Cheap analogues Flemoclav Soluteab: List with reviews and prices

The development of inflammatory processes caused by infection requires treatment with antibiotics. Among the set pharmaceutical preparations This group of specialists allocate Flemoclav Solutab. The medicine has positive feedback, however, it is sometimes necessary to replace the Flemoclav Solutab to analogue.

About preparation

The drug of comprehensive action refers to the group of drugs of antibacterial effects. Flemoclav Soluteab - a potent antibiotic with a Penicillin content.

Active components - amoxicillin trihydrate in conjunction with the addition of clavulanic acid. A drug is realized in the form of tablets (dispersed). Release Flemoclav Soluteab 875 mg, 500 mg, as well as 125 mg.

Indication for drug admission is an infectious damage:

• bronchi and lungs;
• urinary organs;
• otolaryngological tissues;
• sexual sphere;
• skin and soft tissues.

The drug is also prescribed during osteomyelitis, if an infection occurs after the operation and to prevent the pathologies listed.

Contraindications for the appointment of medication:

• renal diseases;
• liver failure;
• mononucleosis;
• lymph leucosis;
• children's age less than 12 years;
• body weight is less than 40 kg;
• intolerance to any components of the composition.

Tablets can cause a number of side effects (you can get acquainted with the list in the instructions), so during pregnancy, it is not recommended to receive on the first trimester, and from the middle of the fetal tool period, medicine can be treated only under the supervision of the attending physician.

The price of the medicine depends on its dosage. The minimum cost is 300 rubles. The medication is included in the list of prescription drugs.

Analogs

In the case when the replacement of the frekdom is required, a specialist receives a decision on a suitable analogue. All drugs of this category refer to the prescription group, so to purchase analogues of Flemoclav Solutab without appointing a doctor in the official pharmacy is impossible.

Given the effectiveness of the original means, the reason for the search for a substitute, most often its cost becomes or side effects. In the presence of contraindications, it is recommended to select an analogue of Flemoclav Soluteab, having the same active substance.

Analogs are cheaper:

• Amoxicillin;
• Panklav;
• Flexin Soluteab;
• Ecoclav;
• Augmentin;
• Amoxiclav.

Before applying any medicine, consult with a specialist.

Amoxiclav.

The amoxiclave drug remedy has a combined effect on the body and is assigned to eliminate infection accompanied by inflammation.

Amoxiclava release form:

• suspension powder;
• oral pills;
• injection powder.

Amoxiclav developed by the Slovenian company. The antibiotic contains a potent component of amoxicillin. To increase the effect of medication to the composition of the acid is added clavulanation.

• for the treatment of diseases of the infectious type of skin arising from the skin and soft tissues, as well as in the bones;
• for complex therapy Diseases internal organs respiratory tract;
• to eliminate otolaryngological, odontogenic and gynecological infectious pathologies;
• with inflammatory processes arising in the gastrointestinal tract and urinary tract.

Injection form of medication is prescribed for the treatment of infection developing in the field abdominal cavity and genital organs. Injection powder is used for prevention before the operation.

Flemkelava substitute is contraindicated in the following health problems:

• a tendency to allergies to the active substance of the composition or additional components;
• infectious form of mononucleosis;
• lympholoicosis.

During therapy, the patient may have symptoms of side effect, which affect many organism systems. Instructions for use describes in detail all possible organism reactions to the medicine. When a negative reaction appears, it is necessary to stop receiving the freclavlav and select a substitute having a different composition.

Amoxiclave is relative inexpensive drug, the price of which is different depending on the shape of the medication.

Average cost:

• tablets - 200 rubles;
• suspension - 100 rubles;
• injection powder - 550 rubles.

Flexin Solutab

Inexpensive analogue of Flemoclav Soluteab 500 mg. - Flexin. The drug is used to prevent the infectious process in the body.

The active ingredient - amoxicillin and acid clavulanation, have an antibiotic effect, preventing the development of an inflammatory infectious process in the tissues of internal organs, joints, muscles and skin.

Flexin SOLUTAB is available only in tablet form. Dispersible tablets have three main types of dosage: 125 mg, 250 mg and 500 mg. Also realizes Flexin solutab 1000 mg.

Indications for use include infections:

• genitourinary;
• respiratory system;
• digestive system;
• muscle tissue;
• surface surfaces.

The maximum price for Flexin Soluteab 1000 mg - 470 rubles, and the minimum - 238 rubles. (125 mg).

Augmentin

Flemcomple - Augmentin substitute is designed to eliminate health problems in the development of infection and subsequent inflammation in the human body. Medicine reviews indicate its high efficiency.

The composition of the drug contains active substances - amoxicillin / clavulanic acid. Unlike the original, the means is produced not only in the form of tablets, but also in the form of a suspension powder.

Augmentin has similar indications, including affecting infections:

• musculoskeletal system;
• surfaces of the dermis;
• soft tissues;
• urinary system;
• respiratory organs;
• oral cavity;
• sex sphere.

Contraindications list:

• allergy to the composition;
• kidney / liver pathology.

Treatment of children and pregnant women is permissible only if the risk is exceeded for life. For three months, the suspension is recommended, over 12 years old - pills. The duration of treatment is determined by an exclusively attending specialist.

The cost of Augmentin is significantly different depending on which the number contains the active substance is amoxicillin.

Augmentin 125 milligram stands cheaper than the original - from 140 rubles.

Amoxicillin

Selecting domestic analogs, it is recommended to pay attention to the original drug having an identical component name - amoxicillin. Unlike other analogues, there is no clavulane acid as part of this medicine.

A low-cost medicine has a list of indications, including an infectious process in organ / system tissues:

• gastrointestinal tract;
• eNT organs;
• urogenital system;
• upper and lower respiratory tract.

