Trancam - means that is used in abundant blood formation and bleeding in the uterine cavity. Instructions for use does not exclude the use of the drug at other bleeding, but under the strict control of the attending physician.

A task medical - cope with active blood generation and minimize further allocations and bleeding from the genital tract. Clinical - pharmacological classification Tranxam - a remedy with antitumor and hemostatic effect. The drug is a fibrinolysis inhibitor, which is the process of transition plasminogen in plasmin, which contributes to serious blood generation.

For the most part, the transcases are used to stop the uterine bleeding

Structure

Active ingredient - transcamic acid, additional - hypronzes, talc, hypimosellos, silicon colloidal dioxide, as well as calcium stearate and carboxymethyl starch sodium. As an auxiliary substance can be used for injection - if necessary injection.

Active substance:

Transcamic acid.

Manufacturer

"Moscow endocrine plant" - manufacturer, packing and packaging for intravenous solution. Address: Moscow, ul. Novokhokhlovskaya, 25.

OJSC NIPARM is the owner of the registration certificate, as well as an organization that takes complaints of quality. Address: Nizhny Novgorod, ul. Salganskaya, 7.

CJSC Obninskaya Chemical - Faracecetic Company "- Manufacturer of Tablets. Address: Kaluga Region, Obninsk, ul. Queen, 4.

Form release

• tablets one dozen in packing, packaging in small cells, white, the content of the active substance is 250 and 500 mg;
• intravenous solution, 50 ml in one ampoule, packaging - 1 - 2 pcs, packaging in contour type cells.

pharmachologic effect

Tablets and injection fluid in Vienna has anti-inflammatory local actionAnd also stops blood and reduces the risk of appearance.

Pharmacodynamics and pharmacokinetics

The main active component is a transcamic acid that removes the swelling and reduces blood release (system and local effect). During the preparation, cells and bodies are actively suppressed, provoking the appearance of allergies and inflammation processes, both internal and external.

Purchases for uterine bleeding

Before starting a course of treatment, it is recommended to consult with the attending physician - you never know what caused these problems. The cause of pain and bleeding can be the most different: from inflammation to ectopic pregnancy and the most serious disorders of the urogenital system. Often the root of the problem lies in the lack of iron - against the background of the development of anemia.

With violations of the kidney function

In this case, a clear dosage developed by the attending physician is important.

Overdose

At the moment there is no information about overdose.

Interaction

It is necessary to gently apply tractions with such preparations as:

• hemokoagulaz (frequent cases of thromboms);
• an intravenous solution cannot be used with preparations that contain: tetracycline, penicillin, diazepam.

Excluded simultaneous treatment with norepinephrine, deoxyepinephrine hydrochloride.

special instructions

Since the drug course can seriously affect visual acuity and lead to unpleasant consequences, doctors advise to examine the eye bottom of the ophthalmologist, as well as check recognition color Gamma..

Terms of sale

Sold according to individual instructions and recipes attending physician.

Storage conditions

When stored observed temperature mode up to 30 degrees and take care of young children.

Shelf life

3 years from the date of production.

Price of traxam where to buy

Trackersam in any dosage form is available for sale in pharmacies. Tablets - 225 - 250 rubles, intravenous solution - 1500 - 1900 rubles.

Analogs of Treexama

Analogs of the medication: Acid aminocaprona, tagina, trekx and apric.

Reviews about Tranksame

SAMI frequent cause The use of the drug is uterine bleeding for various reasons and pathologies. Women who used this drug ever are actively share their experience in women's forums, websites and blogs, leaving a variety of reviews.

If you believe the statistics, this tool helps to get rid of the serious problem of bleeding quickly and trouble-free, regardless of the dynamics of the disease. As for the form of the drug - tablets or intravenous solution - the treatment method in this case is selected individually, based on the problem.

One of the patients was diagnosed by the turbine detachment, after which abundant bleeding began. Comprehensive treatment The transcama with Duphaston soon gave a positive result: well-being improved significantly, the discharge stopped.

Gently, but the transcases are used even during pregnancy at different times. The medicine is used in abundant and painful discharges. What is characteristic, the drug is not addictive.

Doctors warn that it is impossible to deal with self-medication during bleeding, it is urgent to seek help to doctors!

