Afobazole method of administration and dosage. Afobazole: indications, application. Review of analogues. Side effects of "Afobazole"

19.07.2020 Recipes

We are surrounded by a huge number of factors that cause stress, anxiety, tension, bad dream, anxiety, depression. Rest and a change of scenery are universal means, but sometimes they are insufficient, they do not bring relief, anxiety conditions intensify, all this affects the usual rhythm of life. At this point, you should consult a doctor. There is nothing shameful and wrong in this, because constant tension negatively affects the whole body, especially suffers the cardiovascular system. If the indications are unambiguous, the doctor may prescribe Afobazol.

Afobazole is a medicine belonging to the group of anxiolytics (tranquilizers). It has a moderate stimulating effect, and at the same time reduces anxiety. Light sedation is more of an adverse reaction than the main manifestation of the use of anxiolytics.

Figure 1 - Afobazole effectively copes with stress, tension, depression and anxiety

Tranquilizers inherently affect benzodiazepine receptors (unlike Afobazole), that is, they depress the nervous system, eliminate bad mood and negate negativity, causing indifference. Moreover, tranquilizers can be addictive, which means that when the course is over, a "withdrawal syndrome" will appear. But do not be afraid of the word "tranquilizer" in the description of the drug. Afobazole is the so-called “mild” or “daytime” tranquilizer. The active component of Afobazole really has a tranquilizing effect, reduces severe anxiety, but does not affect benzodiazepine receptors. That is, Afobazole tablets do not suppress the central nervous system, do not cause addiction, drowsiness, muscle relaxation, do not reduce memory performance, do not dull emotions, and they do not have a withdrawal syndrome.

Afobazole relieves tension from the muscles of hollow organs and reduces the manifestation of vegetative-somatic disorders (dry mouth, sweating, dizziness).

Afobazole is prescribed for therapeutic treatment in people over 18 years of age of anxiety, which is provoked by mental disorders or external traumatic factors. If a person has self-doubt, increased vulnerability and suspiciousness, weak stress resistance and emotional instability, then the effect of Afobazole will be more pronounced.

The condition of a person taking Afobazol improves after about a week of regular use of the drug. The following effects are noted:

  • disappear anxiety, fear;
  • sleep improves;
  • relieves nervous tension, psychological discomfort;
  • the manifestation of vegetative-somatic disorders decreases;
  • improves attention and memory.

Indications

Indications for the appointment of Afobazole are:

  • increased anxiety, mental disorders, unrest not associated with any specific subjects and objects, asthenic neuroses, adaptation disorders;
  • anxiety disorders caused by various dermatological, oncological, somatic (lupus, hypertonic disease, bronchial asthma, IHD, arrhythmia, etc.) and other diseases;
  • anxiety states observed in VVD (in combination with other measures, since drug therapy for vegetative-vascular dystonia only temporarily relieves symptoms, but does not eliminate disturbances in work nervous system);
  • sleep disturbances resulting from increased anxiety;
  • neurocirculatory dystonia (NCD);
  • premenstrual syndrome in women (PMS);
  • alcohol withdrawal (alcohol withdrawal syndrome);
  • nicotine withdrawal.

Contraindications

There are not so many contraindications for Afobazol, but they still exist:

  • hypersensitivity or intolerance to the active substance or any of the auxiliary components of the drug;
  • galactosemia (galactose intolerance);
  • monosaccharide intolerance (glucose-galactose malabsorption);
  • lactase deficiency (lactase deficiency);
  • age up to 18 years;
  • pregnancy and lactation.

Side effects

The list of side effects from taking Afobazole for the most part consists of various kinds of allergic reactions:

  • itching of the skin;
  • dermatitis;
  • urticaria;
  • sneezing
  • rhinitis;
  • angiitis, etc.

Nausea, vomiting, diarrhea, headache may occur.

How to take Afobazole

Afobazole tablets are taken after meals with a glass of clean water. One tablet contains 10 mg of the substance. Per day, according to the instructions for use, you can drink 30 mg. This dose is considered the maximum, and it must be divided into 3 doses during the day.


Figure 2 - How to take Afobzaol correctly

The duration of the therapeutic course is determined solely by the treating specialist. Since Afobazole does not have the ability to accumulate, addiction or dependence on the drug does not appear. That is why, on average, the therapeutic course lasts from 2-4 weeks. If the patient's condition reveals the need for adjustment in taking Afobazole, the doctor may prescribe doubling the daily dose (60 mg) and prolonging treatment up to 3 months. Then a 1-2 week break is required. At this time, the therapeutic effect is maintained.

Pregnancy and breastfeeding period


Figure 3 - Afobzaol is forbidden to be taken by pregnant women

Since there are no reliable clinical research and data on the effect of Afobazole on the body of a pregnant woman, nursing mother, fetus and child, then taking Afobazole is prohibited. During breastfeeding (lactation), as active ingredient Fall into breast milk, it is necessary to consult with the observing obstetrician-gynecologist and transfer the child to artificial mixtures.

Alcohol


Figure 4 - Taking alcohol with Afobazole

Instructions for use Afobazole does not prohibit the intake of alcohol, which distinguishes it from other tranquilizers. But it is worth remembering that alcoholic beverages negatively affect the central nervous system, increase anxiety, irritability, suspiciousness and symptoms of various diseases.

