Imprine for narrowing pupils and improving outflow of intraocular fluid. Izdigin (Eye Drops): price, reviews, analogues, instructions for use of therapeutic drops Icifilla for children

06.08.2020 Products

Eye drops of ICFRIN in ophthalmology are used locally for the narrowing of vessels, expanding the pupil or reducing intraocular pressure.

Such an effect is achieved thanks to the main active agent substance - phenylephrine.

The medicine is enough wide spectrum Applications, because the expansion of the pupil and the decline intraocular pressure Important for the treatment and diagnosis of many eye diseases.

Instructions for use

Beneficial features

Basic active substance The drug is phenylephrine, relating to sympathomimetics and having alpha adrenergic activity, which under local use causes the expansion of the pupil.

It is also observed an improvement in the outflow of intraocular liquid and a moderate narrowing of the blood vessels. In the fabric of the eye, phenylephrine penetrates enough and quickly, the expansion of the pupil is observed for 10-60 minutes after the instillation.

Release form and composition

Dosage form IRFRINIRINA - drops. They are a transparent solution of colorless or yellowish shade. Available in special 5 ml plastic bottles with a dispenser, which, in turn, packed in cardboard boxes.

Drops are different percentage ratios 2.5% and 10%. Active acting component - phenylephrine hydrochloride.

In 1 ml of 2.5% of the solution, 25 mg of the active component is included, and in 1 ml of a 10% solution of 100 mg.

Additional components in the composition of the drug: Benzalkonium chloride, Dinatarium, hypimon, sodium metabisulphite, citric acid, sodium citrate dihydrate, distilled water.

Indications for use

The drug is prescribed in the following cases:

before ophthalmic operations (including laser), which require the state of mydriasis;
in hyperemia conjunctiva, in order to determine the type of injection;
if necessary, expand the pupil to diagnose the eye;
with iridocyclite (inflammatory disease of the ciliary body and iris, the eye).

Interaction with other medicines

Simultaneous use with atropine leads to increased action of both means. As a result, the risk of developing tachycardia appears.

Sharing with beta blockers provokes risk of raising arterial pressure.

When using Inefircin at the same time or for 21 days after the receipt of the Mao inhibitors is completed, there is a risk of an uncontrolled pressure lift.

With simultaneous use with propranolol, methyldop, reserpine, tricyclic antidepressants, M-cholinoblockers and guanethidine, the vasopressor effect of adrenomimetic agents may be potential.

The use of a 10% solution of iRifirodium simultaneously with the system use of beta-adrenoblockers can provoke the appearance of acute arterial hypertension.

With inhaled anesthesia, the medicine is able to potentiate an inhibitory effect on the cardiovascular system. Sharing and sympathy with sympathomimetics can enhance the cardiovascular effect of phenylephrine.

How to use the drug?

The use and dosage of the drug in relation to each disease is different.

Ophthalmoscopy.. With ophthalmoscopy use 2.5% solution once. In order to achieve the expansion of the pupil, or the mydriasis is introduced 1 drop. The maximum expansion of the pupil is achieved after 15 - 30 minutes and the state is stored for 1 to 3 hours. If there is a need to maintain medria for a longer time, it is possible to repeated drops of drops after 60 minutes.

Drops of 10% of the composition can be used with insufficient medria in children over 12 years old and adults, in patients with a rigid iris.

Accommodation spasm, or false myopia. 2.5% of drops of children over 6 years old and adults are used to remove the spasm. I bury 1 drop in every conjunctival bag for the night every day. Application course - 28 days, or 4 weeks.

With a resistant spasm for children over 12 years old and adults allowed to use 10% solution. Drip 1 drop in every eye for the night every day. The course of treatment is twice as smaller - 14 days, or 2 weeks.

Iridocyclty. With this kind of inflammation, 2.5% eye fluid or 10% is used. ICFRIN prevents the development and gap of the existing rear synechs and reduces the release of fluid into the front chamber of the eye. In each eye, you dig 1 drop of about 2 to 3 times a day.

Glaugeomocyclic crisis, or Posner Schlossman Syndrome. ICRIPRIN due to the active component in the composition reduces intraocular pressure, especially pronounced action have drops having 10% composition. Apply 2 - 3 times a day.

Preparation for surgical interventions. 10% drops are used for half an hour or an hour before the operation in order for the expansion of the pupil. Mart once. After opening the shell eyeball Installing the means is no longer permissible. Also, data drops are not used for irrigation, wetting tampons during operations and subconjunctive administration.

Diagnostics.Drops are used to diagnose various diseases Single in the form of a 2.5% solution. Used for:

1. Provocative test In patients having a narrow angle profile of the anterior caper, as well as suspected of a closedian glaucoma. The difference between the value of intraocular pressure before I was commissioned by ICF and after expanding the pupil should be from 3 to 5 mm Hg. With such indicators, the test is considered positive.

2. Differential diagnosis of the type of injection of the eyeball.If after the instillation in five minutes there was a narrowing of the vascular of the eyeball, then the injection is defined as superficial. If redness has been preserved, it is important to examine the patient for the presence of such a disease as iridocyclite or scarce, as redness may indicate the expansion of deeper vessels.

Contraindications

hemoglobin metabolism;
clotted and narrowed glaucoma;
serious cardiovascular diseases;
hyperthyroidism;
increased sensitivity to the components of the means.

In addition, these drops should not use older patients with organic changes in the work of the brain and heart vessels. 10% solution of the drug should not be used by children aged less than 12 years and children with insufficient body weight.

Considering the fact that the action of Irifirin on the body during pregnancy and breastfeeding It is not well studied, the use of funds in these cases is possible only when the expected benefit from its application is exceeding possible risk For the fetus or child.

Side effects

The drug I and Idifirin has a number of side effects that develop very rarely, but they should be known about.

When using data eye drops Such reactions such as local irritation, itching, tearing, deterioration of visual acuity, burning in the eyes can appear.

Due to the use of droplets, elderly patients, in a day, they can observe a reflex narrowing of pupils.

In some cases, the drug can provoke aggravation of heart disease and vessels, violation heart Rhythm, Enhance arterial pressure.

In rare cases, the use of IRFINIRINA leads to serious violations from the cardiovascular system, such as a vascular collapse, myocardial infarction and intracranial hemorrhage.

Overdose

Upon local use and compliance with the rules indicated in the instructions, the drug is not observed.

special instructions

It is necessary to avoid contact of the eye drops of ICF with contact lenses - before instilling the eye, it is necessary to remove lenses from them. You can wear them at least after half an hour after instillation of the drug.

ICFRINI must be applied with particular care to patients with diabetes mellitus, since there is a risk of increase in pressure caused by a violation of vegetative regulation.

Also, with caution, the drug must be appointed by older patients due to the increase in the risk of reactive mine.

In case of exceeding the recommended dose using a 2.5% solution of ICRIFIN Patients with diseases or injuries of the eye or its appendages, with reduced tear-product or in postoperative period It is possible to increase the absorption of phenylephrine, which can cause the development of system side effects.

Terms and Storage Terms

The shelf life of drops of 24 months. After opening the bottle can only be used for 1 month. Store away from the sunlight at a temperature that does not exceed 25 ° C. Drops can not be frozen. Keep away from children. Released only on the recipe.

IZRIFRIN: instructions for use and reviews

ICFRINIRIN - a drug with an alpha adrenomimetic action used in ophthalmology.

Release form and composition

Iciforine is produced in the form of drops of an eye 2.5% and 10%: a transparent solution from light yellow to colorless (5 ml in dark glass vials complete with dropper or plastic flocks-droppers, 1 bottular dropper or a bottle in cardboard pack).

The composition of 1 ml drops includes:

Active substance: phenylephrine - 25 or 100 mg (in the form of hydrochloride);
Auxiliary components: Benzalconium chloride, Dinatarium Edetat, sodium hydroxide, sodium metabisulphite, citric acid, sodium citrate dihydrate, water for injection; Additionally for 10% drops: sodium hydrophosphate dihydrate, anhydrous sodium dihydrophosphate.

Pharmacological properties

The alpha-adrenomimetic effect of the drug is a narrowing of vessels and strengthening the reduction in smooth muscles.

Pharmacodynamics

Phenylephrine - sympathomimetic with distinct alpha adrenergic activity. When receiving in therapeutic doses, this substance is not characterized by a significant stimulating effect on the CNS.

For local application in ophthalmological practice Phenylephrine determines the narrowing of the conjunctival vessels, improving the outflow of intraocular fluid and the expansion of the pupil. Active Component Iriforina has a pronounced stimulating effect on postsynaptic alpha-adrenoreceptors, slightly affecting the functioning of the beta-adrenoreceptors of the heart.

When prescribing the drug, its vasoconstrictor action is noted, similar to the action of norepinephrine (norepinenaline). The influence on the heart of an inotropic and chronotropic nature is practically absent. The vasopressor effect of phenylefrin is weaker than that of norepinephrine, but is more prolonged. Vasoconstriction is observed after 30-90 seconds after instillation, the action of IRFINIZIN lasts 2-6 hours.

Instillation of phenylephrine leads to a reduction in the pile of pupil and smooth muscle arteriole conjunctiva, causing the expansion of the pupil. Midships are registered for 10-60 minutes after one-time instillation. After administration of 2.5% of the solution, the effect is maintained for 2 hours, a 10% solution of IRFIRINA - for 3-7 hours. Midship, the cause of which is phenylephrine, does not accompany the cycloplegia.

Pharmacokinetics

Phenylephrine easily penetrates the eye fabric, and its maximum blood plasma concentration is detected 10-20 minutes after local application. The preliminary introduction of local anesthetics can extend the state of the mydriasis and increase systemic absorption. Phenylephrine is excreted through the kidneys unchanged (less than 20%) or in the form of metabolites that do not have pharmacological activity.

Indications for use

Glaucomo-cyclitic crises (treatment);
Iridocyclite (prevention of the occurrence of the rear synechs (scapups) and to reduce the exudation from the iris);
"Red Eye" syndrome (treatment with the aim of reducing irritation and hyperemia of the shells of the eye, 2.5% of ICF) applies);
Accommodation spasm;
Diagnostic expansion of the pupil when examining the eye bottom (ophthalmoscopy) and conducting other diagnostic procedures for monitoring the state of the rear segment of the eye;
Differential diagnosis of injection (deep and surface) eyeball;
Provocative test in patients with a narrow angle of the anterior chamber of the eye and when suspected a closotagonal glaucoma;
Laser interventions on the eye days, vitreoretinal surgery (for the expansion of the pupil);
Preoperative preparation for the expansion of the pupil in ophthalmosurgery (10% of ICF) is used).

Contraindications

Glaucoma (narrowgonal or indoor);
Aneurysm arteries (for 10% of eye drops);
Hepatic porphyria;
Hyperthyroidism;
Congenital deficiency of glucose-6-phosphate dehydrogenase;
Age up to 12 years (for 10% of eye drops);
Hypersensitivity to the components of the drug.

