ACC (Acetylcysteine) is a drug with an expectorant and mucolytic effect, which is prescribed to liquefy the viscous secretion of the bronchi in diseases of the respiratory system, which occur with the formation of thick, difficult sputum.

In this article, we will consider why doctors prescribe Azz, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Azz can be read in the comments.

Composition and form of release

The active ingredient Azz is acetylcysteine. The following types of the drug are produced:

1. Effervescent tablets ACTS 100, ACTS 200 and ACTS Long, containing 100 mg, 200 mg and 600 mg of acetylcysteine, respectively;
2. Granules for the preparation of a solution for oral administration of ACC, one packet contains 100 or 200 mg of acetylcysteine ​​- granules with an orange scent, 200 or 600 mg active substance- granules with the smell of lemon and honey;
3. Orange granules for preparation of syrup for oral administration of ACC. 5 ml of the finished syrup contains 100 mg of acetylcysteine.
4. Solution for intramuscular and intravenous administration of ACC Inject, 1 ml of which contains 300 mg of acetylcysteine.

Clinical and pharmacological group: mucolytic drug.

What helps Azz?

The main indications for use are:

• acute or chronic sinusitis;
• respiratory disease;
• acute and chronic, as well as obstructive bronchitis;
• pneumonia;
• tracheitis;
• lung abscess;
• bronchial asthma;
• otitis media.

pharmachologic effect

The active ingredient is acetylcysteine, a cysteine ​​derivative (amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of mucopolysaccharides of sputum. This depolymerizes mucoproteins and increases the viscosity of bronchial secretions.

As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (detoxifying effect is possible due to increased production of glutathione).

Instructions for use

The tablet should be dissolved in water (100 ml) and taken immediately after preparation. In exceptional cases, it is permissible to store the solution for a maximum of 2 hours. It is taken after meals with additional water.

• For children aged 2 to 5 years, the drug is recommended to take 1 tab. (ACC 100) or 1/2 tab. (ACC 200) 2-3 times / day, which corresponds to 200-300 mg of acetylcysteine ​​per day.
• Children aged 6 to 14 years old are recommended to take 1 tab. (ACC 100) 3 times / day, or 2 tab. (ACC 100) or 1 tab. (ACTS 200) 2 times / day, which corresponds to 300-400 mg of acetylcysteine ​​per day.
• Adults and adolescents over 14 years of age are recommended to prescribe the drug 200 mg 2-3 times / day (ACC 100 or ACC 200), which corresponds to 400-600 mg of acetylcysteine ​​per day, or 600 mg (ACC Long) 1 time / day.

For short-term colds the duration of admission is 5-7 days. In chronic bronchitis and cystic fibrosis, the drug should be used for a longer period to prevent infections.

Contraindications

You can not use the drug in such cases:

• hypersensitivity to acetylcysteine ​​or any other ingredients of the medicine;
• exacerbation peptic ulcer;
• pulmonary bleeding;
• pregnancy and breastfeeding;
• glucose-galactose malabsorption;
• hemoptysis;
• lack of lactase, lactose intolerance by the body;
• child's age up to 2 years.

Side effects

ACCs are generally well tolerated; when they are taken orally in the form of a solution, a number of side effects can develop, which include:

• From the side of the cardiovascular system - tachycardia (increased heart rate), arterial hypotension (decrease in the level of systemic blood pressure).
• From the digestive system - nausea, sometimes vomiting, heartburn, upset stools in the form of diarrhea (diarrhea).
• From the central nervous system – headache, noise in ears,
• Allergic reactions are rare, the severity may vary. Manifest in the form of a rash on the skin, itching, urticaria (rash and swelling of the skin, outwardly resembling a nettle burn). In extremely rare cases, there may be a reaction from the bronchi in the form of their spasm, resembling an attack of bronchial asthma.

With very severe course an allergic reaction develops anaphylactic shock with the development of multiple organ failure against the background of a progressive decrease in systemic blood pressure.

With an erroneous or deliberate overdose, phenomena such as diarrhea, vomiting, stomach pain, heartburn and nausea are observed.

