The drug Polyoxidonium is an effective and high-quality immune stimulant, the main purpose of which, based on pharmacological action, is to raise the level of immunity.

This drug greatly increases the degree of resistance of an adult, as well as a child's body to various infections, successfully copes with the consequences of immunodeficiency.

In this article, we will look at why doctors prescribe Polyoxidonium, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Polyoxidonium can be read in the comments.

Composition and form of release

Tablets are flat-cylindrical, each of them has a chamfer. Their color can vary from yellowish-white to orange-yellow. In tablets, the presence of slightly noticeable particles of a more intense color is allowed.

The composition of one tablet of Polyoxidonium includes 12 mg active ingredient, as well as potato starch (Amylum solani), lactose monohydrate (Lactose monohydrate), stearic acid (Acidum stearicum) as auxiliary components.

Clinical and pharmacological group: immunostimulating drug.

What helps Polyoxidonium?

In adults and children over 6 years of age complex therapy for the correction of immune deficiency:

• to activate regenerative processes (fractures, burns, trophic ulcers);
• for the rehabilitation of often and long-term (more than 4-5 times a year) sick people;
• during and after chemotherapy radiotherapy tumors;
• various forms of tuberculosis;
• complicated by recurrent bacterial and viral infection allergic diseases(including hay fever, bronchial asthma, atopic dermatitis);
• rheumatoid arthritis, long-term treated with immunosuppressants; with complicated acute respiratory infections or acute respiratory viral infections during rheumatoid arthritis;
• chronic recurrent inflammatory diseases of any etiology, not amenable to standard therapy, both in the acute stage and in remission;
• acute and chronic viral and bacterial infections, including urethritis, cystitis, pyelonephritis in the latent stage and in the acute stage, prostatitis, chronic salpingo-oophoritis, endometritis, colpitis, diseases caused by the papillomavirus, cervical ectopia, dysplasia, leukoplakia;
• to reduce the nephro- and hepatotoxic effects of drugs.

As monotherapy:

• for the prevention of recurrent herpetic infection;
• for the correction of secondary immunodeficiencies arising from aging or exposure to adverse factors;
• for seasonal prevention of exacerbations of chronic foci of infections, including in the elderly;
• for the prevention of influenza and acute respiratory infections.

pharmachologic effect

Polyoxidonium is an agent with immunomodulatory and detoxifying properties. Increases the body's resistance to various infectious diseases.

It is able to normalize the immune status in severe forms of immunodeficiency, including secondary immunodeficiency, due to damage by ionizing radiation, in the treatment of hormones and cytostatics, after operations, severe injuries, burns and malignant tumors.

Reduces the toxicity of drugs and various toxic substances, increasing resistance cell membranes to the cytotoxic effect of these substances.

Instructions for use

According to the instructions for use, Polyoxidonium tablets can be swallowed without chewing, after which they can be washed down with plenty of water without gas, preferably 30 minutes before meals, and you can eat 1 hour after ingestion.

• Prevention of acute respiratory viral infections in frequently ill patients - 2 tablets 2 times / day - 10-15 days.
• Chronic diseases of the upper and lower respiratory tract- 2 tablets (24 mg) 2 times / day for 10-14 days.
• Prevention of respiratory diseases (influenza, SARS) during the epidemic period - 2 tablets 2 times / day from 10 to 15 days.
• Viral, fungal, bacterial diseases that are difficult to treat - 1 tablet 2 / day for 15 days.
• Frequent exacerbations chronic diseases affecting the nose, ear and throat - 1 tablet 2 times / day for 10 days.
• Maintenance therapy for tuberculosis, oncological diseases, immunodeficiency - 1 tablet 2 times / day for up to 12 months.

The duration of administration and dose of the drug in some cases can be changed after the conclusions of the doctors treating the patient, which will necessarily take into account the patient's age, the presence of concomitant diseases, the severity of their course, the state of immunity.

Contraindications

This drug is contraindicated for use for people with hypersensitivity to the components that make up its composition. The use of Polyoxidonium is not recommended for women during pregnancy and lactation, with kidney failure and age up to 6 months are sufficient factors to prohibit the use of this drug.

Side effects

The main side effect of the use of suppositories and tablets can be considered hypersensitivity reactions. In some patients with intramuscular application medication, there is soreness at the injection site and redness. After the first few injections of the drug, an increase in body temperature may be observed.

Analogues

The analogues of Polyoxidonium in terms of the mechanism of action are: Galavit Bestim Anaferon Arpetolid Glutoxim Isofon Imudon Actinolysate Immunal Gerbion Vitanam Dezoksinat Broncho-Vaxom Poludan Timalin Methyluracil Immunex Wobenzym Arpeflu Imunofan Cycloferon Erbisol Ribomunil Ruzam Estifan Stemokin Phlogenzym Engistol Echinacea and some other drugs.

Prices

The average price of POLYOXIDONIUM in pharmacies (Moscow) is 700 rubles.

1. Ira

   Polyoxidonium was tested in tablets and suppositories. I drank pills myself, candles for children. And slipped last year's flu and all sorts of viruses. This year I have already purchased the drug, so far there is no hype for such funds. They usually go up in winter.

   I am campaigning for my sister to buy and start drinking, she has a bad reaction to antibiotics, so better prevention hold in advance. She laughs at the name) But the fact that she often gets sick is not at all funny. Since childhood, painful, and immunity on the side.

2. Raisa

   The drug is a dummy and not cheap. She fell ill with the flu, and in addition to treatment with other drugs, she was advised to inject polyoxidonium. I was sick for 10 days no less than always. And the disease was severe. But after I was cured, exactly 10 days later I also fell ill again, this has never happened before. This is a natural dummy and, probably, there are a lot of side effects. It seems to me that he, on the contrary, weakened my immunity. I have never been so sick twice in a month. And don't lie to people about the immune benefits of this drug.

3. Catherine

   Whatever the infection, my husband and I will definitely “catch” it. I'm so tired of constant illness. Friends advised me to drink polyoxidonium just in preventive purposes. For the first time in many months, the spring cold did not touch us. And it was so opportunely - we were just leaving on vacation. I can advise everyone who has the same weakened immune system. We are holding on for now. Hope it lasts a long time.

4. Valery

   My wife and I are not supporters of treatment with pills, but we have seen from our own experience that sometimes there is no other way. We tried to find the most harmless drugs. But those that seem harmless work worse than any antibiotics. We have been looking for this for a long time, and this winter we found a medicine that helped to quickly cope with the flu and recover from the virus. Polyoxidonium is convenient to drink - you just absorb it and that's it. We asked the doctors - the reviews are good, even children can drink it. We plan to drink a course for prevention. Autumn is coming, which means it's time colds. Let's try not to get sick.

5. Katia

   I don't know what I would do without polyoxidonium. I look at the other children in the kindergarten: always in snot, coughing non-stop ... Do parents really like to look at this. For example, I switched to it a long time ago and do not regret it at all. I know 100 percent that my child will not catch the infection. At least it’s not scary to leave it in the garden for the whole day! And everyone who is afraid to use it has long wanted to give the latest research to read.