The use of a domestic original substitute is not recommended when diagnosing:

• allergic diathesis;
• infectious mononucleosis;
• bronchial asthma;
• respiratory viral infections;
• intolerance by the body of the components of the medication

A cheap analogue of amoxicillin has a minimal price - 28 rubles.

Ekoclav

Another enough enough cheap substitute - Ekoclav. Medicine also applies to antibiotic medication penicillin row.

The activity of the ecoclava is based on the action of amoxicillin substance and clavulane calcium included in the drug in the form of existing components.

Ecoclav is produced by the manufacturer in a standard tableted form with a 27 mg dosage installed. and in the form of a suspension powder with a dose of 125 mg.

Specialists prescribe Ecoclav with pathologies therapy arising against the background of infection, sensitive to the current components, in the respiratory bodies, urinary and its excretory system, sexual sphere and otolaryngology. Also, the medicine is used to treat skin cover, bone-articular and soft tissues.

Before applying, it is necessary to consult with a specialist and determine whether the patient has contraindications that are specified in the instructions.

Side effects, according to reviews, rarely occur and have a weak intensity.

The price of ecoclav in powder is from 150 rubles, and on the tablets - from 250 rubles.

Panklaw.

It is possible to replace the original on Panklav. The medicine is made by the Serbian company and has an average cost - 300 rubles per drug with a dosage of 875 mg. The medication does not apply to cheap analogues, but its price is slightly lower than Flemkelava.

The drug, as well as all listed analogues, has a substance that prevents infectious processes (clavulanic acid and amoxicillin), in the field of genital and urinary organs, oral cavity, respiratory sphere, as well as in diseases of bone, articular and epidermal tissues.

Pancala kids up to 12 years old is contraindicated, during the period of launching a woman of the fetus, during breastfeeding, with infectious mononucleosome And with the intolerance to the composition.

Replace Flemoclav to similar medicinal products You can only with the permission of the doctor. All medicines are antibiotics whose reception should be carried out strictly according to the instructions or directions of the specialist.

Instructions for use Flemoclav Soluteab describes the features of the use of this combined semi-synthetic antibiotic, which is based on two active substances - amoxicillin and clavulanic acid. The predecessor of Flecomclav was the original drug Augmentin, which first appeared in the pharmaceutical market in 1979. It is this means that successfully combined the combination of two actors, gave impetus to the creation of an effective generic - dispersible tablets Flemoclav Soluteab.

Flemoclav Solutab - principle of operation

Popular penicillin antibiotic With a beta-lactamas inhibitor exhibits a wide range of antibacterial action due to the features of its composition. It is known that many bacteria quickly managed to adapt to the chemical formula of benzylpenicillins and learned how to produce special enzymes that destroy the beta-lactam ring. As a result, the use of penicillins could no longer provide the necessary therapeutic effect.

Modern amoxicillin antibiotic is more resistant to the destructive power of pathogenic bacteria, however, it needs a protective component to manifest maximum efficiency. Such a protection and has become clavulanic acid, which is close to penicillin in its structure, but shows a very minor antimicrobial activity.

Nevertheless, due to the structural similarity with the antibiotic molecule and the presence of a beta-lactam ring, clavulanic acid takes "a blow to itself", entering into interaction with the devastating enzymes of bacteria. As a result, the antibiotic amoxicillin receives reliable protection, exhibits increased stability and ability to destroy wide spectrum pathogenic microorganisms.

The principle of operation of the drug is based on the introduction of the active substance into a microbial cell, followed by blocking the synthesis of a particular compound (peptidoglycan) responsible for the construction of cell membranes. As a result of the deficit of this compound, the growth and development of the microbial cell is stopped, and it dies. Bactericidal action Flemoclav Soluteab applies to most of the strains of the pathogenic microflora, including gram-positive and gram-negative anaerobic and aerobic microorganisms.

After taking inside, the active substances are quickly absorbed, penetrate the placental barrier and can be released with breast milk. At the same time, the simultaneous reception of the drug with food does not affect the absorption of the existing components. The medicine is excreted from the body by the kidneys, up to 80% of amoxicillin and up to 50% of clavulanic acid are removed for 6 hours.

Form release

Flemoclav Solutab is produced in the form of large, oblong dispersible white-colored tablets with small brown splashes. The main difference of the medication is that active substances are enclosed in microspheres - special capsules that protect the antibiotic from the aggressive effect of gastric juice and digestive enzymes.

Thanks to this, their release occurs only in the upper department fine intestine and a 12-risk intestine, that is, in that part of the digestive system, where it is possible to fully and quick absorption of the drug. Due to this feature, the dispersible form of the drug is characterized by better portability and safety, eliminates irritation of the intestinal mucosa and provides the most gentle effect.

Good to know

The term "dispersible tablet" means that the drug is rapidly dissolved in a minimum volume of fluid, forming a suspension.

Before taking it into it, it should be homogenized, that is, to stir thoroughly. Thanks to the pleasant apricot taste, the suspension does not cause disgust and, unlike most of the bitter antibiotics, take it much easier.

Flemoclav Soluteab produced in four basic forms:

1. Flemoclav Soluteab 125 mg (125mg + 31.25mg);
2. Flemoclav Soluteab 250 mg (250mg + 62.5 mg);
3. Flemoclav Soluteab 500mg (500mg + 125mg);
4. Flemoclav Soluteab 875 mg (875 + 125mg) - This option is often called Flemoclav Soluteab 1000mg in the amount of the main components.

The first digit indicated in the dosage of the drug means the concentration of amoxicilline antibiotic, the second indicates a dose of clavulanic acid. Accordingly, the lower the concentration of the main active substance, the less the dose of the protective component, which bores the devastating force of bacteria.