Pregnancy and lactation

Due to insufficient data, the use of the drug during pregnancy is contraindicated. If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be resolved.

Analogs

Analogous drugs ACC - ACC Long, Fluimucil, Acetylcysteine, Acetal, Acestad, Acestin, etc. Only a specialist should choose the optimal drug.

Quite often, doctors prescribe to their patients the drug "ACC" ("ACC") for coughs. Instructions for the use of this remedy, as well as its contraindications, indications and side effects will be presented in this article. In addition, we will tell you about the form in which the mentioned medicine is produced, what patients say about it, how much it costs, and so on.

Packaging of the drug, its form of release, composition

Do you know in what form the "ACC" ("ACC") cough medicine is produced? The instructions for use inform us that this drug produced in two different forms... Let's consider them in more detail:

• Medication "ACC" is a powder (granular) intended for the preparation of a solution. This medicine should only be taken by mouth. One 3 gram sachet of powder can contain 200, 100, or 600 mg of acetylcysteine. There are 10, 6 or 20 sachets in a cardboard box.
• The drug "ACC" - effervescent tablets. There can be 20, 10, 100 or 50 pieces in aluminum or cardboard tubes. One tablet contains 600, 200 or 100 mg of acetylcysteine. As for the auxiliary components, they include citric acid anhydride, ascorbic acid, mannitol, lactose anhydride, blackberry flavor and saccharin.

Pharmacological action of the drug

What is the "ACC" ("ACC") cough remedy? The instructions for use claim that this is a mucolytic drug. Due to the fact that there are sulfhydryl groups in the structure of the acetylcysteine ​​molecule, this causes the disulfide bonds of mucopolysaccharides (acidic) sputum to rupture. As a result of this effect, the viscosity of the mucus is noticeably reduced in the patient.

The drug in question has a mucolytic effect, and also facilitates the discharge of sputum due to a direct effect on its rheological properties. This remedy remains active even in the presence of purulent mucus.

The medicine "ACC", the instruction of which is presented below, is very often used in preventive purposes... In this case, there is a decrease in the severity and frequency of exacerbations in patients with cystic fibrosis and chronic bronchitis.

Pharmacokinetics of the drug

What pharmacokinetic properties does ACC have? The instruction does not contain such information. This is due to the fact that pharmacokinetic studies of this medication have not been conducted.

Medicinal product "ACC": indications

The drug in question is prescribed for the following deviations:

• acute and chronic sinusitis;
• diseases of the respiratory system, which are accompanied by the formation of difficult and viscous sputum (for example, with bronchiectasis, acute and chronic bronchitis, cystic fibrosis, obstructive bronchitis, pneumonia, bronchial asthma and bronchiolitis);
• otitis media.

Contraindications

In the presence of any deviations, in no case should the medical preparation "ACC" (powder and effervescent tablets)? Contraindications to the use of this remedy are the following conditions:

It should also be noted that this medication is prescribed with extreme caution to patients with varicose veins of the esophagus, adrenal diseases, renal and / or hepatic insufficiency.

Mode of application

How should I take ACC for cough? The instructions for use contain the following instructions on this matter. For adolescents and adults, it is prescribed 200 mg three times a day. Children from 6 to 14 years old should take the medicine 100 mg three times a day. For children from 2 to 5 years old, the medication is prescribed 1 tablet (100 mg) twice a day. With such a deviation as cystic fibrosis, a child over 6 years old is given 2 tablets of the drug (100 mg each) three times a day. As for babies from 2 to 6 years old, they should take a medication of 100 mg four times a day.

Patients weighing more than 30 kg with cystic fibrosis can increase the dosage to 800 mg per day.

With a short-term nature, the duration of therapy with the presented medication is 5-7 days. With cystic fibrosis and chronic bronchitis, the agent must be used for a longer time (for the prevention of infections).

How should I take ACC 200? The instruction says that this drug should be used only after meals (in order to avoid negative effects on the gastric mucosa). It should be especially noted that additional fluid intake enhances the mucolytic effect of the drug.