6. Lolly

   From an early age I suffer from various forms of allergic pathology, so it is very difficult to find a cure, even for a banal flu. Many instructions say that the drug can be used in patients with allergies, but in fact this turns out to be a lie. There were no such incidents with polyoxidonium. Naturally, I was scared to take another drug, but I wanted to find normal pills so much that I took a chance. And not in vain, as I can now judge. I cured the flu without consequences, and did not notice any negative post-effects. Of course, I am also satisfied with the fact that immunity has increased. This year I didn't get sick at all.

7. Renata

   I always carry Polycosidonia with me on trips. I rarely get sick at home, but as soon as I go somewhere, I immediately get a cold with a high temperature. These pills are suitable for both me and my husband, so I know for sure that I can buy a pack and carry it with me just in case. If we still catch a cold, polyoxidonium helps to quickly get back on our feet. The disease passes almost imperceptibly, and most importantly - without complications.

8. oxy

   When complications arise during SARS, it takes a very serious turn. This happened to me for the first time last winter. Now it is difficult to assess what helped more and what helped less, but polyoxidonium is responsible for the fact that I began to feel better after a couple of days. Thank God, this medicine can be administered at any stage of the disease. Of the 3 weeks of non-escape treatment, only the last 7 days, when she took a course of pills, could get out of bed and do housework. It took not so little time to recover, but she was cured without complications and consequences. I got polyoxidonium. The next stage - I'm going to drink it for prevention purposes in the fall. I want to boost my immunity.

9. Larisa

   This fall I have already managed to get sick. But less than a week and I was already at work like a bayonet. I think I got it right in time. Weekends and another 2 days of day off - bed rest, tea, honey, gargling, pills (including polyoxidonium). Last time I took it every year for prevention, but this year I did not expect viruses to come to us so early. But polyoxidonium pulled me out of the illness quite quickly, given that on the first day my temperature was quite high. We must not forget to drink a prophylactic course by the winter.

10. Tatiana

    I had to somehow take polyoxidonium according to the doctor's prescription. The effect is excellent. I was very ill then, then I quickly began to recover, and after completing the course, I fell ill with ARVI only in April. And all winter, when our office went on sick leave, I was like a cucumber, not a sneeze or a cough.

11. Miroslava

    The basic principle of polyoxidonium is the rapid activation of immunity, which is expressed in the production of interferon. Polyoxide begins to work within three hours after taking it, i.e. after three hours, your interferon begins to fight viruses. Due to this, the recovery is faster. I have been using this drug for two years now, when I start to get ARVI. The effectiveness is noticeable already on the second day - the state of health improves, the fever stops, the temperature drops. By the way, this comes from the fact that polyoxidonium, in addition to activating immunity, removes viral toxins.

12. Nataliya

    After they completed the course of polyoxidonium, my son became much less likely to get sick in the kindergarten. Whole last year he got sick almost every month. And this year, since the beginning of September, he fell ill only once, and then he didn’t get sick for very long, five days.

13. Silvia

    A friend once told me about polyoxidonium. This drug was prescribed for her daughter when she fell ill with SARS and then complications arose. I remember this, and I remembered it when my son got sick. Our pediatrician confirmed that this is a good antiviral drug and that if you follow the scheme, he will raise his son to his feet in just a couple of days. It was hard to believe, after all, these are just pills, not magic powder))) But they really worked like that, and if I was used to treating a child for weeks, then everything went away in less than a week. Result? Result.

    15.12.2018

    Well, of course, everyone likes their own way of dealing with orvi, someone can help polyoxidonium, but I don’t. Therefore, I take Ingavirin, with it recovery comes much faster.

14. Alyona

    At the beginning of the year, she started being treated with Polyoxidonium for HPV. Is it a fashion for doctors to prescribe it from everything and everything? So I became a victim of this fashion. And of course, he did not cope with the virus. Again, the numbers are on the rise. As I understand it, the maximum that people are treated for is a cold.

The immune system of the child controls all the processes that occur in his body. It not only protects against influence external factors- viruses, bacteria, fungi. Immunity regulates the constancy of the internal environment of the body.

Polyoxidonium ─ immunomodulator, synthetic medicinal product restoring protective forces. In composition, it is similar to substances that are produced by the immune system and enhance its response mechanism. It is the body's internal defense corrector.

Polyoxidonium is an immunomodulating agent.

The composition of the drug

Polyoxidonium is a brand name, and the active substance on which the action of the drug is based is azoximer bromide. It stimulates the immune system and removes toxins.

Dosage forms:

Mandatory additional components for all forms of release:

• mannitol - it acts as a diuretic, increases the volume of urine, which reduces intoxication with influenza or SARS;
• povidone ─ binds toxins into complexes and removes them through the intestines;
• betacarotene is an analogue of vitamin A, stimulates the immune system, adapts the child's body to fight infection.

Additional components in the composition of tablets;

• lactose monohydrate ─ used as a filler, improves metabolic processes, normalizes the intestinal microflora, stimulates the nervous system;
• potato starch ─ filler for tablets;
• stearic acid ─ stabilizer for solid forms.

The basis for rectal suppositories is cocoa butter.

Pharmacological action of the drug

Polyoxidonium increases the resistance of the child's body to local (the pathogen is located on the mucous membranes of the respiratory tract) and generalized (the virus has spread throughout the body) infection.

Doctors advise taking the drug with weak immunity.

The drug directly affects phagocytes, cells that absorb viruses, stimulates the formation of antibodies.

Polyoxidonium restores the protective mechanisms of the baby's immune system, which are violated in such conditions:

• infections;
• burns;
• trauma;
• tumors;
• complications after operations;
• chemotherapy.

The drug is active removes toxins from the child's body. This is provided by its molecular structure.

Indications

The drug is prescribed to children from 6 months.

As an independent remedy, Polyoxidonium is prescribed for babies with recurrent herpes infection. He is also assigned for seasonal prevention of SARS and influenza 2-3 months before the expected epidemic.

Polyoxidonium will help with relapses of herpes.

Indications for the use of the drug as part of complex therapy:

• severe forms of bacterial, viral, fungal infection;
• frequent relapses of chronic infectious diseases in the stage of exacerbation or remission;
• allergic diseases ─ bronchial asthma, hay fever,;
• inflammatory processes of the urinary tract;
• all forms of tuberculosis, rheumatism;
• non-healing burns, ulcers, complicated fractures;
• chemotherapy;
• protection of the kidneys and liver from exposure to toxic pharmacological agents;
• the frequency of colds more than 6 times a year.

Caveats:

• You can not treat with the drug newborn children, and babies up to 6 months. It is prescribed with caution if a small patient has severe kidney disease. Potential risks must be taken into account.
• If the treatment does not deviate from the prescribed scheme, then the likelihood of side effects is zero.

