Special conditions

It should be prescribed a drug with infectious mononucleosis and lympholeciasis with caution, since the likelihood of non-allergic genesis is high. The presence of erythrodermia is in history is not a contraindication to assign Flexin Solyutab®. Possible cross-stability and cross-hypersensitivity with drugs penicillin row, cephalosporins. As with the use of other preparations of penicillin series, the development of superinfections is possible. The emergence of severe diarrhea characteristic of pseudomambranous colitis is an indication for cancellation of the drug.

Structure

• Amoxicillin (trihydrate) 125 mg Ancillary: cellulose dispersible, cellulose Microcrystalline, crosspovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. Amoxicillin (trihydrate) 125 mg Ancillary: cellulose dispersible, cellulose Microcrystalline, crosspovidone, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate. Amoxicillin (trihydrate) 1G excipients: cellulose dispersible, microcrystalline cellulose, crosspindon, vanillin, flavors (mandarine, lemon), saccharin, magnesium stearate. Amoxicillin (trihydrate) 1G excipients: cellulose dispersible, microcrystalline cellulose, crosspindon, vanillin, flavors (mandarine, lemon), saccharin, magnesium stearate. Amoxicillin (trihydrate) 250 mg Aids: cellulose dispersible, microcrystalline cellulose, crosspindon, vanillin, flavors (tangerine, lemon), sugar, magnesium stearate. Amoxicillin (trihydrate) 500 mg excipients: cellulose dispersible, microcrystalline cellulose, crosspindon, vanillin, flavors (tangerine, lemon), saccharin, magnesium stearate.

Flexin Soluteab reading to use

• Infectious-inflammatory diseases caused by microorganisms sensitive to the drug: - respiratory infections; - infections of the organs of the urogenital system; - infections of the gastrointestinal bodies; - skin infections and soft tissues.

Flexin Soluteab Contraindication

• - Increased sensitivity to the drug or other beta-lactam antibiotics. With caution, the drug should be used with polyvalent increased sensitivity to xenobiotics, infectious mononucleosis, lympholoicosis, history of the gastrointestinal tract (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and during lactation.

Flexin Solutab Dosage

• 1000 mg 125 mg 250 mg 500 mg

Flexin Soluteab Side effects

• From side digestive system: rarely - change in taste, nausea, vomiting, diarrhea; In some cases, a moderate increase in the activity of hepatic transaminases; Very rarely - pseudommbranous and hemorrhagic colitis. From the urinary system: very rarely - development interstitial nephritis. From the system of blood formation: very rare - agranulocytosis, neutropenia, thrombocytopenia, hemolytic anemia. Allergic reactions: skin reactions, mainly in the form of a specific maculo-papular rash; rarely - multiform exudative erythema (Stevens-Johnson syndrome); In some cases, anaphylactic shock, angioedema swelling. Side effects from the nervous system when the use of amoxicillin in dosage form Dispersed tablets are not registered.

Medicinal interaction

Slobalcid, phenylbutazone, oxyphenbutayone, to a lesser extent - acetylsalicylic acid and sulfinpyrazone suppress the tubular secretion of penicillin preparations, which leads to an increase in T1 / 2 and an increase in the concentration of amoxicillin in the blood plasma. Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin), while simultaneously taking synergism. An antagonism is possible when taking with some bacteriostatic preparations (for example, chloramphenicol, sulfonamides). The simultaneous reception of amoxicillin with estrogen-containing oral contraceptives can reduce the effectiveness of the latter and increase the risk of acyclic bleeding. The simultaneous use of amoxicillin with allopurinol does not increase the frequency of the skin reactions in contrast to the combination of allopurinol with ampicillin.

Overdose

Symptoms: disorders of the GTS - nausea function, vomiting, diarrhea; The consequence of vomiting and diarrhea may be a violation of the water and electrolyte balance. Treatment: Appointments of stomach, activated carbon, salt laxatives; Apply measures to maintain water and electrolyte balance.

Storage conditions

• dry
• bear from children
• storing

Information is provided by the state register of medicines.

Synonyms

• Amoxesar, Amoxicillin, Amosin, Ospamex, Ranoxyl, Hikcotil

Dispersible pills From white to light yellow, oval, with a company logo and a digital designation "231" on one side and risk separating the tablet in half, on the other side.

