INSTRUCTION

for medical use of the drug

Registration number LSR-004228 / 09-280509

Tradename: Furazolidone

International non-proprietary name:

Furazolidone

Dosage form:

pills

Composition:

1 tablet contains:
Active substance- furazolidone - 0.05 g
Excipients- potato starch - 0.02 g

calcium stearate (calcium stearic acid) - 0.001 g

sugar (sucrose) - 0.01 g

tween-80 (polysorbate) -0.0002 g

lactose (milk sugar) - 0.0188 g Description:
Tablets are yellow or greenish-yellow, flat-cylindrical with a bevel.

Pharmacotherapeutic group:

Antimicrobial and antiprotozoal agent.

ATX code: G01AX06

Pharmacodynamics
Antimicrobial agent derived from nitrofurans. Active against gram-positive and gram-negative microbes, Trichomonas spp., Ciardia lamblia. The most sensitive to furazolidone are Shigella dysenteria spp., Shigella flexneri spp., Shigella boydii spp., Shigella sonnei spp .. Salmonella typhi, Salmonella paratyphi. Weakly affects the causative agents of purulent and anaerobic infections. Resistance of microorganisms develops slowly. Blocks monoamine oxidase.
Nitrofurans disrupt the processes of cellular respiration of microorganisms, suppress the tricarboxylic acid cycle (Krebs cycle), and also inhibit the biosynthesis of nucleic acids in microorganisms, resulting in the destruction of their membrane or cytoplasmic membrane. As a result of the action of nitrofurans, microorganisms secrete less toxins, and therefore an improvement general condition the patient is possible even before the pronounced suppression of the growth of microflora. Unlike many other antimicrobial drugs, they not only do not inhibit, but even activate immune system organism (increase the titer of complement and the ability of leukocytes to phagocytose microorganisms).

Pharmacokinetics
Well absorbed when oral administration... Against the background of inflammation meninges in the cerebrospinal fluid, concentrations equal to those in plasma are created. It is rapidly and extensively metabolized mainly in the liver with the formation of a pharmacologically inactive metabolite (amino derivative). It is excreted mainly by the kidneys (65%), small amounts are found in feces, where therapeutic concentrations are achieved against pathogens of intestinal infections

Indications for use

Dysentery, paratyphoid fever, giardiasis, foodborne diseases.

Contraindications

Pregnancy, lactation. Individual hypersensitivity to the nitrofuran group. Terminal stage of chronic renal failure, deficiency of glucose-6-dehydrogenase, childhood up to 3 years (for this dosage form).
Carefully

Chronic renal failure, glucose-6-phosphate dehydrogenase deficiency, liver disease and nervous system.

Method of administration and dosage

Inside, after eating. With dysentery, paratyphoid fever and food toxicoinfections - 100-150 mg 4 times a day (but not more than 800 mg), for 5-10 days.
With giardiasis: adults - 100 mg 4 times a day, children - 10 mg / kg / day, distributing the daily dose for 3-4 doses. The highest single dose for adults - 200 mg; daily - 800 mg.

Side effect

Decreased appetite, up to anorexia; nausea, vomiting; allergic reactions(skin rash, flushing and itching of the skin, angioedema). At long-term use- neuritis.

Overdose (intoxication) with the drug

Symptoms: acute toxic hepatitis, hematotoxicity, neurotoxicity (polyneuritis). Treatment: cancellation of drugs, intake of large amounts of fluids, symptomatic therapy, antihistamines, B vitamins.

Interaction with other medicinal products

Furazolidone in combination with ethanol can lead to the development of disulfiram-like reactions, and therefore, their simultaneous use is not recommended.
Antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, phenylephrine, tyramine can cause a sharp increase in blood pressure.

special instructions

Increases inhibition of hematopoiesis against the background of chloramphenicol and ristomycin. Increases sensitivity to the action of ethanol. Medicines that alkalinize urine reduce the effect, while those that acidify increase it.
Aminoglycosides and tetracycline enhance antimicrobial properties.
In the course of treatment, precautions should be followed, as with the use of monoamine oxidase inhibitors, namely: excluding foods containing tyramine from the diet: cheese, cream, beans, pickled herring, strong coffee. For the prevention of neuritis with prolonged use, it is necessary to combine with vitamins of group B.

