Some facts about the product:

Instructions for use

Price in the Internet pharmacy Site: from 35

Pharmacological properties

Drug bispetol is medical meanshaving a directional bactericidal and bacteriostatic action. The active components of the medicine are TrimeThoprim and Sulfamethoxazole. Sulfamethoxazole has a similar structure with para-aminobenzoic acid. Its action is directed to the obstacle to the processes of synthesizing dihydrofolate-reductase in infected cells, which limits the ingress of para-aminobenzoic acid into the molecules of these cells. Timetroprime suspends the transformation of dihydrofolate-reductase into tetrahydrofolate, which does not allow the infected cell to share. Also one of the qualities of trimethopris is an increase pharmacological action Sulfamethoxazole substances.

The greatest activity of the drug shows in relation to such bacteria like Pneumococcus, Staphylococcus, monocytogenesis, Bacillus, Nocardia Asteroides, Mycobacteria, Enterococcus Fecal, Meningokok, Intestinal wand, Gonococcus, Salmonella, Cholera Vibrion, Chlebseyella, Hemophilic wand, Pastell Multocide, Cocktle Wand, Citrobacter Freudi, Protea Mirabilis, Brucellia, Providence, Enterobacter, Legionella Pneumophil, Pseudomonada, Schigella Flexner, Sergey Marseszenza, Pseudotuberculose Child, Chlamydia, Bacteria Morgan, Toxoplasm, Cocidioidosis Immitis, Plasmodium, Pneumatic Pneumonia, Leinsmania.

Constant when interacting with Biseptol remain bacteria such as Corinbacteria, koch wand, a cinema wand, leptospirosis, pale treponema.

The drug has almost one hundred percent bioavailability, absorbed from digestive system. Its maximum blood content is reached within four hours from the moment of use. A medication is distributed in tissues and organs about the same ratio. Elimination is carried out by the kidneys unchanged.

Composition and form of release

The release of the drug-based bispetol is carried out in the form of tablets and suspension.

For the production of tablets, the following components are used:

• auxiliary substances in the form of potato starch, polyvinyl alcohol, preservative E128, para-hydroxybenzoic acid propyl ether, Propane-1,2-Diol.

Tablets have a round shape without convexities. Tablets color varies from pure white to white with yellowish shades. On each side of the diameter, chamfer and abbreviation is applied, denoting the name of the drug. Their primary packaging is polyvinyl chloride blister packs, in which twenty tablets are placed. One blister plate along with the instructions for use is packaged in a cardboard pack.

For the production of suspension, the following components are used:

• tRIMETHOPRIM and SULFAMETHOXAZOLE Activities;
• auxiliary substances in the form of citric acid monohydrate, methyl aprohydroxybenzoate, saccharine, sweetener of Malthitol E965, strawberry aldehyde, purified water, Propane-1,2-Diol, Carmellose Sodium, Macrogol Glyceryl HydroxyStearate, Magnesium Aluminum Silicate, Sodium Orthophosphate Dodecahydrate.

The suspension has a homogeneous consistency with the characteristic aroma of strawberries. Color varies from pure white to white with creamy shades. Its primary packaging is a dark glass bottle with a screwed lid. The bottle along with the instruction is located in a cardboard pack.

Indications for use

The prescription of the drug Biseptol is carried out for the treatment of the following diseases:

• bronchitis in the aggravation stage;
• pneumonia;
• inflammation of the middle ear;
• inflammation of lymph nodes and ulcers in the genitals;
• infectious diseases of the genitourinary system;
• intestinal disease caused by bacteria salmonella;
• dysentery;
• frequent liquid stool caused by an intestinal wand;
• disorders of the digestive tract;
• other diseases caused by infectious microbacteriums.

Side effects

Side effects after using the drug may occur from various organism systems. These include:

• spasmodation of muscles of bronchi;
• feeling of the scene, turning into vomiting;
• cough, difficulty breathing;
• frequent liquid chair;
• dizziness, migraine;
• weakness, decay of forces;
• depressive condition;
• convulsions of the limbs;
• change of appetite;
• inflammation of the pancreas;
• pain in the abdomen;
• inflammation of the mucous membrane;
• cholestatic syndrome;
• increase in the activity of liver enzymes;
• liver inflammation;
• liver disease in chronic form;
• inflammation of the intestines;
• inflammation of the gastric mucosa;
• lowering the level of leukocytes, platelets, neutrophils;
• anemia;
• blood coagulation disorders;
• raising the level of methemoglobin in the blood;
• an increase in urine production;
• kidney inflammation;
• increased blood content in the urine above the physiological norm;
• pain in the joints;
• muscle pain;
• photosensitivity;
• allergic reactions in the form of itching, burning, dermatitis;
• swelling of subcutaneous fiber;
• lowering blood sugar;
• increasing blood potassium content.

Contraindications

The bispetol drug should not be used in the presence of one of the following contraindications:

• hypersensitivity to individual components present in the composition of the medication;
• diseases of the kidneys in severe form;
• blood disease in severe form;
• damage to hepatic tissue;
• raising bilirubin level in childhood;
• robeson's ether deficiency.

Pregnancy and lactation

Biseptol in tablets to take during pregnancy is prohibited. Suspension should be prescribed with caution in cases where the estimated benefit for the mother is higher than the potential threat to the embryo.

It is clinically established that the effective component of the drug is highlighted with breast milk. In this regard, it is recommended to suspend breastfeeding for the period of use of the medication.

Application: Method and Features

The bispetol drug is administered orally. Therapy scheme, as well as the dosage varies depending on the age of the patient.

Tablets are assigned:

• adults and children older than twelve years in two tablets dosage of four hundred eighty milligrams in the morning and in the evening;
• children from six years to twelve one tablet dosage of four hundred eighty milligrams in the morning and in the evening;
• children from three to six years old two tablets dosage two hundred forty milligrams in the morning and in the evening.