Anatoly Sergeevich Kuznetsov, pediatrician, doctor the highest category from Volgograd recommends:

“In my many years of medical practice, I had to deal with serious disorders in the functioning of the immune system of children. Every year there is a tendency for an increase in immunity deficiency in the smallest patients. In addition to general strengthening measures, there was a need for medical adjustment of the protective functions of the body. Polyoxidonium has proven itself as effective drug to restore immunity. Unlike analogues, it has no side effects, is safe and well tolerated by babies.

The drug is well tolerated by children of all ages.

Margarita, Nizhny Novgorod, writes:

“My child has had surgery. The condition was difficult. Prolonged bed rest. To restore strength and maintain the body, the attending physician prescribed us Polyoxidonium. Improvement in the condition became noticeable already on the third day. Recovery and rehabilitation were easier and faster than we predicted. When discharged home, the baby felt well. Thanks to the doctor and the drug.

Manufacturer and prices

Polyoxidonium was created in Russia. The production license belongs to NPO Petrovax Pharm LLC.

Prices (average):

1. Lyophilizate:
   • 3 mg ─ 629-697 rubles;
   • 6 mg ─1110-1192 rub.
2. Candles:
   • 6 mg - 830-900 rubles;
   • 12 mg ─ 1015-1110 rubles.
3. Tablets ─ 715-760 rubles.

Dosage

The drug is produced in different forms, so the dosage is easy to choose for small patients of any age.

Candles

This form is the most suitable for children up to 6 years old. At this age, they cannot swallow the pill on their own, the risk of inhalation remains. Suppositories are a good alternative for a baby not to give pills. In the rectum, the drug is absorbed faster than in the stomach, so the effect is immediate. The torpedo shape makes the insertion of the suppository quick and painless. Cocoa butter gives a slight smell.

Children under 12 years of age are prescribed suppositories ─ 6 mg, at night, preferably after a bowel movement. The course of treatment is on average 10-20 suppositories. The scheme is prescribed by the doctor on an individual basis.

For the treatment of children, candles are most often prescribed.

Lyophilisate

Lyophilizate is a dry substance for the preparation medicinal solution. Lyophilization is a method of soft drying of a substance, which makes it possible to obtain a dry preparation without loss of biological activity.

The color of Polyoxidonium is from white to bright yellow. Crystals are sensitive to sunlight, easily absorb and retain atmospheric moisture upon contact with air. To prevent the medicine from spoiling, you must follow the storage rules prescribed in the instructions for use. A solution for drops and injections is prepared from the powder.

Intramuscularly or intravenously, the dose is calculated by the doctor, taking into account the weight of the child. The course is 5-10 injections.

Nose drops can be prepared independently at home. Vial (3 mg) diluted in 1 ml of saline (NaCl 0.9%), distilled or boiled water. Drip 1-3 drops in each nostril or under the tongue up to 4 times a day.

Ready drops are stored for a week in the refrigerator. The duration of treatment is up to 10 days. Usually improvement occurs on the fourth day.

The lyophilisate is used as part of complex therapy for the prevention of acute respiratory infections and influenza.

Tablets

Tablets are cylindrical and flattened in shape. By color ─ white, yellowish, impurities (orange blotches) are allowed. Dosage - 12 mg.

Take 1 tablet half an hour before meals 1-3 times a day. The course of treatment for colds is 10-14 days. Prophylactic reception 3 weeks.

Attention! If the doctor has prescribed pills, then the child must take them strictly in the presence of parents and under their control.

The tablet can be swallowed or placed under the tongue until completely dissolved.at

Anna from Moscow writes:

“I am a mother of two children aged 4 and 7. Life in the metropolis ─ This is a constant confrontation with all kinds of infections. With the onset of cold weather, my sons almost continuously suffer from colds. The younger one has frequent sore throats with high fever. Our family doctor advised Polyoxidonium, suppositories and nasal drops. The result was not long in coming. After a two-week course of treatment, the boys feel great. Now we will drink the drug in tablets for prevention.

The benefits of the drug

The drug in pediatric practice have been in use since 2004. Long-term observations during the treatment of children led to the conclusion that, in comparison with other immunomodulators, Polyoxidonium has the following advantages:

• increases efficiency complex treatment recurrent infections and immunodeficiency diseases;
• speeds up the healing process;
• reduces the need to use antibiotics for diseases of moderate severity;
• reduces the frequency of acute respiratory viral infections in children in the autumn-winter period;
• promotes mucus expulsion viral diseases respiratory tract, acts as an expectorant.

The drug accelerates the discharge of sputum in bronchitis.

The most common misconceptions about the impact of Polyoxidonium on the children's body

• It is mistakenly believed that the drug enters into a relationship with the cells of the body and increases the rate of their division. And supposedly as a result, too intensive physical development of the baby occurs.
• The unfounded opinion that with prolonged use of Polyoxidonium provokes the development of oncological diseases.
• Another misconception is that the child's body perceives the components of the drug as a foreign substance, as a result of which an immune reaction is produced in the form inflammatory process and intoxication.
• It is widely believed that the drug causes allergic reactions. Polyoxidonium contains lactose. In some children, this leads to digestive disorders. However, its amount in the preparation is insignificant for the development allergic reactions and intolerance.

Polyoxidonium analogues

Preparations with similar action:

• ─ improves the balance of the immune system, relieves inflammation, slows down the development of the tumor process. Appoint children from 4 years old for the treatment of colds in the form of tablets or injections. Price ─ 137-806 rubles.
• Imunofan ─ suppositories are used to prevent immunity deficiency, as part of an antiviral and antibacterial treatment. Contraindicated in children under 2 years of age. Release form ─ suppositories, ampoules for injections, nasal spray. Price ─ 485-950 rubles.
• ─ a universal drug, not only strengthens the immune system, but also treats many inflammatory diseases. Assigned from birth. Contraindications ─ allergy to components, age up to 6 months. Release form ─ tablets. Price ─ 650-1330 rubles.

In most cases, immunity problems manifest themselves when the child begins attending preschool. The attack of a viral infection is primarily exposed to children who were born prematurely or with low birth weight. High level colds is explained by the fact that babies lack immunological memory.

Polyoxidonium is the first aid to the fragile children's body. The fundamental difference between the drug and analogues is that it is used not only for the treatment of chronic infections, but also for acute viral, bacterial and fungal diseases.

Natalia Avramenko

Porous mass from white with a yellowish tinge to yellow. The drug is hygroscopic and photosensitive.

Pharmacotherapeutic group

Immunomodulators

ATX code L03

Pharmacological properties"type="checkbox">

Pharmacological properties

Pharmacokinetics

With intramuscular administration of azoximer, bromide has a high bioavailability (89%); the time to reach the maximum concentration in the blood is 40 minutes. The half-life in the body (fast phase) is 0.44 hours, the half-life (slow phase) is 36.2 hours. In the body, the drug is rapidly distributed to all organs and tissues, hydrolyzed to oligomers, which are excreted mainly by the kidneys.