Furazolidone- antibacterial medicine... The pharmacological action of the drug directly depends on the dose, when using low doses, furazolidone has a bacteriostatic effect, with an increase in the dose, a pronounced bactericidal activity is noted. In addition, the drug has some immunostimulating effect. The mechanism of the antimicrobial action of the drug lies in the ability of the nitro group of furazolidone under the action of bacterial enzymes to be restored to the amino group. Substances formed as a result of the reduction of the nitro group have a toxic effect, block a number of biochemical processes in the bacterial cell, disrupt the structure and integrity of the cell membrane. In particular, when using furazolidone, there is an irreversible blockade of NADH and inhibition of the tricarboxylic acid cycle, as a result of which cellular respiration of microorganisms, the function of the cytoplasmic membrane is disrupted and the death of the microorganism occurs. The furazolidone molecule, due to its ability to form complex compounds with nucleic acids, disrupts the synthesis of a number of proteins in the bacterial cell, as a result of which the growth and reproduction of microorganisms is inhibited.
The mechanism of the drug's immunostimulating action lies in its ability to increase the titer of complement and the phagocytic activity of leukocytes. In addition, furazolidone reduces the production of toxins by microorganisms, as a result of which an improvement in the general clinical picture is noted earlier than microbiological tests give a negative result.
The ability of furazolidone to inhibit monoamine oxidase was noted, which leads to the development of mild arousal in patients taking this drug... Furazolidone increases the body's sensitivity to ethyl alcohol, which can lead to the development of nausea and vomiting with the simultaneous use of alcohol and furazolidone.
The drug is effective in the treatment of infectious diseases caused by strains of microorganisms sensitive to the action of furazolidone, including:
Gram-positive and gram-negative aerobic bacteria: Streptococcus spp., Staphylococcus spp., Shigella spp. (Including Shigella dysenteria, Shigella boydii, Shigella sonnei), Salmonella typhi, Salmonella paratyphi, Esherichia coli, Proteus spp. ...
The drug is also effective against protozoa, including Trichomonas spp., Lamblia spp.
In addition, the drug is effective against fungi of the genus Candida, however, sensitivity tests should be performed before the appointment of furazolidone for the treatment of candidiasis.
Microorganisms, pathogens of anaerobic and purulent infections, are practically insensitive to furazolidone.

Indications for use

A drug Furazolidone used to treat patients with infectious diseases organs gastrointestinal tract, genitourinary system, as well as skin, in particular: bacillary dysentery, typhoid, paratyphoid fever, enterocolitis, giardiasis, diarrhea infectious etiology, food poisoning, Trichomonas infection, including Trichomonas colpitis, as well as vaginitis, urethritis, cystitis and pyelitis, patients with infected wounds and burns.

Mode of application

A drug Furazolidone taken orally. It is recommended to swallow the tablet whole, without chewing or crushing, drinking plenty of water. The drug should be taken after meals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient, depending on the nature of the disease and the personal characteristics of the patient.
For the treatment of dysentery, paratyphoid fever and foodborne diseases, adults are usually prescribed 0.1-0.15 g (2-3 tablets) of the drug 4 times a day. The duration of the course of treatment, depending on the severity of the disease, is from 5 to 10 days. The drug can also be taken in cycles of 0.1-0.15 g 4 times a day for 3-6 days, after which they take a break for 3-4 days and resume taking the drug according to the same scheme.
Adults for the treatment of giardiasis are usually prescribed 0.1 g (2 tablets) of the drug 4 times a day.
Adults for the treatment of Trichomonas urethritis are usually prescribed 0.1 g (2 tablets) of the drug 4 times a day. The duration of the course of treatment is 3 days.
For the treatment of Trichomonas colpitis, adults are usually prescribed 0.1 g (2 tablets) of the drug 3-4 times a day orally in combination with drugs containing furazolidone, in the form of vaginal and rectal suppositories... The duration of the general course of treatment is 1-2 weeks, the duration of oral administration of the drug in complex therapy is 3 days.
The maximum single dose for adults is 0.2 g of the drug (4 tablets), the daily dose is 0.8 g (16 tablets).
For children for the treatment of dysentery, paratyphoid fever and foodborne toxicoinfections, the dose is determined depending on age and body weight. The maximum duration of the course of treatment is 10 days.
For the treatment of giardiasis, children are usually prescribed a drug at 10 mg / kg of body weight per day. The daily dose should be divided into 3-4 doses.
For the treatment of infected wounds and burns, the drug is prescribed in the form of irrigation or wet-drying dressings, having previously prepared a solution of furazolidone with a concentration of 1: 25000.

Side effects

A drug Furazolidone low toxicity, however, in some cases, side effects may develop during therapy with furazolidone, including:
From the gastrointestinal tract: anorexia, nausea, vomiting, pain in the epigastric region.
Allergic reactions: skin rash, itching, urticaria, Quincke's edema.
To reduce the severity of side effects, it is recommended to drink the drug with plenty of water, as well as take B vitamins and antihistamines. With pronounced side effects, the drug should be discontinued and consult your doctor.
With prolonged use of the drug, hemolytic anemia and methemoglobinemia may develop (mainly in newborns and infants), as well as shortness of breath, cough, hyperthermia and neurotoxic reactions.