The average duration of the therapeutic course of pills is from one to two weeks.

Suspension is appointed:

• adults and children older than twelve four-dimensional spoons in the morning and in the evening;
• children from six years to twelve two dimensional spoons in the morning and in the evening;
• children from three to six years old one or two dimensional spoons in the morning and in the evening.
• children from six months to three years on one dimensional spoon in the morning and in the evening.
• children from three months to six months at half a dimensional spoon in the morning and in the evening.

The average duration of the therapeutic course of the suspension is from ten days to two weeks.

Compatible with alcohol

It is not recommended to use alcohol-containing drinks during the therapeutic course. Alcohol can reduce pharmacological properties drug. In some cases, disorders are possible in the work of various organism systems.

Interaction with other medicines

When using the bispetol preparation with diuretics, a drop of platelet levels may be reduced.

With simultaneous use with anticoagulants it is possible to reduce blood coagulation.

Drug tools that contribute to the formation of para-aminobenzoic acid, reduce the effectiveness of the existing components of bispetol.

When using tricyclic antidepressants, it is possible to reduce their effectiveness.

Overdose

With overdose arise the following symptoms:

• change of appetite;
• feeling of nausea with vomit;
• dizziness, migraine;
• powerlessness, decay of forces;
• temperature increase;
• raising blood levels in the urine;
• fainting;
• depressive condition;
• violation of the concentration of attention.

To eliminate these symptoms, it is necessary to immediately stop the reception of the medication, washing the stomach with the aim of the speedy removal of the drug residues from the body. The frequent absorption of fluid and competent supporting therapy is recommended.

special instructions

Side effects most often occurred in patients having acquired immunodeficiency syndrome.

It does not affect the management of vehicles, as well as to engage in activities that require increased attention.

Analogs

The drug has the following analog agents similar to the spectrum: baktisptol, babit, bundime, b-sept-pharmac, origamm, solespetol, sowepolim, trispensol.

International Classification of Diseases (ICD-10)

According to international Classification Diseases (ICD-10) The diagnoses under which this medication is used to have the following encoding:

• abdominal title (A01.0);
• brucellosis (A23.9);
• cocktle (A37);
• scarlatina (A38);
• pneumocytosis (B59);
• outdoor otitis (h60);
• acute sinusitis (j01);
• acute laryngitis (J04.0);
• acute bronchitis (J20).

Terms of sale

In pharmacy points, Biseptol is implemented in accordance with the prescriptions of the attending physician.

Storage rules, shelf life

According to the instructions, the drug should be stored in a closed place at a temperature of less than twenty-five degrees Celsius not more than three years.

**** POLFA (PABYANTIC PHARMZAVOD) POLFA (Pabyanitsky Pharmaceutical) / OJSC Accreamer TERPOL + Akrichin Terpol + Synthesis Akrichin KhFK JSC MEDA Pharma Joint Stock Company MEDA Farma Terrp Group Joint Stock Company Pabyanitsky Pharmaceutical Plant Pabyanitsky Pharmaceutical Plant Pabyanitsky Pharmaceutical Pharmaceutical / CJSC "Ortat" Polafa, Warsaw Pharmaceutical Plant Pharmaceutical Pharmaceutical Plant AO Pafeharma, Pharmaceutical Plant, JSC / Akrichin HFK

Country of origin

Poland Russia

Group of goods

Antibacterial drugs

Antibacterial sulfanimide drug

Forms of release

• 20 - Blisters (1) - Puttings Cardboard 20 - Blisters (1) - Cardboard packs. 20 pcs. - Blister (1) - packs cardboard. 80 ml - dark glass vials (1) - packs cardboard pack 10ampules 5ml

Description of the dosage form

• Concentrate for the preparation of the solution for infusion suspension oral white or light cream color, with strawberry smell. White tablets with a yellowish color shade, round, flat, with chamfer and engraving "BS". White tablets with a yellowish color shade, round, flat, with chamfer and engraving "BS". White tablets with a yellowish color tinge, round, flat, with chamfer, risk and engraving "BS". White tablets with a yellowish color tinge, round, flat, with chamfer, risk and engraving "BS".

pharmachologic effect

Combined antibacterial drug, Contains sulfamethoxazole and trimethopris. Sulfamethoxazole, similar in structure with PABK, violates Synthesis Dihydro folic acid In bacterial cells, preventing the inclusion of PABK in its molecule. Trimethoprium enhances the effect of sulfamethoxazole, disrupting the reduction of dihydrofoliic acid into the tetrahydrofolya - the active form of folic acid responsible for protein metabolism and division of the microbial cell. It is a bactericidal preparation of a wide range of action. Active with respect to gram-positive aerobic bacteria: Streptococcus SPP., Including Streptococcus Pneumoniae (hemolytic strains are more sensitive to penicillin), Staphylococcus SPP., Bacillus Anthracis, Listeria Monocytogenes, Nocardia Asteroides, Enterococcus Faecalis, Mycobacterium SPP. (including Mycobacterium Leprae, excluding mycobacterium tuberculosis); Gram-negative aerobic bacteria: Neisseria Meningitidis, Neisseria Gonorrhoeae, Escherichia Coli (including enterotoxogenic strains), Salmonella SPP. (including Salmonella Typhi and Salmonella Paratyphi); Vibrio Cholerae, Haemophilus influenzae. (Including the ampicillin resistance strains), Bordetella pertussis, Klebsiella spp., Proteus spp., Pasteurella spp., Francisella tularensis, Brucella spp., Citrobacter spp., Enterobacter spp., Legionella pneumopbila, Providencia, some species Pseudomonas (except Pseudomonas aeruginosa), Serratia Marcescens, Shigella SPP., Yersinia SPP., Morganella SPP., As well as with regard to Chlamydia SPP. (including chlamydia trachomatis, chlamydia psittaci); Regarding gram-positive anaerobov: Actinomyces Israelii; Regarding the simplest: Plasmodium SPP., TOXOPLASMA GONDII; Pathogenic fungi: Coccidioides Immitis, Histoplasma Capsulatum, Pneumocystis Carinii, Leishmania SPP. To the drug is stable: Corynebacterium SPP., Pseudomonas Aeruginosa, Mycobacterium Tuberculosis, Treponema SPP., Leptospira SPP., Viruses. Inhibits the life activity of the intestinal stick, which leads to a decrease in the synthesis of thiamine, riboflavin, nicotine acid and other vitamins of the group in the intestine. The duration of the therapeutic action is 7 hours.