Effervescent tablets must be dissolved in half a glass of plain water before use. The prepared solution should be used immediately. In exceptional cases, it can be left for 2 hours.

Overdose

In case of deliberate or mistaken drug overdose, the patient has symptoms such as vomiting, stomach pain, diarrhea, heartburn and nausea. Until now, no serious and life-threatening side effects have been observed.

Drug interactions

What happens if you take any medications and the "ACC" product at the same time? Experts say that combined treatment can cause a number of undesirable reactions. Let's consider them a little further.

With the simultaneous use of acetylcysteine ​​and others, mucus stagnation, dangerous to health, may occur (due to suppression of the cough reflex).

During the simultaneous administration of nitroglycerin and acetylcysteine, there is a possibility of an increase in the vasodilating effect of the former.

There is a synergism of acetylcysteine ​​with the simultaneous use of bronchodilators.

Acetylcysteine ​​is able to reduce the absorption of penicillins, cephalosporins, and tetracycline. In this regard, they must be taken orally 2 hours after taking the first.

Acetylcysteine ​​is not compatible with antibiotics such as Penicillin, Erythromycin, Cephalosporin, Tetracycline and Amphotericin, as well as proteolytic enzymes.

Upon contact of acetylcysteine ​​with rubber and metal, sulfides are formed, which have a characteristic odor.

special instructions

With bronchial asthma, the drug in question should be prescribed with extreme caution. This requires systematic monitoring of bronchial patency.

If, after taking the medication, the patient develops side effects, then it is necessary to stop taking the drug and immediately consult a doctor.

When treating patients with diabetes mellitus it should be borne in mind that 1 effervescent tablet corresponds to 0.006 XE.

To date, information about negative impact drugs (in recommended dosages) on the ability to drive a car, as well as perform other activities that require special concentration, no.

Expiration date and storage methods

The drug in question should be stored only in a dry place inaccessible to small children. In this case, the air temperature should not be higher than 25 ° С. Shelf life medicinal product is three years old. After this time, the use of the medication is prohibited.

After taking the effervescent tablet, the plastic or aluminum tube must be tightly closed.

Price and analogues of the drug

The price of the "ACC" tablet may be different, depending on the pharmacy network, as well as on the markup for the goods. However, on average, such a medicine costs about 75-150 Russian rubles. The price of granular powder is similar to effervescent tablets.

How can you replace the agent in question? Pharmacy chains have a huge number of analogues of the drug, as well as drugs with a similar effect (expectorant, mucolytic). Among the most popular, I would like to highlight the following medicines: "Acestin", "Acetylcysteine", "Vicks Active ExpectoMed", "Mukobene", "Mukomist", "Mukoneks", "N-AC-Ratiopharm", "Fluimucil", "Exomyuk 200" , "Acestad", "Lazolvan", "Ambrobene", "Ambroxol", "Mukosol", "Bronkatar", "Solvin", "Bromhexin", "Gedelix", "Mukaltin", "Prospan", "Stoptussin", " Ascoril "," Linkas "and others.

Everyone knows such a remedy as ACC for cough; instructions for use are necessarily attached to the drug.

The dosage of the drug can be different - 100, 200 and 600 mg each. More modern counterpart drug - ACTS Long. The tool works for almost 12 hours, you can take it no more than 2 times a day.

ACC is available in different forms:

• granules that, after dissolving, turn into syrup;
• inhalation mixture;
• powder for preparing a hot drink;
• a solution that is used for internal injection.

Effervescent tablets are the most convenient option.

Important! Before purchasing a medicine, you need to consult your doctor.

It should be remembered that in each form there is a certain amount of this or that substance. Most of the additional components are contained in the syrup, in addition to the main ingredients, it contains:

• sodium carmellose;
• flavoring;
• sodium benzoate, etc.

The tablets contain lactose, citric acid, flavorings and many other components.

You need to consult with your doctor about which form of ACC to choose. The specialist will establish an accurate diagnosis and prescribe the remedy in the form that is right for you.