Antibiotic tablets 4 pieces are packaged into blisters and placed in cardboard packs, each of which contains 5 blisters. Tablets Flemoclav Soluteab 1000mg are implemented in packs, inside of which there are 2 blisters containing 7 antibiotic tablets.

Indications

Modern antibacterial drug It is used in the treatment of infectious inflammatory diseases caused by microorganisms sensitive to Flemoclav. Prescribe it with the following states:

• eNT infections - organs, upper and lower respiratory tract (otitis, sinusitis, frontitles, sinusitis, tonsillites, pharyngitis, acute and chronic bronchitis, pneumonia, lung abscess, pleural empya);
• infectious processes in the organs of the small pelvis and the urogenital system (urethritis, prostatitis, cystitis, pyelonephritis, salpingitis, endometritis, vaginitis bacterial, complications after abortion, postpartum sepsis, gonorrhea, syphilis);
• infections of soft tissues and skin cover (infected dermatoses, impetigo, row, phlegmon, abscesses, infected wounds);
• infections of joints and bone tissue (osteomyelitis);
• postoperative infections (sepsis).

The drug is often prescribed with dental infections that cause bone tissue destruction (periodontitis) or maxillary hyimorite, which is associated with the infectious process in tissues upper jaw. As prophylaxis, antibiotic is used in surgery, in order to prevent postoperative bacterial complications.

Instructions for use

Dispersible tablets are taken inside, pre-dissolving in 1/3 cup of water and having thoroughly stirring the contents, or ingesting the tablet entirely and drinking sufficient liquid. Take the drug is recommended before meals, as the drug, drunk on an empty stomach, can provoke irritation of the mucosa of the digestive tract.

The dosage of the medication and the duration of the course of treatment determines the doctor taking into account the severity inflammatory process, Type of disease, the general condition of the patient and other nuances. Standard dosages of the drug, according to the instructions, are as follows:

Adult patients and adolescents older than 12 years are prescribed 1 tablet (500mg) every 8 hours, in severe cases, this dose is doubled.

A flopper for children is used in a smaller dosage. The daily dose of the drug is calculated by the doctor, taking into account the mass of the body's body. Typically, for kids aged from 3 months before 2 years, 1 tablet is prescribed (125 mg). Multiplicity of reception - twice a day. From three to seven years, the dosage of the drug is the same, but the multiplicity of reception is increased to three times a day. Children from 7 to 12 years old dose double, that is, they give 1 tablet (250 mg) every 8 hours.

The duration of treatment depends on the severity of the disease, an average course of therapy with an antibiotic takes from 10 to 14 days.

Contraindications

Flemoclav Soluteab exhibits less toxicity in comparison with other antibacterial agents, however, there are a number of pathologies that exclude the use of this drug. Antibiotic is contraindicated in the following states:

• hypersensitivity to the components of the drug or individual intolerance to the beta-lactam antibiotics of the penicillin or cephalosporin row;
• lympholoikosis.

Tablets Flemoclav Soluteab 1000mg can not be used in the treatment of children under 12 years of age and with a body weight less than 40kg. In addition, this form of the drug cannot be prescribed when renal failureIf the speed of glomerular filtration is less than 30 ml / min.

With extreme caution and under the control of the drug, the drug is prescribed with severe hepatic and chronic renal failure, pathologies of the digestive system, including colitis developed against the background of the use of penicillins.

Adverse reactions

Like any antibiotic, Flemoclav Solutab is able to call adverse reactions From various systems of the body. Most often, such manifestations are marked by the digestive system. Tablets can provoke flatulence, abdominal pain, nausea, vomiting, diarrhea. Much less often arise symptoms of bowel candidiasis, colitis (hemorrhagic, pseudomembranous) or staining of the upper layer of dental enamel.

Not uncommon and allergic reactions that are accompanied by a rash, urticaria, itching. With long-term reception, a corppy examine may develop, drug fever, serum disease or bullous dermatitis. The most severe manifestations are anaphylactic shock, laryngeal edema or quinque swelling are manifested in exceptional cases. At the first signs of an allergic reaction, the reception should be discontinued and apply for medical help. The patient may need the introduction of adrenaline or prednisone and carrying out measures to restore respiratory functions.

Much less often meet the following side effects:

1. From the cardiovascular and nervous system - Vasculitis, dizziness, migraine, insomnia, increased anxiety, aggressiveness, hyperactivity, change in consciousness.
2. From blood formation organs - thrombocytosis, hemolytic anemia, leukopenia, granulocyptopenia, thrombocytopenia, increased bleeding. But these violations quickly disappear after the cancellation of the drug.
3. The liver has an increase in the activity of hepatic enzymes, in rare cases - manifestations of cholestatic jaundice or hepatitis. Greeting system - itching, burning, discharge from the vagina, symptoms of jade (interstitial).
4. In very rare cases against the background of long-term treatment of the drug or repeated courses, antibiotic develop bacterial or fungal superinfections.

Flemoclav Solutab during pregnancy

Despite the fact that active substances easily penetrate the placental barrier, clinical researches did not reveal the teratogenic effect of the drug on the fruit and the emergence of congenital abnormalities of development in a newborn baby. However, in the first trimester of pregnancy, Flemoclav Soluteab should be appointed only after evaluating the potential risk for the fetus. During this period, the drug is prescribed with caution, such a form, as a tablet Flemoclav 1000mg is prohibited for use. Only those forms of the drug can be used, in which the active ingredient is represented in smaller concentrations.

With breastfeeding, both active substances penetrate the maternal milk in fairly large volumes, but the baby is not harmful. Therefore, you can not translate the child to artificial mixtures in the process of treating the mother by this antibiotic. But if the newborn manifests the reactions of increased sensitivity - diarrhea, candidiasis of mucous membranes, breast-feeding We'll have to stop for a while.