Analogues

The pharmaceutical market provides quite wide range analogues of Afobazole according to therapeutic effect. Among these drugs, Fabomotizol, Tenoten, Grandaxin, Stresam, Mebikar, Adaptol, Tranquilar, Novo-Passit, Grandaxin, Persen, Phenibut can be distinguished. Their effectiveness in a particular clinical case can only be assessed by the attending physician. It all depends on individual tolerance. active ingredient and components, the patient's well-being, the individual characteristics of his body, the severity of symptoms. Therefore, before buying a drug in a pharmacy or replacing one with another, consult your doctor.

Figure 5 - Analogues of Afobazole in terms of therapeutic effect

Adaptol, for example, as well as Afobazol, is effective, low-toxic, does not cause drowsiness, dependence and, accordingly, withdrawal syndrome. It has a positive effect on cognitive functions, eliminates moderate pain in the heart, which are not related to angina pectoris. Unlike Afobazole, Adaptol is used in pediatrics. It is approved for children from 10 years of age.

Tenoten is used as a sedative and nootropic. It strengthens the central nervous system, improves memory and increases concentration, stimulates the body's resistance to stress. Tenoten, unlike Afobazole, is used to treat children from 3 years of age.

Novo-Passit is used as a muscle relaxant that has a hypnosedative effect. It is prescribed for the treatment of anxiety and psycho-emotional stress. Unlike Afobazole, Novo-Passit is a combination of extracts medicinal plants and guaifenesin. Novo-Passit can be used by children from 12 years of age. However, given the composition of Novo-Passit, adverse reactions in the form of an allergy in the drug are more pronounced than in Afobazole.

Another effective analogue of Afobazole is Grandaxin. It is indicated for fairly severe stress, increased and pronounced anxiety, deep depression and panic attacks. Grandaxin can be prescribed during pregnancy, excluding the first trimester. But for such effectiveness, you have to pay with a rather large list of side effects.

Persen is a herbal preparation with a directed sedative effect. He showed himself well in the treatment of insomnia and increased irritability. Persen normalizes the emotional state and sleep, but it is worth remembering that the plant base can cause a number of side effects (most often this is allergic reactions). But Persen does not eliminate the cause of the symptoms described above. Whereas Afobazol has a point action.

Phenibut and Afobazole are tranquilizers. Also, Phenibut is a nootropic. It has low toxicity and, unlike Afobazole, is used to treat children over 8 years of age in the prevention of motion sickness, the treatment of tics and stuttering.


Video: Afobazol drug: action, effectiveness, side effects, addiction

Afobazole is a sedative that is intended for long-term use. It is used for various nervous disorders, and you can buy it at a pharmacy without a prescription. Before starting a course of treatment, you should consult a specialist, because the human psyche is an extremely delicate mechanism.

Principle of operation and main properties

The medicine belongs to the group of anxiolytics, i.e. psychotropic drugs with a sedative and antipsychotic effect. It is used to reduce anxiety, improve sleep, reduce aggressiveness in mild forms of neurosis.

The principle of action of the drug is the effect on the receptors of γ-aminobutyric acid (GABA). This substance is an inhibitory mediator, and Afobazol enhances the susceptibility of receptors to it. Thus, the normal processes of inhibition are restored in the brain, which balance the excessive excitability.

The receptors affected by the drug are located in the areas of the cortex responsible for fine motor skills, memory and emotions. Due to the neuroprotective action and the normalization of inhibitory processes, Afobazole can also have a slight stimulating effect. It manifests itself with regular use - after a decrease in the level of anxiety, sleep normalizes, the patient feels rested, working capacity increases, and mood improves.

The drug is not addictive, but shows maximum effectiveness only with regular use.

The duration of the course should be clarified with the doctor. Effectively fights against suspiciousness, anxiety, mood instability, increased vulnerability and sleep disorders.

Description of the dosage form and composition

The main active ingredient of the drug is afobazole. It is an anxiolytic (tranquilizer), belonging to the group of non-benzodiazepine. The classification of anxiolytic drugs is based on the type of receptor they act on. For Afobazole, the main target is GABAergic receptors. The impact on them is milder, which gives fewer side effects than treatment with benzodiazepine drugs.

The drug is available in tablets intended for use during the course. In addition to the main substance, the tablet contains auxiliary components - potato starch, cellulose, magnesium stearate and other agents necessary for the tablet to be convenient to use and easily absorbed.

Instructions for use

The drug Afobazole is prescribed for the following disorders:

  • anxiety states, including neurosis and obsessive anxiety, as well as those caused by somatic diseases (CHD, dermatitis, etc.);
  • sleep disturbances caused by anxiety disorders;
  • cardiopsychoneurosis;
  • cyclic syndrome in women;
  • withdrawal syndrome;
  • various dependencies.

The drug can also be used for subjective feelings of increased anxiety, insomnia, suspiciousness and hypochondria. For those who decide to prescribe a medicine for themselves, it is especially important to follow the instructions.

Tablets are taken orally after meals. A single dose is 10 mg (this is 1 tablet of 10 mg or 2 tablets of 5 mg). You need to drink Afobazole three times a day at approximately equal intervals. Strict observance of intervals is not necessary, but desirable. The duration of the course of treatment is from 2 to 4 weeks (about 1 pack of tablets).