Also eye drops Izifirin is contraindicated to apply elderly patients who have serious violations of the cerebral circulation and cardiovascular system, premature children (for 2.5% of eye drops) and as a means for additional expansion of the pupil during surgical operations in disruption of tear-products, as well as in patients with integrity impairment Eye apple.

The use of IRFINIRINA with nursing and pregnant women is possible only in cases where the expected benefit to the health of the mother is higher than the existing risk for the child or the fetus (due to the insufficiency of clinical data on the safety and effectiveness of therapy in this category of patients).

Instructions for use Inesifirina: Method and dosage

When conducting ophthalmoscopy in the form of instillations, 2.5% of the eye drops are applied once. Usually, it is enough to create a mydriasis of 1 drops into a conjunctival bag. The maximum expansion of the pupil is achieved after 15-30 minutes, for 1-3 hours, mydriasis is saved on sufficient level. If it is necessary to maintain the expansion of the pupil for a long time, after 1 hour, it is possible to re-instillation of ICRIFIRINA.

In case of insufficient expansion of the pupil in adults and children from 12 years, as well as in patients with rigid iris (pronounced pigmentation), 10% of the eye drops can be used for diagnostic expansion of the pupil in the same dose.

To remove the accumulation of accommodation to adults and children from 6 years old are prescribed 2.5% eye drops - daily 1 drop in each eye for the night for 4 weeks.

With an accommodation resistant accommodation in adults and children from 12 years old, it is possible to use 10% of the eye drops - daily 1 drop in each eye for the night for 2 weeks.

When conducting diagnostic procedures, one-time instillation of 2.5% of the eye drops are used in the following cases:

Provocative test in patients with a narrow profile of an angle of the anterior chamber and when suspected a closedian glaucoma. The test results are considered positive in cases where the difference between the values \u200b\u200bof intraocular pressure before the use of IPness and after the expansion of the pupil fluctuates in the range of 3-5 mm Hg;
Differential diagnosis of the type of eye supplement injection. When the vessels of the eyeball of the eyeball is 5 minutes after the injection, the injection is classified as superficial, when preserving eye redness, it is necessary to carefully examine the patient for the presence of a curler or iridocyclitis, since this indicates the expansion of the lying deeper vessels.

In case of iridocyclitis to reduce exudation (liquid release from small blood vessels during inflammation) into the front chamber of the eye and to prevent the formation and rupture of the already existing rear synechs, 2.5% or 10% of I and 10% are used - 1 drop in the conjunctival bag of the patient's eye (eye) 2-3 times a day.

Due to the vasoconstrictor action of phenylephrine in glauer-cyclic crises there is a decrease in intraocular pressure. This action is more pronounced when applying 10% of IPness. To relieve glaucoma-cyclic crises, the drug should be bought 2-3 times a day.

When preparing for surgery 30-60 minutes before it is to expand the pupil, a single instillation of 10% of the eye drops of IP is produced. After the eye apple shell opens, repeated application The drug is not allowed.

10% of drops are not used for irrigation, subconjunctive administration and impregnation of tampons during operational interventions.

Side effects

When using IRFIRINA, the development of violations by some organism systems is possible:

Cardiovascular system: Tachycardia, heartbeat feel, arrhythmia (including ventricular), reflex bradycardia, arterial hypertension, embolism pulmonary artery and occlusion coronary arteries; rarely (with the use of 10% drops) there are serious disorders, including myocardial infarction, intracranial hemorrhage and vascular collapse;
The organ of view: periorbital edema, conjunctivitis; At the beginning of use, it is possible to tear, a feeling of burning, an increase in intraocular pressure, irritation, irritation, a sense of discomfort. The next day, after applying, Incenter can develop jet MIOs. Midships during repeated instillations of the drug during this period may be somewhat less pronounced than the day before (more often in senior patients). 30-45 minutes after instillation due to a significant reduction in the pupil dilator under the influence of the active substance (phenylephrine) in the wicking of the front chamber of the eye, the pigment particles from a pigment leaf of the iris can be detected. Silence in chamber moisture should be differentiated with the ingress of blood shaped blood elements in the moisture of the anterior chamber or with the development of anterior uveit;
Dermatological reactions: contact dermatitis.

Overdose

The symptoms of overdose are the manifestations of the system action of phenylephrine. In this case, alpha-adrenoblays are often introduced (for example, 5-10 mg of fantolamine intravenously). If necessary, the procedure is repeated.

special instructions

According to the instructions, ICFRINI should be used with caution in elderly patients (due to an increase in the risk of reactive mine) and in patients with diabetes mellitus (due to the risk of improving blood pressure associated with impaired regulation).

Also, the drug is prescribed with caution simultaneously with monoaminoxidase inhibitors and for 21 days after the termination of their use.

Excess recommended doses when using 2.5% drops in patients with injuries, eye diseases, or their appendages, in the postoperative period or with reduced tear products (due to anesthesia) can lead to an increase in phenylephrine absorption and, consequently, to the development of systemic side effects.

Due to the fact that Intrinine causes hypoxia conjunctiva, it must be used with caution when wearing contact lenses, in patients with sickle-shaped anemia, as well as after surgery (due to reduced healing).

Childcare

Intrinine used B. pediatric practice: 2.5% solution - in children from 6 years, 10% solution - in children from 12 years.

Medicinal interaction

With simultaneous use of ICRIRININ with some drugs Unwanted effects may occur:

Atropine: strengthening the Midritic effect of phenylephrine; Tachycardia is also possible due to increased vasopressor;
Monoaminoxidase inhibitors (at the same time for 3 weeks after the end of their use): the risk of developing an uncontrollable lifting of blood pressure;
Tricyclic antidepressants, propranolol, reserpine, guananetidine, methyldop and m-cholinoblocators: vasopressor potentiation;
Beta-adrenoblays (systemic use): the development of acute arterial hypertension (with the use of 10% drops);
Inhalation anesthesia: the potentation of the oppressive effect on the cardiovascular system;
Sympathomimetics: Strengthening the cardiovascular effects of phenylephrine.

Analogs

Analogues of Inesifirin are: Visoofrin, Izdarin BC, Mesothton, Nazol Baby, Nazol Kids, Neosinephrin-pos, FENEFRIN 10%.

Terms and conditions of storage

Store in the place protected from light, inaccessible for children at temperatures up to 25 ° C, do not freeze.

Shelf life - 2 years.

After opening the bottle, the drop can be used within 1 month.

Thank you

The site provides reference information solely to familiarize yourself. Diagnosis and treatment of diseases must be under the supervision of a specialist. All drugs have contraindications. Consultation of a specialist is obligatory!

Icifrin It is an ophthalmological drug used locally ( drops in the eyes) and the following effects: the expansion of the pupil, the improvement of the outflow of intraocular fluid and the suspension of the vessels of the conjunctival shell. Eye drops Iciforin are used for iridocyclite to reduce the amount of separated iris, with glaucomo-cyclic crises, with red-eye syndrome, accommodation spa, as well as to expand the pupil during operations and preoperative preparation.

Varieties, titles, form of release and composition

Currently, on the pharmaceutical market there are two of the following varieties of the drug - this is I and I and I and Intrinine BC. These varieties of the same drug are distinguished by the fact that in the eye drops of IRFRINIR there is a preservative, and there is no such an ICRIRIN in the BC. This means that ordinary drops of ICFRIN may become more likely to cause eye irritation, but it is longer stored after opening the bottle. A drops of ICFRINIR BC, not containing preservative, are not stored after opening the bottle and have a practically zero risk of irritation.

In addition, drops of ICFRIN with a preservative are produced in a volume of 5 ml, they can be used multiple times for one month, since it is precisely for 30 days to store and use a revealed tube with a solution. That is, after the discovery of the vial during the month, it is possible to gain a solution with a pure pipette unlimited number.

Drops ICFRINI BC, not containing preservative, are produced in small 0.4 ml dropper bottles, which are designed specifically for one-time application. Such a bottle must be used completely immediately after opening, and only once. That is, the small bottle of IRFINIRINA BC is opened immediately before use and immediately bury the solution into the eye. If some solution remains in the vial, it is not subject to storage, and therefore it is thrown out. For each next use, the new bottle of ICRIRINITRINIA BC is revealed.

Otherwise any difference in the composition or therapeutic effect There is no BC between Irifirin or Izifirino. In use, both varieties of the drug are usually united under one common name "Imprin", only if necessary, it is detailed and indicating what kind of drug version are we talking about. In the future text of the article, we will also be both varieties of the drug called Irifirine, indicating the exact name only if necessary, emphasize attention on any specific properties inherent in one or another kind of medication.

ICRIRINA and ICFRINIR BC are available in the only dosage form - These are drops for the eyes. As an active substance drops contain phenylephrin In various dosages. Thus, the ICFRIN drops are produced in two dosages - in the form of 2.5% and 10% solution. And the IRFRINIRI of the BC is available only in the form of a 2.5% solution. Intrinine 2.5% and IRFRINIR BK contain 25 mg of phenylephrine in 1 ml of solution. Accordingly, I and Finigine 10% contains 100 mg of phenylephrine in 1 ml of solution.

Excipients Both varieties of ICRIFIRINA are reflected in the table.

*Incentive Izifirin 2.5%*	*Incentive Incentive Incenter 10%*	*Auxiliary substances Incenter BC*
Water for injections
Sodium citrate dihydrate
Lemon acid
Sodium metabisulfit
Sodium hydroxide
Dinatari Edestat
Benzalconium chloride (preservative)		Hypromellos
	Sodium dihydrophosphate anhydrous
	Sodium hydrophosphate dihydrate

All solutions are iriforid transparent, colorless or light yellow. Intrinine 2.5% and 10% are produced in 5 ml vials, and the ICF is 0.4 ml in bottles-dropper bottles. Each package contains 15 bottles of IRFINIZINA BC, or 1 vial of Inefyrin 2.5% or 10%.

Therapeutic action

The active substance of Irifirod Phenylephrine is an alpha adrenomimetic, respectively, has an impact on the smooth muscles of blood vessels. When using phenylephrine in the form of eye drops, the drug affects only the vessels of this organ. If phenylephrine is administered intravenously or subcutaneously, it has an impact on all vessels in the human body, as well as on the heart.

Application of droplets Irifirin on the mucous membrane of the eye causes the expansion of the pupil, enhances the outflow of intraocular fluid, and also narrows blood vessels conjunctiva. The narrowing of the vessels of the conjunctiva ensures the disappearance of the redness of the eye, as a result of which the drug is used in the therapy of the "red eyes" syndrome. Strengthening outflow of intraocular fluid provides an improvement in the condition of the eye when glauer. And the expansion of the pupil caused by the IP drops is used to preoperative preparation or in the process of conducting surgical intervention in the eyes.

The narrowing of the eye vessels occurs after 30 - 90 seconds after making the droplets on the conjunctival. The expansion of the pupil occurs after 10 - 60 minutes after a single injection of the solution, and is preserved for 2 hours when using 2.5% I and 3-6 hours when using 10% drops.