Properties of the drug

The potential of this drug has not been fully explored. The tool is used as a mucolytic, expectorant, antioxidant. It allows you to effectively reduce the level of intoxication in the patient's body, liquefies phlegm, and also quickly removes it. With regular medication, the patient not only decreases the level of intoxication, but also fights against the virus itself.

Most often, ACC is taken for colds, especially those that are accompanied by a cough.

There are a number of diseases in which doctors prescribe ACC in any case, these are:

• pneumonia;
• sinusitis of any form;
• bronchitis;
• cystic fibrosis;
• otitis media.

The drug is prescribed for a wet cough. If the patient has a dry type, then first, drugs are used that contribute to the liquefaction of sputum and an increase in the volume of its excretion, after which ACC is prescribed. This is stated in the description of the medication, the instructions for use say that this ACC cough powder is effective only with a wet type. If you take it with a dry cough, then the process of sputum production will begin to be stimulated, which is effective only at the beginning of development. viral infection... As a result, a dry cough develops into a wet cough.

It is important to remember that after application, the remedy begins to act only after an hour. It is excreted from the body in the urine. Before you start taking it, you need to undergo a complete examination. In case of kidney problems, the drug will be excreted much longer, respectively, the daily dose of the drug should be reduced.

But kidney problems are not the only reason why ACC should be treated with extreme caution.

This list includes the following pathologies:

• pulmonary bleeding;
• peptic ulcer;
• the presence of hepatitis;
• special sensitivity to the components that make up the drug;
• pulmonary insufficiency;
• lactation in women;
• pregnancy.

The drug should be taken only after a doctor's prescription and under his strict supervision.

Important! You should always take into account the individual characteristics of the organism.

The manufacturer himself speaks about this. He does not exclude the possibility that any patient may experience side effects... If you find a malfunction in the body, you should immediately contact a specialist.

This medicine is available in several forms. There is an ACC for cough for children in babies of different age categories. Before starting treatment, you need to very seriously study the instructions for use and be examined by a doctor.

When is treatment canceled?

The drug affects each person in a different way. There is a certain possibility that a particular patient may develop an individual intolerance to this medication, which may have the following manifestations:

• headache;
• sensation of tinnitus;
• severe nausea;
• vomiting is possible;
• heartburn and more.

Each instruction speaks of a possible individual intolerance. For example, the instruction for the use of ACC Long for coughing tells in detail what can occur from excessive intake allergic reaction in the form of a rash and redness of the skin. Most often, this remedy is taken with a dry cough.

It should be borne in mind that for children and adults there are separate drug groups... An adult product should not be given to a child. It should be remembered that for patients of different age groups, it is important to correctly adjust the dose of the medication. Only a doctor will prescribe exact dosage and will develop a regimen for taking this remedy.

Admission rules

The medicine is a versatile and fairly cheap way to cure a cough. For example, the instruction for the use of ACC 100 for coughing says that this remedy can be taken even by children, it is allowed to use it for newborns. The appointment schedule depends on the disease the patient is suffering from. Before starting treatment, you need to consult a doctor in advance and undergo a full examination.

The dosage and frequency of administration increase with the age of the patient. It is best to drink the medicine after meals.

ACTS 200 is taken exclusively in the form of a solution, prescribed to patients over 6 years old. The powder is dissolved in warm water, juice, compote or tea.

There is an ACC cough syrup, the instructions for the use of this medication says that it can also be produced in the form of granules that dissolve in a glass of warm water, resulting in a medicinal syrup.

If we talk about how long it takes to take the medicine, then it all depends on the diagnosis. Usually the course of admission is at least 5 days. If the case is very advanced, the treatment can take a long time.

Why do doctors often prescribe ACC?

It should be noted that quite often doctors prescribe ACC to their patients. This is due to the fact that the drug has very good mucolytic properties and contains the following components:

• vitamin C;
• lemon acid;
• sodium citrate;
• acetylcysteine, etc.

As a result of regular medication, patients notice that the mucus that is secreted by the bronchi and lungs becomes less viscous. That is why phlegm leaves the body very easily and is simply excreted. This is very important if the patient has purulent sputum.

The medicine is very useful for preventive purposes.