The doctor can change the regimen depending on the characteristics of the course of the disease in a particular patient. It is not recommended to extend the course for more than 4 months. If taking Afobazole does not bring relief, the patient should consult a doctor to select another drug.

Contraindications and side effects

Unlike most benzodiazepine anxiolytics, Afobazole has a fairly small number of side effects and contraindications. However, there are a number of situations in which drinking this drug it is forbidden. These include:

  • intolerance to the components of the drug;
  • intolerance to sugars - monosaccharides, galactose;
  • galactosemia;
  • children and adolescents (up to 18 years);
  • pregnancy and lactation.

The drug is prescribed with caution to patients with diabetes and other pathologies carbohydrate metabolism.

In kidney diseases, which are accompanied by a decrease in glomerular filtration, it is necessary to reduce the dosage.

Side effects are most often manifested in the form of allergic reactions - skin itching, rashes, rhinitis, vascular pathologies. Short-term digestive disorders are possible - abdominal pain, nausea and vomiting.

An overdose develops with a single dose of 40-50 mg or more. It is manifested by drowsiness, decreased motor activity, apathy, fatigue. Severe cases of poisoning are rarely recorded and are manifested by depression of consciousness, a significant decrease in muscle tone, and a drop in blood pressure. In such cases, injections of caffeine-sodium benzoate are prescribed, which are carried out in a hospital.

Which is better: Afobazol or ...

In pharmacies, you can find a lot of sedatives sold without a prescription, from plant extracts (valerian, motherwort, peony) to synthetic drugs to which Afobazol belongs. How to make a choice?

Tenoten

Tenoten contains purified antibodies to the S-100 protein produced in the brain. The medicine is homeopathic, nevertheless it is quite popular, although its effectiveness is largely debatable. Available in tablets.

It is prescribed for the same diseases as Afobazol, but does not have a sedative effect, only anti-anxiety. Unlike Afobazol, it is available in two dosage forms- for adults (from 18 years old) and for children (from 3 years old, children's Tenoten). It has the same list of contraindications as Afobazole - intolerance and carbohydrate metabolism disorders. Side effects when correct application do not develop.

With lungs anxiety disorders ah, there are no significant differences in effectiveness, they appear with relatively serious diseases, in this case Afobazol is more effective than Tenoten.

Persen is a combination of herbal extracts that comes in tablet form. The effect is sedative, anti-anxiety and antispasmodic. Because of the latter, Persen is more effective in vegetative-vascular dystonia, vascular tone disorders and migraines.

Unlike Afobazole, it has a longer list of contraindications - allergies to it are more common, it should not be taken by patients with diseases of the liver and kidneys, and used with caution in pathologies of carbohydrate metabolism.

Persen is acceptable for children over 12 years old, but unlike Afobazole, it cannot be used for arterial hypotension (Afobazole does not affect blood pressure).

Phenibut

The active substance of Phenibut is γ-amino-β-phenylbutyric acid, which is converted into GABA in the body. Unlike Afobazole, Phenibut increases the content of GABA in brain cells, but does not affect the sensitivity of receptors to it.

It has a wider range of applications than Afobazole: disorders of memory, thinking, emotional sphere, fine motor skills. With anxiety and insomnia, the use of Afobazole and Phenibut gives a comparable result. Phenibut is also used for pain syndromes caused by lesions of the spine - cervical, lumbar osteochondrosis.

Unlike all the drugs listed above, Phenibut does not contain lactose, so it can be taken in case of violations of the digestion and metabolism of carbohydrates. In addition, it is allowed for children from 8 years old. Unlike Afobazol, it requires more caution in diseases of the gastrointestinal tract.

Adaptol

Adaptol is a so-called daytime tranquilizer. Its action is not accompanied by muscle weakness and drowsiness; during the course of treatment, you can not interrupt work. In this case, the drug enhances the effect of drugs used to treat insomnia. This is due to the normalization of the emotional state of the patient.

Like Afobazole, it is used in the treatment of addictions and neuroses. More widely used to treat pain caused by nerve disorders. It has practically no contraindications, except for hypersensitivity. Unlike Afobazole, Adaptol can be used for violations of carbohydrate pressure. Designed for children from 10 years old.

Another representative of the group of daytime anxiolytics. It has the same range of applications as Afobazol. More effective for somatic pain caused by neurosis, premenstrual syndrome and postmenopausal pathologies.

Unlike Afobazole, Grandaxin cannot be used for depression and psychomotor agitation, aggressiveness.

It can be used during pregnancy (except for the 1st trimester), carefully - for violations of carbohydrate metabolism and kidney disease. It is dangerous to use in diseases of the respiratory system, with the syndrome of respiratory arrest during sleep, taking Grandaxin is prohibited.

Glycine

Glycine is an amino acid that has a neuroprotective effect and is one of the neurotransmitters. Glycine enhances the processes of inhibition in the nervous system, due to which its sedative effect is manifested. It is prescribed for stress, syndrome chronic fatigue, neurosis and treatment of withdrawal symptoms. It is acceptable for use in adolescents and children over 3 years of age. It is considered the safest of all drugs of this kind.