Pharmacokinetics

The drug quickly penetrates the tissue and biological fluids of the body. Well distributed. Penetrates the BC, a placental barrier and breast milk. In the lungs and urine creates concentrations exceeding the content in the plasma. Less extent accumulate in the bronchial secretion, vaginal discharge, secrete and tissues prostatic gland, medium ear liquids, spindomy fluid, bile, bones, saliva, water moisture, breast milk, interstitial fluid. The distribution of both drugs is Miscellaneous: sulfamethoxazole is distributed exclusively in the extracellular space, and trimethopris - both inside cells and in the extracellular space. Binding with plasma proteins is 66% in sulfamethoxazole, Trimethopris - 45%. Both drugs are metabolized in the liver. A sulfamethoxazole (with the formation of acetylated derivatives) is metabolized, metabolites do not have antimicrobial activity. Are removed by the kidneys, both by filtration and by actively secretion by tubules, in the form of metabolites (80% for 72 hours) and unchanged (20% sulfamethoxazole, 50% trimethopris), the concentration of active substances in the urine is significantly higher than in blood . An insignificant amount of drug is excreted through the intestines. T1 / 2 sulfamethoxazole - 9-11 hours, trimethopris - 10-12h, in children - significantly less and depends on the age: until the first year - 7-8h, 1-10 years - 5-6 hours. In the elderly and patients with violation Kidney functions T1 / 2 increases.

Special conditions

Caution prescribed the drug with a burdened allergological history. With a long (more than a month) treatment courses, regular blood tests are needed, since there is a likelihood of hematological changes (most often asymptomatic). These changes can be reversible when prescribing folic acid (3-6 mg / day), which does not significantly violate the antimicrobial activity of the drug. Special caution is necessary in the treatment of elderly patients or patients with suspicion of the original lack of folates. The purpose of folic acid is also suitable with long-term treatment with a drug in high doses. For the prevention of crystaluria, it is recommended to maintain the sufficient amount of urine allocated. The probability of toxic and allergic complications of sulfanimamides increases significantly by reducing the filtering function of the kidneys. It is also impractical on the background of treating food products containing a large number of PABK, green parts of plants (cauliflower, spinach, legumes), carrots, tomatoes. Excessive solar and UV irradiation should be avoided. Risk side Effects significantly higher in patients AIDS. It is not recommended to use the drug in tonsillitis and pharyngitis caused by? -Gemolytic streptococcus Group A, due to widespread resistance of strains. Timetoprix can change the results of determining the level of methotrexate in serum conducted by the enzymatic method, but does not affect the result when choosing a radioimmunological method. Co-trimoxazole can rise by 10% the results of the jaffe reaction with picric acid for quantitative determination of creatinine. Overdose symptoms: no appetite, intestinal colic, nausea, vomiting, dizziness, headache, drowsiness, loss of consciousness, also fever, hematuria, crystalluria are also possible. Later, the oppression of bone marrow and jaundice can develop. After acute poisoning, trimethoprim is possible nausea, vomiting, dizziness, headache, depression, disorder of consciousness, inhibition of bone marrow function. It is not known what kind of co-trimoxazole dose can be dangerous for life. Chronic poisoning: The use of co-trimoxazole in high doses over a long period may result in the oppression of the bone marrow function, manifested by thrombocytopenia, leukopenia or megaloblastic anemia. Treatment: Cancellation and adoption of measures aimed at removing from the gastrointestinal removal (to carry out the stomach no later than 2 hours after taking the drug or cause vomiting), abundant drink if diuresis is insufficient, and the kidney function is saved. Enter calcium folinate (5-10 mg / day). The acidic urine environment speeds up the removal of trimethopril, but can also increase the risk of crystallization of sulfonamide in the kidneys. The picture is controlled, the composition of the electrolytes in plasma and other biochemical parameters. Hemodialysis is moderately effective, and peritoneal dialysis is not effective.

Structure

• 1 tab. Sulfamethoxazole 400 mg Timetoprix 80 mg Auxiliary substances: Potato starch, talc, magnesium stearate, alcohol polyvinyl, methyl apotrohydroxybenzoate, propylene glycol. Sulfamethoxazole 200 mg Trimethopris 40 mg Ancientities: Cremorphor Rh 40, magnesium aluminum silicate, sodium carboxymethylcellulose, monohydrate monohydrate, sodium hydrophosphate, methyl hydroxybenzoate, propyl hydrocybenzoate, sodium saccharinate, maltitol, strawberry fragrance, propylene glycol, water purified. Does not contain sugar. Sulfamethoxazole100 mg Trimethoprim20 mg Auxiliary substances: Potato starch, talc, magnesium stearate, alcohol polyvinyl, methylpaultydroxybenzoate, propyl apicultural glycol. Sulfamethoxazole400 mg Trimethoprim80 mg Auxiliary substances: Potato starch, Talc, Magnesium Stearath, Alcohol Polyvinyl, methyl apkhydroxybenzoate, propylene, propylene glycol