Pharmacodynamics

Polyoxidonium® has an immunomodulatory effect, increases the body's resistance to local and generalized infections. The basis of the mechanism of the immunomodulatory action of the drug Polyoxidonium® is a direct effect on phagocytic cells and natural killers, as well as stimulation of antibody production.

Polyoxidonium® restores immunity in secondary immunodeficiency conditions caused by various infections, injuries, burns, autoimmune diseases, malignant neoplasms, complications after surgical operations, the use of chemotherapeutic agents, cytostatics, steroid hormones.

Along with the immunomodulatory effect, Polyoxidonium® has detoxifying and antioxidant activity, which is determined by the structure and high-molecular nature of the drug. The use of Polyoxidonium® in complex therapy improves the effectiveness and reduces the duration of treatment, significantly reduces the use of antibiotics, bronchodilators, glucocorticosteroids, and prolongs the period of remission.

The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have an allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effect.

Indications for use

Correction of immunity in adults and children from 6 months.

In adults, 6 mg in complex therapy:

Chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the acute stage and in remission;

Acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);

tuberculosis;

Acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis) complicated by chronic recurrent bacterial and viral infection;

Rheumatoid arthritis, long-term treated with immunosuppressants; with rheumatoid arthritis complicated by SARS;

In oncology during and after chemotherapy and radiation therapy to reduce the immunosuppressive, nephro- and hepatotoxic effects of drugs;

To activate regenerative processes (fractures, burns, trophic ulcers);

For the prevention of postoperative infectious complications;

For the prevention of influenza and SARS.

In children from 6 months 3 mg in complex therapy:

Acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including JIOP-organs - sinusitis, rhinitis, adenoiditis, pharyngeal tonsil hypertrophy, SARS);

Acute allergic and toxic-allergic conditions;

Bronchial asthma complicated by chronic infections of the respiratory tract;

Atopic dermatitis complicated by purulent infection;

Intestinal dysbacteriosis (in combination with specific therapy);

For the rehabilitation of often and long-term sick people;

Prevention of influenza and SARS.

Dosage and administration

For adults:

Methods of application of the drug Polyoxidonium®: parenteral, intranasal. Methods of application are chosen by the doctor depending on the severity of the disease and the age of the patient.

Intramuscularly or intravenously (drip): the drug is prescribed for adults in doses of 6-12 mg 1 time per day, every day, every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.

For intramuscular administration, the contents of the vial are dissolved in 1.5-2 ml of 0.9% sodium chloride solution or water for injection.

For intravenous (drip) administration, the drug is dissolved in 2 ml of 0.9% sodium chloride solution, then sterilely transferred into a vial with the indicated solutions with a volume of 200-400 ml.

Intranasally, the drug is prescribed daily at a dose of 6 mg per day; a dose of 6 mg is dissolved in 1 ml (20 drops), 0.9% sodium chloride solution, distilled water or boiled water room temperature. The prepared solution is stored in the refrigerator for 12 hours, before use, warm to room temperature.

Parenterally:

In acute inflammatory diseases: 6 mg daily for 3 days, then every other day with a total course of 5-10 injections.

In chronic inflammatory diseases: 6 mg every other day of injection, then 2 times a week with a course of at least 10 injections.

For tuberculosis: 6-12 mg 2 times a week in a course of 10-20 injections.

In patients with acute and chronic urogenital diseases: 6 mg every other day with a course of 10 injections in combination with chemotherapy drugs.

In chronic recurrent herpes: 6 mg every other day in a course of 10 injections in combination with antiviral drugs, interferons and/or inducers of interferon synthesis.

For the treatment of complicated forms of allergic diseases: 6 mg, a course of 5 injections: the first two injections daily, then every other day. In acute allergic and toxic-allergic conditions, administer intravenously at 6-12 mg in combination with antiallergic drugs.

In rheumatoid arthritis: 6 mg every other day, 5 injections, then 2 times a week with a course of at least 10 injections.

In cancer patients: before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6-12 mg every other day with a course of at least 10 injections; for the prevention of the immunosuppressive effect of the tumor, for the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor long-term use the drug Polyoxidonium® (from 2-3 months to 1 year) 6-12 mg 1-2 times a week. The frequency and duration of administration is determined by the doctor depending on the tolerability and duration of chemotherapy and radiation therapy.

In patients with acute renal failure appoint no more than 2 times a week.

Intranasally prescribed 6 mg per day for the treatment of acute and chronic infections of JIOP-organs, to enhance the regenerative processes of the mucous membranes, to prevent complications and relapses of diseases, to prevent influenza and SARS. 3 drops in each nasal passage after 2-3 hours (3 times a day) for 5-10 days.

Dosage and administration for children

Methods of using the drug Polyoxidonium® are chosen by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient: parenterally, intranasally, sublingually.

Parenterally (intramuscularly or intravenously drip), the drug is prescribed to children from 6 months at a dose of 0.1-0.15 mg / kg daily, every other day or 2 times a week, depending on the severity of the disease, with a general course of 5-10 injections. The maximum daily dose is 3 mg.

The calculation of the dose in ml per child's weight is indicated in the table (third column).

For intramuscular injection, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.

For intravenous drip administration, the drug is dissolved in 1.5-2 ml of a sterile 0.9% sodium chloride solution, sterilely transferred into a vial with the indicated solutions with a volume of 150-250 ml.

The prepared solution for parenteral administration is not subject to storage.

Sublingual: daily 1 time per day at a dose of 0.15 mg/kg for 10 days.

Intranasally daily at daily dose 0.15 mg/kg for 5-10 days. The drug is administered 1-3 drops in each nasal passage after 2-3 hours, 2 times a day until the daily dose indicated in the table below is reached.

To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop of the prepared solution contains 0.05 ml of the drug Polyoxidonium®, which is prescribed per 1 kg of the child's body weight.

The solution for sublingual and intranasal use should be stored in the refrigerator for no more than 7 days. Before use, the pipette with the solution should be heated to room temperature (20-25 °C).

In acute inflammatory diseases: intramuscularly or intravenously by drip at 0.1 mg / kg every other day with a course of 5-7 injections.

In chronic inflammatory diseases: intramuscularly at 0.15 mg / kg 2 times a week with a course of up to 10 injections.

In acute allergic and toxic-allergic conditions: intravenous drip at a dose of 0.15 mg / kg daily for 3 days, then every other day with a course of 5-7 injections in combination with antiallergic drugs.

For the treatment of complicated forms of allergic diseases in combination with basic therapy: intramuscularly at 0.1 mg/kg in a course of 5 injections with an interval of 48 hours.

For the treatment of intestinal dysbacteriosis sublingually daily at a daily dose of 0.15 mg/kg for 10-20 days.

1-3 drops are administered intranasally into each nasal passage after 1-2 hours (2 times a day) for 5-10 days:

For the treatment of acute and chronic infections of JIOP-organs (sinusitis, rhinitis, adenoiditis, tonsillitis, SARS, etc.);

For the prevention of infectious complications and relapses;

Diseases during preoperative preparation of patients and postoperative treatment;

To enhance the regenerative processes of the mucous membranes;

For the prevention of SARS and influenza.