In addition to the contraindications indicated above, people who have a predisposition to varicose veins veins of the esophagus, and people with diseases associated with the work of the adrenal glands and liver.

This medicine can be given to children. Given the fact that it has a low cost, the tool is available to everyone.

Interaction with other drugs

Many are interested in the question of what happens if this drug is taken along with other drugs. Based on the reviews of experts, it becomes clear that a combined intake, along with a number of other drugs, can cause a negative reaction.

For example, if taken with other antitussives, very dangerous mucus stasis can occur. This is due to the fact that ACC has a mucolytic effect, and the antitussive agent inhibits cough, mucus is secreted, but cannot leave the body.

If you combine it with nitroglycerin, too active vasodilation may begin.

In combination with bronchodilators, ACC can cause synergism; it cannot be combined with antibiotics such as:

• Erythromycin;
• Amphotericin;
• Penicillin.

Powder, tablets or granules must be dissolved in water before taking. For this, only glass containers are used.

That is why, before starting treatment with this remedy, you should be examined by a doctor.

What should be remembered when taking the drug?

The tool has a very good therapeutic effect... But in any case, like all other medicines, it should be taken only after prior consultation with a doctor and in a specific dosage.

The most high concentration medicinal components noted in the ACC 600 for cough, the instructions for the use of this medication says that it can only be taken by adults. Children can drink ACC 100.

Patients with a number of pathologies should be very careful when using this medication, otherwise even more negative consequences may arise.

Attention! Patients who take not only this drug, but also other drugs for the treatment of a viral infection or other diseases should first consult a doctor. Only then can treatment begin.

Pharmachologic effect:
The active ingredient is acetylcysteine, a cysteine ​​derivative (amino acid). It has a mucolytic, expectorant effect due to the rupture of bisulfide bonds of mucopolysaccharides of sputum. This depolymerizes mucoproteins and increases the viscosity of bronchial secretions. As a result, mucociliary clearance increases and sputum discharge improves. Acetylcysteine ​​has an antioxidant and pneumoprotective effect, which is associated with the binding properties of sulfhydryl groups. It is an antidote for acute poisoning with aldehydes, paracetamol and phenols (detoxifying effect is possible due to increased production of glutathione).

When used internally, acetylcysteine ​​is almost immediately completely absorbed from gastrointestinal tract... The active metabolite is cysteine, which is produced in the liver. Further, the metabolism of acetylcysteine ​​passes through the formation of diacetylcysteine, cystine. The end product of metabolism is mixed disulfides.

Bioavailability is 10%. Cmax is determined for internal use after 1-3 hours. Plasma proteins bind 50% of acetylcysteine. The maximum concentration of a pharmacologically active metabolite in the blood is 2 μmol / L.

Inactive metabolites are excreted in the urine (inorganic sulfates, diacetylcysteine), however, a non-standard amount of acetylcysteine ​​is excreted in the feces unchanged.

The half-life of acetylcysteine ​​depends on biotransformation in the liver. With liver failure, it is 8 hours, while in the norm - 1 hour. It passes through the hematoplacental barrier and can accumulate in the fetal waters.

ACC (ACC) method of administration and dosage:
The daily dose for the treatment of cystic fibrosis in patients weighing more than 30 kg is used up to 800 mg.
Children from the 10th day of life and up to 2 years old are used 50 mg 2-3 r / s.
At the age of 2-5 years - 400 mg per day, divided into 4 doses.
From 6 years old - 600 mg / s (divided into 3 doses). Treatment is continued for a long time, in courses of several months (3-6).
In all other cases daily dose for kids from 14 years old and adults is 400-600 mg.
From 6 to 14 years old - 300-400 mg (divided into 2 doses).
2-5 years - 200-300 mg (divided into 2 doses).
Children from the 10th day of life and up to 2 years old are used 50 mg 2-3 r / s. At acute diseases without complications, the product is prescribed for 5-7 days. In the presence of complications or chronic course course treatment is possible (up to 6 months).

ACC is taken after a meal. The tablet or the contents of the sachet must be dissolved in half a glass of liquid (iced tea, water, juice).