Special care requires the use of the drug in patients with severe disorders of the liver functions. In this case, the dosage of the antibiotic is reduced and regular laboratory control and monitoring of the patient's condition.

Good to know

A weighted approach requires the purpose of the drug in individuals with severe forms of bronchial asthma or allergies, especially in cases where the allergic reactions occur earlier on the use of antibiotics from a group of penicillins or cephalosporins.

Flemoclav Solutab should not be prescribed simultaneously with disulfiramas, aminoglycosides, laxatives, since the absorption of active substances decreases. Do not combine the reception of antibiotic and indirect coagulants, since such a tactic increases the risk of bleeding.

Analogs

The structural analogues of Flemoclav Soluteab include the following drugs:

• Augmentin;
• Bortoklav;
• Liklav;
• Panklav;
• Tomerentine;
• Fibell.

The decision to replace the antibiotic with similar means should receive only the attending physician.

Price

The cost of the drug depends on the form of the release and concentration of active substances in tablets. Average prices for Flemoclav Soluteab in pharmacies:

• Tablets 125mg (20pcs) - from 290 rubles;
• Tablets 250 mg (20pcs) - from 400 rubles;
• 500mg tablets (20pcs) - from 380 rubles;
• Tablets 875 mg (14pcs) - from 370 rubles.

For children, one of the suspensions will fit well:

Price

The average price is online *, 421 r. (Table 500mg + 125mg)

Where can one buy:

Instructions for use

Flemoclav Solutab - a wide spectrum antibiotic. It is used to treat children and adults, including can be used by women in the period breastfeeding.

Indications

The drug is intended for the treatment of infectious and inflammatory diseases caused by sensitive microorganisms:

• diseases of the upper respiratory tract and LOR organs (sinusitis, tonsillitis, pharyngitis, middle otita, etc.);
• skin and soft tissue infections;
• diseases of the lower respiratory tract (COPD, complete Pneumonia, exacerbations chronic bronchitis and etc.);
• infections of the urinary system (pyelonephritis, cystitis, etc.).

Tablets 875 mg + 125 mg are also prescribed in obstetrics, gynecology and for the treatment of infections of bones with joints (osteomyelitis, etc.).

Method of application and dose

The medicine is taken inward before meals - it helps prevent the appearance of dyspeptic disorders. Tablets swallowed entirely, not chewing and drinking water. Another option is to dissolve the tablet in 30 ml of water, stir and drink. The maximum duration of reception of the means is 14 days, but on the recommendation of the doctor the course of treatment can be extended.

Adults, children from 12 years old and more younger children with weight from 40 kg take 500 mg + 125 mg 3 times a day or 875 mg + 125 mg 2 times a day.

Tablets drink through the same time intervals. Doses sometimes double, if the patient is severe, chronic or recurrent infection.

Children under 12 years of age with weight of less than 40 kg take the drug in smaller doses: 125 mg + 31.25 mg; 250 mg + 62.5 mg or 500 mg + 125 mg.

Children at the age of 2-7 years with a weight of 13-25 kg are prescribed 125 mg + 31.25 mg 3 times a day, children 7-12 years old with weight of up to 37 kg - 250 mg + 62.5 mg. If the infection is severe, the daily dose can be doubled.

Renal failure

Due to the slow down removal of amoxicillin and clavulanic acid kidneys, the drug in the dosage of 875 mg + 125 mg is prescribed, provided that the glomeric filtering comes at a speed above 30 ml / min.

The total dose of the drug, expressed in the amount of amoxicillin, should not be higher than the values \u200b\u200bspecified in the table:

Peat pathology

The drug is prescribed with caution. During the treatment period, it is necessary to constantly monitor the liver function.

Contraindications

Absolute contraindications:

• intolerance of the components of the drug;
• intolerance to other beta-lactam antibiotics (penicillins and cephalosporins);
• lympholoicosis;
• infectious mononucleosis;
• having previously transferred yellow or liver dysfunction against the background of amoxicillin intake and clavulanic acid.

Tablets 875 mg + 125 mg can also be taken to children under 12 years of age with weight of less than 40 kg and patients with renal failure, in which glomerular filtration rate is 30 ml / min. and less.

Relative contraindications:

• severe kidney failure;
• gCC diseases (including previously transferred colitis caused by the treatment of penicillins);
• chronic insufficiency kidney.

Pregnancy and lactation

Treatment with the drug during lactation is allowed. If the child appears diarrhea, sensitization or candidiasis of mucous membranes, the mother will have to stop breastfeeding until the end of treatment.

Overdose

If these symptoms appear, the victim should take activated coal. It also shows symptomatic treatment.

Side effects

Tablets 125 mg + 31.25 mg; 250 mg + 62.5 mg; 500 mg + 125 mg can provoke a number of negative reactions:

• hardwriter and an examination;
• diarrhea;
• nausea with vomit;
• liver disorders;
• vasculitis;
• changes in blood;
• cholestatic jaundice;
• hepatitis;
• interstitial nephritis;
• the development of superinfection;
• anaphylactic shock (single cases).

When taking a tablet 875 mg + 125 mg possible:

• allergic reactions;
• the development of superinfection;
• thrombocytosis and hemolytic anemia;
• headache and dizziness;
• convulsions;
• abdominal pain;
• nausea with vomiting;
• diarrhea;
• flatulence;
• a slight increase in the activity of hepatic enzymes;
• cholestatic jaundice;
• hepatitis.

Structure

Active substances - amoxicillin (125; 250; 500 or 875 mg) and clavulanic acid (31.25; 62.5 or 125 mg).

Auxiliary components: Crospovidon, Vanillin, Mcz, Apricot Spandy, magnesium stearate, Sakharin.