Side effects"type="checkbox">

Side effects

Soreness at the injection site when administered intramuscularly.

Contraindications

Individual hypersensitivity;

Pregnancy and lactation (no clinical experience).

Carefully:

Acute renal failure;

Children under 6 months of age (limited clinical experience)

Polyoxidonium is a drug with detoxifying, antioxidant and immunomodulatory effects.

Release form and composition

Dosage forms of Polyoxidonium release:

• Tablets: flat-cylindrical, with a chamfer, on one side - a risk, on the other - the inscription "PO", from yellow with an orange tint to white with a yellowish tint, there may be barely noticeable blotches that have a more intense color (10 pcs. in contour cells packages, 1 package in a carton box);
• Lyophilisate for solution for injection and local application: porous, hygroscopic, photosensitive, from yellow to white with a yellowish tint (3 mg each, in glass bottles of 4.5 mg, 6 mg, in glass bottles of 9 mg, 5 bottles in a carton box, or 5 vials in blister packs, 1 pack in a carton box, or 5 vials complete with a solvent (5 ampoules with 0.9% sodium chloride solution) in a carton box);
• Suppositories: light yellow in color, torpedo-shaped, have a slight specific smell of cocoa butter (5 pcs in blister packs, 2 packs in a carton box).

The composition of 1 tablet includes:

• Active substance: azoxymer bromide (polyoxidonium) - 12 mg;
• Auxiliary components: mannitol, betacarotene, povidone, lactose monohydrate, potato starch, stearic acid.

The composition of 1 vial with lyophilizate includes:

• Active substance: azoxymer bromide (polyoxidonium) - 3 or 6 mg;
• Auxiliary components: povidone, mannitol, betacarotene.

The composition of 1 suppository includes:

• Active substance: azoxymer bromide (polyoxidonium) - 6 or 12 mg;
• Auxiliary components: povidone, betacarotene, mannitol, cocoa butter.

Indications for use

Tablets
Polyoxidonium is prescribed for infectious and inflammatory diseases of viral, fungal and bacterial origin, when standard therapy is ineffective, as well as during exacerbation (treatment) and remission (prevention), in adults and children over 12 years old.

As part of complex treatment:

• Infectious and inflammatory diseases of the paranasal sinuses, oropharynx, upper respiratory tract, middle and inner ear in acute and chronic course;
• Allergic diseases complicated by recurrent infections of bacterial, viral and fungal origin (including pollinosis, bronchial asthma);
• Rehabilitation for a long time and often (from 4-5 times a year) for sick people.

Monotherapy:

• Chronic infections of the middle and inner ear, oropharynx, upper respiratory tract, paranasal sinuses (seasonal prevention of exacerbations);
• Recurrent herpetic infection (prevention);
• Secondary immunodeficiencies associated with aging or exposure to adverse factors (correction);
• Flu and other acute respiratory infections in immunocompromised individuals in the pre-epidemic period (prevention).

Polyoxidonium is prescribed for the correction of immunity in adults and children from 6 months.

As part of complex treatment in adults:

• Tuberculosis;
• Chronic recurrent infectious and inflammatory diseases that are not amenable to standard treatment during exacerbation and in remission;
• Viral and bacterial infections in acute and chronic course (including urogenital diseases of an infectious and inflammatory nature);
• Allergic diseases in acute and chronic course (including pollinosis, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infection;
• Application medicines in oncology during and after radiation and chemotherapy (to reduce immunosuppressive, hepato- and nephrotoxic effects);
• Burns, fractures, trophic ulcers (in order to activate regenerative processes);
• Rheumatoid arthritis, long-term treated with immunosuppressants, as well as with complications of acute respiratory diseases;
• infectious complications in postoperative period(prevention);

As part of complex treatment in children:

• Inflammatory diseases caused by pathogens of bacterial, fungal and viral infections (including ENT organs - adenoiditis, rhinitis, sinusitis, pharyngeal tonsil hypertrophy, acute respiratory viral infections);
• Allergic and toxic-allergic conditions in acute course;
• Bronchial asthma complicated by chronic respiratory tract infections;
• Intestinal dysbacteriosis (simultaneously with specific therapy);
• Atopic dermatitis complicated by purulent infection;
• Rehabilitation of long-term and frequently ill persons;
• Influenza and acute respiratory infections (prevention).

suppositories
Polyoxidonium is prescribed for the correction of immunity in adults and children from 6 years of age.

As part of complex treatment for patients of all ages:

• Chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy during exacerbation and during remission;
• Viral, bacterial and fungal infections in acute course;
• Inflammatory diseases of the urogenital tract, including urethritis, pyelonephritis, cystitis, endomyometritis, prostatitis, cervicitis, salpingoophoritis, cervicosis, colpitis, bacterial vaginosis, incl. viral etiology;
• Various forms of tuberculosis;
• Allergic diseases complicated by recurrent bacterial, fungal and viral infections, including bronchial asthma, hay fever, atopic dermatitis;
• Rheumatoid arthritis, including long-term treatment with immunosuppressants, as well as complicated by acute respiratory diseases;
• Activation of regenerative processes in burns, fractures, trophic ulcers;
• Rehabilitation for a long time and often (from 4-5 times a year) of sick people;
• After the use of immunosuppressive, hepato- and nephrotoxic drugs in oncology, as well as during and after the end of radiation and chemotherapy treatment (to reduce their harmful effects).

As part of complex treatment for all age groups of patients:

• Recurrent herpetic infections (prevention);
• Influenza and acute respiratory diseases in the pre-epidemic period (prevention);
• Exacerbation of chronic foci of infections (seasonal prevention);
• Secondary immunodeficiencies developed due to aging or under the influence of adverse factors (correction).

Contraindications

• Age up to 12 years (tablets);
• Pregnancy and lactation (due to the lack of clinical data on the safety and efficacy of Polyoxidonium in this category of patients);
• Hypersensitivity to the components of the drug.

Caution must be observed when prescribing the drug against the background of the following diseases / conditions:

• Acute renal failure;
• Lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome (tablets);
• Age up to 6 months (lyophilisate for solution, due to limited clinical experience use in this group).

Method of application and dosage

Tablets
Polyoxidonium should be administered orally and sublingually, preferably 20-30 minutes before a meal.

Average single doses:

• adults -12 or 24 mg;
• children from 12 years old - 12 mg.

The multiplicity of reception - from 1 to 3 times a day (with a double dose, you must observe a break of 12 hours, three times - 8 hours).

The doctor determines the method and dosage regimen individually based on the indications, severity and severity of the process.