And most importantly, it is important to remember that the transcases do not work if the treatment of problems is written to illiterately - blood releases depend on the hearth disease, which must be treated first.

Instructions for use:

Tranxam is a drug related to a group of hemostatic drugs.

Pharmacological action of transkamama

Trancam is a fibrinolysis inhibitor. It has an antifibrinolytic effect and prevents plasminogen conversion to plasmin. In the instructions for the transkamam, it is noted that this drug has a good systemic and local hemostatic effect. Its use is especially effective in bleeding, accompanied by an increase in the blood content of fibrinolysin, for example, in platelets or menorragia. In addition, according to reviews, anti-inflammatory, antitumor and antiallergic action is capable of providing transactions.

This drug is well and evenly distributed quite evenly in all tissues of the body, is able to penetrate the hematorecephalic and placental barrier. After receiving the transkama in tablets, its maximum blood concentration is marked after three hours. Therapeutic concentration in tissues is saved for about 17 hours.

In case of violation of the kidney function, cumulation can be observed in the body of a transcamic acid patient.

Instructions for use

As a hemostatic preparation, tractions are used in the following cases:

• To prevent the development of bleeding due to increased systemic content of fibrinolysin, as well as for their treatment (bleeding during pregnancy, liver disease, malignant neoplasms of the prostate and pancreatic glands, manual departments of the last, postpartum bleeding, operations and early postoperative period, chorion delay, leukemia, hemophilia );
• For the prevention and treatment of bleeding caused by local activation of fibrinolysin (the extraction of teeth in patients suffering from hemorrhagic diathesis, hematuria, gastrointestinal bleeding, nasal and uterine bleeding).

According to the instructions, the transcases can be used as an anti-allergic agent for the treatment of allergic dermatitis, urticaria, eczema. Also, the transcases can be used in complex therapy angioedema edema (feeding of quinque).

According to transfers, due to their anti-inflammatory properties, it is a fairly effective drug in the treatment of stomatitis, laryngitis, pharyngitis and annets.

Methods of use of Tranxama

Tablets in tablets take:

• With repeated nose bleeding three times a day of 1.0 g for 7 days;
• For royal bleeding - 1.0 g every six hours for three days;
• After the extraction of the tooth in patients with hemorrhagic diathesis, for the prevention of secondary bleeding, the transcases in tablets are prescribed at the rate of 25 mg / kg 4 times a day for a week;
• For the treatment of hereditary angioity edema, the drug is prescribed by courses or constantly 1.0 g twice a day;
• IN postoperative period 1.5 g three times a day for 10 to 14 days.

The transcases for intravenous drip or inkjet administration are usually used to stop massive bleeding, as well as bleeding arising during surgery. Before removing the tooth, patients with impaired blood coagulation The drug is also administered intravenously, and after extraction are prescribed to the Tablets.

Side effects of Treexama

In the instructions for the transkamam notes that the use of this medicinal preparation It can lead to the development of the following adverse reactions:

• Decline in appetite, nausea, vomiting, heartburn, diarrhea;
• Drowsiness, violation of color and vision, weakness, dizziness;
• Thromboembolism, thrombosis, pain in chest, tachycardia;
• Urticaria, skin rash, itching.

According to the reviews of the transfers with rapid administration, it can lead to the development of arterial hypotension.

Contraindications

According to the instructions, Tranksams are contraindicated in the following cases:

• Subarachnoid bleeding;
• Individual intolerance to the drug.

With extreme caution, the transcons should be used in the treatment of patients with myocardial infarction, deep vessels or brain vessels, as well as renal failure.

The use of transkama during pregnancy is permissible only in cases where its benefit for the mother's body significantly exceeds possible risk Negative influence on the fruit.

Interaction of transceum with other means

The transcases in the form of a solution for intravenous administration cannot be mixed with blood preparations, hypertensive means, urchinase, penicillin, diazepam, tetracycles. With the simultaneous purpose of the transmission with other hemostatic preparations, a sharp increase in the activity of the thrombosis process is possible.

Release form and storage conditions

The transcases are produced in the form of tablets coated with a shell and an ampulon solution intended for intravenous administration. The drug is stored in a cool, dry and dark place inaccessible to children. The shelf life of the transkama is three years.