Contraindications

Contraindications to the use of the drug Furazolidone are: increased individual sensitivity to the components of the drug; contraindicated in patients with end-stage chronic renal failure; for the treatment of children under the age of 1 month; patients with glucose-6-phosphate dehydrogenase deficiency and lactase deficiency; pregnancy and lactation, as well as in patients with impaired renal function; patients suffering from diseases of the liver and nervous system; patients whose work is related to driving and potentially dangerous machinery.

Pregnancy

A drug Furazolidone during pregnancy should be taken strictly as directed by the attending physician, who must carefully weigh the expected benefits to the mother and the potential risks to the fetus.
If it is necessary to use the drug during lactation, the issue of a possible interruption should be resolved. breastfeeding, since furazolidone penetrates into breast milk and can cause the development of hemolytic anemia and methemoglobinemia in infants.

Interaction with other medicinal products

With the simultaneous use of the drug Furazolidone with drugs that change the pH of urine, there is a change in the rate of excretion of furazolidone. So drugs that change the pH of urine to the alkaline side, increase the excretion of furazolid and reduce its effectiveness, and drugs that change the pH of urine to the acidic side, reduce the rate of excretion of furazolidone and increase it pharmachologic effect... With the simultaneous use of aminoglycosides and tetracycline, they enhance the pharmacological effects of furazolidone. With the combined use of the drug with chloramphenicol and ristomycin, the inhibition of hematopoiesis increases. With the simultaneous use of furazolidone with ethyl alcohol the development of disulfiram-like reactions is noted. The drug is not prescribed concurrently with antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, tyramine and phenylephrine due to the risk of hypertensive reactions.

Overdose

In case of drug overdose Furazolidone patients may develop toxic liver damage, including acute toxic hepatitis. In addition, the development of polyneuritis (neuro toxic effect) and the hematotoxic effect of furazolidone. There is no specific antidote. In case of an overdose of the drug, gastric lavage, the intake of enterosorbents and saline laxatives are indicated. If necessary, measures are taken to maintain the water and electrolyte balance. It is also possible to prescribe antihistamines and B vitamins.

Storage conditions

A drug Furazolidone it is recommended to store in a dry place away from direct sunlight at a temperature not exceeding 25 degrees Celsius. Shelf life is 3 years.

Release form

Tablets of 10 pieces in a contoured cell-free package.
Tablets of 10 pieces in a blister, 2 blisters in a cardboard box.

Composition

1 tablet Furazolidone contains: Furazolidone - 0.05 g;
Excipients, including lactose.

main parameters

Name:	FURAZOLIDONE
ATX code:	G01AX06 -

Furazolidone (Furazolidonum)

Composition

1 tablet contains:
Furazolidone - 0.05 g;
Excipients, including lactose.

pharmachologic effect

Furazolidone is an antibacterial drug of the nitrofuran group. Furazolidone, a synthetic derivative of 5-nitrofurfural, which has a pronounced antimicrobial activity against gram-negative aerobic microorganisms, is less sensitive to the action of the drug, gram-positive aerobic microorganisms, some protozoa and fungi (in particular, fungi of the genus Candida). The pharmacological action of the drug directly depends on the dose, with the use of low doses, furazolidone has a bacteriostatic effect, with an increase in the dose, a pronounced bactericidal activity is noted. In addition, the drug has some immunostimulating effect. The mechanism of the antimicrobial action of the drug lies in the ability of the nitro group of furazolidone under the action of bacterial enzymes to be restored to the amino group. Substances formed as a result of the reduction of the nitro group have a toxic effect, block a number of biochemical processes in the bacterial cell, and disrupt the structure and integrity of the cell membrane. In particular, when using furazolidone, an irreversible blockade of NADH and inhibition of the tricarboxylic acid cycle are noted, as a result of which cellular respiration of microorganisms, the function of the cytoplasmic membrane is disrupted and the death of the microorganism occurs. The furazolidone molecule, due to its ability to form complex compounds with nucleic acids, disrupts the synthesis of a number of proteins in the bacterial cell, as a result of which the growth and reproduction of microorganisms is inhibited.