Excipients: Cellulose dispersible - 4.3 mg, microcrystalline cellulose - 6.3 mg, crosspindon - 6.3 mg, vanillin - 0.13 mg, mandarine flavor - 1.1 mg, aromatizer lemon - 1.4 mg, saccharin - 1.6 mg, magnesium stearate - 0.76 mg.

Dispersible pills From white to light yellow, oval, with a company logo and digital designation "232" on one side and risk separating the tablet in half, on the other side.

Excipients: Cellulose dispersible - 8.7 mg, microcrystalline cellulose - 12.6 mg, crosspose - 12.6 mg, vanillin - 0.26 mg, mandarine flavor - 2.3 mg, lemon flavor - 2.8 mg, saccharine - 3.3 mg, magnesium stearate - 1.5 mg.

5 pieces. - Blister (4) - Cardboard packs.

Dispersible pills From white to light yellow, oval, with a company logo and digital designation "234" on one side and risk separating the tablet in half, on the other side.

Excipients: Cellulose dispersible - 17.4 mg, microcrystalline cellulose - 25.2 mg, crosspindon - 25.2 mg, vanillin - 0.5 mg, mandarine flavor - 4.5 mg, lemon flavor - 5.6 mg, Sakharin - 6.6 mg, magnesium stearate - 3 mg.

5 pieces. - Blister (4) - Cardboard packs.

Dispersible pills From white to light yellow, oval, with a company logo and digital designation "236" on one side and risk separating the tablet in half, on the other side.

Excipients: Cellulose dispersible - 34.8 mg, microcrystalline cellulose - 50.5 mg, crosspindon - 50.4 mg, vanillin - 1 mg, flavoring mandarine - 9.1 mg, aromatizer lemon - 11.1 mg, saccharine - 13.1 mg, magnesium stearate - 6 mg.

5 pieces. - Blister (4) - Cardboard packs.

Clinical and Pharmacological Group

Antibiotic group of penicillins of a wide range of action that is destroyed by penicillinase

pharmachologic effect

Bactericidic acid-resistant antibiotic of a wide range of action from a group of semi-synthetic penicillins. The synthesis of peptidoglycan (supporting polymer of the cell wall) dislocation and growth, causes lysis bacteria.

Active in terms of gram-positive and gram-negative microorganisms:Streptococcus pyogenes, Streptococcus pneumoniae, Clostridium tetani, Clostridium welchii, Neisseria gonorrhoeae, Neisseria meningitidis, Staphylococcus aureus (not producing β-lactamase), Bacillus anthracis, Listeria monocytogenes, Helicobacter pylori.

Less active in relation Enterococcus Faecalis, Escherichia Coli, Proteus Mirabilis, Salmonella Typhi, Shigella Sonnei, Vibrio Cholerae.

Not active in relation tomicroorganisms producing β-lactamases, Pseudomonas SPP., Proteus SPP. (Indol positive strains), Serratia SPP., Enterobacter SPP.

Penicillinase strains, resistant to amoxicillin action.

Pharmacokinetics

Suction

After intake, amoxicillin is absorbed quickly and almost completely (93%), not destroyed in the acidic area of \u200b\u200bthe stomach. Food reception practically does not affect the absorption of the drug. After the intake of 500 mg of amoxicillin C MAX active substance, a component of 5 μg / ml, it is observed in the blood plasma after 2 hours. With an increase in or decrease in the dose of the drug 2 times C Max in the blood plasma is also changed by 2 times.

Distribution

Binding with plasma proteins is 17%. Amoxicillin penetrates into the mucous membranes, bone tissue, intraocular liquid and sputum in therapeutically effective concentrations. The concentration of amoxicillin in bile exceeds its concentration in the blood plasma is 2-4 times. In amniotic fluid and cord vessels, the amoxicillin concentration is 25-30% of its level in the blood plasma of a pregnant woman. Amoxicilline penetrates poorly through the BGB; However, with inflammation of the brain shells, the concentration in the spinal fluid is about 20% of the blood plasma concentration.

In small quantities stand out with breast milk.

Metabolism

Amoxicillin is partially metabolized in the liver, most of its metabolites are not microbiologically active.

Election

Amoxicillin is excreted by 50-70% by the kidneys unchanged (by canalis excretion - 80% and glomerular filtration - 20%), liver - 10-20%.

In the absence of violation of kidney functions T 1/2 Amoxicillin is 1-1.5 hours. In premature, newborns and children under 6 months - 3-4 hours.

Pharmacokinetics in special clinical cases

T 1/2 Amoxicillin does not change when the liver function is broken.