The preparation includes an active ingredient: transcamic acid.

Additional components of the drug in tablets: Mcz, Talc, Hypronza, calcium stearate, sodium carboxymethyl starch, silicon colloidal dioxide, macrogol.

The auxiliary substance of the solution to Vienna: water for injection.

Form release

Available in transcases in the form of tablets and a solution for administration to Vienna. Tablets with content active component 250 and 500 mg are packaged in contour cells of 10 pieces, 1, 2, 3, 5 cells in the package.

The solution for administration is packaged into ampoules 50 ml, 5 pieces in the contour cells, 1-2 per pack.

pharmachologic effect

The solution and tablets of transcases possess antifibrinolytic, hemostatic, antiallergic and anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

The main component of this drug, transcamic acid is an antifibrinolytic substance inhibiting activity prebinolysin or plasminogen , contributing to its subsequent transformation into fibrinolysin or plasmin. At the same time, the local and systemic hemostatic effect needed during bleeding, which causes high content fibrinolysis characteristic of pathology and menorgia.

Also marked Anti-inflammatory, anti-allergic, anti-infectious and antitumorian The action that is ensured by suppressing the production of kinines and other active peptides participating in inflammatory and allergic processes. The transkamic acid has its own analgesic effect, but also stimulates the analgesic activity of opiates.

Inside the body, the drug is exposed to medium absorption, slightly binding to plasma proteins. The main substance is evenly distributed in the tissues, penetrates through the placental barrier, falls into breast milk. Also, the drug can be detected in the seed fluid, which lowers fibrinolytic activity, without affecting the movement of spermatozoa. The preservation of the antifibrinolytic concentration in the body tissues is 17 hours, and in plasma - about 7-8 hours. It is only at a small extent. From the body, the drug is excreted using kidneys for 12 hours.

Indications for use

The main indications for the use of tablets of transcases are bleeding or the likelihood of their development due to:

• strengthening fibrinolysis of local manifestation, i.e. uterine, nasal, gastrointestinal tract, hematuria, dental, gynecological and so on;
• strengthening generalized fibrinolysis, namely because of the appearance malignant neoplasms in the area of \u200b\u200bthe pancreas or prostatic gland, operational interventions on the chest, , postpartum bleeding, liver diseases;
• hereditary , allergic diseases , such as: , rash and irritation;
• bleeding at;
• inflammatory diseases, for example: , .

• bleeding or probability of their development due to the strengthening of various fibrinolysis;
• operational interventions on bladder bubble;
• operations with systemic inflammatory reactions, for example, sepsis, peritonitis, heavy I. middle severity, various shock conditions and so on.

Contraindications

Application of the drug is contraindicated with:

• subarachnoid hemorrhage;
• high sensitivity to it.

Combustion of caution is required in the treatment of patients with thrombosis and the threat of their occurrence, thrombohemorrhagic complications, violations of color vision, hematuria from the upper departments of the urinary system.

Side effects

When treating this drug may develop side effects. So, taking pills bloodstream can be felt nauseous, vomiting, , , rash, decrease, and. Also, the violation of color perception is not excluded, in rare cases, it occurs - thromboembolism and.

As for the solution for introducing into Vienna, as a result of its application, development, dyspeptic phenomena, dizziness, weakness, drowsiness, chest pain, hypotension, color violation disorders, odorility spectatic perception, thrombosis or thromboembolism and so on.

Instructions for the use of transkama (method and dosage)

As a rule, Tablets Trackersam instructions for use recommends taking inside.

Dosage and treatment diagram with different violations are established by the attending physician, although there are also standard destinations.

For example, the treatment of local fibrinolysis is carried out at the appointment of 1000-1500 mg to 2-3 times receiving a day.

The therapy of profuse uterine bleeding includes the reception of the drug in the daily dosage of 1000-1500 mg to the 3-4-time reception for 3-4 days.

After the operational intervention of the cervical conization, the tablets are taken in the daily dosage of 1500 mg to the 3-time reception, on average, 12-14 days.

The solution of the drug or ampoule of the transcama instruction on application recommends introducing into a vein. Do it need drip or stroke. For each reading, the doctor prescribes a specific dosage and duration of use. Therefore, the dose and the duration of the use of the drug during menstruation differs, for example, from prescriptions in the treatment of generalized fibrinolysis. There are also various situations in which the dosage correction may be required during the treatment period.