Sublingually, Polyoxidonium is taken as follows (frequency of administration / single dose / duration of therapy):

• Inflammatory diseases oral cavity and sips: 2 times a day / 1 tablet / 10-14 days;
• Herpetic or fungal infections of the oral cavity in severe forms: 3 times a day / 1 tablet / 15 days;
• Sinusitis and otitis in chronic course: 2 times a day / 1 tablet / 5-10 days;
• Chronic tonsillitis: 3 times a day / 1 tablet / 10-15 days;
• Diseases of the upper respiratory tract in a chronic course: 2 times a day / adults - 2 tablets, children from 12 years old - 1 tablet / 10-14 days;
• Influenza and acute respiratory infections in immunocompromised patients with acute respiratory infections more than 4 times a year (for prophylaxis in the pre-epidemic period): adults - 2 times a day / 2 tablets, children from 12 years old - 2 times a day / 1 tablet / 10 -15 days.

Oral administration of Polyoxidonium is indicated in the treatment of diseases of the upper respiratory tract in a chronic course (prescribed similarly to sublingual administration).

Lyophilisate for solution preparation
Polyoxidonium in the form of a solution is used parenterally, sublingually and intranasally.

The doctor sets the dosage regimen and the route of administration of the solution individually, taking into account the diagnosis, age and weight of the patient, and the severity of the course of the disease.

Intramuscular or intravenous (drip) administration:

Polyoxidonium is prescribed daily, every other day or 1-2 times a week, the frequency of administration is 1 time per day:

• adults - 6-12 mg,
• children from 6 months - 3 mg (0.1-0.15 mg / kg).

• Acute inflammatory diseases: adults - daily for 3 days, 6 mg, then every other day, 5-10 injections per course; children - every other day at 0.1 mg / kg, 5-7 injections per course;
• Chronic inflammatory diseases: adults - daily for 5 days, 6 mg, then 2 times a week, up to 10 injections per course; children - 2 times a week, 0.15 mg / kg, up to 10 injections per course;
• Tuberculosis: adults - 2 times a week, 6-12 mg, 10-20 injections per course;
• Urogenital diseases in acute and chronic course: adults - every other day, 6 mg, 10 injections per course simultaneously with chemotherapy;
• Recurrent herpes in a chronic course: adults - every other day, 6 mg, 10 injections per course simultaneously with antiviral drugs, interferons and interferon synthesis inducers;
• Allergic diseases in complicated forms: adults - daily for 2 days, 6 mg, then every other day, course - 5 injections; children - intramuscularly at 0.1 mg / kg with an interval of 1-2 days simultaneously with basic therapy, 5 injections per course;
• Acute allergic and toxic-allergic conditions: adults - intravenously at 6-12 mg; children - intravenously drip at a dose of 0.15 mg / kg. Therapy is carried out simultaneously with antiallergic drugs;
• Rheumatoid arthritis: adults - 5 injections every other day, 6 mg, then 2 times a week, up to 10 injections per course;
• Immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents (before and during chemotherapy to reduce the severity of reactions): adults - every other day, 6-12 mg, up to 10 injections per course; in the future, the doctor determines the frequency of administration individually, depending on the tolerability and duration of chemotherapy and radiation therapy;
• Prevention of immunosuppressive action caused by the tumor process, correction of immunodeficiency after chemotherapy and radiation therapy, surgical removal of tumors: adults - 1-2 times a week, 6-12 mg, long-term therapy (2-12 months) is indicated.

In acute renal failure, Polyoxidonium is prescribed no more than 2 times a week.

To prepare a solution for intramuscular injection, the lyophilizate must be dissolved in water for injection or 0.9% sodium chloride solution in a ratio of 6 mg / 1.5-2 ml (for adults) or 3 mg / 1 ml (for children).

To prepare a solution for intravenous (drip) administration, the lyophilizate can be dissolved in a 0.9% sodium chloride solution, gemodeze-N, rheopolyglucin or 5% dextrose solution. After dissolution under sterile conditions, it is necessary to transfer the solution to a vial with the indicated solutions. Ratio (dose of Polyoxidonium / volume of solution for dissolving the lyophilizate / total volume of solution): adults - 6 mg / 2 ml / 200-400 ml; children - 3 mg / 1.5-2 ml / 150-250 ml.

The prepared solution should be administered immediately (can not be stored).

Intranasal and sublingual application
In the treatment of acute and chronic infectious diseases of the ENT organs, to enhance the regenerative processes of the mucous membranes, prevent relapses and complications of diseases, prevent influenza and acute respiratory diseases, Polyoxidonium is prescribed intranasally:

• Adults: in each nasal passage, 3 drops 3 times a day, a break between injections - 2-3 hours;
• Children: in one nasal passage, 1-3 drops 2-4 times a day (0.15 mg / kg per day), the interval between injections is 2-3 hours.

The duration of the course is 5-10 days.

Sublingually for children, according to all indications, Polyoxidonium is prescribed at 0.15 mg / kg per day (1-3 drops under the tongue every 2-3 hours). The drug is taken daily. Course duration - 10 days, with intestinal dysbacteriosis - 10-20 days.

To prepare a solution for topical use (intranasal and sublingual) Polyoxidonium is dissolved in distilled water, 0.9% sodium chloride solution or boiled water at room temperature.

Ratio:

• adults - 6 mg of lyophilisate / 1 ml of solution or water (20 drops);
• children - 3 mg of lyophilisate / 1 ml of solution or water (20 drops).

The resulting solution can be used within 7 days if stored in the refrigerator. Before use, the solution (single dose in a pipette) should be warmed to room temperature (20-25 ° C).

suppositories
Polyoxidonium is used rectally (into the rectum after a bowel movement) and intravaginally (into the vagina, in the supine position, at night): 1 suppository 1 time per day. Frequency of application: daily, every other day or 2 times a week.

The doctor determines the dosage regimen individually, based on the diagnosis, severity and severity of the process.

Depending on the dosage, suppositories are prescribed:

• 12 mg each: for adults rectally and intravaginally;
• 6 mg: children from 6 years of age rectally; adults (as maintenance therapy) rectally and intravaginally.

As a rule, Polyoxidonium is prescribed 1 suppository (6 or 12 mg) daily for 3 days, then every other day with a course of 10-20 suppositories. It is possible to repeat therapeutic courses in 3-4 months.

In chronic immune deficiency (including those receiving long-term immunosuppressive therapy, with oncological diseases, HIV, after irradiation), long-term maintenance therapeutic courses (2-12 months) are indicated:

• adults - 12 mg;
• children from 6 years old - 6 mg.

Multiplicity of application - 1-2 times a week.

Simultaneously with other drugs, Polyoxidonium is prescribed as follows:

• Chronic infectious and inflammatory diseases: with exacerbations - according to the standard scheme, with remission - after 1-2 days, 12 mg, 10-15 suppositories per course;
• Acute infectious processes, as well as burns, fractures, trophic ulcers (to activate regenerative processes): 1 suppository daily, 10-15 suppositories per course;
• Tuberculosis: according to the standard scheme, at least 15 suppositories per course. In the future, maintenance therapy is possible: 2 suppositories per week, the duration of the course is up to 2-3 months;
• Against the background of chemotherapy and radiation therapy of tumors: 1 suppository daily 48-72 hours before the start of the course of therapy. In the future, the doctor determines the dosage regimen individually;
• Rehabilitation for a long time and often (more than 4-5 times a year) of sick people, rheumatoid arthritis: every other day, 1 suppository, 10-15 suppositories per course;
• Correction of secondary immunodeficiencies, incl. arising as a result of aging: 2 times a week, 12 mg; at least 10 suppositories per course. The therapy is repeated 2-3 times a year.