The mechanism of the drug's immunostimulating action lies in its ability to increase the complement titer and the phagocytic activity of leukocytes. In addition, furazolidone reduces the production of toxins by microorganisms, as a result of which an improvement in the general clinical picture is noted earlier than microbiological tests give a negative result.
The ability of furazolidone to inhibit monoamine oxidase was noted, which leads to the development of mild arousal in patients taking this drug. Furazolidone increases the body's sensitivity to ethyl alcohol, which can lead to the development of nausea and vomiting with the simultaneous use of alcohol and furazolidone.
The drug is effective in the treatment of infectious diseases caused by strains of microorganisms sensitive to the action of furazolidone, including:
Gram-positive and gram-negative aerobic bacteria: Streptococcus spp., Staphylococcus spp., Shigella spp. (Including Shigella dysenteria, Shigella boydii, Shigella sonnei), Salmonella typhi, Salmonella paratyphi, Esherichia coli, Proteus spp. ...
The drug is also effective against protozoa, including Trichomonas spp., Lamblia spp.
In addition, the drug is effective against fungi of the genus Candida, however, sensitivity tests should be performed before the appointment of furazolidone for the treatment of candidiasis.
Microorganisms, pathogens of anaerobic and purulent infections, are practically insensitive to furazolidone.

Drug resistance develops slowly.
After oral administration, the drug is rapidly absorbed in the gastrointestinal tract. In blood plasma, therapeutically significant concentrations of the drug are observed within 4-6 hours after oral administration. In patients with meningitis, the concentrations of furazolidone in the cerebrospinal fluid correspond to those in the blood plasma. After absorption, the drug is rapidly metabolized in the body, mainly in the liver, with the formation of a pharmacologically inactive metabolite. Due to the rapid metabolism of the drug, there are no therapeutically significant concentrations of furazolidone in the blood and tissues (including the kidneys). It is excreted mainly by the kidneys, both unchanged and in the form of a pharmacologically inactive metabolite. High therapeutic concentrations of the drug are noted in the intestinal lumen.
In patients suffering from renal failure, there is an accumulation of the drug in the body due to a decrease in the rate of its excretion by the kidneys.

Indications for use

The drug is used to treat patients with infectious diseases of the gastrointestinal tract, genitourinary system, and skin, in particular:
Bacillary dysentery, typhoid, paratyphoid fever, enterocolitis, giardiasis, diarrhea of ​​infectious etiology. The drug is also used to treat food poisoning.
Trichomonas infection, including Trichomonas colpitis, as well as vaginitis, urethritis, cystitis, and pyelitis.
The drug is used to treat patients with infected wounds and burns.

Mode of application

The drug is taken orally. It is recommended to swallow the tablet whole, without chewing or crushing, drinking plenty of water. The drug should be taken after meals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient, depending on the nature of the disease and the personal characteristics of the patient.
For the treatment of dysentery, paratyphoid fever and foodborne diseases, adults are usually prescribed 0.1-0.15 g (2-3 tablets) of the drug 4 times a day. The duration of the course of treatment, depending on the severity of the disease, is from 5 to 10 days. The drug can also be taken in cycles of 0.1-0.15 g 4 times a day for 3-6 days, after which they take a break for 3-4 days and resume taking the drug in the same way.
Adults for the treatment of giardiasis are usually prescribed 0.1 g (2 tablets) of the drug 4 times a day.
Adults for the treatment of Trichomonas urethritis are usually prescribed 0.1 g (2 tablets) of the drug 4 times a day. The duration of the course of treatment is 3 days.

For the treatment of Trichomonas colpitis, adults are usually prescribed 0.1 g (2 tablets) of the drug 3-4 times a day orally in combination with drugs containing furazolidone in the form of vaginal and rectal suppositories. The duration of the general course of treatment is 1-2 weeks, the duration of oral administration of the drug in complex therapy is 3 days.
The maximum single dose for adults is 0.2 g of the drug (4 tablets), the daily dose is 0.8 g (16 tablets).
For children for the treatment of dysentery, paratyphoid fever and foodborne toxicoinfections, the dose is determined depending on age and body weight. The maximum duration of the course of treatment is 10 days.
For the treatment of giardiasis, children are usually prescribed a drug at 10 mg / kg of body weight per day. The daily dose should be divided into 3-4 doses.
For the treatment of infected wounds and burns, the drug is prescribed in the form of irrigation or wet-drying dressings, having previously prepared a solution of furazolidone with a concentration of 1: 25000.

Side effects

The drug is low-toxic, however, in some cases, side effects may develop during therapy with furazolidone, including:
From the gastrointestinal tract: anorexia, nausea, vomiting, pain in the epigastric region.
Allergic reactions: skin rash, itching, urticaria, Quincke's edema.
To reduce the severity of side effects, it is recommended to drink the drug with plenty of water, as well as take B vitamins and antihistamines. With pronounced side effects, the drug should be discontinued and consult your doctor.
With prolonged use of the drug, hemolytic anemia and methemoglobinemia may develop (mainly in newborns and infants), as well as shortness of breath, cough, hyperthermia and neurotoxic reactions.