If the kidney function is violated (KK ≤ 15 ml / min) T 1/2 amoxicillin increases and reaches 8.5 h at anouria.

Amoxicillin is removed from the organism during hemodialysis.

Indications for the use of the drug

Infectious-inflammatory diseases caused by microorganisms sensitive to the drug:

- infections of respiratory organs;

- infections of the organs of the urogenital system;

- infections of the gastrointestinal bodies;

- skin infections and soft tissues.

Dosing mode

The drug is taken inward. The drug is prescribed before, during or after meals. The tablet can be swallowed entirely, divided into parts or dear, picking a glass of water, and can also be dissolved in water to form a syrup (in 20 ml) or suspension (in 100 ml) with a pleasant fruit taste.

The dosing mode is established individually, taking into account the severity of the course of the disease, the sensitivity of the pathogen to the drug, the age of the patient.

When infectious inflammatory diseases of light and moderate It is recommended to use the drug according to the following scheme: adults and Children over 10 years prescribe at 500-750 mg 2 times / day or 375-500 mg 3 times / day; children aged 3 to 10 years prescribed 375 mg 2 times / day or 250 mg 3 times / day; children aged 1 to 3 years Assign 250 mg 2 times / day or 125 mg 3 times / day.

Daily dose of the drug for children ( including children up to 1 year) It is 30-60 mg / kg / day, divided by 2-3 receptions.

For treatment of severe infections as well as difficult foci infection (for example, acute Middle Otitis) is recommended three-time reception.

For chronic diseases, recurrent infections, severe infections adults prescribe at 0.75-1 g 3 times / day; children - 60 mg / kg / day, divided into 3 receptions.

For acute uncompressed gonor. Press 3 g of preparation in 1 reception in combination with 1 g of probe.

with CK≤10 ml / min

When infections of light and medium severity The drug is accepted within 5-7 days. However, with infections caused by Streptococcus Pyogenes, the duration of treatment should be at least 10 days.

Reception of the drug must be continued within 48 hours after the disappearance of the symptoms of the disease.

Side effect

From the digestive system: rarely - change in taste, nausea, vomiting, diarrhea, dysbacteriosis, stomatitis, glossitis; In some cases, a moderate increase in the activity of hepatic transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolithic hepatitis, pseudommbranous and hemorrhagic colitis.

From the urinary system: Development of interstitial jade, crystalluria.

From the hematopopitation system: leukopenia, neutropenia, thrombocytopenic purpura, eosinophilia, thrombocytopenia, agranulocytosis, hemolytic anemia.

From the nervous system: Excitation, anxiety, insomnia, ataxia, confusion of consciousness, change behavior, depression, peripheral neuropathy, headache, dizziness, epileptic cramps.

Allergic reactions: Skin reactions, mainly, in the form of a specific maculo-papular bulkey, urticaria, hyperemia, erythematous rash, rhinitis, conjunctivitis, multiform exudative erythema (Stevens-Johnson syndrome), fever, arthralgia, eosinophilia, exfoliative dermatitis, reactions similar to serum disease, toxic epidermal necroliz, allergic vasculitis, acute generalized examatosis of Pustulatis; In some cases, anaphylactic shock, angioedema swelling.

Others:difficult breathing, candidomicosis of the vagina, superinfection (especially in patients with chronic diseases or reduced organism resistance).

Contraindications for the use of the drug

- increased sensitivity to the components of the drug;

- Increased sensitivity to other beta-lactam antibiotics, incl. To other penicillins, cephalosporins, carbapenes.

FROM caution The drug should be used with polyvalent heightened sensitivity to xenobiotics, infectious mononucleosis, lympholoicosis, diseases of the gastrointestinal tract (especially with colitis associated with the use of antibiotics), renal failure, during pregnancy and during lactation, allergic reactions (including a history).

Application of the drug during breastfeeding and breastfeeding

The use of the drug Flexin Soluteab ® during pregnancy and during lactation is possible if the expected benefit of therapy for the mother exceeds the risk of developing side effects from the fetus and an infant.

In small quantities, amoxicillin is distinguished with breast milk, which can lead to the development of sensitization phenomena in an infant.

Application with violations of the kidney function

Patients with impaired kidney function for Kk≤10 ml / min Dose of the drug is reduced by 15-50%.

special instructions

It should be prescribed a drug with infectious mononucleosis and lympholeciasis with caution, since the likelihood of non-allergic genesis is high.