Atarax

It is used for the treatment of neurosis, anxiety disorders, skin itching, as well as for premedication (preparation for anesthesia). Hypersensitivity to this remedy, as well as related ones, often occurs, so its administration requires more careful consideration of contraindications. Not intended for children, pregnant or lactating women. The active substance is able to pass through the placental barrier.

Afobazole is quite safe and effective drug with neurosis and anxiety. It has a fairly wide range of analogues, so if there are contraindications, you can choose a replacement for it.

Prohibited during pregnancy

Prohibited while breastfeeding

Forbidden to children

Has restrictions for the elderly

Has limitations for liver problems

Has limitations for kidney problems

Constant stressful situations, anxiety states, chronic neuroses can lead to severe disorders not only of the nervous system, but also to violations of the functions of the whole organism. To combat stress, depression and neuroses, the use of benzodiazepine tranquilizers or antidepressants is justified.

The undoubted advantages of these funds include the speed of action. Although effective, the use of such medications can be addictive. Doctors recommend contacting such therapy only in emergency cases. Afobazol differs from other drugs in this group in that it, according to the instructions for use, is not addictive, and in that it can be used for long-term treatment.

Afobazole is an optimal replacement for antidepressants and tranquilizers. The absence of side effects during use, the effect of addiction and the withdrawal syndrome are among the hallmarks of the drug.

Significant advantages of Afobazole are its low level toxicity to the body and the possibility of using in complex therapy.

Also long-term use Afobazole is not accompanied by drowsiness, irritability, lethargy and deterioration in the standard of living of a person. The medicine is widely distributed among doctors and patients, and it can be purchased at a pharmacy without a prescription.

Drug group, INN, scope

Afobazole refers to selective non-benzodiazepine drugs with anxiolytic properties, derivatives of 2-mercaptobenzimidazole (does not apply to benzodiazepine receptor agonists). The INN of the drug is Afobazol.

The drug is widely used in psychiatry and neurology, in general somatic practice for manifestations of symptoms of depression, psychopathological disorders and in cases of pathological anxiety, which can occur in the form of seizures or be present all the time.

In cases of anxiety attacks, the patient complains of panic attacks, vegetative dysfunctions of the body, and the development of social phobia. At chronic form most often there are constant depressive and stressful conditions, as well as a violation of adaptation. For the treatment of these cases, if a long-term drug treatment, doctors use Afobazole.

Forms of release and prices for the drug, average in Russia

The medicine can be purchased in the form of beige or white round tablets. flat shape. They are produced in the amount of 10, 20, 25 pieces in plates and 30, 50, 60, 100 pieces in plastic jars. Most often sold in quantities of 60 pieces per bank. The country of origin of the drug is Russia. The average prices of Afobazole are presented in the table.

Composition and pharmacological properties

One tablet contains 5 mg or 10 mg fabomotizole dihydrochloride. Additional substances in the composition include:

  • potato starch - 48 mg;
  • lactose monohydrate - 48.5 mg;
  • medical medium molecular weight polyvinylpyrrolidone - 7 mg;
  • magnesium stearate - 1.5 mg.

Before starting therapy, it is important to understand how Afobazole works. The action of the drug is directed to the sigma-1 receptors of the nerve cells of the brain, due to which the stabilization of GABA receptors occurs.

The drug restores the structure of the GABA-benzodiazepine receptor complex due to sigma-1 receptors, which leads to the normal process of GABA binding to receptors. It also restores the high sensitivity of these receptors to inhibitory mediators. The drug has a protective and restorative effect on nerve cells, and also preserves their bioenergy reserve.

The action of Afobazole is represented by a combination of anxiolytic and weak stimulating action. Anxiolytic action is responsible for the elimination of anxiety. Thanks to these effects, the drug can significantly reduce the feeling of anxiety and the feelings of anxiety and fear, irritability, tension that precede it.

Patients feel relief from tearfulness, fear, insomnia, unreasonable fears, depressive mood and constant feeling of stress, dysfunctions of the digestive, cardiovascular, respiratory and musculoskeletal systems, sweating, and malaise.

After taking the drug, people note the restoration of concentration and memory, the complete absence of suspiciousness and the occurrence of disturbing thoughts, insecurity and apathy. Patients tend to have vivid emotional reactions to minor events.

The drug is well and quickly absorbed into digestive system. Substances are carried by the blood and quickly spread throughout the body. The drug is metabolized in the liver due to the processes of hydroxylation and oxidative reactions.

It is excreted from the body not only in the form of metabolites, but also in unchanged form with feces and urine. Excretion occurs quickly, which is associated with the breakdown into metabolic products in the liver immediately after entering the body. With prolonged use, the substances do not accumulate in the body.

When does it start to work?

The effectiveness of the drug can be seen after a week of taking the medicine. The maximum effect of the treatment is observed a month after the start of use and persists for several weeks after its completion. Taking Afobazole does not provoke the appearance of muscle weakness, drowsiness, decreased concentration and memory. At the end of treatment, no dependence or drug withdrawal syndrome is recorded.

Indications and contraindications

Afobazole is used as an anxiolytic agent in cases of anxiety. It is important to know exactly what the remedy helps with. These are, in particular, the states that manifest themselves:


Also indications for use include:

  • attacks of anxiety and neurasthenia;
  • bronchial asthma;
  • lupus;
  • hypertension;
  • arrhythmia;
  • dermatological diseases;
  • oncological diseases;
  • acute premenstrual syndrome;
  • panic attacks;
  • withdrawal syndrome of long-term use of alcohol or smoking;
  • insomnia.