Biseptol Indications for use

• - acute and chronic urinary infections: urethritis, pyelonephritis, cystitis, pyelitis, prostatitis, epidididitis, gonorrhea, soft chance, venereal lymphogranulham, granuloma; - Infections Respiratoryways: bronchitis (acute and chronic) bronchiectatic disease, bodyproof pneumonia, bronchopneumonium, pneumatic pneumonia, empty pleura, lung abscess; - ENT-organ infections: medium otitis, sinusitis, laryngitis, angina, scarlet; - PCT infections: abdominal typhoid, paratif, salmoneselosis, cholera, dysentery, cholecystitis, cholangitis, gastroenteritis, caused by E. coli enterotoxic strains; - Skin and soft tissue infections: acne, furunculosis, pyodermia, abscess and wound infections, infections after surgical interventions; - sepsis, acute brucellosis, toxoplasmosis, osteomyelitis, osteoarticular infections, South American blastomycosis, Malaria (Plasmodium Falciparum), Cocal (as part of complex therapy).

Biseptol Contraindication

• - Mounted damage to the liver parenchyma; - pronounced disorders of the kidney function in the absence of the possibility of controlling the concentration of the drug in blood plasma; - renal failure of severe (QC less than 15 ml / min); - severe blood diseases (aplastic anemia, B12 deficient anemia, agranulocytosis, leukopenia, megaloblastic anemia, anemia associated with folic acid deficiency); - hyperbilirubinemia in children; - deficiency of glucose-6-phosphate dehydrogenase (risk of hemolysis); - pregnancy; - lactation; - children's age up to 3 years (for this dosage form); - increased sensitivity to the components of the drug; - Increased sensitivity to sulfanimamides. Caution prescribed the drug with a deficiency of folic acid in the body, bronchial asthma, diseases thyroid gland.

Biseptol Dosage

• 120 mg 480 mg 96 mg / ml

Biseptol Side effects

• From the CNS and peripheral nervous system: Headache, dizziness; In some cases - aseptic meningitis, depression, apathy, tremor, peripheral neurites. By the respiratory system: bronchospasm, suffocation, cough, pulmonary infiltrates. From the digestive system: nausea, vomiting, decline in appetite, diarrhea, gastritis, abdominal pain, glossitis, stomatitis, cholestasis, increased activity of hepatic transaminases, hepatitis, sometimes with cholestatic jaundice, hepatonecosis, pseudommbranous enterocolitis, pancreatitis. From the hematoporation system: leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia, aplastic and hemolytic anemia, Eosinophilia, Hypoprothrombinemia, methemoglobinemia. From the urinary system: polyuria, interstitial nephritis, impairment of kidney function, crystalluria, hematuria, increased urea concentration, hypercreaticinemia, toxic nephropathy with Oligira and Anuria. From side bone-muscular system: Arthralgia, Malgy. Allergic reactions: itching, photosensibilization, urticaria, medicinal fever, rash, multiform exudative erythema (including Stevens-Johnson syndrome), toxic epidermal necrolis (Layella syndrome), exfoliative dermatitis, allergic myocarditis, body temperature increase, angioedema edema, Schler hyperemia. From the metabolism: hypoglycemia, hypercalemia, hyponatremia. The drug is usually well tolerated.

Medicinal interaction

Biseptol enhances the effect of phenytoin, oral hypoglycemic agents, derivatives of warfarin (prothnce of prothrombin time, bleeding). In senior patients in combination with diuretics (in particular, with thiazide diuretics), the risk of thrombocytopenia increases. Simultaneous use with cyclosporin reduces its concentration in the blood. Do not enter the drug intravenously in combination with medicinal preparations and solutions containing bicarbonates. Biseptol is pharmaceutically compatible with next drugs: dextrose for in / in infusion infusion 5%, sodium chloride for in / in infusions 0.9%, mixture 0.18% sodium chloride and 4% dextrose for infusion, 6% dextran 70 for in / in infusion in 5% dextrose or in infusion Physiological solution, 10% dextran 40 for in / in infusion in 5% dextrose or physiological solution, Ringer's solution for injection.

Overdose

lack of appetite, intestinal colic, nausea, vomiting, dizziness, headache, drowsiness, loss of consciousness, and fever, hematuria, crystalluria are also possible. Later, the oppression of bone marrow and jaundice can develop. After acute poisoning, trimethoprim is possible nausea, vomiting

Storage conditions

• bear from children
• storing

Information is provided by the state register of medicines.

Synonyms

• Ko-trimoxazole, Bactrim, Grosptol, Septrine, Cyplin, etc.

Biseptol is already known for no first decades. In Soviet times, it was the most popular drug almost from any infectious disease, it is both an adult and children's, the price is not high, and the drug is effective. Gradually, he was supplanted with new medications with a large spectrum of action and efficiency. But today, Biseptol does not lose its relevance, and the reviews of doctors confirm this.

Composition and principle of operation

When is Biseptol applied and how much to drink it? As part of one tablet "Biseptol" 120 mg contain 100 mg of sulfamethoxazole, 20 mg of trimethopris and additional components. Accordingly, the dose of 240 mg or 480 mg contains two and three times more active substances. The combined effect of the components of the drug is directed to the oppression of the process of formation of folic acid in the cell of the bacterium. Substances are selected in such a way that they enhance each other's action. This adds efficiency to the drug.

Its action is as follows:

• sulfamethoxazole. - has a structure similar to para-aminobenzoic acid, due to which it interferes with the process of formation of folic acid;
• timetoprim - slows down the transaction of vitamin B9 predecessors to the active form.

Due to this, minimal folic acid concentrations are created, which is extremely necessary for the growth and development of bacteria. "Biseptol" in high concentration causes the death of pathogens sensitive to it and thus eliminates infection.