Indications for use

Roplets of ICFRIN and ICFRINIR BC of various concentrations are shown to use in the same following cases:

Reducing the number of inflammatory separated iris shell and preventing the formation of synechs (battles) with iridocyclite (inflammation of the iris or ciliary body of the eye);
To distinguish the surface and deep injection of the eyeball;
To carry out a provocative test, which allows you to confirm or, on the contrary, reject suspicion of the closed gloom in people with a narrow angle of the front chamber of the eye;
Expansion of the pupil when conducting diagnostic procedures, such as ophthalmoscopy, monitoring the state of the rear segment of the eye, etc.;
As a means for preoperative preparation for the expansion of the pupil (only for 10% drops);
To expand the pupil in the production of laser surgical operations on the fundus (for example, laser vision correction, etc.) - optimal 10% drops;
To expand the pupil in the production of manipulations of vitreoretinal surgery (optimal 10% drops);
Treatment of glaucomous-cyclitic crises (optimal 10%);
Treatment of red-eye syndrome (only 2.5% drops of I and I and I and I and BC);
The elimination and treatment of spasmodation spasm, which is also called false myopia (spasm of the ciliary muscle of the eye, which occurs during a long focusing and holding a look at any or closely located subjects, as a result of which the body is overwhelmed, and a person loses normal visual sharpness for it near or in the distance).

If in brackets next to the indication it is indicated that it is only for droplets of one or another concentration, then it should be used in the presence of this state or illness of an exclusively meaning an iphirin version. If the "optimal" drops of any concentration are indicated in brackets next to the indication, then this means that the specifies are suitable for this state, but others can also be used.

IZRIFRIN - instructions for use

General provisions

I am 2.5% IC drops and 10%, as well as IRFRINRINIR BK applied according to the same rules. Choosing a variety of drops (IRFRINIR or ICF) depends mainly, from a preservative man tolerability - benzalconium chloride . This means that if a person normally transfers this preservative (for example, in the past, droplets containing the same preservative), it can choose any type of drug, proceeding exclusively from personal, subjective preferences (for example, packaging any species like more and etc.) If a person does not tolerate a preservative, then he needs to use drops ICFRI BK.

As for the choice of dosage, the doctors recommend for independent use to always start using 2.5% IRFINIRINA or ICRIPITRINES BC. If the solution of this concentration is not effective in this particular case, it can be replaced with 10% by IZMIRIN. Immediately use 10% of ICF only for preoperative preparation in the hospital. In the elderly people (over 65 years old) and babies should avoid the use of 10% of IRFINIRINA, since they have a very high risk of phenylephrine absorption in the bloodstream and system development. In patients with data of age groups, it is better to use 2.5% I am I and I and I and BC.

The IP solution of 10% can be used in various ways, such as hardening in the eyes, impregnation of tampons and impose them to the surface of the conjunctiva, as well as the introduction of injection into tissue. Incemic solutions 2.5% and IRFRINRI BC are used only in the form of droplets in the eye.

Injecting Introduction Irifirod 10% is only a doctor. And to bury the solution into the eyes or apply it in the form of applications (put the tampons impregnated with the drug) can be independently. When using a solution for diagnostic and preparatory manipulations (for example, ophthalmoscopy, before operations, etc.) it should only be bought. If the solution is used for iridocyclite, glaucoma-cyclic crises or accommodation spasm, it can be bought or applied in the form of applications. The choice of a method of application is carried out on the basis of personal preferences and considerations of convenience, as well as the recommendations of the doctor.

The vials of 2.5% and 10% of IRFIRINA can be stored within a month after opening and, accordingly, to use a solution for 30 days. BC IRFINIZINA BC is opened immediately before using the drug and are not stored in principle. If, after instillation of the solution, the ICF in the vial remains any amount of the drug, it should be thrown out, since it is not subject to storage due to the lack of preservative. For each subsequent application, reveal a new bottle of ICRIFINIZINA BK.

To open the bottles of Inesifirodium and Izifirin BC or cut off with scissors the upper part of the beam of the bottle, or the hole is poured in it with a thick needle. The best option is to do the hole with a needle, since in this case it is much easier to dose the drug dropparts much easier and more convenient than with a large hole formed by cutting the tip of the bottle with scissors.

Solutions IRFRINIRINA are injected into the eyes as follows:
1. Raise your head up thus so that the face looks into the ceiling;
2. Neatly fingers pull out the lower eyelid so that a small conjunctival bag is formed between it and the surface of the eye;
3. Take a bottle with drops and turn it off with a dropper (top tip) down, while keeping the tip is straight over the surface of the eye at a distance of 2 - 4 cm;
4. Then press the vial to the bottle, so that only one drop of the solution is squeezed out of it;
5. Alternately make a solution in both eyes;
6. After instillation of the solution, it is easy to lie or sit, you cannot read, watch TV, write and make any other actions, straining eyes.

At the time of the instillation, it is necessary to follow the tip of the dropper of the bottle of IRFRINIRINA not touching the mucous membrane of the eye. If this happened, it is necessary to throw the packaging of the drug and to open the new bottle for the next instillation. When the drop of the solution falls on the mucous membrane and rolls into a conjunctival bag formed by the drawn lower eyelid, it is necessary to press the fingers to internal corner Eyes for a few seconds, which will allow the solution to quickly absorb tissue and reduce the severity of the reflex desire to close the eye.

Solutions IRFRINRINI BK and ICRIRIN 2.5% or 10% apply to the following schemes and rules:

For the production of ophthalmoscopy Using 2.5% I am I and I and I and BC. Any chosen solution is made in one drop in each eye and expect about 15 to 30 minutes to a pronounced expansion of the pupil, after which an ophthalmic study is produced. If it is necessary to hold the pupil in a highly advanced state for a long time, then in an hour it is possible to enter the eyes in another drop of solution. If the pupil expands not strongly or there is an excessive pigmentation of the iris, then an adult or children over 12 years old for the production of ophthalmoscopy can be buried a 10% solution of iR-infinity in the same dose (one drop in each eye).
To eliminate accommodation spasms Using 2.5% I am I and I and I and BC. Children over 6 years old and adults are brought daily on one drop of solution in every eye overnight for 4 weeks. If the accomplication spasm is resistant and does not give in to therapy with 2.5% solution or IF BC, then children over 12 years old and adults can be corned in the eye of 10% of ICF. In such cases, the IP solution of 10% is made on one drop in each eye before bedtime daily, within 2 weeks.
For provocative test If the closed gloom is suspected, 2.5% of ICF or ICRIRIR BC are used. At the same time, the intraocular pressure is measured before the use of IPness, and after some time after making droplets into the eye. If the difference between the intraocular pressure values \u200b\u200bbefore and after the expansion of the pupil is 3 - 5 mm RT. Art., The provocative test is considered positive, and glaucoma is confirmed. With any other difference between the pressure values \u200b\u200bbefore and after the expansion of the pupil, the test is considered negative, and glaucoma is excluded from the list of suspected diseases.
For distinction (Differential diagnosis) surface and deep injection of the eyeball Intrinine drops are used 2.5% or ICRIRINA BC. To conduct a study, each eye is buried on one drop of solution and wait 5 minutes, after which the result fixes. If the redness of the mucous eye is mostly disappeared, the injection of the eyeball is considered to be superficial. If redness is preserved, the injection of the eyeball is considered to be deep, which may be a sign of iridocyclitis or a scurr. Therefore, when the deep injection of the eyeball is detected, additional diagnostic manipulations should be carried out, aimed at identifying the existing, but relatively hidden illness of the eye tissue.
With iridocyclite To prevent the formation and dissolving of existing battlefires (synechs), as well as to reduce the production of inflammatory fluid, 2.5% are used, and 10% of the ICFRIN drops, and ICRIRINA BC. The solution of the assigned concentration by a concentration is made on one drop into each eye 2 - 3 times a day, up to the appearance of improvements. With this disease, the concentration of the solution Iriforina chooses a doctor. If 2.5% solution is assigned, then you can use either a regular ICF with a preservative or an ICFRINI BK. If a 10% solution is assigned, then only 10% I and I can use.
In glaucomo-cyclic crises It is optimally used by a 10% IP solution, bringing it one drop into each eye 2 - 3 times a day.
When preparing the eye to surgical operations Only 10% Icifilla should be used. The solution is made on one drop in each eye in 0.5 - 1 hour before the operation.

In all cases listed, it is possible to apply 2.5% and I and ICRIRINA BC, choosing any kind of medicinal preparation solely on the basis of personal preferences. However, in addition, there are several situations that show and recommended the use of exclusively IRFINIRINA BC without preservative.

So, IRFRINRINI BC is recommended for use in the following cases:

Prevention of accommodation spasm in children school agesuffering from myopia (myopia) weak degree - IRFRINRINI BC brought one drop into each eye before bedtime daily, during the entire period of high experiences on the eyes.
Prevention of accommodation spasms in school age children suffering from progressive myopia middle degree Gravity - ICRIRINRINI BK brought into each eye one drop 3 times a week before bedtime, for a long time.
The prevention of the accommodation spasm in the period of high loads on the eyes in people of any age, having normal vision - the IRFRINIR BC is brought into the eyes of one drop during the daytime at the time of intensive eye load. In this case, the drops are used as needed for an unlimited period of time.
Prevention of spasmodation spasm in people of any age suffering from hyperamerropy (hyperopiasis) - in the period of high loads, IRFRINRINI BK is brought over one drop in each eye before bedtime daily, in combination with 1% cyclopentolate solution. In the period of ordinary or medium loads on the eyes, the IRFRINIR BC is brought one drop in the evening, three times a week.
Treatment of false and true myopia (myopia) - to make 1 drop of Izifirin BC in each eye in the evening before bedtime 2 - 3 times a week, within a month.

As can be seen, the IRFRINIRI of the BC is preferable for routine use in people suffering from myopia or hypermetropy, in order to maintain the normal functioning of the eyes and prevent the accommodation spasm (the state when a person cannot see the objects away after a long focus of the look at closely located things, and vice versa) . Also, IRFRINIR BK is used in complex therapy Myopia in people of different ages and gender, and therefore this drug often prescribe schoolchildren.

After Irifirch

Immediately after making drops, the Ines of any concentration and varieties in the eye appears an unpleasant discomfort of burning sensation or cookies. However, this feeling quickly passes (within a few seconds), and the eyes becomes much easier. After making drops at least within 2 - 3 hours, it is impossible to strain your eyes in any way, that is, read, write, watch TV, etc.

After about 15 - 20 minutes after the instillation of the solution, the pupil becomes highly expanded, as a result of which the vision worsens, all objects become blurred, fuzzy, etc. In addition, the bright light is very annoying his eyes. Such a condition is preserved for several hours, and that is why drops are recommended to use on the night so that the period of blurred visibility fell on the inactive part of the day.