It is contraindicated to take the medicine to persons with hypersensitivity to the components, people with lactase and galactose intolerance (as they are present in the composition), for children under 18 years of age and during pregnancy, because it crosses the placenta and may adversely affect the development of the fetus.

With hepatitis B, it is also not recommended to take the medicine, however, in cases where treatment is necessary, breast-feeding stop before the end of taking Afobazole, (which is associated with the possibility of penetration of substances into breast milk).

It is also forbidden to take the drug to people with:

  • brain diseases or injuries;
  • diseases and dysfunctions of the peripheral and central nervous system;
  • inhibition of the functionality of the CNS.

The drug does not affect the ability to drive vehicles and perform work that requires increased concentration.

Instructions for use

According to the instructions for use, Afobazole is taken orally after a meal, washed down with water. The dosage depends on the nature of the underlying pathology.

Dosage course duration for adults?

For adults minimum single doses in tablets - 10 mg, and daily - 30 mg. The dose is recommended to be divided into 3 doses during the day. The effectiveness of taking the drug can be seen after a few weeks, and the maximum effect appears after a month. In some cases, the doctor may increase daily dose up to 60 mg, and extend the treatment up to several months.

In the case of taking Afobazole, it is important when it is taken - before meals or after, since the safety of therapy depends on this. The best option is to take half an hour after eating.

With VSD and panic attacks

With VVD and panic attacks, it is very important to follow the rules for taking the medication. It must be remembered that the use of Afobazole for a one-time relief of an attack is not effective. In order to see the result and eliminate the appearance of attacks, you must take the drug regularly. In severe forms of panic, drink 6 tablets 3 times a day. When mild form disorders, doctors recommend taking 3 tablets 3 times a day.

Treatment for panic attacks can last from several weeks to several months, which depends entirely on the severity of the attacks. The result from taking Afobazol lasts for several weeks after the pills are discontinued. With the return of panic attacks and the manifestation of symptoms of VVD, the doctor may prescribe re-treatment. In some cases, 6 tablets of Afobazole can cause side effects, therefore the dose is individually adjusted by the doctor for each patient.

Afobazole does not treat the causes of attacks, but only eliminates the manifestation and consequences of attacks.

In order to completely get rid of seizures, it is necessary to undergo a course of treatment with a psychotherapist, since such attacks are the result of mental trauma received in childhood, hidden fears, severe stress and emotional upheavals, depression or manifestations of VVD.

Especially dangerous are cases when panic is caused by prolapse mitral valve, hypothyroidism, hypoglycemia, or a CNS disorder that only a doctor can diagnose. Therefore, treatment with this medicine is recommended to be carried out under the supervision of a specialist.

With menopause

Afobazole is also popular in gynecology. This medicine is prescribed to patients with vivid symptoms of menopause, namely:

  • sharp fluctuations in body temperature;
  • feeling of weakness and malaise, decreased performance;
  • increased emotionality;
  • sweating;
  • sleep problems, insomnia;
  • lack of sexual desire.

In such cases, the drug is recommended to be taken three times a day, 1 tablet. The duration of treatment is determined by the gynecologist himself. In cases where these symptoms are accompanied by prolonged depression and stressful conditions, doctors recommend Afobazole in combination with sedatives.

Possible side effects and overdose of Afobazole

The drug causes side effects very rarely. The most common include itching, rash, redness of the skin, which is provoked by hypersensitivity to the composition of the drug. Also, sometimes dyspeptic processes can occur, which are manifested by nausea, vomiting, abdominal pain, constipation, diarrhea or diarrhea. These symptoms disappear immediately after stopping the pills.

An overdose of the drug is manifested when taking a large number of tablets. This amount is considered a single dose of more than 6 tablets.

An overdose of the drug can be detected due to the appearance of such symptoms:

  • the appearance of sharp headaches resembling migraine;
  • drowsiness, weakness, malaise;
  • difficult, slurred speech;
  • delayed reaction;
  • weak or heavy breathing;
  • a sharp increase in the heartbeat and its sharp weakening;
  • the appearance of seizures;
  • apathy.

These symptoms are provoked by CNS depression under the action of a large amount of the active substance. If at least a few symptoms of an overdose are detected, it is necessary to provide the victim with first aid.

First of all, it is necessary to give a person a lot of water to drink and press on the root of the tongue, causing a gag reflex. This will help remove substances from the body that have not yet had time to assimilate in the digestive system. After that, a person is given an adsorbent, such as activated charcoal, in order to remove all toxins. In cases of overdose, doctors advise giving the victim strong coffee to drink, since caffeine reduces the effect of Afobazole on the nervous system.

In the following hours, it is necessary to solder a person with plenty of water, which will help to remove the remaining substances in the body. After the condition improves, it is necessary to take the victim to the doctor for examination. In cases of severe intoxication of the body with an overdose of the victim, they are treated in a hospital under the supervision of doctors until the functions of the body are fully restored.

Compatibility of Afobazole with drugs and alcohol

Afobazole enhances the action, which eliminates convulsions, and which helps to cope with frequent anxieties. Does not affect the action.