Treexam with menstruation

It should be noted that disorders menstrual cycle There are quite often found. It may be strong painfulness, abundant bleeding, cycle dates failures. All this is not just unpleasant, but also often the development of various violations: inflammation, , , infections of small pelvis organs. At the same time, many women take careful surveys and receive the appointment of a doctor. In general, there are many hemostatic drugs. As the reviews about the transcase show, it is prescribed in the form of tablets during menstruation. The instruction on the drug contains information about the dosage and the length of therapy - one tablet to the 3-4-time reception per day for 3-4 days.

Purchases for uterine bleeding

Many cases are known when uterine bleeding caused iron deficiency, which is also a threat to human health and life. Therefore, under the uterine bleeding, hemostatic tablets are prescribed, including transcases. Of course, without appointing a doctor, it is not worth it, because it is important to establish the causes of violations that can be the most different.

Overdose

Overdose information is not provided.

Interaction

Application with hemostatic preparations and hemokoagulase can stimulate the activity of the thrombosis.

The solution for administration to Vienna has pharmaceutical incompatibility with drugs, some solutions, which include , urchinase, diazepam, Some hypertensive means, for example, Norepinefrin, metairmine batter and DeoxyPinephrina hydrochloride.

special instructions

Prior to the beginning of the therapeutic process, it should be inspected by an oculist to determine the visual acuity, eye examination and color perception.

Terms of sale

On prescription.

Storage conditions

The place for storing the drug does not require special conditions. It is important for it to be unavailable to children at temperatures up to 30 C.

Shelf life

Transaction during pregnancy and lactation

This drug can be prescribed when bleeding during pregnancy. Of course, it is necessary to take medicine only by testimony, given all contraindications. It is known that the main substance easily overcomes the placental barrier and enters into breast milk. However, reviews about Tranxama with women who took this drug contain information that treatment has passed without complications.

The treatment of bleeding during pregnancy passes with the appointment of the drug in the daily dosage of 250-500 mg to the 3-4-time reception. The medicine is accepted until the bleeding is completely stopped, but usually the therapeutic course lasts 7 days.

Analogs of Treexama

The main analogs of the trance: Tingin, acid aminocapronovaya, Trenaksa and .

Alcohol and trance

Take alcohol during the treatment period is prohibited, as it has an undesirable effect on the state of blood.

This article allows you to familiarize yourself with the instructions for the use of the drug. Trancam. The guests of visitors to the site - consumers of this medicine, as well as the opinions of the doctors of specialists in the use of trance in their practice are presented. A big request to more actively add your reviews about the preparation: helped or did not help the medicine to get rid of the disease, which complications were observed and side effects, possibly not stated by the manufacturer in annotations. Analogs of the Taxam in the presence of available structural analogues. Use for the treatment of bleeding during operations during menstruation in adults, children, as well as in pregnancy and breastfeeding.

Trancam - Hemostatic preparation. Fibrinolysis inhibitor. It specifically inhibits the activation of plasminogen and its transformation into plasmin. It has local and systemic hemostatic effects during bleeding related to the increase in fibrinolysis (platelet pathology, menorrhagia).

Due to the suppression of the formation of kinines and other active peptides involved in allergic and inflammatory reactions, has an antiallergic and anti-inflammatory effect.

The experimental studies confirmed its own analgesic activity of transcamic acid, as well as the potential effect on the analgesic activity of opioid analgesics.

Structure

Transcamic acid + excipients.

Pharmacokinetics

When taking inside in a dose of 0.5-2 g, 30-50% of the drug is absorbed. Distributed in tissues relatively evenly (except spinal fluidwhere the concentration is 1/10 from plasma). Penetrates the placental barrier and the hematoreencephalical barrier (GEB), stands out with breast milk (reaching approximately 1% of the concentration in the plasma of the mother). It is found in the seed fluid, where reduces fibrinolytic activity, but does not affect the migration of spermatozoa. Excreted by the kidneys (the main path - glomeric filtering), more than 95% unchanged for the first 12 hours.