Pharmacology and pharmacokinetics

Flemoclav Solutab - a wide spectrum antibiotic. It oppresses the synthesis of the bacterial wall.

The medicine is actively in terms of gram-negative and gram-positive microorganisms, including strains that produce beta lactamases.

Clawulanic acid is characterized by high tropiness to penicillins.

Therefore, it forms a stable complex with an enzyme and does not allow the enzymatic degradation of amoxicillin under the influence of beta-lactamas. As a result, the spectrum of its action is expanding.

Shelf life

3 years (2 years for tablets in the dosage of 875 mg + 125 mg).

Name:

Flemoclav Solutab (Flemoclav Solutab)

Pharmachologic effect:

Flemoclav Solutab - an antibiotic of a wide range of action, active in terms of gram-positive and gram-negative microorganisms, including bacteria that produce beta lactamases. Amoxicillin in combination with clavulanic acid has a significantly large spectrum of action than with monotherapy.

Amoxicillin is a beta-lactam antibiotic group of penicillins. Amoxicillin disrupts the integrity of the cell membrane of bacteria, as a result of which the death of microorganism comes. Amoxicillin is inactivated by beta lactamases, so under monotherapy is inactive with respect to strains producing beta lactamases.

Clawulanic acid - has a minor antimicrobial effect. Clawulanic acid is inactivating staphylococcal beta lactamases and gram-negative bacteria.

Flemoklav Soljutab effective against Streptococcus faecalis, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis, Moraxella catarrhalis, Haemophilus influenzae, Proteus mirabilis, and Bacteroides fragilis, Neisseria gonorrhoeae, Neisseria meningitidis, Klebsiella spp., Escherichia coli, Salmonella spp., Shigella spp .

Absolute bioavailability of amoxicillin with oral use Depends on the dose and is about 72-94%, clavulanic acid - about 60%. The peak of the plasma concentration of amoxicillin and clavulanic acid is achieved within 1-2 hours. Meal does not affect the absorption speed and the bioavailability of the drug Flemoclav Soluteab.

Amoxicillin is excreted mainly by the kidneys, the half-life is about 1-1.5 hours, in patients with kidney dysfunction, the half-life of amoxicillin increases. Amoxicillin penetrates the hematoplazent barrier and is determined in breast milk.

Indications for use:

Flemoclav Soluteab is designed for the treatment of patients with infectious diseases of various localization and severity, which are caused by a sensitive to the combination of amoxicillin and a microflorine clavulanic acid.

In particular, Flemoclav Soluteab is prescribed in otolaryngological practice and in infectious diseases of the skin, soft tissues, respiratory tract and organs of the urinary tract.

Flemoclav Solutab can also be appointed with sepsis, osteomyelitis, peritonitis and postoperative infections.

Application technique:

Flemoclav Soluteab is designed for oral administration. The dispersed pills should be swallowed or chew or chew, drinking with a small amount of drinking water. In addition, tablets can be taken, having previously dissolved in half a glass of drinking water. To reduce the risk of developing undesirable effects on the part of the digestive tract, the drug should be taken immediately before meals. To achieve maxima therapeutic effect Tablets are recommended to receive at regular intervals. Therapy with the drug should be continued for at least 3 days after the disappearance of the symptoms of the disease. In case of infections caused by hemolytic streptococcus the duration of therapy should be at least 10 days.

The duration of reception and dose of the drug Flemoclav determines the attending physician.

Adults and teenagers with a mass mass of more than 40kg, as a rule, are prescribed 500 mg of the drug three times a day. In chronic, recurrent infections, as well as severe forms of dose disease, it is possible to increase to 875-1000 mg of amoxicillin three times a day.

Children with body weight from 13 to 37kg, as a rule, prescribe 20-30 mg / kg body weight per day. Daily dose should be divided into three receptions. In chronic, recurrent infections, as well as severe forms of diseases, the dose can be increased to 60 mg / kg body weight per day.

Elderly patients with normal kidney function Correction of the dose of the drug Flemoclav is not required.

Patients with kidney dysfunction Dose of amoxicillin and clavulanic acid are calculated depending on the clearance of creatinine.

Adults with clearance of creatinine from 10 to 30 ml / min, as a rule, 500 mg of amoxicillin are prescribed twice a day.

Adults with creatinine clearance less than 10 ml / min, as a rule, are prescribed 500 mg of amoxicillin per day.

Children with clearance of creatinine from 10 to 30 ml / min, as a rule, amoxicillin is prescribed at a dose of 15 mg / kg body weight twice per day.

Children with clearance of creatinine less than 10 ml / min, as a rule, amoxicillin is prescribed at a dose of 15 mg / kg body weight per day.

Unwanted phenomena:

During the period of amoxicillin and clavulanic acid treatment, such unwanted phenomena is possible:

From the hepatobiliary system and the gastrointestinal tract: pain and discomfort in the stomach, nausea, flatulence, vomiting, diarrhea, duspection, color change of dental enamel, dry mouth mucous membrane, change in taste sensations and raising the level of hepatic enzymes. In some cases, the development of pseudommabranous colitis, hemorrhagic colitis, intestinal candidiasis, hepatitis (including with cholestasis) and severe liver function disorders.

From the vessels, hearts and blood formation systems: hemolytic anemia, thrombocytosis, granulocyptopenia, leukopenia, thrombocytopenia, pancytopenia, anemia and myelosuppression. In addition, there was an increase in the time of bleeding and the development of vasculitis.

From the central nervous system: cramps, headache, dizziness, unfortunately, increased fatigue, aggression.

Allergic reactions: Urticaria, Exanthema, skin itch, Stevens-Johnson Syndrome, Exudative Multiform Erythema, Toxic Epidermal Necrolizes, Acute Generalized Exandtematous Pustulaz and Sweet Sweep. In isolated cases, the development of anaphylactic shock (including with deaths), in this case, adrenaline is prescribed, parenteral glucocorticosteroids and conduct therapy of respiratory failure.