With Glycine

Glycine is food supplement, which is a non-essential amino acid. It has a positive effect on the central nervous system, improves concentration, especially in the educational process, and also improves the cognitive properties of the body. Has no harmful effect on the body. Glycine is used as a nootropic drug that has sedative and sedative properties. It can be used not only for treatment, but also for complex therapy and prevention.

It is recommended to drink not only the sick, but also healthy people for prevention purposes. Glycine is prescribed to improve the quality of sleep and the stability of a person's emotional state. This is achieved due to the effect of Glycine on the launch of GABA, that is, an inhibitory neurotransmitter. The drug is also widely used to treat different forms VVD, as it has antioxidant and alpha-adrenergic blocking properties.

Afobazole, in turn, is used for more serious manifestations of nervous disorders and VVD. These drugs can be used simultaneously, as they do not affect the effectiveness and actions of each other.

With alcoholic drinks

According to the manufacturer, alcohol does not affect the effect of the drug. Despite this, doctors do not recommend taking medication and alcohol together. With a one-time parallel intake of medication and alcohol, there will be no significant negative effects.

In such cases, the drug may simply not show its effect, which is due to the fact that alcohol has a sedative and relaxing effect due to the inhibition of the central nervous system. Afobazole gradually stimulates the nervous system, thus helping the patient cope with stress or anxiety.

With prolonged simultaneous use, unwanted and unpredictable side effects may occur. Also, the drug may lose its effectiveness due to the negative effect of alcohol on metabolism. In such cases, a person may start taking large amounts of pills himself, and a large amount of the active substance and alcohol intoxication can cause death.

Doctors categorically forbid treatment with medicine in cases of alcohol intoxication. The optimal time that should elapse between taking alcohol and starting treatment is a few days.

This period is individual for each person and depends on the amount of alcohol consumed. It should be remembered that in the case of the interaction of alcohol and the active substance, the patient's condition may deteriorate significantly, and unexpected consequences may occur, primarily associated with an increase in the disease.

Taking a drug to relieve the symptoms of a hangover is pointless, since by the time Afobazole begins to act, the body will already get rid of alcohol intoxication. It has a positive effect only in cases of treatment of the consequences of prolonged alcohol intake.

Features of therapy for stress and anxiety disorders

Afobazole helps to cope with the symptoms of stress and anxiety. Despite this, it does not affect the causes of these conditions. At the end of the medication, seizures may reappear. To eliminate the causes of stress and anxiety, you need to contact narrow specialists.

To determine the effectiveness of the drug, studies were conducted on the basis of Moscow and St. Petersburg research psychoneurological institutes. It has been proven that Afobazol is similar in its action to Diazepam. The drug differs from Diazepam in its high tolerability, lack of muscle relaxant action and inhibition of cognitive functions. This was the reason for further research.

Scientists considered the main goal to establish the effectiveness of the drug in cases of anxiety. To do this, a naturalistic study was conducted, which involved people from 18 to 65 years old with nervous disorders, depression and anxiety. The exceptions were cases of schizophrenia, epilepsy, frequent panic attacks, somatic diseases in the acute stage.

The subjects took the drug three times a day, 15-20 mg for a month and a half. Various evaluation methods have been used to better determine effectiveness. Each patient had his own card with notes about the condition, which was checked every 7 days.

194 patients were studied, 45 men, 149 women. Since disorders of the nervous system are more characteristic of women, they were the majority. The experiment involved people with disorders lasting from several months to several years. For treatment, patients have previously used antidepressants or tranquilizers.

In the first week of the study, the level of anxiety of patients decreased by 22%. In the 3rd week, the indicators rose to 50%. By the 6th week, the indicator reached 73%. Analysis of the results showed the presence of a constant and harmonious decrease in the severity of anxiety. Starting from the first week, patients complained less about their well-being.

Earlier studies have shown that side effects manifest themselves to a greater extent in the first week.

These effects were represented by increased anxiety, drowsiness and sleep disturbance. Their most acute manifestation was the exacerbation of somatic disease. In general, side effects were very rare. The results showed that the effect of Afobazol does not depend on age or gender. It has also been shown that the drug reaches its maximum effect at the 3rd week after the start of treatment. At the end, it was found that the stimulating effect prevailed over the sedative.

The main disadvantage of this study is its lack of objectivity. This is due to the fact that not all patients could soberly evaluate the results of the drug. A positive effect could arise solely due to self-hypnosis of people.

To avoid such situations, the double placebo method is used, when half of the patients are given a placebo pill, and the other half are given the real drug. Patients do not know which pills they are being treated with and are unaware of important details of the study. It is this method that helps to determine that the effect of the drug is based on its properties, and not on the self-hypnosis of patients. Data on the conduct of such research methods for Afobazole was not found.

Studies have confirmed high efficiency drug in the treatment of neurotic disorders. Also, the drug is well tolerated and easy to use.

Such a drug falls into the group of tranquilizers, but at the same time it has a very mild effect on the human body. It does not cause addiction in the patient and does not provoke the development of a withdrawal syndrome at the end of therapy. In order to receive only pluses from taking the remedy, you must strictly follow the instructions for the use of Afobazol.

To date, the only form of release of "Afobazol" is tablets. They are white/cream colored. There are two dosage options for the main active ingredient in pills - 5 and 10 mg. Tablets are packaged in blisters or glass jars (from 10 to 100 pieces, depending on the packaging option).