In people who suffer from hypertension, a few minutes after making a drop of Irifirin in the eye, arterial pressure can increase. It is necessary to be morally ready and not frightened to such a turnover, since the pressure is normalized after some time after the increase.

During the entire period of use of the IP drops, it is necessary to wear only glasses, you should refuse from contact lenses. You can again apply contact lenses only after 3 to 4 days after the completion of the application of IPness.

After completing the application of IP, another 1 - 3 days, vision remains fuzzy, muddy, etc. But this effect passes, and vision, on the contrary, becomes better than before applying the drug. Regular use of droplets eliminates pain and cuts, reduces redness in the eyes, they are less tired, visual acuity is practically not reduced by evening, etc. Many people whose acuity of vision is slightly lower than the norm, the Intriforgic Course allows you to improve it so much that the need for glasses wearing disappears.

Application during pregnancy and breastfeeding

Research on the study of the effect of the drug on the fruit and the course of pregnancy was not carried out, so there are no reliable data on the safety of IPness for women who carry or nursing the child. By virtue of this situation, doctors are recommended to refrain from the use of IPness during pregnancy and breastfeeding. If for some reason a woman needs therapy with IF, then during pregnancy and breastfeeding it can be used only if the intended benefits exceeds all possible risks.

special instructions

The introduction of 2.5% ICRIRINA or ICRIPITRINA BC in an amount of more than two drops into each eye at a time can lead to reinforced absorption of the drug in the bloodstream and, accordingly, the development of systemic side effects. This risk is available in all people, but it is especially high in patients after injury or operation in the eyes, with reduced production of tear fluid and with eye diseases (except myopia and hypermetropy).

ICFILIN should be used with caution in people suffering from diabetes, as well as in the elderly (over 65 years old). The fact is that during diabetes, there is a high risk of increasing blood pressure in response to the introduction of droplets of ICF in the eye, and in the elderly, the high probability of the reactive sharpness of the pupil instead of expansion.

As I and Fifirin can provoke hypoxia conjunctiva, the drug must also be used with caution in people wearing contact lenses that suffer from sickle cell anemia or experienced eye operation.

In addition, it should be combined to combine the use of ICRIFIRINA with the reception of drug-inhibitors of Mao (for example, solegilin, ironymide, nialamide, phenelzine, tralylsipromine, pylindol, ebrobhemid, etc.). Optimally disseminate the use of ICRIFIRINA and MAO inhibitors for 21 days. That is, it is necessary to start the use of IRFINIRINA 18 day after completing the course of treatment in inhibitors of Mao and, respectively, on the contrary.

Overdose

An overdose of IFF is possible, and is manifested by the development of the system action of alpha adrenomimetics, namely: a sharp increase in blood pressure, dryness and irritation in the mouth and the nasal cavity, reflex tachycardia (heart rate of more than 70 blows per minute) or bradycardia (heart rate below 50 strikes per minute).

Alpha-adreneroblasts are used to eliminate overdose, for example, fantolamine in an amount of 5-10 mg. The fantolamine solution is administered intravenously, focusing on the magnitude of the pupil. As soon as the pupil starts to be suspended, the introduction of the antidote is stopped and the treatment of overdose is considered complete.

Impact on the ability to manage mechanisms

Within a few hours after entering the eyes, Intriforin causes impairment. Therefore, if the drug is used during the daytime, it should be abandoned from any activity that requires high speed of reactions and concentration of attention. If the drops are applied overnight before bedtime, then in the daytime it is quite possible to engage in any kind of activity, including controlling mechanisms, since ICFRIN does not affect the speed of psychomotor reactions.

Interaction with other medicines

The effect of the expansion of the pupil is enhanced when IP is used with atropine. In addition, this combination of drugs can provoke the development of tachycardia (the pulse is more than 70 shots per minute).

The simultaneous use of IPness with Mao inhibitors (for example, an ironiazide, nialamide, phenylsine, tralylsipromine, pylindol, tetrindol, moklobemoid, etc.) can provoke an uncontrolled increase in blood pressure. Such a danger is maintained at the beginning of the use of ICRIFIRIN in less than 21 days after the completion of the course of treatment in Inhibitors of MAO. Therefore, in order to avoid the risk of uncontrolled pressure increase, it should be used by ICFRIN in 21 days after the end of the reception of Mao inhibitors.

Combined use of IPness with tricyclic salbutamol, etc.) can enhance the vasoconstrictor effect of the IP.

Icifilla for children

In children of different ages, including pre-school or younger school, I and FRINIRIN, as a rule, are used to treat myopia or hyperopia, as well as to prevent deterioration in visual acuity, eliminating eye fatigue against the background of high or medium loads.

For the treatment of myopia or hyperopia, the drops are prescribed with courses lasting one month, which are carried out 1 - 2 times a year. Usually, 2.5% of ICF or ICRIRIN BC are prescribed, which make 1 drop in each eye before bedtime daily, or 2 drops in each eye over the night every other day. As a rule, in such cases, ICFRINIR is used in a complex with a tauphon, an emoxipin or other similar eye drops. Regular use of IRFRINIRINA at myopia or hyperopia allows you to maintain visual sharpness at the current level and prevents "drop", that is, impairment of vision.

In addition, very often I and Fortyrin are prescribed to children who collided with impairment of vision, with strong fatigue and redness of the eyes against the background of high loads at school, circles, etc. In such cases, it is recommended to use IC 2.5% or ICF BC, bringing into each eye on one drop daily before bedtime, within a month. After completing the course of use, the IRFRINIRINI of the eye in children cease to be tired strongly, they do not blush, they do not hurt and do not get drunk, and the acuity of vision is often increasing or even restored to the norm. Thanks to the use of ICRIFIRIN in the "drop" of vision in children, in many cases, it is possible to stop the pathological process and postpone the beginning of the wearing points.

Side effects

The entire totality of the side effects of Irifirod is divided into local and systemic. Local side effects are developing directly in the eye, and do not concern other organs and body systems. Side effects are developing in the absorption of the drug in the bloodstream, and are characterized by its impact on various internal organs. Typically, systemic side effects develop when using high dosages of the drug, especially 10% of IRFINIRINA.

Local side effects IRFINIRINA These are:

Periorbital swelling;
The feeling of burning in the eyes immediately after the instillation (especially strongly expressed at the beginning of use, but decreases in approximately 1 to 2 weeks of use of drops);
Blurred vision;
Irritation in the eyes;
Feeling of discomfort in the eyes;
An increase in intraocular pressure;
Reactive miosis (sharp narrowing of the pupil) the day after the use of droplets;
The appearance of the front camera of the pigment particles from the rainbow shell is 30 - 45 minutes after the use of droplets.

System Side Effects Incentive Intrinitsa:

Contact dermatitis;
Student heartbeat (tachycardia);
Bradycardia (heart rate of less than 50 shots per minute);
Arrhythmia;
An increase in blood pressure;
Sharp narrowing of coronary (heart) arteries;
Myocardial infarction, vascular collapse or intracranial hemorrhage (develop very rarely and only when using 10% IMIFIRIN).

Contraindications for use

Drops I and Fashion Both varieties and concentrations contraindicated to use If a person has the following diseases or states:

Individual increased sensitivity or allergic reactions on the components of the drug;
Narrow-coronal or closed glooma;
Age older than 65 years old in the presence of severe diseases of the cardiovascular and cerebrovascular system;
Condition after operations in people with impaired integrity of the eyeball or with reduced products of tear fluid;
Hepatic porphyria;
Congenital deficiency of glucose-6-phosphate dehydrogenase;
Age under 12 years old (only for 10% solution);
Aortic aneurysm (only for 10% solution);
Premature children.

Moreover, caution should be used Capples of ICF in the following diseases and from states:

Diabetes Type II;
Age older than 65 years;
Babies under 1 year;
Simultaneous reception of Mao inhibitors and 21 days after their application;
The constant wearing of contact lenses with the inability to replace them with points for the period of use of the drug;
Status after eye operations.

Analogs

Analogs of Izifirin is divided into two varieties - these are synonyms and, in fact, analogues. Synonyms include drops, which also contain phenylephrine as an active substance. Analogues of Inesifirits include drugs that have a similar therapeutic effect, but contain other active ingredients.

The synonyms are the following drugs:

Visofrine Eye drops;
Meston eye drops;
Neosinephrin-pos drops Eye.

With some part of the convention to analogues can be attributed vaconishing drugsdesigned to treat redness and eye fatigue:

Allergeft;
Nafazolin;
Oxymetazoline;
Surpellerg;
Tetrisoline.

Cheap analogues of Izifirin

All synonyms Ines are cheaper. So, Meston in pharmacies are sold at 38 - 54 rubles per vial, Visofrin - 120 - 280 rubles, non-Sinephrine-Pos - 95 - 210 rubles.

Cheaper analogues are visiting, oxymetazoline and tetrisoline.

The active substance of the drug IRFRINRIN - phenylephrine, affecting specific structures nervous system, vessels, hearts. Thanks to this property, the narrowing of the vessels occurs, the swelling is reduced, the pupil of the eye (mydriasis) is expanding without disrupting the production of moisture of the front chamber of the eye.

The effect of the drug begins for 2 minutes, therapeutic effect Saves from 2 to 7 hours (depending on the concentration of the solution).

The composition of IPness (in 1 ml):
There are 2 forms of drug - 2.5% or 10% phenylephrine solution with inactive components (sodium chloride, etc.).

Instructions for use Inesifirina:

with iridocyclitis - 2.5% (contraindicated children with a body weight deficit) or 10% (children under 12 years old are contraindicated) a solution of 1 drop in each eye 2-3 times a day;
to reduce the WGD, a 10% solution is used - 1 drop 3 times a day;
to diagnose eye disease - 2.5% solution of phenylephrine is prescribed once;
before prompt interventions - 10% solution 1 time half an hour - an hour before the operation.

The method of application of IPness and its dosage during the course of treatment is controlled by a doctor!

The method of application and dosage of IRFINIRINA with repeated courses of treatment controls the doctor!

Contraindications for appointment Incenter:

treatment of certain types of glaucoma (narrow - and indoor);
intolerance to the components of the drug;
reduced function thyroid gland (hypothyroidism);
hemoglobin metabolism;
older people with diseases of the blood vessels and brain (atherosclerosis, IBS, etc.).

Side effects Izifirin

Side effects Irifirin are discharged to local and common.

midship and persistent increase in vgd; The feeling of burning, sand in the eye, local allergies, vision of vision. It is possible to develop across the day of the pronounced reactive narrowing of the pupil (MIOS).

Common effects:

nausea, headache, trembling of hands, insomnia, dizziness, increased blood pressure, arrhythmia, extremely rarely infarction, stroke.

When the drug is overdose, listed side effects are observed, but more pronounced. In such cases, it is immediately to stop the use of medicine, rinse the eye by the conjunctive, consult a doctor.

There is no data about the change in the efficiency of IRFINIZY after taking alcohol.

Addictive to the drug is not marked.