Contraindications

Increased individual sensitivity to the components of the drug.
The drug is contraindicated in patients with end-stage chronic renal failure.
The drug is not used to treat children under the age of 1 month.
Due to the fact that the drug contains milk sugar (lactose), it should not be prescribed to patients with glucose-6-phosphate dehydrogenase deficiency and lactase deficiency.
The drug should be used with caution in women during pregnancy and lactation, as well as in patients with impaired renal function.
The drug is prescribed with caution to patients suffering from diseases of the liver and nervous system.
The drug should not be prescribed to patients whose work is associated with driving and potentially dangerous machinery.

Pregnancy

The drug during pregnancy should be taken strictly as directed by the attending physician, who must carefully weigh the expected benefits to the mother and the potential risks to the fetus.
If it is necessary to use the drug during lactation, the question of a possible interruption of breastfeeding should be resolved, since furazolidone penetrates into breast milk and can cause hemolytic anemia and methemoglobinemia in infants.

Drug interactions

With the simultaneous use of the drug with drugs that change the pH of urine, there is a change in the rate of excretion of furazolidone. So drugs that change the pH of urine to the alkaline side, increase the excretion of furazolid and reduce its effectiveness, and drugs that change the pH of urine to the acidic side, reduce the rate of excretion of furazolidone and enhance its pharmacological action.
With the simultaneous use of aminoglycosides and tetracycline, they enhance the pharmacological effects of furazolidone.
With the combined use of the drug with chloramphenicol and ristomycin, the inhibition of hematopoiesis increases.
With the simultaneous use of furazolidone with ethyl alcohol, the development of disulfiram-like reactions is noted.
The drug is not prescribed concurrently with antidepressants, monoamine oxidase inhibitors, ephedrine, amphetamine, tyramine and phenylephrine due to the risk of hypertensive reactions.

Overdose

When using overestimated doses of the drug in patients, the development of toxic liver damage, including acute toxic hepatitis, is possible. In addition, the development of polyneuritis (neurotoxic effect) and hematotoxic action of furazolidone is possible.
There is no specific antidote. In case of an overdose of the drug, gastric lavage, the intake of enterosorbents and saline laxatives are indicated. If necessary, measures are taken to maintain the water and electrolyte balance. It is also possible to prescribe antihistamines and B vitamins.
In the case of a severe overdose of the drug, as well as when using excessive doses of the drug in patients with impaired renal function, hemodialysis is indicated.

Release form

Tablets of 10 pieces in a contoured cell-free package.
Tablets of 10 pieces in a blister, 2 blisters in a cardboard box. Attention!
Description of the drug " Furazolidone"on this page is a simplified and expanded version of official instructions by application. Before purchasing or using the drug, you should consult with your doctor and familiarize yourself with the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the doses and methods of its use.

Furazolidone is a drug used for protozoal invasion of the gastrointestinal tract and skin, as well as for infections urinary tract bacterial etiology.

The advantages of the agent are the low risk of developing resistance of pathogenic microorganisms, which allows for use in case of repeated infections. It is possible to use furazolidone both as part of a complex antibiotic therapy regimen and in monotherapy.

Furazolidone - instructions for use for children and adults

In the course of laboratory tests, the antimicrobial activity of the antibiotic was established against gram-negative shigella and salmonella, some types of gram-positive strains of bacteria (staphylococcus), as well as chlamydia and lamblia. However, it does not show sufficient effectiveness in the treatment of mixed infection caused by several types of pathogens. Thus, its appointment for complicated infectious diseases is not advisable.

It should be noted that the antimicrobial activity of furazolidone excludes the possibility of its use for rotavirus infection. The remedy is only effective against bacterial infections or the simplest. This fact due to its mechanism of anti-infective activity. The mechanism of action consists in disrupting the processes of cellular respiration of bacteria or protozoa by inhibiting the cascade of biochemical reactions in the Krebs cycle (synthesis of tricarboxylic acid). As a result, damage to the cell wall or cytoplasmic membrane occurs, which leads to the active influx of molecules from the environment into the cell, which leads to its swelling and death.

Is Furazolidone an antibiotic or not?

Yes this medication- antibiotic, active substance furazolidone belongs to the derivatives of nitrofuran, a synthetic class of antibacterial agents.

It should be noted that nitrofurans are characterized by a high frequency of adverse reactions with an incorrect dosing regimen, therefore, only the attending physician can prescribe a treatment regimen and dosage after collecting a complete medical history. Self-correction of the duration of treatment and the prescribed dosages is unacceptable.

Pharmacological group

Antibacterial agents (nitrofuran derivatives).

The tool has high efficiency when administered orally. It is characterized by a short half-life, which does not exceed 2 hours. The main part (up to 95%) of the active ingredient is metabolized and only 5% accumulates in the urine. It is noted that in case of kidney pathologies, the elimination of the drug takes much more time.