Indications

• bleeding or risk of bleeding against the background of a generalized increase in fibrinolysis (bleeding during operations and in the postoperative period, postpartum bleeding, manual separation of the last, chorion detachment, bleeding during pregnancy, malignant neoplasms of the pancreas and prostate glands, hemophilia, hemorrhagic complications of fibrinolytic therapy, thrombocytopenic purpura , leukemia, liver disease preceding streptocinase therapy);
• bleeding or risk of bleeding against the top of the local enhancement of fibrinolysis (uterine, nasal, gastrointestinal bleeding, hematuria, bleeding after prostatectomy, caution of the cervix over carcinoma, tooth extraction in patients with hemorrhagic diathesis);
• hereditary angioedema edema (for tablets);
• allergic diseases, incl. eczema, allergic dermatitis, urticaria, medicinal and toxic rash (for tablets);
• inflammatory diseases oral cavity and pharynx, incl. Tsillit, pharyngitis, laryngitis, stomatitis, affects of the oral mucosa (for tablets);
• operational interventions on the bladder (for solution);
• surgical manipulations with a systemic inflammatory reaction, incl. Sepsis, peritonitis, pancreaticosis, heavy and medium severity of gestosis, shock various etiology (for mortar).

Forms of release

Tablets coated with a shell of 250 mg and 500 mg.

Solution for intravenous administration (injections in ampoules for injection).

Instructions for use and dosage

Pills

The drug is prescribed inside.

Under local fibrinolysis, 1-1.5 g 2-3 times per day are prescribed.

In profuse uterine bleeding, 1-1.5 g 3-4 times a day for 3-4 days are prescribed.

When bleeding against the background of Willebrand disease and other coagulopaths - 1-1.5 g 3-4 times a day for 3-10 days.

After the operation of the conization of the cervix - 1.5 g 3 times a day for 12-14 days.

With nasal bleeding - 1 g 3 times a day for 7 days.

Patients with coagulopathy after the extraction of the tooth - 1-1.5 g 3-4 times a day for 6-8 days.

When bleeding during pregnancy, they are prescribed - at 250-500 mg 3-4 times a day until the bleeding stop. Medium duration Course treatment - 7 days.

With a hereditary angioedema edema - 1-1.5 g 2-3 times a day, constantly or with interruptions, depending on the presence of prolromal symptoms.

With the symptoms of allergies and inflammation - 1-1.5 g 2-3 times a day for 3-9 days, depending on the severity of the state.

In generalized fibrinolysis, therapy begins with parenteral intravenous administration with a subsequent transition to the reception in a dose of 1-1.5 g 2-3 times a day.

Ampoules

Intravenously (drip (dropper), inkjano). In generalized fibrinolysis, a single dose of 15 mg / kg of body weight every 6-8 hours is introduced in a single dose every 6-8 hours, the rate of administration of 1 ml / min. Under local fibrinolysis, the administration of the drug is recommended at a dose of 250-500 mg 2-3 times per day. With prostatectomy or operation on the urinary bubble, 1 g is administered during operation, then 1 g every 8 hours for 3 days, after which they are transferred to the reception inwards to the disappearance of macrohematuria.

With a high risk of bleeding, with a systemic inflammatory reaction at a dose of 10-11 mg / kg 20-30 minutes before intervention.

Patients with coagulopathy before the extraction of the tooth are injected at a dose of 10 mg / kg of body weight, after the extraction of the tooth, a reception is prescribed inside, tableted form of the drug.

In case of violation of the excretory function of the kidney, the dosing regime is necessary: \u200b\u200bat a concentration of creatinine in the blood, 120-250 μmol / l are prescribed by 10 mg / kg twice a day; at creatinine concentration 250-500 μmol / l are prescribed 10 mg / kg once a day; When creatinine concentrations, more than 500 μmol / l are prescribed 5 mg / kg once a day.

Side effect

• anorexia;
• nausea, vomiting;
• heartburn;
• diarrhea;
• dizziness;
• weakness;
• drowsiness;
• violation of color perception;
• fucetitude;
• thrombosis and thromboembolism;
• tachycardia;
• pain in the chest;
• arterial hypotension (with rapid intravenous administration);
• skin rash;
• hives.

Contraindications

• subarachnoid hemorrhage;
• increased sensitivity to the components of the drug.