The activity of the drug applies to the following microorganisms:

• intestinal wand;
• streptococci;
• staphylococci;
• pneumococci;
• bacteria of abdominal and dysentery;
• gonococci;
• salmonella;
• hemophilic stick;
• klebsiella;
• enterococcus;
• chlamydia;
• toxoplasm;
• leishmania.

The remedy does not affect the blue and tuberculous wand, leptospiru, spirochetes and viruses.

When to use

Modern doctors "Biseptol" are prescribed in pathologies caused by pathogenic microbes that are susceptible to the effects of sulfamethoxazole. The method of reconciliation is indicated in the table.

Organs or system of organs	Pathology
Upper respiratory tract	- chronic and acute bronchitis; - inflammatory defeat of the pleura; - pneumonia; - abscesses; - inflammatory complications of bronchiectatic disease; - Larygit
ENT organs	- otitis; - sinusitis (for example, sinusitis, front); - inflammation of almonds (tonsillitis); - Infectious process in slurry and pharynx mucosa
Urinary organs	- inflammation of the appendages of the uterus; - prostatitis; - urethritis; - cystitis; - epididiment; - chronic pyelonephritis; - Gonorrhea
Digestion system	- diarrhea of \u200b\u200bbacterial etiology, including food poisoning; - Inflammation of bile ducts
Leather	- acne; - purulent lesions hair follicles and soft fabrics
Heavy infectious inflammatory diseases with high temperatures	- meningitis; - sepsis; - purulent bone marrow lesions; - severe infections after injuries

Biseptol is effective in toxoplasmosis, malaria. Children "Biseptol" is prescribed in the case of contraindications to antibiotics or an allergic reaction to commonly used means. High efficiency Treatment is achieved with an angina, cough with bronchitis, as well as during a hymorite, inflammation of the lungs, middle ear, intestinal infections, furunculese, increasing lymph nodes. It should be applied only by appointing a doctor.

Contraindications

After receiving the "Biseptol" quickly penetrates the systemic bloodstream and after three to five hours it reaches its maximum concentrations. Metabolized in the liver. High concentrations The drug is created in the kidneys, as it is mainly excreted in the urine. Contraindications for receiving the following:

• hypersensitivity to the components of the drug;
• complex forms of heart failure;
• liver pathology with damage or death of its cells;
• renal failure;
• anemia caused by a lack of folic acid;
• pathology of blood and bone marrow;
• bronchial asthma;
• pollnosis;
• atopic (allergic) dermatitis.

"Biseptol" cannot be taken if the patient in the past had an immunological decrease in platelet levels caused by the drug intake.

The components of the drug contribute to a decrease in the content of folic acid and can lead to its deficiency. In addition, the use of a medicine in the third trimester of the nose can contribute to the emergence of nuclear jaundice in the fetus. Therefore, "Biseptol" during pregnancy and during breastfeeding It is categorically contraindicated for receiving, and also cannot be used to use it for up to three months.

In cases of use of "Biseptol", pregnant women need an additional reception of 5 g of folic acid daily. Elderly people should take this drug with great care. The same applies to patients with thyroid pathologies.

Instructions for use "Biseptol"

Dosage "Biseptol" and the duration of application is appointed by a doctor individually in each case. You can take a convenient form, the method of reception does not differ in the amount of active substance.

Biseptol is produced in tablets of 120 (for children) and 480 mg, in the form of a syrup and suspension in ampoules for receiving inside. Schemes use various shapes Drugs are described in tables.

Table - how to take "Biseptol" depending on age

Tablets or suspension must be taken after eating, picking up with clean non-carbonated water. The reception rate lasts up to 14 days. If therapy lasts more than five days, it is recommended to monitor blood performance. With anomalous oscillations, up to 10 mg of folic acid per day is additionally prescribed.

Depending on the variety and severity of the infectious process, the standard dosage "Biseptol" may vary, which is seen from the table.

Table - Separate Bispetol Reception Schemes

With severe forms of the infectious inflammatory process, the doctor can increase the dose of twice.

Side effects and overdose

The instructions indicate good tolerability of the drug and the minimum risk of side effects. But still you can select the following:

• nausea, vomiting and diarrhea;
• headache, dizziness;
• tendency to depression;
• inflammation of peripheral nerves;
• bronchial spasms, attacks of choking and cough;
• muffed bile outflow;
• acute inflammation of the colon;
• reducing neutrophil levels (agranulocytosis);
• reducing the number of leukocytes and blood platelets;
• deficiency of vitamin B12 and folic acid;
• heavy form of allergic dermatitis;
• the appearance of blood in the urine, crystalluria.

People with HIV infection have the likelihood of side action above.

In case of overdose, the drug is aggravated by headache, nausea, vomiting, abdominal pain, red blood indicators change. Treatment - symptomatic, includes washing the stomach and, if necessary, the introduction of drugs to restore the level of folic acid. For example, based on calcium folinate.

special instructions

When taking "Biseptola" there is a risk of salts crystals in the urine and the formation of kidney stones, therefore, for the prevention of such side effects throughout the treatment, it is necessary to use a sufficient amount of fluid and monitor analyzes.

The simultaneous use of the drug with diuretic means increases the risk of hypokalemia (reduction in blood potassium) and bleeding. For the period of treatment, it is recommended to completely abandon alcohol, so as not to provoke toxic hepatitis. With prolonged therapy, it is necessary to pass tests to track the functional state of the kidneys, liver and control the hematological indicators.

Analogs

Analogues according to the current components are the following drugs:

• "Bactrim";
• "Septrine";
• "SMETROLIM";
• "Berlocide";
• "Challenge";
• "Ko-Trimoxazole."