Manufacturer - Promed Exports Pvt. Ltd.

The release form is 2.5% or 10.0% solution in a bottle with a dropper (or a bottle-dropper) - 5ml.

The shelf life of the drug or analogues of IRFINIRINA after opening the bottle - up to 30 days; In the undisturbed package - 2 years.

Just like Drops "Quinaks", I and Farrin is released from a pharmacy for a doctor's prescription. Numerous reviews about this preparation you can find on the Internet. And your feedback can be left in our section "Blogs".

it is an ophthalmological drug used locally (

drops in the eyes) and the following effects: the expansion of the pupil, the improvement of the outflow of intraocular fluid and the suspension of the vessels of the conjunctival shell. Eye drops Icifirin are used at

iridocyclite

to reduce the amount of separated iris, with glaucomo-cyclic crises, during syndrome

red eyes

Accommodation spa, as well as to expand the pupil during operations and preoperative preparation.

Otherwise, there is no any difference in the composition or therapeutic effect between Irifirin or Izifino. In use, both varieties of the drug are usually united under one common name "I IZFINRIN", only if necessary, it is detailed and indicating what kind of drug variant are we talking about. In the future text of the article, we will also be both varieties of the drug called Irifirine, indicating the exact name only if necessary, emphasize attention on any specific properties inherent in one or another kind of medication.

I and FRIRINA and ICRIRINRIRI BC are produced in a single dosage form - these are drops for the eyes. As an active substance drops contain phenylephrin In various dosages. Thus, the ICFRIN drops are produced in two dosages - in the form of 2.5% and 10% solution. And the IRFRINIRI of the BC is available only in the form of a 2.5% solution. Intrinine 2.5% and IRFRINIR BK contain 25 mg of phenylephrine in 1 ml of solution. Accordingly, I and Finigine 10% contains 100 mg of phenylephrine in 1 ml of solution.

Excipients Both varieties of ICRIFIRINA are reflected in the table.

The active substance of Irifirod Phenylephrine is an alpha adrenomimetic, respectively, has an impact on the smooth muscles of blood vessels. When using phenylephrine in the form of eye drops, the drug affects only the vessels of this organ. If phenylephrine is introduced intravenously or subcutaneously, it has an impact on all vessels in the human body, as well as on

Application of droplets Irifirin on the mucous membrane of the eye causes an expansion of the pupil, enhances the outflow of intraocular fluid, and also narrows the blood vessels of conjunctiva. The narrowing of the vessels of the conjunctiva ensures the disappearance of redness of the eye, as a result of which the drug is used in the therapy of the "Red Eye" syndrome. Strengthening outflow of intraocular fluid provides an improvement in the condition of the eye when glauer. And the expansion of the pupil caused by the IP drops is used to preoperative preparation or in the process of conducting surgical intervention in the eyes.

Roplets of ICFRIN and ICFRINIR BC of various concentrations are shown to use in the same following cases:

Reducing the number of inflammatory separated iris shell and preventing the formation of synechs (battles) with iridocyclite (inflammation of the iris or ciliary body of the eye);
To distinguish the surface and deep injection of the eyeball;
To carry out a provocative test, which allows you to confirm or, on the contrary, reject suspicion of the closed gloom in people with a narrow angle of the front chamber of the eye;
Expansion of the pupil when conducting diagnostic procedures, such as ophthalmoscopy, monitoring the state of the rear segment of the eye, etc.;
As a means for preoperative preparation for the expansion of the pupil (only for 10% drops);
To expand the pupil in the production of laser surgical operations on the eye day (for example, laser correction vision, etc.) - optimal 10% drops;
To expand the pupil in the production of manipulations of vitreoretinal surgery (optimal 10% drops);
Treatment of glaucomous-cyclitic crises (optimal 10%);
Treatment of "Red Eye" syndrome (only 2.5% drops of ICFRIR or ICRIRINIR BK);
The elimination and treatment of spasmodation spasm, which is also called false myopia (spasm of the ciliary muscle of the eye, which occurs during a long focusing and holding a look at any or closely located subjects, as a result of which the body is overwhelmed, and a person loses normal visual sharpness for it near or in the distance).

If in brackets next to the indication it is indicated that it is only for droplets of one or another concentration, then it should be used in the presence of this state or illness of an exclusively meaning an iphirin version. If the "optimal" drops of any concentration are indicated in brackets next to the indication, then this means that this condition is suitable for these states, but others can also be used.
General provisions

I am 2.5% IC drops and 10%, as well as IRFRINRINIR BK applied according to the same rules. Choosing a variety of drops (IRFRINIR or ICF) depends mainly, from a preservative man tolerability -

benzalconium chloride . This means that if a person normally transfers this preservative (for example, in the past, droplets containing the same preservative), it can choose any type of drug, proceeding exclusively from personal, subjective preferences (for example, packaging any species like more and etc.) If a person does not tolerate a preservative, then he needs to use drops ICFRI BK.

To open the bottles of Inesifirodium and Izifirin BC or cut off with scissors the upper part of the beam of the bottle, or the hole is poured in it with a thick needle. The best option is to do the hole with a needle, because in this case it is much easier to dose the drug in the drops of drops is much easier and more convenient than with a large hole formed by cutting the tip of the bottle with scissors.

Solutions IRFRINIRINA are injected into the eyes as follows:

1. Raise your head up thus so that the face looks into the ceiling;

2. Neatly fingers pull out the lower eyelid so that a small conjunctival bag is formed between it and the surface of the eye;

3. Take a bottle with drops and turn it off with a dropper (top tip) down, while keeping the tip is straight over the surface of the eye at a distance of 2 - 4 cm;

4. Then press the vial to the bottle, so that only one drop of the solution is squeezed out of it;

5. Alternately make a solution in both eyes;

6. After instillation of the solution, it is easy to lie or sit, you cannot read, watch TV, write and make any other actions, straining eyes.

At the time of the instillation, it is necessary to follow the tip of the dropper of the bottle of IRFRINIRINA not touching the mucous membrane of the eye. If this happened, it is necessary to throw the packaging of the drug and to open the new bottle for the next instillation. When a drop of solution falls on the mucous membrane and rolls into a conjunctival bag formed by the drawn lower eyelid, it is necessary to put pressure on the inner angle of the eye for a few seconds, which will allow the solution to quickly absorb the tissue and reduce the severity of the reflex desire to close the eye.

Solutions IRFRINRINI BK and ICRIRIN 2.5% or 10% apply to the following schemes and rules:

For the production of ophthalmoscopy Using 2.5% I am I and I and I and BC. Any chosen solution is made in one drop in each eye and expect about 15 to 30 minutes to a pronounced expansion of the pupil, after which an ophthalmic study is produced. If it is necessary to hold the pupil in a highly advanced state for a long time, then in an hour it is possible to enter the eyes in another drop of solution. If the pupil expands not strongly or there is an excessive pigmentation of the iris, then an adult or children over 12 years old for the production of ophthalmoscopy can be buried a 10% solution of iR-infinity in the same dose (one drop in each eye).
To eliminate accommodation spasms Using 2.5% I am I and I and I and BC. Children over 6 years old and adults are brought daily on one drop of solution in every eye overnight for 4 weeks. If the accomplication spasm is resistant and does not give in to therapy with 2.5% solution or IF BC, then children over 12 years old and adults can be corned in the eye of 10% of ICF. In such cases, the IP solution of 10% is made on one drop in each eye before bedtime daily, within 2 weeks.
For provocative test If the closed gloom is suspected, 2.5% of ICF or ICRIRIR BC are used. At the same time, the intraocular pressure is measured before the use of IPness, and after some time after making droplets into the eye. If the difference between the intraocular pressure values \u200b\u200bbefore and after the expansion of the pupil is 3 - 5 mm RT. Art., The provocative test is considered positive, and glaucoma is confirmed. With any other difference between the pressure values \u200b\u200bbefore and after the expansion of the pupil, the test is considered negative, and glaucoma is excluded from the list of suspected diseases.
For distinction (Differential diagnosis) surface and deep injection of the eyeball Intrinine drops are used 2.5% or ICRIRINA BC. To conduct a study, each eye is buried on one drop of solution and wait 5 minutes, after which the result fixes. If the redness of the mucous eye is mostly disappeared, the injection of the eyeball is considered to be superficial. If redness is preserved, the injection of the eyeball is considered to be deep, which may be a sign of iridocyclitis or a scurr. Therefore, when the deep injection of the eyeball is detected, additional diagnostic manipulations should be carried out, aimed at identifying the existing, but relatively hidden illness of the eye tissue.
With iridocyclite To prevent the formation and dissolving of existing battlefires (synechs), as well as to reduce the production of inflammatory fluid, 2.5% are used, and 10% of the ICFRIN drops, and ICRIRINA BC. The solution of the assigned concentration by a concentration is made on one drop into each eye 2 - 3 times a day, up to the appearance of improvements. With this disease, the concentration of the solution Iriforina chooses a doctor. If 2.5% solution is assigned, then you can use either a regular ICF with a preservative or an ICFRINI BK. If a 10% solution is assigned, then only 10% I and I can use.
In glaucomo-cyclic crises It is optimally used by a 10% IP solution, bringing it one drop into each eye 2 - 3 times a day.
When preparing the eye to surgical operations Only 10% Icifilla should be used. The solution is made on one drop in each eye in 0.5 - 1 hour before the operation.

In all of the above cases, it is possible to apply 2.5%, and ICFRI BK, choosing any kind of medicinal drug solely on the basis of personal preferences. However, in addition, there are several situations that show and recommended the use of exclusively IRFINIRINA BC without preservative.

The prevention of the accommodation spasm in school age children suffering from myopia (myopia) of a weak degree - IRFRINIR BC brings one drop in each eye before bedtime daily, during the entire period of high experiences on the eyes.
The prevention of accommodation spasms in children of school age suffering from the progressive myopia of the moderate severity - IRFRINRINI BC is introduced into each eye on one drop 3 times a week before bedtime, for a long time.
Prevention of accommodation spasm in the period of high loads on the eyes in people of all ages having normal vision - IRFRINRINA BC brought into the eyes of one drop during the daytime at the time of intense eye load. In this case, the drops are used as needed for an unlimited period of time.
Prevention of spasmodation spasm in people of any age suffering from hyperamerropy (hyperopiasis) - in the period of high loads, IRFRINRINI BK is brought over one drop in each eye before bedtime daily, in combination with 1% cyclopentolate solution. In the period of ordinary or medium loads on the eyes, the IRFRINIR BC is brought one drop in the evening, three times a week.
Treatment of false and true myopia (myopia) - to make 1 drop of Izifirin BC in each eye in the evening before bedtime 2 - 3 times a week, within a month.

As can be seen, the IRFRINIRI of the BC is preferable for routine use in people suffering from myopia or hypermetropy, in order to maintain the normal functioning of the eyes and prevent the accommodation spasm (the state when a person cannot see the objects away after a long focus of the look at closely located things, and vice versa) . Also, ICRIRINIR BK is also used in the complex therapy of myopia in people of different ages and gender, and therefore this drug is often prescribed to schoolchildren.