Along with antimicrobial activity, it exhibits an immunostimulating effect, activating the work of leukocytes, cells responsible for phagocytosis - absorption and digestion of foreign agents.

Furazolidone composition

The composition of 1 tablet contains 50 mg of the main active ingredient - furazolidone.

Additionally, lactose is indicated in the composition of the product.

Release form

Furazolidone for children is available in the form of granules in glass jars with a measuring cup, packed in cardboard boxes with instructions.

For adults, the medicine is available in tablet form, 10 pieces in a foil contour plate. Number of plates: from 2 to 5 in a cardboard box with recommendations for use.

The third form of release is in plastic jars of 50 tablets each.

It should be noted that, regardless of the form of release, the concentration of the active substance is 50 mg per 1 tablet.

Latin recipe

The tablets and granules are available over the counter with a prescription just like any other antibiotic. On the prescription, certified by the doctor's personal seal, the full name is indicated. the patient and the name of the active ingredient.

Rp .: Furazolidone 50 mg

What is furazolidone used for?

The medicine is prescribed for infectious lesions of the gastrointestinal tract by sensitive types of microorganisms.

According to statistics, according to official data, more than 90 million cases of dysentery infection with Shigella bacteria are recorded annually, 700 thousand of which end in death. Therefore, at the first signs of illness: fever, stomach pain, frequent stools (up to 20 times a day) mixed with pus and mucus, you should immediately consult a doctor. When confirming the shigelous etiology of OCI, furazolidone is often prescribed as part of complex therapy.

The use is also justified for paratyphoid infections - caused by bacteria of the genus Salmonella. Important: regardless of age, if paratyphoid is suspected and diagnosed, the patient must be hospitalized. Treatment is carried out under the supervision of a doctor around the clock.

Furazolidone is no less effective for bacterial cystitis, as well as in the treatment of urethritis, or vaginal mucous epithelium. This fact is due to the sensitivity of bacteria of the Enterobacteriaceae family to furazolidone.

The doctor prescribes furazolidone for diarrhea, which may be the result of bacterial or protozoal invasion of the human body.

Furazolidone - indications for use

Indications for the appointment of the antibiotic furazolidone are diagnosed forms of infectious lesions of the gastrointestinal tract or urinary system. List of diseases:

• paratyphoid;
• dysentery;
• urethritis;
• giardiasis.

In view of the growth of bacterial resistance to antibiotics, furazolidone for cystitis should be prescribed only after receiving crops for sensitivity.

Contraindications

The appointment of an antibiotic is unacceptable in case of individual intolerance to the active substance or antibiotics of the nitrofuran group. The minimum age for therapy is 1 month, however, for children under the age of 8, treatment should be carried out under the continuous supervision of a physician.

Furazolidone is contraindicated during pregnancy and breastfeeding, as well as with severe pathology kidneys. It is taken with caution in case of disorders of the central nervous system, mental disorders and with dysfunction of the enzymatic system.

Dosage and method of application of furazolidone

How to take: after meals, drink plenty of boiled water... Chewing tablets is not allowed.

The calculation of the dosage of furazolidone for children is made strictly by the attending physician, taking into account the age and weight of the child.

For patients from 1 to 8 years old, the permissible dose should not exceed 0.15 g, and the maximum duration of treatment is 10 days. It is also necessary to take three-day breaks after 3-4 days of admission.

The formula for calculating the dosage for children over 8 years old: 5 mg per 1 kg. Important: daily dose divided into 4 steps.

Dosing regimen for adults with acute intestinal infections: 1-3 tablets 3-4 times a day. The frequency of admission is determined by the doctor depending on the severity of the disease and the patient's condition. The duration of the course should not exceed 10 days.

For the treatment of giardiasis and urethritis, 2 tablets are used 4 times a day.

Important: the maximum allowable daily dose is 800 mg.

Such a large number of tablets per day is due to the rapid period of absorption and half-life of the active ingredient from the human body.

Side effects of furazolidone

It is noted that with a correctly selected dose and frequency of administration, the frequency of adverse reactions is minimal. The severity of negative symptoms depends on the patient's degree of sensitivity to the active ingredient. List of possible reactions of the body:

• digestive upset: nausea, vomiting, decreased appetite and abdominal pain:
• immediate allergic reactions: skin redness, itching.

When the first signs of intolerance appear, it is necessary to cancel its use, and also consult a doctor to correct the antibiotic therapy regimen and symptomatic treatment.

Furazolidone during pregnancy and breastfeeding

It is not recommended to use furazolidone during pregnancy. The medicine is prescribed only if it is impossible to select an alternative treatment for an infection that poses a real threat to the life of the mother and child.