Receiving funds that have a strong antibacterial effect allows to eliminate diseases whose pathogens are pathogenic fungi, the simplest organisms, gram-positive and gram-negative bacteria. Biseptol tablets - a drug with a bactericidal action: it provokes the death of a microbial cell due to the blocking of folic acid synthesis, without which it loses the ability to divide. This drug does not apply to the antibiotics group. Biseptol is produced in the form of tablets, syrup and suspension. The two recently mentioned forms are usually recommended for the treatment of children. Each dosage form It has features of the reception and dosage, so before the start of treatment it is necessary to obtain an exhaustive consultation of a specialist. Attention should be paid: the medication is released by the prescription.

Biseptol - a preparation with an extensive range of action belongs to the group of bactericides. It is prescribed to eliminate microbes that generate infectious diseases

Characteristic of the drug

Biseptol tablets - combined drugwhich is characterized wide spectrum actions. It contains sulfamethoxazole, which disrupts the synthesis necessary for the development of acid bacteria, as well as trimethoprim - a substance that enhances the effect of the first active component and prevents the reproduction of pathogenic microorganisms.

Biseptol is effective in many pathologies, the effect is manifested soon - on the second day of treatment there is an improvement in the state

This medicine is active in relation to such pathogens as:

• gonococci;
• meningococci;
• chlamydia;
• salmonella;
• intestinal wand;
• some kinds of fungi.

Note! Biseptol does not act on viruses, so it is not used in order to treat viral diseases. The drug is also not active with respect to pathogens and leptospirosis, a cinema stick, spirochete.

This medication is produced not only in the form of tablets - bispetol suspension, syrup and ampoules containing concentrate are also available. Biseptol Suspension is suitable for children; The drug contained in ampoules is used exclusively during inpatient treatment under the control of medical personnel.

Tablets and other forms of the medicine are quickly absorbed from the stomach, and their active ingredients have the ability to penetrate the tissue and biological fluids of the organism - in the kidneys, almonds, light, bronchial secret, cerebrospinal fluid.

Maximum concentration active ingredients The drug in the blood is observed 60 minutes after its admission.

Indications and contraindications for reception of the drug

Biseptol treatment effectively in the treatment of sharp infectious diseases respiratory tract, ENT infections and gastrointestinal tract, disease urinary tract and reproductive system bodies. Also, the use of the drug is advisable in skin infections and soft tissues.

Biseptol is prescribed with infectious inflammatory diseases of the blade and sexual system

The following diseases and pathology are indications of the reception of Biseptol:

• acute and chronic;
• abscess lung;
• malaria;
• scarlet fever;
• brucellosis;
• toxoplasmosis;
• acne;
• brain abscess;
• pyodermia;
• salmonellosis;
• typhoid fever;
• osteomyelitis;
• cholera.

Even with the idea of \u200b\u200bwhich Biseptol helps, should not take it without the appointment of a doctor. This preparation has some absolute contraindications. These include:

• children's age up to 3 months (for suspension) or 3 years (for taking tablets);
• disorders of kidney functions;
• increased sensitivity to the active ingredients of the medication;
• period of tooling the fetus and breastfeeding;
• blood breeding;
• folic acid deficiency in the body;
• liver failure;
• cardiovascular failure.

Note! If the patient had an allergic response to the reception of individual drugs, Biseptol is prescribed with caution, and treatment is in this case under the special control of the doctor. Also, tablets are prescribed in case of diseases of the thyroid gland, in early and old age.

When the patient is recommended to drink bispetol, it is necessarily warned about the likelihood of occurrence. adverse Reactions. Although in most cases this drug is carried by patients well, the following undesirable manifestations may occur:

With long-term reception of high dosages of bispetol side effects May be more pronounced. Occasionally, serious allergic reactions are recorded, due to the change in the composition of the intestinal microflora

• nausea;
• abdominal pain;
• apathy;
• depression;
• dizziness;
• trembling fingers;
• increased urine released;
• sense of lack of air;
• pain in the muscles and joints;
• temperature increase;
• chills;
• skin itch.

Biseptol is contraindicated in patients with severe diseases internal organs - liver, kidneys, as well as blood breeding

SideflinesIn the event of their occurrence, they have weak severity.

Note! Special caution in the treatment of Biseptol must be observed to the elderly, as well as persons suffering from alcoholism or impaired suction of substances.

Biseptol tablets are released in a dosage of 120 and 480 mg. The difference between them is that the first type of drug contains sulfamethoxazole in the amount of 100 mg and trimethopris in the amount of 20 mg; In the preparation with a dosage of 480 mg - 400 mg and 80 mg of substances, respectively.

Each package contains 20 tablets.

Instructions for Tablets Biseptol prescribes the following:

• reception is carried out after meals;
• to prevent the formation of crystals in the urine provoking urolithiasis, it is necessary to drink tablets with plenty of water, and throughout the course of treatment drinks at least 2 liters of water in pure form daily;
• during therapy, restrict the stay under direct ultraviolet rays;
• when taking tablets, adults and children should limit the consumption of protein food, which reduces the efficiency of the drug;
• it is important to refuse to eat alcoholic beverageswhich not only neutralize the effectiveness of the medication, but also may cause the development of allergic reactions.

Before starting treatment, the specialist should explain to the patient how to take Biseptol. The dosage of the drug depends on the existing disease:

• Biseptol with cystitis, other diseases of the urinary tract of infectious nature, as well as chronic in adults are taken according to the following scheme: 960 mg of the drug per day, which is 2 tablets in the dosage of 480 mg or 8 tablets in a dosage of 120 mg. Take tablets you need 2 times a day. Biseptol is taken in the same way;
• the gonor show the reception of 1920-2880 mg of the drug per day. The specified dosage is divided into 3 receptions per day;
• in diarrhea, it is recommended to take 960 mg of the drug, in two receptions. There should be 12 hours between each of them.