Application in pregnancy and breastfeeding

It is used in pregnancy according to indications with an obligatory consideration of contraindications, the transcamic acid penetrates through the placental barrier and stands out with breast milk (reaching approximately 1% of the concentration in the plasma of the mother).

special instructions

Before starting and in the treatment process, it is necessary to conduct an inspection of the eyepiece for acuity of vision, color perception, the state of the fundus.

Medicinal interaction

For sharing Thromb formation is possible with hemostatic preparations and hemokoagulase.

A solution for intravenous administration is pharmaceutically incompatible with blood preparations, solutions containing penicillin, urchinase, hypertension (norepinephrine, deoxyepinephrine hydrochloride, metamine batter of), tetracycles, dipyridamol, diazepam.

Caution should be used in combination with heparin and anticoagulants in patients with violations of the coagulation system and at thrombosis (brain vessel thrombosis, myocardial infarction, thrombophlebitis) or the threat of their development.

Analogs of the drug Treexam

Structural analogues for the acting substance:

• Transcamic acid;
• Transamcha;
• Timcasaminate;
• Exacel.

Analogs in the pharmacological group (fibrinolysis inhibitors):

• Amben;
• Aminocaproic acid;
• Aprpecial;
• Apricin;
• AUD;
• Vero Drugp;
• Gordokos;
• Humbix;
• Ingitril;
• Conficilla;
• Pamba;
• Polycapran;
• Trasilol 500000;
• Trasolana.

In the absence of analogues of drugs on the active substance, you can follow the links below on the disease, which helps the appropriate drug, and see the analogues on therapeutic effects.

Structure

active substances: Tranexamic ACID;

1 tablet contains transcamic acid 250 mg

auxiliary substances: kernel - Cellulose microcrystalline, hydroxypropylcellulose, sodium starch (type A), talc, calcium stearate, silicon colloidal dioxide

shell - Hypromellos, titanium dioxide (E 171), Talc, polyethylene glycol 6000.

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Dosage form

Sheath-covered tablets.

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Pharmacological group

Fibrinolysis inhibitors.

PBX code B02A A02.

Indications

Bleeding or risk of bleeding when the fibrinolysis is enhanced as generalized (bleeding during surgery and in the postoperative period on the prostate gland, hemorrhagic complications of fibrinolytic therapy) and local (uterine, gastrointestinal, nose bleed, post-changeable gifema, bleeding after prostatectomy or intervention on the bladder, tonsonyctomectomy, cervical conization, tooth extraction in patients with hemophilia).

Healthy angioedema swelling.

Contraindications

Increased sensitivity to the drug, severe renal failure, macroscopic hematuria, high risk of thrombosis, thrombophlebitis, myocardial infarction, subarachnoid hemorrhage, acute venous or arterial thrombosis; Fibrinolytic states after coagulopathy due to exhaustion, with the exception of excessive activation of the fibrinolytic system during acute severe bleeding convulsions in the history of the violation of the perception of colors.

Method of application and dose

Adult drug is prescribed inside, regardless of meals.

Prostatectomy: For the prevention and treatment of hemorrhage in patients with an increased risk before or after operations, transcamic acid is prescribed in the form of injections, after which it is possible to assign 1 g (2 tablets of 500 mg) in the form of pills 3-4 times a day before the disappearance of macroscopic hematuria.

Menorragia: The recommended dose is 2 tablets 3 times a day, not more than 4 days. With long-term menstrual bleeding dose to increase, but not higher maximum dose (8 tablets per day). It is not necessary to start treating the drug before the start of menstrual bleeding.

Nasal bleeding: With periodic bleeding, appoint 2 tablets 3 times a day for 7 days.

Conization of the cervix Assign 3 tablets 3 times a day until 12 days.

Post traumatic hefhem A 2 tablets 3 times a day.

Extraction of teeth in patients with hemophilia: The recommended dose is 25 mg / kg of transcamic acid inside every 8:00, starting 1 day before the operation and continuing within 2-8 days after it.

Healthy angioedema swelling: Some patients familiar about the progress of the exacerbation of the disease, usually enough 2-3 tablets 2-3 times a day for several days. Other patients should take the drug in the same dose for a long time depending on the course of the disease.