ACC (ACC) contraindications:
Hypersensitivity to acetylcysteine ​​and excipients
Peptic ulcer
Hereditary fructose intolerance
Pulmonary hemorrhage or hemoptysis
V pediatric practice- with hepatitis and renal failure(threat of accumulation of nitrogen-containing products).

ACC (ACC) side effects:
From the gastrointestinal tract - stomatitis, nausea, vomiting, diarrhea, heartburn.
From the side of the central nervous system - headache, tinnitus.
From the CCC side - arterial hypotension, increased heart rate.

Allergic reactions - bronchospasm (especially with bronchial hyperreactivity), rash and itching of the skin. Often the cause of hypersensitivity to the product is the presence of propyl and methyl parahydroxybenzoate in the composition.

Pregnancy:
The embryotoxic effect of acetylcysteine ​​is absent, however, during pregnancy, also with breastfeeding it is prescribed only if indicated under the supervision of a physician.

Overdose:
In pediatric practice, cases of hypersecretion in infants are described. Side effects that threaten life and health are not described. In case of overdose (dyspeptic disorders), symptomatic therapy is prescribed.

Use with other medicinal products:
Tetracycline and its derivatives (except doxycycline) cannot be used together with ACC in pediatrics.
During experimental studies in vitro, there were no cases of inactivation of other types of antibacterial products. Nevertheless, it is recommended to observe the interval between the intake of ACC and the antibiotic of 2 hours (at least). In vitro proved the incompatibility of acetylcysteine ​​with semi-synthetic penicillins, antibiotics of the aminoglycoside and cephalosporin series. Such studies have not been conducted with erythromycin, amoxicillin, and cefuroxime.

The simultaneous use of antitussives can lead to stagnation of the secretions of the respiratory tract.

Application with nitroglycerin may increase vasodilating action in the aftermath of the last.

Release form:
ACC 100, 200- effervescent tablets, 20 pcs.
ACC hot drink- powder for preparing a hot drink for internal use- 200 mg (20 sachets) and 600 mg (6 sachets).
ACC-long- effervescent tablets (600 mg), 10 pcs. in a tuba.
ACC powder for preparation of solution for oral administration - 100, 200 mg, 2 pcs. in a pack.

ACC for children- powder for preparation of a solution for internal administration of 30 g in a 75 ml bottle (20 mg / ml) and 60 g in a 150 ml bottle (20 mg / ml).

Storage conditions:
In places inaccessible to babies. Temperature no more than 30 ° С. The finished solution should be stored for no more than 12 days in the refrigerator (at a temperature of 2-8 ° C).

ACC (ACC) composition:
Effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sucrose, saccharin, flavoring).

Powder: acetylcysteine ​​and auxiliary components (sucrose).

ACC Long effervescent tablets: acetylcysteine ​​and auxiliary components (ascorbic acid, sodium citrate, saccharin, sodium cyclamate, lactose, citric acid, sodium carbonate, mannitol, sodium bicarbonate, flavoring).

ACC for children: acetylcysteine.

Additionally:
Carefully apply ACC for gastric ulcer or duodenum.

When preparing a solution, a patient with bronchial asthma can inhale air with particles of the product, which causes irritation of the mucous membrane of the upper respiratory tract and can provoke reflex bronchospasm.

For the best mucolytic effect during the treatment with acetylcysteine, you must take a lot of fluids.

10 ml of the finished oral solution contains 0.31 carbohydrate units, which should be taken into account by patients with diabetes mellitus.

Sorbitol has a mild laxative effect on stools.

For newborns and children under 1 year of age, acetylcysteine ​​is used exclusively for health reasons under strict medical supervision. The recommended dosage (10 mg / kg body weight) must not be changed.
ACC 200 is not used under the age of 2 years.
ACC Long is not recommended for children under 14 years of age.

The speed of reaction when driving and working with equipment does not change when taking acetylcysteine.

Attention!
Before using the medication "ACC (АЦЦ)" it is necessary to consult a doctor.
The instruction is provided solely for acquaintance with " ACC (ACC)».