• Seasonal prevention of exacerbations of chronic infectious diseases, prevention of recurrent herpes infection: every other day, adults - 6-12 mg, children - 6 mg, 10 suppositories per course;
• Correction of secondary immunodeficiencies, prevention of influenza and acute respiratory diseases, gynecological diseases: according to the standard scheme.

Side effects

When using Polyoxidonium in the form of tablets and suppositories according to the indications and in compliance with the recommended doses adverse reactions have not been identified.

With intramuscular administration of the solution, local reactions can be observed in the form of pain at the injection site.

special instructions

Without consulting a specialist, the indicated doses and the duration of the course should not be exceeded.

drug interaction

Information on the interaction of Polyoxidonium with other drugs / substances is not presented.

Polyoxidonium is an immunostimulating agent that increases the body's resistance to local and generalized infections. Instructions for use prescribe the use of 12 mg tablets, 6 mg and 12 mg suppositories, injections in ampoules for injections of 3 mg and 6 mg to increase the body's resistance to infectious pathologies. Patient reviews and doctors' recommendations indicate that this drug helps in the treatment of immunodeficiencies and related infectious diseases.

Release form and composition

Produce the following dosage forms Polyoxidonium:

• Tablets 12 mg.
• Candles for vaginal or rectal application 6 mg and 12 mg.
• Lyophilisate for solution for injection and topical application (injections in ampoules) 3 mg and 6 mg.

The active substance is azoximer bromide (polyoxidonium):

• vial of lyophilisate - 3 mg or 6 mg;
• tablet - 12 mg;
• suppository - 6 mg or 12 mg.

pharmachologic effect

The drug Polyoxidonium helps to restore the immune status in secondary immunodeficiency states, which are caused by various infections, trauma, burns, malignant tumors, complications after surgical interventions, treatment with the use of chemotherapeutic drugs, including but not limited to cytostatic agents and steroid hormones.

Along with the immunocorrective effect of azoximer, bromide also has a pronounced detoxifying effect, which is due to the structure and high-molecular nature of this substance.

The result of its impact on the body is an increase in the resistance of cell membranes to the cytotoxic (causing cell damage up to their death) action of drugs and chemicals, as well as a decrease in the toxicity of the latter.

The appointment of Polyoxidonium in combination with other drugs increases the effectiveness of therapy by an order of magnitude, reduces its duration, allows you to reduce doses or completely avoid the use of antibiotics, bronchodilators and glucocorticosteroids, and helps to increase the period of remission (that is, the period of weakening or complete disappearance of symptoms of the disease).

The drug is well tolerated by patients, does not show mitogenic or polyclonal activity, does not have antigenic properties, does not provoke the development of allergies, mutations and other defects in the development of the fetus, does not have a teratogenic effect on the developing fetus, does not have carcinogenic and embryotoxic properties.

Why is Polyoxidonium prescribed?

Indications for the use of the drug include the correction of immunity in adults and children from 6 months.

What helps children? In complex therapy, pediatricians prescribe the drug:

• intestinal dysbacteriosis (in combination with specific therapy);
• atopic dermatitis complicated by purulent infection;
• prevention of influenza and acute respiratory infections;
• acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, SARS);
• for the rehabilitation of often and long-term sick people;
• acute allergic and toxic-allergic conditions;
• bronchial asthma complicated by chronic respiratory tract infections.

In adults in complex therapy:

• acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
• with complicated acute respiratory infections during rheumatoid arthritis;
• to activate regenerative processes (fractures, burns, trophic ulcers);
• for the prevention of influenza and acute respiratory infections;
• for the prevention of postoperative infectious complications;
• chronic recurrent infectious and inflammatory diseases that are not amenable to standard therapy in the acute stage and in remission;
• tuberculosis;
• in oncology during and after chemotherapy and radiation therapy to reduce the immunosuppressive, nephro- and hepatotoxic effects of drugs;
• acute and chronic allergic diseases (including pollinosis, bronchial asthma, atopic dermatitis) complicated by chronic recurrent bacterial and viral infection;
• rheumatoid arthritis.

Contraindications

The use of Polyoxidonium is contraindicated in patients with hypersensitivity to the components of the drug. Azoximer bromide should be used with caution in the treatment of patients with acute renal failure. Lyophilisate and suppositories should not be administered during pregnancy and breastfeeding.

• Lyophilisate: up to 6 months - with caution.
• Tablets: up to 12 years.
• Candles: children under 6 years.

Instructions for use

Tablets

Polyoxidonium instructions for use prescribe to take orally or sublingually. It is recommended to take half an hour before meals twice a day. Children over the age of 10 years and adult patients are prescribed one tablet each. Children 3-10 years old are prescribed ½ tab. If necessary, and according to the instructions of the doctor, it is possible to repeat the course of treatment in 3-4 months.

sublingual pills

Dosage for the treatment of adult patients and children over 10 years of age:

• Exacerbation of chronic diseases of the upper respiratory organs and otitis is prescribed 1 tablet twice a day for 10 days, for patients 10-18 years old - the duration of therapy is 7 days.
• For the treatment of allergic diseases complicated by fungal, viral or bacterial infection The recommended dose is 1 tab. twice a day for 10 days, and for children 10-18 years old - for a week.
• Influenza and SARS - 1 tablet twice a day for a week.
• Inflammatory lesions of the oropharynx - 1 tab. twice a day for 10 days, children 10-18 years old for 7 days.
• For the treatment of the above diseases in children, ½ tab. twice a day for a week.

Disease prevention:

• Secondary immunodeficiencies: adults - 1 tablet per day for 10 days.
• SARS and influenza: adults - 1 tab. per day for 10 days; children 3-10 years old - ½ tab. per day for a week.
• Herpes of the nasal and labial region: adults - 1 tab. twice a day for 10 days; children 3-10 years old - ½ tab. twice a day for 7 days.
• Exacerbation of chronic infectious diseases of the ear, oropharynx and upper respiratory organs: adults: 1 tab. per day for 10 days; children 3-10 years old - ½ tab., course of treatment - 10 days.

Oral pills

The drug is taken to treat children over 10 years of age and adult patients. The recommended dosage is 1 tablet twice a day for 10 days.

Suppositories Polyoxidonium

Candles 12 mg and 6 mg are administered rectally, after the bowel cleansing procedure, once a day (before bedtime). single dose- one suppository. The scheme of their introduction is as follows: daily one at a time in the first 3 days, then - also one at a time - after 2 days. For a full course, 10 suppositories are required.