Research on the study of the effect of the drug on the fruit and the course

pregnancy

it was not carried out, therefore, any reliable data on safety ICRIPIRINA for women who carry or nursing the child is not. By virtue of this situation, doctors are recommended to refrain from the use of IPness during pregnancy and

breastfeeding

If for some reason a woman needs therapy with IF, then during pregnancy and breastfeeding it can be used only if the intended benefits exceeds all possible risks.

or operations in the eyes, with a reduced formulation of the tear liquid and

eye diseases

(except myopia and hypermetropy).

As I and Fifirin can provoke hypoxia conjunctiva, the drug must also be used with caution in people wearing contact lenses that suffer from sickle cell anemia or experienced eye operation.

Overdose by IFF is possible, and manifests itself by the development of the system action of alpha adrenomimetics, namely: a sharp increase

arterial pressure

and irritation in the mouth and nasal cavity, reflex

tachycardia

(cardiac frequency of more than 70 shots per minute) or

bradycardia

(cardiac frequency is below 50 shots per minute).

Within a few hours after entering the eyes of IRFrigin causes

worsening vision

Therefore, if the drug is used during the daytime, it should be abandoned from any activity that requires high speed of reactions and concentration of attention. If the drops are applied overnight before bedtime, then in the daytime it is quite possible to engage in any kind of activity, including controlling mechanisms, since ICFRIN does not affect the speed of psychomotor reactions.

The effect of the expansion of the pupil is enhanced when IP is used with

Atropine

In addition, this combination of drugs can provoke the development of tachycardia (the pulse is more than 70 shots per minute).

Combined use of IPness with tricyclic antidepressants (for example, amitriptyline, imipramine, doxypine, trazodon, etc.), propranolol, reserpine, guanethidine, methyldop and m-cholinoblockers (for example, atropine, platifilin, and tropical, tropiacal, trihexiphenidyl, etc.) can cause A sharp increase in blood pressure and reflex bradycardia (pulse less than 50 shots per minute) or tachycardia.

Caps of I am I amifirging 10% in combination with beta-adrenoblockers (for example, pindolol, bopindolol, oxprenolol, propranolol, supolyol, thymolol, labetalol, atenolol, bisoprolol, etc.) can provoke hypertensive crisis or a sharp increase in blood pressure.

Sympathomimetics (for example, ephedrine, adrenaline, isoprenaline, phenooterol, salbutamol, etc.) can enhance the vasoconstrictor effect of IRFRINIRINA.

For the treatment of myopia or hyperopia, the drops are prescribed with courses lasting one month, which are carried out 1 - 2 times a year. Usually, 2.5% of ICF or ICRIRIN BC are prescribed, which make 1 drop in each eye before bedtime daily, or 2 drops in each eye over the night every other day. As a rule, in such cases, ICFRINIR is used in a complex with a tauphon, an emoxipin or other similar eye drops. Regular use of IRFRINIRU in myopia or hyperopia makes it possible to maintain visual sharpness and prevents "drop", that is, impairment of vision.

In addition, very often I and Fortyrin are prescribed to children who collided with impairment of vision, with strong fatigue and redness of the eyes against the background of high loads at school, circles, etc. In such cases, it is recommended to use IC 2.5% or ICF BC, bringing into each eye on one drop daily before bedtime, within a month. After completing the course of use, the IRFRINIRINI of the eye in children cease to be tired strongly, they do not blush, they do not hurt and do not get drunk, and the acuity of vision is often increasing or even restored to the norm. Thanks to the use of ICRIFIRINA when "dropping" of vision in children, in many cases, it is possible to stop the pathological process and postpone the start of the wearing points.

The entire totality of the side effects of Irifirod is divided into local and systemic. Local side effects are developing directly in the eye, and do not concern other organs and body systems. Systemic side effects are developing in the absorption of the drug in the bloodstream, and are characterized by its impact on various internal organs. Typically, systemic side effects develop when using high dosages of the drug, especially 10% of IRFINIRINA.

Local side effects IRFINIRINA These are:

Conjunctivitis;
Periorbital swelling;
The feeling of burning in the eyes immediately after the instillation (especially strongly expressed at the beginning of use, but decreases in approximately 1 to 2 weeks of use of drops);
Blurred vision;
Irritation in the eyes;
Feeling of discomfort in the eyes;
Tear;
An increase in intraocular pressure;
Reactive miosis (sharp narrowing of the pupil) the day after the use of droplets;
The appearance of the front camera of the pigment particles from the rainbow shell is 30 - 45 minutes after the use of droplets.

System Side Effects Incentive Intrinitsa:

Contact dermatitis;
Student heartbeat (tachycardia);
Bradycardia (heart rate of less than 50 shots per minute);
Arrhythmia;
An increase in blood pressure;
Sharp narrowing of coronary (heart) arteries;
Embolism of the pulmonary artery;
Myocardial infarction, vascular collapse or intracranial hemorrhage (develop very rarely and only when using 10% IMIFIRIN).

Individual increased sensitivity or allergic reactions to the components of the drug;
Narrow-coronal or closed glooma;
Age older than 65 years old in the presence of severe diseases of the cardiovascular and cerebrovascular system;
Condition after operations in people with impaired integrity of the eyeball or with reduced products of tear fluid;
Hyperthyroidism;
Hepatic porphyria;
Age under 12 years old (only for 10% solution);
Aortic aneurysm (only for 10% solution);
Premature children.

Moreover, caution should be used Capples of ICF in the following diseases and from states:

Type II diabetes;
Sickle cell anemia;
Age older than 65 years;
Babies under 1 year;
Simultaneous reception of Mao inhibitors and 21 days after their application;
The constant wearing of contact lenses with the inability to replace them with points for the period of use of the drug;
Status after eye operations.

The synonyms are the following drugs:

Visofrine Eye drops;
Meston eye drops;
Neosinephrin-pos drops Eye.

With some part of the convention, the following vasoconstrictors intended for the treatment of redness and eye fatigue can be attributed to the analogues.

Allergeft;
Visiting;
Nafazolin;
Oxymetazoline;
Surpellerg;
Tetrisoline.

Cheaper analogues are visiting, oxymetazoline and tetrisoline.

Most of the reviews (more than 80%) on the use of IRFIRINIRS are positive, due to high efficiency drug and fairly fast appearance of clinical improvements. In responses it is indicated that after the use of IRFINIDIN in many cases, visual acuity has improved (which was confirmed by the data of optometry), the eyes were less tired, the feeling of burning or cutting after hard work was disappeared (for example, by a computer, with papers, etc.), as well as Fully passed redness. Thanks to such effects, the quality of life has increased significantly, because a person could safely work even hardly straining his eyes, and not suffer from cutting,

Burning and redness in them.

People suffering from myopia or farewell, in responses noted that regular applications of IRFRINIRINA allow you to maintain visual acuity at the same level without letting it decrease.

Negative feedback on the use of IMIFINIRINA is a bit, and they are usually due to the development of side effects or intolerance to the drug. There are literally single negative feedback due to the absence of the expected effect from the use of the drug.

The overwhelming majority of reviews about Izifirine children are positive. Children I am as a rule appointed with severe eye fatigue and associated with this worsening of visual acuity arising against the background of high loads at school or in developing circles. In addition, ICF is used in complex treatment Children who are already suffering from myopia or farewell.

In responses, it is noted that the use of droplets at the fatigue of the eye led to an improvement in visual acuity, which allowed the child not to wear glasses. In addition, the eyes stopped blundering, swollen, root and get pathored even after a long load.

In response concerning the use of IRFRINIRIN in myopia or hyperopia, it is indicated that the drug supports visual sharpness and does not make it deteriorating, and in some cases it even improves it.

In addition, the reviews indicate that ICRIRINIRIN highly effectively prevents the accommodation spasm (the inability to distinguish the items located near, after a long focus of the view on distant objects, or vice versa) in children with any urgency of vision (normal, myopia or diagnosticity) experiencing high loads On the eyes, which allows them to learn better and not to get tired.

There are practically no negative feedback on the use of IRFIRINIZ in children, since even the unpleasant sensations arising immediately after instilcing the solution in the eyes, the kids are postponed and quite adequately, realizing that treatment is necessary. In addition, the effect of the application of IPness is noticeable, and adverse reactions Practically do not arise.

Currently, the cost of Cappets I ISFRINIR AND ICRIRINIR BK in pharmacies of the cities of Russia fluctuates within the following limits:

ICRIRINIRI BK 2.5%, 15 drops of drops of 0.4 ml - 450 - 549 rubles;
Intrinine 2.5%, vial 5 ml - 342 - 449 rubles.

When purchasing a drug, it is necessary to pay attention to the shelf life, which is 2 years, counting from the date of manufacture, provided that the bottle is hermetically packed and never revealed. An open bottle can be stored no longer than one month. Store IRFIRIN is necessary in a dark place at an air temperature not higher than 25 ° C.

If the drug will be stored in improper conditions, it can lose its properties and its application will not bring any positive therapeutic effect.

Indications for the use of the drug IAFRIN

expansion of the pupil with ophthalmoscopy and other diagnostic procedures necessary to control the state of the rear segment of the eye;

conducting a provocative test in patients with a narrow profile of an angle of the anterior chamber and suspicion of the closedian glaucoma;

differential diagnosis type of injection of the eyeball;

in ophthalmosurgery in preoperative preparation for expanding the pupil (10% solution);

when conducting laser interventions on the eye day and vitreo-retinal surgery;

treatment of glaucomocyclothic crises;

treatment of "Red Eye Syndrome" (2.5% solution) (to reduce hyperemia and irritability of the shells of the eye).

The release form of the drug IAFRIN

eye drops 10%; bottle (bottle) of dark glass 5 ml with dropper, pack cardboard 1;

eye drops 2.5%; bottle (bottle) of dark glass 5 ml with dropper, pack cardboard 1;

eye drops 10%; Bicon-dropper plastic 5 ml, tutu cardboard 1;

eye drops 2.5%; Bicon-dropper plastic 5 ml, tutu cardboard 1;

Eye drops 2.5% 1 ml

phenylephrina hydrochloride 25 mg

benzalconium chloride 0.1 mg

Eye drops 10% 1 ml

phenylephrine 100 mg

benzalconium chloride 0.1 mg

excipients: boric acid; sodium metabisulphite anhydrous; Diodatrial salt of ethylenediaminetetraacetic acid; sodium phosphate is unanimous; sodium phosphate double-sufficient anhydrous; sodium hydroxide and / or chloride hydrochloric acid; water for injections

in dark glass bottles with a dropper of 5 ml; In a pack of cardboard 1 bottle.

Pharmacodynamics of Izdigin Pharmacodynamics

Phenylephrine - sympathomimetics. It has pronounced alpha adrenergic activity and when applied in conventional doses does not have a significant stimulating effect on the CNS.