The main active component of the drug was fabomotizol. The product also includes auxiliary ingredients: starch (potato), lactose monohydrate and some others. The composition was the same for both dosage options.

Pharmacological properties and indications for use

The main active ingredient of the drug reduces a person's feeling of anxiety, calms, eliminates irritability and even has a positive effect on mood. At the same time, unlike most analogues, the drug does not cause memory loss, does not reduce brain activity and concentration, does not lead to the development of drowsiness and other similar effects. In addition, it does not form drug dependence.

In addition to eliminating anxiety, the drug has the following effects on the patient's body:

  • struggles with bad feelings, feelings of concern, fear, etc.;
  • improves night sleep (without morning and daytime sleepiness);
  • relieves psycho-emotional stress;
  • helps relax.

The medicine leads to a decrease in spasm of the muscles of the genital organs, reduces sweating, relieves dizziness and dry mouth.

It is especially important to use such a remedy for anxious, suspicious people with increased emotionality.

Soon after taking the drug, the main active substance is completely absorbed into the blood and quickly spreads throughout the body. Excreted by the kidneys.

Specialists prescribe pills for the following problems:

  • sleep disturbance caused by anxiety;
  • disorder of social adaptation of a person;
  • severe premenstrual syndrome;
  • "breaking" in the fight against alcoholism and smoking;
  • cardiopsychoneurosis.

Often discussed medicinal product used as part of the complex therapy of various serious illnesses. For example, with asthma (bronchial), some problems with the heart and blood vessels (when oxygen and nutrients enter the heart muscle in an amount insufficient for its normal functioning), increased blood pressure and some others. The medicine helps to cope with tearfulness, capriciousness, depression, which are typical for patients suffering from various heart diseases.

Pills are also prescribed for ailments that cause a person to feel inferior and doubt the ability to be in society.

Instructions for use "Afobazole"

It is very important to know exactly how to take Afobazol according to a scheme that is safe for the patient's body. Such tablets, unlike other tranquilizers, are allowed to be consumed immediately in a full portion, and not to increase the dosage slowly and gradually. This is due to the mild effect of the drug. It doesn't take time to get used to it. It is allowed to use the drug once, because it does not cause addiction in patients.

It must be remembered that after the completion of taking the remedy, its effect will persist for another 10 to 15 days. During this period, other drugs with a similar effect should be abandoned.

The drug is suitable only for adult patients. The tablet should be taken shortly after a meal. It is consumed whole (without chewing and other damage). The medicine is washed down with water without sugar and gas. A small amount of liquid is enough.

  • If this is the 10 mg option, then 1 pill is consumed three times a day.
  • If 5 mg, then 2 tablets in the same number of doses.

It is desirable to observe approximately equal intervals between pills.

The standard course of therapy with this drug is 14 - 28 days. After the maximum period has elapsed, the reception must be stopped for a while. You can repeat the course not earlier than in another month.

It is allowed to increase the duration of treatment and dosage only under the strict supervision of an experienced specialist.

Can I take during pregnancy and lactation

The medicine in question is a tranquilizer. It is strictly forbidden to take it during pregnancy, regardless of its duration. It is better for a woman to cope with anxiety during the period of bearing a baby with the help of folk remedies and special herbal medicines.

The drug is also prohibited during lactation. If a young mother decides to start taking the drug, she will have to transfer the baby to artificial feeding.

Compatibility "Afobazole" and alcohol

The main active component of the drug under discussion does not react with ethyl alcohol. But this does not mean at all that Afobazole and alcohol can be safely drunk together.

Such information from the instructions for the remedy only suggests that the drug can be taken, for example, with a hangover. It helps to cope with the unpleasant symptoms that accompany this condition.

"Afobazole" stimulates the nervous system, slows down the process of absorption of alcohol that has already entered the stomach, accelerates the process of excretion of substances formed during the breakdown of alcohol from the body. At the same time, the drug is not suitable for the treatment of alcohol dependence at any stage. It can only stop the main symptoms of a hangover and improve the general condition of the patient at the same time. For this purpose, it is taken no more than 2 times a day for 10-20 mg.

It must be remembered that alcohol neutralizes the healing effect of the drug on many systems and organs. For example, if the remedy is used by women to improve their condition during menopause.

Just one serving alcoholic drink significantly reduce the effectiveness of "Afobazole" and lead to the fact that all the unpleasant symptoms of the problem return.

It is especially dangerous to combine the drug and alcohol in case of problems with the heart and blood vessels, lungs, bronchi. Such a “neighborhood” can also strengthen the neurotic states of the patient.

Drug interactions with other drugs

As noted above, the components of the drug do not interact with ethyl alcohol. Therefore, it can be combined with certain alcohol-based medications.

Using the tool in parallel with "Diazepam" and "Carbamazepine", you need to remember that it enhances their effect.

Contraindications, side effects and overdose

The drug under discussion also has a whole list of contraindications. It must be carefully studied before starting the reception.

The medicine is strictly prohibited with the following features of the patient's body:

  • hypersensitivity, intolerance to individual components of the drug or allergic reactions to them;
  • lactase deficiency;
  • childhood.