The minimum use of the specified medication is 4 days. It is not recommended to continue therapy for more than 2 weeks, since the long-term use of bispetol provokes a violation of folic acid synthesis, and this, in turn, can lead to - bleeding disorders.

In the treatment, it is important not to exceed the prescribed norm of the drug. Overdose Biseptol can cause the following symptoms:

The overdose of bispetol can strongly affect general state patient. This is manifested by frequent headache and dizziness. In some cases - aseptic and depression. With such symptoms it is necessary to consult a doctor

• drowsiness;
• nausea and vomiting;
• fever;
• pre-corrupt state;
• blood appearance in the urine;
• jaundice;
• depression;
• blood breeding.

In the appearance of signs of overdose, the patient has assistance in the form of washing the stomach, intramuscular introduction of folinate, urine acidification.

Is it possible to take pills Biseptol to children?

Is it possible to use Biseptol in childhood? If necessary, the admission of the specified drug, Biseptol for children is recommended in the form of a suspension. It can be given to a child aged 3 months. Biseptol syrup is recommended to give aged 1 year. As for the medication in tablets, it can be used, starting from 3 years. Parents often worries the question whether Biseptol is an antibiotic or not. This means does not apply to a group of such drugs, but its application must be discussed with the doctor.

How many milligrams should be the dose of the drug? Instructions for use of bispetol for children involves the following:

• aged 3 to 5 years daily dose Tablets will be 240 mg (2 tablets with a dosage of 120 mg);
• children from 6 to 12 years old are given 480 mg of the drug per day (4 tablets of 120 mg or 1 in the dosage of 480 mg);
• aged 12 years and older, permissible daily dose can reach 960 mg per day. Daily reception is divided by 2 times.

When taking Biseptol, child parents are important to control his condition. When adverse reactions appear, you must immediately contact a specialist. On the advice of the doctor, you can supplement treatment with vitamin and biologically active additives that soften bad influence The drug to work intestines and kidneys.

Preparations-analogs

Analogues of the drug Biseptol 480 active substance are:

• Bactrim;
• Dispon;
• Intrimes;
• Catrimoxazole;
• Trimepsol;
• Cyplin;
• SMETROLIM;
• Orifim;
• Duo-septol;
• Kotrifarm;
• Berlocide;
• Bisutrim.

The price of Biseptol is from 27 to 40 rubles per package of tablets with a dosage of 120 mg and from 80 to 110 rubles - for packing tablets with a dosage of 480 mg.

The drug is released exclusively by the doctor's prescription and is accepted according to its instructions.

To all Who Applies Biseptol 480: Instructions for the use of the specified drug must be carefully studied! The dosage prescribed by the doctor, in no case should be exceeded, otherwise there is a significant risk of developing side effects.

Photo of drug

Latin name: Biseptol

ATX code: j01ee01

Active substance: Ko-trimoxazole [sulfamethoxazole + trinmet]

Manufacturer: Abianice Pharmaceutical Works Polfa (Poland), Medana Pharma Terpol Group J.S., Co. (Poland)

Description Actual on: 02.11.17

Biseptol - Combined antibacterial drug.

Active substance

Sulfamethoxazole and trimethopris.

Release form and composition

Available in the form of tablets and suspension for intake. Tablets are implemented at 14 or 20 pieces in a blister. In packing 1 or 2 blisters. The suspension is made in bottles of dark glass with a volume of 80 ml.

Indications for use

• Respiratory tract infections: sharp, chronically bronchitis, pneumonia, bronchiectatic disease, spheres of pleura, lung abscess (nonspecific inflammation of lung tissue).
• Urinary tract infections: prostatitis, pylitis, gonoxococcal urethritis, chronic pyelonephritis.
• PCT infections: cholera, diarrhea, dysentery, abdominal typhoid.
• Skin and soft tissue infections: - pyodermia (purulent damage to the skin).

Contraindications

• increased sensitivity to the components of the drug;
• aplastic anemia (cessation of growth and ripening of erythrocytes, platelets and granulocytes);
• leukopenia;
• B12 deficient anemia;
• Agranulocytosis.

Instructions for use Biseptol (method and dosage)

Pills

Tablets are accepted inside after eating. Wrapped with sufficient liquid. The dosage establishes the doctor, taking into account the individual testimony of the patient.

• Children 3-5 years old are prescribed 240 mg 2 times a day. Children are 6-12 years old - 480 mg 2 times a day.
• In the treatment of pneumonia, the daily dose is calculated: 100 mg of sulfamethoxazole per 1 kg of body weight. Take the drug every 6 hours. The duration of therapy is 2 weeks.
• For the treatment of gonorrhea, 2 g of sulfamethoxazole is prescribed 2 times a day with an interval of 12 hours between the receptions.
• Adults and children over 12 years old are 960 mg 2 times a day. With a long course of treatment - 480 mg 2 times a day.
• The duration of therapy is from 5 to 14 days. For severe course Or in chronic infections, an increase in one-time dose may be required by 30-50%.
• If the therapy lasts more than 5 days or the patient takes increased doses of the drug, it is necessary to control peripheral blood. In the case of pathological changes, the reception of folic acid is prescribed at a dose of 5-10 mg per day.
• When passing a dose passage, the drug should be taken as early as possible. If you want to take a double dose, the previous dose should be skipped. You cannot take a double dose to compensate for the missed.
• For renal failure (QC 15-30 ml / min) The recommended dose is reduced by 2 times. With QC less than 15 ml / min apply the drug is not recommended.

Suspension

Biseptol in the form of a suspension is taken inside, after eating with a sufficient amount of liquid.