Phenylephrine has a pronounced stimulating effect on postsynaptic alpha-adrenoreceptors, has a very weak effect on the beta-adrenoreceptors of the heart. The drug has a vasoconstrictor action similar to the action of norepinephrine (norepinephrine), while it has practically no chronotropic and inotropic effect on the heart. The vasopressor effect of phenylephrine is weaker than that of norepinephrine, but is longer.

After instillation, phenylephrine reduces the pupil dilator and the smooth muscles of the arteriol conjunctiva, thereby causing the expansion of the pupil. The size of the pupil is returned to its original state for 4-6 hours. Since phenylephrine has a slight impact on the ciliary muscle, mydriasis occurs without cyclopellegia.

Phenylephrine easily penetrates into the fabric of the eye, the expansion of the pupil occurs within 10-60 minutes after one-time instillation. Midships persist for 4-6 hours.

Due to the considerable reduction in the dilator of the pupil, after 30-45 minutes after the instillation in the wicking of the anterior chamber, the eyes can be detected by pigment particles from the Rainbow Shell. Silence in chamber moisture must be differentiated with uveitual manifestations either with the presence of uniform elements of blood in the moisture of the anterior chamber.

Using the drug ICFRIN during pregnancy

Since the effect of Irifirin in pregnant and nursing mothers is not sufficiently studied, the use of the drug in this category of patients is possible only if the expected effect exceeds the risk of developing possible side effects in the fetus.

increased sensitivity to the drug;

narrow-coronal or closed glooma;

elderly age in the presence of serious violations from the cardiovascular or cerebrovascular system;

additional expansion of the pupil during surgical operations in patients with impaired integrity of the eyeball, as well as in disruption of tear-products;

hyperthyroidism;

hepatic porphyria;

congenital deficiency of glucose-6-phosphate dehydrogenase;

children under 12 years old and patients with anneurysm of arteries (10% solution);

children with reduced body weight (2.5% solution).

Side effects of the drug IFF

Sensation of burning (at the beginning of use), closerness of vision, irritation, discomfort, tearing, increasing intraocular pressure, reactive mios (the day after use; At this time, the repeated instillations of drugs can give a less pronounced mydriasis than the day before; the effect is more often manifested by Elderly patients).

From the side of the cardiovascular system: rapid heartbeat, tachycardia, heart arrhythmias, incl. ventricular, arterial hypertension, reflex bradycardia, occlusion of coronary arteries, pulmonary artery embolusion, myocardial infarction (in some cases using a 10% solution in the elderly who have diseases of the cardiovascular system).

The method of application and dose of the drug IAFRINRIN

When conducting ophthalmoscopy, one-time instillations of 2.5% of the solution are used. As a rule, to create a mydriasis, it is sufficient to introduce 1 drops of 2.5% of IMIFINIRU in the conjunctival bag. The maximum mydriasis is achieved in 15-30 minutes and is maintained at a sufficient level for 1-3 hours. If it is necessary to maintain mydriasis for a long time, after 1 h re-instillation is possible.

In adults and children over 12 years old, with insufficient expansion of the pupil, as well as in patients with a rigid iris (severe pigmentation), a 10% solution in the same dosage is possible for diagnostic expansion of pupil.

For diagnostic procedures, a single instillation of 2.5% solution is used:

As a provocation test in patients with a narrow profile of an angle of the anterior chamber and a suspicion of the closedian glaucoma. If the difference between intraocular pressure values \u200b\u200bbefore injection and after expanding the pupil is from 3 to 5 mm Hg. Art., Provocative test is considered positive;

For the differential diagnosis of the type of injection of the eyeball: if 5 minutes after the instillation, the narrowing of the vascular of the eyeball is noted, the injection is classified as superficial; When preserving redness of the eye, it is necessary to carefully examine the patient for the presence of iridocyclitis or sclerite, because This indicates the expansion of deeper vessels.

With uveitis 2.5 or 10% solution is used to prevent the development and breaking of the already formed rear synechs; To reduce the exudation into the front chamber of the eye. For this purpose, one drop of the drug is buried in a conjunctival bag of a patient's eye (eye) 2-3 times / day.

In glauciclytic crises, the vasoconstrictor effect of phenylefrin has a hypotensive effect, which is more pronounced in a 10% solution. To relieve glaucomoclitic crises, 10% I and I can upload 2-3 times a day.

In preparing patients to surgical interventions 30-60 minutes before the operation, a single instillation of a 10% solution is made to achieve mydriasis. After opening the shells of the eyeball, the repeated injection of the drug is not allowed.

Overdose by Izdigin

Symptoms: A manifestation of the system action of phenylephrine is possible.

Treatment: The purpose of alpha-adrenoblocking agents, for example, from 5 to 10 mg of fantolamine V / B, can be reused if necessary.

The interactions of the drug ICFRIN with other drugs

The mydritic effect of phenylephrine is enhanced with the local application of atropine. Application of 2.5% or 10% solution with MAO inhibitors, as well as within 21 days after their cancellation, should be carried out with caution, because The development of system adrenergic effects is possible. The vasopressor effect of adrenergic agents can be potentiated by tricyclic antidepressants, propranolol, reserpine, guanethidine, methyldop and M-cholinoblockers. The use of a 10% solution of IRFINIRINA in combination with systemic use of beta-adrenobloclars can lead to acute arterial hypertension. Impirin can potentiate the oppression of cardiovascular activities during inhalation anesthesia.

List B: In the place protected from light, at a temperature not higher than 25 ° C (do not freeze).

S Feeling Organs

S01 Preparations for the treatment of eye diseases

S01F Midryatiki

S01FB sympathomimetics (excluding anti-counterproof drugs)

This article allows you to familiarize yourself with the instructions for the use of the drug. Icifrin. Reviews of site visitors - consumers of this medicine, as well as the views of the doctors of specialists in the use of IMIFIRINA in their practice. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogues of Incentive in the presence of available structural analogues. Use for the treatment of iridocyclite and expanding the pupil in adults, children, as well as during pregnancy and breastfeeding.

Icifrin - sympathomometh. It has pronounced alpha adrenergic activity and when applied in conventional doses does not have a significant stimulating effect on the CNS.

Under the local application in ophthalmology, it causes an expansion of the pupil, improves the outflow of intraocular fluid and narrows the vessels of the conjunctiva.

The phenylephrine (active substance of the drug IRFRINIRI) has a pronounced stimulating effect on postsynaptic alpha-adrenoreceptors, has a very weak effect on myocardial beta-adrenoreceptors. The drug has a vasoconstrictor action similar to the action of norepinephrine (norepinephrine), while it practically lacks chronotropic and inotropic effect on the heart. Phenylefrin's vasopressor effect is weaker than that of norepinephrine, but is longer. Causes vasoconstriction after 30-90 seconds after instillation, the duration of action is 2-6 hours.

After instillation, phenylephrine reduces the pupil dilator and the smooth muscles of the arteriol conjunctiva, thereby causing the expansion of the pupil. Midships occurs within 10-60 minutes after one-time instillation. After the droplets of the eye drops 2.5%, mydriasis is preserved for 2 hours, after injection of drops of the eye 10% - 3-7 hours. Since Phenylephrine has a slight impact on the ciliary muscle, mydriasis occurs without cyclopelia.

Structure

Phenylephrina hydrochloride + excipients.

Indications

iridocyclite (for the prevention of the occurrence of the rear synechs and reduce exudation from the iris);
for diagnostic expansion of the pupil with ophthalmoscopy and other diagnostic procedures necessary to monitor the state of the rear segment of the eye;
conducting a provocative test in patients with a narrow angle of the front chamber of the eye and suspicion of the closedian glaucoma;
differential diagnosis of surface and deep injection of the eyeball;
in ophthalmic surgery - with preoperative preparation for the expansion of the pupil (drops of eye 10%);
to expand the pupil when conducting laser interventions on the eye day and in vitreo-retinal surgery;
treatment of glaucomo-cyclitic crises;
treatment of red eyes syndrome (Eye drops 2.5%) to reduce hyperemia and irritation of eye shells;
accommodation spasm.

Forms of release

Eye drops 2.5% and 10%.

Eye drops 2.5% Intrinine BC.

Instructions for use and method of use

When conducting ophthalmoscopy, eye drops are used 2.5% once in the form of instillations. As a rule, to create a mydriasis, it is sufficiently administered to a conjunctival bag 1 drops. The maximum mydriasis is achieved in 15-30 minutes and is maintained at a sufficient level for 1-3 hours. If it is necessary to maintain mydriasis for a long time after 1 hour, repeated instilization is possible.

In adults and children over 12 years old, with insufficient expansion of the pupil, as well as in patients with a rigid iris (severe pigmentation) for the diagnostic expansion of the pupil, it is possible to use dropper of the eye 10% in the same dose.

To remove the accumulation of accommodation to adults and children older than 6 years old are prescribed drops Eye 2.5% 1 drop in each eye overnight daily for 4 weeks.

In the case of a resistant accommodation spasca, droplets of the eye 10% in adults and children over 12 years old - 1 drop in each eye overnight daily for 2 weeks.

When conducting diagnostic procedures, one-time instillation of the eye drops 2.5% is applied in the following cases:

as a provocative test in patients with a narrow profile of an angle of the anterior chamber and suspicion of an indoor glaucoma - if the difference between the intraocular pressure values \u200b\u200bbefore the injection of the IP and after the increase in the pupil is from 3 to 5 mm Hg, then the provocative test is considered positive;
for differential diagnosis of the type of injection of the eyeball - if after 5 minutes after the instillation, the narrowing of the vessels of the eyeball is noted, the injection is classified as superficial, while maintaining the redness of the eye, it is necessary to carefully examine the patient for the presence of iridocyclitis or sclerite, because This indicates the expansion of deeper vessels.

In case of iridocyclitis, IRFIRIN is used in the form of drops of an eye 2.5% or 10% to prevent the development and rupture of the already formed rear synechs and to reduce the exudation into the front chamber of the eye. To this end, in the conjunctival bag of the patient's eye (eye), I bury 1 drop 2-3 times a day.

In glaucomous-cyclic crises, due to the vasoconstrictor action of phenylephrine, a decrease in intraocular pressure is reduced, this effect is more pronounced when using Irifirodin in the form of drops of the eye 10%. To relieve glaucomo-cyclic crises, the drug is buried 2-3 times a day.

When preparing for surgical interventions 30-60 minutes before the operation, in order to achieve mydriasis, one-time Intilin is produced in the form of dropper drops 10%. After opening the shells of the eyeball, the repeated injection of the drug is not allowed.

Eye drops 10% are not used for irrigation, impregnation of tampons during operational interventions and for subconjunctive administration.

Side effect

conjunctivitis;
periorbital swelling;
sensation of burning at the beginning of use;
blurred vision;
irritation, discomfort feeling;
tear;
an increase in intraocular pressure;
reactive miosis;
feeling of heartbeat;
tachycardia;
arrhythmia (including ventricular);
arterial hypertension;
reflex bradycardia;
occlusion coronary arteries;
embolism of the pulmonary artery;
contact dermatitis;
myocardial infarction;
vascular collapse;
intracranial hemorrhage.