Intravaginal application is indicated for the treatment gynecological diseases: dysplasia, erosion, leukoplakia of the cervix, colpitis, adnexitis, endometritis, as well as diseases provoked by human papillomavirus (HPV).

Treatment involves the daily administration of one suppository for three days with a dosage of the active substance of 12 mg, after which the suppositories continue to be administered every other day. The course is carried out using 10 suppositories. In cases where it is advisable, the course of treatment can be repeated after 3-4 months.

Patients who have been diagnosed with chronic immune deficiency (including, but not limited to, patients in whom such a condition was the result of an oncological disease) are prescribed Polyoxidonium as a maintenance agent at a dose of 6 or 12 mg (according to the doctor's indications) 1-2 times a week. The treatment is long.

Lyophilisate

Injections in ampoules are intended for parenteral (intramuscular (IM) or intravenous (IV)), intranasal administration and sublingual administration in children. Solution preparation rules:

V / m administration: for adults - dissolve the contents of 1 vial (6 mg) in 1.5-2 ml of water for injection or 0.9% sodium chloride solution; for children - dissolve 3 mg of the drug in 1 ml of 0.9% sodium chloride solution or water for injection;

In / in drip injection: for adults - dissolve the contents of 1 vial (6 mg) in 2 ml of 5% dextrose solution, 0.9% sodium chloride solution, gemodez-N or reopoliglyukin, then mix with the selected solution in a volume of 200-400 ml; for children - dissolve 3 mg in 1.5-2 ml of 0.9% sodium chloride solution, gemodez-N, rheopolyglucin or 5% dextrose solution, then transfer the resulting solution into a vial with 150-250 ml of the selected solution;

Intranasal administration: for adults - the contents of 1 bottle (6 mg), for children - ½ bottle (3 mg), should be dissolved in 1 ml of 0.9% sodium chloride solution, distilled or boiled water at room temperature.

One drop of the resulting solution for intranasal administration in children contains 0.15 mg of azoximer bromide. This solution is also used for sublingual use, it can be stored for no more than 7 days in the refrigerator, before use, the pipette is heated to room temperature.

Solution for parenteral administration should be prepared before direct use. The route of administration and dose is determined by the doctor based on clinical indications, taking into account the age of the patient. Recommended dosage for parenteral administration:

• Tuberculosis: 6-12 mg 2 times a week, the course of treatment is 10-20 injections;
• Correction of immunodeficiency after surgical removal of the tumor, radiation and chemotherapy, prevention of immunosuppressive action: 6-12 mg 1-2 times a week for a long period. In acute renal failure, the drug should be administered no more than 2 times a week.
• Acute inflammatory pathologies: adults - 6 mg per day for 3 days, then - 1 time in 2 days, only 5-10 injections; children - at the rate of 0.1 mg per 1 kg of the child's weight per day, the procedure is carried out every other day, in total - 5-7 injections;
• Rheumatoid arthritis: 6 mg every other day - 5 injections, then - 2 times a week, at least 10 injections in total;
• Acute and chronic urogenital pathologies: 6 mg every other day, only 10 injections in combination with chemotherapy drugs; Chronic recurrent herpes: 6 mg every other day, the course of therapy is 10 injections with simultaneous administration antiviral agents, interferons and inducers of interferon synthesis;
• Chemotherapy for oncological pathologies: 6-12 mg every other day, the course is at least 10 injections, then the frequency of administration is prescribed individually, taking into account the tolerability and duration of radiation and chemotherapy;
• Complicated forms of allergic diseases: adults - 6 mg 1 time per day for 2 days, then - every other day, only 5 injections; children - intramuscularly at 0.1 mg per 1 kg of body weight per day after 1-2 days, in total - 5 injections in combination with basic therapy;
• Inflammatory diseases of chronic origin: adults - 6 mg 1 time per day every other day (5 injections), then - 2 times a week, the course of treatment - at least 10 injections; children - 0.15 mg per 1 kg of weight every 3 days, the course of treatment - up to 10 injections;
• Acute allergic and toxic-allergic conditions (in / in combination with antiallergic drugs): adults - 6-12 mg, children - 0.15 mg per 1 kg of weight;

Recommended dosing for intranasal administration:

• Adults: 3 drops in each nasal passage 3 times a day for 5-10 days;
• Children: 1-3 drops in one nasal passage 2-4 times a day.

Sublingual intake of the solution for children (for all indications): 0.15 mg per 1 kg of body weight per day for 10 days, and with intestinal dysbacteriosis - 10-20 days.

Side effects

The use of the lyophilisate may cause pain at the injection site.

Children, during pregnancy and lactation

The drug is contraindicated for use during pregnancy and breastfeeding. Experimental studies on animals have not revealed negative influence Polyoxidonium on the fertility of females and males.

Also, no teratogenic and embryotoxic effects of the drug and its effect on the development of the fetus during the entire pregnancy and during lactation were found.

special instructions

For suppositories and tablets.

The patient should be aware that the duration of the course of therapy and the indicated doses should not be exceeded without prior consultation with the attending physician.

For lyophilisate for the preparation of an injection solution.

In case of pain at the injection site with intramuscular injection, Polyoxidonium is dissolved in 1 ml of a 0.25% solution of procaine (provided that the patient is not hypersensitive to procaine). With intravenous (drip) administration, the lyophilisate is not recommended to be dissolved in protein-containing infusion solutions.

All dosage forms are compatible with antiviral, antibiotic, antihistamine and antifungal drugs, GCS, bronchodilators, cytostatics. On the ability to manage complex mechanisms and driving a car, the drug has no effect.

drug interaction

It is allowed to use Polyoxidonium in combination with antibiotics, antiviral and antihistamines, antimycotics, cytostatic, glucocorticosteroid and bronchodilator drugs, β-agonists.

If it is necessary to administer the solution by drip into a vein, it should not be diluted with infusion solutions containing proteins.

Polyoxidonium's analogs

Analogues of the drug according to the mechanism of action:

1. Broncho Wax.
2. Affinoleukin.
3. Neuroferon.
4. Actinolysate.
5. Florexil.
6. Glutaxim.
7. Vilozen.
8. Ribomunil.
9. Engystol.
10. Immunofan.
11. Immunal.
12. Ismigen.
13. Taktivin.
14. Herbion.
15. Cytovir-3.
16. Gepon.
17. Bioaron.
18. Polymuramyl.
19. Bestin.
20. Isophon.
21. Arpetolid.

Holiday conditions and price

The average price of Polyoxidonium (tablets 12 mg No. 10) in Moscow is 570 - 765 rubles. Vaginal and rectal suppositories 6 mg (10 pcs per pack) can be bought for 795-910 rubles, injections - 665-755 rubles. In Kyiv, you can buy medicine for 16 hryvnia, in Kazakhstan - for 245 tenge.

In Minsk, pharmacies offer the drug for 2 bel. ruble. Implemented according to the recipe. Tablets and suppositories belong to the category of over-the-counter drugs, a prescription is required to purchase the lyophilisate.

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