Others: superinfection, vaginal candidiasis, vaginitis, interstitial jade, crystalluria.

Contraindications:

Flemoclav is not prescribed to patients with individual amoxicillin intolerance, clavulanic acid and beta-lactam antibiotics (including penicillins and cephalosporins).

Flemoclav should not use patients who have noted the development of liver function disorders at the previous reception of clavulanic acid or amoxicillin, as well as patients with diseases of the digestive tract, which are accompanied by chronic diarrhea and vomiting.

Flemoclav is contraindicated in infectious mononucleosis and lymphole.

Special caution should be taken, prescribing the drug Flemoclav patients with a tendency to develop anaphylactoid reactions, bronchial asthma and impairment of liver and kidney functions.

Patients who lead a car or control potentially unsafe mechanisms should respect special caution during the treatment period of Flemoclav.

During pregnancy:

Amoxicillin and clavulanic acid do not have a negative impact on the development of the fetus. The combination of amoxicillin and clavulanic acid can be assigned during pregnancy after a thorough risk assessment and benefit. In the first trimester of pregnancy, it is recommended to use more secure alternative means.

If you avoid the reception of the drug, Flemoclav during the lactation period is impossible, it is recommended to resolve the issue of temporary interruption of breastfeeding.

Interaction with other drugs:

During the treatment period, Flemoclav is not recommended to be prescribed chemotherapeutic drugs and antibiotics with bacteriostatic effects (with compulsive use, the efficiency of amoxicillin is reduced).

The effectiveness of amoxicillin may increase with compigenous use with cephalosporins, rifampicin, vancomycin and cycloserine.

The combined use of amoxicillin with disulfiram is prohibited.

There is an increase in the level of plasma concentrations of amoxicillin when combined with a probenecide, oxyphenbutasone, butadion, indomethacin, sulfintizon and acetylsalicylic acid.

Risk of skin development increases allergic reactions With the combined application of the drug, Flemoclav with Allopurinol.

Amoxicillin reduces the plasma concentrations of sulfasalazine and increases plasma concentrations and toxicity of methotrexate during combined use.

Flemoclav with simultaneous use can increase the absorption of digoxin.

The risk of bleeding is increasing with the combined use of kumarine anticoagulants and the drug Flemoclav.

The combination of amoxicillin and clavulanic acid can lead to a decrease in the effectiveness of estrogen-containing oral contraceptives and a change in certain results of laboratory studies.

Ascorbic acid increases the absorption of amoxicillin, and the laxatives, glucosamine, antacid substances and aminoglycosides reduce the absorption of amoxicillin in the intestine.

Overdose:

When using overpriced doses of amoxicillin and clavulanic acid, patients increase the risk of developing and the severity of undesirable effects.

In case of overdose of the drug, Flemoclav is possible to develop disorders from the digestive tract, disorders of the water and electrolyte balance and seizures.

With severe intoxication, amoxicillin in patients note disorders of consciousness, muscle cramps, hemolytic reactions, acidosis and renal failure, as well as shock conditions and crystallurium.

No specific antidote. When taking high doses of the drug, Flemoclav is shown to wash the stomach, the reception of enterosorbent drugs and osmotic laxatives. Overdose should be monitored water-electrolyte balance And blood pH.

During the development of seizures, they are prescribed diazepam. In severe renal failure, hemodialysis should be conducted.

Development of a shock state requires immediate resuscitation activities.

In order to reduce the plasma concentration of amoxicillin, the forced diuresis is also shown.

The form of the drug:

Dispersed tablets, containing 125, 250 or 50 mg of amoxicillin, packaged 5 pieces into contour cellular packages, in a carton 4 contour cellular packaging.

Dispersed tablets containing 875 mg amoxicillin, packaged 5 or 7 pieces into contour cellular packages, in a carton 2 contour cellular packaging.

Storage conditions:

Flemoclav is stored no more than 3 years from the date of manufacture in rooms at a temperature not higher than 25 ° C.

It is allowed to appear on the surface of the marble tablets and small points of brown during storage.

Synonyms:

Amoxiclav, Augmentin, Medoclaw.

Structure:

1 Tablet of the drug Flemoclav 125 + 31.25 contains:

Amoxicillin - 125 mg,

Acid Clawulanova - 31.25 mg,

1 Tablet of the drug Flemoclav 250 + 62.5 contains:

Amoxicillin - 250 mg,

Acid Clavulanova - 62.5 mg,

Additional substances, including vanillin and Sakharin.

1 Tablet of the drug Flemoclav 500 + 125 contains:

Amoxicillin - 500 mg,

Additional substances, including vanillin and Sakharin.

1 Tablet of the drug Flemoclav 875 + 125 comprises:

Amoxicillin - 875 mg,

Acid Clawulanova - 125 mg,

Additional substances, including vanillin and Sakharin.

Preparations of similar action:

Medoclav (MEDOCLAV) Bicyllin-3 (Bicillinum-III) Amoxyl (Amoxil) clonacom (clonacom-x) clonacom-p (clonacom-p)

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The page provides instructions for use. Flemclav Solyutab. It is produced in various dosage forms The drug (125 mg tablets, 250 mg, 500 mg, 875 mg and 1000 mg dispersible), and also has a number of analogues. This abstract is checked by specialists. Leave your feedback on the use of Solutab Flemkelva, which will help other site visitors. The drug is used for various diseases (angina, bronchitis, sinusitis, otitis and others infectious diseases). The tool has a number of side effects and features of interaction with other substances. Doses of the drug differ for adults and in children. There are restrictions on the use of medication during pregnancy and during breastfeeding. Treatment of Flemoclav Solyutab can be appointed only by a qualified physician. The duration of therapy may vary and depends on the specific disease.