In view of the ability of the active ingredient to penetrate into breast milk and negatively affect the formation of the normal symbiotic microflora of the child, if necessary, prescribe a medicine, breastfeeding should be stopped. Resumption of lactation is possible after the complete removal of the antibacterial agent from the mother's body (at least 1 day after cancellation).

Furazolidone and alcohol - compatibility and consequences

The combined use of antibiotics and alcoholic beverages is strictly prohibited. The consequences of drinking alcohol and furazolidone are disulfame-like reactions. As a result, the patient often has a high fever, headaches, a sharp drop in blood pressure, increased heart rate, nausea and vomiting, seizures, and panic attacks.

Moreover, alcohol and antibiotic compete and are metabolized by similar groups of enzymes. As a result, their incomplete decomposition is noted, which leads to acute intoxication organism. The sick person's condition deteriorates significantly, and the treatment is ineffective.

Furazolidone analogs

Currently, there are no complete or partial analogs in chemical composition.

What is better furazolidone or enterofuril?

The main active ingredient of enterofuril is nifuroxazide, which is an antibacterial agent with a wide range of sensitive microorganisms. The minimum age limit is 3 years. In view of the fact that one of the auxiliary components is fructose, the drug is contraindicated for people with intolerance and diabetes mellitus.

A distinctive advantage of enterofuril is the possibility of therapy during breastfeeding after consulting a doctor.

The price of enterofuril is much higher and is 350 rubles for the capsule form, 400 rubles for the suspension. Therefore, in the absence of contraindications for the appointment of furazolidone, it is the preferred form.

In addition, furazolidone is used for cystitis, urethritis, dysentery and paratyphoid fever, in turn, the only indication for the appointment of enterofuril is diarrhea of ​​bacterial etiology.

Do you know what the drug "Furazolidone" is? Why are these pills prescribed by doctors and how to take them? We will answer these and other questions in the materials of this article.

Release form of the medicinal product, its composition

About what helps "Furazolidone", we will tell below.

According to the instructions, the said agent is made in the form of tablets. Their main component is furazolidone. Also medicinal product contains an excipient such as lactose.

In what packaging is the drug "Furazolidone" sold? Instructions for use (analogues of this product are listed below) of these tablets are contained in a cardboard box. As for the drug itself, it is packaged in cell or non-cell packaging.

Mechanism of action

What does Furazolidone help from? According to the instructions, this antibacterial drug... Its pharmacological action directly depends on the prescribed dosage. When using a small amount of furazolidone, the drug exhibits a bacteriostatic effect. If the dosage of the drug is increased, then it has a pronounced bactericidal effect.

Speaking about the drug "Furazolidone" (from which these tablets, we learn below), one cannot but say that this drug is characterized by some immunostimulating effect.

The antimicrobial effect of the drug in question is explained by the ability of its nitro groups to be restored to the amino group. This happens under the action of bacterial enzymes.

The components that were formed during the reduction of the nitro group have a toxic effect. In addition, they block a number of biological and chemical processes in bacterial cells, and also disrupt the integrity and structure of their shell.

When using furazolidone, blockade (irreversible) of NADH is observed, as well as inhibition of the tricarboxylic acid cycle. This effect contributes to the disruption of the cellular respiration of microorganisms, the work of the cytoplasmic membrane, as a result of which the death of harmful microorganisms occurs.

Features of the tool

Due to the ability of the furazolidone molecule to form complex compounds with nucleic acids, the agent in question disrupts the synthesis of proteins in bacterial cells, which inhibits the reproduction and growth of harmful microorganisms.

What does Furazolidone help from? This remedy works well with lowered immunity. Such properties of the drug are associated with its ability to increase the activity (phagocytic) and the titer of leukocyte complement. In addition, the main substance of this agent reduces the production of toxins by bacteria, as a result of which the total clinical picture improves much earlier than microbiological tests show a negative result.

Properties of the drug

What properties are characteristic of the drug "Furazolidone"? What does this remedy help with? It has been proven by specialists that furazolidone is capable of inhibiting monoamine oxidase. This feature of the medication leads to the development of mild arousal in patients.

It should also be said that this drug increases the body's sensitivity to ethanol. This can lead to the development of vomiting and excessive nausea with the joint use of medication and alcoholic beverages.

So what does Furazolidone help from? This drug is highly effective in the treatment of infectious diseases that are caused by strains of bacteria that are sensitive to the influence of furazolidone. In addition, the said agent works well against protozoa and candidal fungi. However, it should be noted that sensitivity tests must be performed before prescribing this medication.

According to the doctors, the medication in question has practically no effect on the causative agents of anaerobic and purulent infections.

The drug "Furazolidone": what helps?

Tablets with this name are often used to treat people with infectious diseases in the genitourinary sphere. In addition, they are very effective in the presence of diseases of the gastrointestinal tract and skin.