The presence of erythrodermia in history is not a contraindication for the preparation of the drug Flexin Soluteab ®.

Cross-resistance with penicillin row and cephalosporins are possible.

The emergence of severe diarrhea characteristic of pseudomambranous colitis is an indication for cancellation of the drug.

During course treatment, it is necessary to control the condition of the function of the blood formation, liver and kidney organs.

It is possible to develop superinfection due to the growth of microflora insensitive to the drug, which requires an appropriate change in antibacterial therapy.

For treatment easy diarrhea against the backdrop of course treatment should be avoided by antidiaric drugs that reduce intestinal peristalsis; You can use kaolin- or attapulgite-containing anti-divine medicinal products. Treatment necessarily lasts 48-72 hours after disappearance clinical symptoms Diseases.

With the simultaneous use of estrogen-containing oral contraceptives and amoxicillin, if possible, use other or additional methods of contraception.

Impact on the ability to driving vehicles and control mechanisms

Not reported on the adverse effects of the drug on the ability to manage vehicles Or working with mechanisms.

Overdose

Symptoms: disorders of the function of the tract - nausea, vomiting, diarrhea; The consequence of vomiting and diarrhea may be a violation of the water and electrolyte balance.

Treatment: Press the stomach, activated carbon, salt laxatives; Apply measures to maintain water-electrolyte balance, hemodialysis.

Medicinal interaction

Samplesidacid, phenylbutazone, oxyphenbutaone, diuretics, allopurinol, NSAIDs, to a lesser extent - acetylsalicylic acid and sulfinpyrazon are suppressed by the tubular secretion of penicillins, which leads to an increase in T 1/2 and an increase in the concentration of amoxicillin in the blood plasma.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, vancomycin, rifampicin), while simultaneously taking synergism.

An antagonism is possible when taking with some bacteriostatic preparations (for example, chloramphenicol, sulfonamides).

The simultaneous reception of amoxicillin with estrogen-containing oral contraceptives can reduce the effectiveness of the latter and increase the risk of acyclic bleeding.

Antacids, glucosamine, laxatives, aminoglycosides, food reduce absorption. Ascorbic acid increases absorption.

Increases the efficiency of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and the prothrombin index); Enhances the absorption of digoxin.

The simultaneous use of amoxicillin with allopurinol increases the risk of skin rash.

Conditions of vacation from pharmacies

The drug is released by the prescription.

Terms and Storage Terms

The drug should be stored in an inaccessible place at temperatures not higher than 25 ° C. Shelf life - 5 years.

Flexin is a generic of one of the most popular antibiotics in the world. The original preparation was developed by British pharmacists in the 60s of the last century. At the pharmaceutical market, Amoxicillin appeared in the early 70s.

Amoxicillin, no doubt, is among the most secure antibacterial preparations of a wide range. According to some data, this penicillin antibiotic Is almost the most dischargeable medicine in pediatrics. Almost every solid pharmaceutical company He considers his duty to release his "amoxicillin." The Japanese Astllas Pharma Corporation also succeeded in this case by developing Flexin.

Flexin SOLUTAB is allocated on a monotonous background of amoxicillins due to its form of release. After all, the drug is produced in the form of dispersible pills, which have a lot of advantages compared to our usual pills.

In this article, we will try to understand how Flexin is different from analogs, and also clarify the positive aspects of the drug. And we will not bypass the negative qualities that, of course, are also present.

ASTELLAS PHARMA: Antibiotics - new life

ASTELLAS PHARMA is the largest Japanese pharmaceutical concern. It appeared in 2005 thanks to the merger of two famous Japanese companies: Fujisawa Pharmaceutical Co and Yamanouchi Pharmaceutical Co.

Today, Astellas Pharma works in different directions of medicine, creating both original drugs and analogues of famous brands. The company also produces several antibiotics that have gained wide fame due to the dispersible form of release.

Each of these drugs has an additional word in the title indicating a special form, Soluteab. The dispersible preparations include:

• cephalosporin antibiotic Ceforal Solutab;
• Unidox Solutab, well-known in Russia;
• Vilprafen Soluteab;
• Flexin Solyutab and Flemoclav Soluteab are two related drugs containing amoxicillin as an active substance.

I would like to note that Flexin Soluteab is registered only Germany, Iceland, Portugal and CIS countries.

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Flexin Solutab: composition of the drug

Flexin includes how you have already understood, the only active component is amoxicillin - in the form of a stable connection (trihydrate).