Violation of the excretory function of the kidneys A dose correction is necessary for patients with light and temperate renal failure.

Children: Appoint children over 12 years in a dose of 20-25 mg / kg. The duration of treatment is usually 2-8 days.

Elderly patients In the absence of disorders of the excretory function of the kidneys, the dose correction is not required.

Patients with renal failure It is necessary to adjust the dose according to the plasma creatinine level.

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Adverse reactions

When applying the drug, nausea, vomiting, heartburn, diarrhea, rash may occur, skin itch, reduction of appetite, drowsiness, dizziness. There may be a violation of color; violations; rarely thrombosis, thromboembolism; convulsions possible reactions of hypersensitivity, including anaphylaxis; Arterial hypotension acute necrosis of the crust layer of the kidneys.

Overdose

Symptoms: nausea, vomiting, abdominal pain, orthostatic hypotension, arterial hypotension, dizziness, headache, convulsions or strengthening of the manifestations of other adverse reactions.

Treatment: The use of symptomatic therapy.

Application during pregnancy or breastfeeding

The transcamic acid penetrates through the placenta and in breast milk. Research on the safety of the drug during pregnancy was not carried out, so during this period the drug can be prescribed only when the expected benefit for the mother exceeds the potential risk to the fetus. If necessary, the use of the drug should be resolved by the issue of cessation of breastfeeding.

Children

Do not apply for children under 12 years old.

Features of application

In renal failure (depending on the degree of increasing creatinine serum) reduce the dose and number of administrations. It has been reported in combination due to the formation of a bunch with a source of bleeding in the upper urinary trait In patients receiving a drug. There have been reported on cases of venous and arterial thrombosis or thromboembolism in patients who have taken transcamic acid. In addition, cases of clogging of the central artery of the retina and the central retinal vein were reported. Patients taking the drug for longer than a few days, it is recommended to pass an ophthalmological examination, including testing of visual acuity, the perception of flowers, the eye bottom, of the form.

Patients with thromboembolic disease can be in a higher risk group for venous or arterial thrombosis.

Transcamic acid should not be taken simultaneously with the complex Factor IX or anti-inflexion coagulation complexes, since the risk of thrombosis is increased.

Patients with diffused intravascular coagulation, which requires treatment with transcamic acid, must be under the supervision of a physician who has experience in treating such diseases.

The transkamic acid was detected in sperm in the fibrinolytic concentration, but does not affect the mobility of spermatozoa. Clinical researches did not reveal influence on fertility.

When using transkamic acid, cases reported by the court. Most of these cases have been registered after intravenous application transcamic acid in high doses when carrying out an aortocortonary shunting (AKSH). When using recommended low doses of transkamic acid, the frequency of occurrence of cases by the court after operations is the same as in patients who did not receive transcamic acid.

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The ability to influence the reaction rate when managing vehicles or work with other mechanisms.

During the use of the drug, you should refrain from managing vehicles or working with mechanisms.

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Interaction with other medicines and other types of interactions

The transoxamic acid is incompatible with the urock, norepinephrine of the batter, deoxypnephrine hydrochloride, metarmino batter, dipyridamol, diazepam. Highly active protuberbinity complexes and antifibrinolytic agents, anti-infection coagulation complexes should not be used simultaneously with the transcamic acid. A combination of chlorpromazine and transcamic acid in patients with subarachnoid hemorrhage should be avoided; This can lead to a spasm of cerebral vessels and cerebral ischemia and, possibly, to a decrease in cerebral blood flow symptomatic properties of both drugs, may contribute to the development of spasm of vessels and cerebral ischemia in these patients. With caution, apply a transcamic acid in patients receiving oral contraceptives, as the risk of thrombosis increases.

Pharmacological properties"Type \u003d" Checkbox "\u003e

Pharmacological properties

Pharmacological.

Antifibrinolitic agent. The transcamic acid specifically inhibits the activation of branded and the conversion of fibrinolysin (plasmin). It has a local and systemic hemostatic effect with bleeding, associated with increasing fibrinolysis (platelet pathology, menorgia). Also, transcamic acid through the containment of the formation of kinines and other active peptides involved in allergic and inflammatory reactions has an anti-allergic and anti-inflammatory effect.