Contraindications

clothing or narrow-edged glaucoma;
elderly patients with serious impairment from the cardiovascular system and brain circulation;
for additional expansion of the pupil during surgical operations in patients with impaired integrity of the eyeball, as well as in disruption of tear-products;
aneurysm Arteries (drops Eye 10%);
hyperthyroidism;
hepatic porphyria;
congenital deficiency of glucose-6-phosphate dehydrogenase;
children's age up to 12 years old (drops Eye 10%);
premature (drops Eye 2.5%);
increased sensitivity to the drug.

Application in pregnancy and breastfeeding

Since the effect of ICFRIN in pregnancy and during lactation, it is not studied enough, the use of the drug in these patients is possible only in cases where the expected benefit of therapy for the mother exceeds the potential risk to the fetus or an inferior child.

special instructions

With caution, it should be used by ICRIRIN in patients with diabetes mellitus due to the risk of developing an increase in Hell, associated with a violation of vegetative regulation, as well as in elderly patients - due to an increase in the risk of reactive mine.

I can use ICRIRIN simultaneously with Mao inhibitors, as well as within 21 days after the cessation of their reception.

The excess of the recommended dose with the use of drops of eye-eye 2.5% in patients with injuries, diseases of the eye or its appendages, in the postoperative period or with reduced tear-product (anesthesia) can lead to an increase in phenylephrine absorption and the development of system side effects.

Due to the fact that the drug causes hypoxia conjunctiva, it is necessary to use in patients with sickle cell anemia in patients with sickle cell anemia, when wearing contact lenses, after surgery (reduction of healing).

Medicinal interaction

The phonilephrine's mymatic effect is enhanced when it is used in combination with atropine. Due to increased vasopressor action, tachycardia is possible.

When using ICRIFINA simultaneously with MAO inhibitors or within 21 days after the cessation of their reception, there is a risk of developing uncontrollable lifting of blood pressure.

Vasopressor action of adrenomimetic drugs can also be potential when sharing with tricyclic antidepressants, propranolol, reserpine, guanethidine, methyldop and m-cholinoblockers.

The use of ICRIFINIZIN in the form of drops of the eye 10% in combination with the systemic use of beta-adrenoblockers can lead to acute arterial hypertension.

ICRIRINA can potentiate an inhibitory effect on the activity of the cardiovascular system during inhalation anesthesia.

Application together with sympathomimetics can enhance the cardiovascular effects of phenylephrine.

Analogs of the Medicinal Izdigin

Structural analogues for the acting substance:

Visofrine;
ICRIRY BK;
Meston;
Nazol Baby;
Nazol KIDS;
Neosinephrin PIT;
Phenylefrin hydrochloride.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, from which the appropriate drug helps and see the existing analogues on therapeutic effects.

I and FRINIRIN - drops related to the group of drugs that provoke emission of norepinephrine, which in turn leads to narrowing vessels and expansion of the pupil. They successfully apply to the treatment of many eye disease, both inflammatory and arising due to an increased visual load.

Eye drops ICRIFIRIN belong to the group of drugs called sympathomimetics. The mechanism of action of these substances is very interesting. They increase the allocation of norepinephrine from nerve endings. Noraderenalin, in turn, is a mediator responsible for waking up the body in the body, with the emission of which the blood narrowing is observed in the blood, the expansion of the pupil.

The main active substance drops - phenylephrine. Due to its vasoconductive properties, it is applied not only in ophthalmology and is part of anti-album and antiallergic drugs. Phenylephrine removes the swelling of the nasopharynx. It is also injected with a sharp decrease in blood pressure and a sharp drop of vascular tone.

With regard to the use of phenylephrine in ophthalmology, in particular as part of the ICP, it is used in two purposes: for treatment and diagnosis.

Cases in which ICF contributes to ophthalmic diagnostics:

preparation K. eye operations (drops are used to expand the pupil);
distinction (differential diagnosis) surface or deep injection of the eyeball;
conducting a test for the presence of a closedian glaucoma in persons having a narrow angle of the front eye chamber;
expansion of the pupil with ophthalmoscopy (eye-catching inspection).

Penylefrin's IC content drops 2.5% or 10% are used in diagnostics and preoperative preparation, based on the following recommendations:

To inspect the eye bottom, the drug is buried in the size of one drop into each eye. Next happens from fifteen to thirty minutes, while the pupil is expanded. The next step will be directly examined. If its duration exceeds one hour, then in the eye is already buried in one drop. In the event that the expansion of the pupil turned out to be insufficient, it is advisable to use IP of 10%.
The test that determines the presence or absence of an closed gloomy involves the use of 2.5% IRFINIRINA. The first step with such a test is measured in the eye, then I am injected with ICFRIN. Then they look at the difference of pressures before expanding the pupil and after. If it is 3-5 mm Hg. Art., the closedian glaucoma is confirmed.
To determine the surface or deep is the injection of the eyeball, I am injected into the eyes 2.5, after a five-minute wait, you can fix the result of the survey. If redness resolved, it means that it is superficial, and if preserved, it means, affects deep layers. Next, there is a further differential diagnosis of eye pathology.
In preparatory preoperative manipulations, only 10% drops are applied. They are brought by one to each eye for half an hour - an hour before surgery.

Eye diseases, in the presence of Irifin:

glaucomocylty crises (optimal 10% solution);
red eyes syndrome (only drops with 2.5% compound of phenylephrine are used);
iridocyclitis;
false myopia.

Glaucomocyclic crisis is a disease that combines a jump-like rise in eye pressure and symptoms of cyclitis: redness, drop view, pain (especially at night), tear.

Red Eyes Syndrome is redness due to extended vessels or blood hemorrhage. It accompanies a whole group of pathologies, allergic, bacterial and viral. The eye doctor due to the nature of pain and other signs differentiates the disease.

Iridocyclitis is an inflammatory disease that affects the iris and the middle vascular shell of the eye. In case of iridocyclite, there are such negative manifestations as swelling, redness and eye pain, the deformation of the pupil, the fall in view.

Accommodation spasm - pathology characterized by a long-term reduction in the muscle responsible for focusing. The second name of this disease is false myopia. False myopia is characteristic of the permanent voltage of the ciliary muscle. This pathology is often found in schoolchildren and is reversible, but over time can go to the myopia true.

With such a disease, as glaucomocyclothic crises, the optimal will be the use of 10% drops, they should be buried on one to each eye two or three times a day.

In case of iridocyclotes, ICRIRIN drops are used to reduce the amount of fluid produced due to inflammatory process. You can use IP drops for both 2.5% and in 10% solution. The drug is drunk one drop into each eye two or three times during the day. The concentration of the active substance in drops is determined by the doctor.

In order to eliminate the false myopia, I amter 2.5% apply. Drops are buried daily by one to each eye. The course is thirty days. If the 2.5% drops do not solve the problem, and spasm is preserved, the doctor prescribes a 10% solution. It must be used fourteen days.

Therapeutic drops Icifillary for children

IN childhood, including preschoolers and children of younger school age, they are appointed for the treatment of myopia and hyperopia. The child, just enrolled in school, to its usual auditorium (TV, Internet), adds cool and extracurricular activities. For visual organs This is a big stress, often the first years of study are accompanied by the fatigue of the eyes and a fall in view. This process can be prevented by incurring the child to make short breaks while watching movies and execution. homework. And in school lessons, the habit of looking into the window to translate with close objects to more remote items will be a useful contribution to eye health.

Intrinarine drops on the background of loads are prescribed by courses. The course of treatment is thirty days, they bury them for the night on one drop in each eye every day, or two drops in every eye every other day. After a course of treatment, the symptoms of fatigue, the eyes cease to hurt, get to get to get drunk and strongly tired. Often, thanks to the use of drops, the process of vision loss is possible to suspend. And in order to prevent wearing glasses and lenses, it is important to instill a child with the right attitude towards the health of the eyes, teach it to listen to your feelings. If fatigue appeared, with the first opportunity it is necessary to take a break, gymnastics or to do something neutral for the eyes - this approach solves the problem of system loads.

What happens after applying Incenter?

Immediately after instillation, the droplets arise a feeling of burning in the eye. After a few seconds, it passes and discomfort ends. After applying the drug, the eyes cannot be loaded for two or three hours: read, write, do the needlework, watch TV or use a computer. After fifteen-twenty minutes, visual functions worsen, visible objects are blurred, and the light blinds the eyes. This state is steadily held for several hours. Iciforin droplets are used before bedtime so that their effects accounted for an inactive phase of the day.

People in the list of diseases of which are listed hypertonic disease, a few minutes after instillation, drops can feel or fix the instruments to increase pressure. This effect quickly passes, so you should not make any measures or begin to worry. People who wear lenses at the time of the course of treatment will have to abandon them and go to glasses. Re-back to the lenses can after three or four-day break. You should also be prepared for the fact that after the course of treatment with the drug, the ICRIFIN vision one to three days will be blurred and not quite clear. However, visual functions are improving, and the eyes begin to see better than before the treatment.

By regularly using IF, you can see that pain leaves, the eyes are less tired in the evening. If the vision is not too much from a healthy norm, the ICFRIN drops can improve it so that the glasses do not have to wear anymore. Healthy habits concerning eye hygiene, labor and recreation, walks, exercises, thanks to which organs of vision are provided by the necessary amount of blood and oxygen, help support and consolidate the positive effect of the drug.

The release form of the drug IAFRIN

I and FRINIRIN - drops that are produced in 5 ml bottles. After opening, they can be used for a month.

Drops should be bought from these recommendations:

raise your head up;
till the lower eyelid;
holding the bottle at a distance of 2 cm, squeeze the solution to each eye;
during the instillation, make sure that the tip of the bottle does not touch the mucous;
when the drop falls on the mucous membrane, hold the inner angle of the eye, so as not to work the reflex and the drug managed to absorb;
do not forget about the need to exclude visual loads after IP application.

Application of droplets during pregnancy and breastfeeding

special instructions

When instilcing Irifirin more than two drops in each eye, an enhanced absorption of the drug in blood can occur, which will lead to by-effects. The risk is especially great during the recovery period after the eye injuries or at a low level of tear fluid. When using the drug, it is recommended to abide by diabetics and people over sixty-five years old. Sugar diabetes can provoke an increase in blood pressure, and in old age there is a chance of a sharp narrowing of pupil instead of the necessary expansion.

So, the active substance drops of ICFRIRIN accelerates the process of outflow of intraocular fluid, narrows blood vessels. Due to their narrowing, there is no red eye syndrome, and the reinforced outflow of intraocular fluid improves the condition of patients with glaucoma. ICRIRIN - drops that promote the expansion of the pupil, this effect is used in diagnostic procedures, as well as in preoperative preparation.