Instructions for use and dosage

Adults and children over 12 years old and children under 12 years old with a body weight of more than 40 kg Flemoclav Soluteab in a dose of 875 mg / 125 mg are prescribed 2 times a day (every 12 hours).

Children under 12 years old with a body weight of less than 40 kg are prescribed Flemoclav Soluteab in smaller dosages.

Adults and children with a body weight of more than 40 kg are prescribed 500 mg / 125 mg 3 times a day. With severe, chronic, recurrent infections, this dose can be doubled.

The daily dose for children is usually 20-30 mg of amoxicillin and 5-7.5 mg of clavulanic acid per kg of body weight. Possible dosing mode for children, depending on the age and mass of the child's body:

• age from 3 months to 2 years - body weight from 5 to 12 kg - daily dose Tablets 125 mg / 31.25 mg 2 times a day;
• age from 2 to 7 years old - body weight from 13 to 25 kg - daily dose of tablet 125 mg / 31.25 mg 3 times a day;
• age from 7 to 12 years - body weight from 25 to 37 kg - daily dose of tablet 250 mg / 62.5 mg 3 times a day.

For heavy infections These doses can be doubled (the maximum daily dose is 60 mg of amoxicillin and 15 mg of clavulanic acid per kg of body weight).

The duration of treatment depends on the severity of the infection and without necessity should not exceed 14 days.

To prevent the appearance of side effects from the digestive system, the drug is recommended to be taken at the beginning of meals. The tablet swallows entirely by drinking a glass of water, or dissolve it in half a glass of water (minimum 30 ml), having thoroughly stirring before use (the suspension is obtained, convenient for receiving children).

Forms of release

Tablets dispersible 125 mg, 250 mg, 500 mg, 625mg, 875 mg and 1000 mg.

Other forms of release, be something syrup, injections in ampoules or capsules do not exist.

Structure

Amoxicillin trihydrate (amoxicillin) + potassium clavulanate (clavulanic acid) + excipients.

Flemoclav Soluteab - antibiotic of a wide range of action; combined drug Amoxicillin and clavulanic acid - beta-lactamase inhibitor. Active in terms of gram-positive and gram-negative microorganisms (including strains producing beta-lactamases).

Amoxicillin acts bactericity, inhibits the synthesis of peptidoglycan of the cell wall of bacteria. Clawulanic acid inhibits beta lactamases 2, 3, 4 and 5 types. Not active in relation to beta lactamases type 1 produced by Enterobacter SPP., Pseudomonas Aeruginosa, Serratia SPP., Acinetobacter SPP. Clawulanic acid has high tropiness to penicillinases, therefore it forms a stable complex with an enzyme, which prevents the enzymatic degradation of amoxicillin under the influence of beta-lactamas and expands the spectrum of its action.

Flemoclav Soluteab is active with respect to aerobic and anaerobic gram-positive bacteria, aerobic and anaerobic gram-negative bacteria.

Pharmacokinetics

Amoxicillin

After taking inside, it is quickly absorbed from the gastrointestinal tract. Amoxicillin absorption during oral administration is 90-94%. Simultaneous meal does not affect absorption. Amoxicillin penetrates through the placental barrier and in small quantities stands out with breast milk. Approximately 60-80% of amoxicillin is excreted through the kidneys during the first 6 hours after receiving the drug.

Clawulanic acid

After taking inside, it is quickly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 60%. Simultaneous meal does not affect absorption. Bonding with serum proteins is 22%. Clawulanic acid penetrates a placental barrier. There are no reliable data on isolation with breast milk. Clawulanic acid is subjected to intensive metabolism by hydrolysis and subsequent decarboxylation. Approximately 30-50% of clavulanic acid is excreted through the kidneys during the first 6 hours after taking the drug.

Indications

• bacterial infections caused by sensitive pathogens: infections of the lower respiratory tract (bronchitis (acute and aggravation of chronic), pneumonia, empty of pleura, lung abscess);
• eNT infections (sinusitis, angina, tonsillitis, average otitis);
• infections of the urogenital system and small pelvis organs (pyelonephritis, pyelitis, cystitis, urethritis, prostatitis, cervicitis, salpingitis, salpingoophoritis, tubarial abscess, endometritis, bacterial vaginitis, septic abortion, postpartum sepsis, pelvioperitonitis, soft chance, gonorrhea);
• infections of the skin and soft tissues (row, impetigo, secondary infected dermatoses, abscess, phlegmon, wound infection);
• osteomyelitis;
• postoperative infections;
• prevention of infections in surgery.

Contraindications

• violation of the liver function (including jaundice) when taking amoxicillin / clavulanic acid in history;
• infectious mononucleosis;
• lympholoicosis;
• renal failure (glomeric filtering less than 30 ml / min) - for tablets of 875 mg / 125 mg dispersible;
• children under 12 years old with a body weight of less than 40 kg (for pills dispersible 875 mg / 125 mg);
• increased sensitivity to amoxicillin, clavulanic acid and other components of the drug;
• increased sensitivity to other beta-lactam antibiotics (penicillins and cephalosporins).

special instructions

When taking Flemclav Solutab, there is the possibility of cross-stability and increased sensitivity with other penicillins or cephalosporins.

In the case of the development of anaphylactic reactions, the drug should be immediately discontinued and carried out appropriate therapy: for the treatment of anaphylactic shock, urgent introduction of epinephrine (adrenaline), glucocorticosteroids (GKS) and elimination of respiratory failure may be required.

It is possible to develop superinfection (for example, candidiasis), especially in patients with chronic diseases and / or violations of the function immune system. In the event of superinfection, the reception of the drug is canceled and / or appropriately change the antibacterial therapy.