If the patient is taking any medications (including to alleviate the symptoms of chronic ailments), he should be sure to inform the doctor who recommends taking Afobazole. This may cause changes in the regimen for taking new pills or even a delay in starting therapy.

Cases of drug overdose are rare, since the correct treatment regimen for such tablets is simple and straightforward. Usually the problem appears with the erroneous simultaneous use of pills in large quantities. If for a long time the patient slightly overestimates the dosage of the drug, then an overdose will not develop, because its components do not accumulate in the tissues of the body.

When a problem occurs, a person will notice the following symptoms:

  • drowsiness without weakness in the muscles (it can occur even immediately after getting out of bed in the morning);
  • excessive calmness and even “inhibition”.

To cope with an overdose will allow a solution of caffeine sodium benzoate (20 percent). The drug is administered by injection 2 to 3 times a day, and always subcutaneously.

Patients treated with Afobazol, in rare cases, may experience side effects of the drug. First of all, among them it is necessary to single out migraine and all kinds of allergic reactions (most often manifested in the form of a skin rash). Such manifestations do not require special treatment. There is no need to cancel the drug.

It happens that patients notice an increase in their sexual desire soon after the start of therapy with the discussed tablets. This is not a side effect of the drug, but a consequence of the removal of anxiety and nervous tension.

Analogues

In modern pharmacies, a large number of analogues of "Afobazol" are presented. Among the cheapest can be noted the Belarusian "Fenibut". It is also prohibited for pregnant women.

Other analogues of "Afobazole": "Mebikar" (produced in Russia), "Anvifen", "Atarax", "Tenoten", "Persen". Novo-Passit is also particularly popular among buyers.

Afobazole is an anxiolytic (anxiety-reducing) drug that appeared in domestic pharmacies in the early 2000s. The drug is intended mainly for sedative purposes. Active Ingredients medicinal product is afobazole.

Pharmacological action of Afobazole

According to the instructions, Afobazol reduces anxiety and calms. The use of the drug does not cause either psychological or physical dependence in the patient, even with prolonged use. Also, reviews of Afobazol confirm that the remedy does not negatively affect concentration and memory, does not reduce muscle tone, so it can be used at any time of the day and under any circumstances. When taking the drug, there is no withdrawal syndrome, in other words, if the treatment is abruptly stopped, the patient's condition will not worsen in any way.

From the instructions for Afobazole, you can find out that the drug produces a double effect - it relieves feelings of anxiety and has a slight stimulating effect. The elimination of nervous tension and anxiety has a beneficial effect on the psychological and physical condition of the patient. The action of the drug, which is aimed at reducing feelings of anxiety, allows you to stop the symptoms of muscle, cardiovascular, respiratory and gastrointestinal failures present in somatic disorders. Many reviews of Afobazole do not deny that the drug reduces the frequency of autonomic disorders: dry mouth, sweating and dizziness.

The use of Afobazole helps to increase concentration and improve memory.

Positive changes in the body are already observed on the 5th-7th day of taking the drug. The maximum effect can be felt after 3-4 weeks of treatment, and it lasts for 1-2 weeks. But this figure depends on the metabolic rate of each patient individually. Reviews about Afobazole also indicate that the drug is excellent for people who suffer from increased vulnerability, emotional instability, suspiciousness, and self-doubt.

The drug is non-toxic, which is confirmed by studies conducted on animals.

According to the instructions, Afobazole is absorbed in the gastrointestinal tract very well, has a high degree binding to plasma proteins. The drug is quickly excreted from the body.

Indications for the use of Afobazole

Afobazole is prescribed for:

  • anxiety conditions such as adjustment disorders, neurasthenia, general anxiety disorders;
  • oncological and dermatological diseases (according to the doctor's indications);
  • somatic diseases such as bronchial asthma, irritable bowel syndrome, hypertension, systemic lupus erythematosus, ischemia, arrhythmia;
  • sleep disorders;
  • premenstrual syndrome;
  • neurocirculatory dystonia;
  • alcohol withdrawal syndrome;
  • giving up cigarettes to alleviate the condition.

Method of application of Afobazole and dosage

Dosages are selected individually depending on the type and severity of the disease, as well as general condition patient.

As a rule, the dose of Afobazole at the initial stage of treatment is 10 mg per dose, the daily dose is 30 mg. If necessary, the dosage is increased to 60 mg during the day. The duration of treatment is on average 2-4 weeks, but in some cases the doctor extends it to 3 months or prescribes a second course after a while.

Side effects of Afobazole

Taking Afobazole sometimes leads to side effects such as:

  • work disorders gastrointestinal tract: vomiting, diarrhea, nausea;
  • allergic reactions: rash, redness, urticaria, itching on the skin.

Contraindications to the use of Afobazole

The remedy is also contraindicated for lactose intolerance - hypolactasia.

Afobazole and alcohol

When treating with Afobazol, alcohol is not strictly prohibited, since the drug does not enhance the narcotic effect of drinks and does not provoke poisoning. However, it is not recommended to combine the drug with drinks containing alcohol, since the effectiveness of treatment is reduced to almost zero.

Also, the use of alcohol and Afobazole by women in the treatment of hormonal disruptions does not lead to positive results.

Afobazole storage conditions

The drug should be stored in a dark, dry place at an air temperature not exceeding 25 degrees. Shelf life is 2 years, after which the product can not be used.