Answering the question about what "Furazolidone" treats, we can safely list the following conditions: typhus, bacillary dysentery, food poisoning, paratyphoid fever, diarrhea of ​​infectious origin, vaginitis, enterocolitis, urethritis, giardiasis, Trichomonas infection, Trichomonas colpitis, cystitis, infected wounds and burns, pyelitis.

Prohibitions on taking the drug

Are there any contraindications for Furazolidone tablets (this remedy helps against cystitis very well)? According to the instructions, the medication in question cannot be used when:

• lactase deficiency and lack of glucose-6-phosphate dehydrogenase;
• hypersensitivity (individual) to the components of the medication;
• chronic renal failure (including;
• under the age of one month;
• breastfeeding;
• impaired kidney function;
• pregnancy;
• diseases of the liver and NS;
• driving and working with dangerous machinery.

Instructions for the use of tablets "Furazolidone"

The medication in question helps with diarrhea very well. This is due to the fact that it is able to inhibit the growth and reproduction of bacteria that contribute to the development of dysbiosis.

This drug is taken by mouth. The tablet must be swallowed whole, without crushing and chewing, but only with a large amount of liquid.

The drug should be taken only after a meal. The duration of treatment with them, as well as the dosage of the drug, is determined by the treating doctor individually for each patient (depending on the nature of the disease and the individual characteristics of the person).

Will "Furazolidone" help with rumbling in the stomach? Of course it will help. For the treatment of foodborne diseases, paratyphoid fever and dysentery, adult patients are prescribed 2-3 tablets of the drug four times a day. The duration of the course depends on the severity of the disease and is approximately 5-10 days.

The medication in question can be used in cycles. In this case, it is prescribed at 0.1-0.15 g four times a day for 3-6 days, after which they take a short break of 3-4 days. Further, taking the medication is resumed in the same way.

For this drug is prescribed (for adults) 0.1 g four times a day.

For therapy, 2 tablets of the drug are used with the same frequency. The duration of the course in this case is 3 days.

For treatment, adult patients are recommended to take 0.1 g of the medication three times a day. For the best therapeutic effect the drug in question is combined with drugs that also contain furazolidone, but only in the form of rectal and vaginal suppositories. The duration of the general course of therapy with this drug is 1-2 weeks. In this case, the duration of oral administration of the drug should not exceed three days.

The maximum dosage (single) for adults is 0.2 g, and the daily dosage is 0.8 g.

For babies for the treatment of paratyphoid fever and dysentery, the dose of this agent is determined depending on body weight and age. The maximum duration of therapy in this case is 10 days.

For the treatment of giardiasis, children are usually prescribed 10 mg / kg of the drug per day. It is advisable to divide the above amount of medication into 4 doses.

For the treatment of infected burns and wounds, the drug is recommended to be used in the form of wet-drying gauze dressings or irrigation. To do this, you must first prepare a solution of furazolidone, the concentration of which will be 1: 25000.

Side actions

According to the instructions, the agent in question is low toxic. Although in some cases, against the background of its reception, such side effects, how:

• anorexia, skin rash, nausea, urticaria;
• vomiting, itching, epigastric pain, Quincke's edema.

In order to reduce the severity of such phenomena, the drug is recommended to be taken with a large amount of liquid. You should also use antihistamines and B vitamins.

In case of severe adverse reactions, taking the medication should be discontinued, after which you will immediately contact your doctor.

With prolonged use of the medication, the patient may develop hemolytic anemia and methemoglobinemia (mainly in newborns and infants). In addition, the drug in question is characterized by such adverse reactions like shortness of breath, cough, hyperthermia and neurotoxic effects.

Pill overdose

In case of an overdose of this agent, people experience toxic liver damage, including acute.Polyneuritis and the hematotoxic effect of the active substance may also develop.

Drug interaction

When the drug "Furazolidone" is taken together with agents that change the pH of urine, a change in the rate of excretion of its active substance is observed.

With the simultaneous use of tetracycline and aminoglycosides increase pharmacological effects furazolidone, and when combined with "Ristomycin" and "Chloramphenicol", the process of hematopoiesis is inhibited.

When taking furazolidone with alcohol, disulfiram-like reactions develop.

The drug in question is not prescribed in conjunction with antidepressants, ephedrine, monoamine oxidase inhibitors, tyramine, amphetamine and phenylephrine. This is associated with the risk of developing hypertensive effects.

Analogs and reviews

The drug in question can be replaced by such means as Betadine, Lactozhinal, Hexicon, Chlorhexidine, Hyposol, Trichomonacid, Dafnedzhin, Macmiror, Depantol, Iodoxide, Iodovidone ".