Patients with severe gastrointestinal disorders, accompanied by vomiting and / or diarrhea, the purpose of Flemkelava Solyutab is impractical until the above symptoms are eliminated, because Perhaps a violation of the absorption of the drug from the gastrointestinal tract.

The appearance of a severe and rack diarrhea may be due to the development of pseudommabranous colitis, in this case the drug is canceled and assigned necessary treatment. In the case of the development of hemorrhagic colitis, immediate abolition of the drug and corrective therapy are also necessary. The use of drugs weakening intestinal peristalsis in these cases is contraindicated.

In disruption of the liver function, the drug should be prescribed with caution and under constant medical supervision. It should not be applied to the drug over 14 days without estimating the liver function.

In a single study, the prophylactic reception of amoxicillin / clavulanate in women with a premature gap of the fruit shells increased the risk of developing necrotic enterocolitis in newborns.

Against the background of taking the drug, an increase in prothrombin time can be noted. Therefore, Flemoclav Solutab should be prescribed with caution to patients receiving anticoagulant therapy (it is necessary to monitor blood coagulation indicators).

In connection with high concentration Amoxicillin in the urine, it may be precipitated on the walls of the blade, so such patients need a periodic change of catheters. Forced diuresis accelerates the removal of amoxicillin and reduces its plasma concentration.

During the application of Flemkelava Soluteab, the non-enzyme methods for determining glucose in the urine, as well as a urobilinogen test can give false positive results.

During course treatment, it is necessary to control the functions of the blood formation organs, liver and kidneys.

If convulsion appears against the background of therapy, the drug is canceled.

It should be borne in mind that in 1 tablet dispersible 875 mg / 125 mg contains 25 mg of potassium.

Side effect

• thrombocytosis, hemolytic anemia, leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia;
• an increase in prothrombin time and bleeding time;
• dizziness;
• headache;
• convulsions;
• anxiety;
• anxiety;
• insomnia;
• violation of consciousness;
• aggressive behavior;
• vasculitis;
• abdominal pain;
• nausea, vomiting;
• flatulence;
• diarrhea;
• pseudomambranous colitis (in the case of severe and rack diarrhea on the background of drug intake or within 5 weeks after completion of therapy);
• candidiasis of the intestine;
• hemorrhagic colitis;
• cholestatic jaundice;
• itching, burning and discharge from the vagina;
• interstitial nephritis;
• skin rash and itching;
• corppy Exanthema;
• hives;
• bullous or exfoliative dermatitis (multiform exudative erythema, Stevens-Johnson syndrome, toxic epidermal necroliz);
• anaphylactic shock;
• drug Fever;
• eosinophilia;
• angioedema edema (swelling of quinque);
• highland swelling;
• serum disease;
• hemolytic anemia;
• allergic vasculitis;
• bacterial or fungal superinfection (with long therapy or re-courses of therapy).

Medicinal interaction

With simultaneous use with some bacteriostatic preparations (for example, chloramphenicol, sulfonamides), antagonism with amoxicillin / clavulanic acid was noted.

Flemoclav Solutab should not be appointed simultaneously with disulfram.

Simultaneous reception of amoxicillin renal excretion of amoxicillin (samples, phenylbutazone, oxyphenbutayone and, at least acetylsalicylic acid, indomethacin and sulfinpyrazone), helps to increase concentration and longer finding amoxicillin in blood plasma and bile. The excretion of clavulanic acid is not disturbed.

With simultaneous anti-salty antiqisid, glucosamine, laxative preparations, aminoglycosides slow down and reduce amoxicillin absorption, ascorbic acid increases amoxicillin absorption.

The simultaneous use of Soluteab Fleomeclava with Allopurinol can increase the risk of developing skin rash.

Ethanol (alcohol) reduces the absorption rate of amoxicillin in the gastrointestinal tract.

Aminopenicillins can reduce the concentration of sulfasalazine in serum.

Amoxicillin reduces the kidney clearance of methotrexate, which can lead to an increase in its risk toxic action. With simultaneous reception with amoxicillin, monitoring of methotrexate in serum is necessary.

The simultaneous use of amoxicillin / clavulanic acid and digoxin can lead to an increase in digoxin absorption.

With the simultaneous use of Flemkelava Soluteab and indirect anticoagulants, it is possible to increase the risk of bleeding.

In rare cases, against the background of amoxicillin intake, a decrease in the effectiveness of oral contraceptives was noted, so the patient should recommend the use of non-correlative methods of contraception.

Analogs medicinal preparation Flemoclav Soluteab

Structural analogues for the acting substance:

• AmoVikom;
• Amoxiclav;
• Amoxiclav Kviktab;
• Amoxicillin + clavulanic acid pfeiser;
• Artilet;
• Augmentin;
• Bortoklav;
• Verklav;
• Clamor;
• Liklav;
• Medoclav;
• Panklav;
• Ranxlav;
• Rapiklav;
• Tomerentine;
• Fibell;
• Ekoclav.

Application in pregnancy and breastfeeding

When using Flemkelava Soluteab during pregnancy, it was not marked negative influence on the fruit or newborn. The use of the drug in 2 and 3 trimester of pregnancy is possible after a medical risk / benefit assessment. In 1 trimester of pregnancy, SOLUTAB FLEEKOLAVA use should be avoided (only for tablets dispersible 875 mg / 125 mg). Pills dispersible 125 mg / 31.25 mg, 250 mg / 62.5 mg, 500 mg / 125 mg in 1 trimester of pregnancy must be appointed with caution.

Amoxicillin and clavulanic acid penetrate the hematoplazent barrier and stand out with breast milk. It is possible to use the drug during breastfeeding period.

In the case of the development of sensitization, diarrhea or candidiasis of mucous membranes, breastfeeding should be stopped.