• Adults and children over 12 years old take 960 mg every 12 hours. With severe flow infections, the dose increases to 1440 mg every 12 hours.
• The duration of the treatment of infection urinary tract is 10-14 days, exacerbation chronic bronchitis - 2 weeks, diarrhea of \u200b\u200btravelers and shgelles - 5 days. The minimum dose is 480 mg every 12 hours. With the duration of treatment, more than 14 days is used minimum dose.
• Children from 2 months (or 6 weeks at birth from mothers with HIV infection) up to 5 months take 120 mg 2 times a day. Children from 6 months to 5 years are taken by 240 mg at intervals at 12 o'clock. Children 6-12 years old are prescribed 480 mg every 12 hours.
• The duration of therapy of urinary tract infections and acute otitis - 10 days, shgelles - 5 days. In treating heavy infections Children dose can be increased by 2 times.
• Minimum length of therapy acute infections - 5 days. After the symptoms disappear, the therapy needs to be continued for another 2 days. If after 2 week does not occur improves, you need to be reused.
• Soft Shankr - 960 mg every 12 hours. If the skin element is not healing after 7 days, you can extend the reception of the drug for another 7 days. The lack of effect may indicate the resistance of the pathogen.
• With acute uncomplicated infections of urinary tract in women, a one-time reception is 1920-2880 mg. Take the drug is recommended in the evening after eating or before bedtime.
• In the treatment of pneumonia caused by Pneumocystis carinii, prescribe 30 mg per 1 kg of body weight 4 times a day with an interval of 6 hours. Therapy duration - 2-3 weeks.
• For adults and children over 12 years old are prescribed 960 mg per day. The total daily dose for children under 12 years old should not exceed 1920 mg. Reception is carried out for 3 days in a row every week.
• With others bacterial infections The dose is selected individually taking into account age, body weight, kidney functions and the severity of the disease. With the nocardiosis, adults take 2880-3840 mg per day for at least 3 months. Course treatment during acute brucellosis - 3-4 weeks.

Side effects

When taking the drug, the following side effects are possible:

• headaches, depression, tremor, apathy, dizziness, aseptic meningitis and peripheral neurites - from the nervous system;
• from the respiratory system: pulmonary infiltrates, bronchospasms;
• from the digestive system: a decrease in appetite, nausea, vomiting, abdominal pain, diarrhea, gastritis, glossite, stomatitis, hepatitis, pseudomambranous enterocolitis;
• from side blood system: leukopenia, thrombocytopenia, megaloblastic anemia, neutropenia, agrunolocytosis;
• from the urinary system: a violation of the functioning of the kidneys, polyuria, an increase in the concentration of urea, hematuria, crystalluria;
• on the part of the musculoskeletal system: Malgy, Arthralgia.

Overdose

Symptoms of overdose:

• nausea,
• vomiting
• intestinal colic
• dizziness,
• headache,
• drowsiness,
• depression,
• fainting
• confusion of consciousness
• fever,
• crystalluria.

If for a long time to take high doses of the drug, thrombocytopenia, leukopenia, megaloblastic anemia and jaundice are observed.

In this case, the stomach, forced diuresis, is prescribed, urine acidification increases the removal of trimethopril, according to hemodialysis.

Analogs

Analogs in the ATX code: Bactrim, Grosptol, Dvsenptol, Orifim, Septrine.

Do not make a decision on replacing the drug yourself, consult your doctor.

pharmachologic effect

Bispetol has bactericidal (the destruction of bacteria) and bacteriostatic (obstacle to the reproduction of bacteria) properties. The drug is effective against staphylococci, streptococci, intestinal sticks, pneumococci, abdominal chopsticks, dysentery and proteins.

It does not apply in the fight against tuberculosis microbacteria, spirochete and a cinema stick. The drug is quickly absorbed during oral administration. The maximum content of bispetol components in the blood is achieved within 3 hours after the reception. The effect is saved for 7 hours.

The highest content of the components of the drug is noted in lungs and kidneys. Excreted from the body during the day with urine.

special instructions

Caution in the use of bispetol should be observed by people suffering from alcoholism, with a nutritional and absorption disorders.

To prevent crystalluria during therapy, it is recommended to drink a sufficient amount of liquids, it will warn and block the kidney channels.

During pregnancy and breastfeeding

During the period of pregnancy and lactation, the reception of the drug is contraindicated.

In childhood

Biseptol can prescribe to children over 3 months.

Children born from mother with HIV infection, the drug can assign after 6 weeks of life.

When yellowing in children, the use of the drug is prohibited.

In old age

Apply with caution.

With violations of the kidney function

In renal failure, the drug is not prescribed.

When violations of the liver function

Patients with hepatic insufficiency Reception is contraindicated.

Medicinal interaction

• Combined with thiazide diuretics there is a risk of thrombocytopenia and bleeding.
• Sulfamethoxazole and trimethopris increase the anticoagulant activity of indirect anticoagulants, as well as the effect of hypoglycemic drugs and methotrexate.
• Biseptol reduces the intensity of the hepatic metabolism of phenytoin and warfarin, reinforcing their action.
• Combined with diuretics increases the risk of thrombocytopenia.
• Benzocaine, plot, procainamide (like others medicinal productsAs a result of the hydrolysis of which PABK is formed) reduce the efficiency of the drug.
• Phenytoin, barbiturates, Pasca enhance the manifestations of folic acid shortage in combination with bispetol.
• Derivatives salicylic acid Increase the effect of the drug.
• Ascorbic acid, hexamethyleneteramine increases the risk of crystaluria when taking Biseptol.
• In combination with drugs that depress bone marginal blood formation, the risk of myelosuppression increases.
• It may increase the content of digoxin in the blood plasma in some elderly patients.
• After the kidney transplantation, when taking Biseptol, there is a passing disruption of the transplanted kidney function.
• Reduces the effectiveness of oral contraceptive drugs.